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1. Better prognosis in females with severe COVID-19 pneumonia: possible role of inflammation as potential mediator

Author

Bacca, Erica, Bedini, Andrea, Borghi, Vanni, Burastero, Giulia, Carli, Federica, Ciusa, Giacomo, Corradi, Luca, Di Gaetano, Margherita, Faltoni, Matteo, Franceschi, Giacomo, Orlando, Gabriella, Pellegrino, Francesco, Puzzolante, Cinzia, Raimondi, Alessandro, Santoro, Antonella, Tutone, Marco, Yaacoub, Dina, Andreotti, Alberto, Biagioni, Emanuela, Bondi, Filippo, Busani, Stefano, Chierego, Giovanni, Scotti, Marzia, Serio, Lucia, Bellinazzi, Caterina, Borella, Rebecca, De Biasi, Sara, De Gaetano, Anna, Fidanza, Lucia, Gibellini, Lara, Iannone, Anna, Lo Tartaro, Domenico, Mattioli, Marco, Paolini, Annamaria, Fogliani, Rossella, Righini, Grazia, Lugli, Mario, Mussini, Cristina, Cozzi-Lepri, Alessandro, Menozzi, Marianna, Meschiari, Marianna, Franceschini, Erica, Rogati, Carlotta, Cuomo, Gianluca, Iadisernia, Vittorio, Volpi, Sara, Milic, Jovana, Tonelli, Roberto, Brugioni, Lucio, Pietrangelo, Antonello, Girardis, Massimo, Cossarizza, Andrea, Clini, Enrico, and Guaraldi, Giovanni

Published
2021
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3. Tocilizumab in patients with severe COVID-19: a retrospective cohort study

Author

Guaraldi, Giovanni, Meschiari, Marianna, Cozzi-Lepri, Alessandro, Milic, Jovana, Tonelli, Roberto, Menozzi, Marianna, Franceschini, Erica, Cuomo, Gianluca, Orlando, Gabriella, Borghi, Vanni, Santoro, Antonella, Di Gaetano, Margherita, Puzzolante, Cinzia, Carli, Federica, Bedini, Andrea, Corradi, Luca, Fantini, Riccardo, Castaniere, Ivana, Tabbì, Luca, Girardis, Massimo, Tedeschi, Sara, Giannella, Maddalena, Bartoletti, Michele, Pascale, Renato, Dolci, Giovanni, Brugioni, Lucio, Pietrangelo, Antonello, Cossarizza, Andrea, Pea, Federico, Clini, Enrico, Salvarani, Carlo, Massari, Marco, Viale, Pier Luigi, and Mussini, Cristina

Published
2020
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4. A Machine Learning Approach to Predict Weight Change in ART-Experienced People Living With HIV

Author

Motta, Federico, primary, Milic, Jovana, additional, Gozzi, Licia, additional, Belli, Michela, additional, Sighinolfi, Laura, additional, Cuomo, Gianluca, additional, Carli, Federica, additional, Dolci, Giovanni, additional, Iadisernia, Vittorio, additional, Burastero, Giulia, additional, Mussini, Cristina, additional, Missier, Paolo, additional, Mandreoli, Federica, additional, and Guaraldi, Giovanni, additional

Published
2023
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6. Premature Decline of Serum Total Testosterone in HIV-Infected Men in the HAART-Era

Author

Rochira, Vincenzo, Zirilli, Lucia, Orlando, Gabriella, Santi, Daniele, Brigante, Giulia, Diazzi, Chiara, Carli, Federica, Carani, Cesare, and Guaraldi, Giovanni

Subjects
Clinical Research, Infectious Diseases, Contraception/Reproduction, Aging, HIV/AIDS, Nutrition, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adolescent, Adult, Aged, Antiretroviral Therapy, Highly Active, Cohort Studies, HIV Infections, Humans, Hypogonadism, Linear Models, Male, Middle Aged, Penile Erection, Testosterone, Young Adult, General Science & Technology
Abstract

BackgroundTestosterone (T) deficiency remains a poorly understood issue in men with Human Immunodeficiency Virus (HIV). We investigated the gonadal status in HIV-infected men in order to characterize T deficiency and to identify predictive factors for low serum T.Methodology/principal findingsWe performed a cross-sectional, observational study on 1325 consecutive HIV male outpatients, most of them having lipodystrophy. Serum total T

Published
2011

8. Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV.

Author

Guaraldi, Giovanni, Milic, Jovana, Bacchi, Elena, Carli, Federica, Menozzi, Marianna, Franconi, Iacopo, Raimondi, Alessandro, Ciusa, Giacomo, Masi, Valentina, Belli, Michela, Guaraldi, Stefano, Aprile, Emanuele, Mancini, Maria, Mussini, Cristina, Lake, Jordan E., and Erlandson, Kristine M.

Subjects
WEIGHT gain, HIV-positive persons, INTEGRASE inhibitors, BODY mass index, HUMAN reproductive technology, CD4 lymphocyte count, PHYSICAL activity, SMOKING cessation
Abstract

Background: Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up. Methods: In an observational cohort study from 2007 to 2019 at Modena HIV Metabolic Clinic, Italy, ART-experienced but INSTI-naive PLWH were grouped as INSTI-switchers vs non-INSTI. Groups were matched for sex, age, baseline BMI and follow-up duration. Significant WG was defined as an increase of ≥5% from 1st visit weight over follow-up. PAFs and 95% CIs were estimated to quantify the proportion of the outcome that could be avoided if the risk factors were not present. Results: 118 PLWH switched to INSTI and 163 remained on current ART. Of 281 PLWH (74.3% males), mean follow-up was 4.2 years, age 50.3 years, median time since HIV diagnosis 17.8 years, CD4 cell count 630 cells/µL at baseline. PAF for weight gain was the greatest for high BMI (45%, 95% CI: 27–59, p < 0.001), followed by high CD4/CD8 ratio (41%, 21–57, p < 0.001) and lower physical activity (32%, 95% CI 5–52, p = 0.03). PAF was not significant for daily caloric intake (−1%, −9-13, p = 0.45), smoking cessation during follow-up (5%, 0–12, p = 0.10), INSTI switch (11%, −19-36; p = 0.34). Conclusions: WG in PLWH on ART is mostly influenced by pre-existing weight and low physical activity, rather than switch to INSTI. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Bone Mineral Density and Trabecular Bone Score Changes throughout Menopause in Women with HIV.

Author

Milic, Jovana, Renzetti, Stefano, Morini, Denise, Motta, Federico, Carli, Federica, Menozzi, Marianna, Cuomo, Gianluca, Mancini, Giuseppe, Simion, Mattia, Romani, Federico, Spadoni, Anna, Baldisserotto, Irene, Barp, Nicole, Diazzi, Chiara, Mussi, Chiara, Mussini, Cristina, Rochira, Vincenzo, Calza, Stefano, and Guaraldi, Giovanni

Subjects
MENOPAUSE, BONE density, BONE health, POSTMENOPAUSE, CANCELLOUS bone, PHASE transitions, HIV
Abstract

Objective: The objectives of this study were to describe the trajectories of bone mineral density (BMD) and trabecular bone score (TBS) changes throughout pre-menopause (reproductive phase and menopausal transition) and post-menopause (early and late menopause) in women with HIV (WWH) undergoing different antiretroviral therapies (ARTs) and explore the risk factors associated with those changes. Methods: This was an observational longitudinal retrospective study in WWH with a minimum of two DEXA evaluations comprising BMD and TBS measurements, both in the pre-menopausal and post-menopausal periods. Menopause was determined according to the STRAW+10 criteria, comprising four periods: the reproductive period, menopausal transition, and early- and late-menopausal periods. Mixed-effects models were fitted to estimate the trajectories of the two outcomes (BMD and TBS) over time. Annualized lumbar BMD and TBS absolute and percentage changes were calculated in each STRAW+10 time window. A backward elimination procedure was applied to obtain the final model, including the predictors that affected the trajectories of BMD or TBS over time. Results: A total of 202 WWH, all Caucasian, were included. In detail, 1954 BMD and 195 TBS data were analyzed. The median number of DEXA evaluations per woman was 10 (IQR: 7, 12). The median observation periods per patient were 12.0 years (IQR = 8.9–14.4) for BMD and 6.0 years (IQR: 4.3, 7.9) for TBS. The prevalence of osteopenia (63% vs. 76%; p < 0.001) and osteoporosis (16% vs. 36%; p < 0.001) increased significantly between the pre-menopausal and post-menopausal periods. Both BMD (1.03 (±0.14) vs. 0.92 (±0.12) g/cm2; p < 0.001) and TBS (1.41 (IQR: 1.35, 1.45) vs. 1.32 (IQR: 1.28, 1.39); p < 0.001) decreased significantly between the two periods. The trend in BMD decreased across the four STRAW+10 periods, with a slight attenuation only in the late-menopausal period when compared with the other intervals. The TBS slope did not significantly change throughout menopause. The delta mean values of TBS in WWH were lower between the menopausal transition and reproductive period compared with the difference between menopause and menopausal transition. Conclusions: Both BMD and TBS significantly decreased over time. The slope of the change in BMD and TBS significantly decreased in the menopausal transition, suggesting that this period should be considered by clinicians as a key time during which to assess bone health and modifiable risk factors in WWH. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Sex Differences in People Aging With HIV

Author

Brañas, Fátima, Sánchez-Conde, Matilde, Carli, Federica, Menozzi, Marianna, Raimondi, Alessandro, Milic, Jovana, Franconi, Jacopo, Cuomo, Gianluca, Mussini, Cristina, Moreno, Santiago, and Guaraldi, Giovanni

Published
2020
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12. Antiretroviral therapy in geriatric HIV patients: the GEPPO cohort study

Author

Nozza, Silvia, Malagoli, Andrea, Maia, Lilian, Calcagno, Andrea, Focà, Emanuele, De Socio, Giuseppe, Piconi, Stefania, Orofino, Giancarlo, Cattelan, Anna Maria, Celesia, Benedetto Maurizio, Gervasi, Elena, Guaraldi, Giovanni, Nozza, Silvia, Castagna, Antonella, Poli, Andrea, Galizzi, Nadia, Guaraldi, Giovanni, Carli, Federica, Malagoli, Andrea, Calcagno, Andrea, Di Perri, Giovanni, Bonora, Stefano, Montrucchio, Chiara, Focà, Emanuele, Castelli, Francesco, Magro, Paola, Roldan, Eugenia Quiros, De Socio, Giuseppe Vittorio, Marinello, Serena, Piconi, Stefania, Orofino, Giancarlo, Farenga, Mariana, Cattela, Anna Maria, Marinello, Serena, Celesia, Benedetto Maurizio, Marino, Andrea, Cacopardo, Bruno, Galli, Massimo, Riva, Agostino, Morena, Valeria, and Gervasi, Elena

Published
2017
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13. Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Author

MAGNIFICENT Consortium, INSIGHT, Swiss HIV Cohort Study, Rotger, Margalida, Glass, Tracy R., Junier, Thomas, Lundgren, Jens, Neaton, James D., Poloni, Estella S., van 't Wout, Angélique B., Lubomirov, Rubin, Colombo, Sara, Martinez, Raquel, Rauch, Andri, Günthard, Huldrych F., Neuhaus, Jacqueline, Wentworth, Deborah, van Manen, Danielle, Gras, Luuk A., Schuitemaker, Hanneke, Albini, Laura, Torti, Carlo, Jacobson, Lisa P., Li, Xiuhong, Kingsley, Lawrence A., Carli, Federica, Guaraldi, Giovanni, Ford, Emily S., Sereti, Irini, Hadigan, Colleen, Martinez, Esteban, Arnedo, Mireia, Egaña-Gorroño, Lander, Gatell, Jose M., Law, Matthew, Bendall, Courtney, Petoumenos, Kathy, Rockstroh, Jürgen, Wasmuth, Jan-Christian, Kabamba, Kabeya, Delforge, Marc, De Wit, Stephane, Berger, Florian, Mauss, Stefan, de Paz Sierra, Mariana, Losso, Marcelo, Belloso, Waldo H., Leyes, Maria, Campins, Antoni, Mondi, Annalisa, De Luca, Andrea, Bernardino, Ignacio, Barriuso-Iglesias, Mónica, Torrecilla-Rodriguez, Ana, Gonzalez-Garcia, Juan, Arribas, José R., Fanti, Iuri, Gel, Silvia, Puig, Jordi, Negredo, Eugenia, Gutierrez, Mar, Domingo, Pere, Fischer, Julia, Fätkenheuer, Gerd, Alonso-Villaverde, Carlos, Macken, Alan, Woo, James, McGinty, Tara, Mallon, Patrick, Mangili, Alexandra, Skinner, Sally, Wanke, Christine A., Reiss, Peter, Weber, Rainer, Bucher, Heiner C., Fellay, Jacques, Telenti, Amalio, and Tarr, Philip E.

Published
2013
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15. Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV

Author

Guaraldi, Giovanni, Milic, Jovana, Bacchi, Elena, Carli, Federica, Menozzi, Marianna, Franconi, Iacopo, Raimondi, Alessandro, Ciusa, Giacomo, Masi, Valentina, Belli, Michela, Guaraldi, Stefano, Aprile, Emanuele, Mancini, Maria, Mussini, Cristina, Lake, Jordan E, and Erlandson, Kristine M

Subjects
integrase inhibitors, population attributable fractions, physical activity, weight gain, people living with HIV
Published
2022

19. Peritoneal dialysis in the time of coronavirus disease 2019

Author

Alfano, Gaetano, Fontana, Francesco, Ferrari, Annachiara, Guaraldi, Giovanni, Mussini, Cristina, Magistroni, Riccardo, Cappelli, Gianni, Bacca, Erica, Bedini, Andrea, Borghi, Vanni, Burastero, Giulia, Carli, Federica, Ciusa, Giacomo, Corradi, Luca, Cuomo, Gianluca, Digaetano, Margherita, Dolci, Giovanni, Faltoni, Matteo, Fantini, Riccardo, Franceschi, Giacomo, Franceschini, Ericad, Iadisernia, Vittorio, Larnõ, Damiano, Menozzi, Marianna, Meschiari, Marianna, Milic, Jovana, Orlando, Gabriella, Pellegrino, Francesco, Raimondi, Alessandro, Rogati, Carlotta, Santoro, Antonella, Tonelli, Roberto, Tutone, Marco, Volpi, Sara, Yaacoub, Dina, Aten, G., Marco, Ballestri, Mori, Giacomo, Girardis, Massimo, Andreotti, Alberto, Biagioni, Emanuela, Bondi, Filippo, Busani, Stefano, Chierego, Giovanni, Scotti, Marzia, Serio, Lucia, Cossarizza, Andrea, Bellinazzi, Caterina, Borella, Rebecca, de Biasi, Sara, de Gaetano, Anna, Fidanza, Lucia, Gibellini, Lara, Iannone, Anna, Lo Tartaro, Domenico, Mattioli, Marco, Nasi, Milena, Paolini, Annamariag, and Pinti, Marcello

Subjects
peritoneal dialysis, SARS-CoV-2, coronavirus, dialysis, telemedicine, Editorial Comments, COVID
Abstract

In the current setting of global containment, peritoneal dialysis (PD) and home haemodialysis are the best modalities of renal replacement therapy (RRT) to reduce the rate of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Considering the shorter and easier training programme of PD compared to home haemodialysis, PD appears a practical solution for patients with end-stage renal disease to reduce the risk of hospital-acquired infection. PD offers the advantage of minimizing the risk of viral transmission through interpersonal contact that commonly occurs during the haemodialysis session and while travelling from home to the haemodialysis facility using public transport services. To overcome barriers to health care access due to the containment measures for this emerging disease, telemedicine is a useful and reliable tool for delivering health care without exposing patients to the risk of contact. However, novel issues including handling of potentially infected dialysate, caregivers’ infectious risk and adequacy of PD in critically ill patients with acute respiratory distress syndrome remain to be clarified. In conclusion, PD should be preferred to the other modalities of RRT during the coronavirus disease 2019 (COVID-19) outbreak because it can be a solution to cope with the increased number of infected patients worldwide.

Published
2020

20. Coronary Aging in HIV-Infected Patients

Author

Guaraldi, Giovanni, Zona, Stefano, Alexopoulos, Nikolaos, Orlando, Gabriella, Carli, Federica, Ligabue, Guido, Fiocchi, Federica, Lattanzi, Antonella, Rossi, Rosario, Modena, Maria Grazia, Esposito, Roberto, Palella, Frank, and Raggi, Paolo

Published
2009

21. Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational Study

Author

Franceschini, Erica, Cozzi-Lepri, Alessandro, Santoro, Antonella, Bacca, Erica, Lancellotti, Guido, Menozzi, Marianna, Gennari, William, Meschiari, Marianna, Bedini, Andrea, Orlando, Gabriella, Puzzolante, Cinzia, Digaetano, Margherita, Milic, Jovana, Codeluppi, Mauro, Pecorari, Monica, Carli, Federica, Cuomo, Gianluca, Alfano, Gaetano, Corradi, Luca, Tonelli, Roberto, Maria, Nicola De, Busani, Stefano, Biagioni, Emanuela, Coloretti, Irene, Guaraldi, Giovanni, Sarti, Mario, Luppi, Mario, Clini, Enrico, Girardis, Massimo, Gyssens, Inge C., Mussini, Cristina, Alfano, Gaetano/0000-0003-0591-8622, Tonelli, Roberto/0000-0002-6202-0758, Franceschini, Erica/0000-0001-6922-5759, and Clini, Enrico/0000-0002-1515-5094

Subjects
tocilizumab, QH301-705.5, viruses, SARS-Cov-2, Herpesviridae, Biology (General), steroids, re-activation, Sars-Cov2, Article
Abstract

Background: Herpes simplex 1 co-infections in patients with COVID-19 are considered relatively uncommon, some reports on re-activations in patients in intensive-care units were published. The aim of the study was to analyze herpetic re-activations and their clinical manifestations in hospitalized COVID-19 patients, performing HSV-1 PCR on plasma twice a week. Methods: we conducted a prospective, observational, single-center study involving 70 consecutive patients with severe/critical SARS-CoV-2 pneumonia tested for HSV-1 hospitalized at Azienda Ospedaliero-Universitaria of Modena. Results: of these 70 patients, 21 (30.0%) showed detectable viremia and 13 (62%) had clinically relevant manifestations of HSV-1 infection corresponding to 15 events (4 pneumonia, 5 herpes labialis, 3 gingivostomatitis, one encephalitis and two hepatitis). HSV-1 positive patients were more frequently treated with steroids than HSV-1 negative patients (76.2% vs. 49.0%, p = 0.036) and more often underwent mechanical ventilation (IMV) (57.1% vs. 22.4%, p = 0.005). In the unadjusted logistic regression analysis, steroid treatment, IMV, and higher LDH were significantly associated with an increased risk of HSV1 re-activation (odds ratio 3.33, 4.61, and 16.9, respectively). The association with the use of steroids was even stronger after controlling for previous use of both tocilizumab and IMV (OR = 5.13, 95% CI:1.36–19.32, p = 0.016). The effect size was larger when restricting to participants who were treated with high doses of steroids while there was no evidence to support an association with the use of tocilizumab Conclusions: our study shows a high incidence of HSV-1 re-activation both virologically and clinically in patients with SARS-CoV-2 severe pneumonia, especially in those treated with steroids.

Published
2021

23. The impact of tocilizumab on respiratory support states transition and clinical outcomes in COVID-19 patients. A Markov model multi-state study

Author

Milic, Jovana, primary, Banchelli, Federico, additional, Meschiari, Marianna, additional, Franceschini, Erica, additional, Ciusa, Giacomo, additional, Gozzi, Licia, additional, Volpi, Sara, additional, Faltoni, Matteo, additional, Franceschi, Giacomo, additional, Iadisernia, Vittorio, additional, Yaacoub, Dina, additional, Dolci, Giovanni, additional, Bacca, Erica, additional, Rogati, Carlotta, additional, Tutone, Marco, additional, Burastero, Giulia, additional, Raimondi, Alessandro, additional, Menozzi, Marianna, additional, Cuomo, Gianluca, additional, Corradi, Luca, additional, Orlando, Gabriella, additional, Santoro, Antonella, additional, Digaetano, Margherita, additional, Puzzolante, Cinzia, additional, Carli, Federica, additional, Bedini, Andrea, additional, Busani, Stefano, additional, Girardis, Massimo, additional, Cossarizza, Andrea, additional, Miglio, Rossella, additional, Mussini, Cristina, additional, Guaraldi, Giovanni, additional, and D’Amico, Roberto, additional

Published
2021
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24. Better prognosis in females with severe COVID-19 pneumonia: possible role of inflammation as potential mediator

Author

Mussini, Cristina, primary, Cozzi-Lepri, Alessandro, additional, Menozzi, Marianna, additional, Meschiari, Marianna, additional, Franceschini, Erica, additional, Rogati, Carlotta, additional, Cuomo, Gianluca, additional, Bedini, Andrea, additional, Iadisernia, Vittorio, additional, Volpi, Sara, additional, Milic, Jovana, additional, Tonelli, Roberto, additional, Brugioni, Lucio, additional, Pietrangelo, Antonello, additional, Girardis, Massimo, additional, Cossarizza, Andrea, additional, Clini, Enrico, additional, Guaraldi, Giovanni, additional, Bacca, Erica, additional, Borghi, Vanni, additional, Burastero, Giulia, additional, Carli, Federica, additional, Ciusa, Giacomo, additional, Corradi, Luca, additional, Di Gaetano, Margherita, additional, Faltoni, Matteo, additional, Franceschi, Giacomo, additional, Orlando, Gabriella, additional, Pellegrino, Francesco, additional, Puzzolante, Cinzia, additional, Raimondi, Alessandro, additional, Santoro, Antonella, additional, Tutone, Marco, additional, Yaacoub, Dina, additional, Andreotti, Alberto, additional, Biagioni, Emanuela, additional, Bondi, Filippo, additional, Busani, Stefano, additional, Chierego, Giovanni, additional, Scotti, Marzia, additional, Serio, Lucia, additional, Bellinazzi, Caterina, additional, Borella, Rebecca, additional, De Biasi, Sara, additional, De Gaetano, Anna, additional, Fidanza, Lucia, additional, Gibellini, Lara, additional, Iannone, Anna, additional, Lo Tartaro, Domenico, additional, Mattioli, Marco, additional, Paolini, Annamaria, additional, Fogliani, Rossella, additional, Righini, Grazia, additional, and Lugli, Mario, additional

Published
2021
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25. The Impact of COVID-19 on UNAIDS 90–90–90 Targets: Calls for New HIV Care Models

Author

Guaraldi, Giovanni, primary, Borghi, Vanni, additional, Milic, Jovana, additional, Carli, Federica, additional, Cuomo, Gianluca, additional, Menozzi, Marianna, additional, Santoro, Antonella, additional, Orlando, Gabriella, additional, Puzzolante, Cinzia, additional, Meschiari, Marianna, additional, Franceschini, Erica, additional, Bedini, Andrea, additional, Ferrari, Filippo, additional, Gennari, William, additional, Sarti, Mario, additional, and Mussini, Cristina, additional

Published
2021
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27. Bacterial and Fungal Co-Infections in Patients with COVID-19 Related Pneumonia: A Retrospective Cohort Study

Author

Bedini, Andrea, primary, Menozzi, Marianna, additional, Cuomo, Gianluca, additional, Franceschini, Erica, additional, Orlando, Gabriella, additional, Santoro, Antonella, additional, Cozzi-Lepri, Alessandro, additional, Meschiari, Marianna, additional, Carli, Federica, additional, Puzzolante, Cinzia, additional, Milic, Jovana, additional, Monte, Martina Del, additional, gaetano, Margherita Di, additional, Bacca, Erica, additional, Franceschi, Giacomo, additional, Dolci, Giovanni, additional, Busani, Stefano, additional, Biagioni, Emanuela, additional, Tutone, Marco, additional, Sarti, Mario, additional, Girardis, Massimo, additional, Guaraldi, Giovanni, additional, and Mussini, Cristina, additional

Published
2021
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28. Darunavir/Cobicistat Is Associated with Negative Outcomes in HIV-Negative Patients with Severe COVID-19 Pneumonia

Author

Milic, Jovana, primary, Novella, Alessio, additional, Meschiari, Marianna, additional, Menozzi, Marianna, additional, Santoro, Antonella, additional, Bedini, Andrea, additional, Cuomo, Gianluca, additional, Franceschini, Erica, additional, Digaetano, Margherita, additional, Carli, Federica, additional, Ciusa, Giacomo, additional, Volpi, Sara, additional, Bacca, Erica, additional, Franceschi, Giacomo, additional, Yaacoub, Dina, additional, Rogati, Carlotta, additional, Tutone, Marco, additional, Burastero, Giulia, additional, Faltoni, Matteo, additional, Iadisernia, Vittorio, additional, Dolci, Giovanni, additional, Cossarizza, Andrea, additional, Mussini, Cristina, additional, Pasina, Luca, additional, and Guaraldi, Giovanni, additional

Published
2021
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31. Health status is related to testosterone, estrone and body fat: moving to functional hypogonadism in adult men with HIV

Author

De Vincentis, Sara, primary, Decaroli, Maria Chiara, additional, Fanelli, Flaminia, additional, Diazzi, Chiara, additional, Mezzullo, Marco, additional, Morini, Fabio, additional, Bertani, Davide, additional, Milic, Jovana, additional, Carli, Federica, additional, Cuomo, Gianluca, additional, Santi, Daniele, additional, Tartaro, Giulia, additional, Tagliavini, Simonetta, additional, De Santis, Maria Cristina, additional, Roli, Laura, additional, Trenti, Tommaso, additional, Pagotto, Uberto, additional, Guaraldi, Giovanni, additional, and Rochira, Vincenzo, additional

Published
2021
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32. Incidence, Risk Factors and Mortality Outcome in Patients with Acute Kidney Injury in COVID-19: A Single-Center Observational Study

Author

Fontana Francesco, Paolo R, Gabriella O, Jovana M, Giacomo M, Massimo G, Carli Federica, Cinzia P, Mussini Cristina, Annachiara F, Margherita Dg, Erica F, Gianluca C, Alfano Gaetano, Guaraldi Giovanni, Bedini Andrea, Santoro Antonella, Marianna M, Riccardo M, and Cappelli Gianni

Subjects
Creatinine, medicine.medical_specialty, Proteinuria, urogenital system, Proportional hazards model, business.industry, medicine.medical_treatment, Urinary system, Hazard ratio, Acute kidney injury, Renal function, urologic and male genital diseases, medicine.disease, female genital diseases and pregnancy complications, chemistry.chemical_compound, chemistry, Internal medicine, medicine, Hemodialysis, medicine.symptom, business
Abstract

BackgroundAcute kidney injury (AKI) is a recently recognized complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI in patients with documented COVID-19.MethodsWe reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy.ResultsAKI was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI patients had a mean age of 74.7±9.9 years and higher serum levels of the main marker of inflammation and organ involvement (lung, liver, hearth and liver) than non-AKI patients. AKI events were more frequent in subjects with severe lung comprise. Two peaks of AKI events coincided with in-hospital admission and death of the patients. Kidney injury was associate with a higher rate of urinary abnormalities including proteinuria (0.448±0.85 vs 0.18±0.29; P=ConclusionsAKI was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI and prevention of kidney injury by avoiding dehydration and nephrotoxic agents is imperative in this vulnerable cohort of patients.

Published
2020

34. Machine learning in predicting respiratory failure in patients with COVID-19 pneumonia—Challenges, strengths, and opportunities in a global health emergency

Author

Ferrari, Davide, primary, Milic, Jovana, additional, Tonelli, Roberto, additional, Ghinelli, Francesco, additional, Meschiari, Marianna, additional, Volpi, Sara, additional, Faltoni, Matteo, additional, Franceschi, Giacomo, additional, Iadisernia, Vittorio, additional, Yaacoub, Dina, additional, Ciusa, Giacomo, additional, Bacca, Erica, additional, Rogati, Carlotta, additional, Tutone, Marco, additional, Burastero, Giulia, additional, Raimondi, Alessandro, additional, Menozzi, Marianna, additional, Franceschini, Erica, additional, Cuomo, Gianluca, additional, Corradi, Luca, additional, Orlando, Gabriella, additional, Santoro, Antonella, additional, Digaetano, Margherita, additional, Puzzolante, Cinzia, additional, Carli, Federica, additional, Borghi, Vanni, additional, Bedini, Andrea, additional, Fantini, Riccardo, additional, Tabbì, Luca, additional, Castaniere, Ivana, additional, Busani, Stefano, additional, Clini, Enrico, additional, Girardis, Massimo, additional, Sarti, Mario, additional, Cossarizza, Andrea, additional, Mussini, Cristina, additional, Mandreoli, Federica, additional, Missier, Paolo, additional, and Guaraldi, Giovanni, additional

Published
2020
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35. Changes in central adipose tissue after switching to integrase inhibitors

Author

Debroy, Paula, primary, Feng, Han, additional, Miao, Hongyu, additional, Milic, Jovana, additional, Ligabue, Guido, additional, Draisci, Stefano, additional, Besutti, Giulia, additional, Carli, Federica, additional, Menozzi, Marianna, additional, Mussini, Cristina, additional, Guaraldi, Giovanni, additional, and Lake, Jordan E., additional

Published
2020
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41. COVID-19-associated vasculitis and thrombotic complications: from pathological findings to multidisciplinary discussion

Author

Vacchi, Caterina, primary, Meschiari, Marianna, additional, Milic, Jovana, additional, Marietta, Marco, additional, Tonelli, Roberto, additional, Alfano, Gaetano, additional, Volpi, Sara, additional, Faltoni, Matteo, additional, Franceschi, Giacomo, additional, Ciusa, Giacomo, additional, Bacca, Erica, additional, Tutone, Marco, additional, Raimondi, Alessandro, additional, Menozzi, Marianna, additional, Franceschini, Erica, additional, Cuomo, Gianluca, additional, Orlando, Gabriella, additional, Santoro, Antonella, additional, Di Gaetano, Margherita, additional, Puzzolante, Cinzia, additional, Carli, Federica, additional, Bedini, Andrea, additional, Cossarizza, Andrea, additional, Castaniere, Ivana, additional, Ligabue, Guido, additional, De Ruvo, Nicola, additional, Manco, Gianrocco, additional, Rolando, Giovanni, additional, Gelmini, Roberta, additional, Maiorana, Antonino, additional, Girardis, Massimo, additional, Mascia, Maria Teresa, additional, Mussini, Cristina, additional, Salvarani, Carlo, additional, and Guaraldi, Giovanni, additional

Published
2020
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44. Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV

Author

Guaraldi, Giovanni, primary, Franconi, Iacopo, additional, Milic, Jovana, additional, Besutti, Giulia, additional, Pintassilgo, Ines, additional, Scaglioni, Riccardo, additional, Ligabue, Guido, additional, Riva, Nicoletta, additional, Raimondi, Alessandro, additional, Menozzi, Marianna, additional, Carli, Federica, additional, Zona, Stefano, additional, Santoro, Antonella, additional, Malagoli, Andrea, additional, Borghi, Vanni, additional, Torricelli, Pietro, additional, Cossarizza, Andrea, additional, and Mussini, Cristina, additional

Published
2019
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45. Incidence, risk factors and outcome of acute kidney injury (AKI) in patients with COVID-19.

Author

Alfano, Gaetano, Ferrari, Annachiara, Fontana, Francesco, Mori, Giacomo, Magistroni, Riccardo, Meschiari, Marianna, Franceschini, Erica, Menozzi, Marianna, Cuomo, Gianluca, Orlando, Gabriella, Santoro, Antonella, Digaetano, Margherita, Puzzolante, Cinzia, Carli, Federica, Bedini, Andrea, Milic, Jovana, Coloretti, Irene, Raggi, Paolo, Mussini, Cristina, and Girardis, Massimo

Subjects
ACUTE kidney failure, COVID-19, HEMATURIA, INJURY risk factors, DIAGNOSIS, KIDNEY physiology
Abstract

Background: Acute kidney injury (AKI) is a severe complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate incidence, risk factors and case-fatality rate of AKI in patients with COVID-19. Methods: We reviewed the health medical records of 307 consecutive patients with COVID-19 hospitalized at the University Hospital of Modena, Italy. Results: AKI was diagnosed in 69 out of 307 (22.4%) COVID-19 patients. Stages 1, 2, or 3 AKI accounted for 57.9%, 24.6% and 17.3%, respectively. AKI patients had a mean age of 74.7 ± 9.9 years. These patients showed higher serum levels of the main markers of inflammation and higher rate of severe pneumonia than non-AKI patients. Kidney injury was associated with a higher rate of urinary abnormalities including proteinuria (0.44 ± 0.85 vs 0.18 ± 0.29 mg/mg; P = < 0.0001) and microscopic hematuria (P = 0.032) compared to non-AKI patients. Hemodialysis was performed in 7.2% of the subjects and 33.3% of the survivors did not recover kidney function after AKI. Risk factors for kidney injury were age, male sex, CKD and higher non-renal SOFA score. Patients with AKI had a mortality rate of 56.5%. Adjusted Cox regression analysis revealed that COVID-19-associated AKI was independently associated with in-hospital death (hazard ratio [HR] = 4.82; CI 95%, 1.36–17.08) compared to non-AKI patients. Conclusion: AKI was a common and harmful consequence of COVID-19. It manifested with urinary abnormalities (proteinuria, microscopic hematuria) and conferred an increased risk for death. Given the well-known short-term sequelae of AKI, prevention of kidney injury is imperative in this vulnerable cohort of patients. [ABSTRACT FROM AUTHOR]

Published
2021
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46. One‐year persistence of neutralizing anti‐SARS‐CoV‐2 antibodies in dialysis patients recovered from COVID‐19.

Author

Alfano, Gaetano, Fontana, Francesco, Morisi, Niccolò, Giaroni, Francesco, Mori, Giacomo, Guaraldi, Giovanni, Magistroni, Riccardo, Cappelli, Gianni, Mussini, Cristina, Bacca, Erica, Bedini, Andrea, Borghi, Vanni, Burastero, Giulia, Carli, Federica, Ciusa, Giacomo, Corradi, Luca, Cuomo, Gianluca, Di Gaetano, Margherita, Dolci, Giovanni, and Faltoni, Matteo

Subjects
COVID-19, HEMODIALYSIS patients, SARS-CoV-2, HUMORAL immunity, ANTIBODY titer, HIV seroconversion
Abstract

The immunological mechanisms that modulate immune response to SARS‐CoV‐2 infection remain elusive. Little is known on the magnitude and the durability of antibody response against COVID‐19. There is consensus that patients with immune dysfunction, such as dialysis patients, may be unable to mount a robust and durable humoral immunity after infections. Recent studies showed that dialysis patients seroconverted after COVID‐19, but data on the durability of the immune response are missing. We reported the data of a durable anti‐spike protein seroconversion after natural SARS‐CoV‐2 infection in three patients on hemodialysis with a mean age of 67.2 ± 13.8 years. A mean antibody titer of 212.6 ± 174.9 UA/ml (Liaison®, DiaSorin) was found after one year (range, 366–374 days) from the diagnosis of COVID‐19. In conclusion, this case series provided evidence that patients receiving hemodialysis who recovered from severe COVID‐19 were able to mount a long‐lasting immune response against SARS‐CoV‐2. Although the protective capacity of this long‐term immunity remains to be determined, these patients did not report signs of reinfection after recovery from COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Development of post-COVID-19 cardiovascular events: an analysis of clinical features and risk factors from a single hospital retrospective study.

Author

Cuomo, Gianluca, Puzzolante, Cinzia, Iadisernia, Vittorio, Santoro, Antonella, Menozzi, Marianna, Carli, Federica, Digaetano, Margherita, Orlando, Gabriella, Franceschini, Erica, Bedini, Andrea, Meschiari, Marianna, Manzini, Lisa, Corradi, Luca, Milic, Jovana, Borghi, Vanni, Brugioni, Lucio, Pietrangelo, Antonello, Clini, Enrico, Girardis, Massimo, and Guaraldi, Giovanni

Published
2021
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48. CD4/CD8 ratio is not predictive of multi‐morbidity prevalence in HIV‐infected patients but identify patients with higher CVD risk

Author

Menozzi, Marianna, Zona, Stefano, Santoro, Antonella, Carli, Federica, Stentarelli, Chiara, Mussini, Cristina, and Guaraldi, Giovanni

Subjects
T cells -- Testing, Prognosis -- Evaluation, Cardiovascular diseases -- Physiological aspects, HIV infection -- Development and progression -- Drug therapy, Health
Abstract

Background: CD4/CD8 Materials and Methods: 914 consecutive patients attending Modena Metabolic HIV Clinic were evaluated in a cross‐sectional retrospective study. Inclusion criteria: stable ART from ≥2 years; HIV‐RNA plasma levels=2006). High CVD risk was defined for Framingham Risk Score (FRS)≥6. Subclinical CVD was defined using cardiac CT scan for calcium score (CAC)≥100. Logistic univariate and multivariable adjusted analysis were performed to assess relationships between variables. Results: Demographic and HIV‐specific variables distribution in patients with and without MM are shown in Table 1. Figure 1 shows HANA distribution across CD4/CD8 strata: CVD prevalence only appeared to be higher in patients with no CD4/CD8>0.8.In multivariable analyses CD4/CD8 Conclusions: Low CD4/CD8 ratio was not associated with MM prevalence. Patients with CD4/CD8, Figure 1: HANA distribution across CD4/CD8 strata. [Figure omitted] Table 1: Patients demographic, anthropometric and HIV specific characteristics MM− MM+ P value Total Number 665 (72.5%) 249 (27.5%) – Women [...]

Published
2014
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