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Mast cell tumors represent the most common malignant skin tumor in the dog. This review outlines the incidence, etiology and clinical signs of mast cell tumors. Diagnostic tests, staging and treatments are also discussed. This study was performed by the Veterinary Oncology and Pathology of UNESP, Jaboticabal and the Service of Pathology Veterinary, of UNESP-Botucatu with the support of the Brazilian Association of Veterinary Oncology and the Brazilian Association of Veterinary Pathology.

Made available in DSpace on 2022-04-29T08:48:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-01-01 The aim of this study was to report the occurrence of two cases of thyroid neoplasm in dogs. The treatment of choice for these cases was surgical removal. In both cases the diagnostic was infiltrative follicular carcinoma of thyroid. The first animal did not present a good recovery after the surgery, and died four hours after the procedure. In the second case, the diagnosis was more precocious and antineoplastic chemotherapy was used after the surgery. At the time of submission of this manuscript, this animal had survived for fourty months. Currently, there is a need to define the protocols of chemotherapy to avoid relapse and metastases, in order to increase the life expectancy in dogs with thyroid neoplasm. Universidad de Franca, San Pablo Universidad Federal de lo Tocantins, Tocantins Universidad Estadual Paulista, Campus de Jaboticabal, San Pablo Universidad Federal de Uberlândia, Minas Gerais Universidad Federal de Goiás, Goiás Universidad Estadual Paulista, Campus de Jaboticabal, San Pablo

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:50:47Z No. of bitstreams: 1 S0100-736X2009000300012.pdf: 2618160 bytes, checksum: 5c9eb5ef085200f18e98712e03a31443 (MD5) Made available in DSpace on 2013-08-22T18:50:47Z (GMT). No. of bitstreams: 1 S0100-736X2009000300012.pdf: 2618160 bytes, checksum: 5c9eb5ef085200f18e98712e03a31443 (MD5) Previous issue date: 2009-03-01 Made available in DSpace on 2013-09-30T19:41:51Z (GMT). No. of bitstreams: 2 S0100-736X2009000300012.pdf: 2618160 bytes, checksum: 5c9eb5ef085200f18e98712e03a31443 (MD5) S0100-736X2009000300012.pdf.txt: 21597 bytes, checksum: 498610e123b9f7e17d57a2418e8789b1 (MD5) Previous issue date: 2009-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:05Z No. of bitstreams: 2 S0100-736X2009000300012.pdf: 2618160 bytes, checksum: 5c9eb5ef085200f18e98712e03a31443 (MD5) S0100-736X2009000300012.pdf.txt: 21597 bytes, checksum: 498610e123b9f7e17d57a2418e8789b1 (MD5) Made available in DSpace on 2014-05-20T13:14:05Z (GMT). No. of bitstreams: 2 S0100-736X2009000300012.pdf: 2618160 bytes, checksum: 5c9eb5ef085200f18e98712e03a31443 (MD5) S0100-736X2009000300012.pdf.txt: 21597 bytes, checksum: 498610e123b9f7e17d57a2418e8789b1 (MD5) Previous issue date: 2009-03-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Dezoito novilhos de diferentes raças, com idade de 18-24 meses foram submetidos a remoção do ligamento apical para ocasionar desvio de pênis. Decorridos 60 dias os animais foram colocados em presença de fêmeas em estro, sendo verificado desvio ventral e lateral direito do pênis, com incapacitade de cópula. Os animais foram submetidos ao transplante autólgo de um segmento da cartilagem do pavilhão auricular, sobre a túnica albugínea, substituindo o ligamento apical do pênis removido. Os bovinos quando em presença de fêmeas em estro não apresentaram desvio de pênis e alteração do comportamento sexual. Notou-se a presença de poucas células mononucleares, polimorfonucleares e células gigantes e formação de tecido conjuntivo fibroso, ocasionando aderências resistentes e capacidade de sustentar a extremidade livre do pênis. O método cirúrgico mostrou-se eficiente para corrigir desvios ventral e lateral de pênis de bovinos. Eighteen 18 to 24-month-old mixed breed bullocks were submitted to removal of the apical ligament of the penis to induce penile deviation. After 60 days from the surgery the steers were put together with cows in heat. A ventral and right lateral penis deviation leading to incapacity to copulate was observed. The bullocks were then submitted to an autolgous transplant of a cartilage segment from the ear pinna placed on top of the tunica albuginea, replacing the penile ligament apical tha had been removed. The implanted material was well tolerated; histologically with only infiltration few mononuclear cells, polymorpho nucleated cells and giant cells, and fibrosis, which caused strong adherence and provided ability to sustain the free penile extremity. The bullocks that were cows in heat did not show any degree of penile deviation nor any change in sexual behavior. The surgical method described here was shown to be satisfactory as to be indicated for correction of ventral and right lateral penile deviation in bullocks. Universidade Federal de Uberlândia Faculdade de Medicina Veterinária Universidade Federal de Goiás (UFG) Escola de Veterinária Departamento de Medicina Veterinária Universidade Estadual Paulista Faculdade de Medicina Veterinária Departamento de Clínica e Cirurgia Veterinária Universidade Paranaense Faculdade de Medicina Veterinária Departamento de Clínica e Cirurgia Veterinária Universidade Federal de Tocantins Escola de Medicina Veterinária e Zootécnia Universidade Estadual Paulista Faculdade de Medicina Veterinária Departamento de Clínica e Cirurgia Veterinária

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:00:05Z No. of bitstreams: 1 S0103-84782009000200045.pdf: 272340 bytes, checksum: dd053f15ff76a098d56490cf0dd20ec8 (MD5) Made available in DSpace on 2013-08-22T19:00:05Z (GMT). No. of bitstreams: 1 S0103-84782009000200045.pdf: 272340 bytes, checksum: dd053f15ff76a098d56490cf0dd20ec8 (MD5) Previous issue date: 2009-04-01 Made available in DSpace on 2013-09-30T19:57:57Z (GMT). No. of bitstreams: 2 S0103-84782009000200045.pdf: 272340 bytes, checksum: dd053f15ff76a098d56490cf0dd20ec8 (MD5) S0103-84782009000200045.pdf.txt: 21903 bytes, checksum: 1415f895f5eb6fefa51a0eec5b501108 (MD5) Previous issue date: 2009-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:04Z No. of bitstreams: 2 S0103-84782009000200045.pdf: 272340 bytes, checksum: dd053f15ff76a098d56490cf0dd20ec8 (MD5) S0103-84782009000200045.pdf.txt: 21903 bytes, checksum: 1415f895f5eb6fefa51a0eec5b501108 (MD5) Made available in DSpace on 2014-05-20T13:14:04Z (GMT). No. of bitstreams: 2 S0103-84782009000200045.pdf: 272340 bytes, checksum: dd053f15ff76a098d56490cf0dd20ec8 (MD5) S0103-84782009000200045.pdf.txt: 21903 bytes, checksum: 1415f895f5eb6fefa51a0eec5b501108 (MD5) Previous issue date: 2009-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Este estudo teve como objetivo descrever o primeiro relato de transplante de medula óssea (TMO) em cães no Brasil. Para tanto, um rottweiller com linfoma cutâneo foi submetido ao protocolo quimioterápico de Madison-Wisconsin pelo período de 12 semanas, seguido pelo transplante autólogo de medula óssea. Para tanto, 10mL kg-1 de medula óssea foram coletados de ambas as cristas ilíacas do paciente, simultaneamente; sendo o volume final criopreservado em freezer a -80°C. A etapa de condicionamento foi realizada com a administração da ciclofosfamida, por via intravenosa, na dose de 400mg m-2. A reinfusão da medula óssea foi realizada após o descongelamento da bolsa em banho-maria a 37°C. As contagens de células nucleadas de alíquotas obtidas da bolsa de medula óssea antes do congelamento e após o descongelamento demonstram pequena perda relativa de células nucleadas (35,10 e 31,80 x10³µL-1, respectivamente). A neutropenia decorrente da ciclofosfamida foi revertida com a administração de um fator estimulador de colônia de granulócitos (G-CSF), que foi capaz de acelerar a reconstituição hematopoética. O paciente encontra-se no dia + 360 pós-transplante em remissão completa da doença. Este trabalho indicou que o TMO autólogo em um cão com linfoma, submetido à quimioterapia mielossupressora, foi potencialmente seguro e efetivo. The objective of this study is to provide the first report of bone marrow transplantation (BMT) in dogs in Brazil. A Rottweiler with cutaneous lymphoma was submitted to a twelve-week Madison-Wisconsin chemotherapy protocol followed by autologous bone marrow transplantation. For this, 10mL kg-1 of bone marrow was collected simultaneously from both iliac crests and cryopreserved in a freezer at -80°C. The conditioning step was performed by administering cyclophosphamide by intravenous route at 400mg m-2. Bone marrow was reinfused after defrosting in a water bath at 37°C. Bone marrow nucleated cell counts before and after freezing, showed a small relative loss of nucleated cells (35.10 and 31.80x10³µL-1 , respectively). Cyclophosphamide induced neutropenia which was reverted by a granulocyte colony-stimulating factor (G-CSF) capable of stimulating hematopoetic reconstitution. on the day 360 after transplant the patient was found to be in complete remission. This study indicates that autologous BMT in a dog with lymphoma submitted to myelosuppressive chemotherapy was potentially safe and effective. Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento Clínica e Cirugia Veterinária Centro Universitário Barão de Mauá Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento Clínica e Cirugia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias FAPESP: 05/01617-8 FAPESP: 06/03300-1

Made available in DSpace on 2015-08-26T19:19:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-01. Added 1 bitstream(s) on 2015-08-31T13:04:50Z : No. of bitstreams: 1 S0102-09352015000100119.pdf: 772031 bytes, checksum: 8883806b630ddae5831d1cbba4da93d6 (MD5) Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) Avaliaram-se a macroscopia e a microestrutura de esferas compostas por cimento ósseo de alfa-fosfato tricálcico de dupla pega munido de canais de interconexão (alfa-TCP-i) e a integração do implante ao tecido orbital de coelhos através de análise macroscópica e histopatológica. A superfície interna e externa do alfa-TCP-i foi avaliada macroscopicamente e por microscopia eletrônica. Após enucleação do bulbo ocular esquerdo, 12 coelhos da raça Nova Zelândia receberam implantes do alfa-TCP-i com 12mm de diâmetro. A avaliação clínica foi realizada diariamente nos primeiros 15 dias e depois a cada quinze dias até o fim do período de estudo. Para análise morfológica, seguiu-se a exenteração de três animais por período experimental (15, 45, 90 e 180 dias). As superfícies externa e interna do implante mostraram-se compactas, sólidas e lisas, com seis canais que se interconectavam centralmente. A microarquitetura caracterizou-se pela formação de colunas de cristais hexagonais. Sinais de infecção, exposição, deiscência de sutura ou extrusão não foram notados em nenhum dos animais durante o período de estudo. A análise morfológica revelou a presença de fina cápsula ao redor do implante de onde surgiram projeções fibrovasculares que o penetraram através dos canais de interconexão. Nos primeiros dias após a inserção das esferas, notou-se intensa reação inflamatória que se mostrou ausente aos 180 dias. O implante do cimento de alfa-fosfato tricálcico foi bem tolerado em coelhos, mostrou-se relativamente inerte e permitiu a infiltração de tecido fibrovascular através dos canais de interconexão. The purpose of this study was to evaluate the macroscopy and microstructure of a double setting alpha-tricalcium phosphate bone cement sphere provided with interconnection channels (alpha-TCP-i), as well as the integration of the implant with the rabbits' orbital tissue, through macroscopic analysis and histopathology. The external and internal surfaces of the alpha-TCP-i were evaluated macroscopically and by electron microscopy. Twelve New Zealand rabbits received 12mm implants of alpha-TCP-i following enucleation of the left eye. The clinical assessment was undertaken daily during the first 15 days, followed by fortnightly assessment until the end of the study period. For the morphological analysis, exenteration was performed in 3 animals per experimental period (15, 45, 90 and 180 days). The external and internal surfaces of the implant appeared solid, smooth and compact, with six channels which interconnected centrally. The micro-architecture was characterized by the formation of columns of hexagonal crystals. No signs of infection, exposure, dehiscence of sutures or extrusion of the implant were noted in any of the animals during the entire period of the study. The morphological evaluation demonstrated the presence of a thin capsule around the implant, from whence appeared fibro-vascular projections, which penetrated it through the interconnecting channels. In the first days after the insertion of the implant, an intense inflammatory reaction was noted. At 180 days, however, there were no signs of inflammation. The alpha-tricalcium phosphate cement implant was well tolerated in this rabbit model and appeared to be relatively inert with some fibrovascular ingrowth through the large channels. Universidade Estadual Paulista Universidade Federal da Bahia União Metropolitana de Educação e Cultura Universidade Federal do Rio Grande do Sul Universidade Estadual Paulista FAPESB: 5881-2009

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:24Z No. of bitstreams: 1 S0103-84782003000400019.pdf: 189921 bytes, checksum: add154205a71b57f99a4f58839ba920f (MD5) Made available in DSpace on 2013-08-22T18:59:24Z (GMT). No. of bitstreams: 1 S0103-84782003000400019.pdf: 189921 bytes, checksum: add154205a71b57f99a4f58839ba920f (MD5) Previous issue date: 2003-08-01 Made available in DSpace on 2013-09-30T19:56:15Z (GMT). No. of bitstreams: 2 S0103-84782003000400019.pdf: 189921 bytes, checksum: add154205a71b57f99a4f58839ba920f (MD5) S0103-84782003000400019.pdf.txt: 20554 bytes, checksum: 52e58683a0e181924cd8c8708b933154 (MD5) Previous issue date: 2003-08-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:15:52Z No. of bitstreams: 2 S0103-84782003000400019.pdf: 189921 bytes, checksum: add154205a71b57f99a4f58839ba920f (MD5) S0103-84782003000400019.pdf.txt: 20554 bytes, checksum: 52e58683a0e181924cd8c8708b933154 (MD5) Made available in DSpace on 2014-05-20T13:15:52Z (GMT). No. of bitstreams: 2 S0103-84782003000400019.pdf: 189921 bytes, checksum: add154205a71b57f99a4f58839ba920f (MD5) S0103-84782003000400019.pdf.txt: 20554 bytes, checksum: 52e58683a0e181924cd8c8708b933154 (MD5) Previous issue date: 2003-08-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Este estudo visou avaliar a eficácia do método de biópsia hepática laparoscópica por cauterização e estudar os seus efeitos no fígado de cães sadios. Além disso, procurou-se verificar as principais alterações hematológicas e bioquímicas-séricas relacionadas às funções hepáticas e averiguar a viabilidade dos fragmentos colhidos por exame de histopatologia. Para tanto, 21 cães clinicamente sadios pesando entre 10 e 15kg, foram separados em três grupos de sete animais cada grupo. As amostras foram retiradas da borda no lobo lateral esquerdo, utilizando-se pinça de biópsia conectada a eletrocautério na freqüência de 45W. Foram realizadas 42 biópsias hepáticas por laparoscopia nos 21 animais supra- referidos. No grupo I, colheu-se um fragmento hepático por animal. No grupo II, colheram-se dois fragmentos e no grupo III, colheram-se três fragmentos por animal. Os cães foram avaliados nos períodos pré, pós-operatório (tempos 4h e 6h) e aos 30 dias de evolução. Os resutados obtidos revelaram que não houve alterações hematológicas, bioquímicas e histopatológicas relacionadas à técnica. Não foram observadas alterações significativas nos parâmetros estudados, sugerindo que não ocorreram alterações hepáticas que comprometessem a função do órgão. Hepatic biopsy was realized through laparoscopy with simultaneous cauterization in the present study, whose principal aim was to evaluate the efficacy of the applied method and to study its effects in the liver of healthy dogs. Furthermore, we tried to verify the main hematological and chemistry profile alterations related to the hepatic function, and to investigate the viability of the fragments collected by histopathology. To attain this objective, 21 clinically healthy dogs, weighing between 10 and 15kg were submitted to hepatic biopsy with forceps connected to the cautery. Cautery was performed by applying radiofrequency energy at 45 watts. Forty-two hepatic biopsies through laparoscopy were conducted in the animals. At group I one hepatic fragment per animal was collected, at group II two hepatic fragments per animal were collected, and at group III three fragments were collected. Hematocrit and alanine-aminotransferase measurements were employed to evaluate the animals at the pre-operative period, at four and six hour post-operative, and at day 30 post-operative. The results revealed that the procedure was safe and effective for hepatic biopsy in dogs. There were no clinical alterations related to the technique. The fragments collected were viable for histopathology. Hepatic biopsy through laparoscopy with simultaneous cauterization is an effective and usefull method in dogs. UNESP Faculdade de Ciências Agrárias e Veterinárias UNESP Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária UNESP Faculdade de Ciências Agrárias e Veterinárias Departamento de Patologia Veterinária Universidade Federal da Paraíba UNESP Faculdade de Ciências Agrárias e Veterinárias UNESP Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária UNESP Faculdade de Ciências Agrárias e Veterinárias Departamento de Patologia Veterinária

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:58:04Z No. of bitstreams: 1 S0102-86502003000400010.pdf: 2414096 bytes, checksum: d7220cc3a262b08179698fb898b4e679 (MD5) Made available in DSpace on 2013-08-22T18:58:04Z (GMT). No. of bitstreams: 1 S0102-86502003000400010.pdf: 2414096 bytes, checksum: d7220cc3a262b08179698fb898b4e679 (MD5) Previous issue date: 2003-08-01 Made available in DSpace on 2013-09-30T19:53:27Z (GMT). No. of bitstreams: 2 S0102-86502003000400010.pdf: 2414096 bytes, checksum: d7220cc3a262b08179698fb898b4e679 (MD5) S0102-86502003000400010.pdf.txt: 21953 bytes, checksum: 779a79ec168ecaffe8c8d7afe04fa537 (MD5) Previous issue date: 2003-08-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:06Z No. of bitstreams: 2 S0102-86502003000400010.pdf: 2414096 bytes, checksum: d7220cc3a262b08179698fb898b4e679 (MD5) S0102-86502003000400010.pdf.txt: 21953 bytes, checksum: 779a79ec168ecaffe8c8d7afe04fa537 (MD5) Made available in DSpace on 2014-05-20T13:14:06Z (GMT). No. of bitstreams: 2 S0102-86502003000400010.pdf: 2414096 bytes, checksum: d7220cc3a262b08179698fb898b4e679 (MD5) S0102-86502003000400010.pdf.txt: 21953 bytes, checksum: 779a79ec168ecaffe8c8d7afe04fa537 (MD5) Previous issue date: 2003-08-01 OBJETIVO: Avaliar a função renal de cães sadios, sob dois protocolos para administração de cisplatina. MÉTODOS: Todos os animais foram submetidos a três sessões de quimioterapia com cisplatina (60mg/m², iv) a intervalos de 21 dias. Foi realizada fluidoterapia com solução de cloreto de sódio a 0,9%, (25mL/kg/hora,iv), durante duas horas e, após administração de cisplatina, por mais uma hora. Os animais do grupo 2 receberam furosemida (2mg/kg, iv) 20 minutos antes da administração da cisplatina. A avaliação da função renal foi feita por exame clinico, urinálise, concentrações séricas de uréia e creatinina, clearance de creatinina, excreção fracionada de sódio e de potássio e razão proteína: creatinina urinária. As avaliações foram feitas imediatamente antes e 1, 2, 5, e 21 dias após cada uma das três sessões de quimioterapia. RESULTADOS: Mantiveram-se dentro da normalidade, não sendo detectados sinais de lesões ou insuficiência renal. Os animais que não receberam furosemida sofreram aumento gradativo nas concentrações séricas de creatinina e diminuição no clearance da mesma. CONCLUSÃO: O regime de fluidoterapia empregado mostra ser efetivo em minimizar a ação nefrotóxica da cisplatina e benefício adicional importante é obtido pela administração de furosemida. PURPOSE: Evaluated the renal function of healthy dogs under two protocols for cisplatin administration. METHODS: All animals were under three chemotherapy sessions with cisplatin (60mg/m², i.v) at 21 days intervals. It was administerd, as fluid therapy, 0,9% sodium chloride solution (25mL/kg/hour, i.v), for two hours and, after cisplatin administration, for more one hour. The animals of the group 2 received furosemide (2mg/kg, i.v.) 20 minutes before the cisplatin administration. The renal function evaluation was made by physical examination, urinalisis, urea and creatinine serum levels, creatinine clearance, sodium and potassium fractional excretions, and urinary protein:creatinine ratio. The evaluations were done imidiatilly before, 1, 2, 5 and 21days after each one of the three chemotherapy sessions. RESULTS: All results were in the interval of normal variation, and no signs of renal damage or failure were detected. The animals that did not recive furosemide showed gradual increment of creatinine serum levels and decreases of the creatinine clearance. CONCLUSIONS: The protocol for fluid therapy seem to be effective in minimize the nephrotoxic action of cisplatin and an addition importante benefit is obtained with furosemide administration. Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias

Osteossarcoma (OSA) ou sarcoma osteogênico é a neoplasia óssea primária mais freqüente em cães. Vários procedimentos terapêuticos tem sido adotados sempre com o objetivo de melhorar a qualidade de vida do paciente. Este trabalho de revisão teve como objetivo apresentar aos profissionais da medicina veterinária de pequenos animais informações desta neoplasia no que diz respeito ao seu comportamento biológico, diagnóstico, opções de tratamento e prognóstico.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:55:32Z No. of bitstreams: 0 Made available in DSpace on 2013-08-22T18:55:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-06-01 Made available in DSpace on 2013-09-30T19:48:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:15:52Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:15:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Este trabalho teve por objetivo estudar as diferenças ultraestruturais de mastócitos neoplásicos de diferentes tipos histológicos de mastocitoma em cães, usando microscopia eletrônica de transmissão Os resultados mostraram que o núcleo e os grânulos citoplasmáticos são as estruturas mais indicadas para se avaliar o grau de anaplasia celular e o estádio de indiferenciação do tumor. The objective of this work was study the ultrastructural differences among the different histologic types of mast cell tumors in dogs collected in vivo. The ultrastructural analyses showed that the nuclei and cytoplasmic granules characteristics are the best structures to be appointed on evaluating the undifferentiation stage of this tumor. UNESP Faculdade de Ciências Agrárias e Veterinárias UNESP Faculdade de Ciências Agrárias e Veterinárias

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:58:02Z No. of bitstreams: 0 Made available in DSpace on 2013-08-22T18:58:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2001-09-01 Made available in DSpace on 2013-09-30T19:53:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2001-09-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:13:52Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:13:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2001-09-01 Um sistema de liberação constituído por hidroxiapatita e cisplatina foi testado em ratos para avaliação da liberação local e sistêmica do antineoplásico cisplatina. Os animais que receberam os implantes com a droga desenvolveram efeitos colaterais ao tratamento, sendo os mais comuns: anorexia, diarréia, epistaxe e necrose cutânea no sítio de implantação; cerca de 45% deste animais morreram, indicando intoxicação. Amostras de sangue e dos tecidos hepático, renal e muscular de todos os animais pertencentes ao experimento foram submetidas à detecção das concentrações de cisplatina, revelando a cinética de liberação da droga pelo sistema proposto. The drug release system constituted by hydroxyapatite and cisplatin was tested in rats for local and systemic drug release. The side effects to treatment were: anorexia, diarrhea, epistaxe e cutaneous necrose in the implantation bed; 45% animals of test group died by treatment intoxication. Serum, renal, hepatic and muscular tissues samples were collected for cisplatin analysis of all animals that received implants, showing system's kinetics. Universidade Metodista de São Paulo Faculdade de Medicina Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Tecnologia Universidade Estadual Paulista Faculdade de Ciências Agrárias Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Tecnologia

Made available in DSpace on 2016-04-01T18:43:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2013. Added 1 bitstream(s) on 2016-04-01T18:49:20Z : No. of bitstreams: 1 ISSN0301-732X-2013-45-03-311-316.pdf: 731886 bytes, checksum: 4b14adb2974e76f16efbc89865c3c597 (MD5) The aim of this study was to detect the expression of ciclooxigenase-2 (COX-2) in metastatic primary carcinoma and non metastatic carcinoma, taking into consideration the relation between COX-2 and the progression of cancer. Evaluation of the COX-2 expression was achieved by immunohistochemistry analysis, using the primary polyclonal antibody anti-PGHS-2, clone PG 27, (Oxford Biomedical Research). The number of marked cells by the COX-2 antibody was higher (P < 0.001) in the metastatic primary carcinoma (81.25%) than non-metastatic (60.3%). There was a positive correlation between the number of labeled cells. Teniendo en cuenta la relación de la ciclooxigenasa-2 (COX-2) con la progresión del cáncer, el objetivo de este trabajo fue investigar la expresión de la COX-2 en los carcinomas mamarios primarios, metastásicos y no metastásicos en perras. La evaluación de la expresión de COX-2 fue realizada por inmunohistoquímica, utilizando anticuerpo policlonal primario anti-PGHS-2, clon PG 27, (Oxford Biomedical Research). El número de células marcadas por el anticuerpo COX-2 fue significativamente mayor (P < 0.001) en los carcinomas primarios metastásicos (81,25%) comparados con los no metastásicos (60,3%). Existe correlación positiva entre el número de células marcadas COX-2 y el grado de invasión tumoral (carcinoma mamario primario metastásico y no metastásico). Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica y Cirugía Veterinaria, Faculdade de Ciências Agrárias e Veterinárias (FCAV), Jaboticabal, SP, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Veterinaria, Faculdade de Medicina Veterinária e Zootecnia de Botucatu, Botucatu, Distrito de Rubião Jr. s/n - Departamento de Clínica Veterinária - Patologia Veterinária, Rubião Jr, CEP 18610-000, SP, Brasil Departamento de Medicina Veterinaria, Universidad Federal de Paraná, Campus Curitiba, Paraná, Brasil Universidad Estadual del Norte de Paraná, Bandeirantes, Paraná, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica y Cirugía Veterinaria, Faculdade de Ciências Agrárias e Veterinárias (FCAV), Jaboticabal, SP, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Veterinaria, Faculdade de Medicina Veterinária e Zootecnia de Botucatu, Botucatu, Distrito de Rubião Jr. s/n - Departamento de Clínica Veterinária - Patologia Veterinária, Rubião Jr, CEP 18610-000, SP, Brasil

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:00:20Z No. of bitstreams: 1 S0103-84782011000700022.pdf: 65832 bytes, checksum: 0d0d6c970ccd6c197f596a54135080e6 (MD5) Made available in DSpace on 2013-08-22T19:00:20Z (GMT). No. of bitstreams: 1 S0103-84782011000700022.pdf: 65832 bytes, checksum: 0d0d6c970ccd6c197f596a54135080e6 (MD5) Previous issue date: 2011-07-01 Made available in DSpace on 2013-09-30T19:58:43Z (GMT). No. of bitstreams: 2 S0103-84782011000700022.pdf: 65832 bytes, checksum: 0d0d6c970ccd6c197f596a54135080e6 (MD5) S0103-84782011000700022.pdf.txt: 30033 bytes, checksum: 803e825d6b3b910c02b9df6599146d70 (MD5) Previous issue date: 2011-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:04Z No. of bitstreams: 2 S0103-84782011000700022.pdf: 65832 bytes, checksum: 0d0d6c970ccd6c197f596a54135080e6 (MD5) S0103-84782011000700022.pdf.txt: 30033 bytes, checksum: 803e825d6b3b910c02b9df6599146d70 (MD5) Made available in DSpace on 2014-05-20T13:14:04Z (GMT). No. of bitstreams: 2 S0103-84782011000700022.pdf: 65832 bytes, checksum: 0d0d6c970ccd6c197f596a54135080e6 (MD5) S0103-84782011000700022.pdf.txt: 30033 bytes, checksum: 803e825d6b3b910c02b9df6599146d70 (MD5) Previous issue date: 2011-07-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) O linfoma é uma neoplasia de elevada incidência na população canina mundial, e que apresenta sinais clínicos diversos, dependentes da classificação anatômica e da extensão da doença. Este estudo objetivou avaliar as características clínicas e hematológicas de cães com linfoma no momento do diagnóstico, além da evolução clínica dos mesmos ao longo do tratamento com o protocolo de Madison-Wisconsin. Dos 18 cães inseridos no estudo, 50% apresentaram a forma multicêntrica da doença e 33% a forma cutânea. A manifestação clínica mais comum foi a linfadenomegalia superficial, acompanhada dos sinais sistêmicos de hiporexia, apatia e perda de peso. As principais alterações hematólogicas foram anemia normocítica normocrômica, trombocitopenia e leucocitose, associadas às síndromes paraneoplásicas. Vinte e sete por cento dos animais atingiram remissão completa da doença e apenas 22% atingiram sobrevida de um ano. Houve correlação positiva entre o valor do hematócrito e o tempo de sobrevida para os cães que morreram, demonstrando a influência da anemia no prognóstico dos animais. Sugere-se que o estágio avançado da doença no momento do diagnóstico tenha influenciado as baixas taxas de remissão e sobrevida obtidas neste estudo. Lymphoma is a neoplasm of high incidence in dogs, and has several clinical signs, depending on the tumor anatomical area and the extent of the disease. This study aimed to evaluate the clinical and hematological findings in dogs with lymphoma at diagnosis, and the clinical evolution during Madison-Wisconsin chemotherapy protocol. of the 18 dogs that underwent the study, 50% of the dogs had the multicentric form and 33% the cutaneous forms of the disease. The most common clinical sign was superficial lymphadenomegaly, combined to systemic signs of hyporexia, apathy and weight loss. The main hematological changes were anemia, thrombocytopenia and leukocytosis, associated with paraneoplastic syndromes. Complete remission was achieved in 27% of the animals and the one-year survival rate was 22%. There was a positive correlation between the hematocrit and survival time in dogs that died, which indicates the importance of anemia in the prognosis. It is suggested that the advanced stage of the disease may have contributed to the low remission and survival rates observed in this study. Centro Universitário Barão de Mauá Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária FAPESP: 05/01718-6 FAPESP: 06/03300-1

Sabendo-se da influência das mutações no gene TP53 no desenvolvimento das neoplasias e da discrepância entre os resultados obtidos pelas técnicas de sequenciamento e imunoistoquímica, esta pesquisa teve como objetivo relacionar a sequência do TP53 com a imunorreatividade da p53. Foram obtidas amostras de linfoma de 12 cães. O diagnóstico histopatológico foi determinado pela classificação de Kiel. O imunofenótipo e a imunomarcação da p53 foram determinados por imunoistoquímica. Para reação com a p53, utilizou-se anticorpo policlonal anti-p53 (CM1) na diluição de 1:500. A região do gene TP53 compreendida entre os exons quatro e nove foi amplificada por PCR e submetida ao sequenciamento. Apesar dos resultados obtidos pela imunoistoquímica, nenhuma mutação foi encontrada nas sequências analisadas. Conclui-se que a imunorreatividade da p53 pela imunoistoquímica não pode ser atribuída à presença de mutações no domínio central do gene TP53. TP53 mutations are usually involved in cancer, but sequencing and immunohistochemistry results are often controversial. Thus, the aim of this study was to associate TP53 sequence with p53 immunostaining in dogs with lymphoma. Tumor samples were collected from 12 dogs with lymphoma and were included in this study. Histopathological diagnosis was performed according to Kiel classification. Immunohistochemistry was performed to identify immunophenotype as well as p53 expression. Polyclonal antibody anti-p53 (CM1) was used at a 1:500 dilution. The region that encompasses exons 4-9 was amplified by f PCR reactions and sequencing was then performed. Nevertheless, gene mutations were not observed in any sequence. In conclusion, immunoreactivity of p53 by means of immunohistochemistry should not be indicator of presence of mutations in the core domain of TP53 gene.

Made available in DSpace on 2022-04-29T08:44:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Objective: To evaluate the average values of the hemogram test in healthy dogs during chemotherapy with cisplatin. Materials and methods: The hemogram parameters of eight healthy canines, which underwent therapy with cisplatin, were evaluated. These canines were divided into two groups. The dogs in the first group were given cisplatin (70mg/m2, i.v.) and to prevent kidney poisoning they were given physiological serum at 0.9% (25mL/kg/h, i.v.). The dogs in group two were not given cisplatin. Results: The hemogram of the dogs in the first group did not show any significant difference (p>0.05) as compared to the dogs in group 2. Conclusion:. The data obtained indicate the protocol used with cisplatine does not significantly alter the average values of the hemogram test and the number of chemotherapy sessions increases the risk of diminishing the values of the hemogram test. Universidad de Nariño Facultad de Ciencias Pecuarias Departamento de Sanidad Animal, Torobajo, Pasto, Nariño Universidad Estatal Paulista Facultad de Medicina Veterinaria y Zootecnia Servicio de Oncología Veterinaria, Jaboticabal, Estado de São Paulo

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:22Z No. of bitstreams: 1 S0102-09352010000200012.pdf: 155781 bytes, checksum: ae9ddbf4627c275ad1d648ff96e27658 (MD5) Made available in DSpace on 2013-08-22T18:56:22Z (GMT). No. of bitstreams: 1 S0102-09352010000200012.pdf: 155781 bytes, checksum: ae9ddbf4627c275ad1d648ff96e27658 (MD5) Previous issue date: 2010-04-01 Made available in DSpace on 2013-09-30T19:50:13Z (GMT). No. of bitstreams: 2 S0102-09352010000200012.pdf: 155781 bytes, checksum: ae9ddbf4627c275ad1d648ff96e27658 (MD5) S0102-09352010000200012.pdf.txt: 33664 bytes, checksum: 1adadc84b1f01dd557297fc8c51d1afa (MD5) Previous issue date: 2010-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:13:08Z No. of bitstreams: 2 S0102-09352010000200012.pdf: 155781 bytes, checksum: ae9ddbf4627c275ad1d648ff96e27658 (MD5) S0102-09352010000200012.pdf.txt: 33664 bytes, checksum: 1adadc84b1f01dd557297fc8c51d1afa (MD5) Made available in DSpace on 2014-05-20T15:13:08Z (GMT). No. of bitstreams: 2 S0102-09352010000200012.pdf: 155781 bytes, checksum: ae9ddbf4627c275ad1d648ff96e27658 (MD5) S0102-09352010000200012.pdf.txt: 33664 bytes, checksum: 1adadc84b1f01dd557297fc8c51d1afa (MD5) Previous issue date: 2010-04-01 Avaliou-se o efeito da eletroacupuntura (EA) sobre os aspectos macroscópicos e microscópicos em 36 coelhos que tiveram o tendão calcanear comum seccionado e que, após 30 dias, receberam enxerto de peritônio bovino conservado em solução saturada de sal. Após a cirurgia, os animais foram distribuídos em três grupos de igual número: os do grupo E10 foram estimulados pela EA do segundo ao 11º dia de pós-operatório, os do grupo E20 do 11º ao 31º dia de pós-operatório e os do grupo C não foram estimulados. Posteriormente, os animais foram redistribuídos em três subgrupos de igual número, os quais foram observados no pós-operatório por 11, 31 e 91 dias. Nos coelhos do E10 e E20, ocorreu diminuição de aderência da área enxertada aos tecidos circunvizinhos. Aos 31 dias de pós-operatório, observou-se nos do E10 tecido conjuntivo. Verificou-se intensa neovascularização no local enxertado em todos os animais que receberam estímulo pela EA. Nos coelhos do E10, aos 91 dias, verificou-se intensa quantidade de tecido conjuntivo, com fibras colágenas organizadas e paralelas ao eixo do tendão. O estímulo pela EA na fase precoce do pós-operatório estimulou a maturação cicatricial com mínima reação inflamatória. The effects of eletro-acupuncture (EA) were evaluated on clinical and histological aspects in 36 rabbits that had the acchiles tendon sectioned and grafted after 30 days using bovine peritoneum graft preserved in saturated salt solution. The animals were randomly distributed into three groups. They were stimulated by EA from the 2nd to the 11th post-operative day (S10 group), from the 11th to the 31st post-operative day (S20 group), and were not stimulated (C group). Then, the rabbits were distributed into three sub-groups and were observed for 11, 31, and 91 days. The rabbits from S10 and S20 groups presented decreased adhesions between graft and adjacent tissues. The rabbits from S10 group showed connective tissue at 31 days of the post-operative period. Intense graft neovascularization was observed in all animals stimulated by EA. Large amounts of connective tissue with organized and parallel to the tendon axis collagen fibers were detected on the day 91st in the S10 group animals. The early EA stimulation during the post-operative period stimulated the tendon healing with minimal inflammatory reaction. Universidade Federal do Espirito Santo UNESP, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil Universidade Federal de Uberlândia UNESP, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:08Z No. of bitstreams: 2 S0102-09352009000500005.pdf: 327878 bytes, checksum: 26eae606fe2ef4150bf2cfb5b80f68e7 (MD5) S0102-09352009000500005.pdf.txt: 14480 bytes, checksum: 25c09eee3fb694067a868fedda4c5288 (MD5) Made available in DSpace on 2014-05-20T13:14:08Z (GMT). No. of bitstreams: 2 S0102-09352009000500005.pdf: 327878 bytes, checksum: 26eae606fe2ef4150bf2cfb5b80f68e7 (MD5) S0102-09352009000500005.pdf.txt: 14480 bytes, checksum: 25c09eee3fb694067a868fedda4c5288 (MD5) Previous issue date: 2009-10-01 Fundação para o Desenvolvimento da UNESP (FUNDUNESP) Foram avaliadas amostras de soro sanguíneo de 10 cães sadios e de 12 com linfoma, utilizando-se a eletroforese em gel de poliacrilamida contendo dodecil sulfato de sódio. Houve diferença entre as médias dos teores de proteína total de cães sadios, 7,68g/dL±0,46 e de cães com linfoma, 7,93g/dL±2,49. As concentrações de IgA e IgG não foram diferentes entre os grupos. Os teores das proteínas de pesos moleculares 142000, 110000, 52000, 49000, 24000 e 18000 dáltons foram mais elevados em cães com linfoma. Os cães com linfoma apresentaram concentrações mais elevadas de ceruloplasmina, 43,95mg/dL±18,19, e haptoglobina, 554mg/dL±449,51, e menores de albumina, 2908mg/dL±476,67, em comparação aos cães sadios (ceruloplasmina: 3,42mg/dL±7,44; haptoglobina: 94,54mg/dL±59,50 e albumina: 4207mg/dL±206,18). Conclui-se que concentrações séricas mais elevadas de ceruloplasmina e haptoglobina e menores de albumina podem estar associadas ao linfoma em cães. Blood serum samples of ten healthy dogs and 12 dogs with lymphoma were evaluated by means of sodium dodecil sulphate-polyacrylamide gel electrophoresis. There was difference in total protein concentrations among healthy dogs, 7.68g/dL±0.46 and dogs with lymphoma, 7.93g/dL±2.49 values of immunoglobulins A and G presented no difference between groups. Serum proteins with molecular weights 142,000; 110,000; 52,000; 49,000; 24,000; and 18,000 Daltons presented increased concentrations in dogs with lymphoma. Dogs with lymphoma presented increased ceruloplasmin (43.95mg/dL±18.19) and haptoglobin (554mg/dL±449.51) values and lesser albumin concentration (2,908mg/dL±476.67) when compared to healthy dogs (ceruloplasmin: 3.42mg/dL±7.44; haptoglobin: 94.54mg/dL±59.50, and albumin: 4,207mg/dL±206.18). In conclusion, increased ceruloplasmin and haptoglobin and lesser albumin serum concentrations are possibly related to lymphoma in dogs. UNESP, Aluno Posgrad FCAV, Jaboticabal, SP, Brazil UNESP, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil Universidade de Marília Universidade de Franca UNESP, Aluno Posgrad FCAV, Jaboticabal, SP, Brazil UNESP, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:24:33Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:46:39Z : No. of bitstreams: 1 2-s2.0-78149369097.pdf: 1198792 bytes, checksum: 8aa1d33a0831b082162b5eff41688891 (MD5) Made available in DSpace on 2014-05-27T11:24:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-12-01 18 rabbits, New Zealand, males, adults were used for clinical and histological evaluation of repair dorsal buccal branch of facial nerve after 15, 30 and 60 days postoperatively (PO). The animals were divided into two groups for transection and 10-0 nylon monofilament epineural suture of buccal branch. In animals in Group I, the nerve was coated with protection of jejunum allograft preserved in glycerin 98% and in group II was applied epineural suture. Both groups occurred the return of movement of the upper lip from the eighth week. There was infiltrated cellular and giant cells with fibrosis unsystematic and collagen fibers of the allograft jejunum joing to the connective tissue. At 15 and 30 days of PO, the distal nerve stumps of both groups were found with degeneration wallerian and in 60 days, regenerated fibers. The repair of the dorsal buccal branch of facial nerve with the allograft wasn't significantly different between the control rabbits as to the assessment of histological and functional recovery. Faculdade de Medicina Veterinária Universidade Federal de Uberlândia, Uberlândia-MG Escola de Veterinária Universidade Federal de Goiás, Goiás-GO Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista, Jaboticabal - SP Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista, Jaboticabal - SP

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:23:48Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:46:22Z : No. of bitstreams: 1 2-s2.0-78149378432.pdf: 922601 bytes, checksum: c93131dbd29655d76fade1e75a9e94ba (MD5) Made available in DSpace on 2014-05-27T11:23:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-12-01 The behaviour of the non conserved and 98% glycerin conserved specimens for periods of 30, 60 and 90 days of bovine diaphragma's tendinous center, fibrous pericardium and parietal peritoneum submitted to mechanical tests of traction, was observed in ten bovines between 30 months and 36 months of age, crossbreeds, males and females, collecting fragments of these aforesaid membranes in each animal. The diaphragma's tendinous center and parietal peritoneum did not suffered significant modification (p>0.05) in the values of tension when compared to the resistance tests of traction of non conserved and 98% glycerin conserved membranes. However, all the evaluated tissues showed significant increase (p£0.05) of the elongation values when conserved in 98% glycerin for until 90 days. It was also observed that fibrous pericardium is the one which supports greaters tensions. So, it to was concluded, that glycerin is efficient to the conservation of biological membranes besides modifying its mechanical properties. Curso de Medicina Veterinária Centro Universitário Barão de Mauá, Ribeirão Preto-SP Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal-SP Departamento de Biomecânica Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto-SP Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal-SP

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:56Z No. of bitstreams: 1 S0103-84782008000300037.pdf: 27770 bytes, checksum: c688ad5b681f9afc93768cbbe28f196a (MD5) Made available in DSpace on 2013-08-22T18:59:56Z (GMT). No. of bitstreams: 1 S0103-84782008000300037.pdf: 27770 bytes, checksum: c688ad5b681f9afc93768cbbe28f196a (MD5) Previous issue date: 2008-06-01 Made available in DSpace on 2013-09-30T19:57:31Z (GMT). No. of bitstreams: 2 S0103-84782008000300037.pdf: 27770 bytes, checksum: c688ad5b681f9afc93768cbbe28f196a (MD5) S0103-84782008000300037.pdf.txt: 15992 bytes, checksum: c7b3f80dac41af9608ce1c6503ae85c2 (MD5) Previous issue date: 2008-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:04Z No. of bitstreams: 2 S0103-84782008000300037.pdf: 27770 bytes, checksum: c688ad5b681f9afc93768cbbe28f196a (MD5) S0103-84782008000300037.pdf.txt: 15992 bytes, checksum: c7b3f80dac41af9608ce1c6503ae85c2 (MD5) Made available in DSpace on 2014-05-20T13:14:04Z (GMT). No. of bitstreams: 2 S0103-84782008000300037.pdf: 27770 bytes, checksum: c688ad5b681f9afc93768cbbe28f196a (MD5) S0103-84782008000300037.pdf.txt: 15992 bytes, checksum: c7b3f80dac41af9608ce1c6503ae85c2 (MD5) Previous issue date: 2008-06-01 As síndromes paraneoplásicas compreendem um grupo diverso de alterações clínicas associadas a neoplasias e ocorrem em sítios distantes do tumor primário ou de suas metástases. As neuropatias paraneoplásicas são distúrbios raros em cães, mas representam morbidade significativa e servem como importantes indicadores diagnósticos e prognósticos. O presente trabalho relata a ocorrência de dois casos de neuropatia paraneoplásica em cães com mastocitoma, considerando a apresentação clínica, o diagnóstico e as formas de tratamento utilizadas. Paraneoplastic syndromes comprise a diverse group of clinical anomalies associated with neoplasias and occur in a location distant from the primary tumor or of your metastasis. Paraneoplastic neuropathy are rare disturbs in dogs, but represent significant morbidity and are useful as diagnostic and prognostic indicators. This work report the occurrence of two cases of paraneoplastic neuropathy in dogs with mast cell tumor, considering the clinical signs, diagnosis and treatment used. Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária Universidade de Franca Cirurgia e Anestesiologia Veterinária Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Clínica e Cirurgia Veterinária

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:50Z No. of bitstreams: 1 S0103-84782007000200047.pdf: 703823 bytes, checksum: cf6a305f56ec0172f892801e6760103a (MD5) Made available in DSpace on 2013-08-22T18:59:50Z (GMT). No. of bitstreams: 1 S0103-84782007000200047.pdf: 703823 bytes, checksum: cf6a305f56ec0172f892801e6760103a (MD5) Previous issue date: 2007-04-01 Made available in DSpace on 2013-09-30T19:57:14Z (GMT). No. of bitstreams: 2 S0103-84782007000200047.pdf: 703823 bytes, checksum: cf6a305f56ec0172f892801e6760103a (MD5) S0103-84782007000200047.pdf.txt: 16732 bytes, checksum: 4555dad33d97c389ec6acb7b5df66ed0 (MD5) Previous issue date: 2007-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:05Z No. of bitstreams: 2 S0103-84782007000200047.pdf: 703823 bytes, checksum: cf6a305f56ec0172f892801e6760103a (MD5) S0103-84782007000200047.pdf.txt: 16732 bytes, checksum: 4555dad33d97c389ec6acb7b5df66ed0 (MD5) Made available in DSpace on 2014-05-20T13:14:05Z (GMT). No. of bitstreams: 2 S0103-84782007000200047.pdf: 703823 bytes, checksum: cf6a305f56ec0172f892801e6760103a (MD5) S0103-84782007000200047.pdf.txt: 16732 bytes, checksum: 4555dad33d97c389ec6acb7b5df66ed0 (MD5) Previous issue date: 2007-04-01 Este trabalho tem como objetivo relatar a ocorrência de cinco casos de neoplasias de língua em cães. Os sinais clínicos mais observados foram ptialismo, halitose e hiporexia. Após biópsia excisional para exame histopatológico, os resultados revelaram dois casos de melanoma, um caso de histiocitoma, um caso de fibrossarcoma e um caso de mastocitoma grau II, sendo que neste o proprietário não autorizou qualquer forma de tratamento. O tratamento para os demais foi a glossectomia parcial e, no caso de fibrossarcoma, associou-se a quimioterapia. Dois animais apresentaram deiscência de sutura no pós-operatório, não havendo necessidade da realização de nova intervenção. em relação ao prognóstico, os pacientes com histiocitoma, fibrossarcoma e um com melanoma não apresentaram recidiva, nem metástase da doença 12 meses após a cirurgia. No outro caso de melanoma, o paciente apresentou metástase na pele e nos pulmões 30 dias após a ressecção cirúrgica. This paper is aimed at reporting five cases of neoplasms of the tongue in dogs. The clinical signs most observed were ptyalism, halitosis and hyporexia. After excisional biopsy the histological findings revealed two cases of melanoma, one case of histiocytoma, one case of fibrosarcoma and one case of mast cell tumor grade II, but in this case the owner didn't authorize any form of treatment. The treatments for the others cases were the partial glossectomy, and in the fibrosarcoma's case the chemotherapy was associated. Two animals had suture deiscencia in the post operatory, but in these cases it wasn't necessary another surgery. About the prognostic, the patients with histiocytoma, fibrosarcoma and one with melanoma didn't present cancer recurrence either metastasis 12 months after the surgery. But in another melanoma case the patient presented skin and lungs metastasis 30 day after surgery. Universidade Estadual Paulista Campus de Jaboticabal Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Campus de Jaboticabal Universidade Federal de Uberlândia Departamento de Medicina Veterinária Universidade Federal de Goiás (UFG) Escola de Veterinária Departamento de Medicina Veterinária Universidade Estadual Paulista Campus de Jaboticabal Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista Campus de Jaboticabal

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:22:44Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:40:37Z : No. of bitstreams: 1 2-s2.0-69649106473.pdf: 1981290 bytes, checksum: d956bdce38ae51c63976f0df6bfb7075 (MD5) Made available in DSpace on 2014-05-27T11:22:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-12-01 In this experiment, 18 hybrid steers, from the ages between 16 and 20 months, were submitted to the removal of the penis apical ligament to provoke a penis deviation. After passed 30 days, to be tested, the animals were put together to the females that were in heat. It was verified the formation of the ventral and right lateral penis deviation with incapacity of the copula. The bovines were submitted to the autologous implant from the one following superficial portion tendon from the superficial flexor fingers muscle, on the top of albuginea tunic, replacing the apical penis ligament removed. The material implanted was well tolerated, appearance a few inflammatory cells and formation of the fibrous conjunctive tissue, causing resistant adherence and capacity of sustaining the free penis extremity. The bovines, when were among the females that were in heat, did not show a penis deviation nor sexual behavior modification. The method revealed itself satisfactory and it can be indicated to correct ventral and right lateral penis deviation in bovines. Faculdade de Medicina Veterinária Universidade Federal de Uberlândia, Uberlândia-MG Faculdades Integradas do Planalto Central, Valparaíso de Goiás-GO Faculdade de Medicina Veterinária Universidade Federal de Goiás, Goiânia-GO Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista, Jaboticabal-SP Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista, Jaboticabal-SP

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:55:54Z No. of bitstreams: 1 S0102-09352007000300018.pdf: 210724 bytes, checksum: 6fc4aef0e8c5fab0d24c0bfe2d17726d (MD5) Made available in DSpace on 2013-08-22T18:55:54Z (GMT). No. of bitstreams: 1 S0102-09352007000300018.pdf: 210724 bytes, checksum: 6fc4aef0e8c5fab0d24c0bfe2d17726d (MD5) Previous issue date: 2007-06-01 Made available in DSpace on 2013-09-30T19:49:17Z (GMT). No. of bitstreams: 2 S0102-09352007000300018.pdf: 210724 bytes, checksum: 6fc4aef0e8c5fab0d24c0bfe2d17726d (MD5) S0102-09352007000300018.pdf.txt: 29989 bytes, checksum: f716c387fcf42f44075e9ea81714854f (MD5) Previous issue date: 2007-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:13:03Z No. of bitstreams: 2 S0102-09352007000300018.pdf: 210724 bytes, checksum: 6fc4aef0e8c5fab0d24c0bfe2d17726d (MD5) S0102-09352007000300018.pdf.txt: 29989 bytes, checksum: f716c387fcf42f44075e9ea81714854f (MD5) Made available in DSpace on 2014-05-20T15:13:03Z (GMT). No. of bitstreams: 2 S0102-09352007000300018.pdf: 210724 bytes, checksum: 6fc4aef0e8c5fab0d24c0bfe2d17726d (MD5) S0102-09352007000300018.pdf.txt: 29989 bytes, checksum: f716c387fcf42f44075e9ea81714854f (MD5) Previous issue date: 2007-06-01 Utilizaram-se 12 cães, machos, distribuídos em quatro grupos (G) experimentais, selecionados de acordo com o tempo de fluidoterapia com solução fisiológica 0,9%: G1 (sem fluidoterapia), G2 (uma hora de fluidoterapia antes da cisplatina), G3 (uma hora de fluidoterapia antes da cisplatina e uma hora após) e G4 (duas horas de fluidoterapia antes da cisplatina e uma após). Todos os animais receberam a cisplatina (70mg/m²), pela via intravenosa, sendo os ciclos de quimioterapia realizados em intervalos de três semanas, num total de três ciclos. O ondansetron (0,4mg/kg) foi administrado pela via intravenosa, a cada oito horas, no dia da quimioterapia e, a seguir, a cada 12 horas, por dois dias. O methimazole (40mg/kg) foi pela via oral, 30 minutos antes da cisplatina e quatro horas após. Avaliaram-se os parâmetros hematológicos, bioquímicos, urinários e dosagem de tiroxina e triiodotironina a cada sete dias até o término do experimento. Esse protocolo foi eficaz e seguro em cães que permaneceram sob fluidoterapia durante duas a três horas. Os animais que não receberam fluidoterapia e os que ficaram somente uma hora sob infusão intravenosa de solução fisiológica apresentaram alterações que resultaram em não-recomendação do protocolo. Twelve male dogs were divided in four experimental groups (G), which were selected according to the time of 0.9% saline fluid therapy: G1 (without saline therapy), G2 (an hour of saline therapy before receiving cisplatin), G3 (an hour of saline therapy before receiving cisplatin and one hour after) and G4 (two hours of saline therapy before receiving cisplatin and one hour after). All the animals received 70mg/m² cisplatin, via intravenous, and the chemotherapy cycles were accomplished in intervals of three weeks, in a total of three cycles. Ondansetron (0.4mg/kg) was administered via intravenous, every 8 hours, on the day of the chemotherapy and, from that, every 12 hours for two days. Methimazole (40mg/kg) was orally administered 30 minutes before the cisplatin injection and four hours after. The hematological, biochemical and urinary parameters and dosages of tiroxin and triiodotironine were evaluated every seven days until the end of the experiment. This protocol was effective and safe in the animals that stayed for a period of two or three hours receiving saline therapy, because they did not present clinical and laboratory alterations of the use of chemotherapy. The animals that did not receive saline therapy and those that received infusion of physiologic solution via IV only during one hour presented alterations that made unfeasible the use of this protocol. UNIMAR Faculdade de Medicina Veterinária UNESP Faculdade de Ciências Agrárias e Veterinárias UNESP Faculdade de Ciências Agrárias e Veterinárias

O fator de crescimento do endotelio vascular (VEGF) e um dos mais especificos reguladores da angiogenese e da linfangiogenese tumoral, alem de influenciar na tumorigenese mediante ativacao de um circuito de sinalizacao autocrina que permite que as celulas neoplasicas estimulem seu proprio crescimento. O objetivo desse estudo foi investigar os niveis sericos e a imunomarcacao do VEGF nos linfomas multicentricos caninos e correlacionar esses parâmetros com fatores prognosticos da neoplasia. Foram avaliados 16 caes, sendo oito clinicamente sadios e oito com diagnostico de linfoma multicentrico. Os animais foram submetidos a coleta de sangue para mensuracao da concentracao serica do VEGF e biopsia de linfonodo para avaliacao da imunomarcacao do VEGF. O escore de imunomarcacao do VEGF foi superior (p=0,0003) nos linfonodos de caes com linfoma multicentrico (8,50±2,33) em comparacao ao escore dos linfonodos de caes sadios (1,87±1,80). Nao houve diferenca significativa entre as concentracoes sericas do VEGF de caes sadios e de caes com linfoma (p=0,08). Imunofenotipo, estadiamento clinico e grau de malignidade influenciaram na sobrevida dos caes com linfoma. Os resultados obtidos permitiram concluir que o VEGF esta expresso em quantidades elevadas nos linfonodos de caes com linfoma multicentrico, podendo ser responsavel pelo crescimento, sobrevivencia e migracao das celulas tumorais.

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:22:19Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:40:15Z : No. of bitstreams: 1 2-s2.0-67249144132.pdf: 671710 bytes, checksum: a9206d77f990118d5d22a19ea0341317 (MD5) Made available in DSpace on 2014-05-27T11:22:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-01 The osteosarcoma (OSA) is one of the most common malignant tumors of dogs. Large and giant-breed dogs are affected and the mean age of these dogs is about 7 years. The tumor usually involves the metaphyses of long bones and the treatment is radical amputation and chemotherapy with cisplatin. The therapy of neoplasia located in pelvis is difficult and usually don't accept by owners. This report describes the incidence of primary osteosarcoma in pelvis of dogs, during a period of fourteen months. Of the eight animals taken care with this neoplasia, a bigger frequency in the dogs of the race Rottweiler and German Pastor was observed. Amongst the bones that compose animal's pelvis was observed greater osteosarcoma incidence in ileum (6 cases). Lameness, functional impotence of pelvic member and pain had been the main observed clinical signals. In seven cases was found advanced involvement osseous, mainly, for lyses of the cortical. All the animals had been submitted to the euthanasia for not presenting possibility of surgical treatment with safety margin. Also one was taken in consideration for this decision to the clinical condition of the patients, the possibilities to confer improvement in the quality of life of the dogs and the option of the owners' front to the prognostic. Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista, Via de Acesso Prof. Paulo Donato Castelani, sn, 14870-000 - Jaboticabal - SP Médico Veterinário Autônomo Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista, Via de Acesso Prof. Paulo Donato Castelani, sn, 14870-000 - Jaboticabal - SP