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We aimed to explore trends and sociodemographic patterns in benzodiazepine (BZD) (by half-life) and Z-drugs prescribing in Australian general practice.This open cohort study used de-identified electronic health records of 1.4 million patients (50,812,413 consultations) from 402 Australian practices (MedicineInsight 2011-2018). Annual prescribing frequency and changes over time were estimated according to sex, age, socioeconomic position and rurality.Between 2011 and 2018, the prescribing of very short-acting BZD increased from 0.10 to 0.29 per 1000 consultations (average annual change +17.2% [95% CI 9.6; 25.3]), while it declined for short-intermediate (from 38.5 to 26.6 per 1000 consultations; annual change -5.1% [95% CI -5.6; -4.5]), long-acting BZD (from 24.1 to 21.6 per 1000 consultation; annual change -1.5% [95% CI -2.2; -0.8]) and Z-drugs (from 4.6 to 4.0 per 1000 consultations; annual change -1.9% [95% CI -3.0; -0.7]). Short-intermediate-acting BZD prescribing was three times more frequent among women aged 65+ years than younger women, and long-acting BZD three-to-four times more likely among younger than older men. Z-drugs prescribing was higher among women aged 45-64 years than younger or older females. Short-intermediate- and long-acting BZD were more likely prescribed for patients from more disadvantaged areas, and Z-drugs in more advantaged areas. There were no disparities by rurality.Although most BZD and Z-drugs prescriptions declined over time, short-intermediate BZD prescriptions remained higher among older women and long-acting BZD more frequent among younger men, especially for those living in more disadvantaged areas. Targeted interventions could reduce the prescribing of BZD and Z-drugs in these groups.

Introdução: As lesões nervosas periféricas (LNP) podem resultar em distúrbios motores e sensoriais alterando a funcionalidade do membro afetado, porém pouco se conhece a respeito dos efeitos da fotobiomodulação (FBM) com diodo emissor de luz (LED). Objetivo: Analisar os efeitos do LED sobre a funcionalidade da marcha de ratos Wistar pós LNP. Metodologia: Ratos Wistar foram submetidos a LNP por esmagamento de ciático e analisados nos seguintes grupos experimentais: (1) Controle; (2) LNP; (3) LNP+ LED (780 nm, potência média 40 mW, exposição radiante, energia por ponto, 3,2 J sobre o nervo ciático (LEDn); (4) LNP+ LED em nervo e região do músculo envolvido (LEDnm) e (5) LNP+ LED apenas em região do músculo (LEDm). Após 7, 14, 21 e 28 dias foram realizadas as análises de marcha utilizando o Índice Funcional Ciático (IFC). Resultado: Após 7 dias, os grupos tratados com LED apresentaram uma melhora da marcha em relação ao grupo Lesão, sendo essa melhora mais pronunciada no grupo LEDn. Após 14 dias, os grupos LEDn e LEDnm apresentaram valores semelhantes ao grupo controle e após 21 e 28 dias o IFC não apresentou diferenças entre os grupos experimentais. Conclusão: O LED aumentou a funcionalidade da marcha avaliada pelo IFC após 1 e 2 semanas pós LNP, especialmente quando foi usado na região nervosa associada ou não à região muscular.

Ozonation has been used to degrade persistent water contaminants, namely, pharmaceuticals and personal care products (PPCPs). However, ozonation can lead to by-products that can be more toxic than the parent compounds. This work aims to assess whether the ecotoxicological effects of ozonation are modified as the initial matrix being treated increases in complexity, considering mixtures of 2, 3, 4 and 5 PPCPs. The following PPCPs were used: two parabens (metylparaben (MP) and propylparaben (PP)), paracetamol (PCT), sulfamethoxazole (SMX) and carbamazepine (CBZ). The following model species were used to assess toxicity: the crustacean Daphnia magna, the microalgae Raphidocelis subcapitata, the macrophyte Lemna minor and the watercress Lepidium sativum. There was a trend of increased toxicity with increasing mixture complexity of the untreated samples, except for D. magna. The same was observed after ozonation with the exception of the mixture MP+PP, which showed high toxicity to all the tested species, namely 100% immobilization of D. magna. The toxicity of SMX to the primary producers decreased pronouncedly after ozonation, except for L. minor. This study highlights the importance of considering the complexity of the matrix being treated and of using an ecotoxicological test battery with a wide diversity of species for assessing ozonation efficiency.

ObjectivesThis study investigated whether the monitoring and control of clinical parameters are better among patients with newly compared with past recorded diabetes diagnosis.DesignRetrospective cohort study.SettingMedicineInsight, a national general practice database in Australia.Participants101 875 ‘regular’ adults aged 18+ years with past recorded (2015–2016) and 9236 with newly recorded (2017) diabetes diagnosis.Main outcome measuresTwo different groups of outcomes were assessed in 2018. The first group of outcomes was the proportion of patients with clinical parameters (ie, glycated haemoglobin A1c (HbA1c), blood pressure (BP), total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglycerides, estimated glomerular filtration rate and albumin-to-creatinine ratio) monitored at least once in 2018. The second group of outcomes were those related to diabetes control in 2018 (HbA1c ≤7.0%, (BP) ≤140/90 mm Hg, total cholesterol adj) and adjusted probabilities (%) were obtained based on logistic regression models adjusted for practice variables and patients’ socio-demographic and clinical characteristics.ResultsThe study included 111 111 patients (51.7% men; mean age 65.3±15.0 years) with recorded diabetes diagnosis (11.0% of all 1 007 714 adults in the database). HbA1c was monitored in 39.2% (95% CI 36.9% to 41.6%) of patients with newly recorded and 45.2% (95% CI 42.6% to 47.8%) with past recorded diabetes (ORadj0.78, 95% CI 0.73 to 0.82). HbA1c control was achieved by 78.4% (95% CI 76.7% to 80.0%) and 54.4% (95% CI 53.4% to 55.4%) of monitored patients with newly or past recorded diabetes, respectively (ORadj3.11, 95% CI 2.82 to 3.39). Less than 20% of patients with newly or past recorded diabetes had their HbA1c, BP and total cholesterol levels controlled (ORadj1.08, 95% CI 0.97 to 1.21).ConclusionsThe monitoring of clinical parameters was lower among patients with newly than past recorded diabetes. However, diabetes control was similarly low in both groups, with only one in five monitored patients achieving control of all clinical parameters.

Objectives. The use of Facebook (FB) to share and gather information on diabetes is commonplace but no data is available on its use among Filipinos during the COVID-19 pandemic. We sought to determine the engagement from instructional slide decks on diabetes and its management shown on two Philippine-based FB pages under the Enhanced Community Quarantine (ECQ). Methodology. We used Insights data from the slide decks and slide shows shown on the Philippine Society ofEndocrinology, Diabetes and Metabolism’s (PSEDM) public FB page and the Endocrine Witch’s FB page. The slide set contained a mix of mostly images and text on COVID-19 and Diabetes, dietary advice, medications and self-care in the setting of the ECQ where access to insulin, ambulatory clinics and healthy food is limited. Data was summarized in terms of post clicks, reactions, shares and comments. Total engagement rate was computed. Results. We noted a high engagement rate (4-15%) in both public FB pages with higher engagement rates in slides shown in the Filipino language for most topics. The slides that gathered more shares and reactions were primarily those containing general information on COVID-19 and diabetes, nutrition including the safety of canned goods, as well as sick day rules. Conclusion. In the setting of the ECQ, the use of image and text-based slide-decks on the PSEDM and Endocrine Witch FB pages to communicate health information yielded high engagement.

*Visual Abstract by Dr. Jerico Gutierrez Objective. This study assessed whether short message service (SMS) reminders would improve follow-up rate among gestational diabetes mellitus (GDM) patients by 12 weeks postpartum. Methodology. In this single-center, single-blind randomized controlled trial, we assigned 308 patients with GDM to either of 2 arms, usual care alone versus usual care with SMS reminders. In the usual care group, 154 patients received a 10-minute short lecture on GDM and a 75 g oral glucose tolerance test (OGTT) request prior to discharge. In the SMS group, 154 patients received twice a week SMS reminders at 4 weeks, 8 weeks, and 10 weeks after delivery in addition to usual care. The primary outcome was clinic visit within 6 to 12 weeks postpartum with a 75 g OGTT result. Results. In our population, the overall follow-up rate was 19.8% (61/308). Follow up rates were 20.1% (31/154) for the usual care group and 19.5% (30/154) for the SMS. The addition of SMS reminders was not associated with an increase in follow-up rate at 12 weeks postpartum (adjusted RR 0.98, 95% CI 0.63-1.52; p =0.932). The use of insulin or metformin for GDM control was associated with increased follow-up (adjusted RR 1.92, 95% CI 1.20-3.07; p =0.006). Conclusion. SMS reminders did not improve postpartum follow-up rate among GDM patients at 12 weeks postpartum.

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-11-05T20:17:17Z No. of bitstreams: 1 Carla Bernardo Soldera.pdf: 2530684 bytes, checksum: 44fa94c5fefa5b1c49cdb29fa6424f61 (MD5) Made available in DSpace on 2021-11-05T20:17:17Z (GMT). No. of bitstreams: 1 Carla Bernardo Soldera.pdf: 2530684 bytes, checksum: 44fa94c5fefa5b1c49cdb29fa6424f61 (MD5) Previous issue date: 2020-12-17 Contextualization: Traumatic injuries of the peripheral nervous system are common today, being an important medical problem. The aim of the present study was to evaluate the effects of immediate exercise associated with photobiomodulation therapy using LED as a rehabilitation after peripheral nerve injury by crushing the sciatic nerve in Wistar rats. Methodology: 45 Wistar rats were used, randomly divided into 5 groups: Control; Injury; Injury+LEDn+Exercise; Injury+LEDnm+Exercise; Injury+Exercise. The animals were euthanized 7 and 14 days after the operation. Photobiomodulation therapy consisted of the use of 850nm LED, 1cm2 beam area (nerve region total of 4 points, energy per point 0.8J, time per point of 20sec, total energy 3.2J and muscle region total of 8 points, energy per point 0.4J, time per point 10sec, total energy 3.2J), in a punctual way in contact with the animal's skin, with daily applications for 5 consecutive days, starting 2h after the crush injury. For exercise training, a treadmill adapted for training with rats containing lanes and digital speed control was used. The exercise protocol consisted of daily training started 24 hours after the operation, being performed 30 minutes/day, five days a week, without inclination. After each experimental period, functional analysis of gait was performed using the functional sciatic index, analysis of mechanical hyperalgesia using the Von Frey test, analysis of muscle mass to assess muscle atrophy, qualitative and quantitative assessment of muscle morphological aspects and qualitative analysis and quantitative of collagen fibers. Results: Regarding gait assessment, all injured groups showed a worsening in the functional index assessed after 7 and 14 days of injury, and it was observed in 7 days that the Injury+LEDn+Exercise group performed better when compared to the others. injured and treated groups. In 14 days, the Injury+LEDn+Exercise group performed better when compared to the Injury group. Regarding the analysis of muscle mass, after 7 days, all injured groups, treated or not, showed a decrease in the muscle mass ratio indicating an increase in atrophy when compared to the Control group, and the same occurred in 14 days. The Injury+LEDn+Exercise group in 14 days showed an improvement when compared to the Lesion group indicating less muscle atrophy. Regarding hyperalgesia, in the period of 7 and 14 days all injured groups, treated or not, showed a decrease in nociception in relation to the Control group. In 14 days, the Injury+LEDn+Exercise and Injury+LEDnm+Exercise groups showed better results when compared to the Injury group. It was also shown that in the same period that the injured and treated groups with LED both in the nerve region and in the nerve and muscle associated with exercise showed better results when compared to the Injury+Exercise group only. Conclusion: Based on the results, it was possible to conclude that the use of photobiomodulation when applied to the nervous region associated with early-onset exercise can contribute to a functional improvement in gait, reduces muscle atrophy and acts positively on nociception. Contextualização: Lesões traumáticas do sistema nervoso periférico são comuns atualmente, sendo um importante problema médico. O objetivo do presente estudo foi avaliar os efeitos do exercício imediato associado a terapia de fotobiomodulação utilizando LED como reabilitação após lesão nervosa periférica por esmagamento do nervo ciático em ratos Wistar. Metodologia: Foram utilizados 45 ratos da linhagem Wistar, divididos aleatoriamente em 5 grupos: Controle; Lesão; Lesão+LEDn+Exercício; Lesão+LEDnm+Exercício; Lesão+Exercício. Os animais foram eutanasiados em 7, 14 dias de pós-operatório. A terapia de fotobiomodulação consistiu no uso de LED 850 nm, área do feixe de 1cm2 (região nervosa total de 4 pontos, energia por ponto 0,8J, tempo por ponto de 20seg, energia total 3.2J e região muscular total de 8 pontos, energia por ponto 0,4J, tempo por ponto de 10seg, energia total 3.2J), de forma pontual em contato com a pele do animal, com aplicações diárias por 5 dias consecutivos, iniciando 2h após a lesão por esmagamento. Para o treino de exercício, foi utilizada esteira ergométrica adaptada para o treino com ratos contendo raias e controle digital de velocidade. O protocolo de exercício consistiu em treinos diários iniciados após 24horas de pós- operatório sendo realizado 30min/dia, cinco dias por semana, sem inclinação. Após cada período experimental foi realizado a análise funcional da marcha através do índice funcional do ciático, análise da hiperalgesia mecânica através do teste de Von Frey, análise da massa muscular para avaliar a atrofia muscular, avaliação qualitativa e quantitativa dos aspectos morfológicos musculares e análise qualitativa e quantitativa das fibras colágenas. Resultados: Em relação a avaliação da marcha, todos os grupos lesionados apresentaram uma piora no índice funcional avaliado após 7 e 14 dias de lesão, sendo observado em 7 dia que o grupo Lesão+LEDn+Exercício apresentou um melhor desempenho quando comparado com os demais grupos lesionados e tratados. Já em 14 dias o grupo Lesão+LEDn+Exercício apresentou um melhor desempenho quando comparado ao grupo Lesão. No que se diz respeito a análise da massa muscular, após 7 dias, todos os grupos lesionados, tratados ou não demonstraram uma diminuição da relação de massa muscular indicando aumento de atrofia quando comparado ao grupo Controle, sendo que o mesmo ocorreu em 14 dias. O grupo Lesão+LEDn+Exercício em 14 dias demonstrou uma melhora quando comparado ao grupo Lesão indicando uma menor atrofia muscular. Em relação a hiperalgesia, no período de 7 e 14 dias todos os grupos lesionados, tratados ou não demonstraram uma diminuição na nocicepção em relação ao grupo Controle. Já em 14 dias, os grupos Lesão+LEDn+Exercício e Lesão+LEDnm+Exercício apresentaram melhores resultados quando comparados ao grupo Lesão. Foi demonstrado também que no mesmo período que os grupos lesionados e tratados com LED tanto na região nervosa como nervo e músculo associado ao exercício apresentaram melhores resultados quando comparados ao grupo Lesão+Exercício apenas. Conclusão: Com base nos resultados, é possível concluir que o uso da fotobiomodulação quando aplicada na região nervosa associada ao exercício de início precoce pode contribuir para uma melhora funcional da marcha, reduz a atrofia muscular e atua positivamente na nocicepção.

Introduction Hyperglycemia occurs in Acute Lymphoblastic Leukemia (ALL) due to chemotherapeutic agents and may be stress-induced. Given the potential impact of hyperglycemia on the clinical outcomes of ALL patients, we sought to determine the association of hyperglycemia with the development of infectious complications. Methods This is a retrospective cohort involving adult Filipino ALL patients admitted at a tertiary referral center. Patients were stratified according to blood glucose levels and infections were classified into microbiologically and clinically defined infections. Logistic regression was performed to determine whether hyperglycemia was associated with the development of infectious complications. Results Of the 174 patients admitted for ALL, only 76 patients (44%) underwent blood glucose monitoring and were thus included in this study. Hyperglycemia was observed in 64 patients (84.21%). Infectious complications were seen in 56 patients (73.68%), of whom 37 patients (48.68%) had microbiologically defined infections and 19 (25%) had clinically defined infections. The respiratory tract was the most common site of infection and gram-negative bacteria were the predominant isolates. Hyperglycemia significantly increased the likelihood of infectious complications, particularly at blood glucose levels ≥ 200 mg/dL. Conclusion Hyperglycemia is associated with an increased likelihood of infectious complications in Filipino ALL patients. With sepsis being one of the main causes of mortality in this population, our study provides compelling evidence for us to consider routine blood glucose monitoring in order to manage and potentially decrease the occurrence of infections in these patients.

The School Restaurant Eco Sol Bistro is an extension project developed in the Incubatorof Social and Solidary Technologies of the Federal University of Grande Dourados(ITESS/UFGD), in partnership with the Nutrition Course, together with settlers ofAgrarian Reform and Quilombo, coming from entrepreneurship groups based on theprinciples of Solidary Economy, which lacked specific actions with respect to applied knowledge on gastronomy, meal production and food service management, withconsumer safety security and as a possibility to generate income. The project benefitsboth this audience and the academic community. Structured on the quality tripodhygienic-sanitary, sensory and nutritional), ambience and cost, it operates since October2014. With lunch service, it uses food from family farming, mostly organic food,ensuring five colors of fruits and vegetables a day, natural juice, homemade desserts anda typical dish. The joint teaching-research includes academic students from the Mastersin Agribusiness and Graduation in Nutrition. It is expected that at the end of two years,entrepreneurs are prepared to implement a similar service in their communities,providing income generation, social inclusion, dissemination of Solidary Economyprinciples and sustainable local development. O Restaurante Escola Bistrô Eco Sol é um projeto de extensão desenvolvido naIncubadora de Tecnologias Sociais e Solidárias da Universidade Federal da GrandeDourados (ITESS/UFGD), em parceria com o Curso de Nutrição,junto a Assentados daReforma Agrária e Quilombolas, oriundos de grupos de empreendedorismo, baseadonos princípios da Economia Solidária, que careciam de ações específicas no que tange aconhecimentos aplicados de Gastronomia, produção de refeições e gestão de serviços dealimentação, com garantia de segurança do consumidor e como possibilidade de geraçãode renda. O projeto beneficia, tanto esse público, quanto a comunidade acadêmica.Estruturado no tripé qualidade (higênico-sanitária, sensorial e nutricional), ambiência ecusto, funciona desde outubro de 2014.Com serviço de almoço, utiliza alimentos daagricultura familiar, em sua maioria orgânicos, garantindo cinco cores de frutas ehortaliças ao dia, suco natural, sobremesas caseiras e um prato típico. No vínculoensino-pesquisa, se incluem acadêmicos de Mestrado em Agronegócios e de Graduaçãoem Nutrição. O esperado é que, ao final de dois anos,as empreendedoras estejampreparadas para implantar um serviço semelhante em suas comunidades,proporcionando geração de renda, inclusão social, disseminação dos princípios daEconomia Solidária e desenvolvimento local sustentável.

O Restaurante Escola Bistrô Eco Sol é um projeto de extensão desenvolvido na Incubadora de Tecnologias Sociais e Solidárias da Universidade Federal da Grande Dourados (ITESS/UFGD), em parceria com o Curso de Nutrição,junto a Assentados da Reforma Agrária e Quilombolas, oriundos de grupos de empreendedorismo, baseado nos princípios da Economia Solidária, que careciam de ações específicas no que tange a conhecimentos aplicados de Gastronomia, produção de refeições e gestão de serviços de alimentação, com garantia de segurança do consumidor e como possibilidade de geração de renda. O projeto beneficia, tanto esse público, quanto a comunidade acadêmica. Estruturado no tripé qualidade (higênico-sanitária, sensorial e nutricional), ambiência e custo, funciona desde outubro de 2014.Com serviço de almoço, utiliza alimentos da agricultura familiar, em sua maioria orgânicos, garantindo cinco cores de frutas e hortaliças ao dia, suco natural, sobremesas caseiras e um prato típico. No vínculo ensino-pesquisa, se incluem acadêmicos de Mestrado em Agronegócios e de Graduação em Nutrição. O esperado é que, ao final de dois anos,as empreendedoras estejam preparadas para implantar um serviço semelhante em suas comunidades, proporcionando geração de renda, inclusão social, disseminação dos princípios da Economia Solidária e desenvolvimento local sustentável.

Objective This study aims to determine the convergent and discriminant validity and internal consistent reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Tagalog among adult Filipinos with differentiated thyroid cancer (DTC). Methodology 104 adult Filipinos with DTC at various disease stages self-administered the EORTC QLQ-C30 version 3 Tagalog and Short Form-36 (SF-36) version 2 Tagalog. Concurrent validity between conceptually-related scales from both tools was determined. Convergent and discriminant validity of multi-item scales of the EORTC QLQ-C30 Tagalog were assessed by Spearman’s correlation. Cronbach's α was computed. Results The EORTC QLQ-C30 Tagalog showed moderate correlation with similar scales in the SF-36 Tagalog particulary for physical, role and social functioning, pain, and global health (r=0.42-0.48, p

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-07-18T21:12:26Z No. of bitstreams: 1 Carla Bernardo Soldera.pdf: 1125219 bytes, checksum: a9bf43bd0d44898b4a48ec77b3f45001 (MD5) Made available in DSpace on 2018-07-18T21:12:26Z (GMT). No. of bitstreams: 1 Carla Bernardo Soldera.pdf: 1125219 bytes, checksum: a9bf43bd0d44898b4a48ec77b3f45001 (MD5) Previous issue date: 2017-12-15 Peripheral nerve lesions (LNP) do not clinically present a risk of death to the individual but may result in motor and sensory disturbances altering the function of the affected limb. Phototherapy using low level laser has demonstrated positive effects for the nervous and muscle repair process after different types of injury and little is known about the effects of light emitting diode (LED) therapy. Objective: To analyze the effects of LED on the nervous and muscular repair of Wistar rats after sciatic nerve crush injury. Methodology: 85 Wistar rats, weighing 200-250g, in 5 groups: Control: without any procedure; Injury: carried out only the crushing of the Left Sciatic Nerve (LSN); Injury + LEDn: LSN crushing and LED irradiation in the area corresponding to the nerve injury; Injury + LEDmm: LSN and LED crushing in Tibial Anterior muscle; Injury + LEDn + LEDmm: NSE crushing and LED irradiation in the area corresponding to nerve injury and muscle. The application of the LED in the nervous region was performed with the following parameters: wavelength of 808nm, beam area 1 cm2, average power 40Mw, power density 0.04 W/cm2, energy density 0.8 J/cm2, energy per point 0.8J , total of points 4, time per point 20sec, total time 80sec, energy per point 3.2J and in muscle region was used wavelength of 808nm, beam area 1 cm2, average power 40Mw, power density 0.04 W/ cm2, density of energy 0.4 J/ cm2, energy per point 0.4J, total of points 8, time per point 10sec, total time 80sec, energy per point 3.2J. At the end of the experimental periods, the gait analysis and the mechanical hyperalgesia test were performed. At the end of the experimental periods, gait analysis was performed using the Sciatic Function Index (IFC), as well as the analysis of mechanical hyperalgesia using the von Frey test using the pressure analgesimeter with transducer. After the euthanasia of the animals, the tibial muscles, left and right, were removed and weighed in a semi-analytical balance to determine the degree of muscular atrophy and the muscle mass ratio was calculated. Result: After the IFC, within 7 days, all groups treated with LED showed an improvement in gait compared to the lesion group. The group LEDn was the one that presented the best result compared to the control group. After 14 days, the group LEDn and LEDnm presented similar values to the control group. Regarding the muscular atrophy index, in the 7-day period, all the groups treated with LED showed a decrease of the index in relation to the Control group. In 14 days, the LED groups showed an increase in relation to the Injury group. At 21 and 28 days, the injured groups showed a decrease in relation to the Control group. Only the LEDnm group showed a decrease compared to the Injury group. Regarding mechanical hyperalgesia, the results showed that in 7 days, the LEDn group was the one that presented the best result compared to the control group. At 14 days, the LEDn and LEDm groups showed an increase in the threshold, requiring a greater pressure to promote an allergic response compared to the control group, making them more resistant to the stimuli. At 28 days, all lesioned and treated groups showed an increase in hyperalgesia in relation to the control group. Conclusion: We can conclude that LED increased gait functionality assessed by IFC after 1 and 2 weeks post LNP, especially when it was used in the nerve region associated or not to the muscle region, induced an increase in muscle mass in relation to the animals that did not receive treatment in the period of 2 weeks post LNP and in the 2 week period post LNP provided an increase in the pain threshold compared to the control group, requiring a nociceptive stimulus of greater intensity to generate the pain stimulus indicating a better recovery. As les??es nervosas perif??ricas (LNP) n??o apresentam clinicamente um risco de morte ao indiv??duo, por??m podem resultar em dist??rbios motores e sensoriais alterando a funcionalidade do membro afetado. A fototerapia utilizando laser de baixa pot??ncia (LBP) tem demonstrado efeitos positivos para o processo de reparo nervoso e muscular ap??s diferentes tipos de les??o e pouco se conhece a respeito dos efeitos da terapia com diodo emissor de luz (LED, do ingl??s light emitting diode). Objetivo: Analisar os efeitos do LED sobre o reparo nervoso e muscular de ratos Wistar p??s les??o por esmagamento do nervo ci??tico. Metodologia: foram utilizados 85 ratos Wistar, pesando 200-250g, em 5 grupos: Controle: sem nenhum procedimento; Les??o: realizado apenas o esmagamento do Nervo Ci??tico Esquerdo (NCE); Les??o+LEDn: esmagamento do NCE e irradia????o LED na ??rea correspondente ?? les??o nervosa; Les??o+LEDm: esmagamento do NCE e LED no m??sculo Tibial Anterior; Les??o+LEDnm: esmagamento do NCE e irradia????o LED na ??rea correspondente ?? les??o nervosa e m??sculo. A aplica????o do LED em regi??o nervosa foi realizada com os seguintes par??metros: comprimento de onda de 808nm, ??rea do feixe 1cm2, pot??ncia m??dia 40Mw, densidade de pot??ncia 0.04W/ cm2, densidade de energia 0.8 J/cm2, energia por ponto 0.8J, total de pontos 4, tempo por ponto 20seg, tempo total 80seg, energia por ponto 3.2J e em regi??o muscular foi utilizado comprimento de onda de 808nm, ??rea do feixe 1cm2, pot??ncia m??dia 40Mw, densidade de pot??ncia 0.04W/ cm2, densidade de energia 0.4 J/cm2, energia por ponto 0.4J, total de pontos 8, tempo por ponto 10seg, tempo total 80seg, energia por ponto 3.2J. Ao t??rmino dos per??odos experimentais, foi realizada a an??lise de marcha utilizando o ??ndice Funcional Ci??tico (IFC), bem como a an??lise da hiperalgesia mec??nica atrav??s do teste de von Frey utilizando o analges??metro de press??o com transdutor. Ap??s a eutan??sia dos animais os m??sculos Tibial Anterior direito e esquerdo foram removidos e pesados em uma balan??a semi-anal??tica para determina????o do grau de atrofia muscular sendo calculada a rela????o de massa muscular. Resultado: Ap??s a realiza????o do IFC, no per??odo de 7 dias, todos os grupos tratados com LED apresentaram uma melhora da marcha em rela????o ao grupo Les??o. O grupo LEDn foi o que apresentou o melhor resultado comparado ao grupo controle. Ap??s 14 dias, o grupo LEDn e LEDnm apresentaram valores semelhantes ao grupo controle. J?? em rela????o ao ??ndice de atrofia muscular, no per??odo de 7 dias, todos os grupos tratados com LED demonstraram uma diminui????o do ??ndice em rela????o ao grupo Controle. Em 14 dias, os grupos LED demonstraram um aumento em rela????o ao grupo Les??o. Em 21 e 28 dias, os grupos lesionados demonstraram uma diminui????o em rela????o ao grupo Controle. Apenas o grupo LEDnm apresentou uma diminui????o em rela????o ao grupo Les??o. No que diz respeito a hiperalgesia mec??nica, os resultados obtidos demonstraram que em 7 dias, o grupo LEDn foi o que apresentou o melhor resultado comparado ao grupo controle. Em 14 dias, os grupos LEDn e LEDm apresentaram um aumento no limiar sendo necess??rio uma press??o maior para promover uma resposta ??lgica comparados ao grupo controle, tornando-os mais resistentes aos est??mulos. Em 28 dias todos os grupos lesionados e tratados apresentaram um aumento da hiperalgesia em rela????o ao grupo controle. Conclus??o: O LED aumentou a funcionalidade da marcha avaliada pelo IFC ap??s 1 e 2 semanas p??s LNP, especialmente quando foi usado na regi??o nervosa associada ou n??o ?? regi??o muscular, induziu um aumento na massa muscular em rela????o aos animais que n??o receberam tratamento no per??odo de 2 semanas p??s LNP e proporcionou um aumento no limiar ??lgico comparado ao grupo controle no per??odo de 2 semanas p??s LNP, sendo necess??rio um est??mulo nociceptivo de maior intensidade para gerar o est??mulo doloroso indicando uma melhor recupera????o.