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1. The instrument suite of the European Spallation Source

Author

Andersen, K.H., Argyriou, D.N, Jackson, A.J., Houston, J., Henry, P.F., Deen, P.P., Toft-Petersen, R., Beran, P., Strobl, M., Arnold, T., Wacklin-Knecht, H., Tsapatsaris, N., Oksanen, E., Woracek, R., Schweika, W., Mannix, D., Hiess, A., Kennedy, S., Kirstein, O., Petersson Årsköld, S., Taylor, J., Hagen, M.E., Laszlo, G., Kanaki, K., Piscitelli, F., Khaplanov, A., Stefanescu, I., Kittelmann, Th., Pfeiffer, D., Hall-Wilton, R., Lopez, C.I., Aprigliano, G., Whitelegg, L., Moreira, F.Y., Olsson, M., Bordallo, H.N., Martín-Rodríguez, D., Schneider, H., Sharp, M., Hartl, M., Nagy, G., Ansell, S., Pullen, S., Vickery, A., Fedrigo, A., Mezei, F., Arai, M., Heenan, R.K., Halcrow, W., Turner, D., Raspino, D., Orszulik, A., Cooper, J., Webb, N., Galsworthy, P., Nightingale, J., Langridge, S., Elmer, J., Frielinghaus, H., Hanslik, R., Gussen, A., Jaksch, S., Engels, R., Kozielewski, T., Butterweck, S., Feygenson, M., Harbott, P., Poqué, A., Schwaab, A., Lieutenant, K., Violini, N., Voigt, J., Brückel, T., Koenen, M., Kämmerling, H., Babcock, E., Salhi, Z., Wischnewski, A., Heynen, A., Désert, S., Jestin, J., Porcher, F., Fabrèges, X., Fabrèges, G., Annighöfer, B., Klimko, S., Dupont, Th., Robillard, Th., Goukassov, A., Longeville, S., Alba-Simionesco, Ch., Bourges, Ph., Guyon Le Bouffy, J., Lavie, P., Rodrigues, S., Calzada, E., Lerche, M., Schillinger, B., Schmakat, Ph., Schulz, M., Seifert, M., Lohstroh, W., Petry, W., Neuhaus, J., Loaiza, L., Tartaglione, A., Glavic, A., Schütz, S., Stahn, J., Lehmann, E., Morgano, M., Schefer, J., Filges, U., Klauser, Ch., Niedermayer, Ch., Fenske, J., Nowak, G., Rouijaa, M., Siemers, D.J., Kiehn, R., Müller, M., Carlsen, H., Udby, L., Lefmann, K., Birk, J.O., Holm-Dahlin, S., Bertelsen, M., Hansen, U. Bengaard, Olsen, M.A., Christensen, M., Iversen, K., Christensen, N.B., Rønnow, H.M., Freeman, P.G., Hauback, B.C., Kolevatov, R., Llamas-Jansa, I., Orecchini, A., Sacchetti, F., Petrillo, C., Paciaroni, A., Tozzi, P., Zanatta, M., Luna, P., Herranz, I., del Moral, O.G., Huerta, M., Magán, M., Mosconi, M., Abad, E., Aguilar, J., Stepanyan, S., Bakedano, G., Vivanco, R., Bustinduy, I., Sordo, F., Martínez, J.L., Lechner, R.E., Villacorta, F.J., Šaroun, J., Lukáš, P., Markó, M., Zanetti, M., Bellissima, S., del Rosso, L., Masi, F., Bovo, C., Chowdhury, M., De Bonis, A., Di Fresco, L., Scatigno, C., Parker, S.F., Fernandez-Alonso, F., Colognesi, D., Senesi, R., Andreani, C., Gorini, G., Scionti, G., and Schreyer, A.

Published
2020
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3. Low birthweight and maternal smoking as predictors of infant lung function from a South African birth cohort within low socioeconomic communities.

Author

Muttoo, S., Jeena, P. M., Röösli, M., Olin, A. C., Carlsen, H. K., Asharam, K., Naidoo, G., Mitku, A. A., and Naidoo, R. N.

Subjects
COHORT analysis, BIRTH weight, EXPIRATORY flow, LUNGS, INFANTS
Abstract

Background. Early assessment of infant lung function (ILF) is necessary to improve our understanding of factors that determine long-term respiratory health. Objective. To identify predictors of lung function among infants aged 6 weeks, 6, 12 and 24 months, from low socioeconomic settings, enrolled within the Mother and Child in the Environment (MACE) study. Methods. ILF tests were performed assessing multiple breath washout and tidal breathing during spontaneous sleep. Several risk factors, relating to infant growth, maternal and environmental exposures, were assessed cross-sectionally against the lung function parameters in multivariable models for each age group. Results. Maternal smoking during pregnancy affected the ratio of time to peak expiratory flow, showing a decline across the age groups, while being statistically significant (β (95% confidence interval (CI)) at 6 weeks (-24.6% (-43.92 - -4.59)) and 12 months (-12.68 (-25.25 - -0.11)). Low birthweight was associated with a lower tidal volume at 6 weeks (-5.99 mL (-9.59 - -2.39)), 6 months (-15.02 mL (-22.48 - -7.57)) and 12 months (-23.7 mL (-35.55 - -11.85)), compared with those with normal birthweight. This was further observed for minute ventilation at 6 weeks (-157.78 mL/min (-338.95 - 23.38)), 6 months (-325.57 mL/min (-619.06 - -32.08)) and 12 months (-527.58 mL/min (-947.85 - -107.32)), though less evident at 24 months. Conclusion. Low birthweight was the main predictor for low tidal volumes and minute ventilation at 6 weeks, with smaller differences observed at 12 and 24 months. Lung function development early in life is primarily driven by infant size and postnatal growth factors, consistent with other studies. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Forum on Scenarios for Climate and Societal Futures: Meeting Report

Author

van Ruijven, B., Carlsen, H., Chaturvedi, V., Ebi, K., Fuglestvedt, J., Gasalla, M., Harrison, P.A., Kok, K., Kriegler, E., Leininger, J., Monteith, S., O'Neill, B.C., Pereira, L., Pichs-Madruga, R., Riahi, K., Seneviratne, S., Sillman, J., Takahashi, K., Tebaldi, C., and Van Vuuren, D.P.

Abstract

The second Scenarios Forum took place in June 2022 in Laxenburg, Austria. The goal of the second Scenarios Forum was to bring together the diverse set of communities using or developing scenarios in climate change and sustainability analysis to exchange experiences, ideas, and lessons learned; identify opportunities for synergies and collaboration between communities; reflect on the use of scenarios; and identify knowledge gaps for future research. The Scenarios Forum 2022 brought together over 500 researchers onsite and online to share experiences to date on progress toward this goal. The Forum confirmed that the SSP-RCP framework is being widely and increasingly used across a variety of research communities and assessment processes in the climate and biodiversity communities. Key discussions on future needs during the Scenarios Forum included the need for expansion of the solution space to facilitate a wider diversity of response strategies, broadening the labeling of scenarios to facilitate connection to other communities, initiating a discussion on high-end community scenarios and the tension in the scenarios framework between providing building-blocks for scientists and identifying key community-level scenarios.

Published
2022

6. The instrument suite of the European Spallation Source

Author

Andersen, K, Argyriou, D, Jackson, A, Houston, J, Henry, P, Deen, P, Toft-Petersen, R, Beran, P, Strobl, M, Arnold, T, Wacklin-Knecht, H, Tsapatsaris, N, Oksanen, E, Woracek, R, Schweika, W, Mannix, D, Hiess, A, Kennedy, S, Kirstein, O, Petersson Arskold, S, Taylor, J, Hagen, M, Laszlo, G, Kanaki, K, Piscitelli, F, Khaplanov, A, Stefanescu, I, Kittelmann, T, Pfeiffer, D, Hall-Wilton, R, Lopez, C, Aprigliano, G, Whitelegg, L, Moreira, F, Olsson, M, Bordallo, H, Martin-Rodriguez, D, Schneider, H, Sharp, M, Hartl, M, Nagy, G, Ansell, S, Pullen, S, Vickery, A, Fedrigo, A, Mezei, F, Arai, M, Heenan, R, Halcrow, W, Turner, D, Raspino, D, Orszulik, A, Cooper, J, Webb, N, Galsworthy, P, Nightingale, J, Langridge, S, Elmer, J, Frielinghaus, H, Hanslik, R, Gussen, A, Jaksch, S, Engels, R, Kozielewski, T, Butterweck, S, Feygenson, M, Harbott, P, Poque, A, Schwaab, A, Lieutenant, K, Violini, N, Voigt, J, Bruckel, T, Koenen, M, Kammerling, H, Babcock, E, Salhi, Z, Wischnewski, A, Heynen, A, Desert, S, Jestin, J, Porcher, F, Fabreges, X, Fabreges, G, Annighofer, B, Klimko, S, Dupont, T, Robillard, T, Goukassov, A, Longeville, S, Alba-Simionesco, C, Bourges, P, Guyon Le Bouffy, J, Lavie, P, Rodrigues, S, Calzada, E, Lerche, M, Schillinger, B, Schmakat, P, Schulz, M, Seifert, M, Lohstroh, W, Petry, W, Neuhaus, J, Loaiza, L, Tartaglione, A, Glavic, A, Schutz, S, Stahn, J, Lehmann, E, Morgano, M, Schefer, J, Filges, U, Klauser, C, Niedermayer, C, Fenske, J, Nowak, G, Rouijaa, M, Siemers, D, Kiehn, R, Muller, M, Carlsen, H, Udby, L, Lefmann, K, Birk, J, Holm-Dahlin, S, Bertelsen, M, Hansen, U, Olsen, M, Christensen, M, Iversen, K, Christensen, N, Ronnow, H, Freeman, P, Hauback, B, Kolevatov, R, Llamas-Jansa, I, Orecchini, A, Sacchetti, F, Petrillo, C, Paciaroni, A, Tozzi, P, Zanatta, M, Luna, P, Herranz, I, del Moral, O, Huerta, M, Magan, M, Mosconi, M, Abad, E, Aguilar, J, Stepanyan, S, Bakedano, G, Vivanco, R, Bustinduy, I, Sordo, F, Martinez, J, Lechner, R, Villacorta, F, Saroun, J, Lukas, P, Marko, M, Zanetti, M, Bellissima, S, del Rosso, L, Masi, F, Bovo, C, Chowdhury, M, De Bonis, A, Di Fresco, L, Scatigno, C, Parker, S, Fernandez-Alonso, F, Colognesi, D, Senesi, R, Andreani, C, Gorini, G, Scionti, G, Schreyer, A, Andersen K. H., Argyriou D. N., Jackson A. J., Houston J., Henry P. F., Deen P. P., Toft-Petersen R., Beran P., Strobl M., Arnold T., Wacklin-Knecht H., Tsapatsaris N., Oksanen E., Woracek R., Schweika W., Mannix D., Hiess A., Kennedy S., Kirstein O., Petersson Arskold S., Taylor J., Hagen M. E., Laszlo G., Kanaki K., Piscitelli F., Khaplanov A., Stefanescu I., Kittelmann T., Pfeiffer D., Hall-Wilton R., Lopez C. I., Aprigliano G., Whitelegg L., Moreira F. Y., Olsson M., Bordallo H. N., Martin-Rodriguez D., Schneider H., Sharp M., Hartl M., Nagy G., Ansell S., Pullen S., Vickery A., Fedrigo A., Mezei F., Arai M., Heenan R. K., Halcrow W., Turner D., Raspino D., Orszulik A., Cooper J., Webb N., Galsworthy P., Nightingale J., Langridge S., Elmer J., Frielinghaus H., Hanslik R., Gussen A., Jaksch S., Engels R., Kozielewski T., Butterweck S., Feygenson M., Harbott P., Poque A., Schwaab A., Lieutenant K., Violini N., Voigt J., Bruckel T., Koenen M., Kammerling H., Babcock E., Salhi Z., Wischnewski A., Heynen A., Desert S., Jestin J., Porcher F., Fabreges X., Fabreges G., Annighofer B., Klimko S., Dupont T., Robillard T., Goukassov A., Longeville S., Alba-Simionesco C., Bourges P., Guyon Le Bouffy J., Lavie P., Rodrigues S., Calzada E., Lerche M., Schillinger B., Schmakat P., Schulz M., Seifert M., Lohstroh W., Petry W., Neuhaus J., Loaiza L., Tartaglione A., Glavic A., Schutz S., Stahn J., Lehmann E., Morgano M., Schefer J., Filges U., Klauser C., Niedermayer C., Fenske J., Nowak G., Rouijaa M., Siemers D. J., Kiehn R., Muller M., Carlsen H., Udby L., Lefmann K., Birk J. O., Holm-Dahlin S., Bertelsen M., Hansen U. B., Olsen M. A., Christensen M., Iversen K., Christensen N. B., Ronnow H. M., Freeman P. G., Hauback B. C., Kolevatov R., Llamas-Jansa I., Orecchini A., Sacchetti F., Petrillo C., Paciaroni A., Tozzi P., Zanatta M., Luna P., Herranz I., del Moral O. G., Huerta M., Magan M., Mosconi M., Abad E., Aguilar J., Stepanyan S., Bakedano G., Vivanco R., Bustinduy I., Sordo F., Martinez J. L., Lechner R. E., Villacorta F. J., Saroun J., Lukas P., Marko M., Zanetti M., Bellissima S., del Rosso L., Masi F., Bovo C., Chowdhury M., De Bonis A., Di Fresco L., Scatigno C., Parker S. F., Fernandez-Alonso F., Colognesi D., Senesi R., Andreani C., Gorini G., Scionti G., Schreyer A., Andersen, K, Argyriou, D, Jackson, A, Houston, J, Henry, P, Deen, P, Toft-Petersen, R, Beran, P, Strobl, M, Arnold, T, Wacklin-Knecht, H, Tsapatsaris, N, Oksanen, E, Woracek, R, Schweika, W, Mannix, D, Hiess, A, Kennedy, S, Kirstein, O, Petersson Arskold, S, Taylor, J, Hagen, M, Laszlo, G, Kanaki, K, Piscitelli, F, Khaplanov, A, Stefanescu, I, Kittelmann, T, Pfeiffer, D, Hall-Wilton, R, Lopez, C, Aprigliano, G, Whitelegg, L, Moreira, F, Olsson, M, Bordallo, H, Martin-Rodriguez, D, Schneider, H, Sharp, M, Hartl, M, Nagy, G, Ansell, S, Pullen, S, Vickery, A, Fedrigo, A, Mezei, F, Arai, M, Heenan, R, Halcrow, W, Turner, D, Raspino, D, Orszulik, A, Cooper, J, Webb, N, Galsworthy, P, Nightingale, J, Langridge, S, Elmer, J, Frielinghaus, H, Hanslik, R, Gussen, A, Jaksch, S, Engels, R, Kozielewski, T, Butterweck, S, Feygenson, M, Harbott, P, Poque, A, Schwaab, A, Lieutenant, K, Violini, N, Voigt, J, Bruckel, T, Koenen, M, Kammerling, H, Babcock, E, Salhi, Z, Wischnewski, A, Heynen, A, Desert, S, Jestin, J, Porcher, F, Fabreges, X, Fabreges, G, Annighofer, B, Klimko, S, Dupont, T, Robillard, T, Goukassov, A, Longeville, S, Alba-Simionesco, C, Bourges, P, Guyon Le Bouffy, J, Lavie, P, Rodrigues, S, Calzada, E, Lerche, M, Schillinger, B, Schmakat, P, Schulz, M, Seifert, M, Lohstroh, W, Petry, W, Neuhaus, J, Loaiza, L, Tartaglione, A, Glavic, A, Schutz, S, Stahn, J, Lehmann, E, Morgano, M, Schefer, J, Filges, U, Klauser, C, Niedermayer, C, Fenske, J, Nowak, G, Rouijaa, M, Siemers, D, Kiehn, R, Muller, M, Carlsen, H, Udby, L, Lefmann, K, Birk, J, Holm-Dahlin, S, Bertelsen, M, Hansen, U, Olsen, M, Christensen, M, Iversen, K, Christensen, N, Ronnow, H, Freeman, P, Hauback, B, Kolevatov, R, Llamas-Jansa, I, Orecchini, A, Sacchetti, F, Petrillo, C, Paciaroni, A, Tozzi, P, Zanatta, M, Luna, P, Herranz, I, del Moral, O, Huerta, M, Magan, M, Mosconi, M, Abad, E, Aguilar, J, Stepanyan, S, Bakedano, G, Vivanco, R, Bustinduy, I, Sordo, F, Martinez, J, Lechner, R, Villacorta, F, Saroun, J, Lukas, P, Marko, M, Zanetti, M, Bellissima, S, del Rosso, L, Masi, F, Bovo, C, Chowdhury, M, De Bonis, A, Di Fresco, L, Scatigno, C, Parker, S, Fernandez-Alonso, F, Colognesi, D, Senesi, R, Andreani, C, Gorini, G, Scionti, G, Schreyer, A, Andersen K. H., Argyriou D. N., Jackson A. J., Houston J., Henry P. F., Deen P. P., Toft-Petersen R., Beran P., Strobl M., Arnold T., Wacklin-Knecht H., Tsapatsaris N., Oksanen E., Woracek R., Schweika W., Mannix D., Hiess A., Kennedy S., Kirstein O., Petersson Arskold S., Taylor J., Hagen M. E., Laszlo G., Kanaki K., Piscitelli F., Khaplanov A., Stefanescu I., Kittelmann T., Pfeiffer D., Hall-Wilton R., Lopez C. I., Aprigliano G., Whitelegg L., Moreira F. Y., Olsson M., Bordallo H. N., Martin-Rodriguez D., Schneider H., Sharp M., Hartl M., Nagy G., Ansell S., Pullen S., Vickery A., Fedrigo A., Mezei F., Arai M., Heenan R. K., Halcrow W., Turner D., Raspino D., Orszulik A., Cooper J., Webb N., Galsworthy P., Nightingale J., Langridge S., Elmer J., Frielinghaus H., Hanslik R., Gussen A., Jaksch S., Engels R., Kozielewski T., Butterweck S., Feygenson M., Harbott P., Poque A., Schwaab A., Lieutenant K., Violini N., Voigt J., Bruckel T., Koenen M., Kammerling H., Babcock E., Salhi Z., Wischnewski A., Heynen A., Desert S., Jestin J., Porcher F., Fabreges X., Fabreges G., Annighofer B., Klimko S., Dupont T., Robillard T., Goukassov A., Longeville S., Alba-Simionesco C., Bourges P., Guyon Le Bouffy J., Lavie P., Rodrigues S., Calzada E., Lerche M., Schillinger B., Schmakat P., Schulz M., Seifert M., Lohstroh W., Petry W., Neuhaus J., Loaiza L., Tartaglione A., Glavic A., Schutz S., Stahn J., Lehmann E., Morgano M., Schefer J., Filges U., Klauser C., Niedermayer C., Fenske J., Nowak G., Rouijaa M., Siemers D. J., Kiehn R., Muller M., Carlsen H., Udby L., Lefmann K., Birk J. O., Holm-Dahlin S., Bertelsen M., Hansen U. B., Olsen M. A., Christensen M., Iversen K., Christensen N. B., Ronnow H. M., Freeman P. G., Hauback B. C., Kolevatov R., Llamas-Jansa I., Orecchini A., Sacchetti F., Petrillo C., Paciaroni A., Tozzi P., Zanatta M., Luna P., Herranz I., del Moral O. G., Huerta M., Magan M., Mosconi M., Abad E., Aguilar J., Stepanyan S., Bakedano G., Vivanco R., Bustinduy I., Sordo F., Martinez J. L., Lechner R. E., Villacorta F. J., Saroun J., Lukas P., Marko M., Zanetti M., Bellissima S., del Rosso L., Masi F., Bovo C., Chowdhury M., De Bonis A., Di Fresco L., Scatigno C., Parker S. F., Fernandez-Alonso F., Colognesi D., Senesi R., Andreani C., Gorini G., Scionti G., and Schreyer A.

Abstract

An overview is provided of the 15 neutron beam instruments making up the initial instrument suite of the European Spallation Source (ESS), and being made available to the neutron user community. The ESS neutron source consists of a high-power accelerator and target station, providing a unique long-pulse time structure of slow neutrons. The design considerations behind the time structure, moderator geometry and instrument layout are presented. The 15-instrument suite consists of two small-angle instruments, two reflectometers, an imaging beamline, two single-crystal diffractometers; one for macromolecular crystallography and one for magnetism, two powder diffractometers, and an engineering diffractometer, as well as an array of five inelastic instruments comprising two chopper spectrometers, an inverse-geometry single-crystal excitations spectrometer, an instrument for vibrational spectroscopy and a high-resolution backscattering spectrometer. The conceptual design, performance and scientific drivers of each of these instruments are described. All of the instruments are designed to provide breakthrough new scientific capability, not currently available at existing facilities, building on the inherent strengths of the ESS long-pulse neutron source of high flux, flexible resolution and large bandwidth. Each of them is predicted to provide world-leading performance at an accelerator power of 2 MW. This technical capability translates into a very broad range of scientific capabilities. The composition of the instrument suite has been chosen to maximise the breadth and depth of the scientific impact of the early years of the ESS, and provide a solid base for completion and further expansion of the facility.

Published
2020

9. Climate change scenario services: From science to facilitating action

Author

Auer, C., Kriegler, E., Carlsen, H., Kok, K., Pedde, S., Krey, V., Müller, B., Auer, C., Kriegler, E., Carlsen, H., Kok, K., Pedde, S., Krey, V., and Müller, B.

Abstract

The goal of limiting global warming to well below 2°C as set out in the Paris Agreement calls for a strategic assessment of societal pathways and policy strategies. Besides policy makers, new powerful actors from private sector, including finance, have stepped up to engage in forward-looking assessments of a Paris-compliant and climate-resilient future. Climate change scenarios have addressed this demand by providing scientific insights on the possible pathways ahead to limit warming in line with the Paris climate goal. Despite the increased interest, the potential of climate change scenarios has not been fully unleashed, mostly due to a lack of an intermediary service that provides guidance and access to climate change scenarios. This perspective presents the concept of a climate change scenario service, its components, and a prototypical implementation to overcome this shortcoming aiming to make scenarios accessible to a broader audience of societal actors and decision makers.

Published
2021

10. Innovations for Sustainability. Pathways to an efficient and post-pandemic future : Report prepared by The World in 2050

Author

Grubler, A., Leininger, Julia, Zimm, C., Clarke, G., Ebi, K., Messner, D., Rockstrom, J., Van Der Leeuw, S., Wilson, C., Zusman, E., Sachs, J., Aguiar, A.P., Al Khourdajie, A., Arent, D., Arimoto, T., Bhowmik, A., Boza-Kiss, B., Breur, A., Carlsen, H., Carrero-Martinez, F., Stancova, K.C., Chabay, I., Chao, C.-W., Colglazier, W.E., Collste, D., Comolli, L., Chou, K.-T., Gadelha, P., Galvao, L.A., Garret, B., Hernandez, Ariel, Iizuka, M., Kanehira, N., Kriegler, E., Kamei, M., Linnerooth-Bayer, J., Lotze-Campen, H., Matusiak, M., Messerli, P., Miller, J., Millward-Hopkins, J., Muttarak, R., Ngerng, R., Obersteiner, M., Oswald, Y., Oyamada, K., Pachauri, S., De Sousa, R.P., Rainoldi, A., Rao, N., Riahi, K., Roehrl, A., Saheb, Y., Schmidt, J., Schmidt-Traub, G., Stabeli, R.G., Steinberger, J., Svedin, U., Suzuki, I., Tilmes, K., Ullah, F., Van Vuuren, D., Visbeck, M., Wingens, C., and Yamada, H.

Subjects
Politikwissenschaft, Soziologie, Sozialwissenschaften
Published
2020

11. The instrument suite of the European Spallation Source

Author

Andersen, K. H., Argyriou, D. N., Jackson, A. J., Houston, J., Henry, P. F., Deen, P. P., Toft-Petersen, R., Beran, P., Strobl, M., Arnold, T., Wacklin-Knecht, H., Tsapatsaris, N., Oksanen, E., Woracek, R., Schweika, W., Mannix, D., Hiess, A., Kennedy, S., Kirstein, O., Petersson Årsköld, S., Taylor, J., Hagen, M. E., Laszlo, G., Kanaki, K., Piscitelli, F., Khaplanov, A., Stefanescu, I., Kittelmann, Th, Pfeiffer, D., Olsson, M., Bordallo, H. N., Vickery, A., Fedrigo, A., Rodrigues, S., Lerche, M., Schulz, M., Müller, M., Carlsen, H., Udby, L., Lefmann, K., Birk, J. O., Holm-Dahlin, S., Bertelsen, M., Hansen, U. Bengaard, Olsen, M. A., Christensen, M., Iversen, K., Christensen, N. B., Rønnow, H. M., Chowdhury, M., Andersen, K. H., Argyriou, D. N., Jackson, A. J., Houston, J., Henry, P. F., Deen, P. P., Toft-Petersen, R., Beran, P., Strobl, M., Arnold, T., Wacklin-Knecht, H., Tsapatsaris, N., Oksanen, E., Woracek, R., Schweika, W., Mannix, D., Hiess, A., Kennedy, S., Kirstein, O., Petersson Årsköld, S., Taylor, J., Hagen, M. E., Laszlo, G., Kanaki, K., Piscitelli, F., Khaplanov, A., Stefanescu, I., Kittelmann, Th, Pfeiffer, D., Olsson, M., Bordallo, H. N., Vickery, A., Fedrigo, A., Rodrigues, S., Lerche, M., Schulz, M., Müller, M., Carlsen, H., Udby, L., Lefmann, K., Birk, J. O., Holm-Dahlin, S., Bertelsen, M., Hansen, U. Bengaard, Olsen, M. A., Christensen, M., Iversen, K., Christensen, N. B., Rønnow, H. M., and Chowdhury, M.

Abstract

An overview is provided of the 15 neutron beam instruments making up the initial instrument suite of the European Spallation Source (ESS), and being made available to the neutron user community. The ESS neutron source consists of a high-power accelerator and target station, providing a unique long-pulse time structure of slow neutrons. The design considerations behind the time structure, moderator geometry and instrument layout are presented. The 15-instrument suite consists of two small-angle instruments, two reflectometers, an imaging beamline, two single-crystal diffractometers; one for macromolecular crystallography and one for magnetism, two powder diffractometers, and an engineering diffractometer, as well as an array of five inelastic instruments comprising two chopper spectrometers, an inverse-geometry single-crystal excitations spectrometer, an instrument for vibrational spectroscopy and a high-resolution backscattering spectrometer. The conceptual design, performance and scientific drivers of each of these instruments are described. All of the instruments are designed to provide breakthrough new scientific capability, not currently available at existing facilities, building on the inherent strengths of the ESS long-pulse neutron source of high flux, flexible resolution and large bandwidth. Each of them is predicted to provide world-leading performance at an accelerator power of 2 MW. This technical capability translates into a very broad range of scientific capabilities. The composition of the instrument suite has been chosen to maximise the breadth and depth of the scientific impact of the early years of the ESS, and provide a solid base for completion and further expansion of the facility.

Published
2020

12. The importance of stakeholders in scoping risk assessments—Lessons from low-carbon transitions

Author

van Vliet, O., Hanger-Kopp, S., Nikas, A., Spijker, E., Carlsen, H., Doukas, H., Lieu, J., van Vliet, O., Hanger-Kopp, S., Nikas, A., Spijker, E., Carlsen, H., Doukas, H., and Lieu, J.

Abstract

Identifying the risks that could impact a low-carbon transition is a prerequisite to assessing and managing these risks. We systematically characterise risks associated with decarbonisation pathways in fifteen case studies conducted in twelve countries around the world. We find that stakeholders from business, government, NGOs, and others supplied some 40 % of these risk inputs, significantly widening the scope of risks considered by academics and experts. Overall, experts and academics consider more economic risks and assess these with quantitative methods and models, while other stakeholders consider political risks more. To avoid losing sight of risks that cannot be easily quantified and modelled, including some economic risks, impact assessment modelling should be complemented with qualitative research and active stakeholder engagement. A systematic risk elicitation facilitates communication with stakeholders, enables better risk mitigation, and increases the chance of a sustainable transition.

Published
2020

13. The instrument suite of the European Spallation Source

Author

Swedish Research Council, Centre National de la Recherche Scientifique (France), Science and Technology Facilities Council (UK), European Commission, Andersen, K. H., Argyriou, D. N., Jackson, A. J., Houston, J., Henry, P. F., Deen, P. P., Toft-Petersen, R., Beran, P., Strobl, M., Arnold, T., Wacklin-Knecht, H., Tsapatsaris, N., Morgano, M., Schefer, J., Filges, U., Klauser, Ch., Niedermayer, Ch., Fenske, J., Nowak, G., Rouijaa, M., Siemers, D. J., Hagen, M. E., Kiehn, R., Oksanen, E., Müller, M., Carlsen, H., Udby, L., Lefmann, K., Birk, J. O., Holm-Dahlin, S., Bertelsen, M., Bengaard Hansen, U., Laszlo, G., Olsen, M. A., Christensen, M., Woracek, R., Iversen, K., Christensen, N. B., Rønnow, H. M., Freeman, P. G., Hauback, B. C., Kolevatov, R., Llamas-Jansa, I., Kanaki, K., Orecchini, A., Sacchetti, F., Petrillo, C., Schweika, W., Paciaroni, A., Tozzi, P., Zanatta, M., Luna, P., Herranz, I., Moral, O. G. del, Piscitelli, F., Huerta, M., Magán, M., Mosconi, M., Abad, E., Mannix, D., Aguilar, J., Stepanyan, S., Bakedano, G., Vivanco, R., Bustinduy, I., Khaplanov, A., Sordo, F., Martínez, J. L., Lechner, R. E., Villacorta, F. J., Šaroun, J., Hiess, A., Lukáš, P., Markó, M., Zanetti, M., Bellissima, S., Stefanescu, I., Rosso, L. del, Masi, F., Bovo, C., Chowdhury, M., De Bonis, A., Di Fresco, L., Kennedy, S., Scatigno, C., Parker, S. F., Fernández-Alonso, Félix, Kittelmann, Th., Colognesi, D., Senesi, R., Andreani, C., Gorini, G., Sciont, G., Schreyer, A., Kirstein, O., Petersson Årsköld, S., Taylor, J., Pfeiffer, D., Hall-Wilton, R., Lopez, C. I., Seifert, M., Aprigliano, G., Whitelegg, L., Moreira, F. Y., Olsson, M., Bordallo, Heloisa N., Martín-Rodríguez, D., Schneider, H., Sharp, M., Hartl, M., Nagy, G., Lohstroh, W., Ansell, S., Pullen, S., Vickery, A., Fedrigo, A., Mezei, F., Arai, M., Heenan, R. K., Halcrow, W., Turner, D., Raspino, D., Petry, W., Orszulik, A., Cooper, J., Webb, N., Galsworthy, P., Nightingale, J., Langridge, S., Elmer, J., Frielinghaus, H., Hanslik, R., Gussen, A., Neuhaus, J., Jaksch, S., Engels, R., Kozielewski, T., Butterweck, S., Feygenson, M., Harbott, P., Poqué, A., Schwaab, A., Lieutenant, K., Violini, N., Loaiza, L., Voigt, J., Brückel, Thomas, Koenen, M., Kämmerling, H., Babcock, E., Salhi, Z., Wischnewski, A., Heynen, A., Désert, S., Jestin, J., Tartaglione, A., Porcher, F., Fabrèges, X., Fabrèges, G., Annighöfer, B., Klimko, S., Dupont, Th., Robillard, Th., Goukassov, A., Longeville, S., Alba-Simionesco, Ch., Glavic, Artur G., Bourges, Ph., Guyon Le Bouffy, J., Lavie, P., Rodrigues, S., Calzada, E., Lerche, M., Schillinger, B., Schmakat, Ph., Schulz, M., Schütz, S., Stahn, J., Lehmann, E., Swedish Research Council, Centre National de la Recherche Scientifique (France), Science and Technology Facilities Council (UK), European Commission, Andersen, K. H., Argyriou, D. N., Jackson, A. J., Houston, J., Henry, P. F., Deen, P. P., Toft-Petersen, R., Beran, P., Strobl, M., Arnold, T., Wacklin-Knecht, H., Tsapatsaris, N., Morgano, M., Schefer, J., Filges, U., Klauser, Ch., Niedermayer, Ch., Fenske, J., Nowak, G., Rouijaa, M., Siemers, D. J., Hagen, M. E., Kiehn, R., Oksanen, E., Müller, M., Carlsen, H., Udby, L., Lefmann, K., Birk, J. O., Holm-Dahlin, S., Bertelsen, M., Bengaard Hansen, U., Laszlo, G., Olsen, M. A., Christensen, M., Woracek, R., Iversen, K., Christensen, N. B., Rønnow, H. M., Freeman, P. G., Hauback, B. C., Kolevatov, R., Llamas-Jansa, I., Kanaki, K., Orecchini, A., Sacchetti, F., Petrillo, C., Schweika, W., Paciaroni, A., Tozzi, P., Zanatta, M., Luna, P., Herranz, I., Moral, O. G. del, Piscitelli, F., Huerta, M., Magán, M., Mosconi, M., Abad, E., Mannix, D., Aguilar, J., Stepanyan, S., Bakedano, G., Vivanco, R., Bustinduy, I., Khaplanov, A., Sordo, F., Martínez, J. L., Lechner, R. E., Villacorta, F. J., Šaroun, J., Hiess, A., Lukáš, P., Markó, M., Zanetti, M., Bellissima, S., Stefanescu, I., Rosso, L. del, Masi, F., Bovo, C., Chowdhury, M., De Bonis, A., Di Fresco, L., Kennedy, S., Scatigno, C., Parker, S. F., Fernández-Alonso, Félix, Kittelmann, Th., Colognesi, D., Senesi, R., Andreani, C., Gorini, G., Sciont, G., Schreyer, A., Kirstein, O., Petersson Årsköld, S., Taylor, J., Pfeiffer, D., Hall-Wilton, R., Lopez, C. I., Seifert, M., Aprigliano, G., Whitelegg, L., Moreira, F. Y., Olsson, M., Bordallo, Heloisa N., Martín-Rodríguez, D., Schneider, H., Sharp, M., Hartl, M., Nagy, G., Lohstroh, W., Ansell, S., Pullen, S., Vickery, A., Fedrigo, A., Mezei, F., Arai, M., Heenan, R. K., Halcrow, W., Turner, D., Raspino, D., Petry, W., Orszulik, A., Cooper, J., Webb, N., Galsworthy, P., Nightingale, J., Langridge, S., Elmer, J., Frielinghaus, H., Hanslik, R., Gussen, A., Neuhaus, J., Jaksch, S., Engels, R., Kozielewski, T., Butterweck, S., Feygenson, M., Harbott, P., Poqué, A., Schwaab, A., Lieutenant, K., Violini, N., Loaiza, L., Voigt, J., Brückel, Thomas, Koenen, M., Kämmerling, H., Babcock, E., Salhi, Z., Wischnewski, A., Heynen, A., Désert, S., Jestin, J., Tartaglione, A., Porcher, F., Fabrèges, X., Fabrèges, G., Annighöfer, B., Klimko, S., Dupont, Th., Robillard, Th., Goukassov, A., Longeville, S., Alba-Simionesco, Ch., Glavic, Artur G., Bourges, Ph., Guyon Le Bouffy, J., Lavie, P., Rodrigues, S., Calzada, E., Lerche, M., Schillinger, B., Schmakat, Ph., Schulz, M., Schütz, S., Stahn, J., and Lehmann, E.

Abstract

An overview is provided of the 15 neutron beam instruments making up the initial instrument suite of the European Spallation Source (ESS), and being made available to the neutron user community. The ESS neutron source consists of a high-power accelerator and target station, providing a unique long-pulse time structure of slow neutrons. The design considerations behind the time structure, moderator geometry and instrument layout are presented. The 15-instrument suite consists of two small-angle instruments, two reflectometers, an imaging beamline, two single-crystal diffractometers; one for macromolecular crystallography and one for magnetism, two powder diffractometers, and an engineering diffractometer, as well as an array of five inelastic instruments comprising two chopper spectrometers, an inverse-geometry single-crystal excitations spectrometer, an instrument for vibrational spectroscopy and a high-resolution backscattering spectrometer. The conceptual design, performance and scientific drivers of each of these instruments are described. All of the instruments are designed to provide breakthrough new scientific capability, not currently available at existing facilities, building on the inherent strengths of the ESS long-pulse neutron source of high flux, flexible resolution and large bandwidth. Each of them is predicted to provide world-leading performance at an accelerator power of 2 MW. This technical capability translates into a very broad range of scientific capabilities. The composition of the instrument suite has been chosen to maximise the breadth and depth of the scientific impact of the early years of the ESS, and provide a solid base for completion and further expansion of the facility.

Published
2020

14. UCANS-8 in Paris Eighth International Meeting of the Union for Compact Accelerator-Driven Neutron Sources

Author

Ott, Frédéric, Menelle, Alain, Alba-Simionesco, Christiane, Andersen, K.H., Argyriou, D.N, Jackson, A.J., Houston, J., Henry, P.F., Deen, P.P., Toft-Petersen, R., Beran, P., Strobl, M., Arnold, T., Wacklin-Knecht, H., Tsapatsaris, N., Oksanen, E., Woracek, R., Schweika, W., Mannix, D., Hiess, A., Kennedy, S., Kirstein, O., Petersson Årsköld, S., Taylor, J., Hagen, M.E., Laszlo, G., Kanaki, K., Piscitelli, F., Khaplanov, A., Stefanescu, I., Kittelmann, Th., Pfeiffer, D., Hall-Wilton, R., Lopez, C.I., Aprigliano, G., Whitelegg, L., Moreira, F.Y., Olsson, M., Bordallo, H.N., Martín-Rodríguez, D., Schneider, Henri, Sharp, M., Hartl, M., Nagy, G., Ansell, S., Pullen, S., Vickery, A., Fedrigo, A., Mezei, F., Arai, M., Heenan, R.K., Halcrow, W., Turner, D., Raspino, D., Orszulik, A., Cooper, J., Webb, N., Galsworthy, P., Nightingale, J., Langridge, S., Elmer, J., Frielinghaus, H., Hanslik, R., Gussen, A., Jaksch, S., Engels, R., Kozielewski, T., Butterweck, S., Feygenson, M., Harbott, P., Poqué, A., Schwaab, A., Lieutenant, K., Violini, N., Voigt, J., Brückel, T., Koenen, M., Kämmerling, H., Babcock, E., Salhi, Z., Wischnewski, A., Heynen, A., Désert, S., Jestin, J., Porcher, F., Fabrèges, Xavier, Fabrèges, G., Annighöfer, B., Klimko, S., Dupont, Th., Robillard, Th., Goukassov, A., Longeville, S., Alba-Simionesco, Ch., Bourges, Ph., Guyon Le Bouffy, J., Lavie, P., Rodrigues, S., Calzada, E., Lerche, M., Schillinger, B., Schmakat, Ph., Schulz, M., Seifert, M., Lohstroh, W., Petry, W., Neuhaus, J., Loaiza, L., Tartaglione, A., Glavic, A., Schütz, S., Stahn, J., Lehmann, E., Morgano, M., Schefer, J., Filges, U., Klauser, Ch., Niedermayer, Ch., Fenske, J., Nowak, G., Rouijaa, M., Siemers, D.J., Kiehn, R., Müller, M., Carlsen, H., Udby, L., Lefmann, K., Birk, J.O., Holm-Dahlin, S., Bertelsen, M., Hansen, U. Bengaard, Olsen, M.A., Christensen, M., Iversen, K., Christensen, N.B., Rønnow, H.M., Freeman, P.G., Hauback, B.C., Kolevatov, R., Llamas-Jansa, I., Orecchini, A., Sacchetti, F., Petrillo, C., Paciaroni, A., Tozzi, P., Zanatta, M., Luna, P., Herranz, I., del Moral, O.G., Huerta, M., Magán, M., Mosconi, M., Abad, E., Aguilar, J., Stepanyan, S., Bakedano, G., Vivanco, R., Bustinduy, I., Sordo, F., Martínez, J.L., Lechner, R.E., Villacorta, F.J., Šaroun, J., Lukáš, P., Markó, M., Zanetti, M., Bellissima, S., del Rosso, L., Masi, F., Bovo, C., Chowdhury, M., de Bonis, A., Di Fresco, L., Scatigno, C., Parker, S.F., Fernandez-Alonso, F., Colognesi, D., Senesi, R., Andreani, C., Gorini, G., Scionti, G., Schreyer, A., Laboratoire Léon Brillouin (LLB - UMR 12), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, 010308 nuclear & particles physics, Political science, 0103 physical sciences, Library science, Neutron source, [CHIM.MATE]Chemical Sciences/Material chemistry, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], 010306 general physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, ComputingMilieux_MISCELLANEOUS, Dozen
Abstract

The 8th international meeting of the Union for Compact Accelerator-Driven Neutron Sources (UCANS-8) was held in Paris, July 8–11, 2019. Over 140 participants from more than a dozen countries from v...

Published
2019

19. Potential applications of subseasonal-to-seasonal (S2S) predictions

Author

White, CJ, Carlsen, H, Robertson, AW, Klein, RJT, Lazo, JK, Kumar, A, Vitart, F, de Perez, E, Ray, AJ, Murray, V, Bharwani, S, MacLeod, D, James, R, Fleming, L, Morse, AP, Eggen, B, Graham, R, Kjellström, E, Becker, E, Pegion, KV, Holbrook, NJ, McEvoy, D, Depledge, M, Perkins-Kirkpatrick, S, Brown, TJ, Street, R, Jones, L, Remenyi, TA, Hodgson-Johnston, I, Buontempo, C, Lamb, R, Meinke, H, Arheimer, B, Zebiak, SE, and Water and Climate Risk

Subjects
SDG 13 - Climate Action
Abstract

While seasonal outlooks have been operational for many years, until recently the extended-range timescale referred to as subseasonal-to-seasonal (S2S) has received little attention. S2S prediction fills the gap between short-range weather prediction and long-range seasonal outlooks. Decisions in a range of sectors are made in this extended-range lead time; therefore, there is a strong demand for this new generation of forecasts. International efforts are under way to identify key sources of predictability, improve forecast skill and operationalize aspects of S2S forecasts; however, challenges remain in advancing this new frontier. If S2S predictions are to be used effectively, it is important that, along with science advances, an effort is made to develop, communicate and apply these forecasts appropriately. In this study, the emerging operational S2S forecasts are presented to the wider weather and climate applications community by undertaking the first comprehensive review of sectoral applications of S2S predictions, including public health, disaster preparedness, water management, energy and agriculture. The value of applications-relevant S2S predictions is explored, and the opportunities and challenges facing their uptake are highlighted. It is shown how social sciences can be integrated with S2S development, from communication to decision-making and valuation of forecasts, to enhance the benefits of ‘climate services’ approaches for extended-range forecasting. While S2S forecasting is at a relatively early stage of development, it is concluded that it presents a significant new window of opportunity that can be explored for application-ready capabilities that could allow many sectors the opportunity to systematically plan on a new time horizon.

Published
2017

23. Choosing small sets of policy-relevant scenarios by combining vulnerability and diversity approaches

Author

Carlsen, H., Lempert, R., Wikman-Svahn, Per, Schweizer, V., Carlsen, H., Lempert, R., Wikman-Svahn, Per, and Schweizer, V.

Abstract

Computer simulation models can generate large numbers of scenarios, far more than can be effectively utilized in most decision support applications. How can one best select a small number of scenarios to consider? One approach calls for choosing scenarios that illuminate vulnerabilities of proposed policies. Another calls for choosing scenarios that span a diverse range of futures. This paper joins these two approaches for the first time, proposing an optimization-based method for choosing a small number of relevant scenarios that combine both vulnerability and diversity. The paper applies the method to a real case involving climate resilient infrastructure for three African river basins (Volta, Orange and Zambezi). Introducing selection criteria in a stepwise manner helps examine how different criteria influence the choice of scenarios. The results suggest that combining vulnerability- and diversity-based criteria can provide a systematic and transparent method for scenario selection., QC 20161111

Published
2016
Full Text
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24. Sports and Allergies

Author

BONINI, Sergio, Carlsen H. K, Del Giacco S, Storms W., Bonini, Sergio, Carlsen, H. K., Del Giacco, S, and Storms, W.

Published
2009

26. CO2 Neutral, Low Emission Small Scale Biomass CHP Plants Based on Updraft Gasification and Stirling Engines - Technology Development

Author

Marinitsch, G., Bovin, J., Gørtz, T., Mygind, K., and Carlsen, H.

Subjects
Biomass
Abstract

The biomass CHP technology based on updraft gasification and Stirling engines enables the production of high value electricity and heat in an efficient way in applications below 300­500 kWe electric power output. Thus, a technology gap for the electricity production is filled for carbon neutral small scale CHP plants. The technology is currently entering the market with the first commercial installations in Denmark, Germany and the UK. In this paper, a detailed evaluation on the thermodynamic potential, limits and existing boundary conditions for the optimization of the overall electrical plant efficiency on such a plant is presented. The technology also has the benefit of achieving low emission levels especially with regards to particle emissions. This is an important feature since it is usually difficult to meet low emissions on small scale plants, because the possibilities for implementing primary and secondary measures to keep the emissions on a low level is limited. The paper presents the findings from detailed emission measurements performed., Proceedings of the 19th European Biomass Conference and Exhibition, 6-10 June 2011, Berlin, Germany, pp. 981-990

Published
2011
Full Text
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28. Bygherrekrav - Digital Aflevering:kravspecifikation - revision 2

Author

Sabroe, H., Johansen, J., Fage, N., Christensen, L., Buchardt, L., Emborg, J., Christiansson, Per, Carlsen, H., and Jensen, P.A.

Subjects
Krav, Digital aflevering, Datamodel, Kravsspecifikation, Byggherre, Aflevering, Vejledning
Abstract

Nærværende kravspecifikation er bygherrens krav til digital aflevering. Kravspecifikationens mål er at beskrive form, indhold og omfang af de digitale data, som bygherren skal modtage ved projektets afslutning. Kravspecifikationen anvendes som et udbuds- og kontraktdokument med tilføjelse af projektspecifikke oplysninger og valg. Nærværende kravspecifikation er bygherrens krav til digital aflevering. Kravspecifikationens mål er at beskrive form, indhold og omfang af de digitale data, som bygherren skal modtage ved projektets afslutning. Kravspecifikationen anvendes som et udbuds- og kontraktdokument med tilføjelse af projektspecifikke oplysninger og valg.

Published
2006

29. Bygherrekrav - Digital Aflevering:Vejledning til kravspecifikation - revision 2 : DACaPo

Author

Sabroe, H., Johansen, J., Fage, N., Christensen, L., Buchardt, L., Emborg, J., Christiansson, Per, Carlsen, H., and Jensen, P. A.

Subjects
Datamodel, Byggherre, Aflevering, Vejledning
Abstract

Nærværende vejledning er en uddybning til kravspecifikation for "Digital aflevering". Kravspecifikationen omfatter bygherres/driftsherres krav til digital aflevering. Vejledningen er for både bygherre/driftsherre, der skal foretage valg, og for projekterende/udførende, der skal efterleve krav. De steder, hvor der er afvigelser fra om man er bygherre/driftsherre eller projekterende/udførende, opdeles vejledningen i 2 kolonner.Alle emner er direkte relateret til kravspecifikationens emner

Published
2006

31. Bygherrekrav - Digital Aflevering:Vejledning til kravspecifikation - revision 1

Author

Sabroe, H., Johansen, J., Fage, N., Christensen, L., Buchardt, L., Emborg, J., Christiansson, Per, Carlsen, H., and Jensen, P.A.

Subjects
Krav, Digital aflevering, Datamodel, Kravsspecifikation, Byggherre, Aflevering, Vejledning
Abstract

Nærværende vejledning er en uddybning til kravspecifikation for "Digital aflevering". Kravspecifikationen omfatter bygherres/driftsherres krav til digital aflevering. Vejledningen er for både bygherre/driftsherre, der skal foretage valg, og for projekterende/udførende, der skal efterleve krav. De steder, hvor der er afvigelser fra om man er bygherre/driftsherre eller projekterende/udførende, opdeles vejledningen i 2 kolonner.

Published
2005

33. DACaPo Digital Handover - Booklet

Author

Christiansson, Per Lennart, Fage, N., Jensen, P.A., Johansen, J., and Carlsen, H.

Subjects
Krav, Datamodel, Bygherre, Aflevering
Published
2005

36. Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics

Author

Farstad, I N, Carlsen, H, Morton, H C, and Brandtzaeg, P

Subjects
Adult, Adolescent, Lymphoid Tissue, B-Lymphocyte Subsets, chemical and pharmacologic phenomena, hemic and immune systems, Original Articles, Middle Aged, Flow Cytometry, Immunophenotyping, Peyer's Patches, Immunoglobulin M, Child, Preschool, Immunoglobulin A, Secretory, Intestine, Small, Humans, CD40 Antigens, Intestinal Mucosa, Child, Immunity, Mucosal, Cell Division, Aged
Abstract

We compared B-cell phenotypes in Peyer's patches and solitary lymphoid follicles (organized gut-associated lymphoid tissue, GALT) with those in jejunal or ileal lamina propria. In situ, immunostaining showed that small B cells of naive [surface immunoglobulin D-positive (sIgD+) CD27-] and memory (sIgD+/- CD27+) phenotypes occurred almost exclusively in GALT, whereas the lamina propria contained only scattered sIgA+ CD27+ memory cells. In contrast, B-cell blasts and plasma cells negative for CD20 and often also for CD19 but with strong expression of CD38, CD27 and cytoplasmic IgA (cIgA), dominated in the lamina propria but were scarce in GALT. By flow cytometry, the proportion of dispersed CD19+ B lymphocytes varied from 4 to 42% among jejunal mucosal samples; between 5 and 50% of these were sIgD+, suggesting a variable contamination with GALT cells. B-cell blasts and plasma cells, identified by their large size and strong expression of CD38, were regularly found (25-35% of the total mononuclear cell population). Distinction between B-cell blasts and mature plasma cells was made by the presence or absence of human leucocyte antigen (HLA) class II molecules, CD45RA, CD19 and surface immunoglobulin. No CD19+ B cells outside GALT expressed CD5, but a very small portion of the lamina propria B-cell blasts were positive for CD28. Dispersed sIgA+ lamina propria cells expressed low levels of CD40, proliferated on CD40 ligation and constitutively secreted IgA in vitro. We concluded that the lamina propria B-cell compartment consists mainly of B-cell blasts and plasma cells but also has scattered, small sIgA+ cells that can proliferate in response to CD40 ligation and may therefore function as local memory cells for recall antigens.

Published
2000

37. Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior

Author

Lauritzen, K H, Moldestad, O, Eide, L, Carlsen, H, Nesse, G, Storm, J, Mansuy, I M, Bergersen, L H, Klungland, A, Lauritzen, K H, Moldestad, O, Eide, L, Carlsen, H, Nesse, G, Storm, J, Mansuy, I M, Bergersen, L H, and Klungland, A

Abstract

Mitochondrial dysfunction underlying changes in neurodegenerative diseases is often associated with apoptosis and a progressive loss of neurons, and damage to the mitochondrial genome is proposed to be involved in such pathologies. In the present study we designed a mouse model that allows us to specifically induce mitochondrial DNA toxicity in the forebrain neurons of adult mice. This is achieved by CaMKIIalpha-regulated inducible expression of a mutated version of the mitochondrial UNG DNA repair enzyme (mutUNG1). This enzyme is capable of removing thymine from the mitochondrial genome. We demonstrate that a continual generation of apyrimidinic sites causes apoptosis and neuronal death. These defects are associated with behavioral alterations characterized by increased locomotor activity, impaired cognitive abilities, and lack of anxietylike responses. In summary, whereas mitochondrial base substitution and deletions previously have been shown to correlate with premature and natural aging, respectively, we show that a high level of apyrimidinic sites lead to mitochondrial DNA cytotoxicity, which causes apoptosis, followed by neurodegeneration.

Published
2010

40. Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist.

Author

Smeets, R.L.L., Joosten, L.A.B., Arntz, O.J., Bennink, M.B., Takahashi, N., Carlsen, H., Martin, M.U., Berg, W.B. van den, Loo, F.A.J. van de, Smeets, R.L.L., Joosten, L.A.B., Arntz, O.J., Bennink, M.B., Takahashi, N., Carlsen, H., Martin, M.U., Berg, W.B. van den, and Loo, F.A.J. van de

Abstract

Contains fulltext : 47344.pdf (publisher's version ) (Closed access), OBJECTIVE: To discern the mode of interleukin-1 (IL-1) inhibition of soluble IL-1 receptor accessory protein (sIL-1RAcP) by comparison with IL-1 receptor antagonist (IL-1Ra) in arthritis. METHODS: Adenoviral vectors encoding either sIL-1RAcP or IL-1Ra were administered systemically before onset of collagen-induced arthritis in DBA/1 mice. Anti-bovine type II collagen IgG and IL-6 were quantified in serum. Proliferative response of splenic T cells was determined in the presence of sIL-1RAcP or IL-1Ra. The effect on IL-1 inhibition of recombinant sIL-1RAcP and IL-1Ra was further examined in vitro, using NF-kappaB luciferase reporter cell lines. Quantitative polymerase chain reaction was used to determine the relative messenger RNA expression of the IL-1 receptors. RESULTS: Adenoviral overexpression of both sIL-1RAcP and IL-1Ra resulted in amelioration of the collagen-induced arthritis. Both IL-1 antagonists reduced the circulating levels of antigen-specific IgG2a antibodies, but only IL-1Ra was able to inhibit lymphocyte proliferation. By using purified lymphocyte populations derived from NF-kappaB reporter mice, we showed that sIL-1RAcP inhibits IL-1-induced NF-kappaB activity in B cells but not T cells, whereas IL-1Ra inhibited IL-1 on both cell types. A study in a panel of NF-kappaB luciferase reporter cells showed that the sIL-1RAcP inhibits IL-1 signaling on cells expressing either low levels of membrane IL-1RAcP or high levels of IL-1RII. CONCLUSION: We show that the sIL-1RAcP ameliorated experimental arthritis without affecting T cell immunity, in contrast to IL-1Ra. Our results provide data in support of receptor competition by sIL-1RAcP as an explanation for the different mode of IL-1 antagonism in comparison with IL-1Ra.

Published
2005

46. Dynamics of particles for circular Rydberg states

Author

Carlsen, H, Goscinski, O, Carlsen, H, and Goscinski, O

Abstract

The dynamics of circular Rydberg wave packets for the hydrogen atom with particular emphasis on fractional and full revivals previously studied by Gaeta and Stroud [Phys. Rev. A 42, 6308 (1990)], is developed within the de Broglie-Bohm pilot-wave theory., Carlsen H, Univ Uppsala, Dept Quantum Chem, Box 518, S-75120 Uppsala, Sweden. Univ Uppsala, Dept Quantum Chem, S-75120 Uppsala, Sweden.

Published
1999

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