24 results on '"Carlotta Zanaboni Dina"'
Search Results
2. Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles
- Author
-
Matteo Briguglio, Silvana Hrelia, Marco Malaguti, Loredana Serpe, Roberto Canaparo, Bernardo Dell’Osso, Roberta Galentino, Sara De Michele, Carlotta Zanaboni Dina, Mauro Porta, and Giuseppe Banfi
- Subjects
food-drug interactions ,herb-drug interactions ,pharmacologic processes ,dietary supplements ,nutraceutical ,precision medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Preclinical and clinical studies suggest that many food molecules could interact with drug transporters and metabolizing enzymes through different mechanisms, which are predictive of what would be observed clinically. Given the recent incorporation of dietary modifications or supplements in traditional medicine, an increase in potential food-drug interactions has also appeared. The objective of this article is to review data regarding the influence of food on drug efficacy. Data from Google Scholar, PubMed, and Scopus databases was reviewed for publications on pharmaceutical, pharmacokinetic, and pharmacodynamic mechanisms. The following online resources were used to integrate functional and bioinformatic results: FooDB, Phenol-Explorer, Dr. Duke's Phytochemical and Ethnobotanical Databases, DrugBank, UniProt, and IUPHAR/BPS Guide to Pharmacology. A wide range of food compounds were shown to interact with proteins involved in drug pharmacokinetic/pharmacodynamic profiles, starting from drug oral bioavailability to enteric/hepatic transport and metabolism, blood transport, and systemic transport/metabolism. Knowledge of any food components that may interfere with drug efficacy is essential, and would provide a link for obtaining a holistic view for cancer, cardiovascular, musculoskeletal, or neurological therapies. However, preclinical interaction may be irrelevant to clinical interaction, and health professionals should be aware of the limitations if they intend to optimize the therapeutic effects of drugs.
- Published
- 2018
- Full Text
- View/download PDF
3. Dietary Neurotransmitters: A Narrative Review on Current Knowledge
- Author
-
Matteo Briguglio, Bernardo Dell’Osso, Giancarlo Panzica, Antonio Malgaroli, Giuseppe Banfi, Carlotta Zanaboni Dina, Roberta Galentino, and Mauro Porta
- Subjects
functional foods ,neurotransmitters ,diet, food, and nutrition ,acetylcholine ,glutamate ,gamma-aminobutyric acid ,dopamine ,serotonin ,histamine ,gut microbiota ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs. Relevant books and literature from PubMed and Scopus databases were searched for data on food sources of Ach, glutamate, GABA, dopamine, 5-HT, and histamine. Different animal foods, fruits, edible plants, roots, and botanicals were reported to contain NTs. These substances can either be naturally present, as part of essential metabolic processes and ecological interactions, or derive from controlled/uncontrolled food technology processes. Ripening time, methods of preservation and cooking, and microbial activity further contributes to NTs. Moreover, gut microbiota are considerable sources of NTs. However, the significance of dietary NTs intake needs to be further investigated as there are no significant data on their bioavailability, neuronal/non neuronal effects, or clinical implications. Evidence-based interventions studies should be encouraged.
- Published
- 2018
- Full Text
- View/download PDF
4. Creativity Assessment in Subjects with Tourette Syndrome vs. Patients with Parkinson’s Disease: A Preliminary Study
- Author
-
Carlotta Zanaboni Dina, Mauro Porta, Christian Saleh, and Domenico Servello
- Subjects
creativity ,tic ,Tourette syndrome ,Parkinson disease ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
(1) Background: Literature suggests that high levels of dopamine are associated with creative thoughts. Tourette Syndrome (TS) patients have high dopamine levels, while Parkinson’s Disease (PD) subjects have low dopamine levels. Consequently, TS individuals are supposed to have a major and PD patients less creative output. Moreover, dopamine medications may alter the level of creativity, and therefore Quality of Life, in both pathologies. (2) Methods: The aim of the study was to verify the hypothesis of TS patients having higher creative scores than PD patients. The assessment consisted of the administration of the Creative Thinking ASK Test. There were 54 participants—36 males and 18 females—i.e., 27 TS patients and 27 PD subjects. Age of the sample was 35 to 57 years old, high school certificate was required. (3) Results: TS sample (103.11 ASK average score) was more creative than PD sample (94.11 ASK average score). (4) Conclusions: The results supported the aforementioned hypothesis: TS sample resulted in having higher creative scores than PD sample. Dopamine and other neurotransmitters of TS and PS appear to affect subject’s creativity. Further studies with creative assessments in TS and PD patients are needed to support the preliminary results of our study.
- Published
- 2017
- Full Text
- View/download PDF
5. Obsessive Compulsive Tic Disorder: appropriate diagnosis and treatment as key elements to improve health and rationalize use of resources
- Author
-
Mauro Porta, Lucia Sara D'Angiolella, Domenico Servello, Roberta Galentino, Luciana Scalone, Lorenzo G. Mantovani, Carlotta Zanaboni Dina, Bernardo Dell'Osso, Scalone, L, D’Angiolella, L, Mantovani, L, Galentino, R, Servello, D, Dell’Osso, B, Zanaboni Dina, C, and Porta, M
- Subjects
Pediatrics ,medicine.medical_specialty ,Tic disorder ,Obsessive Compulsive Disorder (OCD) ,Deep brain stimulation ,Tic Disorder (TD) ,Tics ,Adult patients ,Cost ,Obsessive Compulsive Tic Disorder (OCTD) ,business.industry ,medicine.medical_treatment ,Social impairment ,medicine.disease ,Head of the Outcomes Research Unit ,Obsessive compulsive ,Endophenotype ,medicine ,business ,Obsessive-compulsive disorder (OCD) ,Early onset - Abstract
Background: Obsessive Compulsive Tic Disorder (OCTD) has been described recently as an early onset and highly disabling endophenotype of Tic Disorder and Obsessive Compulsive Disorder. OCTD has a relevant but largely unknown clinical, social and economic burden for patients and their families. Our paper aimed to explore relevant aspects of the burden of OCTD, such as the etiological, clinical and epidemiological aspects of the condition, and implication of diagnosis and treatment on patients’ health and socio-economic impact. Methods: We conducted a literature review and a pilot study using retrospective demographic, clinical and economic data of patients with OCTD accessing the Galeazzi Hospital in Milan Result: The literature review shows the absence of information on OCTD. From the pilot study we analysed data of 30 patients (80.0% male, 36.7% aged from 7 to 13 years, 63.3% aged from 15 to 48 years), 83.0% declared that obsessions and/or compulsions were the most important factors determining their social impairment. Adult patients refractory to drug treatment underwent Deep Brain Stimulation plus drugs. The mean clinical scores at the time of diagnosis indicated a severe condition for both tics and obsessive compulsive components. The mean time elapsed from symptoms onset to diagnosis of OCTD was 5.6 years, reaching up to 11 years in one case. Before reaching the correct diagnosis, different specialists visited the patients several times, 93.3% underwent diagnostic examinations and 86.7% took 2 or 3 different drugs. Ten patients were hospitalised and 8 had received psychotherapy. Discussion: Albeit preliminary, these results show that attention is mandatory for establishing correct diagnosis and treatment guidelines to improve health and rationally spend resources for OCTD.
- Published
- 2022
6. Healthy Eating, Physical Activity, and Sleep Hygiene (HEPAS) as the Winning Triad for Sustaining Physical and Mental Health in Patients at Risk for or with Neuropsychiatric Disorders: Considerations for Clinical Practice
- Author
-
Mauro Porta, Ira D. Glick, Alberto R. Bona, Roberta Galentino, Carlotta Zanaboni Dina, Jacopo Antonino Vitale, Bernardo Dell'Osso, Matteo Briguglio, Giancarlo Panzica, Giuseppe Banfi, Briguglio, M., Vitale, J. A., Galentino, R., Banfi, G., Dina, C. Z., Bona, A., Panzica, G., Porta, M., Dell'Osso, B., and Glick, I. D.
- Subjects
medicine.medical_specialty ,Neuropsychiatric Disease and Treatment ,education ,Psychological intervention ,Physical activity ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Healthy eating ,Motor activity ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,In patient ,Diet ,Neuropsychiatry ,Quality of health care ,Sleep ,RC346-429 ,Psychiatry ,Sleep hygiene ,business.industry ,Mental health ,030227 psychiatry ,Clinical Practice ,quality of health care ,Neurology. Diseases of the nervous system ,business ,030217 neurology & neurosurgery ,Perspectives ,RC321-571 - Abstract
Matteo Briguglio,1,* Jacopo Antonino Vitale,1 Roberta Galentino,2 Giuseppe Banfi,1,3 Carlotta Zanaboni Dina,4 Alberto Bona,5 Giancarlo Panzica,6 Mauro Porta,2,* Bernardo Dell’Osso,7–9,* Ira David Glick9,* 1IRCCS Orthopedic Institute Galeazzi, Scientific Direction, Milan, Italy; 2IRCCS Orthopedic Institute Galeazzi, Tourette’s Syndrome and Movement Disorders Centre, Milan, Italy; 3Department of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy; 4TICEA Center, Scientific Direction, Milan, Italy; 5Neurosurgery Department, ICCS Istituto Clinico Città Studi, Milan, Italy; 6Department of Neuroscience, Rita Levi Montalcini, University of Turin, Turin, Italy; 7University of Milan, Department of Clinical and Biomedical Sciences Luigi Sacco, ASST Fatebenefratelli-Sacco, Ospedale Sacco Polo Universitario, Milan, Italy; 8“Aldo Ravelli” Center for Neurotechnology and Brain Therapeutic, University of Milan, Milan, Italy; 9Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA*These authors contributed equally to this workCorrespondence: Matteo BriguglioIRCCS Orthopedic Institute Galeazzi, Scientific Direction, Via Riccardo Galeazzi, 4, Milan 20161, MI, ItalyTel +39 338 6087042Email matteo.briguglio@grupposandonato.itAbstract: Neuropsychiatric disorders stem from gene-environment interaction and their development can be, at least in some cases, prevented by the adoption of healthy and protective lifestyles. Once full blown, neuropsychiatric disorders are prevalent conditions that patients live with a great burden of disability. Indeed, the determinants that increase the affliction of neuropsychiatric disorders are various, with unhealthy lifestyles providing a significant contribution in the interplay between genetic, epigenetic, and environmental factors that ultimately represent the pathophysiological basis of these impairing conditions. On one hand, the adoption of Healthy Eating education, Physical Activity programs, and Sleep hygiene promotion (HEPAS) has the potential to become one of the most suitable interventions to reduce the risk to develop neuropsychiatric disorders, while, on the other hand, its integration with pharmacological and psychological therapies seems to be essential in the overall management of neuropsychiatric disorders in order to reduce the disability and improve the quality of life of affected patients. We present an overview of the current evidence in relation to HEPAS components in the prevention and management of neuropsychiatric disorders and provide suggestions for clinical practice.Keywords: neuropsychiatry, diet, motor activity, sleep, quality of health care
- Published
- 2020
7. TOURETTE SYNDROME AND NUTRITIONAL IMPLICATIONS
- Author
-
Carlotta Zanaboni Dina, Matteo Briguglio, Mauro Porta, and Domenico Servello
- Subjects
Pediatrics ,medicine.medical_specialty ,Tics ,business.industry ,Overweight ,medicine.disease ,Dysphagia ,Tourette syndrome ,Discontinuation ,Neurodevelopmental disorder ,Quality of life ,medicine ,Metabolic syndrome ,medicine.symptom ,business - Abstract
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder defined by multiple motor tics and at least one sound tic. Various behavioural symptoms are associated with GTS, especially obsession and compulsion behaviours (OCBs), attention-deficit/hyperactivity disorder (ADHD) and poor impulse control. These comorbid conditions have a high impact on patients quality of life, including eating attitudes and body image perception. Nutritional implications, together with sleepiness and sexual asthenia, are the principal side effects of the pharmacological therapy. Actually, drugs may compromise the nutritional status of patients producing appetite increase, dry mouth, constipation, glucose and lipid metabolism abnormalities, metabolic syndrome, mild transient dysphagia and nausea. About 40% of GTS patients experience hyperphagia because of drug side effects, OCBs, ADHD, or poor impulse control. Consequently, in these cases an overweight status can occur, complicating the management of the symptoms. Therefore, an increase body weight should be considered one of the most relevant factors increasing GTS drug-related bad compliance, which may consequently cause in some patients the discontinuation/interruption of the pharmacological therapy.
- Published
- 2020
8. Music-dance-imaging training for young adults with Tourette Syndrome
- Author
-
Carlotta Zanaboni Dina, Sabrina, Rago, Cancer, Alice, and Antonietti, Alessandro
- Subjects
Dance ,Tic ,Tourette ,Voluntary movement ,Mood ,Training ,Settore M-PSI/01 - PSICOLOGIA GENERALE ,Music Therapy ,Music ,Imaging - Published
- 2020
9. Tourette syndrome and the law∗
- Author
-
Carlotta Zanaboni Dina and Mauro Porta
- Subjects
medicine.medical_specialty ,medicine ,Psychology ,Psychiatry ,medicine.disease ,Tourette syndrome - Published
- 2019
10. Giuseppe and his coughing OCTD∗
- Author
-
Mauro Porta and Carlotta Zanaboni Dina
- Published
- 2019
11. Therapy for Tourette syndrome∗
- Author
-
Carlotta Zanaboni Dina and Mauro Porta
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,business ,medicine.disease ,Tourette syndrome - Published
- 2019
12. The role of school∗
- Author
-
Carlotta Zanaboni Dina and Mauro Porta
- Published
- 2019
13. Diagnosing Tourette syndrome
- Author
-
Carlotta Zanaboni Dina and Mauro Porta
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,business ,medicine.disease ,Tourette syndrome - Published
- 2019
14. A medical overview of Tourette syndrome∗
- Author
-
Carlotta Zanaboni Dina and Mauro Porta
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,business ,medicine.disease ,Tourette syndrome - Published
- 2019
15. The role of family∗
- Author
-
Carlotta Zanaboni Dina and Mauro Porta
- Subjects
Psychology - Published
- 2019
16. A short history of Tourette syndrome*
- Author
-
Carlotta Zanaboni Dina and Mauro Porta
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,medicine ,medicine.disease ,business ,Tourette syndrome - Published
- 2019
17. Friendship and spare time∗
- Author
-
Mauro Porta and Carlotta Zanaboni Dina
- Subjects
Friendship ,media_common.quotation_subject ,Spare time ,Psychology ,Social psychology ,media_common - Published
- 2019
18. Understanding Tourette Syndrome : A Guide to Symptoms, Management and Treatment
- Author
-
Carlotta Zanaboni Dina, Mauro Porta, Carlotta Zanaboni Dina, and Mauro Porta
- Subjects
- Behavior disorders in children, Tourette syndrome in children, Conduct disorders in children
- Abstract
Understanding Tourette Syndrome provides accessible, concise, evidence-based guidelines on this neurodevelopmental disorder, offering parents and professionals a deeper scientific understanding of the condition and its consequences. Zanaboni Dina and Porta explore signs, symptoms and treatment of the disease, with the aim of demonstrating to all those involved in the life of a TS child solutions to manage a range of situations from diagnosis to day-to-day life. Therapies and social intervention, including Habit Reversal Training and Deep Brain Stimulation, are described, allowing caregivers to evaluate the best course of treatment. With a focus on improving quality of life by offering practical recommendations for managing the condition at school and in the family, it places additional emphasis on sibling relationships and the importance of childhood friendship. The authors'expert subject knowledge and extensive experience of working with children and families, makes the topic accessible for any reader, and case studies demonstrate how to apply scientific understanding of the condition to a real-life situation. This unique guide is essential reading for parents and carers, as well as practitioners in Clinical and Educational Psychology, Counselling, Mental Health, Nursing, Child Welfare, Public Healthcare and those in Education. It will also be of interest to postgraduates studying courses in Psychology, Neurology and Psychiatry.
- Published
- 2020
19. Food bioactive compounds and their interference in drug pharmacokinetic/pharmacodynamic profiles
- Author
-
Silvana Hrelia, De Michele S, Bernardo Dell'Osso, Roberta Galentino, Roberto Canaparo, Mauro Porta, Matteo Briguglio, Marco Malaguti, Carlotta Zanaboni Dina, Loredana Serpe, Giuseppe Banfi, Briguglio, Matteo, Hrelia, Silvana, Malaguti, Marco, Serpe, Loredana, Canaparo, Roberto, Dell’Osso, Bernardo, Galentino, Roberta, De Michele, Sara, Dina, Carlotta Zanaboni, Porta, Mauro, Banfi, Giuseppe, and Briguglio M, Hrelia S, Malaguti M, Serpe L, Canaparo R, Dell'Osso B, Galentino R, De Michele S, Dina CZ, Porta M, Banfi G
- Subjects
0301 basic medicine ,Drug ,Pharmacologic processe ,media_common.quotation_subject ,precision medicine ,Pharmaceutical Science ,lcsh:RS1-441 ,food-drug interactions ,Review ,pharmacologic processes ,Bioinformatics ,Efficacy ,lcsh:Pharmacy and materia medica ,dietary supplements ,03 medical and health sciences ,Dietary supplement ,Nutraceutical ,herb-drug interaction ,Pharmacokinetics ,Herb-drug interaction ,Dietary supplements ,Food-drug interactions ,Herb-drug interactions ,Pharmacologic processes ,Precision medicine ,Medicine ,food-drug interaction ,Food-drug interaction ,media_common ,herb-drug interactions ,030109 nutrition & dietetics ,business.industry ,pharmacologic processe ,Bioavailability ,dietary supplement ,FooDB ,nutraceutical ,business ,DrugBank - Abstract
Preclinical and clinical studies suggest that many food molecules could interact with drug transporters and metabolizing enzymes through different mechanisms, which are predictive of what would be observed clinically. Given the recent incorporation of dietary modifications or supplements in traditional medicine, an increase in potential food-drug interactions has also appeared. The objective of this article is to review data regarding the influence of food on drug efficacy. Data from Google Scholar, PubMed, and Scopus databases was reviewed for publications on pharmaceutical, pharmacokinetic, and pharmacodynamic mechanisms. The following online resources were used to integrate functional and bioinformatic results: FooDB, Phenol-Explorer, Dr. Duke's Phytochemical and Ethnobotanical Databases, DrugBank, UniProt, and IUPHAR/BPS Guide to Pharmacology. A wide range of food compounds were shown to interact with proteins involved in drug pharmacokinetic/pharmacodynamic profiles, starting from drug oral bioavailability to enteric/hepatic transport and metabolism, blood transport, and systemic transport/metabolism. Knowledge of any food components that may interfere with drug efficacy is essential, and would provide a link for obtaining a holistic view for cancer, cardiovascular, musculoskeletal, or neurological therapies. However, preclinical interaction may be irrelevant to clinical interaction, and health professionals should be aware of the limitations if they intend to optimize the therapeutic effects of drugs.
- Published
- 2018
20. Dietary neurotransmitters: A narrative review on current knowledge
- Author
-
Carlotta Zanaboni Dina, Antonio Malgaroli, Giuseppe Banfi, Giancarlo Panzica, Roberta Galentino, Matteo Briguglio, Mauro Porta, Bernardo Dell'Osso, Briguglio, Matteo, Dell’Osso, Bernardo, Panzica, Giancarlo, Malgaroli, Antonio, Banfi, Giuseppe, Dina, Carlotta Zanaboni, Galentino, Roberta, and Porta, Mauro
- Subjects
0301 basic medicine ,Dopamine ,Review ,Gut flora ,Pharmacology ,acetylcholine ,diet, food, and nutrition ,dopamine ,functional foods ,gamma-aminobutyric acid ,glutamate ,gut microbiota ,histamine ,neurotransmitters ,serotonin ,chemistry.chemical_compound ,0302 clinical medicine ,Neurons ,Neurotransmitter Agents ,Nutrition and Dietetics ,biology ,Gamma-aminobutyric acid ,Glutamate receptor ,Glutamate ,lcsh:Nutrition. Foods and food supply ,Histamine ,Acetylcholine ,medicine.drug ,Biogenic Amines ,and nutrition ,Serotonin ,Glutamic Acid ,lcsh:TX341-641 ,Gut microbiota ,gamma-Aminobutyric acid ,03 medical and health sciences ,medicine ,Humans ,Neurotransmitter ,Nutrition ,food ,Functional food ,biology.organism_classification ,Bioavailability ,Diet ,030104 developmental biology ,chemistry ,nervous system ,Food ,diet ,030217 neurology & neurosurgery ,Food Analysis ,Food Science - Abstract
Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs. Relevant books and literature from PubMed and Scopus databases were searched for data on food sources of Ach, glutamate, GABA, dopamine, 5-HT, and histamine. Different animal foods, fruits, edible plants, roots, and botanicals were reported to contain NTs. These substances can either be naturally present, as part of essential metabolic processes and ecological interactions, or derive from controlled/uncontrolled food technology processes. Ripening time, methods of preservation and cooking, and microbial activity further contributes to NTs. Moreover, gut microbiota are considerable sources of NTs. However, the significance of dietary NTs intake needs to be further investigated as there are no significant data on their bioavailability, neuronal/non neuronal effects, or clinical implications. Evidence-based interventions studies should be encouraged.
- Published
- 2018
21. Critical aspects in the legal defence of patients with Tourette's Syndrome: An Italian case series
- Author
-
Guido Carlo Alleva, Mauro Porta, Domenico Servello, Bernardo Dell'Osso, Alberto R. Bona, and Carlotta Zanaboni Dina
- Subjects
Adult ,Male ,medicine.medical_specialty ,Obsessive-Compulsive Disorder ,Tourette's syndrome ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,medicine ,Humans ,In patient ,Justice (ethics) ,Social isolation ,Psychiatry ,Psychiatric Status Rating Scales ,Stalking ,Criminals ,Forensic Psychiatry ,Causality ,030227 psychiatry ,Psychiatry and Mental health ,Mental condition ,Italy ,Tics ,Proper treatment ,Female ,Crime ,medicine.symptom ,Psychology ,Law ,030217 neurology & neurosurgery ,Tourette Syndrome - Abstract
Tourette's syndrome (TS) is a developmental neurobehavioral disorder with childhood onset and relevant burden in terms of disability and reduced quality of life. In Italy the biological basis of this syndrome is still frequently ignored and TS is often recognised as a psychiatric manifestation, or even it is not recognised as pathology, which may result in inadequate treatment, social isolation and improper hospitalization. Indeed, the organic medical nature of TS needs to be taken into great consideration in evaluating causality of committing crimes in affected patients. In addition, delaying the diagnosis and consequently proper treatment has a devastating impact on social as well as legal aspects in patients with TS. The present report is aimed to present an Italian case series of 4 TS patients who faced legal problems related to their mental condition, in the intent to add further evidence, raise the level of awareness and encourage further investigation in the field, as in most of the cases, patients' illness was not taken into adequate account by the Justice. The relevant law is discussed in detail.
- Published
- 2017
22. Creativity Assessment in Subjects with Tourette Syndrome vs. Patients with Parkinson’s Disease: A Preliminary Study
- Author
-
Christian Saleh, Domenico Servello, Mauro Porta, and Carlotta Zanaboni Dina
- Subjects
tic ,medicine.medical_specialty ,Parkinson's disease ,media_common.quotation_subject ,Disease ,Affect (psychology) ,Tourette syndrome ,Article ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Dopamine ,medicine ,creativity ,Parkinson disease ,030212 general & internal medicine ,Creative thinking ,Psychiatry ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,media_common ,General Neuroscience ,medicine.disease ,Creativity ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology ,medicine.drug - Abstract
(1) Background: Literature suggests that high levels of dopamine are associated with creative thoughts. Tourette Syndrome (TS) patients have high dopamine levels, while Parkinson’s Disease (PD) subjects have low dopamine levels. Consequently, TS individuals are supposed to have a major and PD patients less creative output. Moreover, dopamine medications may alter the level of creativity, and therefore Quality of Life, in both pathologies. (2) Methods: The aim of the study was to verify the hypothesis of TS patients having higher creative scores than PD patients. The assessment consisted of the administration of the Creative Thinking ASK Test. There were 54 participants—36 males and 18 females—i.e., 27 TS patients and 27 PD subjects. Age of the sample was 35 to 57 years old, high school certificate was required. (3) Results: TS sample (103.11 ASK average score) was more creative than PD sample (94.11 ASK average score). (4) Conclusions: The results supported the aforementioned hypothesis: TS sample resulted in having higher creative scores than PD sample. Dopamine and other neurotransmitters of TS and PS appear to affect subject’s creativity. Further studies with creative assessments in TS and PD patients are needed to support the preliminary results of our study.
- Published
- 2017
23. Handwriting Tics in Tourette’s Syndrome: A Single Center Study
- Author
-
Edvin Zekaj, Alberto R. Bona, Domenico Servello, Carlotta Zanaboni Dina, and Mauro Porta
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Activities of daily living ,Tics ,lcsh:RC435-571 ,Case Report ,Affect (psychology) ,Single Center ,Obsessions ,03 medical and health sciences ,0302 clinical medicine ,Neurodevelopmental disorder ,Quality of life ,Handwriting ,lcsh:Psychiatry ,mental disorders ,medicine ,Early childhood ,Psychiatry ,Tourette ,medicine.disease ,nervous system diseases ,030227 psychiatry ,body regions ,Psychiatry and Mental health ,Psychology ,human activities ,030217 neurology & neurosurgery ,compulsions ,handwriting - Abstract
Tourette’s syndrome (TS) is a neurodevelopmental disorder typically defined by multiple motor tics and at least one sound tic (1), beginning in childhood or in adolescence. More recently, Tourette’s syndrome has been acknowledged as a broad spectrum syndrome (2), including different comorbidities and coexisting symptoms. When beginning in early childhood TS mainly presents with attention deficit and hyperactivity disorder (ADHD) and tics, when beginning in adolescence instead tics and obsessive-compulsive behavior or disorder (OCB/OCD) are predominant. OCB/OCD trait is present in 60-80% of patients (3), and they are considered as thought tics (4). In many cases motor and sound tics resolve spontaneously in adulthood, though OCB/OCD generally remain. Tics often interfere with subject’s daily activities (5) affecting Quality of Life and causing Social Impairment, particularly in schooling and working. Handwriting is one of the most impaired school activity for TS patients because of the tics presence that hamper learning processes. In our clinical experience handwriting tics (HT) could severely affect and condition TS subjects, but they are not often pointed out in the Literature. For this reason there are not precise data regarding the incidence of HT neither in Tourette’s syndrome patients nor in healthy population.
- Published
- 2016
24. Sixteen years of deep brain stimulation in Tourette's Syndrome: a critical review
- Author
-
Domenico, Servello, Edvin, Zekaj, Christian, Saleh, Carlotta, Zanaboni Dina, and Mauro, Porta
- Subjects
Treatment Outcome ,Thalamus ,Deep Brain Stimulation ,Humans ,Globus Pallidus ,Severity of Illness Index ,Tourette Syndrome - Abstract
The aim of this paper was to perform a critical and systematic review of the published papers on deep brain stimulation (DBS) for Tourette's Syndrome (TS).A PubMed search on DBS in TS was conducted selecting papers that reported on the clinical outcome of DBS.The majority of papers were case reports or small series. The thalamus and the globus pallidus internus appear to be the most promising targets. However, in light of the great methodological diversity a balanced comparison of clinical outcome and understanding of the role of DBS in TS remains difficult.Despite 16 years of experience with DBS in TS a consensus on many issues, foremost on target selection and the age of inclusion continue to be missing. Class I evidence and international collaborations, to increase the number of included patients, are urgently needed, in order to evaluate further the role of DBS in TS.
- Published
- 2016
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.