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1. Contents Vol. 92, 2002

Author

Sun Woo Lim, Choung Soo Kim, Bertalan Fodor, Yukihiko Kawasaki, Hirofumi Matuoka, Tadao Oohara, Shozo Hosokawa, Y. Asano, Su-Kil Park, Izzet Yavuz, Yasuhide Nakashima, K. Tamba, E. Kusano, Jung Ho Cha, A. Concheiro Guisan, Seval Izdes, Giuseppe Rizzuto, Kaori Kanegae, Yasuo Imanishi, Sumiko Homma, Chul Woo Yang, Sadayoshi Ito, A. Sturiale, Müjdat Yenicesu, Toshiaki Makino, Cheri V. Barrett, Toshihiko Miwa, Yasuro Kumeda, Chin-Huang Chen, Nora Klenk, Chun-Cheng Hou, Hitoshi Suzuki, J. Charles Jennette, Cüneyt Ensari, Shoji Nogae, Won Seok Yang, Ju Young Jung, Ken Farrington, Massimino Senatore, Hitoshi Goto, Tülin Gümüş, Mükerrem Safali, Yi-Hong Chou, Yoshiyuki Tomiyoshi, Ottó Árkossy, Ronald J. Falk, Jorge Isaac, Gilbert Deray, Ruriko Nozawa, Gloria A. Preston, N. Frisina, Abdülgaffar Vural, Junzo Suzuki, Shigeru Nakai, Masaaki Inaba, Toshikatsu Shimizu, J.A. Camacho Diaz, Magdolna Aleksza, Wei-Ming Hsu, Akihiko Osajima, Magali Ciroldi, Petra Marchand, Erzsébet Ladányi, Hirofumi Anai, Sacit Turanli, Hyung Wook Kim, T. Rengarajan, Patrizia Colombo, M. Suzuki, Y. Watanabe, Wu-Chang Yang, Yasuhiro Akai, Masahito Tamura, F. Corica, Eri Muso, Koichiro Homma, L. Garcia Garcia, Jürgen Floege, Xixin Wu, Motoaki Miyazono, A. Gimenez Llort, Laurence Fardet, Motoshi Hattori, F. Floccari, Aquiles Jara, Yoshihiko Saito, Eveline Sowa, Zeki Odabaşi, Yoko Fujino, Song Lin, Vincent Launay-Vacher, Júlia Széll, Lee-Moi Thien, Silvia Pierangeli, Koji Harada, Jaime Pereira, Akane Kurisu, Nai-Phon Wang, Tomoko Nakamura, R. Ravichandran, Susumu Makino, Mária Takács, Marcela Vasquez, Masahiro Okazaki, Yuri Ozawa, Yong Soo Kim, G. Di Pasquale, Chiew H. Kong, A. Ruello, Hassane Izzedine, Takeshi Suda, Luigia Costantini, Itsuro Kazama, Tsen-Tsai Chen, A. Favaloro, A. Romeo, M. Sommer, Ryuichiro Konda, Hiroshi Shiraga, Hideo Nakai, Soon Bae Kim, J. Gerth, Michele Buemi, G. Anastasi, Oliviero Filiberti, Sándor Sipka, Tatsuya Nakatani, Takahiko Nagahama, Keiji Fujiwara, Kyoko Kitauchi, Masayuki Iwano, Narutoshi Kabashima, Satoru Kawaguchi, Takanobu Sakemi, Yasushi Asano, Carla Peona, Akira Owada, Satish M. Rao, Sigeyuki Takeda, Naoko Matsumoto, Jung Sik Park, Tsung-Hsiu Wang, Michiko Suzuki, Hidehiro Kakizaki, Masao Kanauchi, Aranka Koós, Iván Palomo, Yasuhiro Komatsu, Mari Michimata, Pasqualina Cecere, Kayser Caglar, Y. Oyama, Sang Koo Lee, Giovanna Piccini, Lin Shan, Deniz Ayli, O. Iimura, M. Buemi, Mitsunobu Matsubara, Takao Saruta, J. Vila Cots, Yee-Yung Ng, Katsuya Nonomura, Toru Shinzato, Eiji Kusano, Masako Iwamoto, G. Stein, Shigehisa Aoki, Masuhisa Nakamura, Takeshi Kanda, G. Cutroneo, U. Eismann, Qiu Mingcai, Toshio Hashimoto, Ulf Janssen, Masamiki Miwa, Susan L. Hogan, Takayuki Ota, Kosei Segawa, A. Vila Santandreu, Mayumi Nagata, Yutaka Imai, Omac Tufekcioglu, Yoshiyuki Matsuo, Heinfried H. Radeke, David A. Alcorta, An S. De Vriese, Takahiko Ono, Paik-Seong Lim, Gisho Honda, Arnold J. Felsenfeld, Katsumi Ito, Chang-Linct Yang, M. Imai, Yutaro Hayashi, Koichi Hayashi, Bum Soon Choi, C. Aloisi, Enikő Sárváry, Cecilia Chacón, Wan Young Kim, Marcelo Alarcón, Tsutomu Araki, Byung Kee Bang, Jin Kim, Huaji Chen, Shigeo Suzuki, Gabriella Lakos, Attila Nagy, Yoshiki Nishizawa, C. Ito, Can Li, Fuad S. Shihab, Yuujiro Watanabe, A O Phillips, Toshihiko Hata, Kenji Maeda, Lesley C Dinwiddie, Eiji Ishimura, Shin Suda, Antonio Nicoletti, Chui-Mei Tiu, Norio Kurumatani, Seung Hun Lee, and Ning Liu

Subjects
Traditional medicine, business.industry, Medicine, business
Published
2002

2. Immune Dysfunction and Cytokine Production in Hemodialysis

Author

Oliviero Filiberti, Giovanna Piccini, Carla Peona, Michele Buemi, Pasqualina Cecere, Massimino Senatore, Antonio Nicoletti, Giuseppe Rizzuto, Patrizia Colombo, and Luigia Costantini

Subjects
biology, business.industry, medicine.medical_treatment, Immune system, Cytokine, Antigen, Immunology, Humoral immunity, biology.protein, medicine, Macrophage, Cytotoxic T cell, Antibody, business, Antigen-presenting cell
Abstract

Most uremic patients in dialysis therapy develop an immunodeficiency characterized clinically by frequent infectious complications and impaired response to vaccinations [1]. This became evident in the early period of hemodialysis treatment when endemic outbreaks of hepatitis B threatened dialysis centers [2]. Vaccination results against hepatitis B, in dialysis patients, are disappointing: low results are also documented for most other types of vaccinations in these patients, such as influenza [3], tetanus [4] or diphteria [5]. There is an only exception in using vaccination containing polysaccharide antigens like pneumococcus [6]. Polysaccharide antigens are recognized by B cells on their own, but for recognition of other antigens, B cells need specific T-cell help: these observations indicate that the major defects appear to be in cellmediated immunity [7–9] and in particular correlated to T-cell rather than B-cell function [10]. In normal conditions, in response to antigens, naive CD4+ T cells differentiate into effector T helper (Th) cells. Based on their pattern of cytokine production and their functional responses, Th cells can be subdivided into those that participate in cell-mediated immune responses such as delayed type of hypersensitivity reactions and macrophage activation (Th1 subset) and those releasing cytokines that induce B cells to secrete antibodies (Th2 subset). Several factors are known to polarize the differentiation of Th cells into either Th1 or Th2 direction, including the co-stimulatory action of antigen presenting cells (APCs), the cytokine environment, altered peptide ligands and the antigen dose. In particular, Th1 are characterized by elevated secretion of interleukin (IL)-2, transforming growth factor-s (TGF-s) and interferon-A (IFN-A), thereby activating cytotoxic T lymphocytes and macrophages. Moreover, IFN-A suppresses Th2 which induces humoral immunity. The Th2 subset of CD4+ T cells preferentially secretes IL-4, IL-5, IL-6 and IL-10 [11– 13], stimulating the proliferation of mast cells and eosinophils as well as the production of immunoglobulins and IL-10 which may suppress the Th1-induced cell-mediated immunity [14, 15]. In general, Th1 cytokines promote Th1 and inhibit Th2 activities and vice versa. Th1 and Th2 responses should, therefore, be stable [16]. Chronic renal failure induces a clinical state of immunodeficiency in most patients: immune defects may be caused by uraemic state itself and by a direct consequence of dialytic therapy [17, 18]. Dialysis has been associated with acute changes in the complement activation status, granulocyte markers, macrophage function, T-cell activation and the release of various pro-inflammatory cytokines. Although the physiolog

Published
2002

3. Subject Index Vol. 92, 2002

Author

Satoru Kawaguchi, Takanobu Sakemi, Ken Farrington, Itsuro Kazama, Yukihiko Kawasaki, Hidehiro Kakizaki, Masao Kanauchi, Toshihiko Hata, Y. Oyama, Sang Koo Lee, Mitsunobu Matsubara, Hiroshi Shiraga, T. Rengarajan, Patrizia Colombo, Kenji Maeda, Takao Saruta, Masaaki Inaba, Eiji Kusano, Oliviero Filiberti, Erzsébet Ladányi, Shigehisa Aoki, Sumiko Homma, Sadayoshi Ito, Abdülgaffar Vural, Hitoshi Suzuki, Hyung Wook Kim, Yasuhiro Akai, F. Corica, Takahiko Ono, Koji Harada, Giovanna Piccini, Yoshiyuki Tomiyoshi, Gilbert Deray, Sun Woo Lim, Sándor Sipka, Sigeyuki Takeda, Masayuki Iwano, Takeshi Kanda, Aquiles Jara, Júlia Széll, Arnold J. Felsenfeld, Cecilia Chacón, Zeki Odabaşi, Yoko Fujino, Yasuro Kumeda, Nora Klenk, Chin-Huang Chen, Lesley C Dinwiddie, Qiu Mingcai, Satish M. Rao, Iván Palomo, Hitoshi Goto, Choung Soo Kim, Akane Kurisu, Pasqualina Cecere, Eiji Ishimura, Hirofumi Anai, Bertalan Fodor, Jorge Isaac, Yong Soo Kim, Paik-Seong Lim, Gisho Honda, Tatsuya Nakatani, Toru Shinzato, Antonio Nicoletti, M. Imai, Masuhisa Nakamura, Mükerrem Safali, Byung Kee Bang, Fuad S. Shihab, U. Eismann, Michiko Suzuki, Yuujiro Watanabe, Toshikatsu Shimizu, Luigia Costantini, Lin Shan, Deniz Ayli, M. Buemi, Shigeo Suzuki, J. Vila Cots, Gabriella Lakos, Vincent Launay-Vacher, Carla Peona, Akira Owada, Aranka Koós, Yoshihiko Saito, Yasuhide Nakashima, Jin Kim, Huaji Chen, Akihiko Osajima, Petra Marchand, Mari Michimata, Masako Iwamoto, Yee-Yung Ng, Toshio Hashimoto, J. Gerth, G. Anastasi, Chui-Mei Tiu, R. Ravichandran, G. Cutroneo, J.A. Camacho Diaz, Magdolna Aleksza, Song Lin, Susan L. Hogan, A O Phillips, Kayser Caglar, Eri Muso, Shin Suda, Koichiro Homma, Y. Watanabe, Wu-Chang Yang, Katsuya Nonomura, Attila Nagy, Cheri V. Barrett, Sacit Turanli, Susumu Makino, Norio Kurumatani, Yoshiki Nishizawa, Yutaka Imai, Seung Hun Lee, Ning Liu, Takahiko Nagahama, Ulf Janssen, F. Floccari, Lee-Moi Thien, Nai-Phon Wang, Jürgen Floege, Chiew H. Kong, G. Stein, A. Romeo, Xixin Wu, Ryuichiro Konda, Izzet Yavuz, Soon Bae Kim, Müjdat Yenicesu, Masahiro Okazaki, Y. Asano, Su-Kil Park, C. Aloisi, Takayuki Ota, Mayumi Nagata, Giuseppe Rizzuto, Wan Young Kim, Masamiki Miwa, Yuri Ozawa, Mária Takács, Chang-Linct Yang, A. Ruello, Kaori Kanegae, Yasuo Imanishi, Marcela Vasquez, Kyoko Kitauchi, A. Sturiale, Motoaki Miyazono, Toshiaki Makino, Gloria A. Preston, David A. Alcorta, Yasushi Asano, Hideo Nakai, Kosei Segawa, Yutaro Hayashi, A. Vila Santandreu, A. Gimenez Llort, Laurence Fardet, G. Di Pasquale, Yoshiyuki Matsuo, Takeshi Suda, Naoko Matsumoto, Masahito Tamura, Jung Sik Park, K. Tamba, Koichi Hayashi, E. Kusano, Omac Tufekcioglu, Chun-Cheng Hou, Toshihiko Miwa, J. Charles Jennette, Cüneyt Ensari, Yasuhiro Komatsu, Shoji Nogae, Won Seok Yang, Ju Young Jung, A. Favaloro, Jung Ho Cha, Enikő Sárváry, Ottó Árkossy, Ronald J. Falk, C. Ito, Junzo Suzuki, Marcelo Alarcón, Can Li, O. Iimura, Motoshi Hattori, Keiji Fujiwara, Chul Woo Yang, Silvia Pierangeli, Jaime Pereira, Tsutomu Araki, Shigeru Nakai, L. Garcia Garcia, Heinfried H. Radeke, An S. De Vriese, M. Sommer, Michele Buemi, Katsumi Ito, Massimino Senatore, Narutoshi Kabashima, Bum Soon Choi, Tülin Gümüş, Yi-Hong Chou, Ruriko Nozawa, N. Frisina, Wei-Ming Hsu, Magali Ciroldi, Hirofumi Matuoka, Tadao Oohara, Shozo Hosokawa, A. Concheiro Guisan, Seval Izdes, M. Suzuki, Eveline Sowa, Hassane Izzedine, Tsen-Tsai Chen, Tomoko Nakamura, and Tsung-Hsiu Wang

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
2002

4. Association between platelet annexin-V binding and the occurrence of arteriovenous fistula thrombosis in haemodialyzed patients

Author

Alberto Santagostino, Carmelo Libetta, Carla Peona, Vincenzo Sepe, Natalia Rossi, and Antonio Dal Canton

Subjects
Blood Platelets, Risk, Pathology, medicine.medical_specialty, Time Factors, Sensitivity and Specificity, Annexin, Renal Dialysis, medicine, Humans, Platelet, Annexin A5, Enzyme Inhibitors, business.industry, Arteriovenous fistula thrombosis, Vascular biology, Thrombosis, Hematology, medicine.disease, Flow Cytometry, ROC Curve, Arteriovenous Fistula, business, Dialysis, Protein Binding
Abstract

Association between platelet annexin-V binding and the occurrence of arteriovenous fistula thrombosis in haemodialyzed patients

Published
2004

6. Acknowledgement to the Reviewers

Author

Yasuro Kumeda, Nora Klenk, Itsuro Kazama, Shin Suda, Ryuichiro Konda, Soon Bae Kim, Satish M. Rao, Iván Palomo, Toru Shinzato, Ken Farrington, Masayuki Iwano, Yukihiko Kawasaki, A. Sturiale, Ronald J. Falk, Yoshiyuki Tomiyoshi, Gilbert Deray, U. Eismann, Masaaki Inaba, Silvia Pierangeli, Marcela Vasquez, L. Garcia Garcia, Yasuhide Nakashima, Hitoshi Suzuki, Aquiles Jara, Júlia Széll, G. Di Pasquale, Takeshi Suda, Jaime Pereira, Lin Shan, Deniz Ayli, M. Buemi, Yee-Yung Ng, Masahito Tamura, Akane Kurisu, Satoru Kawaguchi, Takanobu Sakemi, Hidehiro Kakizaki, Masao Kanauchi, Y. Oyama, J. Vila Cots, A. Favaloro, Ulf Janssen, Kosei Segawa, Yoshiyuki Matsuo, Mükerrem Safali, Susumu Makino, Massimino Senatore, Tülin Gümüş, Yi-Hong Chou, Yong Soo Kim, G. Stein, J.A. Camacho Diaz, Magdolna Aleksza, A. Romeo, Masako Iwamoto, Ruriko Nozawa, Akihiko Osajima, Y. Asano, Keiji Fujiwara, G. Cutroneo, T. Rengarajan, Patrizia Colombo, Su-Kil Park, Hiroshi Shiraga, Oliviero Filiberti, Eri Muso, Koichiro Homma, Jürgen Floege, Sigeyuki Takeda, Takahiko Ono, Arnold J. Felsenfeld, Takayuki Ota, A. Vila Santandreu, N. Frisina, Wei-Ming Hsu, Magali Ciroldi, Choung Soo Kim, Bertalan Fodor, Mari Michimata, Lee-Moi Thien, Nai-Phon Wang, Masahiro Okazaki, Yuri Ozawa, Petra Marchand, J. Charles Jennette, Motoshi Hattori, Xixin Wu, Chin-Huang Chen, Izzet Yavuz, Pasqualina Cecere, A. Ruello, Omac Tufekcioglu, Heinfried H. Radeke, Cheri V. Barrett, Kyoko Kitauchi, Jin Kim, Zeki Odabaşi, Yoko Fujino, Hitoshi Goto, Huaji Chen, Hideo Nakai, M. Imai, An S. De Vriese, Hirofumi Matuoka, Seung Hun Lee, Ning Liu, Attila Nagy, Yoshiki Nishizawa, Carla Peona, Akira Owada, Aranka Koós, Katsumi Ito, Tadao Oohara, Shozo Hosokawa, M. Suzuki, Bum Soon Choi, Aled O. Phillips, Yasuhiro Komatsu, Kayser Caglar, M. Sommer, Sun Woo Lim, Michele Buemi, Tsung-Hsiu Wang, Giovanna Piccini, Toshihiko Hata, Luigia Costantini, Tomoko Nakamura, Y. Watanabe, Wu-Chang Yang, Katsuya Nonomura, Masuhisa Nakamura, Narutoshi Kabashima, Kenji Maeda, J. Gerth, Toshihiko Miwa, Sang Koo Lee, Eveline Sowa, Masamiki Miwa, G. Anastasi, Mitsunobu Matsubara, Takao Saruta, A. Concheiro Guisan, Seval Izdes, Susan L. Hogan, Shigehisa Aoki, Antonio Nicoletti, Lesley C Dinwiddie, Fuad S. Shihab, Paik-Seong Lim, Eiji Kusano, Gisho Honda, Takahiko Nagahama, Yuujiro Watanabe, Yutaka Imai, Enikő Sárváry, Yasushi Asano, Eiji Ishimura, Yoshihiko Saito, Mayumi Nagata, Takeshi Kanda, Toshio Hashimoto, F. Floccari, Qiu Mingcai, Naoko Matsumoto, Michiko Suzuki, C. Aloisi, Wan Young Kim, Chui-Mei Tiu, Cecilia Chacón, David A. Alcorta, Jung Sik Park, Hassane Izzedine, Mária Takács, Tsen-Tsai Chen, Byung Kee Bang, Koichi Hayashi, Junzo Suzuki, Motoaki Miyazono, A. Gimenez Llort, Giuseppe Rizzuto, Kaori Kanegae, Yasuo Imanishi, Norio Kurumatani, Toshiaki Makino, Chang-Linct Yang, Yutaro Hayashi, Jung Ho Cha, Song Lin, Chul Woo Yang, Won Seok Yang, Marcelo Alarcón, Müjdat Yenicesu, Tsutomu Araki, Gloria A. Preston, O. Iimura, Jorge Isaac, Toshikatsu Shimizu, C. Ito, Can Li, Hirofumi Anai, Tatsuya Nakatani, Shigeo Suzuki, Gabriella Lakos, Cüneyt Ensari, Shoji Nogae, Ottó Árkossy, Vincent Launay-Vacher, R. Ravichandran, K. Tamba, E. Kusano, Shigeru Nakai, Sacit Turanli, Chun-Cheng Hou, Ju Young Jung, Chiew H. Kong, Erzsébet Ladányi, Hyung Wook Kim, Yasuhiro Akai, F. Corica, Koji Harada, Sumiko Homma, Laurence Fardet, Sadayoshi Ito, Abdülgaffar Vural, and Sándor Sipka

Subjects
Medical education, business.industry, Acknowledgement, Medicine, business
Published
1998

7. Editorial / Publisher’s Note

Author

Marcela Vasquez, G. Di Pasquale, Takeshi Suda, Mükerrem Safali, Akihiko Osajima, Petra Marchand, Itsuro Kazama, Sacit Turanli, Hirofumi Matuoka, Chang-Linct Yang, Luigia Costantini, F. Floccari, Tadao Oohara, Shozo Hosokawa, Chiew H. Kong, Yutaro Hayashi, Heinfried H. Radeke, An S. De Vriese, J. Gerth, G. Anastasi, Takahiko Ono, Shigehisa Aoki, Satoru Kawaguchi, Takanobu Sakemi, Sumiko Homma, Sadayoshi Ito, Toshihiko Hata, Katsumi Ito, Mária Takács, Kenji Maeda, Takahiko Nagahama, Kyoko Kitauchi, O. Iimura, Arnold J. Felsenfeld, Jorge Isaac, Masayuki Iwano, Yasuhide Nakashima, Bum Soon Choi, Hidehiro Kakizaki, Masao Kanauchi, Yoshihiko Saito, Masako Iwamoto, G. Cutroneo, Y. Oyama, Qiu Mingcai, Ken Farrington, Toshikatsu Shimizu, Cheri V. Barrett, Fuad S. Shihab, A. Concheiro Guisan, M. Imai, Abdülgaffar Vural, Antonio Nicoletti, Seval Izdes, Masahito Tamura, K. Tamba, Massimino Senatore, Masaaki Inaba, Erzsébet Ladányi, Lesley C Dinwiddie, Yong Soo Kim, Tülin Gümüş, E. Kusano, Toshio Hashimoto, Hyung Wook Kim, Eiji Ishimura, Shin Suda, Tatsuya Nakatani, Yi-Hong Chou, Susan L. Hogan, Jung Ho Cha, Ruriko Nozawa, Marcelo Alarcón, J.A. Camacho Diaz, Magdolna Aleksza, A. Favaloro, Yutaka Imai, Yasuhiro Akai, F. Corica, Yuujiro Watanabe, Chun-Cheng Hou, Shigeo Suzuki, Aquiles Jara, Gabriella Lakos, N. Frisina, Júlia Széll, Ju Young Jung, Wei-Ming Hsu, C. Aloisi, Keiji Fujiwara, Motoshi Hattori, Akane Kurisu, Tsutomu Araki, Yoshiyuki Tomiyoshi, Gilbert Deray, Wan Young Kim, Carla Peona, Akira Owada, Aranka Koós, Magali Ciroldi, Ronald J. Falk, Chul Woo Yang, Chui-Mei Tiu, Kayser Caglar, Koji Harada, Jaime Pereira, Song Lin, Tsung-Hsiu Wang, Katsuya Nonomura, Mari Michimata, Yasushi Asano, Masamiki Miwa, Giuseppe Rizzuto, Naoko Matsumoto, Norio Kurumatani, Seung Hun Lee, Ning Liu, Kaori Kanegae, Jin Kim, Yasuro Kumeda, Huaji Chen, Yasuo Imanishi, Jung Sik Park, Nora Klenk, M. Sommer, A O Phillips, Sang Koo Lee, J. Charles Jennette, Hideo Nakai, Hirofumi Anai, Michele Buemi, Cüneyt Ensari, Attila Nagy, Yoshiki Nishizawa, Toshiaki Makino, Shoji Nogae, Won Seok Yang, Mitsunobu Matsubara, Takao Saruta, Narutoshi Kabashima, Eiji Kusano, Yasuhiro Komatsu, Shigeru Nakai, Ottó Árkossy, Sun Woo Lim, Ryuichiro Konda, Chin-Huang Chen, Soon Bae Kim, Hitoshi Goto, Yukihiko Kawasaki, Takeshi Kanda, Cecilia Chacón, L. Garcia Garcia, J. Vila Cots, Kosei Segawa, T. Rengarajan, Patrizia Colombo, Vincent Launay-Vacher, Yoshiyuki Matsuo, R. Ravichandran, Hitoshi Suzuki, C. Ito, Tomoko Nakamura, Can Li, Y. Watanabe, Wu-Chang Yang, Hassane Izzedine, Tsen-Tsai Chen, Zeki Odabaşi, Yoko Fujino, Eri Muso, Koichiro Homma, M. Suzuki, Jürgen Floege, Paik-Seong Lim, Gisho Honda, Susumu Makino, Xixin Wu, Müjdat Yenicesu, Eveline Sowa, A. Sturiale, Giovanna Piccini, Y. Asano, Gloria A. Preston, A. Romeo, Su-Kil Park, Izzet Yavuz, Masuhisa Nakamura, Mayumi Nagata, Motoaki Miyazono, A. Gimenez Llort, Laurence Fardet, Choung Soo Kim, Bertalan Fodor, David A. Alcorta, Junzo Suzuki, Toshihiko Miwa, Lee-Moi Thien, Nai-Phon Wang, Masahiro Okazaki, Yuri Ozawa, Koichi Hayashi, Enikő Sárváry, A. Ruello, Byung Kee Bang, Sándor Sipka, Satish M. Rao, Iván Palomo, Silvia Pierangeli, Toru Shinzato, U. Eismann, Michiko Suzuki, Hiroshi Shiraga, Oliviero Filiberti, Sigeyuki Takeda, Ulf Janssen, Pasqualina Cecere, Takayuki Ota, Lin Shan, Deniz Ayli, M. Buemi, Yee-Yung Ng, A. Vila Santandreu, G. Stein, and Omac Tufekcioglu

Subjects
business.industry, Medicine, business, Classics
Published
2002

8. Prevalence of Hepatitis C Infection in a Hemodialysis Unit

Author

Carla Peona, A. Mangione, Luigia Costantini, Oliviero Filiberti, C. Monzeglio, Patrizia Colombo, and Porcu M

Subjects
Adult, Male, medicine.medical_specialty, Resuscitation, medicine.medical_treatment, Hepatitis C virus, Hepacivirus, medicine.disease_cause, Gastroenterology, Renal Dialysis, Risk Factors, Internal medicine, Epidemiology, Humans, Medicine, Hepatitis Antibodies, Renal replacement therapy, Seroconversion, Aged, Aged, 80 and over, biology, business.industry, Alanine Transaminase, Hepatitis C, Middle Aged, medicine.disease, Personnel, Hospital, Hemodialysis Units, Hospital, Italy, Immunology, biology.protein, Female, Hemodialysis, Antibody, business
Abstract

To define the prevalence of NANB hepatitis, anti-HCV antibodies were determined in 51 patients on renal replacement therapy, in 7 transplanted patients and 17 staff members of the hemodialysis unit. Anti-HCV antibodies were evaluated using immunoenzymatic methods (Ortho HCV ELISA Test System, 1st and 2nd generation). Among hemodialysis patients, seroconversion was respectively documented in 17.6% (9/51) and 52.9% (27/51); none of the transplanted patients were positive with the 1st generation test, while 3/7 were positive with the 2nd. No statistically significant difference was found in the prevalence antibodies between transfused and nontransfused patients. ALT levels were statistically greater in patients with anti-HCV antibodies (X2 2nd generation = 8.83; p less than 0.01). Our results suggest: (1) that hemodialysis represents a risk factor; (2) the validity of substitute markers and (3) more sensitivity of the 2nd than 1st generation test.

Published
1992

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