1. Alternative radiopacifiers for polymethyl methacrylate bone cements: Silane-treated anatase titanium dioxide and yttria-stabilised zirconium dioxide
- Author
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Carole Elford, Panagiota Manti, Wayne Nishio Ayre, Ravi Mitha, Bronwen Evans, Rhidian Morgan-Jones, James Caradoc Birchall, Jeff Rowlands, Wendy Gillian Rowe, Samuel Lewin Evans, Stephen Paul Denyer, Paul Malpas, Catherine Avril Holt, and Nicole Scully
- Subjects
Anatase ,Materials science ,Compressive Strength ,Cell Survival ,silane ,0206 medical engineering ,Biomedical Engineering ,02 engineering and technology ,Cell Line ,Biomaterials ,Mice ,chemistry.chemical_compound ,biocompatibility ,Fracture toughness ,Coated Materials, Biocompatible ,Flexural strength ,Cell Adhesion ,Animals ,Polymethyl Methacrylate ,Yttrium ,mechanical ,Particle Size ,Composite material ,Titanium ,Cement ,bone cement ,Zirconium dioxide ,Flexural modulus ,Bone Cements ,technology, industry, and agriculture ,toxicity ,Silanes ,021001 nanoscience & nanotechnology ,Bone cement ,equipment and supplies ,PMMA ,020601 biomedical engineering ,Silane ,Biomaterials Processing ,chemistry ,radiopacifier ,Stress, Mechanical ,Zirconium ,Barium Sulfate ,0210 nano-technology - Abstract
Poly (methyl methacrylate) (PMMA) bone cement is widely used for anchoring joint arthroplasties. In cement brands approved for these procedures, micron-sized particles (usually barium sulphate, BaSO4) act as the radiopacifier. It has been postulated that these particles act as sites for crack initiation and subsequently cement fatigue. This study investigated whether alternative radiopacifiers, anatase titanium dioxide (TiO2) and yttria-stabilised zirconium dioxide (ZrO2), could improve the in vitro mechanical, fatigue crack propagation and biological properties of polymethyl methacrylate (PMMA) bone cement and whether their coating with a silane could further enhance cement performance. Cement samples containing 0, 5, 10, 15, 20 and 25%w/w TiO2or ZrO2and 10%w/w silane-treated TiO2or ZrO2were prepared and characterised in vitro in terms of radiopacity, compressive and bending strength, bending modulus, fatigue crack propagation, hydroxyapatite forming ability and MC3T3-E1 cell attachment and viability. Cement samples with greater than 10%w/w TiO2and ZrO2had a similar radiopacity to the control 10%w/w BaSO4cement and commercial products. The addition of TiO2and ZrO2to bone cement reduced the bending strength and fracture toughness and increased fatigue crack propagation due to the formation of agglomerations and voids. Silane treating TiO2reversed this effect, enhancing the dispersion and adhesion of particles to the PMMA matrix and resulted in improved mechanical properties and fatigue crack propagation resistance. Silane-treated TiO2cements had increased nucleation of hydroxyapatite and MC3T3-E1 cell attachment in vitro, without significantly compromising cell viability. This research has demonstrated that 10%w/w silane-treated anatase TiO2is a promising alternative radiopacifier for PMMA bone cement offering additional benefits over conventional BaSO4radiopacifiers.
- Published
- 2021