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Objectives Using free-text clinical notes and reports from hospitalised patients, determine the performance of natural language processing (NLP) ascertainment of Framingham heart failure (HF) criteria and phenotype.Study design A retrospective observational study design of patients hospitalised in 2015 from four hospitals participating in the Atherosclerosis Risk in Communities (ARIC) study was used to determine NLP performance in the ascertainment of Framingham HF criteria and phenotype.Setting Four ARIC study hospitals, each representing an ARIC study region in the USA.Participants A stratified random sample of hospitalisations identified using a broad range of International Classification of Disease, ninth revision, diagnostic codes indicative of an HF event and occurring during 2015 was drawn for this study. A randomly selected set of 394 hospitalisations was used as the derivation dataset and 406 hospitalisations was used as the validation dataset.Intervention Use of NLP on free-text clinical notes and reports to ascertain Framingham HF criteria and phenotype.Primary and secondary outcome measures NLP performance as measured by sensitivity, specificity, positive-predictive value (PPV) and agreement in ascertainment of Framingham HF criteria and phenotype. Manual medical record review by trained ARIC abstractors was used as the reference standard.Results Overall, performance of NLP ascertainment of Framingham HF phenotype in the validation dataset was good, with 78.8%, 81.7%, 84.4% and 80.0% for sensitivity, specificity, PPV and agreement, respectively.Conclusions By decreasing the need for manual chart review, our results on the use of NLP to ascertain Framingham HF phenotype from free-text electronic health record data suggest that validated NLP technology holds the potential for significantly improving the feasibility and efficiency of conducting large-scale epidemiologic surveillance of HF prevalence and incidence.

Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such as phenolic compounds and their antioxidant activities. The abundance and complexity of these bio-constituents highlight the need for well-defined in vitro characterization and quantification of the plant extracts/preparations that can translate to in vivo effects and hopefully to clinical use. This review article seeks to provide relevant information about the applicability of cell-based assays in assessing anti-cytotoxicity of phytochemicals considering several traditional and current methods.

Pioneering networks of cameras that can search for wildland fire signatures have been in development for some years (High Performance Wireless Research & Education Network—HPWREN cameras and the ALERT Wildfire camera). While these cameras have proven their worth in monitoring fires reported by other means, we have developed a functioning prototype system that can detect smoke from fires usually within 15 min of ignition, while averaging less than one false positive per day per camera. This smoke detection system relies on machine learning-based image recognition software and a cloud-based work-flow capable of scanning hundreds of cameras every minute. The system is operating around the clock in Southern California and has already detected some fires earlier than the current best methods—people calling emergency agencies or satellite detection from the Geostationary Operational Environmental Satellite (GOES) satellites. This system is already better than some commercial systems and there are still many unexplored methods to further improve accuracy. Ground-based cameras are not going to be able to detect every wildfire, and so we are building a system that combines the best of terrestrial camera-based detection with the best approaches to satellite-based detection.

Society needs information about how vegetation communities in coastal regions will be impacted by hydrologic changes associated with climate change, particularly sea level rise. Due to anthropogenic influences which have significantly decreased natural coastal vegetation communities, it is important for us to understand how remaining natural communities will respond to sea level rise. The Cape Canaveral Barrier Island complex (CCBIC) on the east central coast of Florida is within one of the most biologically diverse estuarine systems in North America and has the largest number of threatened and endangered species on federal property in the contiguous United States. The high level of biodiversity is susceptible to sea level rise. Our objective was to model how vegetation communities along a gradient ranging from hydric to upland xeric on CCBIC will respond to three sea level rise scenarios (0.2 m, 0.4 m, and 1.2 m). We used a probabilistic model of the current relationship between elevation and vegetation community to determine the impact sea level rise would have on these communities. Our model correctly predicted the current proportions of vegetation communities on CCBIC based on elevation. Under all sea level rise scenarios the model predicted decreases in mesic and xeric communities, with the greatest losses occurring in the most xeric communities. Increases in total area of salt marsh were predicted with a 0.2 and 0.4 m rise in sea level. With a 1.2 m rise in sea level approximately half of CCBIC's land area was predicted to transition to open water. On the remaining land, the proportions of most of the vegetation communities were predicted to remain similar to that of current proportions, but there was a decrease in proportion of the most xeric community (oak scrub) and an increase in the most hydric community (salt marsh). Our approach provides a first approximation of the impacts of sea level rise on terrestrial vegetation communities, including important xeric upland communities, as a foundation for management decisions and future modeling.

Current and planned wildfire detection systems are impressive but lack both sensitivity and rapid response times. A small telescope with modern detectors and significant computing capacity in geosynchronous orbit can detect small (12 m2) fires on the surface of the earth, cover most of the western United States (under conditions of moderately clear skies) every few minutes or so, and attain very good signal-to-noise ratio against Poisson fluctuations in a second. Hence, these favorable statistical significances have initiated a study of how such a satellite could operate and reject the large number of expected systematic false alarms from a number of sources. Here we present both studies of the backgrounds in Geostationary Operational Environmental Satellites (GOES) 15 data and studies that probe the sensitivity of a fire detection satellite in geosynchronous orbit. We suggest a number of algorithms that can help reduce false alarms, and show efficacy on a few. Early detection and response would be of true value in the United States and other nations, as wildland fires continue to severely stress resource managers, policy makers, and the public, particularly in the western US. Here, we propose the framework for a geosynchronous satellite with modern imaging detectors, software, and algorithms able to detect heat from early and small fires, and yield minute-scale detection times.

Integrin αvβ3 is involved in varied cell biological activities, including angiogenesis, cell adhesion, and migration on several extracellular matrix components. Although αvβ3 is not typically expressed in epithelial cells, it is expressed in macrophages, activated leukocytes, cytokine-stimulated endothelial cells, osteoclasts, and certain invasive tumors. Interestingly, the adhesion and migration of breast cancer cells on bone matrix are mediated, in part, by αvβ3. Similar to breast cancer cells, prostate cancer cells preferentially metastasize to the bone. The biological events that mediate this metastatic pattern of prostate cancer are not well defined. This review discusses the role αvβ3 plays in prostate cancer progression, with specific emphasis on bone metastasis and on αvβ3 signaling in prostate cancer cells. The data suggest that αvβ3, in part, facilitates prostate cancer metastasis to bone by mediating prostate cancer cell adhesion to and migration on osteopontin and vitronectin, which are common proteins in the bone microenvironment. These biological events require the activation of focal adhesion kinase and the subsequent activation of PI-3 kinase/Akt signaling pathway.

After his world record wheat harvest in 1916, (1) Charles Sherwood Noble (1873-1957) of Nobleford, Alberta, had tried to 'up' that record crop in 1917. He just missed his target [...]

In 1903, Charles Noble, a thirty-year-old talented and progressive farmer, relocated from North Dakota to Claresholm. He had a small farm north of town but also opened a butcher shop, [...]

In the 1940s Canada became home to many thousands of German Prisoners ofWar (POWs) who had been captured by Britain and its allies. Britain's stressed resources could not afford to [...]