1. Vitamin D Status in Pediatric and Young Adult Cystic Fibrosis Patients. Are the New Recommendations Effective?
- Author
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Carmen Mangas-Sánchez, María Garriga-García, María Juliana Serrano-Nieto, Ruth García-Romero, Marina Álvarez-Beltrán, Elena Crehuá-Gaudiza, Rosana Muñoz-Codoceo, Lucrecia Suárez-Cortina, Saioa Vicente-Santamaría, Cecilia Martínez-Costa, Juan José Díaz-Martin, Carlos Bousoño-García, and David González-Jiménez
- Subjects
vitamin D ,cystic fibrosis ,multicenter study ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Introduction: In recent years, guidelines for vitamin D supplementation have been updated and prophylactic recommended doses have been increased in patients with cystic fibrosis (CF). Objective: To evaluate safety and efficacy of these new recommendations. Results: Two cohorts of pancreatic insufficient CF patients were compared before (cohort 1: 179 patients) and after (cohort 2: 71 patients) American CF Foundation and European CF Society recommendations were published. Cohort 2 patients received higher Vitamin D doses: 1509 (1306–1711 95% CI) vs 1084 (983–1184 95% CI) IU/Day (p < 0.001), had higher 25 OH vitamin D levels: 30.6 (27.9–33.26 95% CI) vs. 27.4 (25.9–28.8 95% CI) ng/mL (p = 0.028), and had a lower prevalence of insufficient vitamin D levels (p = 0.011). Adjusted by confounding factors, patients in cohort 1 had a higher risk of vitamin D insufficiency: OR 2.23 (1.09–4.57 95% CI) (p = 0.028). Conclusion: After the implementation of new guidelines, CF patients received higher doses of vitamin D and a risk of vitamin D insufficiency decreased. Despite this, almost a third of CF patients still do not reach sufficient serum calcidiol levels.
- Published
- 2021
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