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15 results on '"Carlos Garcia-Pagan, Juan"'

1. SAT-123 Evaluation of portal hemodynamics after etiological factor removal and persistence of varices in patients with an HVPG

Author

Olivas Alberch, Pol, Soler, Alexandre, Téllez, Luis, Carrión, Jose A., Alvarado-Tapias, Edilmar, Alberto Ferrusquía, José, Lens, Sabela, Guerrero, Antonio, Àngels Falgà, M., Vizcarra, Pamela, Orts, Lara, Perez, Valeria, Shalaby, Sarah, Baiges, Anna, Turon, Fanny, Carlos García-Pagán, Juan, Ángeles García-Criado, Maria, and Hernández-Gea, Virginia

Published
2024
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5. Congenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): An International Observational Study

Author

Baiges, Anna, Turon, Fanny, Simon-Talero, Macarena, Tasayco, Stephanie, Bueno, Javier, Zekrini, Kamal, Plessier, Aurelie, Franchi-Abella, Stephanie, Guerin, Florent, Mukund, Amar, Eapen, CE, Goel, Ashish, Shyamkumar, Nidugala Keshava, Coenen, Sandra, De Gottardi, Andrea, Majumdar, Avik, Onali, Simona, Shukla, Akash, Jose Carrilho, Flair, Nacif, Lucas, Primignani, Massimo, Tosetti, Giulia, La Mura, Vicenzo, Nevens, Frederik, Witters, Peter, Tripathi, Dhiraj, Tellez, Luis, Martinez, Javier, Alvarez-Navascues, Carmen, Fraile Lopez, Miguel Lopez, Procopet, Bogdan, Piscaglia, Fabio, de Koning, Barbara, Llop, Elba, Romero-Cristobal, Mario, Tjwa, Eric, Monescillo-Francia, Alberto, Senzolo, Marco, Perez-LaFuente, Mercedes, Segarra, Antonio, Sarin, Shiv Kumar, Hernandez-Gea, Virginia, Patch, David, Laleman, Wim, Hartog, Hermien, Valla, Dominique, Genesca, Joan, Carlos Garcia-Pagan, Juan, Garcia-Criado, Angeles, Darnell, Anna, Belmonte, Ernest, Ferrusquia-Acosta, Jose, Magaz, Marta, Vidal-Gonzalez, Judit, Horia, Stefanescu, Nicoara-Farcau, Oana, Joseph, Philip, Zachariah, Uday, Moses, Vinu, Mammen, Suraj, Ahmed, Munawwar, Koshy, George, Eapen, Anu, Sajith, KG, Vyas, FL, Raju, RS, Rymbai, Manbha L, Arulkumar, S, Ramachandran, Jeyamani, Elias, Elwyn, Baiges A., Turon F., Simon-Talero M., Tasayco S., Bueno J., Zekrini K., Plessier A., Franchi-Abella S., Guerin F., Mukund A., Eapen C.E., Goel A., Shyamkumar N.K., Coenen S., De Gottardi A., Majumdar A., Onali S., Shukla A., Carrilho F.J., Nacif L., Primignani M., Tosetti G., La Mura V., Nevens F., Witters P., Tripathi D., Tellez L., Martinez J., Alvarez-Navascues C., Fraile Lopez M.L., Procopet B., Piscaglia F., de Koning B., Llop E., Romero-Cristobal M., Tjwa E., Monescillo-Francia A., Senzolo M., Perez-LaFuente M., Segarra A., Sarin S.K., Hernandez-Gea V., Patch D., Laleman W., Hartog H., Valla D., Genesca J., Garcia-Pagan J.C., Gastroenterology & Hepatology, Pediatrics, and Surgery

Subjects
0301 basic medicine, Male, Vascular Malformations, medicine.medical_treatment, International Cooperation, Liver transplantation, 0302 clinical medicine, Malalties hereditàries, Hepatopulmonary syndrome, 610 Medicine & health, Child, Hepatic encephalopathy, Portal Vein, Malalties del fetge, Liver Neoplasms, vascular diseases of the liver, Middle Aged, Abernethy, Child, Preschool, 030211 gastroenterology & hepatology, Female, medicine.symptom, Genetic diseases, Adult, medicine.medical_specialty, Adenoma, Adolescent, Hypertension, Pulmonary, Asymptomatic, 03 medical and health sciences, Young Adult, extrahepatic portosytemic shunt, medicine, Humans, Liver diseases, Aged, Retrospective Studies, Abernethy Malformation, Hepatology, business.industry, Infant, Retrospective cohort study, medicine.disease, Pulmonary hypertension, Surgery, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, Hepatic Encephalopathy, Congenital malformation, Portosystemic shunt, business, Hepatopulmonary Syndrome
Abstract

Contains fulltext : 220051.pdf (Publisher’s version ) (Closed access) Congenital extrahepatic portosystemic shunt (CEPS) or Abernethy malformation is a rare condition in which splanchnic venous blood bypasses the liver draining directly into systemic circulation through a congenital shunt. Patients may develop hepatic encephalopathy (HE), pulmonary hypertension (PaHT), or liver tumors, among other complications. However, the actual incidence of such complications is unknown, mainly because of the lack of a protocolized approach to these patients. This study characterizes the clinical manifestations and outcome of a large cohort of CEPS patients with the aim of proposing a guide for their management. This is an observational, multicenter, international study. Sixty-six patients were included; median age at the end of follow-up was 30 years. Nineteen patients (28%) presented HE. Ten-, 20-, and 30-year HE incidence rates were 13%, 24%, and 28%, respectively. No clinical factors predicted HE. Twenty-five patients had benign nodular lesions. Ten patients developed adenomas (median age, 18 years), and another 8 developed HCC (median age, 39 years). Of 10 patients with dyspnea, PaHT was diagnosed in 8 and hepatopulmonary syndrome in 2. Pulmonary complications were only screened for in 19 asymptomatic patients, and PaHT was identified in 2. Six patients underwent liver transplantation for hepatocellular carcinoma or adenoma. Shunt closure was performed in 15 patients with improvement/stability/cure of CEPS manifestations. Conclusion: CEPS patients may develop severe complications. Screening for asymptomatic complications and close surveillance is needed. Shunt closure should be considered both as a therapeutic and prophylactic approach.

Published
2018

6. PS-018-Paroxysmal nocturnal hemoglobinuria and Budd Chiari syndrome: Impact of Eculizumab therapy on survival and liver outcome in 54 patients: A multicentric valdig study

Author

Plessier, Aurélie, primary, René, Bun, additional, Baiges, Anna, additional, Shukla, Akash, additional, carlos, garcia pagan juan, additional, Valla, Dominique, additional, Emmanuelle, Deraucourt, additional, Ollivier-Hourmand, Isabelle, additional, Cervoni, Jean Paul, additional, Ledinghen, Victor De, additional, Zoubida, Tazi, additional, baptiste, nousbaum jean, additional, christophe, Bureau, additional, Silvain, Christine, additional, Olivier, Tournilhac, additional, mathieu, Gerfaud valentin, additional, Durand, François, additional, Socie, Gerard, additional, Goria, Odile, additional, luis, Tellez, additional, Albillos, Agustin, additional, Gioia, Stefania, additional, Riggio, Oliviero, additional, Audrey, Payance, additional, Gottardi, Andrea De, additional, Rautou, PE, additional, Regis, Peffault de la tour, additional, nathalie, gault, additional, and Flore, Sicre, additional

Published
2019
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7. FRI-439-Factor V and VIII may predict the risk of recurrent splanchnic thrombosis in patients with non-cirrhotic chronic portal vein thrombosis of local and idiopathic etiology not receiving anticoagulation

Author

Procopet, Bogdan, primary, Silva-Junior, Gilberto, additional, Llop, Elba, additional, luis, Tellez, additional, Darnell, Anna, additional, García-Criado, Ángeles, additional, Turon, Fanny, additional, Baiges, Anna, additional, Magaz, Marta, additional, Panero, José Luis Calleja, additional, Albillos, Agustin, additional, Reverter, Juan Carlos, additional, Bosch, Jaume, additional, Hernandez-Gea, Virginia, additional, and carlos, garcia pagan juan, additional

Published
2019
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8. SAT-079-Respiratory infection in patients with cirrhosis and acute variceal bleeding on antibiotic prophylaxis: A multicenter observational study of 2138 patients

Author

Martinez, Javier, primary, luis, Tellez, additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez, Luis, additional, Silva-Junior, Gilberto, additional, Genesca, Joan, additional, christophe, Bureau, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose María, additional, Castellote, José, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferreira, Carlos Noronha, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodriguez, Manuel, additional, Ferlitsch, Prof. Dr. Arnulf, additional, Mundi, Jose Luis, additional, Granbæk, Henning, additional, Hernandez-Guerra, Manuel, additional, Sassatelli, Romanno, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan, additional, Romero-gómez, Manolo, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Panero, José Luis Calleja, additional, Jansen, Christian, additional, Robic, Marie Angele, additional, Conejo, Irene, additional, Catalina, Maria-Vega, additional, Rudler, Marika, additional, Bañares, Rafael, additional, Alvarado, Edilmar, additional, Trebicka, Jonel, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Torres, Ferran, additional, Bosch, Jaime, additional, Carlos, Garcia Pagan Juan, additional, and Albillos, Agustin, additional

Published
2019
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11. PS-017-Long-term impact of sustained virological response on systemic and pulmonary hemodynamics in HCV-cirrhotic patients with portal hypertension

Author

Lens, Sabela, primary, Alvarado, Edilmar, additional, Blanco, Isabel, additional, Mariño, Zoe, additional, Orizaga, Tanya, additional, Ibañez, Luis, additional, Fortea, Jose Ignacio, additional, Torras, Xavier, additional, Baiges, Anna, additional, Turon, Fanny, additional, Hernandez-Gea, Virginia, additional, Bañares, Rafael, additional, Puente, Angela, additional, Bosch, Jaume, additional, Barbera, Joan Albert, additional, Villanueva, Candid, additional, Forns, Xavier, additional, and Carlos, Garcia Pagan Juan, additional

Published
2019
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12. NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats.

Author

Angermayr, Bernhard, Fernandez, Mercedes, Mejias, Marc, Gracia-Sancho, Jorge, Carlos Garcia-Pagan, Juan, and Bosch, Jaime

Subjects
NEOVASCULARIZATION, HYPERTENSION, LABORATORY rats, VASCULAR endothelial growth factors, HYPEREMIA, HEMODYNAMICS
Abstract

Background: Recent studies have shown the presence of vascular endothelial growth factor (VEGF)-dependent splanchnic angiogenesis in experimental models of portal hypertension, and the role of such neovascularisation on the development of both portosystemic collaterals and hyperdynamic splanchrtic circulation. However, the mechanisms modulating angiogenesis in portal hypertension are unknown. Experimental evidence indicates that NAD(P)H oxidase is required for VEGF-induced angiogenesis. Interestingly, we have recently shown that splanchnic NAD(P)H oxidase activity is significantly increased in portal hypertensive rats. Therefore, it could be possible that activated NAD(P)H oxidases modulate angiogenesis in portal hypertension. Aim: To determine the effects of chronic NAD(P)H oxidase inhibition on angiogenesis and splanchnic haemodynamics in portal hypertensive rats. Methods: Partial portal vein-ligated and sham-operated rats were treated with the NAD(P)H oxidase inhibitor apocynin, or with vehicle for 5 days. Then, the expression of angiogenesis markers (western blotting), the formation of portosystemic collaterals (radioactive microspheres) and the production of superoxide anion (lucigenin-enhanced chemiluminescence) were determined. Mean arterial pressure, portal pressure, and superior mesenteric arterial blood flow and resistance were also measured. Results: In portal hypertensive rats, NAD(P)H oxidase blockade significantly decreased portosystemic collateral formation, and superior mesenteric arterial flow. It also reduced the splanchnic expression of VEGF, VEGF receptor-2 and CD31, and attenuated the increased production of superoxide, compared with vehicle. Conclusions: NAD(P)H oxidase plays an important role in experimental portal hypertension, modulating splanchnic angiogenesis, the formation of portosystemic collaterals and the development of splanchnic hyperdynamic circulation. These results suggest that NAD(P)H oxidase may represent a new target in the treatment of portal hypertension. [ABSTRACT FROM AUTHOR]

Published
2007
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13. Early-TIPS improves survival in high-risk variceal bleeders. Results of a Multicenter Variceal Bleeding Observational Study

Author

Hernandez-Gea, Virginia, Procopet, Bogdan, Giraldez, Alvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibanez Samaniego, Luis, Silva-Junior, Gilberto, Albillos, Agustin, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Maria Palazon, Jose, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Canete, Nuria, Navascues, Carmen, Ferlitsch, Arnulf, Luis Mundi, Jose, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Manuel Romero-Gómez, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Torres, Ferran, Krag, Aleksander, Bosch, Jaime, and Carlos Garcia-Pagan, Juan

15. Abdominal surgery in patients with chronic noncirrhotic extrahepatic portal vein obstruction: A multicenter retrospective study.

Author

Elkrief L, Denecheau-Girard C, Magaz M, Praktiknjo M, Colucci N, Ollivier-Hourmand I, Dumortier J, Simon Talero M, Tellez L, Artru F, Meszaros M, Verhelst X, Tabchouri N, Beires F, Andaluz I, Leo M, Diekhöner M, Dokmak S, Fundora Y, Vidal-Gonzalez J, Toso C, Plessier A, Carlos Garcia Pagan J, and Rautou PE

Abstract

Background and Aims: In patients with noncirrhotic chronic extrahepatic portal vein obstruction (EHPVO), data on the morbimortality of abdominal surgery are scarce., Approach and Results: We retrospectively analyzed the charts of 76 patients (78 interventions) with EHPVO undergoing abdominal surgery within the Vascular Disease Interest Group network. Fourteen percent of the patients had ≥1 major bleeding (unrelated to portal hypertension) and 21% had ≥1 Dindo-Clavien grade ≥3 postoperative complications within 1 month after surgery. Fifteen percent had ≥1 portal hypertension-related complication within 3 months after surgery. Three patients died within 12 months after surgery. An unfavorable outcome (ie, ≥1 abovementioned complication or death) occurred in 37% of the patients and was associated with a history of ascites and with nonwall, noncholecystectomy surgical intervention: 17% of the patients with none of these features had an unfavorable outcome, versus 48% and 100% when one or both features were present, respectively. We then compared 63/76 patients with EHPVO with 126 matched (2:1) control patients without EHPVO but with similar surgical interventions. As compared with control patients, the incidence of major bleeding ( p <0.001) and portal hypertension-related complication ( p <0.001) was significantly higher in patients with EHPVO, but not that of grade ≥3 postoperative complications nor of death. The incidence of unfavorable postoperative outcomes was significantly higher in patients with EHPVO than in those without (33% vs. 18%, p =0.01)., Conclusions: Patients with EHPVO are at high risk of major perioperative or postoperative bleeding and postoperative complications, especially in those with ascites or undergoing surgery other than wall surgery or cholecystectomy., (Copyright © 2024 American Association for the Study of Liver Diseases.)

Published
2024
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