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2. Endothelial permeability, LDL deposition, and cardiovascular risk factors—a review

Author

Mundi, Santa, Massaro, Marika, Scoditti, Egeria, Carluccio, Maria Annunziata, van Hinsbergh, Victor WM, Iruela-Arispe, Marial Luisa, and De Caterina, Raffaele

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Atherosclerosis, Cardiovascular, Prevention, Genetics, Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Animals, Arteries, Biological Transport, Comorbidity, Endothelium, Vascular, Humans, Inflammation Mediators, Lipoproteins, LDL, Oxidative Stress, Permeability, Plaque, Atherosclerotic, Prognosis, Reactive Oxygen Species, Risk Factors, Signal Transduction, Smoking, Cardiovascular risk factors, Endothelium, Vascular permeability, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Early atherosclerosis features functional and structural changes in the endothelial barrier function that affect the traffic of molecules and solutes between the vessel lumen and the vascular wall. Such changes are mechanistically related to the development of atherosclerosis. Proatherogenic stimuli and cardiovascular risk factors, such as dyslipidaemias, diabetes, obesity, and smoking, all increase endothelial permeability sharing a common signalling denominator: an imbalance in the production/disposal of reactive oxygen species (ROS), broadly termed oxidative stress. Mostly as a consequence of the activation of enzymatic systems leading to ROS overproduction, proatherogenic factors lead to a pro-inflammatory status that translates in changes in gene expression and functional rearrangements, including changes in the transendothelial transport of molecules, leading to the deposition of low-density lipoproteins (LDL) and the subsequent infiltration of circulating leucocytes in the intima. In this review, we focus on such early changes in atherogenesis and on the concept that proatherogenic stimuli and risk factors for cardiovascular disease, by altering the endothelial barrier properties, co-ordinately trigger the accumulation of LDL in the intima and ultimately plaque formation.

Published
2018

5. Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications

Author

Giannotti, Laura, primary, Di Chiara Stanca, Benedetta, additional, Spedicato, Francesco, additional, Nitti, Paola, additional, Damiano, Fabrizio, additional, Demitri, Christian, additional, Calabriso, Nadia, additional, Carluccio, Maria Annunziata, additional, Palermo, Andrea, additional, Siculella, Luisa, additional, and Stanca, Eleonora, additional

Published
2023
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6. Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes

Author

Carpi, Sara, primary, Quarta, Stefano, additional, Doccini, Stefano, additional, Saviano, Anella, additional, Marigliano, Noemi, additional, Polini, Beatrice, additional, Massaro, Marika, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Wabitsch, Martin, additional, Santorelli, Filippo Maria, additional, Cecchini, Marco, additional, Maione, Francesco, additional, Nieri, Paola, additional, and Scoditti, Egeria, additional

Published
2023
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8. Contributors

Author

Abete, Itziar, primary, Agirre, Xabier, additional, Ahlgren, Jennie, additional, Alkorta-Aranburu, Gorka, additional, Aller, Rocío, additional, Andres-Lacueva, Cristina, additional, Antonio de Luis, Daniel, additional, Babino, Darwin, additional, Bar-El Dadon, Shimrit, additional, Bonet, Maria Luisa, additional, Bordoni, Laura, additional, Borel, Patrick, additional, Bosch, Annet M., additional, Brown, Steven, additional, Busso, Dolores, additional, Calabriso, Nadia, additional, Capurso, Antonio, additional, Capurso, Cristiano, additional, Cariello, Marica, additional, Carluccio, Maria Annunziata, additional, Casas-Agustench, Patricia, additional, Cheatham, Carol L., additional, Chirita-Emandi, Adela, additional, Chittoor, Geetha, additional, Choi, Myung-Sook, additional, Choi, Sang-Woon, additional, Cordero, Paul, additional, Corrales, Fernando J., additional, Cortés, Víctor, additional, Cross, Nicholas C.P., additional, Crujeiras, Ana B., additional, Curi, Rui, additional, De Caterina, Raffaele, additional, de Lorenzo, David, additional, Desmarchelier, Charles, additional, Dong, Olivia, additional, Estruch, Ramón, additional, Ezponda, Teresa, additional, Fenech, Michael, additional, Ferguson, Lynnette R., additional, Fischer, Karina, additional, Fontana, Luigi, additional, Friso, Simonetta, additional, Gabbianelli, Rosita, additional, Garaulet, Marat, additional, Garcia-Irigoyen, Oihane, additional, Gil, Angel, additional, Gómez-Abellán, Purificación, additional, Görman, Ulf, additional, Harris, William S., additional, Hernandez-Vazquez, Alain de J., additional, Hugenholtz, Paul, additional, Hyde, Lara K., additional, Ibáñez, Clara, additional, Izaola, Olatz, additional, Jones, Peter J.H., additional, Kirwan, Richard, additional, Kohlmeier, Martin, additional, Krupenko, Natalia I., additional, Kwon, Eun-Young, additional, Lamming, Dudley W., additional, Lamuela-Raventos, Rosa M., additional, Langin, Dominique, additional, Langley-Evans, Simon, additional, Lira do Amaral, Cátia, additional, Lopez-Minguez, Jesus, additional, Madonna, Rosalinda, additional, Mansego, Maria L., additional, Marotz, Clarisse, additional, Martinez, J. Alfredo, additional, Massaro, Marika, additional, McRitchie, Susan, additional, Mesmar, Bayan, additional, Milagro, Fermín I., additional, Moreno-Aliaga, María J., additional, Moreno-Indias, Isabel, additional, Moschetta, Antonio, additional, Navas-Carretero, Santiago, additional, Niculescu, Mihai, additional, Nordström, Karin, additional, Novo, Francisco J., additional, Oben, Jude A., additional, Odriozola, Leticia, additional, Ordovas, Jose M., additional, Palou, Andreu, additional, Parslow, Virginia R., additional, Pathmasiri, Wimal, additional, Pérez-Castrillón, José Luis, additional, Pérusse, Louis, additional, Piccinin, Elena, additional, Plaza-Diaz, Julio, additional, Prósper, Felipe, additional, Qi, Lu, additional, Ralston, Jessica C., additional, Ramírez de Molina, Ana, additional, Rasti, George, additional, Reifen, Ram, additional, Renda, Giulia, additional, Riancho, José A., additional, Riancho del Moral, José Antonio, additional, Rivadeneira, Fernando, additional, Roche, Helen M., additional, Ruiz-Mambrilla, Marta, additional, Ruiz-Ojeda, Francisco Javier, additional, Salas-Pérez, Francisca, additional, San-Cristobal, Rodrigo, additional, Santander, Nicolás, additional, Santos, José L., additional, Saupe, Jörg, additional, Scoditti, Egeria, additional, Serhan, Charles N., additional, Simonet, Nicolas G., additional, Simopoulos, Artemis P., additional, Steinle, Nanette, additional, Sumner, Susan C.J., additional, Tinahones, Francisco J., additional, Vaquero, Alejandro, additional, Vazquez-Vidal, Itzel, additional, Velazquez-Arellano, Antonio, additional, Viguerie, Nathalie, additional, Vinciguerra, Manlio, additional, Visioli, Francesco, additional, Vizmanos, José L., additional, von Lintig, Johannes, additional, Voruganti, Venkata Saroja, additional, Wanders, Ronald J.A., additional, Wang, Tiange, additional, Wiltshire, Tim, additional, Yu, Deyang, additional, Zarrinpar, Amir, additional, Zeisel, Steven H., additional, and Zulet, Maria Angeles, additional

Published
2020
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10. Association between Mediterranean lifestyle and perception of well-being and distress in a sample population of university Italian students

Author

Quarta, Stefano, primary, Siculella, Luisa, additional, Levante, Annalisa, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Scoditti, Egeria, additional, Damiano, Fabrizio, additional, Lecciso, Flavia, additional, Pinto, Paula, additional, García-Conesa, María-Teresa, additional, Pollice, Fabio, additional, and Massaro, Marika, additional

Published
2023
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11. Hydroxyapatite–Silicon Scaffold Promotes Osteogenic Differentiation of CGF Primary Cells

Author

Giannotti, Laura, primary, Di Chiara Stanca, Benedetta, additional, Nitti, Paola, additional, Spedicato, Francesco, additional, Damiano, Fabrizio, additional, Demitri, Christian, additional, Calabriso, Nadia, additional, Carluccio, Maria Annunziata, additional, Palermo, Andrea, additional, Ferrante, Franco, additional, Siculella, Luisa, additional, and Stanca, Eleonora, additional

Published
2023
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15. Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation

Author

Palermo, Andrea, primary, Giannotti, Laura, additional, Di Chiara Stanca, Benedetta, additional, Ferrante, Franco, additional, Gnoni, Antonio, additional, Nitti, Paola, additional, Calabriso, Nadia, additional, Demitri, Christian, additional, Damiano, Fabrizio, additional, Batani, Tiziano, additional, Lungherini, Massimo, additional, Carluccio, Maria Annunziata, additional, Rapone, Biagio, additional, Qorri, Erda, additional, Scarano, Antonio, additional, Siculella, Luisa, additional, Stanca, Eleonora, additional, and Rochira, Alessio, additional

Published
2022
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16. Association between Mediterranean lifestyle and perception of well-being and distress in a sample population of university Italian students

Author

Quarta, Stefano, Siculella, Luisa, Levante, Annalisa, Carluccio, Maria Annunziata, Calabriso, Nadia, Scoditti, Egeria, Damiano, Fabrizio, Lecciso, Flavia, Pinto, Paula, García-Conesa, María-Teresa, Pollice, Fabio, and Massaro, Marika

Abstract

We investigated the extent to which adherence to the Mediterranean diet (MD) in combination with Mediterranean lifestyle factors influenced students’ perceptions of subjective well-being (SWB) and distress. 939 undergraduates completed a survey to assess sociodemographic and lifestyle characteristics, including adherence to the MD, depression, anxiety, stress, and SWB. Data were analysed with correlation, logistic, and multiple linear regression models. Higher adherence to MD correlated with better SWB. Fruit, red meat, sweet and caffeinated beverages contributed significantly. However, it was the combination of adherence to MD with other factors, including quality of social relationships, income, smoking, sleep, and physical activity that better predicted SWB. Our results confirm the positive influence of MD on SWB. However, they also suggest the need to consider perceptions of well-being by a more holistic approach that considers physical and social factors simultaneously to improve the development of more effective educational and motivational programmes.

Published
2023
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17. Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast®, a Combination of Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis

Author

Quarta, Stefano, primary, Santarpino, Giuseppe, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Scoditti, Egeria, additional, Siculella, Luisa, additional, Damiano, Fabrizio, additional, Maffia, Michele, additional, Verri, Tiziano, additional, De Caterina, Raffaele, additional, and Massaro, Marika, additional

Published
2022
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21. Assessment of Subjective Well-Being in a Cohort of University Students and Staff Members: Association with Physical Activity and Outdoor Leisure Time during the COVID-19 Pandemic

Author

Quarta, Stefano, primary, Levante, Annalisa, additional, García-Conesa, María-Teresa, additional, Lecciso, Flavia, additional, Scoditti, Egeria, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Damiano, Fabrizio, additional, Santarpino, Giuseppe, additional, Verri, Tiziano, additional, Pinto, Paula, additional, Siculella, Luisa, additional, and Massaro, Marika, additional

Published
2022
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24. Coffee Bioactive N-Methylpyridinium Attenuates Tumor Necrosis Factor (TNF)-α-Mediated Insulin Resistance and Inflammation in Human Adipocytes

Author

Quarta, Stefano, primary, Scoditti, Egeria, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Santarpino, Giuseppe, additional, Damiano, Fabrizio, additional, Siculella, Luisa, additional, Wabitsch, Martin, additional, Verri, Tiziano, additional, Favari, Claudia, additional, Del Rio, Daniele, additional, Mena, Pedro, additional, De Caterina, Raffaele, additional, and Massaro, Marika, additional

Published
2021
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26. Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast ® , a Combination of Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis

Author

Quarta, Stefano, Santarpino, Giuseppe, Carluccio, Maria Annunziata, Calabriso, Nadia, Scoditti, Egeria, Siculella, Luisa, Damiano, Fabrizio, Maffia, Michele, Verri, Tiziano, De Caterina, Raffaele, and Massaro, Marika

Subjects
TURMERIC, PLANT extracts, BROMELIN, BOSWELLIA, TRANSFORMING growth factors, CARTILAGE cells, OSTEOARTHRITIS, ENDOTHELIAL cells
Abstract

Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium, angiogenesis, cartilage degradation, and osteophyte formation. Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum) are plants which extracts, together to Bromelain and Escin (Aesculus hippocastanum) are traditionally used in OA. However, their mechanistic role remains unclear. We aimed to investigate whether these bioactives alone or in combination (as in Flonat Fast®) can suppress TNF-α-induced inflammation, angiogenesis, and osteophyte formation using two cell models involved in OA: endothelial cells and monocytes. Each plant extract was evaluated for its polyphenol content, antioxidant activity, and toxicity. In endothelial cells and monocytes, expression of genes involved in OA was assessed, functional assays for inflammation and angiogenesis were performed, and impairment of reactive oxygen species production (ROS) was evaluated. Exposure of cells to the bioactives alone and in combination before cytokine stimulation resulted in differential counterregulation of several gene and protein expressions, including those for cyclooxygenases-2, metalloproteinase-9, transforming growth factor β1, and bone morphogenic protein-2. We demonstrated that these bioactives modulated monocyte adhesion to endothelial cells as well as cell migration and endothelial angiogenesis. Consistent with radical scavenging activity in the cell-free system, the bioactives curbed TNF-α-stimulated intracellular ROS production. We confirmed the potential anti-inflammatory and antiangiogenic effects of the combination of Harpagophytum procumbens, Boswellia, Curcuma, Bromelain, and Escin and provided new mechanistic evidence for their use in OA. However, further clinical studies are needed to evaluate the true clinical utility of these bioactives as supportive, preventive, and therapeutic agents. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Contributors

Author

Agudo, Antonio, primary, Alarcón, Marisa, additional, Aldasoro, Juan José, additional, Antonopoulou, Smaragdi, additional, Arnoni, Yardena, additional, Arranz, Sara, additional, Atteia, Hebatallah Husseini, additional, Azzini, Elena, additional, Badimon, Lina, additional, Bastida, Sara, additional, Beccari, Giovanni, additional, Berry, Elliot M., additional, Biandolino, Francesca, additional, Bonaccio, Marialaura, additional, Bonachela, Santiago, additional, Bonanni, Americo, additional, Bosco, Gerardo, additional, Buckland, Genevieve, additional, Calabriso, Nadia, additional, Caliskan, Oguzhan, additional, Carluccio, Maria Annunziata, additional, Casas, J. Jesús, additional, Casas, Rosa, additional, Castro-Quezada, Itandehui, additional, Chiva-Blanch, Gemma, additional, Conti, Gea Oliveri, additional, Copat, Chiara, additional, Couture, Patrick, additional, Covarelli, Lorenzo, additional, De Caterina, Raffaele, additional, De Feo, Vincenzo, additional, de Gaetano, Giovanni, additional, de Lorgeril, Michel, additional, De Martino, Laura, additional, Demetriou, Christiana A., additional, Detopoulou, Paraskevi, additional, Diamantopoulos, Emmanuel J., additional, Djuric, Zora, additional, Donati, Maria Benedetta, additional, Doreste-Alonso, Jorge, additional, El Rhazi, Karima, additional, El-Swefy, Sahar Elsayed, additional, Rodilla, Manuel Espárrago, additional, Estruch, Ramon, additional, Fallico, Roberto, additional, Farajian, Paul, additional, Fenoy, Encarnación, additional, Fernandez, J.M., additional, Fernandez, Maria Luz, additional, Fernández-Real, José Manuel, additional, Ferrante, Margherita, additional, Fragopoulou, Elizabeth, additional, Fuentes-Jimenez, F., additional, Gaforio, José J., additional, Garaulet, Marta, additional, Garcia-Larsen, Vanessa, additional, Gardener, Hannah, additional, Gesteiro, Eva, additional, Goldstein, Mark R., additional, González, Carlos A., additional, Gouveri, Evanthia, additional, Granados, Sergio, additional, Grimaldi, Keith, additional, Hadjisavvas, Andreas, additional, Henríquez-Sánchez, Patricia, additional, Hernández, Joaquín, additional, Iacoviello, Licia, additional, Iriti, Marcello, additional, Karageorgou, Dimitra, additional, Kontou, Niki, additional, Kyriacou, Kyriacos, additional, La Torre, Giuseppe, additional, Lairon, Denis, additional, Lamarche, Benoît, additional, Lee, Jaime, additional, Loizidou, Maria A., additional, López-Biedma, Alicia, additional, Macpherson, Helen, additional, Maiani, Giuseppe, additional, Mancini, Emilia, additional, Martin, Colin R., additional, Martínez-González, Miguel Ángel, additional, Mascitelli, Luca, additional, Massaro, Marika, additional, Medina, F. Xavier, additional, Mendieta, Guiomar, additional, Mesías, Marta, additional, Micha, Renata, additional, Moreno-Navarrete, José María, additional, Moyano, Francisco J., additional, Navarro, M. Pilar, additional, Nazzaro, Filomena, additional, Nejjari, Chakib, additional, Nilsson, Lena Maria, additional, Nomikos, Tzortzis, additional, Oliviero, Francesca, additional, Erdogan Orhan, Ilkay, additional, Paoli, Antonio, additional, Papandreou, Christopher, additional, Pase, Matthew, additional, Pellegrino, Mariangela, additional, Pipingas, Andrew, additional, Potenza, Concetta, additional, Prato, Ermelinda, additional, Preedy, Victor R., additional, Pulido-Moran, Mario, additional, Punzi, Leonardo, additional, Quiles, José L., additional, Ramírez-Tortose, Ma del Carmen, additional, Richard, Caroline, additional, Rodríguez Bernal, Beatriz, additional, Román-Viñas, Blanca, additional, Ros, Emilio, additional, Rosado-Alvarez, D., additional, Ríos, José-Luis, additional, Ruano, Cristina, additional, Sahingoz, Semra Akar, additional, Salen, Patricia, additional, Sánchez Benito, José L., additional, Soriano, Eva Sánchez, additional, Sánchez-Muniz, Francisco J., additional, Sánchez-Quesada, Cristina, additional, Sánchez-Villegas, Almudena, additional, Saulle, Rosella, additional, Scholey, Andrew, additional, Sciacca, Salvatore, additional, Scoditti, Egeria, additional, Seiquer, Isabel, additional, Semyonov, Leda, additional, Serra-Majem, Lluís, additional, Sewell, Dean A., additional, Sfriso, Paolo, additional, Sheikh, Aziz, additional, Skroza, Nevena, additional, Spinella, Paolo, additional, Tosi, Laura, additional, Tumen, Ibrahim, additional, Valderas-Martinez, Palmira, additional, Varoni, Elena M., additional, Vilahur, Gemma, additional, Villalon, Lorena, additional, Villarroya, Gemma Xifra, additional, Vineis, Paolo, additional, Warleta, Fernando, additional, Wright, Clinton B., additional, Zacharski, Leo R., additional, Zampelas, Antonis, additional, and Zuber, Sara, additional

Published
2015
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28. Mediterranean Diet Polyphenols

Author

Carluccio, Maria Annunziata, primary, Calabriso, Nadia, additional, Scoditti, Egeria, additional, Massaro, Marika, additional, and De Caterina, Raffaele, additional

Published
2015
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29. Analysis of CGF Biomolecules, Structure and Cell Population: Characterization of the Stemness Features of CGF Cells and Osteogenic Potential

Author

Stanca, Eleonora, primary, Calabriso, Nadia, additional, Giannotti, Laura, additional, Nitti, Paola, additional, Damiano, Fabrizio, additional, Stanca, Benedetta Di Chiara, additional, Carluccio, Maria Annunziata, additional, De Benedetto, Giuseppe Egidio, additional, Demitri, Christian, additional, Palermo, Andrea, additional, Ferrante, Franco, additional, Siculella, Luisa, additional, and Rochira, Alessio, additional

Published
2021
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31. List of Contributors

Author

Aguiar, Odair, primary, Alkholy, Sarah Omar, additional, Allgrove, Judith, additional, Alqahtani, Samiah Naji, additional, Amini, Anna, additional, de Mello Andrade, Juliana Maria, additional, Andres-Lacueva, Cristina, additional, Aquilato, Andrea, additional, Arora, Rajesh, additional, Arranz, Sara, additional, Ashida, Hitoshi, additional, Avena, Paola, additional, Badole, Sachin L., additional, Baer-Dubowska, Wanda, additional, Bahrim, Gabriela, additional, Baliga, Manjeshwar Shrinath, additional, Barnes, Stephen, additional, Batista, Maria T., additional, Berhanu, Workalemahu Mikre, additional, Bhatia, Alka, additional, Bodhankar, Subhash L., additional, Bodnar, Lubomir, additional, Bolca, Selin, additional, Boto-Ordoñez, Maria, additional, Brizuela, Leyre, additional, Calhau, Conceição, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pozo, Catalina, additional, Caruso, Anna, additional, Casaburi, Ivan, additional, Castro, Gerardo D., additional, Castro, José A., additional, Celep, Gulcin Sagdicoglu, additional, Chacko, Amala, additional, Chaudhari, Swapnil M., additional, Chen, Chung-Hwan, additional, Chen, Lixia, additional, Chiva-Blanch, Gemma, additional, Christensen, Kathrine Bisgaard, additional, Christensen, Lars Porskjær, additional, Chyu, Ming-Chien, additional, Cordova, Felina M., additional, Corona, Giulia, additional, Costa, G., additional, Cress, Brady F., additional, Crozier, Stephen J., additional, Cruz, M.T., additional, Cuvillier, Olivier, additional, Čvorović, Jovana, additional, Cyr, Lisa Danielle, additional, Czank, Charles, additional, D’Archivio, Massimo, additional, Davison, Glen, additional, De Caterina, Raffaele, additional, Deng, Guifang, additional, Devkar, Ranjitsinh V., additional, Doo, Taisha, additional, Doonan, Barbara, additional, Emami, Seyed Ahmad, additional, Estruch, Ramón, additional, Virgili, Fabio, additional, Falk, Michael, additional, Faria, Ana, additional, Farina, Grazia, additional, Fasolo, Daniel, additional, Fayad, Raja, additional, Ferreira, Maria Pontes, additional, Ferri, Claudio, additional, Forester, Sarah C., additional, Fornasaro, Stefano, additional, Cimino, Francesco, additional, Francis, Atul, additional, Francisco, V., additional, Fukuda, Itsuko, additional, Garcia-Aloy, Mar, additional, García-Mediavilla, María Victoria, additional, Gendron, Fidji, additional, Ghantasala, S., additional, Gil-Becerra, David, additional, Giovannini, Claudio, additional, Givigliano, Francesco, additional, Goldstein, Mark R., additional, Goel, Ajay, additional, Gollücke, Andréa Pittelli Boiago, additional, González-Gallego, Javier, additional, Govindaraghavan, Suresh, additional, Grassi, Davide, additional, Gunawardena, Dhanushka, additional, Guo, Honghui, additional, Habauzit, Véronique, additional, Haegeman, Guy, additional, He, Xiran, additional, Hegde, Mahabaleshwar V., additional, Heyninck, Karen, additional, Hsieh, Tze-chen, additional, Hurst, W. Jeffrey, additional, Iemma, Francesca, additional, Igoe, Ann, additional, Iglesias, Jacobo, additional, Ikeda, Ikuo, additional, Jadeja, Ravirajsinh N., additional, Jaffe, Russell, additional, Janda, Elzbieta, additional, Janel, Nathalie, additional, Jangam, Ganesh B., additional, Jayachander, Dipika, additional, Jiang, Fan, additional, Jirillo, Emilio, additional, Joo, Eun Ji, additional, Joseph, Nadhini, additional, Aguiar, Odair, additional, Juturu, Vijaya, additional, Kalekhan, Faizan, additional, Kamath, Krithika, additional, Karana, Rita, additional, Kaur, Kamaljeet, additional, Keating, Elisa, additional, Kennedy, David O., additional, Kerr, Jason, additional, Khaled, Mohd, additional, Khoo, Christina, additional, Khymenets, Olha, additional, Kim, Jiyoung, additional, Kobayashi, Makoto, additional, Kobori, Masuko, additional, Kochikuzhyil, Benson Mathai, additional, Koffas, Mattheos A.G., additional, Korniluk, Jan, additional, Kumar, Ashish, additional, Kumar, G., additional, Kumar, Yashwant, additional, Kumazawa, Yosho, additional, Kurien, Biji T., additional, Kwun, In-Sook, additional, Lambert, Joshua D., additional, Lamuela-Raventos, Rosa Maria, additional, Latheef, Latheesh, additional, Lee, Hyong Joo, additional, Lee, Ki Won, additional, Li, Huabin, additional, Li, Sha, additional, Llorach, Rafael, additional, Lopez, Victoria, additional, Maciel, María E., additional, Magrone, Thea, additional, Mani, Jayashree, additional, Marotta, Francesco, additional, Marquardt, Kristen Conrad, additional, Martel, Fátima, additional, Martínez, Verónica, additional, Maru, Girish B., additional, Mascitelli, Luca, additional, Masella, Roberta, additional, Maskarinec, Gertraud, additional, Massaro, Marika, additional, Masunov, Artëm E., additional, Mathew, Geetha, additional, Medina, Isabel, additional, Medina-Remón, Alexander, additional, Menaa, Abder, additional, Menaa, Bouzid, additional, Menaa, Farid, additional, Miglio, C., additional, Milenkovic, Dragan, additional, Mitjans, Montserrat, additional, Miura, Tomisato, additional, Mo, Huanbiao, additional, Mollace, Vincenzo, additional, Morand, Christine, additional, Moribito, G., additional, Mudgal, Piya Paul, additional, Münch, Gerald, additional, Murakami, Akira, additional, Nagasako-Akazome, Yoko, additional, Nayak, Yogendra, additional, Neves, B.M., additional, Noll, Christophe, additional, Nowak, Renata, additional, Nowacka, Natalia, additional, Odendaal, Antoinette Y., additional, Olech, Marta, additional, Ong, Khang Wei, additional, Osakabe, Naomi, additional, Paluszczak, Jarosław, additional, Parisi, Ortensia Ilaria, additional, Passamonti, Sabina, additional, Patil, Kalyani Y., additional, Pazos, Manuel, additional, Peluso, I., additional, Petry, Nicolai, additional, Pezzi, Vincenzo, additional, Piantanida, Marta, additional, Picci, Nevio, additional, Pimple, Bhushan P., additional, Pinto, John Thomas, additional, Pires, Vanessa Cardoso, additional, Prasain, Jeevan K., additional, Pravettoni, Valerio, additional, Primavesi, Laura, additional, Puoci, Francesco, additional, Quintans, Leandro N., additional, Rabassa, Montse, additional, Rai, Prajwith, additional, Rajeev, Antappa Govindaraju, additional, Rao, Suresh, additional, Rapeanu, Gabriela, additional, Rastmanesh, Reza, additional, Ravi, Rithin, additional, Restuccia, Donatella, additional, Ribeiro, Daniel Araki, additional, Rodrigo, Ramón, additional, Rotches-Ribalta, Maria, additional, Rouhani, Mae Nicole, additional, Saldanha, Elroy, additional, Saija, Antonella, additional, Sánchez-Campos, Sonia, additional, Saxena, Arpit, additional, Scazzocchio, Beatrice, additional, Schauss, Alexander G., additional, Scoditti, Egeria, additional, Scofield, R. Hal, additional, Serafini, Mauro, additional, Sharma, Rakesh, additional, Shen, Chwan-Li, additional, Shende, Pankaj S., additional, Shetty, Vaishaka, additional, Shivashankara, Arnadi Ramachandrayya, additional, Shoji, Toshihiko, additional, Simon, Paul, additional, Sinicropi, Maria Stefania, additional, Smith, Brenda J, additional, Sony, Dargi, additional, Speciale, Antonio, additional, Spencer, Jeremy P.E., additional, Stalmach, Angélique, additional, Stanciuc, Nicoleta, additional, Stover, Mitchel G, additional, Synowiec, Agnieszka, additional, Szarlej-Wcislo, Katarzyna, additional, Tajpara, P., additional, Tan, Benny Kwong Huat, additional, Tao, Ling, additional, Tayarani-Najaran, Nilufar, additional, Tayarani-Najaran, Zahra, additional, Thilakchand, Karadka Ramdas, additional, Tomás-Barberán, Francisco A., additional, Tomás-Navarro, María, additional, Tramer, Federica, additional, Tresserra-Rimbau, Anna, additional, Tréton, Jacques, additional, Tulipani, Sara, additional, Tuñón, María J., additional, Unnikrishnan, Mazhuvancherry K., additional, Urpi-Sarda, Mireia, additional, Valderas-Martínez, Palmira, additional, Vallejo, Fernando, additional, Vauzour, David, additional, Vázquez-Fresno, Rosa, additional, Venkatesh, Ponemone, additional, Veerapur, Veeresh, additional, Vinardell, M. Pilar, additional, Walker, Ross, additional, Watson, Ronald R., additional, Wcislo, Gabriel, additional, Wightman, Emma L., additional, Wilkins, John, additional, Wu, Erxi, additional, Wu, Joseph M, additional, Wu, Shan, additional, Xia, Enqin, additional, Xia, Min, additional, Yajima, Hiroaki, additional, Zanwar, Anand A., additional, and Ziberna, Lovro, additional

Published
2014
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33. Angiogenic Properties of Concentrated Growth Factors (CGFs): The Role of Soluble Factors and Cellular Components

Author

Calabriso, Nadia, primary, Stanca, Eleonora, additional, Rochira, Alessio, additional, Damiano, Fabrizio, additional, Giannotti, Laura, additional, Di Chiara Stanca, Benedetta, additional, Massaro, Marika, additional, Scoditti, Egeria, additional, Demitri, Christian, additional, Nitti, Paola, additional, Palermo, Andrea, additional, Siculella, Luisa, additional, and Carluccio, Maria Annunziata, additional

Published
2021
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34. Homocysteine induces VCAM-1 gene expression through NF-[kappa]B and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants

Author

Carluccio, Maria Annunziata, Ancora, Maria Assunta, Massaro, Marika, Carluccio, Marisa, Scoditti, Egeria, Distante, Alessandro, Storelli, Carlo, and De Caterina, Raffaele

Subjects
Hyperhomocysteinemia -- Research, Blood circulation disorders -- Risk factors, Gene expression -- Research, DNA binding proteins -- Research, Polyphenols -- Research, Biological sciences
Abstract

Hyperhomocysteinemia is a recognized risk factor for vascular disease, but pathogenetic mechanisms involved in its vascular actions are largely unknown. Because VCAM-1 expression is crucial in monocyte adhesion and early atherogenesis, we evaluated the NF-[kappa]B-related induction of VCAM-1 by homocysteine (Hey) and the possible inhibitory effect of dietary polyphenolic antioxidants, such as trans-resveratrol (RSV) and hydroxytyrosol (HT), which are known inhibitors of NF-[kappa]B-mediated VCAM-1 induction. In human umbilical vein endothelial cells (HUVEC), Hey, at 100 [micro]mol/1, but not cysteine, induced VCAM-1 expression at the protein and mRNA levels, as shown by enzyme immunoassay and Northern analysis, respectively. Transfection studies with deletional VCAM-1 promoter constructs demonstrated that the two tandem NF-[kappa]B motifs in the VCAM-1 promoter are necessary for Hey-induced VCAM-1 gene expression. Hcy-induced NF-[kappa]B activation was confirmed by EMSA, as shown by the nuclear translocation of its p65 (RelA) subunit and the degradation of the inhibitors I[kappa]B-[alpha] and I[kappa]B-[beta] by Western analysis. Hcy also increased intracellular reactive oxygen species by NAD(P)H oxidase activation, as shown by the membrane translocation of its [p47.sup.phox] subunit. NF-[kappa]B inhibitors decreased Hey-induced intracellular reactive oxygen species and VCAM-1 expression. Finally, we found that nutritionally relevant concentrations of RSV and HT, but not folate and vitamin B6, reduce (by >60% at [10.sup.-6] mol/1) Hcy-induced VCAM-1 expression and monocytoid cell adhesion to the endothelium. These data indicate that pathophysiologically relevant Hcy concentrations induce VCAM-1 expression through a prooxidant mechanism involving NF-[kappa]B. Natural Mediterranean diet antioxidants can inhibit such activation, suggesting their possible therapeutic role in Hey-induced vascular damage. atherosclerosis; endothelial activation; homocysteine; gene expression; inflammation; nuclear factor-[kappa]B

Published
2007

36. List of Contributors

Author

Abia, Rocio, primary, Aguila, Marcia Barbosa, additional, Alcaraz, Miguel, additional, Aldini, Giancarlo, additional, Alonso, Alvaro, additional, de Cienfuegos, Gerardo Álvarez, additional, Amaral, Joana S., additional, Amirante, Paolo, additional, Amores, Victoria, additional, Amoruso, Angela, additional, Andrade, Paula B., additional, Andreadou, I., additional, Angioni, Alberto, additional, Ankan, Aysun, additional, Antunes, Lusânia Maria Greggi, additional, Apetrei, C., additional, Aramendía, María A., additional, Arbones-Mainar, Jose Miguel, additional, Arias, José L., additional, Arienti, Giuseppe, additional, Armenta, Sergio, additional, Assy, Nimmer, additional, Audi, Nama’a, additional, Azadmard-Damirchi, Sodeif, additional, Azqueta, Amaia, additional, Badiu, Diana, additional, Ballabio, Davide, additional, Balesteros, Manoela Ruchiga, additional, Ballesteros, Evaristo, additional, Barbosa, Décio Sabbatini, additional, Barbouti, Alexandra, additional, Bardelli, Claudio, additional, Batanero, Eva, additional, Baumann, Leslie, additional, Benavente-García, Obdulio, additional, Becker, Peter, additional, Bendini, Alessandra, additional, Benedetti, Simona, additional, Beretta, Giangiacomo, additional, Bermudez, Beatriz, additional, Bes-Rastrollo, Maira, additional, Bianchi, Maria de Lourdes Pires, additional, Bisignano, Giuseppe, additional, Blanco, Santos, additional, Boskou, George, additional, Bracci, Tania, additional, Bravo, Laura, additional, Brenes, Manuel, additional, Brescia, Maria Antonietta, additional, Briasoulis, Evangelos, additional, Brunelleschi, Sandra, additional, Bucci, Remo, additional, Buckland, Genevieve, additional, Buratti, Susanna, additional, Buróníó, María I., additional, Busconi, Matteo, additional, Cabello-Moruno, Rosana, additional, Caboni, Pierluigi, additional, Cabras, Paolo, additional, Caggia, Cinzia, additional, Camuesco, Desiree, additional, Cancelas, Jesús, additional, Capasso, Giovambattista, additional, Capote, F. Priego, additional, Cárdenas, Soledad, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pancorbo, Alegria, additional, Carnuccio, Rosa, additional, Carrera, María Pilar, additional, Carretero, Antonio Segura, additional, Casado, Francisco Javier, additional, Castillo, Julián, additional, Caturla, Nuria, additional, Cerretani, Lorenzo, additional, Chillemi, Rosa, additional, Chiou, Antonia, additional, Choi, Shin-Geon, additional, Christian, Mildred S., additional, Chondrogianni, Niki, additional, Churruca, Itziar, additional, Cirugeda, Miguel de la Guardia, additional, de Castro, Antonio, additional, De Caterina, Raffaele, additional, Cavaliere, Chiara, additional, Chinou, Ioanna, additional, Clodoveo, Maria Lisa, additional, Coimbra, Manuel A., additional, Conte, Lanfranco S., additional, Cosio, M. Stella, additional, Covas, Maria Isabel, additional, Coxam, Véronique, additional, Cunha, Sara C., additional, Curiel, Jose Antonio, additional, D’Angelo, Stefania, additional, Daniel, Hannelore, additional, Davicco, Marie-Jeanne, additional, De Bonis, Maria Luigia, additional, De Castro, M.D. Luque, additional, de la Higuera, Manuel, additional, de la Puerta, Cristina, additional, de las Rivas, Blanca, additional, de la Torre, Rafael, additional, Delcuratolo, Debora, additional, De Leonardis, Antonella, additional, De Lucia, Maria, additional, de Oliveira, Marcone Augusto Leal, additional, de Pablo, Manuel A., additional, De Roos, Baukje, additional, De Saja, Jose A., additional, De Stefano, Daniela, additional, Di Bella, Giuseppa, additional, Dichi, Isaias, additional, Diener, Robert M., additional, Dirsch, Verena M., additional, d’Ischia, Marco, additional, Driss, Fathi, additional, Dugo, Giacomo, additional, Dutta, Paresh C., additional, Ebizuk, Yutaka, additional, El-Benna, Jamel, additional, Esteban, Francisco J., additional, Estepa, Amparo, additional, da Silva, Joaquim C.G. Esteves, additional, Fabiani, Roberto, additional, Facino, Roberto Maffei, additional, Faria, M.A., additional, Faria, Miguel, additional, Fernandes, José O., additional, Fernandez-Gutierrez, Alberto, additional, Fernández-Montesinos, Rafael, additional, Fernández-Navarro, Mónica, additional, Fernández-Quintela, Alfredo, additional, Faria, Adriana Ferreira, additional, Fitó, Montserrat, additional, Fogher, Corrado, additional, Foglia, Patrizia, additional, Franconi, Flavia, additional, Fregapane, Giuseppe, additional, Fujimoto, Kazuma, additional, Fujise, Takehiro, additional, Furneri, Pio Maria, additional, Gallardo, Visitación, additional, Galletti, Patrizia, additional, Galvez, Julio, additional, Garcia, Aranzazu, additional, García, I.M., additional, García-Luna, Pedro P., additional, Garrido-Fernández, Antonio, additional, Garrigues, Salvador, additional, Geelen, Math J.H., additional, Geladopoulos, Taxiarchis, additional, Giamarellos-Bourboulis, Evangelos J., additional, Frenich, Antonia Garrido, additional, Galaris, Dimitrios, additional, Gilani, Anwarul Hassan, additional, Gill, Chris I.R., additional, Giovannini, Claudio, additional, Glatzle, Jörg, additional, Gnoni, Gabriele V., additional, Gomes, Tommaso, additional, Gómez-Rico, Aurora, additional, Gonos, Efstathios S., additional, Gonzalez, Carlos A., additional, Goya, Luis, additional, Grosovski, Maria, additional, Gutiérrez, Guillermo Rodriguez, additional, Hartmann, Marie-Andrée, additional, Hashim, Yumi Z., additional, Hu, Xiuli, additional, Ieri, Francesca, additional, Iliodromitis, Efstathios K., additional, Iwakiri, Ryuichi, additional, Juan, M. Emilia, additional, Kalogeropoulos, Nick, additional, Kalua, Curtis, additional, Khan, Arif-ullah, additional, Khymenets, Olha, additional, Kosti, Rena, additional, Kotsiou, Antonia, additional, Kremastinos, Dimitrios Th., additional, Lafont, Fernando, additional, Laganà, Aldo, additional, Landete, Jose Maria, additional, La Pera, Lara, additional, Lapucci, Chiara, additional, Lavermicocca, Paola, additional, Léger, Claude Louis, additional, Lehotay, Steven J., additional, Leone, Alessandro, additional, Liu, Jun, additional, Turco, Vincenzo Lo, additional, Lopez, Sergio, additional, de Cerain, Adela Lopez, additional, de Felipe, Felix Lopez, additional, López-Feria, Silvia, additional, de la Serrana, Herminia López-Garcia, additional, López-López, Antonio, additional, López-Martinez, Maria Carmen, additional, Lopez-Miranda, Jose, additional, La Torre, Giovanna Loredana, additional, Lucas, Ricardo, additional, Lupiáñez, José A., additional, Luque, Rafael, additional, Macciola, Vincenzo, additional, Madar, Zecharia, additional, Mafra, Isabel, additional, Magrì, Andrea D., additional, Magrì, Antonio L., additional, Maiuri, Maria Chiara, additional, Malaisse, Willy J., additional, Mañas, Mariano, additional, Mandarim-de-Lacerda, Carlos Alberto, additional, Manna, Caterina, additional, Mannina, Luisa, additional, Mannino, Saverio, additional, Marinas, Alberto, additional, Marinas, Jose M., additional, Marini, Federico, additional, Markaki, Panagiota, additional, Martín, M. Angeles, additional, Martínez, María Alba, additional, Martinez-Gonzalez, Miguel A., additional, Martínez-Gracia, María Victoria, additional, Martinez-Martos, José Manuel, additional, Martínez-Victoria, Emilio, additional, Masella, Roberta, additional, Massaro, Marika, additional, Mastovska, Katerina, additional, Mateos, Raquel, additional, Mazzoni, Michela, additional, Menéndez-Menéndez, Javier, additional, Medina, Eduardo, additional, Medina, Jose M., additional, Micol, Vicente, additional, Mikros, Emmanuel, additional, Mitjavila, Maria Teresa, additional, Montaño, Alfredo, additional, Morales, Juan Carlos, additional, Morcillo, Sonsoles, additional, Moreno, Juan José, additional, Moreno, Paola, additional, Moret, Sabrina, additional, Moros, Javier, additional, Morozzi, Guido, additional, Motilva, Maria-Jose, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Napoli, Daniela, additional, Napolitano, Alessandra, additional, Nassar, Faris, additional, Nasti, Raffaella, additional, Natali, Francesco, additional, Natalini, Paolo, additional, Nunes, Cláudia S., additional, Nychas, George, additional, Oliveira, M. Beatriz P.P., additional, Orihara, Yutaka, additional, Ortega, Almudena, additional, Ortega-García, Francisca, additional, Osada, Jesús, additional, Özdemir, Durmuş, additional, Öztürk, Betül, additional, Pacheco, Yolanda M., additional, Paice, Alistair G., additional, Palmerini, Carlo A., additional, Panagiotakos, Demosthenes, additional, Panagou, E.Z., additional, Panzella, Lucia, additional, Papoti, V.T., additional, Paradiso, Vito Michele, additional, Pariente, José Antonio, additional, Patel, Vinood B., additional, Peinado, M. Ángeles, additional, Pellicanò, Teresa Maria, additional, Peragon, Juan, additional, Perez-Jimenez, Francisco, additional, Perez-Martinez, Pablo, additional, Perona, Javier Sanchez, additional, Piperno, Anna, additional, Planas, Joana M., additional, Pollicino, Donatella, additional, Polzonetti, Valeria, additional, Populin, Tiziana, additional, Portillo, Maria P., additional, Pozo, David, additional, Prenzler, Paul, additional, Prieto, Pablo G., additional, Pucciarelli, Stefania, additional, Puel, Caroline, additional, Puertollano, Elena, additional, Puertollano, María A., additional, Quesada-Granados, Jose Javier, additional, Rajendram, Rajkumar, additional, Ramírez-Expósito, María Jesús, additional, Ramos, Sonia, additional, Ramos-Martos, Natividad, additional, Randazzo, Cinzia L., additional, Rando, Rossana, additional, Reiter, Russel J., additional, Rejano, Luis, additional, Rhee, Hae-Ik, additional, Robards, Kevin, additional, Rodriguez, Hector, additional, Rodríguez-Cabezas, Maria Elena, additional, Rodríguez-Manero, Moises, additional, Rodríguez-Méndez, María L., additional, Rodríguez, Rosalía, additional, Rodriguez-Rodriguez, Rosalia, additional, Romani, Annalisa, additional, Romero, Concepción, additional, Romero, Maria-Paz, additional, Romero-Gonzalez, Roberto, additional, Rose, Martin, additional, Rossi, Mauro, additional, Rotondi, Annalisa, additional, Rowland, Ian R., additional, Ruiz, Adolfina, additional, Ruiz-Gutiérrez, Valentina, additional, Russo, Francesco, additional, Ryan, Danielle, additional, Sabatini, Nadia, additional, Sacco, Antonio, additional, Sahan, Yasemin, additional, Saitta, Marcello, additional, Salvador, Maria Desamparados, additional, Samperi, Roberto, additional, Samaniego-Sánchez, Cristina, additional, Sánchez, Antonio Higinio, additional, Sánchez-Navarro, Maria Rosa, additional, Sancho, Verónica, additional, Santos-González, Mónica, additional, Saraiva, Jorge A., additional, Scampicchio, Matteo, additional, Scazzocchio, Beatrice, additional, Schmitt, Christoph A., additional, Schwartz, Betty, additional, Sciuto, Sebastiano, additional, Scoditti, Egeria, additional, Seabra, Rosa M., additional, Sebastiani, Luca, additional, Segre, Anna Laura, additional, Segura, Antonio, additional, Servili, Maurizio, additional, Shiraishi, Ryosuke, additional, Siculella, Luisa, additional, Simão, Andréa Colado, additional, Sindona, Giovanni, additional, Sivakumar, Ganapathy, additional, Skaltsounis, Alexios-Leandros, additional, Smith, Amos B., additional, Spatafora, Carmela, additional, Sperry, Jeffrey B., additional, Soares, Mario J., additional, Soriguer, Federico, additional, Srirajaskanthan, Rajaventhan, additional, Stitia, Naïm, additional, Tabernero, Arantxa, additional, Tagarelli, Antonio, additional, Tai, Fuju, additional, Tamborrino, Antonia, additional, Tassou, C.C., additional, Tesseromatis, Christine, additional, Todeschini, Roberto, additional, Torrecilla, Jose S., additional, Trikib, Saïda, additional, Tringali, Corrado, additional, Tsakiris, Ioannis N., additional, Tsatsakis, Aristidis M., additional, Tsimidou, M.Z., additional, Uccella, Nicola A., additional, Urbano, Francisco J., additional, Valcarcel, Miguel, additional, Valencia-Serrano, Félix, additional, Valentão, Patrícia, additional, Valverde, Isabel, additional, Varela, Lourdes M., additional, Varì, Rosaria, additional, Simas Vaz, Fernando Antonio, additional, Vettorazzi, Ariane, additional, Vichi, Stefania, additional, Vidal, José Luis Martínez, additional, Villalba, José M., additional, Villalba, Mayte, additional, Villanueva-Peñacarrillo, María L., additional, Vincenzetti, Silvia, additional, Vita, Alberto, additional, Vlahov, Giovanna, additional, Wang, Wei, additional, Weisberg, Edmund, additional, Wenzel, Uwe, additional, Won, Se-Ra, additional, Wu, Bin, additional, Yago, María Dolores, additional, Zabaras, Dimitrios, additional, Zappia, Vincenzo, additional, Zarzuelo, Antonio, additional, and Zhang, Luyong, additional

Published
2010
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39. Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease

Author

Ruskovska, Tatjana, primary, Massaro, Marika, additional, Carluccio, Maria Annunziata, additional, Arola-Arnal, Anna, additional, Muguerza, Begoña, additional, Vanden Berghe, Wim, additional, Declerck, Ken, additional, Bravo, Francisca Isabel, additional, Calabriso, Nadia, additional, Combet, Emilie, additional, Gibney, Eileen R., additional, Gomes, Andreia, additional, Gonthier, Marie-Paule, additional, Kistanova, Elena, additional, Krga, Irena, additional, Mena, Pedro, additional, Morand, Christine, additional, Nunes dos Santos, Claudia, additional, de Pascual-Teresa, Sonia, additional, Rodriguez-Mateos, Ana, additional, Scoditti, Egeria, additional, Suárez, Manuel, additional, and Milenkovic, Dragan, additional

Published
2020
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41. The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation

Author

Carpi, Sara, primary, Scoditti, Egeria, additional, Massaro, Marika, additional, Polini, Beatrice, additional, Manera, Clementina, additional, Digiacomo, Maria, additional, Esposito Salsano, Jasmine, additional, Poli, Giulio, additional, Tuccinardi, Tiziano, additional, Doccini, Stefano, additional, Santorelli, Filippo Maria, additional, Carluccio, Maria Annunziata, additional, Macchia, Marco, additional, Wabitsch, Martin, additional, De Caterina, Raffaele, additional, and Nieri, Paola, additional

Published
2019
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46. Analysis of nutrigenomic effects of flavanols: a systematic bioinformatic evaluation of flavanol-modulated gene expressions in cell models of cardiometabolic disease

Author

Massaro, Marika, Ruskovska, Tatjana, Pascual-Teresa, Sonia de, Krga, Irena, Vanden Berghe, Wim, Kistanova, Elena, Mena, Pedro, Gonthier, Marie-Paule, Nunes dos Santos, Claudia, Gomes, Andreia, Scoditti, Egeria, Carluccio, Maria Annunziata, Combet, Emilie, Calabriso, Nadia, Arola Arnal, Anna, Muguerza Marquínez, Maria Begoña, Suárez Recio, Manuel, Bravo Vázquez, Francisca Isabel, Gibney, Eileen R., Rodríguez-Mateos, Ana, Morand, Christine, and Milenkovic, Dragan

Abstract

Resumen del trabajo presentado al 13th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN), celebrado en Cambridge (UK) del 12 al 13 de julio de 2019., [Introduction]: The role of flavanols in terms of gene regulation in various cell models relevant to cardiometabolic disease has never been systematically addressed. Therefore, we conducted a systematic literature search and comprehensive bioinformatic analysis of the genes which expression has been reported as affected by flavanols in the cells defining the cardiometabolic health (hepatocytes, adipocytes, endothelial, smooth muscle and immune cells), to decipher molecular mechanisms of action underlying their cardiometabolic health properties. [Methods]: Literature search was performed in PubMed and Web of Science using pre-defined criteria (pure compounds and metabolites, no extracts, physiologically relevant concentrations). Identified differentially expressed genes were analyzed by several bioinformatic tools including: MetaCore, GeneTrail2 (for access to KEGG and BioCarta databases), Metascape and OmicsNet. [Results]: Analysis of extracted data from the literature identified 54 differentially expressed genes at mRNA level. Gene network analysis revealed that these genes are involved in inflammation, immune response, cell adhesion, apoptosis and cell signaling. Deeper analysis of their functional roles revealed the pathways such as TNF signaling pathway, NF-kappa B signaling pathway, Leukocyte transendothelial migration and Cell adhesion molecules. Studied cell types respond differently on the flavanol exposure, but inflammatory response is a common mechanism. Transcriptional factors, such as PPARG, NFKB1, CREB1 or STAT3, and miRNAs such as mir-335-5p, mir-16-5p, mir-124-3p or mir-26b-5p have been identified as regulators of gene expression by flavanols. [Conclusions]: The results of this systematic analysis of nutrigenomic effects of flavanols will support the future setup of nutrigenetic studies to pave the way for individualized dietary recommendations.

Published
2019

48. Release of VEGF from Dental Implant Surface (IML® Implant) Coated with Concentrated Growth Factors (CGF) and the Liquid Phase of CGF (LPCGF): In Vitro Results and Future Expectations

Author

Palermo, Andrea, primary, Ferrante, Franco, additional, Stanca, Eleonora, additional, Damiano, Fabrizio, additional, Gnoni, Antonio, additional, Batani, Tiziano, additional, Carluccio, Maria Annunziata, additional, Demitri, Christian, additional, and Siculella, Luisa, additional

Published
2019
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49. Phenolic extracts from whole wheat biofortified bread dampen overwhelming inflammatory response in human endothelial cells and monocytes: major role of VCAM-1 and CXCL-10.

Author

Calabriso, Nadia, Massaro, Marika, Scoditti, Egeria, Pasqualone, Antonella, Laddomada, Barbara, and Carluccio, Maria Annunziata

Subjects
ENRICHED foods, BIOLOGICAL models, BREAD, CELL adhesion molecules, CHEMOKINES, CYTOKINES, INFLAMMATION, INTERLEUKINS, MONOCYTES, PHENOLS, TUMOR necrosis factors, STATISTICAL significance, OXIDATIVE stress, UMBILICAL veins, ENDOTHELIAL cells, IN vitro studies
Abstract

Purpose: The aim of the study was to evaluate the vascular health properties of extracts from biofortified bread, obtained by adding different durum wheat milling by-products rich in phenolic compounds, by analyzing their effects on overwhelming inflammatory response in endothelial cells and monocytes, two main players of atherogenesis. Methods: Human umbilical vein endothelial cells or U937 monocytes were incubated with increasing concentrations (1, 5, 10 μg/mL) of biofortified bread polyphenol extracts or corresponding pure phenolic acids before stimulation with lipopolysaccharide (LPS). We analyzed the endothelial-monocyte adhesion and related endothelial adhesion molecules. The expression of chemokines and pro-inflammatory cytokines was also measured in LPS-stimulated endothelial cells and monocytes as well as intracellular oxidative stress. Results: Biofortified bread extracts inhibited monocyte adhesion to LPS-stimulated endothelial cells, in a concentration-dependent manner by reducing mainly endothelial VCAM-1 expression. Phenolic acid extracts contained in 10 mg biofortified bread downregulated the LPS-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 as well as pro-inflammatory cytokines TNF-α and IL-1β, in endothelial cells and monocytes, with CXCL-10 as the most reduced inflammatory mediator. Among phenolic acids of biofortified bread, ferulic, sinapic, and p-coumaric acids significantly inhibited the LPS-stimulated CXCL-10 expression in vascular cells. The reduced pro-inflammatory response was related to a slightly but significant reduction of intracellular oxidative stress. Conclusions: Our findings suggest the bread biofortified with selected durum wheat milling by-products as a source of phenolic acids with multiple anti-inflammatory and anti-atherosclerotic properties, which could help to counteract or prevent inflammatory vascular diseases. [ABSTRACT FROM AUTHOR]

Published
2020
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