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1. Characterisation of type 2 diabetes subgroups at diagnosis: the COPERNICAN prospective observational cohort study protocol

Author

Marta Hernandez, Josep Franch-Nadal, Didac Mauricio, Minerva Granado-Casas, Àngels Molló, Paula Garcia, Francesc Xavier Cos Claramunt, Bogdan Vlacho, Berta Fernandez-Camins, Albert Canudas, Marta Ortega, Alexandre Perera-LLuna, Alejandro Boluda-Sanson, Yesmina El-Khattabi-Ofkir, Idoia Genua Trullos, Inka Miñambres, Natalia Riera, Antonia Valsera Robles, M Eulalia Pradas Sala, Norma Ballestar Palacios, Olga Vazquez Soler, Cristina Ledesma Serrano, Ana Cámara Caño, Teresa Villuendas, Begona Ribas Lopez, Ana Maria Pedro Pijoan, Eva Gonzalez Platas, Eva Garcia, Raquel Martí, Eva Serra Llavall, Montserrat Torra Solé, Maite Puig Solé, Ana Isabel Areny Tallaví, Marc Olivart, Neus Miro Vallve, Marta Puig Fito, Jesús Pujol Salud, Cristina Garcia Serrano, Eva Miquel Fernàndez, Lidia Aran Sole, Antonieta Lafarga, Cristina Dominguez Amador, Sandra Guerrero, Cristina Farras Salles, Maria Boldú Franque, Lorena Arnay, Mireia Marin, Laura Turo Pere, Anna Maria Torné Cortés, Laia Llubes Arrià, Cecilia Bañeres Argiles, Assumpció Florensa Flix, Manuel Mata Cases, Carla Muñoz, Isabel Bobe, Elena Hernández Boluda, María Begoña Cañas Diaz, Xavier Peligros Palma, Francisco Cegri Lombando, Anna Martinez Sanchez, Gabriel Cuatrecasas, Anna Amorós, Blanca Simon, Anna Massana Raurich, Maria Isabel Prieto Fernández, Maria Olga Alvarez Fernández, Robert Cabanes Gómez, Ascensión Niubo Lopez, Marta Crespo Boixasa, Assumpció Altaba Barcelo, Estel Felez Carroba, Carme Olius Peyrats, Eva Marsol Prieto, Eva Ferris Gallart, Maria Lluïsa Calonge Carbonell, Roser Ros Barnadas, Elena Artal Traveria, Zulema Martí Oltra, Carolina Lapena Estella, Olga Poveda Jovellar, Ana Carrera Rodriguez, Sonia Aldea Gomez, Xavier Herraiz Fabregat, Elisabet Llop Lozano, Ignacio Alborch Simó, Laura Güell Espigol, Pilar Pedro Benages, Javier Parramon Nuñez, Paloma Prats, Berta Tió, Carlos Arias, Pelayo Martinez, Cristian Llacer Pinos, Roser Ferrer Costa, and Luz Maria Cruz Carlo

Subjects
Medicine
Abstract

Introduction Type 2 diabetes mellitus (T2DM) is a highly heterogeneous and complex metabolic disease harbouring different metabolic characteristics. Adequate characterisation of subjects is essential to allow the implementation of precision medicine for the prevention, diagnosis, prognosis and treatment of this condition.Methods and analysis This prospective observational cohort study aims to identify and characterise relevant clinical clusters that are reproducibly associated with various clinical outcomes in T2DM in our Mediterranean region. The COPERNICAN study will include 1200 subjects with newly diagnosed T2DM from 28 primary care centres from the city of Barcelona and the healthcare district of Lleida in Catalonia (Spain). Participants will undergo a comprehensive phenotypic evaluation including, among others, six relevant variables: age, antibodies against glutamic acid decarboxylase, body mass index, glycated haemoglobin (HbA1c), indexes of insulin sensibility (HOMA2-IR) and secretion (HOMA2-beta). We will collect additional comprehensive data on glucose-lowering and other drug treatments, clinical evaluation (including complications), laboratory parameters, advanced lipoprotein profile, dietary habits and physical activity. The linkage with the population database will be done to perform a pragmatic follow-up of participants as part of their usual clinical care. A state-of-the-art cluster analysis (k-means and hierarchical clustering) will be performed.Ethics and dissemination The present study complies with all the ethical aspects and protection of participant subjects complying with all current local and European Union legislation. All Ethics Committees from the institutions involved in the study (IR Sant Pau Ethics Committee, Ethics Committee for Drug Research at IDIAP Jordi Gol and University Hospital of Bellvitge Ethics Committee for Research) approved this protocol. Confidentiality and anonymity of the data are ensured according to the current Spanish Organic Law 3/2018 of 05 December.Trial registration number ClinicalTrials.gov. registration number NCT05333718, 27 January 2023.

Published
2024
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2. Evaluación de una intervención de promoción de la salud para personas mayores de barrios desfavorecidos

Author

José Luis del Val García, Xavier Continente, María José López Medina, Carolina Lapena Estella, Vicencia Laguna Fernández, and Alba Sánchez Mascuñano

Subjects
Diet habits, Elderly persons, Psychological intervention, Physical activity, Salud mental, Apoyo social, Psychology, Humanities, Predimed, General Nursing
Abstract

espanolObjetivo: evaluar la efectividad de una intervencion de promocion de la salud para personas de edad avanzada, con el objetivo de promover la adopcion de habitos saludables y de mejorar la calidad de vida relacionada con la salud (CVRS), la salud mental y el apoyo social. Metodo: se llevo a cabo un estudio de evaluacion con diseno pre/post, no-experimental. Se trataba de captar a mayores de 65 anos, residentes en la comunidad, de dos barrios de nivel socioeconomico desfavorecido de la ciudad de Barcelona. La intervencion consistio en un taller estructurado en ocho sesiones cuyo objetivo era la adopcion de habitos saludables. Se obtuvo informacion sobre la actividad fisica, CVRS, habitos dieteticos, salud mental y apoyo social a partir de cuestionarios validados (IPAQ, SF-36, PREDIMED, GHQ-12, MOS y NSHAP, respectivamente). Se analizaron diferencias antes y despues de la intervencion mediante los test de McNemar, t de Student y de Wilcoxon para datos apareados segun correspondiese. Resultados: la muestra se compuso de 22 adultos. Tras la intervencion, la mediana de actividad fisica se incremento en 842,5 MET/semana. La CVRS tambien mejoro: las puntuaciones para dimension mental se incrementaron en un 30% y las de la dimension fisica un 22%. No se observaron cambios en la dieta o en la salud mental. Conclusiones: las intervenciones de promocion de la salud, orientadas a personas mayores pueden jugar un papel clave en la mejora de la calidad de vida y el bienestar. EnglishObjective: to assess the efficacy of a health promotion intervention for persons of advanced age, with the objective of promoting the adoption of healthy habits and improving health-related quality of life (HRQoL), mental health, and social support. Methods: an evaluation study was conducted with pre/post, non-experimental design. The objective was to recruit >65-year-old persons living in the community, from two areas in the city of Barcelona with underprivileged socioeconomic levels. The intervention consisted in a workshop structured into eight sessions, with the objective of adopting healthy habits. Information was collected about physical activity, HRQoL, diet habits, mental health, and social support, through validated questionnaires (IPAQ, SF-36, PREDIMED, GHQ-12, MOS and NSHAP, respectively). Any differences before and after the intervention were analyzed through the McNemar, Student’s t and Wilcoxon tests for paired data, as relevant. Results: the sample included 22 adults. After the intervention, there was an increase in the median physical activity of 842.5 MET/week. There was also an improvement in HRQoL: the scores for the mental dimension increased by 30% and the physical dimension by 22%. No changes were observed in diet or mental health. Conclusions: health promotion interventions, oriented to elderly persons, can play a key role in the improvement of QoL and wellbeing.

Published
2019
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