1. Use of compounded hormone therapy in the United States: report of The North American Menopause Society Survey
- Author
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Gass, ML, Stuenkel, CA, Utian, WH, La Croix, AZ, Carnahan, R, Cauley, JA, Bea, JW, and Gray, SL
- Subjects
Bioidentical ,Compounded hormone therapy ,FDA ,Testosterone ,Medical and Health Sciences ,Obstetrics & Reproductive Medicine ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
Objective: A national survey was conducted to determine the extent of use of compounded hormone therapy(C-HT) and to characterize the differences between C-HT users and users of hormone therapy approved by the USFood and Drug Administration (FDA-HT users).Methods: This Internet survey enrolled 3,725 women aged 40 to 84 years who were postmenopausal orexperiencing the menopause transition. The sample was weighted slightly by age, region, education, and race toreflect population attributes based on US Census data.Results: Overall, 9% of women were current users of HT, and 28% of all respondents were ever-users of HT.C-HT users represented 31% of ever-users of HT, 35% of current users of HT, and 41% of ever-users aged 40 to 49years. Approximately 13% of ever-users indicated current or past use of testosterone. The most cited reason forusing HT was vasomotor symptoms ( 70%). Nonapproved indications for using HT were selected more often byC-HT users. There were four reports of endometrial cancer among the 326 C-HT users compared with none reportedamong the 738 FDA-HT users. Significance was not determined because of small numbers.Conclusions: This survey indicates substantial use of C-HT across the country and the possibility of higher ratesof endometrial side effects with such products. There is a need for standardized data collection on the extent of use ofcompounded hormones and their potential risks.
- Published
- 2023