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Biostimulators are substances that stimulate collagen production when injected into the skin, they can be used to restore volume in the long term and reduce sagging. Calcium Hydroxyapatite - CaHA is present in teeth and bones, it is a biocompatible product with high degree of safety due to the low inflammatory response verified by the smooth surface and regular size of the microparticles, presenting the advantage of being normally produced in the human body. Besides this, it provides volume replacement and collagen biostimulation, it is a biodegradable material, and it is naturally reabsorbed by the host’s metabolic processes, being able to immediately restore volume, in addition to filling and correcting specific creases and cavities. It is ideal for use in all areas of the face except the glabella, periorbital area and lips. Poly-L-lactic Acid (PLLA) is a semipermanent filler with results of approximately four years and it is also biodegradable. The general objective of this study is to analyze the advantages and differences between the CaHA better known by the trademark Diamond and Radiesse and the PLLA known by the trademark Elleva and Sculptra. For this we used qualitative research whose main method is the bibliographic study with literature review in books and articles on the subject. Data collection was carried out through websites (Google Academic and SciELO) with the following descriptors: Biostimulators, Calcium Hydroxyapatite, Poly-L-lactic and Collagen, having as inclusion criteria scientific articles that have analyzed the differences and similarities between CaHA and PLLA, besides the main products used in order to facilitate their choice in facial harmonization treatments. The exclusion criteria included articles repeated on both sites and articles with publication period prior to 2009. The results indicated that the Elleva product from the Rennova brand, which has PLLA as an active ingredient, presented more benefits in relation to its competitor brand the Sculptra.

Parabens are among the most widely used preservatives in cosmetic formulations. The aim of this study was to investigate the relationship between allergic contact dermatitis (ACD) and the use of parabens in cosmetics. A systematic review was performed with searches in PubMed, Scopus and Science Direct, in addition to a manual search. Interventional or observational studies that assessed the incidence of ACD in individuals using parabens were included. The quality of the articles was assessed and the data were extracted for a qualitative synthesis and single-arm meta-analysis. Fourteen studies (8 longitudinal, 3 cross-sectional, 1 quasi experimental and 2 case reports) were included in the systematic review and had their data extracted. Twelve studies reported ACD after the use of parabens and were included in the single-arm meta-analysis, resulting in an ACD incidence of 0.9%[95%CI: 0.4-2.0%], thus classified as a rare event. This result was related to already sensitized skin in most cases. In addition, the concentration of parabens in the contact test was above that recommended in cosmetics. The incidence of ACD due to parabens is rare, but further studies with control groups and at the usual concentrations of parabens are needed to better evaluate the results.

Orientadora Profa. Dra. Astrid Wiens Souza Coorientadora Profa. Dra. Daniela Florêncio Maluf Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa : Curitiba, 20/02/2020 Inclui referências: p. 72-79 Resumo: Dentre os conservantes mais utilizados em formulações farmacêuticas e cosméticas, destacam-se os parabenos (ésteres de alquil de ácido para-hidroxibenzóico). Apesar de serem substâncias amplamente utilizadas devido suas vantagens, facilidade de uso, compatibilidade com diferentes formulações cosméticas, baixo custo e boa eficácia, existem controvérsias sobre sua segurança para a saúde humana. A dermatite alérgica de contato (DAC) é uma dermatose inflamatória considerada uma das doenças ocupacionais mais comuns, sendo caracterizada por eritema, pápulas e vesículas, seguidas de ressecamento e descamação. É causada por meio de agentes externos que desencadeiam reação inflamatória em contato com a pele. O objetivo desse estudo foi investigar a relação da DAC com o uso dos parabenos em cosméticos. Para isso, foi realizada uma revisão sistemática (RS) da literatura com meta-análise. As buscas foram realizadas no Pubmed, Scopus e Science Direct, além da busca manual nas referências dos estudos e em registros não indexados. Artigos publicados em caracteres não romanos e artigos não disponíveis na íntegra em nenhuma base de dados foram excluídos. As etapas da RS foram realizadas por dois revisores independentes, seguidas de consenso, e em caso de discordância outro pesquisador foi contatado. A meta-análise foi realizada no software CMA. A busca gerou 3.351 artigos, totalizando 3.339 após a exclusão de duplicatas. Após a etapa da triagem 110 estudos foram selecionados para leitura na íntegra, dos quais 14 tiveram os dados extraídos (8 observacionais retrospectivos, 2 descritivos observacionais, 1 observacional transversal, 1 quasi experimental e 2 relatos de caso). Destes, 12 estudos reportaram DAC frente ao uso dos parabenos, porém com baixa frequência (em um estudo com dados de 69.487 indivíduos, 1% foi positivo aos parabenos), e esses resultados positivos podem estar relacionados a uma sensibilização de pele já pré-existente. A meta-análise de braço único foi realizada com os 12 estudos observacionais. A análise quantitativa mostrou que a reação alérgica com o uso de produtos cosméticos contendo parabenos existe, sendo uma prevalência de 9 positivos em 1000 indivíduos, todavia este resultado está relacionado a uma pele já sensibilizada na maioria dos casos. Ainda que exista uma polêmica que envolve o uso dos parabenos em cosméticos, não há evidências robustas de que o uso destas substâncias possa não ser seguro para a saúde humana, especialmente considerando a DAC. Abstract: Among the most used preservatives in pharmaceutical and cosmetic formulations, parabens (parahydroxybenzoic acid alkyl esters) stand out. Despite being widely used substances due to their advantages, ease of use, compatibility with different cosmetic formulations, low cost and good effectiveness, there are controversies about their safety for human health. Allergic contact dermatitis (ACD) is an inflammatory dermatosis considered one of the most common occupational diseases, being characterized by erythema, papules and vesicles, followed by dryness and desquamation. It is caused by external agents that trigger inflammatory reaction in contact with the skin. The aim of this study was to investigate the relationship between ACD and the use of parabens in cosmetics. For this, a systematic review (SR) of the literature was carried out with meta-analysis. The searches were performed in Pubmed, Scopus and Science Direct, in addition to the manual search in the study references and in non-indexed records. Articles published in non-Roman characters and articles not available in full in any database were excluded. The SR steps were carried out by two independent reviewers, followed by consensus, and in case of disagreement, another researcher was contacted. The meta-analysis was performed using the Comprehensive Meta-Analysis software (CMA). The search generated 3,351 articles, totaling 3,339 after excluding duplicates. After the screening stage, 110 studies were selected for full reading, of which 14 had the data extracted (8 retrospective observational, 2 observational descriptive, 1 cross-sectional observational, 1 quasi experimental and 2 case reports). Of these, 12 studies reported ACD against the use of parabens, but with low frequency (in a study with data of 69,487 individuals, 1% was positive for parabens), and these positive results may be related to pre-existing skin sensitization. The single-arm meta-analysis was performed with the 12 observational studies. Quantitative analysis showed that the allergic reaction with the use of cosmetic products containing parabens exists, with a prevalence of 9 positives in 1000 individuals, however this result is related to a skin already sensitized in most cases. Although there is a controversy surrounding the use of parabens in cosmetics, there is no robust evidence that the use of these substances may not be safe for human health, especially considering ACD.