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1. Hospital Pharmacy and Research

Author

Christian Surber, Carolina Pellanda, Katja Zimmermann, Manuela Endres, Verena Figueiredo, Roland Werner, Herbert Plagge, and Ruth Leu Marseiler

Subjects
Clinical pharmacy, Cutaneous administration, Hospital pharmacy, Intranasal administration, Topical bioavailability, Chemistry, QD1-999
Abstract

Hospital pharmacies play a crucial role in managing and/or accompanying the entire drug handling process, from the drug's origin all the way through the hospital system to the patient, and to promote rational and appropriate drug use. Drug preparation – still part of this process – has not disappeared from the fields of activity of hospital pharmacists. However, this activity is bound to many legal constraints and, therefore, remains reserved to a limited circle of hospitals that can offer such services. Based on a national license (Swissmedic), the Institute of Hospital Pharmacy of the University Hospital of Basel offers opportunities to provide drug preparations according to current guidelines. These preparations include patient-individualized drug preparations (compounding) to fulfil special needs in oncology, dermatology, paediatrics and other disciplines. Additionally this national license enables our institution to prepare drug preparations for clinical research. This is the basis of an important activity of our institute: to prepare clinical research samples for the pharmaceutical industry and for clinicians at the university hospital, to support industry independent research, and to conduct our own research in biopharmaceutics in collaboration with other national and international institutions. Against this background we report on our research support activities, and, in more detail, on our own research and development programs in biopharmaceutics: dermal and intranasal bioavailability.

Published
2006
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2. Topical Bioavailability of Triamcinolone Acetonide: Effect of Occlusion

Author

Christian Surber, T. Rufli, V. Figueiredo, Georgios Imanidis, Carolina Pellanda, and C. Strub

Subjects
Adult, Male, Triamcinolone acetonide, Physiology, Administration, Topical, Skin Absorption, Biological Availability, Dermatology, Pharmacology, Triamcinolone Acetonide, Skin hydration, Occlusion, medicine, Humans, integumentary system, Chemistry, food and beverages, General Medicine, Bandages, Topical bioavailability, Anesthesia, Drug reservoir, Female, Biological availability, medicine.drug
Abstract

Background/Aims: Occlusion by covering the skin with an impermeable wrap enhances skin hydration, affects drug absorption and can induce the formation of a drug reservoir within the stratum corneum. This is desired in local therapy with topical corticosteroids. The aim of the study was to investigate the effect of occlusion before (experiment 1) and after (experiment 2) application on the penetration of triamcinolone acetonide (TACA) into the stratum corneum. Methods: The experiments were conducted on the forearms of 10 healthy volunteers. In experiment 1, 100 µg/cm2 TACA in acetone were applied on 3 sites per arm, one arm having been pre-occluded for 16 h. In experiment 2, the same dose was applied on 2 sites per arm, and one arm was occluded after application until skin sampling. Stratum corneum samples were removed by tape stripping at 0.5, 4 and 24 h (experiment 1) and 4 and 24 h (experiment 2) after application. Corneocytes and TACA were quantified by ultraviolet-visible spectroscopy and HPLC, respectively. The total TACA amount penetrated into the stratum corneum was evaluated by multifactor ANOVA. Results: TACA penetration into the stratum corneum with and without pre-occlusion (experiment 1) showed no significant difference and decreased with time. Occlusion after application (experiment 2) produced a marked TACA accumulation within the stratum corneum, which persisted for 24 h. Conclusion: Pre-occlusion showed no effect on the topical bioavailability of TACA in the stratum corneum. In contrast, post-occlusion enhanced the TACA penetration by a factor of 2, favouring the development of a drug reservoir.

Published
2006
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3. Topical bioavailability of triamcinolone acetonide: effect of dose and application frequency

Author

Georgios Imanidis, Christian Surber, Theo Rufli, Evelyne Ottiker, Christoph Strub, Verena Figueiredo, and Carolina Pellanda

Subjects
Adult, Male, Triamcinolone acetonide, Chromatography, medicine.drug_class, Stereochemistry, Chemistry, Administration, Topical, Multiple applications, Dermatology, General Medicine, Triamcinolone Acetonide, High-performance liquid chromatography, Topical bioavailability, Bioavailability, Pharmacokinetics, In vivo, Adhesives, medicine, Humans, Corticosteroid, Female, Epidermis, Glucocorticoids, medicine.drug
Abstract

The application frequency of topical corticosteroids is a recurrently debated topic. Multiple-daily applications are common, although a superior efficacy compared to once-daily application is not unequivocally proven. Only few pharmacokinetic studies investigating application frequency exist. The aim of the study was to investigate the effect of dose (Experiment 1) and application frequency (Experiment 2) on the penetration of triamcinolone acetonide (TACA) into human stratum corneum (SC) in vivo. The experiments were conducted on the forearms of 15 healthy volunteers. In Experiment 1, single TACA doses (300 microg/cm(2) and 100 microg/cm(2)) dissolved in acetone were applied on three sites per arm. In experiment 2, single (1 x 300 microg/cm(2)) and multiple (3 x 100 microg/cm(2)) TACA doses were similarly applied. SC samples were harvested by tape stripping after 0.5, 4 and 24 h (Experiment 1) and after 4, 8 and 24 h (Experiment 2). Corneocytes and TACA were quantified by UV/VIS spectroscopy and HPLC, respectively. TACA amounts penetrated into SC were statistically evaluated by a paired-sample t-test. In Experiment 1, TACA amounts within SC after application of 1 x 300 microg/cm(2) compared to 1 x 100 microg/cm(2) were only significantly different directly after application and similar at 4 and 24 h. In Experiment 2, multiple applications of 3 x 100 microg/cm(2) yielded higher TACA amounts compared to a single application of 1 x 300 microg/cm(2) at 4 and 8 h. At 24 h, no difference was observed. In conclusion, using this simple vehicle, considerable TACA amounts were retained within SC independently of dose and application frequency. A low TACA dose applied once should be preferred to a high dose, which may promote higher systemic exposure.

Published
2006
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4. Low-Dose Triamcinolone Acetonide in the Phytocosmetic Lichtena® Reduces Inflammation in Mild to Moderate Atopic Dermatitis

Author

Andreas J. Bircher, Carolina Pellanda, Christian Surber, and M. Monika Weber

Subjects
Allergy, Chemotherapy, medicine.medical_specialty, Triamcinolone acetonide, medicine.drug_class, business.industry, medicine.medical_treatment, Dermatology, Atopic dermatitis, medicine.disease, law.invention, body regions, Atopy, law, Immunopathology, medicine, Corticosteroid, Phytotherapy, business, medicine.drug
Abstract

Background: Previously, we reported the efficacy of Lichtena® – a phytocosmetic cream product – in atopic dermatitis (AD). Later, fraudulent triamcinolone acetonide (TACA) was detected at low doses (16–40 µg/g) in Lichtena. This suggested that TACA may be effective at much lower concentrations than used in commercial products (1,000 µg/g). Objectives: To investigate the efficacy in AD of low-dose TACA in Lichtena compared to plain Lichtena. Methods: Fourteen patients presenting symmetrical lesions of AD were treated for 1 month with Lichtena plus 25 µg/g TACA (= verum) and plain Lichtena (= placebo). The severity of the lesions was assessed by the Severity Scoring of Atopic Dermatitis (SCORAD) on days 0 (= baseline), 7, 14 and 28. Results: Already after 1 week of treatment, significant SCORAD differences to baseline were observed comparing verum- and placebo-treated areas. No improvement was observed using plain Lichtena. Conclusions: TACA displayed a significant improvement of AD at doses up to 40 times lower than in commercial products.

Published
2005
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5. Contents Vol. 211, 2005

Author

Christos C. Zouboulis, M. Monika Weber, Selim Aractingi, Venkata Putcha, Isabelle Daigle, M.A. Duchosal, J.L. Arranz López, Hiroyuki Matsue, E. Gambillara, Jann Lübbe, D.A. Fairhurst, P. Dellamonica, Christian Surber, Dominique Bonneau, Emmanuel Laffitte, Olivier Sorg, Katrin Kerl, Dan Lipsker, Karin Thoss, Wolfram Sterry, Henrik Møller, Maria Morales, E. Counillon, Alice Quinart, P. Del Giudice, Andreas J. Bircher, Mohammad Reza Fallahi, Agustin Llopis, Uwe Trefzer, Alexander C. Katoulis, Jean-Hilaire Saurat, Nicholas G. Stavrianeas, Jørn Olsen, Marc Buffet, Pierre Carraux, Thomas J. Brill, N. Kunzle, Mohammad Nikbakhsh, Hans-Peter Baum, J.-H. Saurat, Ambros Hügin, M. Grelier, Paulette Bioulac-Sage, Naohito Hatta, Farshad Farnaghi, Lutz Kowalzick, Philippe Revel, Carol M. Artlett, Gholamhosein R. Omrani, T. Rodriguez Bravo, Sébastien Lepreux, Katharina Spanaus Schlapbach, Carolina Pellanda, Günter Burg, Günther F.L. Hofbauer, Christine Labreze, N. Widmer, H. Zeller, Jürgen Quietzsch, Hassan Seirafi, A. Carlotti, I. Schuffenecker, Sylvie De Maricourt, Luca Borradori, Rahman Nazari, Sofia Georgala, Roland Blum, Laurence Doelker, Christian Tran, Emmanuel Molinari, Christophe Antille, Jürgen Lademann, Akiko Nagasaka, I. Masouyé, P. Lesavre, Mitra Amini, J.-M. Pönnighaus, Renato G. Panizzon, Amin Parhizgar, L.A. Decosterd, H. Zachariae, Daniel Mischke, S.M. Clark, Julie De Quatrebarbes, E. Laffitte, Ute Jacobi, Evelyne Leemans, Giovanni Luigi Capella, Diamant Thaçi, Nicolas Dupin, Hans-Uwe Simon, Reinhard Dummer, Eva M. Valesky, Julien Gautier, Denise Grand, Behrooz Kasraee, Jörg Willers, Thierry André, F. Vandenbos, T. Kovacsovics, Parisa Mansoori, Aiko Miyahara, Heidrun Ziegler, L. Garcia Martinez, Gürkan Kaya, Shinji Shimada, Julien Autier, J.-P. Venetz, Farhad Handjani, M. Pascual, Roland Kaufmann, Thomas Elshorst-Schmidt, Arash Taheri, Regina Treudler, Martine Neau-Cransac, Pierre Vabres, E. Elena Sorando, Maryam Akhyani, Jean Saric, Helen S. Evans, Isabelle Gorin, and Silvio Hemmi

Subjects
Dermatology
Published
2005
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6. CONCOMITANT TREATMENT WITH ALEGLITAZAR DOES NOT CHANGE THE EFFECTS ON RENAL FUNCTION INDUCED BY ASPIRIN

Author

F. Hoffmann-La Roche Ag, Dennis Ruff, Carolina Pellanda, Ruth Penn, Annette Sauter, Zainab Ansari, and Thorsten Ruf

Subjects
Agonist, Acute coronary syndrome, medicine.medical_specialty, Aspirin, Aleglitazar, medicine.drug_class, business.industry, Renal function, Type 2 Diabetes Mellitus, medicine.disease, chemistry.chemical_compound, chemistry, Concomitant, Internal medicine, medicine, Cardiology, Receptor, business, Cardiology and Cardiovascular Medicine, medicine.drug
Abstract

Aleglitazar is a dual peroxisome proliferator-activated receptor a/? agonist in development for cardiovascular risk reduction in patients following an acute coronary syndrome (ACS) who have type 2 diabetes mellitus. Most ACS patients receive aspirin, which is associated with decreased glomerular

Published
2012
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8. Subject Index Vol. 211, 2005

Author

P. Del Giudice, Ambros Hügin, Marc Buffet, Regina Treudler, T. Rodriguez Bravo, Arash Taheri, Carolina Pellanda, Thomas J. Brill, Martine Neau-Cransac, Andreas J. Bircher, Emmanuel Molinari, Jørn Olsen, E. Gambillara, Olivier Sorg, J.-M. Pönnighaus, Christophe Antille, Paulette Bioulac-Sage, Denise Grand, Thierry André, Alexander C. Katoulis, I. Masouyé, M.A. Duchosal, Julie De Quatrebarbes, H. Zachariae, Henrik Møller, Alice Quinart, S.M. Clark, Amin Parhizgar, Giovanni Luigi Capella, Hans-Uwe Simon, Carol M. Artlett, M. Grelier, Julien Gautier, Selim Aractingi, Gürkan Kaya, Sébastien Lepreux, Julien Autier, Pierre Vabres, Mohammad Reza Fallahi, Jean-Hilaire Saurat, J.-P. Venetz, I. Schuffenecker, M. Monika Weber, Daniel Mischke, Maryam Akhyani, Günther F.L. Hofbauer, Venkata Putcha, Pierre Carraux, Farhad Handjani, Akiko Nagasaka, E. Counillon, Diamant Thaçi, Jann Lübbe, Farshad Farnaghi, Lutz Kowalzick, M. Pascual, Christian Surber, Dominique Bonneau, Dan Lipsker, Emmanuel Laffitte, Katrin Kerl, T. Kovacsovics, Roland Kaufmann, Thomas Elshorst-Schmidt, Agustin Llopis, Hassan Seirafi, Jörg Willers, Luca Borradori, Parisa Mansoori, Shinji Shimada, Heidrun Ziegler, L.A. Decosterd, N. Kunzle, Rahman Nazari, Sofia Georgala, Christine Labreze, F. Vandenbos, Jürgen Lademann, Nicolas Dupin, Behrooz Kasraee, Christos C. Zouboulis, Isabelle Daigle, P. Lesavre, Mitra Amini, Hiroyuki Matsue, Uwe Trefzer, Philippe Revel, Nicholas G. Stavrianeas, J.L. Arranz López, Karin Thoss, Jürgen Quietzsch, Sylvie De Maricourt, D.A. Fairhurst, P. Dellamonica, Renato G. Panizzon, Hans-Peter Baum, Reinhard Dummer, Ute Jacobi, Evelyne Leemans, Helen S. Evans, Maria Morales, Eva M. Valesky, Isabelle Gorin, Katharina Spanaus Schlapbach, N. Widmer, Laurence Doelker, Christian Tran, Wolfram Sterry, Aiko Miyahara, L. Garcia Martinez, Roland Blum, Silvio Hemmi, E. Elena Sorando, Jean Saric, H. Zeller, E. Laffitte, Gholamhosein R. Omrani, Mohammad Nikbakhsh, A. Carlotti, J.-H. Saurat, Naohito Hatta, and Günter Burg

Subjects
Index (economics), Statistics, Subject (documents), Dermatology, Mathematics
Published
2005
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9. Acknowledgement to Referees for Dermatology 2005

Author

M. Grelier, Denise Grand, Thierry André, Paulette Bioulac-Sage, Henrik Møller, Thomas J. Brill, Regina Treudler, Pierre Carraux, Sébastien Lepreux, Carol M. Artlett, Christophe Antille, I. Masouyé, Silvio Hemmi, Amin Parhizgar, Alice Quinart, Gholamhosein R. Omrani, S.M. Clark, D.A. Fairhurst, P. Del Giudice, Ambros Hügin, E. Elena Sorando, A. Carlotti, Nicholas G. Stavrianeas, Martine Neau-Cransac, P. Dellamonica, Jean Saric, Farshad Farnaghi, I. Schuffenecker, Emmanuel Laffitte, Katrin Kerl, Lutz Kowalzick, Marc Buffet, Selim Aractingi, M. Monika Weber, Julien Autier, L.A. Decosterd, Christine Labreze, J.-P. Venetz, Agustin Llopis, Aiko Miyahara, Jürgen Quietzsch, Sylvie De Maricourt, Rahman Nazari, Sofia Georgala, Nicolas Dupin, Venkata Putcha, E. Laffitte, L. Garcia Martinez, Hans-Peter Baum, Maria Morales, Hassan Seirafi, Behrooz Kasraee, Diamant Thaçi, Jann Lübbe, Luca Borradori, Christian Surber, Dominique Bonneau, Laurence Doelker, Christian Tran, E. Counillon, F. Vandenbos, Dan Lipsker, Günter Burg, Gürkan Kaya, Renato G. Panizzon, Helen S. Evans, Ute Jacobi, Evelyne Leemans, Eva M. Valesky, Mohammad Reza Fallahi, Katharina Spanaus Schlapbach, Roland Blum, Isabelle Gorin, N. Widmer, Reinhard Dummer, J.L. Arranz López, M.A. Duchosal, Karin Thoss, Wolfram Sterry, Carolina Pellanda, H. Zeller, Shinji Shimada, Emmanuel Molinari, Akiko Nagasaka, J.-M. Pönnighaus, T. Kovacsovics, Julie De Quatrebarbes, Daniel Mischke, Mohammad Nikbakhsh, Giovanni Luigi Capella, Hans-Uwe Simon, J.-H. Saurat, Julien Gautier, Naohito Hatta, Jörg Willers, Heidrun Ziegler, Günther F.L. Hofbauer, Philippe Revel, N. Kunzle, Pierre Vabres, P. Lesavre, Mitra Amini, Maryam Akhyani, Farhad Handjani, M. Pascual, Jürgen Lademann, Uwe Trefzer, Roland Kaufmann, Thomas Elshorst-Schmidt, Arash Taheri, Andreas J. Bircher, Parisa Mansoori, Jørn Olsen, Hiroyuki Matsue, E. Gambillara, Alexander C. Katoulis, Jean-Hilaire Saurat, H. Zachariae, Isabelle Daigle, T. Rodriguez Bravo, Christos C. Zouboulis, and Olivier Sorg

Subjects
Medical education, Acknowledgement, Dermatology, Psychology
Published
2005
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