Search

Your search keyword '"Carleo, F"' showing total 89 results
Start Over Author "Carleo, F"
89 results on '"Carleo, F"'

1. Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?

Author

Mancuso, M., Pernazza, F., Refai, M., Srella, F., Argnani, D., Marulli, G., De Palma, A., Bortolotti, L., Rizzardi, G., Solli, P.G., Dolci, G.P., Perkmann, R., Zaraca, F., Benvenuti, M., Gavezzoli, D., Cherchi, R., Ferrari, P., Mucilli, F., Camplese, P., Melloni, G., Mazza, F., Cavallesco, G., Maniscalco, P., Voltolini, L., Gonfiotti, A., Sollitto, F., Ardò, N., Pariscenti, G.L., Risso, C., Surrente, C., Lopez, C., Droghetti, A., Giovanardi, M., Breda, C., Giudice, Lo F., Alloisio, M., Bottoni, E., Spaggiari, L., Gasparri, R., Torre, M., Rinaldo, A., Nosotti, M., Tosi, D., Negri, G.P., Bandiera, A., Baisi, A., Raveglia, F., Stefani, A., Natali, P., Scarci, M., Pirondini, E., Curcio, C., Amore, D., Rena, O., Nicotra, S., Dell’ Amore, A., Bertani, A., Tancredi, G., Ampollini, L., Carbognani, P., Puma, F., Vinci, D., Cardillo, G., Carleo, F., Margaritora, S., Meacci, E., Luzzi, L., Ghisalberti, M., Crisci, R., Divisi, D., Lausi, P., Guerrera, F., Fontana, D., Beffa, V. Della, Morelli, A., Londero, F., Imperatori, A., Rotolo, N., Terzi, A., Viti, A., Infante, M., Benato, C., Zaraca, Francesco, Pipitone, Marco, Feil, Birgit, Perkmann, Reinhold, Bertolaccini, Luca, Curcio, Carlo, and Crisci, Roberto

Published
2021
Full Text
View/download PDF

2. Do we really need a chest-CT in Primary Spontaneous Pneumothorax?

Author

Ricciardi, S, primary, Giovanniello, D, additional, Carleo, F, additional, Di Martino, M, additional, Jaus, M O, additional, Mantovani, S, additional, Carbone, L, additional, Aratari, M T, additional, De Massimi, A, additional, Salvadori, L, additional, Treggiari, S, additional, and Cardillo, G, additional

Published
2022
Full Text
View/download PDF

3. EP07.01-017 Malignant Fibrous Solitary Tumour of the Pleura Is Not All the Same: Evaluation of Risk Stratification Models in a Large Single Centre Series

Author

Ricciardi, S., primary, Giovanniello, D., additional, Di Martino, M., additional, Carleo, F., additional, Jaus, M.O., additional, Mantovani, S., additional, Salvadori, L., additional, Aratari, M.T., additional, Carbone, L., additional, De Massimi, A.R., additional, Treggiari, S., additional, and Cardillo, G., additional

Published
2022
Full Text
View/download PDF

5. Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?

Author

Zaraca, Francesco, primary, Pipitone, Marco, additional, Feil, Birgit, additional, Perkmann, Reinhold, additional, Bertolaccini, Luca, additional, Curcio, Carlo, additional, Crisci, Roberto, additional, Mancuso, M., additional, Pernazza, F., additional, Refai, M., additional, Srella, F., additional, Argnani, D., additional, Marulli, G., additional, De Palma, A., additional, Bortolotti, L., additional, Rizzardi, G., additional, Solli, P.G., additional, Dolci, G.P., additional, Perkmann, R., additional, Zaraca, F., additional, Benvenuti, M., additional, Gavezzoli, D., additional, Cherchi, R., additional, Ferrari, P., additional, Mucilli, F., additional, Camplese, P., additional, Melloni, G., additional, Mazza, F., additional, Cavallesco, G., additional, Maniscalco, P., additional, Voltolini, L., additional, Gonfiotti, A., additional, Sollitto, F., additional, Ardò, N., additional, Pariscenti, G.L., additional, Risso, C., additional, Surrente, C., additional, Lopez, C., additional, Droghetti, A., additional, Giovanardi, M., additional, Breda, C., additional, Giudice, Lo F., additional, Alloisio, M., additional, Bottoni, E., additional, Spaggiari, L., additional, Gasparri, R., additional, Torre, M., additional, Rinaldo, A., additional, Nosotti, M., additional, Tosi, D., additional, Negri, G.P., additional, Bandiera, A., additional, Baisi, A., additional, Raveglia, F., additional, Stefani, A., additional, Natali, P., additional, Scarci, M., additional, Pirondini, E., additional, Curcio, C., additional, Amore, D., additional, Rena, O., additional, Nicotra, S., additional, Dell’ Amore, A., additional, Bertani, A., additional, Tancredi, G., additional, Ampollini, L., additional, Carbognani, P., additional, Puma, F., additional, Vinci, D., additional, Cardillo, G., additional, Carleo, F., additional, Margaritora, S., additional, Meacci, E., additional, Luzzi, L., additional, Ghisalberti, M., additional, Crisci, R., additional, Divisi, D., additional, Lausi, P., additional, Guerrera, F., additional, Fontana, D., additional, Beffa, V. Della, additional, Morelli, A., additional, Londero, F., additional, Imperatori, A., additional, Rotolo, N., additional, Terzi, A., additional, Viti, A., additional, Infante, M., additional, and Benato, C., additional

Published
2021
Full Text
View/download PDF

6. Predictors of nodal upstaging in patients with cT1-3N0 non-small cell lung cancer (NSCLC): results from the Italian VATS Group Registry

Author

Marulli, G., Faccioli, E., Mammana, M., Nicotra, S., Comacchio, G., Verderi, E., De Palma, A., Curcio, C., Rea, F., Bertani, A., Russo, E., Voltolini, L., Gonfiotti, A., Nosotti, M., Rosso, L., Muriana, G., Droghetti, A., Crisci, R., Zaccagna, G., Amore, D., di Rienzo, G., Lopez, C., Morelli, A., Londero, F., Spaggiari, L., Gasparri, R., Baietto, G., Casadio, C., Infante, M., Benato, C, Alloisio, M., Bottoni, E, Cardillo, G., Carleo, F., Stella, F., Dolci, G., Puma, F., Vinci, D., Cavallesco, G., Maniscalco, P., Ampollini, L., Carbognani, P., Terzi, A., Viti, A, Negri, G., Bandiera, A., Perkmann, R., Zaraca, F., Andreetti, C., Poggi, C., Mucilli, F., Camplese, P., Luzzi, L., Ghisalberti, M., Imperatori, A., Rotolo, N., Bortolotti, L., Rizzardi, G., Torre, M., Rinaldo, A., Sabbatini, A., Refai, M., Benvenuti, M. R., Benetti, D., Stefani, A., Natali, P., Lausi, P., Guerrera, F., Melloni, G., Mazza, F., Argnani, D., Sanna, S., Fontana, D., Beffa, V. D., Meda, S., Pernazza, F. a, and Italian VATS Group

Subjects
Oncology, Male, Lung Neoplasms, medicine.medical_treatment, non-small cell lung cancer (NSCLC), Nodal upstaging, VATS lobectomy, 0302 clinical medicine, Risk Factors, Carcinoma, Non-Small-Cell Lung, 80 and over, Registries, Non-Small-Cell Lung, Child, Pneumonectomy, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Aged, 80 and over, Thoracic Surgery, Video-Assisted, Thoracic Surgery, General Medicine, Middle Aged, Lymph node dissection, Mediastinal staging, Predictive risk factors, Adolescent, Adult, Aged, Disease Progression, Female, Humans, Italy, Lymph Node Excision, Neoplasm Staging, Predictive Value of Tests, Young Adult, 030220 oncology & carcinogenesis, Predictive value of tests, 030211 gastroenterology & hepatology, Lymph node dissection, Mediastinal staging, Nodal upstaging, Predictive risk factors, VATS lobectomy, medicine.medical_specialty, Video-Assisted, NO, 03 medical and health sciences, Internal medicine, medicine, In patient, business.industry, Disease progression, Carcinoma, medicine.disease, Surgery, Neoplasm staging, business
Abstract

Accurate staging of early non-small cell lung cancer is fundamental for selecting the best treatment. The aim of this study was to identify risk factors for nodal upstaging after video-assisted thoracoscopic lobectomy for clinical T1-3N0 tumors.From 2014 to 2017, 3276 thoracoscopic lobectomies were recorded in the prospective database "Italian VATS Group". Linear and multiple logistic regression models were adapted to identify independent predictors of nodal upstaging and factors associated with progression in postoperative N status.Nodal upstaging was found in 417 cases (12.7%), including 206 cases (6.2%) of N1-positive nodes, 81 cases of N2 nodes (2.4%), and 130 cases (4%) of involvement of both N1 + N2 nodes. A total of 241 (7.3%) patients had single-station nodal involvement, whereas 176 (5.3%) had multiple-station involvement. In the final regression model, the tumor grade, histology, pathologic T status, and 12 resected nodes were independent predictors of nodal upstaging.The number of resected lymph nodes seems to predict nodal upstaging better than the type of intraoperative lymph node management. Other preoperative risk factors correspond to those for which the current guidelines of the European Society of Thoracic Surgery recommend more extensive preoperative mediastinal staging.

Published
2020

7. Correction to: Predictors of nodal upstaging in patients with cT1-3N0 non-small cell lung cancer (NSCLC): results from the Italian VATS Group Registry (Surgery Today, (2020), 50, 7, (711-718), 10.1007/s00595-019-01939-x)

Author

Marulli, G., Faccioli, E., Mammana, M., Nicotra, S., Comacchio, G., Verderi, E., De Palma, A., Curcio, C., Rea, F., Bertani, A., Russo, E., Voltolini, L., Gonfiotti, A., Nosotti, M., Rosso, L., Muriana, G., Droghetti, A., Crisci, R., Zaccagna, G., Amore, D., di Rienzo, G., Lopez, C., Morelli, A., Londero, F., Spaggiari, L., Gasparri, R., Baietto, G., Casadio, C., Infante, M., Benato, C., Alloisio, M., Bottoni, E., Cardillo, G., Carleo, F., Stella, F., Dolci, G., Puma, F., Vinci, D., Cavallesco, G., Maniscalco, P., Ampollini, L., Carbognani, P., Terzi, A., Viti, A., Negri, G., Bandiera, A., Perkmann, R., Zaraca, F., Andreetti, C., Poggi, C., Mucilli, F., Camplese, P., Luzzi, L., Ghisalberti, M., Imperatori, A., Rotolo, N., Bortolotti, L., Rizzardi, G., Torre, M., Rinaldo, A., Sabbatini, A., Refai, M., Benvenuti, M. R., Benetti, D., Stefani, A., Natali, P., Lausi, P., Guerrera, F., Melloni, G., Mazza, F., Argnani, D., Sanna, S., Fontana, D., Beffa, V. D., Meda, S., and Pernazza, F.

Subjects
NO
Published
2020

8. National adoption of video-assisted thoracoscopic surgery (VATS) lobectomy: The Italian VATS register evaluation

Author

Divisi D., Bertolaccini L., Barone M., Amore D., Argnani D., Zaccagna G., Solli P., Di Rienzo G., Curcio C., Crisci R., Ampollini L., Alloisio M., Andreetti C., Baietto G., Bandiera A., Benato C., Benetti D., Benvenuti M., Bertani A., Bortolotti L., Bottoni E., Camplese P., Carbognani P., Cardillo G., Carleo F., Casadio C., Cavallesco G., Negri A. D., Dolci G., Droghetti A., Gasparri R., Ghisalberti M., Gonfiotti A., Guerrera F., Imperatori A., Infante M., Lausi P., Londero F., Lopez C., Luzzi L., Maineri P., Maniscalco P., Marulli G., Monteverde M., Morelli A., Mucilli F., Natali P., Negri G., Nicotra S., Nosotti M., Perkmann R., Poggi C., Puma F., Refai M., Rinaldo A., Rizzardi G., Rosso L., Rotolo N., Russo E., Sabatini A., Spaggiari L., Stefani A., Stella F., Terzi A., Torre M., Vinci D., Viti A., Voltolini L., Zaraca F., Divisi D., Bertolaccini L., Barone M., Amore D., Argnani D., Zaccagna G., Solli P., Di Rienzo G., Curcio C., Crisci R., Ampollini L., Alloisio M., Andreetti C., Baietto G., Bandiera A., Benato C., Benetti D., Benvenuti M., Bertani A., Bortolotti L., Bottoni E., Camplese P., Carbognani P., Cardillo G., Carleo F., Casadio C., Cavallesco G., Negri A.D., Dolci G., Droghetti A., Gasparri R., Ghisalberti M., Gonfiotti A., Guerrera F., Imperatori A., Infante M., Lausi P., Londero F., Lopez C., Luzzi L., Maineri P., Maniscalco P., Marulli G., Monteverde M., Morelli A., Mucilli F., Natali P., Negri G., Nicotra S., Nosotti M., Perkmann R., Poggi C., Puma F., Refai M., Rinaldo A., Rizzardi G., Rosso L., Rotolo N., Russo E., Sabatini A., Spaggiari L., Stefani A., Stella F., Terzi A., Torre M., Vinci D., Viti A., Voltolini L., Zaraca F., Divisi, Duilio, Bertolaccini, Luca, Barone, Mirko, Amore, Dario, Argnani, Desideria, Zaccagna, Gino, Solli, Piergiorgio, Di Rienzo, Gaetano, Curcio, Carlo, Crisci, Roberto, Italian VATS, Group, and Negri, G

Subjects
Database, Learning curve, Learning tools, Non-small cell lung cancer, Training, Video-assisted thoracoscopic surgery lobectomy (VATS lobectomy), Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, VATS lobectomy, Air leak, NO, 03 medical and health sciences, 0302 clinical medicine, Learning tool, database, learning curve, learning tools, non-small cell lung cancer, training, medicine, Thoracotomy, business.industry, General surgery, Database, Learning curve, Learning tools, Non-small cell lung cancer, Training, Video-assisted thoracoscopic surgery lobectomy (VATS lobectomy), 030228 respiratory system, Cardiothoracic surgery, 030220 oncology & carcinogenesis, Video-assisted thoracoscopic surgery, Operative time, Original Article, business
Abstract

Background: The expertise curve of video-assisted thoracoscopic surgery (VATS) lobectomies still stirs debate and controversy both because of the number of procedures to carry out and of the evaluation of the learning threshold. The purpose of our study was the examination of the variables related to the learning curve of the video-assisted approach, to establish what may be an expression of the technical maturity of the surgeon. Methods: The National Register for VATS lobectomy built in 2013 was used to collect data from 65 Thoracic Surgery Units. Out of more than 3,700 patients enrolled, only information from Units with ≥100 VATS lobectomies were retrospectively analysed. Unpaired Student’s t-tests, Fisher’s exact tests, Pearson’s χ 2 were applied as needed. Cumulative summative analysis and one-way ANOVA were used to identify the expertise curve of VATS lobectomy. Results: Ten institutions contributed a total of 1,679 patients, who were divided into three uniform groups according to the chronological sequence of surgery. The length of utility incision, the number of dissected lymph nodes and the operative time were not statistically significant (P=0.999, P=0.972 and P=0.307, respectively) among groups. Conversion to thoracotomy and postoperative air leaks occurred in 125 (7.44%) and 109 (6.49%) patients, gradually declined in Group 3 with statistical signi cance (P=0.048 and P=0.00086). Conclusions: The conversion rate and the percentage of air leaks seem to de ne the expertise of VATS lobectomy, being linked to the ability to manage more complicated surgical cases or intraoperative adverse events.

Published
2018

10. First italian consensus conference on VATS lobectomy for NSCLC

Author

Nosotti, Mario, Droghetti, Andrea, Luzzi, Luca, Solli, Piergiorgio, Crisci, Roberto, VATS Group Italia, Alloisio, M, Amore, D, Ampollini, D, Andreetti, C, Aresu, Argnani, D, Baletto, G, Bandiera, A, Benato, C, Bertani, A, Bertolaccini, L, Bortolotti, L, Camplese, P, Carbognani, P, Cardillo, G, Carleo, F, Cavallesco, G, Curcio, C, Dell’Amore, D, De Monte, L, Denegri, A, De Vico, A, Di Rienzo, G, Divisi, D, Dolci, Gp, Ghisalberti, M, Giovanardi, M, Gonfiotti, A, Gotti, G, Imperatori, A, Infante, M, Lo faso, F, Lopez, C, Magnanelli, G, Maineri, P, Mancuso, M, Maniscalco, P, Marulli, G, Morelli, A, Mucilli, F, Muriana, G, Negri, Gp, Nicotra, S, Palleschi, A, Perkmann, R, Pernazza, F, Poggi, C, Puma, F, Rinaldo, A, Rizzardi, G, Roncon, A, Rosso, L, Rotolo, N, Solaini, L, Stella, F, Terzi, A, Torre, M, Vinci, D, Voltolini, L, and Zaraca, F

Subjects
medicine.medical_specialty, Surgical strategy, medicine, consensus conference, medicine.medical_treatment, VATS lobectomy, practical recommendations, thoracotomy, 030204 cardiovascular system & hematology, carcinoma, lung neoplasms, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Medicine, Thoracotomy, lung cancer, non-small-cell lung, humans, Italy, thoracic surgery, video-assisted, oncology, cancer research, video-assisted, Perioperative management, business.industry, Thoracic Surgery, Video-Assisted, General surgery, Consensus conference, General Medicine, thoracic surgery, 030228 respiratory system, Cardiothoracic surgery, business
Abstract

Purpose Video-assisted thoracoscopic surgery (VATS) lobectomy has become an accepted procedure for the treatment of selected cases of lung cancer. The aim of this project was to establish national practical recommendations for the management of patients suitable for VATS lobectomy. Methods The Scientific Committee of the VATS Lobectomy Group (a branch of the Italian Society of Thoracic Surgery) identified the consensus conference as an appropriate tool for a national debate. The consensus conference was organized following indications of the Italian Department of Health: a panel of experts reviewed the literature, the jury board revised the experts’ reports, and the national conference discussed and voted on statements. The strength of recommendation for a statement was classified as weak, fair, or high when the total score ranged between 51% and 67%, 68% and 84%, or 85% and 100%, respectively. Results Eighty-six Italian thoracic surgeons attended the 1st Italian Consensus Conference on VATS lobectomy in Giulianova, Italy, on October 29-30, 2015. Thirty-three topics were discussed: indications, surgical strategy, perioperative management, and training were the main topics. Consensus was reached on 24 statements that were consequently recommended. Conclusions The Italian Consensus Conference is the first attempt to discuss VATS lobectomy-related issues in a national scientific community. Such experience determined an improvement in epistemic knowledge among the Italian thoracic surgeons and could be a suggestion for other national communities.

Published
2017

22. Risk factors and impact of conversion from VATS to open lobectomy: analysis from a national database

Author

Bongiolatti, Stefano, Gonfiotti, Alessandro, Viggiano, Domenico, Borgianni, Sara, Politi, Leonardo, Crisci, Roberto, Curcio, Carlo, Voltolini, Luca, Italian Vats Group, Carlo, Curcio, Dario, Amore, Giuseppe, Marulli, Samuele, Nicotra, Andrea De Negri, Paola, Maineri, Gaetano Di Rienzo, Camillo, Lopez, Roberto, Crisci, Duilio, Divisi, Angelo, Morelli, Alessandro, Bertani, Francesco, Londero, Lorenzo, Rosso, Lorenzo, Spaggiari, Roberto, Gasparri, Guido, Baietto, Caterina, Casadio, Maurizio, Infante, Cristiano, Benato, Marco, Alloisio, Edoardo, Bottoni, Andrea, Droghetti, Andrea, Giovanardi, Giuseppe, Cardillo, Francesco, Carleo, Luca, Bertolaccini, Piergiorgio, Solli, Franco, Stella, Giampiero, Dolci, Francesco, Puma, Damiano, Vinci, Giorgio Cavallesco Pio Maniscalco, Desideria, Argnani, Luca, Ampollini, Paolo, Carbognani, Alberto, Terzi, Andrea, Viti, Giampiero, Negri, Alessandro, Bandiera, Reinhold, Perkmann, Francesco, Zaraca, Ibrahim, Mohsen, Poggi, Camilla, Felice, Mucilli, Pierpaolo, Camplese, Luca, Luzzi, Marco, Ghisalberti, Andrea, Imperatori, Nicola, Rotolo, Luigi, Bortolotti, Giovanna, Rizzardi, Massimo, Torre, Alessandro, Rinaldo, Armando, Sabbatini, Majed, Refai, Mauro Roberto Benvenuti, Diego, Benetti, Alessandro, Stefani, Pamela, Natali, Paolo, Lausi, Francesco, Guerrera, Bongiolatti S., Gonfiotti A., Viggiano D., Borgianni S., Politi L., Crisci R., Curcio C., Voltolini L., Amore D., Marulli G., Nicotra S., De Negri A., Maineri P., DiRienzo G., Lopez C., Divisi D., Morelli A., Bertani A., Russo E., Londero F., Rosso L., Spaggiari L., Gasparri R., Baietto G., Casadio C., Infante M., Benato C., Alloisio M., Bottoni E., Droghetti A., Giovanardi A., Cardillo G., Carleo F., Bertolaccini L., Solli P., Stella F., Dolci G., Puma F., Vinci D., Cavallesco G., Maniscalco P., Argnani D., Ampollini L., Carbognani P., Terzi A., Viti A., Negri G., Bandiera A., Perkmann R., Zaraca F., Ibrahim M., Poggi C., Mucilli F., Camplese P., Luzzi L., Ghisalberti M., Imperatori A., Rotolo N., Bortolotti L., Rizzardi G., Torre M., Rinaldo A., Sabbatini A., Refai M., Benvenuti M.R., Benetti D., Stefani A., Natali P., Lausi P., Guerrera F., Bongiolatti, S., Gonfiotti, A., Viggiano, D., Borgianni, S., Politi, L., Crisci, R., Curcio, C., Voltolini, L., Amore, D., Marulli, G., Nicotra, S., De Negri, A., Maineri, P., Dirienzo, G., Lopez, C., Divisi, D., Morelli, A., Bertani, A., Russo, E., Londero, F., Rosso, L., Spaggiari, L., Gasparri, R., Baietto, G., Casadio, C., Infante, M., Benato, C., Alloisio, M., Bottoni, E., Droghetti, A., Giovanardi, A., Cardillo, G., Carleo, F., Bertolaccini, L., Solli, P., Stella, F., Dolci, G., Puma, F., Vinci, D., Cavallesco, G., Maniscalco, P., Argnani, D., Ampollini, L., Carbognani, P., Terzi, A., Viti, A., Negri, G., Bandiera, A., Perkmann, R., Zaraca, F., Ibrahim, M., Poggi, C., Mucilli, F., Camplese, P., Luzzi, L., Ghisalberti, M., Imperatori, A., Rotolo, N., Bortolotti, L., Rizzardi, G., Torre, M., Rinaldo, A., Sabbatini, A., Refai, M., Benvenuti, M. R., Benetti, D., Stefani, A., Natali, P., Lausi, P., and Guerrera, F.

Subjects
Male, Lung Neoplasms, Complications, Databases, Factual, medicine.medical_treatment, Sex Factor, Conversion, Lobectomy, Lung cancer, Video-assisted thoracic surgery, 0302 clinical medicine, Risk Factors, Retrospective Studie, Carcinoma, Non-Small-Cell Lung, Age Factor, Thoracotomy, Non-Small-Cell Lung, Pneumonectomy, Thoracic Surgery, Video-Assisted, Mortality rate, Age Factors, Thoracic Surgery, Middle Aged, Conversion to Open Surgery, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, VATS lobectomy, Video-Assisted, NO, Databases, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, Humans, Factual, Retrospective Studies, Aged, Complications, Conversion, Lobectomy, Lung cancer, Video-assisted thoracic surgery, business.industry, Risk Factor, Carcinoma, Lymphatic Metastasi, Retrospective cohort study, Video-assisted thoracic surgery · Lobectomy · Lung cancer · Conversion · Complications, Lung Neoplasm, Chest tube, Surgery, Complication, business, Abdominal surgery
Abstract

Objective: The objective of the study is to analyse the causes and impact of conversion from VATS to thoracotomy identifying any possible pre-operative risk factors and related consequences. Methods: Data from patient who underwent VATS lobectomy (VATS-L) for NSCLC at VATS Group participating centres were retrospectively analysed and divided in two groups: patients treated with VATS-L and patients who suffered from conversion. Predictors of conversion were assessed with univariate and multivariable exact logistic regression. Complications were evaluated as dependent variables of conversion in a Cox multivariable logistic regression model. Results: A total of 4629 patients underwent planned VATS-L for NSCLC and of these, 432 (9.3%) required conversion; the most frequent causes were bleeding (30.4%) and fibro-calcified hilar lymph nodes (23.9%). The independent risk factors at multivariable analysis model were sex male (OR 1.458, p < 0.01), age older than 70years (OR 1.248, p = 0.036) and the clinically node-positive disease (OR 2.258, p < 0.01). The mortality rate was similar, but the percentage of patients who suffered from any complication (41.7% vs 24.4%, p < 0.01), the complication rate (65% vs 32.2%, p < 0.01), chest tube duration (p < 0.01) and the hospitalisation rate (p < 0.01) were higher for patients converted. Atrial fibrillation (OR 1.471, p = 0.019), prolonged air leak (OR 1.403, p = 0.043), blood transfusions (OR 4.820, p < 0.01), sputum retention (OR 1.80, p = 0.027) and acute kidney failure (OR 2.758, p = 0.03) were significantly associated with conversion at multivariable analysis. Conclusions: Conversion is associated with increased surgical morbidity, blood loss and hospital stay. Sex male, old age and the clinical involvement of lymph nodes were the strongest predictors of conversion.

Published
2019

23. Residenza, domicilio e dimora

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

24. Nascita ed esistenza

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

25. Nozione di matrimonio e sistema matrimoniale italiano

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

26. Modi acquisto della proprietà a titolo originario

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

27. La giurisdizione ecclesiastica e gli accertamenti del giudice statale in materia di matrimonio concordatario

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

28. Capacità giuridica. Soggettività. Personalità

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

29. Riservatezza e banche dati

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

30. Diritto all'oblio

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

31. Diritti della personalità ed enti collettivi

Author

PERLINGIERI, CAROLINA, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, Perlingieri, Carolina, and Pietro Perlingieri

Subjects
diritti, persona, enti, enti non riconosciuti
Abstract

diritti della personalità ed enti non riconosciuti

Published
2021

32. Incapacità d'intendere o di volere

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

33. Minore età: dalla potestà dei genitori alla responsabilità genitoriale

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

34. Diritto alla riservatezza

Author

Carolina Perlingieri, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, P. Perlingieri, and Perlingieri, Carolina

Published
2021

35. Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry

Author

Luca Bertolaccini, Fabio Davoli, Alessandro Pardolesi, Jury Brandolini, Desideria Argnani, Alessandro Bertani, Andrea Droghetti, Alessandro Gonfiotti, Duilio Divisi, Roberto Crisci, Piergiorgio Solli, Mario Nosotti, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano di Rienzo, Camillo Lopez, Angelo Morelli, Francesco Londero, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Giuseppe Cardillo, Francesco Carleo, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco, Pio Maniscalco, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Reinhold Perkmann, Francesco Zaraca, Claudio Andretti, Camilla Poggi, Felice Mucilli, Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre, Alessandro Rinaldo, Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera, Bertolaccini, Luca, Davoli, Fabio, Pardolesi, Alessandro, Brandolini, Jury, Argnani, Desideria, Bertani, Alessandro, Droghetti, Andrea, Gonfiotti, Alessandro, Divisi, Duilio, Crisci, Roberto, Solli, Piergiorgio, Nosotti, Mario, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco, Bertolaccini L., Davoli F., Pardolesi A., Brandolini J., Argnani D., Bertani A., Droghetti A., Gonfiotti A., Divisi D., Crisci R., Solli P., Nosotti M., Curcio C., Amore D., Marulli G., Nicotra S., De Negri A., Maineri P., di Rienzo G., Lopez C., Morelli A., Londero F., Spaggiari L., Gasparri R., Baietto G., Casadio C., Infante M., Benato C., Alloisio M., Bottoni E., Cardillo G., Carleo F., Stella F., Dolci G., Puma F., Vinci D., Cavallesco G., Maniscalco P., Ampollini L., Carbognani P., Terzi A., Viti A., Negri G., Bandiera A., Perkmann R., Zaraca F., Andretti C., Poggi C., Mucilli F., Camplese P., Luzzi L., Ghisalberti M., Imperatori A., Rotolo N., Bortolotti L., Rizzardi G., Torre M., Rinaldo A., Sabbatini A., Refai M., Benvenuti M.R., Benetti D., Stefani A., Natali P., Lausi P., and Guerrera F.

Subjects
Registrie, Male, Complications, Lung Neoplasms, medicine.medical_treatment, Iatrogenic Disease, 030204 cardiovascular system & hematology, 0302 clinical medicine, Retrospective Studie, Risk Factors, Thoracotomy, Registries, Pneumonectomy, Video-assisted thoracic surgery lobectomy, Univariate analysis, Thoracic Surgery, Video-Assisted, Thoracic Surgery, General Medicine, Treatment Outcome, Oncology, Italy, Cardiothoracic surgery, Female, Lung cancer, Human, medicine.medical_specialty, Complications, Conversion, Lung cancer, Lymph nodes dissection, Vascular injury, Video-assisted thoracic surgery lobectomy, VATS lobectomy, Video-Assisted, Vascular injury, NO, 03 medical and health sciences, medicine, Conversion, Lymph nodes dissection, Aged, Humans, Retrospective Studies, Vascular System Injuries, business.industry, Risk Factor, nutritional and metabolic diseases, Retrospective cohort study, medicine.disease, Surgery, Lung Neoplasm, 030228 respiratory system, business, Complication
Abstract

Objectives Vascular injuries are among the most severe causes of unplanned conversion during VATS lobectomies. The study aimed to analyse the incidence of vascular injuries and their risk factors during VATS lobectomy. Methods The Italian VATS lobectomy Registry was used to collect data from 66 Thoracic Surgery Units. From 2013 to October 2016 (out of more than 3,700 patients enrolled) only information from Units with an enrollment >100 VATS lobectomies were retrospectively analysed. Logistic regression analysis was performed on selected variables of the univariate analysis. Results Ten institutions contributed a total of 1,679 patients. Vascular injuries leading to conversion occurred in 44 (2.6%) patients. Years of experiences were inversely related to the risk of vascular injuries. Univariate analysis showed age, gender, surgical activity, Charlson Index Score and number of resected lymph nodes like significantly associated variables. Multivariate analysis revealed that number of resected lymph nodes, VATS experience ratio (number of VATS lobectomies/total lobectomies performed in the same year at same centre), and surgical activity of the centre were significantly associated with the risk of conversion. Unplanned thoracotomy was correlated with postoperative morbidity. Conclusion Vascular injuries in VATS lobectomies represented a rare complication which could directly affect the postoperative outcomes. The predictive factors for conversion were multifactorial and depended on characteristics of centres and surgeons’ seniority. Minimally invasive VATS lobectomy approaches did not influence the risk of vascular damages.

Published
2019

37. Smoking cessation intervention within the framework of a lung cancer screening program: preliminary results and clinical perspectives from the 'Cosmos-II' Trial

Author

Francesco Carleo, Giovanni Apolone, Giulia Veronesi, Alfredo Cesario, Giuseppe Cardillo, Lococo Filippo, Rosastella Principe, Pasquale Ialongo, Lococo, F, Principe, R, Cesario, A, Apolone, G, Carleo, F, Ialongo, P, Veronesi, G, and Cardillo, G.

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, Lung Neoplasms, Time Factors, medicine.medical_treatment, Rome, Smoking Prevention, Recurrence, Risk Factors, Internal medicine, medicine, Humans, Lung cancer, Early Detection of Cancer, Aged, Retrospective Studies, Motivation, business.industry, Smoking, Smoking cessation intervention, Middle Aged, medicine.disease, Physical therapy, Smoking cessation, Patient Compliance, Female, Smoking Cessation, business, Lung cancer screening, Program Evaluation
Abstract

Data coming from the literature investigating the effectiveness and interaction between smoking cessation (SC) and lung cancer screening (LCScr) are still sparse and inconsistent. Herein, we report the preliminary results from the ongoing lung cancer screening trial (“Cosmos-II”) focusing our analysis on the inter-relationship between the SC program and the LCScr.

Published
2014

38. Documento informatico, firme elettroniche e atto pubblico informatico

Author

Carolina Perlingieri, Pietro Perlingieri, Perlingieri, Carolina, A. Alpini, V. Barba, G. Biscontini, E. Briganti, E. Capobianco, G. Carapezza Figlia G. Chiappetta, N. Cipriani, O. Clarizia, L. Corsaro, M.V. Cozzi, C. Crea F. Criscuolo, P. D’Addino, M. D’Ambrosio, P. D’Amico, A. Di Amato, S. Di Amato R. Di Raimo, V. Donato, C. Donisi, R. Favale, A. Federico, P. Femia, L. Ferroni A. Flamini, M. Galli, M. Imbrenda, F. Lazzarelli, G. Lisella, O. Lombardi L. Lonardo, F. Maisto, A. Malomo, D. Mantucci, G. Marinaro, E. Migliaccio E. Minervini, R. Mongillo, F. Nappi, A.C. Nazzaro, R. Pane, M. Pennasilico C. Perlingieri, G. Perlingieri, S. Polidori, I. Prisco, F. Prosperi, G. Recinto, V. Rizzo G. Romano, L. Rossi Carleo, F. Ruscello, T.V. Russo, F. Sbordone, P. Stanzione A. Tartaglia Polcini, G. Tatarano, B. Troisi, L. Tullio, M.A. Urciuoli D. Valentino, F. Volpe, G. Zarra, and P. Perlingieri

Abstract

Documento informatico e firme elettroniche Valore probatorio. problematica dell'atto pubblico informatico.

Published
2014

39. Prognostic factors in a multicentre study of 247 atypical pulmonary carcinoids

Author

Niccolò Daddi, Marco Schiavon, Pier Luigi Filosso, Giuseppe Cardillo, Marcello Carlo Ambrogi, Angela De Palma, Luca Luzzi, Alessandro Bandiera, Christian Casali, Alberto Ruffato, Verena De Angelis, Luigi Gaetano Andriolo, Francesco Guerrera, Francesco Carleo, Federico Davini, Moira Urbani, Sandro Mattioli, Uliano Morandi, Piero Zannini, Giuseppe Gotti, Michele Loizzi, Francesco Puma, Alfredo Mussi, Alberto Ricci, Alberto Oliaro, Federico Rea, on behalf of the Multi-Institutional Italian Pathology Group, Rosanna Capozzi, Valentina Tassi, Vincenzo Pagliarulo, Marco Ghisalberti, Fiorella Calabrese, Anna Sapino, Luisa Delsedime, Paolo Graziano, Greta Alì, Gabriella Fontanini, Angelo Sidoni, Stefano Ascani, Xenia Trabucco, Donatella Sina, Gianluigi Arrigoni, Giulio Rossi, Claudio Agostinelli, Niccolò Daddi, Marco Schiavon, Pier Luigi Filosso, Giuseppe Cardillo, Marcello Carlo Ambrogi, Angela De Palma, Luca Luzzi, Alessandro Bandiera, Christian Casali, Alberto Ruffato, Verena De Angeli, Luigi Gaetano Andriolo, Francesco Guerrera, Francesco Carleo, Federico Davini, Moira Urbani, Sandro Mattioli, Uliano Morandi, Piero Zannini, Giuseppe Gotti, Michele Loizzi, Francesco Puma, Alfredo Mussi, Alberto Ricci, Alberto Oliaro, Federico Rea, on behalf of the Multi-Institutional Italian Pathology Group, Rosanna Capozzi, Valentina Tassi, Vincenzo Pagliarulo, Marco Ghisalberti, Fiorella Calabrese, Anna Sapino, Luisa Delsedime, Paolo Graziano, Greta Alì, Gabriella Fontanini, Angelo Sidoni, Stefano Ascani, Xenia Trabucco, Donatella Sina, Gianluigi Arrigoni, Giulio Rossi, Claudio Agostinelli, Daddi, N, Schiavon, M, Filosso, Pl, Cardillo, G, Ambrogi, Mc, DE PALMA, A, Luzzi, L, Bandiera, A, Casali, C, Ruffato, A, DE ANGELIS, V, Andriolo, Lg, Guerrera, F, Carleo, F, Davini, F, Urbani, M, Mattioli, S, Morandi, U, Zannini, Piero, Gotu, G, Loizzi, M, Puma, F, Mussi, A, Ricci, A, Oliaro, A, Rea, F, and the Multi Institutional Italian Pathology, Group

Subjects
Male, Lung Neoplasms, Pathological staging, medicine.medical_treatment, Kaplan-Meier Estimate, Pulmonary Surgical Procedures, Gastroenterology, Tumourlets, RADIATION THERAPY, 80 and over, Medicine, Child, Adjuvant therapy, Atypical carcinoids, Chemotherapy, Multicentric forms, Surgery, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Lymph Node Excision, Middle Aged, Prognosis, Retrospective Studies, Young Adult, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Medicine (all), Univariate analysis, Hazard ratio, General Medicine, Atypical carcinoid, Tumourlet, medicine.medical_specialty, Pneumonectomy, Internal medicine, Lung cancer, business.industry, Proportional hazards model, Multicentric form, LUNG CANCER, medicine.disease, Lymphadenectomy, business
Abstract

OBJECTIVES: To analyse clinical and biomolecular prognostic factors associated with the surgical approach and the outcome of 247 patients affected by primary atypical carcinoids (ACs) of the lung in a multi-institutional experience. METHODS: We retrospectively evaluated clinical data and pathological tissue samples collected from 247 patients of 10 Thoracic Surgery Units from different geographical areas of our country. All patients were divided into four groups according to surgical procedure: sub-lobar resections (SURG1), lobar resections (SURG2), tracheobronchoplastic procedures (SURG3) and pneumonectomies (SURG4). Overall survival analysis was performed using the Kaplan-Meier method and log-rank test. Survival was calculated from the date of surgery to the last date of follow-up or death. The parameters evaluated included age, gender, smoking habits, laterality, type of surgery, 7th edition of TNM staging, mitosis Ki-67 (MIB1), multifocal forms, tumourlets, type of lymphadenectomy and neo/adjuvant therapy. For multivariate analysis, a Cox regression model was used with a forward stepwise selection of covariates. RESULTS: Two hundred and forty-seven patients (124 females and 123 males; range 10-84, median 60 years) underwent surgical resection for AC in the last 30 years as follows: n = 38 patients in SURG1, 181 in SURG2, 15 in SURG3 and 14 in SURG4. A smoking history was present in 136 of 247 (55%) patients. The median follow-up period was 98.7 (range 11.2-369.9) months. The overall survival probability analysis of the AC was 86.7% at 5 years, 72.4% at 10 years, 64.4% at 15 years and 58.1% at 20 years. Neuroendocrine multicentric forms were detected in 12 of 247 patients (4.8%; 1 of 12 pts) during the follow-up (range 11.2-200.4, median 98.7 months) and 33.4% had recurrence of disease. There were no significant differences between gender, tumour location and type of surgery at the multivariate analysis. Age [P < 0.001, hazard ratio (HR) 0.60; confidence interval (CI) 0.32-1.12], smoking habits (P = 0.002; HR 0.43, 95% CI 0.23-0.80) and lymph nodal metastatic involvement (P = 0.008; HR 0.46, 95% CI 0.26-0.82) were all significant at multivariate analysis. CONCLUSIONS: ACs of the lung are malignant neuroendocrine tumours with a worst outcome in patients over 70 years and in smokers. With the exception of pneumonectomy, the extent of resection does not seem to affect survival and should be accompanied preferably by lymphadenectomy. Pathological staging, along with a mitotic index more than Ki-67 (MIB1), appears to be the most significant prognostic factor at the univariate analysis.

Published
2013

40. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy.

Author

Parini S, Azzolina D, Massera F, Mastromarino MG, Papalia E, Baietto G, Curcio C, Crisci R, Rena O, Alloisio M, Amore D, Ampollini L, Ardò N, Argnani D, Baisi A, Bandiera A, Benato C, Benvenuti MR, Bertani A, Bortolotti L, Bottoni E, Breda C, Camplese P, Carbognani P, Cardillo G, Carleo F, Cavallesco G, Cherchi R, De Palma A, Dell'Amore A, Della Beffa V, Divisi D, Dolci G, Droghetti A, Ferrari P, Fontana D, Gasparri R, Gavezzoli D, Ghisalberti M, Giovanardi M, Gonfiotti A, Guerrera F, Imperatori A, Infante M, Lausi P, Lo Giudice F, Londero F, Lopez C, Mancuso M, Maniscalco P, Margaritora S, Marulli G, Mazza F, Meacci E, Melloni G, Morelli A, Mucilli F, Natali P, Negri G, Nicotra S, Nosotti M, Paladini P, Pariscenti G, Perkmann R, Pernazza F, Pirondini E, Puma F, Raveglia F, Refai M, Rinaldo A, Risso C, Rizzardi G, Rotolo N, Scarci M, Solli P, Sollitto F, Spaggiari L, Stefani A, Stella F, Surrente C, Tancredi G, Terzi A, Torre M, Tosi D, Vinci D, Viti A, Voltolini L, and Zaraca F

Subjects
Humans, Body Mass Index, Pneumonectomy adverse effects, Thoracic Surgery, Video-Assisted adverse effects, Treatment Outcome, Obesity complications, Postoperative Complications etiology, Retrospective Studies, Overweight complications, Thinness complications
Abstract

The aim of this study was to assess the impact of BMI on perioperative outcomes in patients undergoing VATS lobectomy or segmentectomy. Data from 5088 patients undergoing VATS lobectomy or segmentectomy, included in the VATS Group Italian Registry, were collected. BMI (kg/m 2 ) was categorized according to the WHO classes: underweight, normal, overweight, obese. The effects of BMI on outcomes (complications, 30-days mortality, DFS and OS) were evaluated with a linear regression model, and with a logistic regression model for binary endpoints. In overweight and obese patients, operative time increased with BMI value. Operating room time increased by 5.54 minutes (S.E. = 1.57) in overweight patients, and 33.12 minutes (S.E. = 10.26) in obese patients (P < 0.001). Compared to the other BMI classes, overweight patients were at the lowest risk of pulmonary, acute cardiac, surgical, major, and overall postoperative complications. In the overweight range, a BMI increase from 25 to 29.9 did not significantly affect the length of stay, nor the risk of any complications, except for renal complications (OR: 1.55; 95% CI: 1.07-2.24; P = 0.03), and it reduced the risk of prolonged air leak (OR: 0.8; 95% CI: 0.71-0.90; P < 0.001). 30-days mortality is higher in the underweight group compared to the others. We did not find any significant difference in DFS and OS. According to our results, obesity increases operating room time for VATS major lung resection. Overweight patients are at the lowest risk of pulmonary, acute cardiac, surgical, major, and overall postoperative complications following VATS resections. The risk of most postoperative complications progressively increases as the BMI deviates from the point at the lowest risk, towards both extremes of BMI values. Thirty days mortality is higher in the underweight group, with no differences in DFS and OS., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Published
2023
Full Text
View/download PDF

41. Malignant Solitary Fibrous Tumours of the Pleura Are Not All the Same: Analysis of Long-Term Outcomes and Evaluation of Risk Stratification Models in a Large Single-Centre Series.

Author

Ricciardi S, Giovanniello D, Carbone L, Carleo F, Di Martino M, Jaus MO, Mantovani S, Treggiari S, Tornese A, and Cardillo G

Abstract

Introduction: Malignant solitary fibrous tumours of the pleura (mSFTP) are extremely rare diseases (<5% of all pleural neoplasms) with unpredictable behaviour. Surgery remains the standard of care for these tumours; however, estimating patient prognosis and planning follow-up remain challenging. Several risk stratification models have been proposed, but a classification with diagnostic and prognostic potential has not been well standardised yet. The aim of this study was to analyse the clinicopathological data of mSFTP to investigate their prognostic features and to compare the performance of three risk stratification models proposed in the literature. Methods: Observational retrospective cohort study on all proven cases of mSFTP surgically resected with radical intent between 2000 and 2019 in a single centre. Demographic, surgical and pathological data were examined. All patients were risk-stratified by using three prediction models: modified Demicco, De Perrot and Tapias. Overall survival (OS) and disease-free survival (DFS) were analysed. Results: There were 21 men and 13 women (median age, 67 years, range, 23-83 years). Twenty-one patients (62%) were symptomatic. The median follow-up was 111 months (range, 6-258 months). The 5-year OS and DFS were 81.2% and 77.4%, respectively. Nine patients (26.5%) experimented recurrences. At univariate analysis, the presence of necrosis ( p = 0.019), nuclear atypia ( p = 0.006), dimension greater than 11.5 cm (median value of our cohort) ( p = 0.037) and relapse/disease progression ( p = 0.001) were independent prognostic factor of worse OS. The administration of adjuvant treatment was a protective independent factor for survival ( p = 0.001). Radicality of resection ( p = 0.005); tumour dimension ( p = 0.013), presence of necrosis ( p = 0.041) and nuclear atypia ( p = 0.007) and pleural pattern ( p = 0.011) were independent prognostic factors of worse DFS. Analysing the three risk stratification models, the Tapias score was revealed as the best index to predict both OS ( p = 0.002) and DFS ( p = 0.047) in patients with mSFTP. Conclusions: Using the risk stratification model proposed by Tapias, patients with the highest risk of recurrence could be identified at the time of surgery to establish a more frequent imaging surveillance and longer follow-up. The role of adjuvant treatment in mSFTP therapy has not been established yet, but further analysis on patients with a high risk of recurrence, stratified according to risk models, along with biomolecular panels may tailor future post-surgical therapies.

Published
2023
Full Text
View/download PDF

42. Which Surgery for Stage II-III Empyema Patients? Observational Single-Center Cohort Study of 719 Consecutive Patients.

Author

Ricciardi S, Giovanniello D, Carleo F, Di Martino M, Jaus MO, Mantovani S, Treggiari S, Tritapepe L, and Cardillo G

Abstract

Objective: Recent guidelines support the use of thoracoscopic surgery in stage II-III empyema; however, there is still debate regarding the best surgical approach. The aim of our study is to compare postoperative outcomes of VATS and open surgical approaches for the treatment of post-pneumonic empyema., Methods: Observational cohort study on prospectively collected cases of post-pneumonic empyema surgically treated in a single center (2000-2020). Patients were divided into an open group (OT, posterolateral muscle sparing thoracotomy) and VATS group (VT, 2 or 3 port ± utility incision). The primary outcome of the study was empyema resolution, assessed by the recurrence rate. Secondary outcomes were mortality, complications, pain and return to daily life. All patients were followed up at 1, 3 and 6 months after surgery in the outpatient clinic with a chest radiograph/CT scan., Results: In total, 719 consecutive patients were surgically treated for stage II-III empyema, with 644 belonging to the VT group and 75 to the OT group. All patients had a clinical history of pneumonia lasting no more than 6 months before surgery, and 553 (76.9%) had stage II empyema. Operative time was 92.7 ± 6.8 min for the OT group and 112.2 ± 7.4 for the VT group. The conversion rate was 8.4% (46/545) for stage II and 19.2% (19/99) for stage III. Twelve patients (1.86%) in the VT group and four patients (5.3%) in the OT group underwent additional surgery for bleeding. Postoperative mortality was 1.25% (9/719): 5.3% (4/75) in OT and 0.77% (5/644) in VT. Postoperative stay was 10 ± 6.5 days in OT and 8 ± 2.4 in VT. Overall morbidity was 14.7% (106/719): 21.3% (16/75) in OT and 13.9% (90/644) in VT. In VT, six patients (0.93%) showed recurrent empyema: five were treated with chest drainage and one with additional open surgery., Conclusions: Our findings suggest that the VATS approach, showing a 99% success rate, shorter length of stay and lower postoperative morbidity, should be considered the treatment of choice for thoracic empyema.

Published
2022
Full Text
View/download PDF

43. Post-intubation tracheal lacerations: Risk-stratification and treatment protocol according to morphological classification.

Author

Cardillo G, Ricciardi S, Forcione AR, Carbone L, Carleo F, Di Martino M, Jaus MO, Perdichizzi S, Scarci M, Ricci A, Dello Iacono R, Lucantoni G, and Galluccio G

Abstract

Background: Post-intubation tracheal laceration (PITL) is a rare condition (0.005% of intubations). The treatment of choice has traditionally been surgical repair. Following our first report in 2010 of treatment protocol tailored to a risk-stratified morphological classification there is now clear evidence that conservative therapy represents the gold standard in the majority of patients. In this paper we aim to validate our risk-stratified treatment protocol through the largest ever reported series of patients., Methods: This retrospective analysis is based on a prospectively collected series (2003-2020) of 62 patients with PITL, staged and treated according to our revised morphological classification., Results: Fifty-five patients with Level I (#8), II (#36) and IIIA (#11) PITL were successfully treated conservatively. Six patients with Level IIIB injury and 1 patient with Level IV underwent a surgical repair of the trachea. No mortality was reported. Bronchoscopy confirmed complete healing in all patients by day 30. Statistical analysis showed age only to be a risk factor for PITL severity., Conclusions: Our previously proposed risk-stratified morphological classification has been validated as the major tool for defining the type of treatment in PITL., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2022 Cardillo, Ricciardi, Forcione, Carbone, Carleo, Di Martino, Jaus, Perdichizzi, Scarci, Ricci, Dello Iacono, Lucantoni and Galluccio.)

Published
2022
Full Text
View/download PDF

44. Malignant Pleural Mesothelioma Nodal Status: Where Are We at?

Author

Ricciardi S, Carleo F, Jaus MO, Di Martino M, Carbone L, Ricci A, and Cardillo G

Abstract

Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remains highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in determining treatment strategy. Notwithstanding the improvement in pre-treatment staging and the update on lymph node classification in the 8th edition of TNM, several open controversies remain on N parameter. How should we stage suspected N+ patients? How should we treat node positive patients? Which is the definition of a "resectable patient"? Is the site or the number the main prognostic factor for node positive patients? The aim of our narrative review is to analyse the existing relevant literature on lymph node status in MPM.

Published
2021
Full Text
View/download PDF

45. Application of Artificial Neural Network to Preoperative 18 F-FDG PET/CT for Predicting Pathological Nodal Involvement in Non-small-cell Lung Cancer Patients.

Author

Taralli S, Scolozzi V, Boldrini L, Lenkowicz J, Pelliccioni A, Lorusso M, Attieh O, Ricciardi S, Carleo F, Cardillo G, and Calcagni ML

Abstract

Purpose: To evaluate the performance of artificial neural networks (aNN) applied to preoperative 18 F-FDG PET/CT for predicting nodal involvement in non-small-cell lung cancer (NSCLC) patients. Methods: We retrospectively analyzed data from 540 clinically resectable NSCLC patients (333 M; 67.4 ± 9 years) undergone preoperative 18 F-FDG PET/CT and pulmonary resection with hilo-mediastinal lymphadenectomy. A 3-layers NN model was applied (dataset randomly splitted into 2/3 training and 1/3 testing). Using histopathological reference standard, NN performance for nodal involvement (N0/N+ patient) was calculated by ROC analysis in terms of: area under the curve (AUC), accuracy (ACC), sensitivity (SE), specificity (SP), positive and negative predictive values (PPV, NPV). Diagnostic performance of PET visual analysis (N+ patient: at least one node with uptake ≥ mediastinal blood-pool) and of logistic regression (LR) was evaluated. Results: Histology proved 108/540 (20%) nodal-metastatic patients. Among all collected data, relevant features selected as input parameters were: patients' age, tumor parameters (size, PET visual and semiquantitative features, histotype, grading), PET visual nodal result (patient-based, as N0/N+ and N0/N1/N2). Training and testing NN performance (AUC = 0.849, 0.769): ACC = 80 and 77%; SE = 72 and 58%; SP = 81 and 81%; PPV = 50 and 44%; NPV = 92 and 89%, respectively. Visual PET performance: ACC = 82%, SE = 32%, SP = 94%; PPV = 57%, NPV = 85%. Training and testing LR performance (AUC = 0.795, 0.763): ACC = 75 and 77%; SE = 68 and 55%; SP = 77 and 82%; PPV = 43 and 43%; NPV = 90 and 88%, respectively. Conclusions: aNN application to preoperative 18 F-FDG PET/CT provides overall good performance for predicting nodal involvement in NSCLC patients candidate to surgery, especially for ruling out nodal metastases, being NPV the best diagnostic result; a high NPV was also reached by PET qualitative assessment. Moreover, in such population with low a priori nodal involvement probability, aNN better identify the relatively few and unexpected nodal-metastatic patients than PET analysis, so supporting the additional aNN use in case of PET-negative images., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Taralli, Scolozzi, Boldrini, Lenkowicz, Pelliccioni, Lorusso, Attieh, Ricciardi, Carleo, Cardillo and Calcagni.)

Published
2021
Full Text
View/download PDF

46. Is 18F-fluorodeoxyglucose positron emission tomography/computed tomography useful to discriminate metachronous lung cancer from metastasis in patients with oncological history?

Author

Taralli S, Scolozzi V, Triumbari EK, Carleo F, Di Martino M, De Massimi AR, Ricciardi S, Cardillo G, and Calcagni ML

Subjects
Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Fluorodeoxyglucose F18, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology, Positron Emission Tomography Computed Tomography
Abstract

Background: Solitary pulmonary nodules detected during follow-up in patients with previous cancer history have a high probability of malignancy being either a metachronous lung cancer or a metastasis. This distinction represents a crucial issue in the perspective of "personalized medicine," implying different treatments and prognosis. Aim, to evaluate the role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in distinguishing whether solitary pulmonary nodules are metachronous cancers or metastases and the relationship between the nodule's characteristics and their nature., Methods: From a single-institution database, we retrospectively selected all patients with a previous cancer history who performed 18F-FDG PET/CT to evaluate pulmonary nodules detected during follow-up, ranging from 5 mm to 40 mm, and histologically diagnosed as malignant., Results: Between September 2009 and August 2017, 127 patients (80 males; mean age=70.2±8.5years) with 127 malignant nodules were included: 103/127 (81%) metachronous cancers, 24/127 (19%) metastases. In both groups, PET/CT provided good and equivalent detection rate of malignancy (81% vs. 83%). No differences between metachronous cancers and metastases were found in: patient's age (70.3±8.1 years vs. 69.5±9.7years), gender (males=63.1% vs. 62.5%), interval between previous cancer diagnosis and nodules' detection (median time=4years vs. 4.5years), location (right-lung=55% vs. 54%; upper-lobes=64% vs. 67%; central-site=31% vs. 25%), size (median size=17mm vs. 19.5mm), 18F-FDG standardized uptake value (median SUVmax=5.2 vs. 5.9)., Conclusions: In oncological patients, despite its high detection rate, 18F-FDG PET/CT, as well as any other clinico-anatomical features, cannot distinguish whether a malignant solitary pulmonary nodule is a metachronous lung cancer or a metastasis, supporting the need of histological differential diagnosis.

Published
2020
Full Text
View/download PDF

47. 3D Reconstruction Model of an Extra-Abdominal Desmoid Tumor: A Case Study.

Author

Marinozzi F, Carleo F, Novelli S, Di Martino M, Cardillo G, Petrella L, and Bini F

Abstract

In recent years, three-dimensional reconstruction (3DR) models have become a standard tool in several medical fields such as education, surgical training simulation, patient-doctor communication, and surgical planning. Postoncologic reconstructive surgery in thoracic diseases might benefit from 3DR models; however, limited data on this application have been published worldwide. In this paper, the aim was to report our experience with 3DR modeling to determine resection and plan the surgical reconstruction in a patient with a desmoid tumor of the chest wall. For a better understanding of the case study, we describe all the steps from acquiring computed tomography (CT) scans to the final 3D rendering. A 68-year-old, non-smoking man presented at our outpatient department with painless swelling of the right anterobasal chest wall. A thorax-abdomen-brain CT scan revealed homogenous solid tissue with a dense mass measuring 80 mm × 62 mm. The final 3D model was evaluated by the surgical team (three medical doctors), who found the model to be powerful. Based on the results and the accuracy of the model, the multidisciplinary team decided that the tumor was resectable. Consequently, a surgical plan based on the 3D model was developed to perform chest wall reconstruction after radical resection. The patient underwent right anterolateral thoracotomy at the seventh intercostal space, which confirmed the CT scan findings and revealed infiltration of the serratus muscle and medial portion of the diaphragm. A radical tumor en bloc resection with chest wall and diaphragm resection was performed. The full-thickness chest wall and diaphragm defects were reconstructed using two separate biological patches of a porcine dermal collagen implant (Permacol™ Surgical Implant). Postoperative X-ray revealed unremarkable findings; the patient had an uneventful recovery and was discharged 6 days after surgery. This case study illustrates that 3DR models enable a personalized approach to the treatment of desmoid tumors. Therefore, this approach should be developed further and studied systematically., (Copyright © 2020 Marinozzi, Carleo, Novelli, Di Martino, Cardillo, Petrella and Bini.)

Published
2020
Full Text
View/download PDF

48. Modeling the Full Time-Dependent Phenomenology of Filled Rubber for Use in Anti-Vibration Design.

Author

Carleo F, Plagge J, Whear R, Busfield J, and Klüppel M

Abstract

Component design of rubber-based anti-vibration devices remains a challenge, since there is a lack of predictive models in the typical regimes encountered by anti-vibration devices that are deformed to medium dynamic strains (0.5 to 3.5) at medium strain rates (0.5/s to 10/s). An approach is proposed that demonstrates all non-linear viscoelastic effects such as hysteresis and cyclic stress softening. As it is based on a free-energy, it is fast and easily implementable. The fitting parameters behave meaningfully when changing the filler volume fraction. The model was implemented for use in the commercial finite element software ABAQUS. Examples of how to fit experimental data and simulations for a variety of carbon black filled natural rubber compounds are presented.

Published
2020
Full Text
View/download PDF

49. Is Adjuvant Chemotherapy Worthwhile After Radical Resection for Single Lung Metastasis From Colorectal Cancer? A Multicentric Analysis Evaluating the Risk of Recurrence.

Author

Rapicetta C, Lococo F, Davini F, Carleo F, Kauppi J, Di Stefano TS, Ricciardi S, Di Martino M, Räsänen J, Paci M, Melfi F, and Cardillo G

Abstract

Background: Adjuvant chemotherapy after resection of colorectal cancer (CRC) lung metastases may reduce recurrences and improve survival. The choice of best candidates for adjuvant chemotherapy in this setting is controversial, especially when a single lung metastases (SLM) is resected. The aim of this study is to evaluate the risk of recurrence after radical resection for single lung metastasis from CRC. Patients and methods: Demographic, clinical, and pathological data were retrospectively collected for patients radically operated on for single pulmonary metastasis from CRC in 4 centers. Survival was computed by Kaplan-Meyer methods. Chi-square, log-rank test, and for multivariate analysis, Cox-regression and binary logistic regression were used when indicated. Results: The sample consisted of 344 patients, mean age 65 yrs. Overall 5 yrs survival was 61.9%. Recurrence occurred in 113 pts (32.8%). At univariate analysis, age > 70 ( p = 0.046) and tumor size > 2 cm ( p = 0.038) were predictive of the worst survival chance, while synchronous lung metastasis ( p = 0.039), previous resection of extrathoracic metastasis ( p = 0.017), uptake at FDG-PET scan ( p = 0.006) and short (<12 months) disease-free interval (DFI) prior to lung metastasectomy ( p = 0.048) were risk factors for recurrence. At multivariate analysis, only high CEA (>4 ng/mL) was associated with worst survival (HR: 4.3, p = 0.014), while prior abdominal surgery (HR: 3, p = 0.033), PET positivity (HR: 2.7, p = 0.041), and DFI > 12 months (HR: 0.14, p < 0.001) confirmed to predict recurrence of disease. Conclusions: Surgical resection of solitary lung metastases from CRC is associated with prolonged survival. High value of CEA, PET positivity, previous extrathoracic resected metastasis, and short (<12 months) DFI were found to be predictive of death or disease recurrence and might identify in this scenario patients at higher risk which could potential benefit of chemotherapy.

Published
2019
Full Text
View/download PDF

50. Limitations of Viscoelastic Constitutive Models for Carbon-Black Reinforced Rubber in Medium Dynamic Strains and Medium Strain Rates.

Author

Carleo F, Barbieri E, Whear R, and Busfield JJC

Abstract

Modelling the viscoelastic behavior of rubber for use in component design remains a challenge. Most of the literature does not consider the typical regimes encountered by anti-vibration devices that are deformed to medium dynamic strains (0.5 to 3.5) at medium strain rates (0.5/s to 10/s). Previous studies have either focused on the behaviour at small strains and small strain rates or in fast loading conditions that result in low cycle fatigue or tearing phenomena. There is a lack of understanding of the dynamic response of natural rubber suspension components when used in real vehicle applications. This paper presents a review of popular viscoelastic nonlinear constitutive models and their ability to model the mechanical behaviour of typical elastomer materials such as Natural Rubber (NR) incorporating different PHR (Parts per Hundred Rubber, XX) of carbon black. The range of strain and strain rate are typical for the materials used in rubber suspensions when operating in severe service operating conditions, such as over rough terrain or over pot-holes. The cyclic strain is applied at different amplitudes and different strain rates in this medium strain range. Despite the availability of many models in the literature, our study reports that none of the existing models can fit the data satisfactorily over a wide range of conditions.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results