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4. Recommandations du Comité d’andrologie et de médecine sexuelle de l’AFU concernant la prise en charge andrologique et en médecine sexuelle en contexte et en sortie de crise sanitaire liée au COVID-19

Author

Burte, C., Chevallier, D., Delaunay, B., Droupy, S., El Osta, R., Game, X., Gayrel, P., Giuliano, F., Izard, V., Mallet, R., Ruffion, A., Salin, A., Savareux, L., Staerman, F., Huyghe, E., Graziana, J.P., Methorst, C., Morel Journel, N., Terrier, J.E., Marcelli, F., Madec, F.X., Yiou, R., Akakpo, W., Hupertan, V., Carnicelli, D., Beley, S., Ferretti, L., and Faix, A.

Published
2021
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15. Résultats chirurgicaux de l’implantation de prothèse gonflable 475ZSI après phalloplastie

Author

Marchand, S., Morel-Journel, N., Carnicelli, D., Boucher, F., Ruffion, A., and Neuville, P.

Abstract

La prothèse ZSI475FtM a été conçue pour répondre au mieux aux contraintes anatomiques des phalloplasties. Cette étude a pour but de présenter les résultats chirurgicaux et complications après implantation d’un large nombre de ces prothèses sur phalloplasties.

Published
2024
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16. Évaluation du potentiel régénératif de la veine de cordon ombilical comme tissu de reconstruction urétrale chez le lapin : une étude préclinique

Author

Parat, C., Carnicelli, D., Morel-Journel, N., Sbizerra, M., Chen, Y., Barrot, L., Langonnet, S., and Neuville, P.

Abstract

Le développement de l’ingénierie tissulaire offre une alternative à l’utilisation des autogreffes dans les urétroplasties, en recherchant le tissu idéal (échafaudage tissulaire, cellules souches, facteurs de croissance). Le tissu idéal n’a pas été trouvé et la muqueuse buccale demeure le tissu de référence malgré ses complications associées. Les greffes amniotiques semblent prometteuses en raison de leurs propriétés anti-inflammatoire, anti-fibrotique, non-immunogène. La veine de cordon ombilical est également prometteuse comme le montre son utilisation dans la régénération nerveuse.

Published
2024
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18. Plasmonic Metasurfaces for Specific SERS Detection of Shiga Toxins

Author

Rippa, M., primary, Sagnelli, D., additional, Vestri, A., additional, Marchesano, V., additional, Munari, B., additional, Carnicelli, D., additional, Varrone, E., additional, Brigotti, M., additional, Tozzoli, R., additional, Montalbano, M., additional, Morabito, S., additional, Zhou, J., additional, Zyss, J., additional, and Petti, L., additional

Published
2022
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19. Extracellular Vesicles and Renal Endothelial Cells: A Fatal Attraction in Hemolytic Uremic Syndrome

Author

Varrone E., Carnicelli D., Brigotti M., Varrone E., Carnicelli D., and Brigotti M.

Subjects
Endothelial Cell, Erythrocytes, Shiga-Toxigenic Escherichia coli, Extracellular Vesicle, Neutrophils, Neutrophil, Endothelial Cells, Escherichia coli Infection, Anemia, Acute Kidney Injury, Monocyte, Thrombocytopenia, Monocytes, Erythrocyte, Extracellular Vesicles, hemic and lymphatic diseases, Hemolytic-Uremic Syndrome, Humans, Escherichia coli Infections, Human
Abstract

This review focuses on typical hemolytic uremic syndrome (HUS), a life-threatening sequela of human infections caused, particularly in children, by Shiga toxin–producing Escherichia coli strains. Thrombotic microangiopathy of the brain and the kidney is the end point of toxin action, resulting in the hallmarks of HUS (ie, thrombocytopenia, anemia, and acute renal failure). A growing body of evidence points to the role of extracellular vesicles released in the blood of patients by toxin-challenged circulating cells (monocytes, neutrophils, and erythrocytes) and platelets, as a key factor in the pathogenesis of HUS. This review provides i) an updated description of the pathogenesis of Shiga toxin–producing E. coli infections; ii) an analysis of blood cell–derived extracellular vesicles, and of their parent cells, as triggering factors in HUS; and iii) a model explaining why Shiga toxin–containing vesicles dock preferentially to the endothelia of target organs.

Published
2020

26. Recommandations du Comité d’andrologie et de médecine sexuelle de l’AFU concernant la prise en charge andrologique et en médecine sexuelle en contexte et en sortie de crise sanitaire liée au COVID-19

Author

Huyghe, E., primary, Graziana, J.P., additional, Methorst, C., additional, Morel Journel, N., additional, Terrier, J.E., additional, Marcelli, F., additional, Madec, F.X., additional, Yiou, R., additional, Akakpo, W., additional, Hupertan, V., additional, Carnicelli, D., additional, Beley, S., additional, Ferretti, L., additional, Faix, A., additional, Burte, C., additional, Chevallier, D., additional, Delaunay, B., additional, Droupy, S., additional, El Osta, R., additional, Game, X., additional, Gayrel, P., additional, Giuliano, F., additional, Izard, V., additional, Mallet, R., additional, Ruffion, A., additional, Salin, A., additional, Savareux, L., additional, and Staerman, F., additional

Published
2021
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32. The structure of the Shiga toxin 2a A‐subunit dictates the interactions of the toxin with blood components

Author

Brigotti M., Orth-Holler D., Carnicelli D., Porcellini E., Galassi E., Tazzari P. L., Ricci F., Manoli F., Manet I., Talasz H., Lindner H. H., Speth C., Erbeznik T., Fuchs S., Posch W., Chatterjee S., Wurzner R., Brigotti M., Orth-Holler D., Carnicelli D., Porcellini E., Galassi E., Tazzari P.L., Ricci F., Manoli F., Manet I., Talasz H., Lindner H.H., Speth C., Erbeznik T., Fuchs S., Posch W., Chatterjee S., and Wurzner R.

Subjects
Blood Platelets, protein fluorescence, Neutrophils, Protein Conformation, Circular Dichroism, Trihexosylceramides, shiga toxin, Hemolytic uremic syndrome, Shiga toxin-producing Escherichia coli, bacterial toxins, complement factor H, neutrophils, Shiga Toxin 2, Fluorescence, Complement Factor H, Chlorocebus aethiops, Escherichia coli, Leukocytes, Animals, Humans, Trypsin, Vero Cells, Research Articles, Research Article, Protein Binding
Abstract

Hemolytic uremic syndrome (eHUS) is a severe complication of human infections with Shiga toxins (Stxs)‐producing Escherichia coli. A key step in the pathogenesis of eHUS is the interaction of Stxs with blood components before the targeting of renal endothelial cells. Here, we show that a single proteolytic cleavage in the Stx2a A‐subunit, resulting into two fragments (A1 and A2) linked by a disulfide bridge (cleaved Stx2a), dictates different binding abilities. Uncleaved Stx2a was confirmed to bind to human neutrophils and to trigger leukocyte/platelet aggregate formation, whereas cleaved Stx2a was ineffective. Conversely, binding of complement factor H was confirmed for cleaved Stx2a and not for uncleaved Stx2a. It is worth noting that uncleaved and cleaved Stx2a showed no differences in cytotoxicity for Vero cells or Raji cells, structural conformation, and contaminating endotoxin. These results have been obtained by comparing two Stx2a batches, purified in different laboratories by using different protocols, termed Stx2a(cl; cleaved toxin, Innsbruck) and Stx2a(uncl; uncleaved toxin, Bologna). Stx2a(uncl) behaved as Stx2a(cl) after mild trypsin treatment. In this light, previous controversial results obtained with purified Stx2a has to be critically re‐evaluated; furthermore, characterisation of the structure of circulating Stx2a is mandatory to understand eHUS‐pathogenesis and to develop therapeutic approaches.

Published
2019

33. Pénis « en bloc », prélèvement et greffe : une étude cadavérique

Author

Fourel, M., Badet, L., Ruffion, A., Carnicelli, D., Chaffanjon, P., Fiard, G., Airoldi, S., Morel-Journel, N., and Neuville, P.

Abstract

La reconstruction totale de verge a été limitée à la phalloplastie jusqu’à la réalisation des premières allotransplantations péniennes dont les résultats ont été prometteurs. Ces greffes de verge ont toutes été réalisées à partir d’un prélèvement segmentaire du greffon. Un prélèvement « en bloc » pourrait éventuellement étendre les indications de greffes chez des personnes avec un déficit de pénis plus étendu, et limiter le nombre d’anastomoses microchirurgicales lors de la greffe.

Published
2024
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47. Blunt renal trauma with rupture of the urinary tract: Are there still indications for endoscopic management?

Author

Overs, C., primary, Fiard, G., additional, Rambeaud, J.J., additional, Boillot, B., additional, Terrier, N., additional, Thuillier, C., additional, Pic, G., additional, Lee, J.W., additional, Peilleron, N., additional, Carnicelli, D., additional, Poncet, D., additional, Franquet, Q., additional, Lanchon, C., additional, Lefrancq, J.B., additional, Grisard, S., additional, Long, J.A., additional, and Descotes, J.L., additional

Published
2017
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48. Récidive biochimique après traitement curatif d’un adénocarcinome prostatique localisé : intérêt de la TEP à la choline dans l’évaluation de la récidive locale

Author

Poncet, D., Arnoux, V., Descotes, J.-L., Rambeaud, J.-J., Verry, C., Terrier, N., Boillot, B., Dubreuil, J., Lanchon, C., Carnicelli, D., Fiard, G., Long, J.-A., Service d'urologie [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-IMAG-GMCAO), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Service de radiothérapie- CHU de Grenoble, CHU Grenoble, and Service de médecine nucléaire [CHU Grenoble]

Subjects
Prostate cancer, Recurrence, Tomographie à émission de positons, Positron emission tomography (PET), [SDV]Life Sciences [q-bio], Récidive biochimique, Cancer de prostate, Biochemical relapse, Choline
Abstract

International audience; OBJECTIVE:To establish 18 fluorocholine-positron emission tomography/computed tomography (F-PET/CT) performances for the detection of local recurrence in a population of patients with biochemical failure after primary curative treatment for localized prostate carcinoma.MATERIAL AND METHOD:From February 2011 to February 2014, 55 patients underwent a F-PET/CT for biochemical relapse after primary radical therapy for prostate cancer localized or locally advanced. Primary therapies for prostate cancer were 19 radical prostatectomy, 18 radiotherapy, 13 radiotherapy with hormonal treatment, 3 brachytherapy. The median age was 65 years (50-79). The initial staging was 17 T1, 23 T2 and 15 T3, 52 were N0 and N1 3. The median PSA was 12 (3-127). The Gleason score was less than 7, equal to 7 and greater than 7 at 21, 25 and 9 patients respectively. The average time to recurrence was 69.5 months (8-147) with a median PSA of 2.9 ng/mL (0.48-41).RESULTS:In 42 cases, F-PET/CT showed uptake, suggesting a recurrence, metastatic (6), nodal (26) or local isolated (10). The focal uptake in PET commissioned in 5 cases prostate biopsy, confirming the histological recurrence of prostate cancer in 4 cases. Among the 10 patients with isolated local recurrence, 8 underwent salvage radiotherapy. Of the 13 cases where the (F-PET/CT) showed no recurrence, 7 multiparametric MRI were performed. The MRI showed a local recurrence in 3 patients, the diagnoses were confirmed with prostate biopsy for two of them.CONCLUSION:In our study, for the patients with biochemical relapse of prostate adenocarcinoma localized or locally advanced, (F-PET/CT) was able to detect local recurrence isolated in nearly half the cases but did not show sufficient sensitivity to exclude recurrence local if negative. It does not replace MRI or additional prostate biopsy.

Published
2015

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