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15 results on '"Carlus, S. Justin"'

3. Genotype-Phenotype Study of the Middle Gangetic Plain in India Shows Association of rs2470102 with Skin Pigmentation

Author

Mishra, Anshuman, Nizammuddin, Sheikh, Mallick, Chandana Basu, Singh, Sakshi, Prakash, Satya, Siddiqui, Niyamat Ali, Rai, Niraj, Carlus, S. Justin, Sudhakar, Digumarthi V.S., Tripathi, Vishnu P., Möls, Märt, Kim-Howard, Xana, Dewangan, Hemlata, Mishra, Abhishek, Reddy, Alla G., Roy, Biswajit, Pandey, Krishna, Chaubey, Gyaneshwer, Das, Pradeep, Nath, Swapan K., Singh, Lalji, and Thangaraj, Kumarasamy

Published
2017
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4. The peopling of Lakshadweep Archipelago

Author

Mustak, Mohammed S., Rai, Niraj, Naveen, Mohan Rao, Prakash, Satya, Carlus, S. Justin, Pasupuleti, Nagarjuna, Srivastava, Anshika, Singh, Prajjval Pratap, Babu, Idrees, Dubey, Pavan Kumar, Chaubey, Gyaneshwer, and Thangaraj, Kumarasamy

Published
2019
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9. The Polymorphism at the microRNA-155 Binding Site in the AGTR1 Gene is not Significantly Associated with Rheumatic Heart Disease in Saudi Arabia Population

Author

Carlus, S. Justin, Carlus, Fiona Hannah, Al-Harbi, Mazen Khalid, Al-Mazroea, Abdulhadi H., Al-Harbi, Khalid M., and Abdallah, Atiyeh M.

Abstract

Background: Rheumatic Heart Disease (RHD) remains a major cause of cardiovascular diseases and the most devastating effects are shown on children and young adults. RHD is caused due to the interaction between microbial, environmental, immunologic, and genetic factors. The Renin- Angiotensin Aldosterone System (RAAS) has been strongly implicated as the susceptibility pathway in the pathogenesis of the cardiovascular disease. Objective: The present study investigated the modulating effect of Angiotensin II type 1 receptor (AGTR1) 1166A>C polymorphism on the RHD and its clinical features in Saudi Arabia. Methods: AGTR1 1166A>C polymorphism was genotyped in 96 echocardiographically confirmed RHD patients and 142 ethnically matched controls by the TaqMan allelic discrimination method. Results: Genotype distribution of the AGTR1 1166A>C polymorphism was not significantly different between RHD and control groups. Furthermore, AGTR1 1166A>C genotypes are not associated with the clinical features of RHD. These data support that there was no evidence for an association between AGTR1 1166A>C polymorphism and RHD in Saudi Arabia. Conclusion: To the best of our knowledge, this is the first study that has investigated the possible association between AGTR1 1166A>C polymorphism and susceptibility to RHD and its clinical features. Even though the AGTR1 gene, 1166A>C (rs5186), was reported to be associated with hypertension, left ventricular hypertrophy and coronary heart disease. The present study did not find any association between AGTR1 1166A>C polymorphism and RHD in Saudi Arabia. Further studies are needed to confirm our findings.

Published
2020
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10. Is MTHFR 677 C>T Polymorphism Clinically Important in Polycystic Ovarian Syndrome (PCOS)? A Case-Control Study, Meta-Analysis and Trial Sequential Analysis

Author

Carlus, S. Justin, primary, Sarkar, Saumya, additional, Bansal, Sandeep Kumar, additional, Singh, Vertika, additional, Singh, Kiran, additional, Jha, Rajesh Kumar, additional, Sadasivam, Nirmala, additional, Sadasivam, Sri Revathy, additional, Gireesha, P. S., additional, Thangaraj, Kumarasamy, additional, and Rajender, Singh, additional

Published
2016
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13. Mitochondrial DNA variations associated with recurrent pregnancy loss among Indian women

Author

Vanniarajan, Ayyasamy, primary, Govindaraj, Periyasamy, additional, Carlus, S. Justin, additional, Aruna, Meka, additional, Aruna, P., additional, Kumar, Ajay, additional, Jayakar, Richard Issac, additional, Lionel, Anath C., additional, Gupta, Sandeep, additional, Rao, Lakshmi, additional, Gupta, Nalini J., additional, Chakravarthy, Baidyanath, additional, Deenadayal, Mamatha, additional, Selvaraj, Kamala, additional, Andal, Sadaranga, additional, Reddy, B. Mohan, additional, Singh, Lalji, additional, and Thangaraj, Kumarasamy, additional

Published
2011
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14. CAG repeat variation in the mtDNA polymerase γ is not associated with oligoasthenozoospermia

Author

Rani, Deepa Selvi, primary, Carlus, S. Justin, additional, Poongothai, J., additional, Jyothi, Amara, additional, Pavani, Kadupa, additional, Gupta, Nalini J., additional, Reddy, Alla G., additional, Rajan, M. Mamtha, additional, Rao, Kamini, additional, Chakravarty, Baidyanath, additional, Singh, Lalji, additional, and Thangaraj, Kumarasamy, additional

Published
2008
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15. CAG repeat variation in the mtDNA polymerase γ is not associated with oligoasthenozoospermia.

Author

Rani, Deepa Selvi, Carlus, S. Justin, Poongothai, J., Jyothi, Amara, Pavani, Kadupa, Gupta, Nalini J., Reddy, Alla G., Rajan, M. Mamtha, Rao, Kamini, Chakravarty, Baidyanath, Singh, Lalji, and Thangaraj, Kumarasamy

Subjects
*MALE infertility, *MITOCHONDRIA, *TRINUCLEOTIDE repeats, *DNA polymerases, *DNA replication
Abstract

Variations in the trinucleotide-CAG repeat number of the catalytic subunit of the mitochondrial DNA polymerase gamma (POLG) have been speculated to be associated with male infertility. The ten CAG repeats (10/10) were found to be the most common allele (88%), absence of which was found to be associated with male infertility. As no study on Indian population was conducted so far to support this view, we investigated the distribution of the POLG-CAG repeats in 509 oligoasthenozoospermic and 241 normozoospermic control Indian men from the same ethnic background. Our study suggested that the distribution of common allele (10/10) was almost similar in both infertile (75%) and normozoospermic (75.5%) men. Further, we had analysed the CAG repeat number in as many as 1306 Indian men belonging to different ethnic, geographical and linguistic backgrounds and found the common allele 10/10 at a frequency of 78.4%. Our study, therefore, suggests that the 10-CAG repeat is the most common allele present in Indian populations, but its absence and the occurrence of the other mutant homozygous (non 10/non 10) genotype should not be understood as being specific to infertility. It, thus, suggests that the POLG-CAG repeat variation is not associated with male infertility in Indian populations, and hence is not a useful marker for screening infertile men. [ABSTRACT FROM AUTHOR]

Published
2009
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