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255 results on '"Carmona-Iragui, Maria"'

2. Correction: Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

Author

Zhu, Nuole, Santos-Santos, Miguel, Illán-Gala, Ignacio, Montal, Victor, Estellés, Teresa, Barroeta, Isabel, Altuna, Miren, Arranz, Javier, Muñoz, Laia, Belbin, Olivia, Sala, Isabel, Sánchez-Saudinós, Maria Belén, Subirana, Andrea, Videla, Laura, Pegueroles, Jordi, Blesa, Rafael, Clarimón, Jordi, Carmona-Iragui, Maria, Fortea, Juan, Lleó, Alberto, and Alcolea, Daniel

Published
2023
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3. Alzheimer's disease associated with Down syndrome: a genetic form of dementia

Author

Fortea, Juan, Zaman, Shahid H, Hartley, Sigan, Rafii, Michael S, Head, Elizabeth, and Carmona-Iragui, Maria

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Prevention, Clinical Research, Brain Disorders, Neurodegenerative, Alzheimer's Disease, Aging, Clinical Trials and Supportive Activities, Acquired Cognitive Impairment, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Intellectual and Developmental Disabilities (IDD), 2.1 Biological and endogenous factors, Aetiology, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Adult, Alzheimer Disease, Biomarkers, Down Syndrome, Humans, Intellectual Disability, Neurology & Neurosurgery, Clinical sciences
Abstract

Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's disease and are at very high risk of developing early-onset dementia, which is now the leading cause of death in this population. Diagnosis of dementia remains a clinical challenge because of the lack of validated diagnostic criteria in this population, and because symptoms are overshadowed by the intellectual disability associated with Down syndrome. In people with Down syndrome, fluid and imaging biomarkers have shown good diagnostic performances and a strikingly similar temporality of changes with respect to sporadic and autosomal dominant Alzheimer's disease. Most importantly, there are no treatments to prevent Alzheimer's disease, even though adults with Down syndrome could be an optimal population in whom to conduct Alzheimer's disease prevention trials. Unprecedented research activity in Down syndrome is rapidly changing this bleak scenario that will translate into disease-modifying therapies that could benefit other populations.

Published
2021

4. Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study

Author

Carmona-Iragui, Maria, Alcolea, Daniel, Barroeta, Isabel, Videla, Laura, Muñoz, Laia, Van Pelt, Kathyrn L, Schmitt, Frederick A, Lightner, Donita D, Koehl, Lisa M, Jicha, Gregory, Sacco, Silvia, Mircher, Clotilde, Pape, Sarah E, Hithersay, Rosalyn, Clare, Isabel CH, Holland, Anthony J, Nübling, Georg, Levin, Johannes, Zaman, Shahid H, Strydom, Andre, Rebillat, Anne-Sophie, Head, Elizabeth, Blesa, Rafael, Lleó, Alberto, and Fortea, Juan

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Prevention, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Neurodegenerative, Dementia, Clinical Research, Alzheimer's Disease, Brain Disorders, Aging, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Adult, Age Factors, Aged, Alzheimer Disease, Apolipoprotein E4, Cohort Studies, Disease Progression, Down Syndrome, Female, Humans, Intellectual Disability, Intermediate Filaments, Longitudinal Studies, Male, Middle Aged, Neurofilament Proteins, Predictive Value of Tests, Prognosis, ROC Curve, Sex Factors, Neurology & Neurosurgery, Clinical sciences
Abstract

BackgroundAdults with Down syndrome are at an ultra-high risk of Alzheimer's disease, but diagnosis of Alzheimer's disease in this population is challenging. We aimed to validate the clinical utility of plasma neurofilament light chain (NfL) for the diagnosis of symptomatic Alzheimer's disease in Down syndrome, assess its prognostic value, and establish longitudinal changes in adults with Down syndrome.MethodsWe did a multicentre cohort study, including adults with Down syndrome (≥18 years), recruited from six hospitals and university medical centres in France, Germany, Spain, the UK, and the USA, who had been assessed, followed up, and provided at least two plasma samples. Participants were classified by local clinicians, who were masked to biomarker data, as asymptomatic (ie, no clinical suspicion of Alzheimer's disease), prodromal Alzheimer's disease, or Alzheimer's disease dementia. We classified individuals who progressed along the Alzheimer's disease continuum during follow-up as progressors. Plasma samples were analysed retrospectively; NfL concentrations were measured centrally using commercial kits for biomarker detection. We used ANOVA to evaluate differences in baseline NfL concentrations, Cox regression to study their prognostic value, and linear mixed models to estimate longitudinal changes. To account for potential confounders, we included age, sex, and intellectual disability as covariates in the analyses.FindingsBetween Aug 2, 2010, and July 16, 2019, we analysed 608 samples from 236 people with Down syndrome: 165 (70%) were asymptomatic, 32 (14%) had prodromal Alzheimer's disease, and 29 (12%) had Alzheimer's disease dementia; ten [4%] participants were excluded because their classification was uncertain. Mean follow-up was 3·6 years (SD 1·6, range 0·6-9·2). Baseline plasma NfL concentrations showed an area under the receiver operating characteristic curve of 0·83 (95% CI 0·76-0·91) in the prodromal group and 0·94 (0·90-0·97) in the dementia group for differentiating from participants who were asymptomatic. An increase of 1 pg/mL in baseline NfL concentrations was associated with a 1·04-fold risk of clinical progression (95% CI 1·01-1·07; p=0·0034). Plasma NfL concentrations showed an annual increase of 3·0% (95% CI 0·4-5·8) per year in the asymptomatic non-progressors group, 11·5% (4·9-18·5) per year in the asymptomatic progressors group, and 16·0% (8·4-24·0) per year in the prodromal Alzheimer's disease progressors group. In participants with Alzheimer's disease dementia, NfL concentrations increased by a mean of 24·3% (15·3-34·1).InterpretationPlasma NfL concentrations have excellent diagnostic and prognostic performance for symptomatic Alzheimer's disease in Down syndrome. The longitudinal trajectory of plasma NfL supports its use as a theragnostic marker in clinical trials.FundingAC Immune, La Caixa Foundation, Instituto de Salud Carlos III, National Institute on Aging, Wellcome Trust, Jérôme Lejeune Foundation, Medical Research Council, National Institute for Health Research, EU Joint Programme-Neurodegenerative Disease Research, Alzheimer's society, Deutsche Forschungsgemeinschaft, Stiftung für die Erforschung von Verhaltens und Umwelteinflüssen auf die menschliche Gesundheit, and NHS National Institute of Health Research Applied Research Collaborations East of England, UK.

Published
2021

5. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.

Author

Dierssen, Mara, Herault, Yann, Helguera, Pablo, Martínez de Lagran, Maria, Vazquez, Anna, Christian, Bradley, Carmona-Iragui, Maria, Wiseman, Frances, Mobley, William, Fisher, Elizabeth MC, Brault, Veronique, Esbensen, Anna, Jacola, Lisa M, Potier, Marie Claude, Hamlett, Eric D, Abbeduto, Leonard, Del Hoyo Soriano, Laura, Busciglio, Jorge, Iulita, Maria Florencia, Crispino, John, Malinge, Sébastien, Barone, Eugenio, Perluigi, Marzia, Costanzo, Floriana, Delabar, Jean Maurice, Bartesaghi, Renata, Dekker, Alain D, De Deyn, Peter, Fortea Ormaechea, Juan, Shaw, Patricia A, Haydar, Tarik F, Sherman, Stephanie L, Strydom, André, and Bhattacharyya, Anita

Subjects
Alzheimer's disease, Biomarkers, Down syndrome, Intellectual disability, Language impairment, Mouse models, Neurodevelopmental disorders, Trisomy 21 Research Society, Alzheimer&#8217, s disease, Down Syndrome, Neurosciences, Brain Disorders, Cancer, Intellectual and Developmental Disabilities (IDD), 2.1 Biological and endogenous factors, Genetics, Clinical Sciences
Abstract

Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome. The Trisomy 21 Research Society (T21RS) is the premier scientific organization for researchers and clinicians studying Down syndrome. The Third International Conference of T21RS, held June 6-9, 2019, in Barcelona, Spain, brought together 429 scientists, families, and industry representatives to share the latest discoveries on underlying cellular and molecular mechanisms of T21, define cognitive and behavioral challenges and better understand comorbidities associated with Down syndrome, including Alzheimer's disease and leukemia. Presentation of cutting-edge results in neuroscience, neurology, model systems, psychology, cancer, biomarkers and molecular and phar-ma-cological therapeutic approaches demonstrate the compelling interest and continuing advancement in all aspects of understanding and ameliorating conditions associated with T21.

Published
2021

6. Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis

Author

Hostettler, Isabel Charlotte, Wilson, Duncan, Fiebelkorn, Catherine Arnold, Aum, Diane, Ameriso, Sebastián Francisco, Eberbach, Federico, Beitzke, Markus, Kleinig, Timothy, Phan, Thanh, Marchina, Sarah, Schneckenburger, Romain, Carmona-Iragui, Maria, Charidimou, Andreas, Mourand, Isabelle, Parreira, Sara, Ambler, Gareth, Jäger, Hans Rolf, Singhal, Shaloo, Ly, John, Ma, Henry, Touzé, Emmanuel, Geraldes, Ruth, Fonseca, Ana Catarina, Melo, Teresa, Labauge, Pierre, Lefèvre, Pierre-Henry, Viswanathan, Anand, Greenberg, Steven Mark, Fortea, Juan, Apoil, Marion, Boulanger, Marion, Viader, Fausto, Kumar, Sandeep, Srikanth, Velandai, Khurram, Ashan, Fazekas, Franz, Bruno, Veronica, Zipfel, Gregory Joseph, Refai, Daniel, Rabinstein, Alejandro, Graff-Radford, Jonathan, and Werring, David John

Published
2022
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7. Neural correlates of episodic memory in adults with Down syndrome and Alzheimer’s disease

Author

Benejam, Bessy, Aranha, Mateus Rozalem, Videla, Laura, Padilla, Concepción, Valldeneu, Silvia, Fernández, Susana, Altuna, Miren, Carmona-Iragui, Maria, Barroeta, Isabel, Iulita, Maria Florencia, Montal, Víctor, Pegueroles, Jordi, Bejanin, Alexandre, Giménez, Sandra, González-Ortiz, Sofía, Videla, Sebastián, Bartrés-Faz, David, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, and Fortea, Juan

Published
2022
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8. Characterization of white matter hyperintensities in Down syndrome.

Author

Morcillo‐Nieto, Alejandra O., Zsadanyi, Sara E., Arriola‐Infante, Jose E., Carmona‐Iragui, Maria, Montal, Victor, Pegueroles, Jordi, Aranha, Mateus Rozalem, Vaqué‐Alcázar, Lídia, Padilla, Concepción, Benejam, Bessy, Videla, Laura, Barroeta, Isabel, Fernandez, Susana, Altuna, Miren, Giménez, Sandra, González‐Ortiz, Sofía, Bargalló, Núria, Ribas, Laia, Arranz, Javier, and Torres, Soraya

Published
2024
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9. Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C survey

Author

Hüls, Anke, Costa, Alberto C.S., Dierssen, Mara, Baksh, R. Asaad, Bargagna, Stefania, Baumer, Nicole T., Brandão, Ana Claudia, Carfi, Angelo, Carmona-Iragui, Maria, Chicoine, Brian Allen, Ghosh, Sujay, Lakhanpaul, Monica, Manso, Coral, Mayer, Miguel-Angel, Ortega, Maria del Carmen, de Asua, Diego Real, Rebillat, Anne-Sophie, Russell, Lauren Ashley, Sgandurra, Giuseppina, Valentini, Diletta, Sherman, Stephanie L., and Strydom, Andre

Published
2021
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10. Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI

Author

Projectafdeling VCI, Neurologen, Brain, Circulatory Health, Aranha, Mateus Rozalem, Montal, Victor, van den Brink, Hilde, Pegueroles, Jordi, Carmona-Iragui, Maria, Videla, Laura, Maure Blesa, Lucia, Benejam, Bessy, Arranz, Javier, Valldeneu, Sílvia, Barroeta, Isabel, Fernández, Susana, Ribas, Laia, Alcolea, Daniel, González-Ortiz, Sofía, Bargalló, Núria, Biessels, Geert Jan, Blesa, Rafael, Lleó, Alberto, Coutinho, Artur Martins, Leite, Cláudia Costa, Bejanin, Alexandre, Fortea, Juan, Projectafdeling VCI, Neurologen, Brain, Circulatory Health, Aranha, Mateus Rozalem, Montal, Victor, van den Brink, Hilde, Pegueroles, Jordi, Carmona-Iragui, Maria, Videla, Laura, Maure Blesa, Lucia, Benejam, Bessy, Arranz, Javier, Valldeneu, Sílvia, Barroeta, Isabel, Fernández, Susana, Ribas, Laia, Alcolea, Daniel, González-Ortiz, Sofía, Bargalló, Núria, Biessels, Geert Jan, Blesa, Rafael, Lleó, Alberto, Coutinho, Artur Martins, Leite, Cláudia Costa, Bejanin, Alexandre, and Fortea, Juan

Published
2024

11. Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI

Author

Barcelona Supercomputing Center, Aranha, Mateus Rozalem, Montal, Victor, van den Brink, Hilde, Pegueroles, Jordi, Carmona Iragui, Maria, Barcelona Supercomputing Center, Aranha, Mateus Rozalem, Montal, Victor, van den Brink, Hilde, Pegueroles, Jordi, and Carmona Iragui, Maria

Abstract

BACKGROUND Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. METHODS We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS. RESULTS CMI prevalence was 11.8\% in DS, 4.7\% in controls, and 17.5\% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. DISCUSSION In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype. Highlights This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8\% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy., The authors want to acknowledge the Faculty of Medicine at the Autonomous University of Barcelona (Facultad de Medicina—Universitat Autónoma de Barcelona). The authors also thank all study participants and caregivers for their support and dedication. We also would like to thank the Fundació Catalana Síndrome de Down (https://fcsd.org/) for global support; Reyes Alcoverro, Marta Salinas, and Tania Martínez for administrative support; and Concepción Escola and Diana Garzón for nurse support. This study was funded by Alzheimer's Association Research Fellowship to Promote Diversity (AARF-D) Program (AARFD-21-852492) to MRA. It was also supported by the Fondo de Investigaciones Sanitario, Carlos III Health Institute (co-funded by European Regional Development Fund/European Social Fund - A way to make Europe / Investing in your future) (PI20/01473 to JF, PI13/01532, PI16/01825 to RB, PI18/00335 to MCI, PI18/00435 to DA, PI14/1561, PI20/01330 to AL, PI22/00307 to AB), the CIBERNED Program 1, the National Institutes of Health (NIH) (1R01AG056850-01A1; 3RF1AG056850-01S1; AG056850, R21AG056974, and R01AG061566 to JF), the Departament de Salut de la Generalitat de Catalunya, Fundación Tatiana Pérez de Guzmán el Bueno (IIBSP-DOW-2020-151 to JF), the European Union's Horizon 2020, “MES-CoBraD” (H2020-SC1-BHC-2018-2020 / GA 965422 to JF), Brightfocus, and Life Molecular Imaging (LMI) to JF. AB acknowledges support from a Miguel Servet grant (CP20/00038) from the Carlos III Health Institute. and the Alzheimer's Association (AARG-22-923680). MCI acknowledges support from the Alzheimer's Association and Global Brain Health Institute (GBHI_ALZ-18-543740), the Jérôme Lejeune Foundation (#1913 Cycle 2019B), and the Societat Catalana de Neurologia (Premi Beca Fundació SCN 2020). VM acknowledges support from Predoctoral grants from the Carlos III Health Institute (FI18/00275). JA was supported by the Río Hortega Fellowship from Carlos III Health Institute (CM21/00243). The sponsors had n, Peer Reviewed, "Article signat per 23 autors/es: Mateus Rozalem Aranha, Victor Montal, Hilde van den Brink, Jordi Pegueroles, Maria Carmona-Iragui, Laura Videla, Lucia Maure Blesa, Bessy Benejam, Javier Arranz, Sílvia Valldeneu, Isabel Barroeta, Susana Fernández, Laia Ribas, Daniel Alcolea, Sofía González-Ortiz, Núria Bargalló, Geert Jan Biessels, Rafael Blesa, Alberto Lleó, Artur Martins Coutinho, Cláudia Costa Leite, Alexandre Bejanin, Juan Fortea", Postprint (published version)

Published
2024

12. Cortical microinfarcts in adults with Down syndrome assessed with 3T‐MRI.

Author

Aranha, Mateus Rozalem, Montal, Victor, van den Brink, Hilde, Pegueroles, Jordi, Carmona‐Iragui, Maria, Videla, Laura, Maure Blesa, Lucia, Benejam, Bessy, Arranz, Javier, Valldeneu, Sílvia, Barroeta, Isabel, Fernández, Susana, Ribas, Laia, Alcolea, Daniel, González‐Ortiz, Sofía, Bargalló, Núria, Biessels, Geert Jan, Blesa, Rafael, Lleó, Alberto, and Coutinho, Artur Martins

Abstract

BACKGROUND: Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. METHODS: We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS. RESULTS: CMI prevalence was 11.8% in DS, 4.7% in controls, and 17.5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico‐subcortical infarcts, but not hemorrhagic lesions. DISCUSSION: In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype. Highlights: This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS).We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition.The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico‐subcortical infarcts, but not hemorrhagic lesions.In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Sequential grey matter atrophy related to Alzheimer’s disease in adults with Down’s syndrome

Author

Bejanin, Alexandre, primary, Morcillo‐Nieto, Alejandra O., additional, Zsadanyi, Sara E., additional, Montal, Victor, additional, Pegueroles, Jordi, additional, Carmona‐Iragui, Maria, additional, Aranha, Mateus Rozalem, additional, Vaqué‐Alcázar, Lídia, additional, Benejam, Bessy, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Fernandez, Susana, additional, Giménez, Sandra, additional, González‐Ortiz, Sofía, additional, Bargalló, Núria, additional, Ribas, Laia, additional, Arranz, Javier, additional, Rodríguez‐Baz, Íñigo, additional, Belbin, Olivia, additional, Alcolea, Daniel, additional, Blesa, Rafael, additional, Lleo, Alberto, additional, and Fortea, Juan, additional

Published
2023
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14. Adults with Down syndrome show quantitative sleep electroencephalogram patterns similar to those observed in patients with Alzheimer’s disease

Author

Giménez, Sandra, primary, Clos, Susana, additional, Serna, Leidy Y., additional, Carmona‐Iragui, Maria, additional, Benejam, Bessy, additional, Rojas, Monica, additional, Bejanin, Alexandre, additional, Arranz, Javier, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Aranha, Mateus Rozalem, additional, Morcillo‐Nieto, Alejandra O., additional, Zsadanyi, Sara E., additional, Mañanas, Miguel Angel, additional, Lleo, Alberto, additional, Romero, Sergio, additional, and Fortea, Juan, additional

Published
2023
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15. [18F]PI2620 tau deposition increases along the Alzheimer’s disease continuum in Down Syndrome and in presence of amyloid

Author

Pegueroles, Jordi, primary, Camacho, Valle, additional, Montal, Victor, additional, Bejanin, Alexandre, additional, Videla, Laura, additional, Aranha, Mateus Rozalem, additional, Benejam, Bessy, additional, Morcillo‐Nieto, Alejandra O., additional, Zsadanyi, Sara E., additional, Barroeta, Isabel, additional, Carmona‐Iragui, Maria, additional, Lleo, Alberto, additional, Flotats, Albert, additional, and Fortea, Juan, additional

Published
2023
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16. SEX EFFECTS ON THE QUALITY OF SLEEP IN DOWN SYNDROME

Author

Giménez, Sandra, primary, Clos, Susana, additional, Bejanin, Alexandre, additional, Carmona‐Iragui, Maria, additional, Arranz, Javier, additional, Benejam, Bessy, additional, Videla, Laura, additional, Fernandez, Susana, additional, Rodríguez‐Baz, Íñigo, additional, Barroeta, Isabel, additional, Lleo, Alberto, additional, and Fortea, Juan, additional

Published
2023
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17. Cortical microinfarcts along the Alzheimer’s disease continuum in adults with Down syndrome ‐ an update

Author

Aranha, Mateus Rozalem, primary, van den Brink, Hilde, additional, Bejanin, Alexandre, additional, Montal, Victor, additional, Pegueroles, Jordi, additional, Carmona‐Iragui, Maria, additional, Videla, Laura, additional, Benejam, Bessy, additional, Valldeneu, Sílvia, additional, Barroeta, Isabel, additional, Altuna, Miren, additional, Fernandez, Susana, additional, Garzón, Diana, additional, Padilla, Concepcion, additional, Iulita, M. Florencia, additional, Alcolea, Daniel, additional, González‐Ortiz, Sofía, additional, Blesa, Rafael, additional, Sánchez‐Valle, Raquel, additional, Biessels, Geert Jan, additional, Lleó, Alberto, additional, and Fortea, Juan, additional

Published
2023
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18. Bilingualism is associated with a later age of symptom onset in bilinguals with Alzheimer’s disease positive biomarkers

Author

Grasso, Stephanie M, primary, Marques‐Kiderle, Sonia Karin, additional, Calabria, Marco, additional, Sala, Isabel, additional, Rodríguez‐Baz, Íñigo, additional, Zhu, Nuole, additional, Arranz, Javier, additional, Rubio‐Guerra, Sara, additional, Illán‐Gala, Ignacio, additional, Carmona‐Iragui, Maria, additional, Alcolea, Daniel, additional, Fortea, Juan, additional, Lleo, Alberto, additional, and Santos‐Santos, Miguel A, additional

Published
2023
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19. Cognitive reserve in Down syndrome: a new opportunity to understand resilience in Alzheimer’s disease

Author

Vaqué‐Alcázar, Lídia, primary, Carmona‐Iragui, Maria, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Benejam, Bessy, additional, Rodríguez‐Baz, Íñigo, additional, Arranz, Javier, additional, Pegueroles, Jordi, additional, Lleó, Alberto, additional, Fortea, Juan, additional, and Bartrés‐Faz, David, additional

Published
2023
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20. Cerebral microbleeds in Down syndrome: association with demographic, genetic, fluid and imaging biomarkers of Alzheimer’s disease

Author

Zsadanyi, Sara E., primary, Morcillo‐Nieto, Alejandra O., additional, Aranha, Mateus Rozalem, additional, Aragón, Irina, additional, Montal, Victor, additional, Pegueroles, Jordi, additional, Vaqué‐Alcázar, Lídia, additional, Benejam, Bessy, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Fernandez, Susana, additional, Giménez, Sandra, additional, González‐Ortiz, Sofía, additional, Bargalló, Núria, additional, Ribas, Laia, additional, Arranz, Javier, additional, Rodríguez‐Baz, Íñigo, additional, Belbin, Olivia, additional, Alcolea, Daniel, additional, Blesa, Rafael, additional, Lleó, Alberto, additional, Fortea, Juan, additional, Carmona‐Iragui, Maria, additional, and Bejanin, Alexandre, additional

Published
2023
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21. Biofluid markers of Alzheimer’s disease‐associated CNS inflammation in adults with Down syndrome

Author

Belbin, Olivia, primary, Iulita, Maria Florencia, additional, Serrano‐Requena, Sara, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Benejam, Bessy, additional, Altuna, Miren, additional, Tamayo, Natalia Valle, additional, Cervantes‐Gonz, Alba, additional, Gil, Laia Lidón, additional, Dols‐Icardo, Oriol, additional, Bejanin, Alexandre, additional, Alcolea, Daniel, additional, Lleó, Alberto, additional, Fortea, Juan, additional, and Carmona‐Iragui, Maria, additional

Published
2023
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22. Longitudinal white matter hyperintensities in Down’s syndrome

Author

Morcillo‐Nieto, Alejandra O., primary, Zsadanyi, Sara E., additional, Montal, Victor, additional, Aranha, Mateus Rozalem, additional, Pegueroles, Jordi, additional, Vaqué‐Alcázar, Lídia, additional, Benejam, Bessy, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Fernandez, Susana, additional, Giménez, Sandra, additional, González‐Ortiz, Sofía, additional, Bargalló, Núria, additional, Ribas, Laia, additional, Arranz, Javier, additional, Belbin, Olivia, additional, Alcolea, Daniel, additional, Blesa, Rafael, additional, Carmona‐Iragui, Maria, additional, Fortea, Juan, additional, and Bejanin, Alexandre, additional

Published
2023
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23. VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome

Author

Lleó, Alberto, Carmona-Iragui, Maria, Videla, Laura, Fernández, Susana, Benejam, Bessy, Pegueroles, Jordi, Barroeta, Isabel, Altuna, Miren, Valldeneu, Silvia, Xiao, Mei-Fang, Xu, Desheng, Núñez-Llaves, Raúl, Querol-Vilaseca, Marta, Sirisi, Sònia, Bejanin, Alexandre, Iulita, M. Florencia, Clarimón, Jordi, Blesa, Rafael, Worley, Paul, Alcolea, Daniel, Fortea, Juan, and Belbin, Olivia

Published
2021
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24. Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

Author

Zhu, Nuole, Santos-Santos, Miguel, Illán-Gala, Ignacio, Montal, Victor, Estellés, Teresa, Barroeta, Isabel, Altuna, Miren, Arranz, Javier, Muñoz, Laia, Belbin, Olivia, Sala, Isabel, Sánchez-Saudinós, Maria Belén, Subirana, Andrea, Videla, Laura, Pegueroles, Jordi, Blesa, Rafael, Clarimón, Jordi, Carmona-Iragui, Maria, Fortea, Juan, Lleó, Alberto, and Alcolea, Daniel

Published
2021
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25. The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders

Author

Alcolea, Daniel, Clarimón, Jordi, Carmona-Iragui, María, Illán-Gala, Ignacio, Morenas-Rodríguez, Estrella, Barroeta, Isabel, Ribosa-Nogué, Roser, Sala, Isabel, Sánchez-Saudinós, M. Belén, Videla, Laura, Subirana, Andrea, Benejam, Bessy, Valldeneu, Sílvia, Fernández, Susana, Estellés, Teresa, Altuna, Miren, Santos-Santos, Miguel, García-Losada, Lídia, Bejanin, Alexandre, Pegueroles, Jordi, Montal, Víctor, Vilaplana, Eduard, Belbin, Olivia, Dols-Icardo, Oriol, Sirisi, Sònia, Querol-Vilaseca, Marta, Cervera-Carles, Laura, Muñoz, Laia, Núñez, Raúl, Torres, Soraya, Camacho, M. Valle, Carrió, Ignasi, Giménez, Sandra, Delaby, Constance, Rojas-Garcia, Ricard, Turon-Sans, Janina, Pagonabarraga, Javier, Jiménez, Amanda, Blesa, Rafael, Fortea, Juan, and Lleó, Alberto

Published
2019
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26. Screening for obstructive sleep apnea in patients with Down Syndrome

Author

Fortuna Gutierrez, Ana, primary, Podzamczer Valls, Ines, additional, Mayos Pérez, Mercè, additional, Clos Batet, Susana, additional, Videla Toro, Laura, additional, Carmona-Iragui, Maria, additional, Barroeta Espar, Isabel, additional, Arranz Martinez, Javier José, additional, Benejam Paul, Bessy, additional, Lleó Bisa, Alberto, additional, Fortea Ormaechea, Juan, additional, and Giménez Badia, Sandra, additional

Published
2023
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27. Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

Author

Fortea, Juan, Carmona-Iragui, María, Benejam, Bessy, Fernández, Susana, Videla, Laura, Barroeta, Isabel, Alcolea, Daniel, Pegueroles, Jordi, Muñoz, Laia, Belbin, Olivia, de Leon, Mony J, Maceski, Aleksandra Maleska, Hirtz, Christophe, Clarimón, Jordi, Videla, Sebastián, Delaby, Constance, Lehmann, Sylvain, Blesa, Rafael, and Lleó, Alberto

Published
2018
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28. Cortical microstructural changes along the Alzheimer's disease continuum

Author

Montal, Victor, Vilaplana, Eduard, Alcolea, Daniel, Pegueroles, Jordi, Pasternak, Ofer, González-Ortiz, Sofia, Clarimón, Jordi, Carmona-Iragui, María, Illán-Gala, Ignacio, Morenas-Rodríguez, Estrella, Ribosa-Nogué, Roser, Sala, Isabel, Sánchez-Saudinós, María-Belén, García-Sebastian, Maite, Villanúa, Jorge, Izagirre, Andrea, Estanga, Ainara, Ecay-Torres, Mirian, Iriondo, Ane, Clerigue, Montserrat, Tainta, Mikel, Pozueta, Ana, González, Andrea, Martínez-Heras, Eloy, Llufriu, Sara, Blesa, Rafael, Sanchez-Juan, Pascual, Martínez-Lage, Pablo, Lleó, Alberto, and Fortea, Juan

Published
2018
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31. Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease

Author

Carmona-Iragui, María, Balasa, Mircea, Benejam, Bessy, Alcolea, Daniel, Fernández, Susana, Videla, Laura, Sala, Isabel, Sánchez-Saudinós, María Belén, Morenas-Rodriguez, Estrella, Ribosa-Nogué, Roser, Illán-Gala, Ignacio, Gonzalez-Ortiz, Sofía, Clarimón, Jordi, Schmitt, Frederick, Powell, David K., Bosch, Beatriz, Lladó, Albert, Rafii, Michael S., Head, Elizabeth, Molinuevo, José Luis, Blesa, Rafael, Videla, Sebastián, Lleó, Alberto, Sánchez-Valle, Raquel, and Fortea, Juan

Published
2017
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34. Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

Author

Belbin, Olivia, Xiao, Mei-Fang, Xu, Desheng, Carmona-Iragui, Maria, Pegueroles, Jordi, Benejam, Bessy, Videla, Laura, Fernández, Susana, Barroeta, Isabel, Nuñez-Llaves, Raúl, Montal, Victor, Vilaplana, Eduard, Altuna, Miren, Clarimón, Jordi, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, Worley, Paul F., and Fortea, Juan

Published
2020
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35. Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

Author

Rozalem Aranha, Mateus, primary, Iulita, Maria Florencia, additional, Montal, Victor, additional, Pegueroles, Jordi, additional, Bejanin, Alexandre, additional, Vaqué‐Alcázar, Lídia, additional, Grothe, Michel J., additional, Carmona‐Iragui, Maria, additional, Videla, Laura, additional, Benejam, Bessy, additional, Arranz, Javier, additional, Padilla, Concepción, additional, Valldeneu, Sílvia, additional, Barroeta, Isabel, additional, Altuna, Miren, additional, Fernández, Susana, additional, Ribas, Laia, additional, Valle‐Tamayo, Natalia, additional, Alcolea, Daniel, additional, González‐Ortiz, Sofía, additional, Bargalló, Núria, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Blesa, Rafael, additional, Wisniewski, Thomas, additional, Busciglio, Jorge, additional, Cuello, A. Claudio, additional, Lleó, Alberto, additional, and Fortea, Juan, additional

Published
2023
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36. Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

Author

Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), National Institutes of Health (US), Generalitat de Catalunya, Fundación Tatiana Pérez de Guzmán el Bueno, European Commission, Alzheimer's Association, Societat Catalana de Neurologia, Swedish Research Council, European Research Council, Alzheimer Drug Discovery Foundation, Olav Thon Foundation, The Erling-Persson Family Foundation, Gamla Tjänarinnor Foundation, Dementia Research Institute (UK), Hjärnfonden, Government of Sweden, Aranha, Mateus Rozalem, Iulita, Maria Florencia, Montal, Victor, Pegueroles, Jordi, Bejanin, Alexandre, Vaqué-Alcázar, Lídia, Grothe, Michel J., Carmona-Iragui, Maria, Videla, Laura, Benejam, Bessy, Arranz, Javier, Padilla, Concepción, Valldeneu, Sílvia, Barroeta, Isabel, Altuna, Miren, Fernández, Susana, Ribas, Laia, Valle-Tamayo, Natalia, Alcolea, Daniel, González-Ortiz, Sofía, Bargalló, Núria, Zetterberg, Henrik, Blennow, Kaj, Blesa, Rafael, Wisniewski, Thomas, Busciglio, Jorge, Cuello, A. Claudio, Lleó, Alberto, Fortea, Juan, Instituto de Salud Carlos III, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), National Institutes of Health (US), Generalitat de Catalunya, Fundación Tatiana Pérez de Guzmán el Bueno, European Commission, Alzheimer's Association, Societat Catalana de Neurologia, Swedish Research Council, European Research Council, Alzheimer Drug Discovery Foundation, Olav Thon Foundation, The Erling-Persson Family Foundation, Gamla Tjänarinnor Foundation, Dementia Research Institute (UK), Hjärnfonden, Government of Sweden, Aranha, Mateus Rozalem, Iulita, Maria Florencia, Montal, Victor, Pegueroles, Jordi, Bejanin, Alexandre, Vaqué-Alcázar, Lídia, Grothe, Michel J., Carmona-Iragui, Maria, Videla, Laura, Benejam, Bessy, Arranz, Javier, Padilla, Concepción, Valldeneu, Sílvia, Barroeta, Isabel, Altuna, Miren, Fernández, Susana, Ribas, Laia, Valle-Tamayo, Natalia, Alcolea, Daniel, González-Ortiz, Sofía, Bargalló, Núria, Zetterberg, Henrik, Blennow, Kaj, Blesa, Rafael, Wisniewski, Thomas, Busciglio, Jorge, Cuello, A. Claudio, Lleó, Alberto, and Fortea, Juan

Abstract

[Background] Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS., [Methods] We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume., [Results] In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance., [Discussion] BF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.

Published
2023

38. Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

Author

Alcolea, Daniel, Vilaplana, Eduard, Pegueroles, Jordi, Montal, Victor, Sánchez-Juan, Pascual, González-Suárez, Andrea, Pozueta, Ana, Rodríguez-Rodríguez, Eloy, Bartrés-Faz, David, Vidal-Piñeiro, Dídac, González-Ortiz, Sofía, Medrano, Santiago, Carmona-Iragui, María, Sánchez-Saudinós, M<ce:sup loc='post">a</ce:sup>Belén, Sala, Isabel, Anton-Aguirre, Sofía, Sampedro, Frederic, Morenas-Rodríguez, Estrella, Clarimón, Jordi, Blesa, Rafael, Lleó, Alberto, and Fortea, Juan

Published
2015
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39. White matter hyperintensities in Down syndrome: associations with demographic, genetic, fluid and imaging biomarkers of Alzheimer's disease

Author

Morcillo‐Nieto, Alejandra O., primary, Zsadanyi, Sara E., additional, Carmona‐Iragui, Maria, additional, Montal, Victor, additional, Pegueroles, Jordi, additional, Aranha, Mateus Rozalem, additional, Padilla, Concepcion, additional, Benejam, Bessy, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Fernandez, Susana, additional, Altuna, Miren, additional, Giménez, Sandra, additional, González‐Ortiz, Sofía, additional, Bargalló, Núria, additional, Ribas, Laia, additional, Arranz, Javier, additional, Torres, Soraya, additional, Iulita, Maria Florencia, additional, Belbin, Olivia, additional, Camacho, Valle, additional, Alcolea, Daniel, additional, Blesa, Rafael, additional, Lleó, Alberto, additional, Fortea, Juan, additional, and Bejanin, Alexandre, additional

Published
2022
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40. Plasma NfL associated neurodegeneration in adults with Down syndrome

Author

Padilla, Concepcion, primary, Bejanin, Alexandre, additional, Montal, Victor, additional, Pegueroles, Jordi, additional, Carmona‐Iragui, Maria, additional, Aranha, Mateus Rozalem, additional, Vera, Elena, additional, Zua, Ania, additional, Videla, Laura, additional, Altuna, Miren, additional, Benejam, Bessy, additional, Ribas, Laia, additional, Arranz, Javier, additional, Fernandez, Susana, additional, Iulita, Maria Florencia, additional, Barroeta, Isabel, additional, Blesa, Rafael, additional, Alcolea, Daniel, additional, Lleó, Alberto, additional, and Fortea, Juan, additional

Published
2022
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41. Changes of basal forebrain volume along the Alzheimer's disease continuum in Down syndrome.

Author

Aranha, Mateus Rozalem, Iulita, Maria Florencia, Montal, Victor, Pegueroles, Jordi, Bejanin, Alexandre, Grothe, Michel J., Carmona‐Iragui, Maria, Videla, Laura, Benejam, Bessy, Valldeneu, Sílvia, Barroeta, Isabel, Altuna, Miren, Fernandez, Susana, Ribas, Laia, Padilla, Concepcion, Alcolea, Daniel, González‐Ortiz, Sofía, Bargallo, Núria, Busciglio, Jorge A, and Cuello, A. Claudio

Abstract

Background: Atrophy of basal forebrain (BF) cholinergic neurons is an early event in Alzheimer's disease (AD) and is associated with cognitive impairment. Down syndrome (DS) is now recognized as a genetically determined form of AD. Therefore, people with DS represent a priority population to study biomarkers of AD pathology and neurodegeneration. Degeneration of BF neurons occurs both in sporadic AD and in DS brains with advanced AD pathology. However, the dynamics of BF atrophy and its changes with age and AT(N) biomarkers have not been studied in DS. Method: We included 246 adults with DS (mean age 43.2 ±11.0 years; 43% female). Volumes of antero‐medial and posterior areas of the BF (amBF and pBF, respectively) were extracted from T1‐weighted 3T MR images using voxel‐based morphometry in SPM12 in combination with a stereotactic atlas of BF functional subdivisions (Figure 1). Differences in amBF and pBF volume in each AD clinical stage (Asymptomatic, Prodromal and Demented) were assessed with Kruskall‐Wallis and pairwise Wilcoxon tests. The relationship of BF volumes with age and AT(N) biomarkers in the cerebrospinal fluid (CSF) (amyloid‐β 42/40 ratio [aβ ratio], phosphorylated Tau 181 [pTau], total Tau [tTau] and neurofilament light [NFL]) was assessed in a subset of subjects (n = 161 [aβ ratio, pTau and tTau] and n = 95 [NFL]) with locally estimated scatterplot smoothing (LOESS) and linear regression in R, respectively. Result: Volumes of amBF and pBF decreased significantly with age (Figure 2), with a steeper decline during the fifth decade of life. BF volumes also declined with AD clinical stage (Figure 3), and had significant correlations with CSF aβ ratio (p<0.001 r2 = 0.22), pTau (p<0.001 r2 = 0.20), tTau (p<0.001 r2 = 0.20) and NFL (p<0.001 r2 = 0.33) (Figure 4). Conclusion: In DS, BF volume decreases with age, AT(N) biomarkers and along the cognitive stages of the AD continuum. [ABSTRACT FROM AUTHOR]

Published
2023
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42. DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients

Author

Moreau, Manon, primary, Carmona-Iragui, Maria, additional, Altuna, Miren, additional, Dalzon, Lorraine, additional, Barroeta, Isabel, additional, Vilaire, Marie, additional, Durand, Sophie, additional, Fortea, Juan, additional, Rebillat, Anne-Sophie, additional, and Janel, Nathalie, additional

Published
2022
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43. Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome.

Author

Iulita, M. Florencia, Bejanin, Alexandre, Vilaplana, Eduard, Carmona-Iragui, Maria, Benejam, Bessy, Videla, Laura, Barroeta, Isabel, Fernández, Susana, Altuna, Miren, Pegueroles, Jordi, Montal, Victor, Valldeneu, Silvia, Giménez, Sandra, González-Ortiz, Sofía, Torres, Soraya, El Bennadi, Shaimaa El Bounasri, Padilla, Concepcion, Aranha, Mateus Rozalem, Estellés, Teresa, and Illán-Gala, Ignacio

Published
2023
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45. Additional file 2 of Neural correlates of episodic memory in adults with Down syndrome and Alzheimer’s disease

Author

Benejam, Bessy, Aranha, Mateus Rozalem, Videla, Laura, Padilla, Concepción, Valldeneu, Silvia, Fernández, Susana, Altuna, Miren, Carmona-Iragui, Maria, Barroeta, Isabel, Iulita, Maria Florencia, Montal, Víctor, Pegueroles, Jordi, Bejanin, Alexandre, Giménez, Sandra, González-Ortiz, Sofía, Videla, Sebastián, Bartrés-Faz, David, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, and Fortea, Juan

Abstract

Additional file 2. MRI acquisition protocols.

Published
2022
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46. Additional file 1 of Neural correlates of episodic memory in adults with Down syndrome and Alzheimer’s disease

Author

Benejam, Bessy, Aranha, Mateus Rozalem, Videla, Laura, Padilla, Concepción, Valldeneu, Silvia, Fernández, Susana, Altuna, Miren, Carmona-Iragui, Maria, Barroeta, Isabel, Iulita, Maria Florencia, Montal, Víctor, Pegueroles, Jordi, Bejanin, Alexandre, Giménez, Sandra, González-Ortiz, Sofía, Videla, Sebastián, Bartrés-Faz, David, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, and Fortea, Juan

Abstract

Additional file 1: Supplementary Figure 1. Study flow chart. Description of data: flow chart of included and excluded subjects. Footnote: ID, intellectual disability; mCRT, modified Cued Recall Test; MRI, magnetic resonance imaging; OCD, obsessive compulsive disorder.

Published
2022
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48. Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels in Down Syndrome and Sporadic Alzheimer´S Disease: A Cross-Sectional Study

Author

Montoliu-Gaya, Laia, primary, Alcolea, Daniel, additional, Ashton, Nicholas J., additional, Pegueroles, Jordi, additional, Levin, Johannes, additional, Carmona Iragui, Maria, additional, Lantero-Rodriguez, Juan, additional, Karikari, Thomas K., additional, Barroeta, Isabel, additional, Kac, Przemyslaw Radoslaw, additional, Videla, Laura, additional, Gonzalez-Ortiz, Fernando, additional, Benejam, Bessy, additional, Nübling, Georg, additional, Benedet, Andrea L., additional, Blesa, Rafael, additional, Lleó, Alberto, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, and Fortea, Juan, additional

Published
2022
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49. A multimodal study on the effect of sex on Alzheimer's disease clinical and biomarker changes in adults with Down syndrome

Author

Iulita, M. Florencia, primary, Bejanin, Alexandre, additional, Vilaplana, Eduard, additional, Carmona‐Iragui, Maria, additional, Benejam, Bessy, additional, Videla, Laura, additional, Barroeta, Isabel, additional, Fernandez, Susana, additional, Altuna, Miren, additional, Pegueroles, Jordi, additional, Montal, Victor, additional, Valldeneu, Sílvia, additional, Giménez, Sandra, additional, González‐Ortiz, Sofía, additional, Muñoz, Laia, additional, Padilla, Concepción, additional, Aranha, Mateus Rozalem, additional, Estellés, Teresa, additional, Illán‐Gala, Ignacio, additional, Belbin, Olivia, additional, Tamayo, Natalia Valle, additional, Camacho, Valle, additional, Wilson, Liam, additional, Annus, Tiina, additional, Osorio, Ricardo, additional, Videla, Sebastián, additional, Lehmann, Sylvain, additional, Holland, Anthony J, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Alcolea, Daniel, additional, Clarimón, Jordi, additional, Zaman, Shahid, additional, Blesa, Rafael, additional, Lleó, Alberto, additional, and Fortea, Juan, additional

Published
2021
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50. Neuropsychological correlates of plasma NfL in adults with Down syndrome

Author

Carmona‐Iragui, Maria, primary, Videla, Laura, additional, Benejam, Bessy, additional, Valldeneu, Sílvia, additional, Barroeta, Isabel, additional, Altuna, Miren, additional, Fernandez, Susana, additional, Garzón, Diana, additional, Padilla, Concepción, additional, Iulita, M. Florencia, additional, Bejanin, Alexandre, additional, Alcolea, Daniel, additional, Blesa, Rafael, additional, Lleó, Alberto, additional, and Fortea, Juan, additional

Published
2021
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