167 results on '"Carioli G."'
Search Results
2. T.07.10: BACTERIAL AND FUNGAL INFECTIONS INACLF: PREVALENCE AND IMPACT ON PATIENT MORBIDITY AND MORTALITY
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Iegri, C., primary, Ideo, F., additional, Tebaldi, A., additional, Viganò, M., additional, Farina, E., additional, Carioli, G., additional, Lucà, M.G., additional, Pasulo, L., additional, Triolo, M., additional, Leonardi, F., additional, Mangia, G., additional, Pinelli, D., additional, Camagni, S., additional, Colledan, M., additional, and Fagiuoli, S., additional
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- 2024
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3. OC.11.8: SHORT- AND LONG-TERM RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH ALCOHOLIC LIVER DISEASE (ALD) AND ACUTE ON CHRONIC LIVER FAILURE
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Iegri, C., primary, Ideo, F., additional, Viganò, M., additional, Farina, E., additional, Carioli, G., additional, De Giorgio, M., additional, Pasulo, L., additional, Leonardi, F., additional, Loglio, A., additional, Guizzetti, M., additional, Zambelli, M., additional, Pinelli, D., additional, Colledan, M., additional, and Fagiuoli, S., additional
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- 2024
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4. OC.11.4: LIVER TRANSPLANT IN ACLF AND ALD: AN EFFECTIVE OPTION WITH LIMITED ACCESS? PRELIMINARY RESULTS OF A SINGLE CENTER EXPERIENCE
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Ideo, F., primary, Iegri, C., additional, Viganò, M., additional, Farina, E., additional, Merisio, A., additional, Carioli, G., additional, Lucà, M.G., additional, Pasulo, L., additional, Triolo, M., additional, Pinelli, D., additional, Neri, F., additional, Colledan, M., additional, and Fagiuoli, S., additional
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- 2024
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5. European cancer mortality predictions for the year 2021 with focus on pancreatic and female lung cancer
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Carioli, G., Malvezzi, M., Bertuccio, P., Boffetta, P., Levi, F., La Vecchia, C., and Negri, E.
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- 2021
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6. European cancer mortality predictions for the year 2020 with a focus on prostate cancer
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Carioli, G., Bertuccio, P., Boffetta, P., Levi, F., La Vecchia, C., Negri, E., and Malvezzi, M.
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- 2020
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7. EP06.05-06 Distant Metastasis Pattern and Baseline Clinicopathological Features from a Real-World KRAS G12C Mutant Cohort of Advanced NSCLC Patients
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Mollica, L., primary, Intagliata, S., additional, Bonomi, L., additional, Ghilardi, L., additional, Morotti, D., additional, Ghirardi, G., additional, Antelmi, E., additional, Gianatti, A., additional, Carioli, G., additional, Muglia, R., additional, Marra, P., additional, Raimondi, F., additional, Ciaravino, G., additional, Di Marco, F., additional, Sironi, S., additional, Tondini, C.A., additional, and Bettini, A.C., additional
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- 2023
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8. One-year mortality in COVID-19 is associated with patients’ comorbidities rather than pneumonia severity
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Novelli, L, Raimondi, F, Carioli, G, Carobbio, A, Pappacena, S, Biza, R, Trapasso, R, Anelli, M, Amoroso, M, Allegri, C, Malandrino, L, Imeri, G, Conti, C, Beretta, M, Gori, M, D'Elia, E, Senni, M, Lorini, F, Rizzi, M, Cosentini, R, Rambaldi, A, Masciulli, A, Gavazzi, A, Solidoro, P, Sironi, S, Fagiuoli, S, Barbui, T, Marco, F, Novelli L., Raimondi F., Carioli G., Carobbio A., Pappacena S., Biza R., Trapasso R., Anelli M., Amoroso M., Allegri C., Malandrino L., Imeri G., Conti C., Beretta M., Gori M., D'Elia E., Senni M., Lorini F. L., Rizzi M., Cosentini R., Rambaldi A., Masciulli A., Gavazzi A., Solidoro P., Sironi S., Fagiuoli S., Barbui T., Marco F. D., Novelli, L, Raimondi, F, Carioli, G, Carobbio, A, Pappacena, S, Biza, R, Trapasso, R, Anelli, M, Amoroso, M, Allegri, C, Malandrino, L, Imeri, G, Conti, C, Beretta, M, Gori, M, D'Elia, E, Senni, M, Lorini, F, Rizzi, M, Cosentini, R, Rambaldi, A, Masciulli, A, Gavazzi, A, Solidoro, P, Sironi, S, Fagiuoli, S, Barbui, T, Marco, F, Novelli L., Raimondi F., Carioli G., Carobbio A., Pappacena S., Biza R., Trapasso R., Anelli M., Amoroso M., Allegri C., Malandrino L., Imeri G., Conti C., Beretta M., Gori M., D'Elia E., Senni M., Lorini F. L., Rizzi M., Cosentini R., Rambaldi A., Masciulli A., Gavazzi A., Solidoro P., Sironi S., Fagiuoli S., Barbui T., and Marco F. D.
- Abstract
Background: In patients with pneumonia or acute respiratory distress syndrome who survived hospitalization, one-year mortality can affect up to one third of discharged patients. Therefore, significant long-term mortality after COVID-19 respiratory failure could be expected. The primary outcome of the present study was one-year all-cause mortality in hospitalized COVID-19 patients. Methods: Observational study of COVID-19 patients hospitalized at Papa Giovanni XXIII Hospital (Bergamo, Italy), during the first pandemic wave. Results: A total of 1326 COVID-19 patients were hospitalized. Overall one-year mortality was 33.6% (N 446/1326), with the majority of deaths occurring during hospitalization (N=412, 92.4%). Thirty-four patients amongst the 914 discharged (3.7%) subsequentely died within one year. A third of these patients died for advanced cancer, while death without a cause other than COVID-19 was uncommon (8.8% of the overall post-discharge mortality). In-hospital late mortality (i.e. after 28 days of admission) interested a population with a lower age, and fewer comorbidities, more frequentely admitted in ICU. Independent predictors of post-discharge mortality were age over 65 years (HR 3.19; 95% CI 1.28-7.96, p-value=0.013), presence of chronic obstructive pulmonary disease (COPD) (HR 2.52; 95% CI 1.09-5.83, p-value=0.031) or proxy of cardiovascular disease (HR 4.93; 95% CI 1.45-16.75, p-value=0.010), and presence of active cancer (HR 3.64; 95% CI 1.50-8.84, p-value=0.004), but not pneumonia severity. Conclusions: One-year post-discharge mortality depends on underlying patients’ comorbidities rather than COVID-19 pneumonia severity per se. Awareness among physicians of predictors of post-discharge mortality might be helpful in structuring a follow-up program for discharged patients.
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- 2023
9. Paediatric porto-sinusoidal vascular disease: Two different clinical phenotypes with subtle histological differences
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Digiorgio, A, Matarazzo, L, Sonzogni, A, Nicastro, E, Pietrobattista, A, Cananzi, M, Gaio, P, Sciveres, M, Dileo, G, Iorio, R, Marseglia, A, Carioli, G, Maggiore, G, Guido, M, D'Antiga, L, DiGiorgio A., Matarazzo L., Sonzogni A., Nicastro E., Pietrobattista A., Cananzi M., Gaio P., Sciveres M., DiLeo G., Iorio R., Marseglia A., Carioli G., Maggiore G., Guido M., D'Antiga L., Digiorgio, A, Matarazzo, L, Sonzogni, A, Nicastro, E, Pietrobattista, A, Cananzi, M, Gaio, P, Sciveres, M, Dileo, G, Iorio, R, Marseglia, A, Carioli, G, Maggiore, G, Guido, M, D'Antiga, L, DiGiorgio A., Matarazzo L., Sonzogni A., Nicastro E., Pietrobattista A., Cananzi M., Gaio P., Sciveres M., DiLeo G., Iorio R., Marseglia A., Carioli G., Maggiore G., Guido M., and D'Antiga L.
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Background and Aims: In paediatrics, porto-sinusoidal vascular disease (PSVD) is relatively unknown and probably underdiagnosed. We aimed to describe clinical phenotypes, histology and outcome of children diagnosed with PSVD. Methods: Retrospective multicentre study of children diagnosed with PSVD. Diagnosis of PSVD was based on histopathology reports; liver specimens were re-evaluated by two expert liver pathologists. Results: Sixty two children diagnosed with PSVD (M/F = 36/26, median age 6.6 years, range 3.3–10.6), from 7 centres, were included. Thirty-six presented with non-cirrhotic portal hypertension, PH, (PH-PSVD Group = 58%) while 26 had a liver biopsy because of chronic elevation of transaminases without PH (noPH-PSVD Group = 42%). On histology review, the two groups differed for the prevalence of obliterative portal venopathy (more prevalent in PH-PSVD, p = 0.005), and hypervascularised portal tracts (more common in noPH-PSVD, p = 0.039), the other histological changes were equally distributed. At multivariate analysis, platelet count ≤185 000/mm3 was the only independent determinant of PH (p < 0.001). After a median follow-up of 7 years (range 3.0–11.2), in PH-PSVD group 3/36 (8%) required TIPS placement, 5/36 (14%) developed pulmonary vascular complications of PH, and 7/36 (19%) required liver transplantation. In noPH-PSVD none progressed to PH nor had complications. Conclusions: Paediatric patients with PSVD present with two different clinical phenotypes, one characterised by PH and one by chronic elevation of transaminases without PH. PSVD should be included among the conditions causing isolated hypertransaminasaemia. On histology, the differences between the two groups are subtle. Medium-term outcome is favourable in patients without PH; progression of the disease is observed in those with PH.
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- 2023
10. Cancer mortality in Europe in 2015 and an overview of trends since 1990
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Bertuccio, P., Alicandro, G., Malvezzi, M., Carioli, G., Boffetta, P., Levi, F., La Vecchia, C., and Negri, E.
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- 2019
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11. Cancer mortality in the elderly in 11 countries worldwide, 1970–2015
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Carioli, G., Malvezzi, M., Bertuccio, P., Hashim, D., Waxman, S., Negri, E., Boffetta, P., and La Vecchia, C.
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- 2019
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12. European cancer mortality predictions for the year 2019 with focus on breast cancer
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Malvezzi, M., Carioli, G., Bertuccio, P., Boffetta, P., Levi, F., La Vecchia, C., and Negri, E.
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- 2019
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13. Cancer mortality and predictions for 2018 in selected Australasian countries and Russia
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Carioli, G., Malvezzi, M., Bertuccio, P., Levi, F., Boffetta, P., Negri, E., and La Vecchia, C.
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- 2019
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14. European cancer mortality predictions for the year 2018 with focus on colorectal cancer
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Malvezzi, M., Carioli, G., Bertuccio, P., Boffetta, P., Levi, F., La Vecchia, C., and Negri, E.
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- 2018
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15. European cancer mortality predictions for the year 2017, with focus on lung cancer
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Malvezzi, M., Carioli, G., Bertuccio, P., Boffetta, P., Levi, F., La Vecchia, C., and Negri, E.
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- 2017
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16. Post-diagnosis serum 25-hydroxyvitamin D concentrations in women treated for breast cancer participating in a lifestyle trial in Italy.
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Fassio, A., Porciello, G., Carioli, G., Palumbo, E., Vitale, S., Luongo, A., Montagnese, C., Prete, M., Grimaldi, M., Pica, R., Rotondo, E., Falzone, L., Calabrese, I., Minopoli, A., Grilli, B., Cuomo, M., Fiorillo, P.C., Evangelista, C., Cavalcanti, E., and De Laurentiis, M.
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- 2024
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17. Liver transplantation in patients with non-neoplastic portal vein thrombosis: 20 years of experience in a single center
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Pinelli, D, Camagni, S, Amaduzzi, A, Frosio, F, Fontanella, L, Carioli, G, Guizzetti, M, Zambelli, M, Giovanelli, M, Fagiuoli, S, Colledan, M, Pinelli D., Camagni S., Amaduzzi A., Frosio F., Fontanella L., Carioli G., Guizzetti M., Zambelli M. F., Giovanelli M., Fagiuoli S., Colledan M., Pinelli, D, Camagni, S, Amaduzzi, A, Frosio, F, Fontanella, L, Carioli, G, Guizzetti, M, Zambelli, M, Giovanelli, M, Fagiuoli, S, Colledan, M, Pinelli D., Camagni S., Amaduzzi A., Frosio F., Fontanella L., Carioli G., Guizzetti M., Zambelli M. F., Giovanelli M., Fagiuoli S., and Colledan M.
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Background: The Yerdel classification is widely used for describing the severity of portal vein thrombosis (PVT) in liver transplant (LT) candidates, but might not accurately predict transplant outcome. Methods: We retrospectively analyzed data regarding 97 adult patients with PVT who underwent LT, investigating whether the complexity of portal reconstruction could better correlate with transplant outcome than the site and extent of the thrombosis. Results: 79/97 (80%) patients underwent thrombectomy and anatomical anastomosis (TAA), 18/97 (20%) patients underwent non-anatomical physiological reconstructions (non-TAA). PVT Yerdel grade was 1–2 in 72/97 (74%) patients, and 3–4 in 25/97 (26%) patients. Univariate analysis revealed higher 30-day mortality, 90-day mortality, 1-year mortality, and a higher rate of severe early complications in the non-TAA group than in the TAA group (p =.018,.001,.014,.009, respectively). In the model adjusted for PVT Yerdel grade, non-TAA remained independently associated with higher 30-day, 90-day, and 1-year mortality (p =.021,.007, and.015, respectively). The portal vein re-thrombosis and overall patient and graft survival rates were similar. Discussion: In our experience, the complexity of portal reconstruction better correlated with transplant outcome than the Yerdel classification, which did not even appear to be a reliable predictor of the surgical complexity and technique.
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- 2022
18. Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study
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Rossini, A, Cassibba, S, Perticone, F, Benatti, S, Venturelli, S, Carioli, G, Ghirardi, A, Rizzi, M, Barbui, T, Trevisan, R, Ippolito, S, Rossini, Alessandro, Cassibba, Sara, Perticone, Francesca, Benatti, Simone Vasilij, Venturelli, Serena, Carioli, Greta, Ghirardi, Arianna, Rizzi, Marco, Barbui, Tiziano, Trevisan, Roberto, Ippolito, Silvia, Rossini, A, Cassibba, S, Perticone, F, Benatti, S, Venturelli, S, Carioli, G, Ghirardi, A, Rizzi, M, Barbui, T, Trevisan, R, Ippolito, S, Rossini, Alessandro, Cassibba, Sara, Perticone, Francesca, Benatti, Simone Vasilij, Venturelli, Serena, Carioli, Greta, Ghirardi, Arianna, Rizzi, Marco, Barbui, Tiziano, Trevisan, Roberto, and Ippolito, Silvia
- Abstract
Introduction: Thyroid dysfunctions associated with SARS-CoV-2 acute infection have been extensively described since the beginning of COVID-19 pandemics. Conversely, few data are available on the occurrence of thyroid autoimmunity after COVID-19 resolution. We assessed the prevalence of autoimmune thyroid disease (ATD) and thyroid dysfunctions in COVID-19 survivors three months after hospital admission. Design and methods: Single-center, prospective, observational, cohort study performed at ASST Papa Giovanni XXIII Hospital, Bergamo, Italy. 599 COVID-19 survivors were prospectively evaluated for thyroid function and autoimmunity thyroperoxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb). When a positive antibody concentration was detected, thyroid ultrasound was performed. Multiple logistic regression model was used to estimate the association between autoimmunity and demographic characteristics, respiratory support, and comorbidities. Autoimmunity results were compared to a cohort of 498 controls referred to our Institution for non-thyroid diseases before the pandemic onset. A sensitivity analysis comparing 330 COVID-19 patients with 330 age and sex-matched controls was performed. Results: Univariate and multivariate analysis found that female sex was positively associated (OR 2.01, SE 0.48, p = 0.003), and type 2 diabetes (T2DM) was negatively associated (OR 0.36, SE 0.16, p = 0.025) with thyroid autoimmunity; hospitalization, ICU admission, respiratory support, or COVID-19 treatment were not associated with thyroid autoimmunity (p > 0.05). TPOAb prevalence was greater in COVID-19 survivors than in controls: 15.7% vs 7.7%, p = 0.002. Ultrasonographic features of thyroiditis were present in 94.9% of the evaluated patients with positive antibodies. TSH was within the normal range in 95% of patients. Conclusions: Autoimmune thyroid disease prevalence in COVID-19 survivors was doubled as compared to age and sex-matched controls, suggesting a role of SARS-Co
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- 2023
19. European cancer mortality predictions for the year 2016 with focus on leukaemias
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Malvezzi, M., Carioli, G., Bertuccio, P., Rosso, T., Boffetta, P., Levi, F., La Vecchia, C., and Negri, E.
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- 2016
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20. Risk factors for neuroendocrine neoplasms: a systematic review and meta-analysis
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Leoncini, E., Carioli, G., La Vecchia, C., Boccia, S., and Rindi, G.
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- 2016
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21. COVID-19 impact on familial relationships and mental health in a representative sample of adults
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Vigezzi, GP, primary, Zeduri, M, additional, Carioli, G, additional, Lugo, A, additional, Amerio, A, additional, Gorini, G, additional, Pacifici, R, additional, Politi, P, additional, Gallus, S, additional, and Odone, A, additional
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- 2022
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22. One-year mortality in COVID-19 is associated with patients’ comorbidities rather than pneumonia severity
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Novelli, L, primary, Raimondi, F, additional, Carioli, G, additional, Carobbio, A, additional, Pappacena, S, additional, Malandrino, L, additional, Biza, R, additional, Trapasso, R, additional, Anelli, M, additional, Amoroso, M, additional, Allegri, C, additional, Imeri, G, additional, Conti, C, additional, Beretta, M, additional, Rizzi, M, additional, Lorini, F L, additional, Senni, M, additional, Rambaldi, A, additional, Barbui, T, additional, and Di Marco, F, additional
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- 2022
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23. Working Conditions and Health Among Italian Ageing Workers
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D'Errico, A., Ardito, C., Leombruni, R., Ricceri, F., Costa, G., Sacerdote, C., Odone, A., Amerio, A., Carioli, G., Fontana, D., Frascella, B., Gaetti, G., Gentile, L., Gianfredi, V., Stuckler, D., Vigezzi, G. P., Zengarini, N., D'Errico, A., Ardito, C., Leombruni, R., Ricceri, F., Costa, G., Sacerdote, C., Odone, A., Amerio, A., Carioli, G., Fontana, D., Frascella, B., Gaetti, G., Gentile, L., Gianfredi, V., Stuckler, D., Vigezzi, G. P., and Zengarini, N.
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Ageing ,Retirement ,Sociology and Political Science ,Arts and Humanities (miscellaneous) ,Health ,Developmental and Educational Psychology ,Working conditions ,General Social Sciences - Abstract
In many European countries requirements for retirement have been tightened, causing an increase in work participation of older workers, in spite their potentially poorer health may limit their work ability. This study aimed at assessing the diffusion of health problems and exposure to unfavorable working conditions among ageing workers in two Italian surveys, as well as comparing them with those observed in the same surveys conducted before the 2011 Italian pension reform tightening the normal retirement age. The 2013 National Health Survey (NHS) and Labour Force Survey (LFS) were employed to assess the prevalence of poor perceived health, health conditions and functional limitations, and of exposure to physical, psychosocial and organization factors at work, among 60–64 years workers. Poisson regression models were used to estimate Prevalence Ratios of health outcomes and unfavorable working conditions in the two surveys, compared to data from the 2005 (NHS) and 2007 (LFS) corresponding surveys, respectively. Among both men and women, approximately one quarter had at least one physical disorder or functional limitations and 15% poor mental health. Exposure to different ergonomic factors (15–30%) and working during unsocial hours (19%) were particularly diffused. A significant increase in the prevalence of functional limitations and of working at night or during unsocial hours was found in 2013, compared to corresponding data from 2005 and 2007, respectively. Our results indicate that exposure to ergonomic and organizational hazards should be reduced among ageing workers, to avoid decreased work ability, health damage or early exit from the labour market.
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- 2022
24. Global trends in oral and pharyngeal cancer incidence and mortality
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Bosetti, C, Carioli, G, Santucci, C, Bertuccio, P, Gallus, S, Garavello, W, Negri, E, La Vecchia, C, Bosetti C., Carioli G., Santucci C., Bertuccio P., Gallus S., Garavello W., Negri E., La Vecchia C., Bosetti, C, Carioli, G, Santucci, C, Bertuccio, P, Gallus, S, Garavello, W, Negri, E, La Vecchia, C, Bosetti C., Carioli G., Santucci C., Bertuccio P., Gallus S., Garavello W., Negri E., and La Vecchia C.
- Abstract
To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010–2015, and, for selected most populous countries, over the period 1970–2016. For 12 largest countries, we analyzed incidence derived from Cancer Incidence in Five Continents in 1960–2012 for all oral and pharyngeal cancers and by subsites. In 2015, male age-standardized (world population) death rates per 100,000 were 5.03 in the European Union (EU), 8.33 in the Russian Federation, 2.53 in the United States (USA), and 3.04 in Japan; corresponding rates in women were 1.23, 1.23, 0.82, and 0.76. Male mortality decreased over the last decades in several European countries, with earlier and sharper declines in southern Europe; conversely, mortality was still increasing in a few eastern European countries and the United Kingdom. Mortality in men also decreased in Argentina, Australia, and Hong Kong, while it leveled off over more recent calendar years in Brazil, Japan, Mexico, the Republic of Korea, as well as in Australia and the USA. Female mortality slightly rose in various European countries. Overall incidence trends in the largest countries were broadly consistent with mortality ones, but oropharyngeal cancer incidence rose in many countries. Changes in tobacco and alcohol exposure in men over the last decades likely explain the favorable trends in oral and pharyngeal cancer mortality and incidence observed in selected countries worldwide, while increased human papillomavirus infection is likely responsible for the rise in oropharyngeal cancer incidence.
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- 2020
25. Cancer mortality predictions for 2017 in Latin America
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Carioli, G., La Vecchia, C., Bertuccio, P., Rodriguez, T., Levi, F., Boffetta, P., Negri, E., and Malvezzi, M.
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- 2017
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26. Transition to retirement impact on health and lifestyle habits: analysis from a nationwide Italian cohort
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Vigezzi G. P., Gaetti G., Gianfredi V., Frascella B., Gentile L., d'Errico A., Stuckler D., Ricceri F., Costa G., Odone A., Amerio A., Ardito C., Carioli G., Fontana D., Leombruni R., Sacerdote C., Zengarini N., Vigezzi, G. P., Gaetti, G., Gianfredi, V., Frascella, B., Gentile, L., D'Errico, A., Stuckler, D., Ricceri, F., Costa, G., Odone, A., Amerio, A., Ardito, C., Carioli, G., Fontana, D., Leombruni, R., Sacerdote, C., and Zengarini, N.
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Adult ,medicine.medical_specialty ,Population ,Health Promotion ,Overweight ,smoking ,Habits ,Self-rated health ,Epidemiology ,medicine ,Humans ,education ,Life Style ,Aged ,Retirement ,education.field_of_study ,ageing ,retirement ,self-rated ,business.industry ,Physical activity ,Research ,Public health ,Ageing ,Cohort study ,Health behaviour ,Italy ,Middle Aged ,Public Health, Environmental and Occupational Health ,Cohort ,Propensity score matching ,medicine.symptom ,Public aspects of medicine ,RA1-1270 ,business ,Demography - Abstract
Background Retirement is a life-course transition likely to affect, through different mechanisms, behavioural risk factors’ patterns and, ultimately, health outcomes. We assessed the impact of transitioning to retirement on lifestyle habits and perceived health status in a nationwide cohort of Italian adults. Methods We analysed data from a large cohort of Italian adults aged 55–70, derived from linking six waves of the Participation, Labour, Unemployment Survey (PLUS), a national survey representative of the Italian workforce population, conducted between 2010 and 2018. We estimated relative-risk ratios (RRR) of transition to retirement and their corresponding 95% confidence intervals (CIs) for selected behavioural risk factors and health outcomes using multivariable logistic regression models. We used propensity score matching (PSM) to account for potential confounders. Results We included 5169 subjects in the study population, of which 1653 retired between 2010 and 2018 (exposed, 32%). Transition to retirement was associated with a 36% increased probability of practising sports (RRR 1.36, 95% CI 1.12–1.64). No statistically significant changes were reported for smoking habit (current smoker RRR: 1.18, 95% CI 0.94–1.46) and BMI (overweight/obese RRR: 0.96, 95% CI 0.81–1.15). Overall, retiring was associated with improved self-rated health status (RRR 1.26, 95% CI 1.02–1.58). Conclusion Individual data-linkage of multiple waves of the PLUS can offer great insight to inform healthy ageing policies in Italy and Europe. Transition to retirement has an independent effect on perceived health status, physical activity and selected behavioural risk factors. It should be identified as a target moment for preventive interventions, with particular reference to primary prevention so as to promote health and wellbeing in older ages.
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- 2021
27. After Action Reviews to assess COVID-19 hospital responses
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Sorbello, S, primary, Bossi, E, additional, Zandalasini, C, additional, Carioli, G, additional, Pleet, A, additional, Signorelli, C, additional, Ciceri, F, additional, Ambrosio, A, additional, and Odone, A, additional
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- 2021
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28. Mammographic breast density and characteristics of invasive breast cancer
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Pizzato, M., Carioli, G., Rosso, S., Zanetti, R., and La Vecchia, C.
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- 2021
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29. Risk factors for pancreas and lung neuroendocrine neoplasms: a case–control study
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Giraldi, Luca, Vecchioni, Alessia, Carioli, G., Bilotta, M., La Rosa, S., Imperatori, A., Volante, Mariangela, Brizzi, M. P., Inzani, Frediano, Petrone, Gianluigi, Schinzari, Giovanni, Bianchi, Antonio, Margaritora, Stefano, Alfieri, Sergio, La Vecchia, C., Boccia, Stefania, Rindi, Guido, Giraldi L., Vecchioni A., Volante M., Inzani F., Petrone G., Schinzari G. (ORCID:0000-0001-6105-7252), Bianchi A., Margaritora S. (ORCID:0000-0002-9796-760X), Alfieri S. (ORCID:0000-0002-0404-724X), Boccia S. (ORCID:0000-0002-1864-749X), Rindi G. (ORCID:0000-0003-2996-4404), Giraldi, Luca, Vecchioni, Alessia, Carioli, G., Bilotta, M., La Rosa, S., Imperatori, A., Volante, Mariangela, Brizzi, M. P., Inzani, Frediano, Petrone, Gianluigi, Schinzari, Giovanni, Bianchi, Antonio, Margaritora, Stefano, Alfieri, Sergio, La Vecchia, C., Boccia, Stefania, Rindi, Guido, Giraldi L., Vecchioni A., Volante M., Inzani F., Petrone G., Schinzari G. (ORCID:0000-0001-6105-7252), Bianchi A., Margaritora S. (ORCID:0000-0002-9796-760X), Alfieri S. (ORCID:0000-0002-0404-724X), Boccia S. (ORCID:0000-0002-1864-749X), and Rindi G. (ORCID:0000-0003-2996-4404)
- Abstract
Purpose: Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN. Methods: We conducted a case–control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured questionnaire included 84 queries on socio-demographic, behavioral, dietary and clinical information. Results: Increased risk was associated with history of cancer (“other tumor”, lung OR = 7.18; 95% CI: 2.55–20.20 and pancreas OR = 5.88; 95% CI: 2.43–14.22; “family history of tumor”, lung OR = 2.66; 95% CI: 1.53–4.64 and pancreas OR = 1.94; 95% CI: 1.19–3.17; “family history of lung tumor”, lung OR = 2.56; 95% CI: 1.05–6.24 and pancreas OR = 2.60; 95% CI: 1.13–5.95). Type 2 diabetes mellitus associated with an increased risk of pancreatic NEN (OR = 3.01; 95% CI: 1.15–7.89). Conclusions: Besides site-specific risk factors, there is a significant link between neuroendocrine neoplasia and cancer in general, pointing to a shared cancer predisposition.
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- 2021
30. Global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: Focus on low-risk areas
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Carioli, G, Negri, E, Kawakita, D, La Vecchia, C, Malvezzi, M., GARAVELLO, WERNER, G. Carioli, E. Negri, D. Kawakita, W. Garavello, C. La Vecchia, M. Malvezzi, Carioli, G, Negri, E, Kawakita, D, Garavello, W, La Vecchia, C, and Malvezzi, M
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Adult ,Male ,Cancer Research ,Time Factors ,Time Factor ,Adolescent ,Prognosi ,nasopharyngeal cancer ,Sex Factor ,Global Health ,World Health Organization ,tobacco ,Cohort Studies ,Young Adult ,Sex Factors ,Risk Factors ,Humans ,Age Factor ,Mortality ,Child ,Aged ,Nasopharyngeal Neoplasm ,alcohol ,Risk Factor ,Medicine (all) ,Age Factors ,Infant, Newborn ,Infant ,Nasopharyngeal Neoplasms ,Middle Aged ,Prognosis ,Survival Rate ,Oncology ,Child, Preschool ,Epstein Barr viru ,Carcinoma, Squamous Cell ,Female ,Cohort Studie ,diet ,Human - Abstract
Nasopharyngeal cancer (NPC) mortality shows great disparity between endemic high risk areas, where non-keratinizing carcinoma (NKC) histology is prevalent, and non-endemic low risk regions, where the keratinizing squamous cell carcinoma (KSCC) type is more frequent. We used the World Health Organization database to calculate NPC mortality trends from 1970 to 2014 in several countries worldwide. For the European Union (EU), the United States (US) and Japan, we also predicted trends to 2020. In 2012, the highest age-standardized (world standard) rates were in Hong Kong (4.51/100,000 men and 1.15/100,000 women), followed by selected Eastern European countries. The lowest rates were in Northern Europe and Latin America. EU rates were 0.27/100,000 men and 0.09/100,000 women, US rates were 0.20/100,000 men and 0.08/100,000 women and Japanese rates were 0.16/100,000 men and 0.04/100,000 women. NPC mortality trends were favourable for several countries. The decline was −15% in men and −5% in women between 2002 and 2012 in the EU, −12% in men and −9% in women in the US and about −30% in both sexes in Hong Kong and Japan. The favourable patterns in Europe and the United States are predicted to continue. Changes in salted fish and preserved food consumption account for the fall in NKC. Smoking and alcohol prevalence disparities between sexes and geographic areas may explain the different rates and trends observed for KSCC and partially for NKC. Dietary patterns, as well as improvement in management of the disease, may partly account for the observed trends, too.
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- 2016
31. Reply to the letter to the editor ‘European cancer mortality predictions for the year 2019 with focus on breast cancer, by Malvezzi M et al’ by Marsden and Hamoda, On behalf of the British Menopause Society Medical Advisory Council
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Malvezzi, M., primary, Carioli, G., additional, Bertuccio, P., additional, Boffetta, P., additional, Levi, F., additional, La Vecchia, C., additional, and Negri, E., additional
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- 2019
- Full Text
- View/download PDF
32. Relation between mortality trends of cardiovascular diseases and selected cancers in the European Union, in 1970–2017. Focus on cohort and period effects
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Malvezzi, M., primary, Carioli, G., additional, Bertuccio, P., additional, Negri, E., additional, and La Vecchia, C., additional
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- 2018
- Full Text
- View/download PDF
33. Management and Survival of Pleural Mesothelioma: A Record Linkage Study
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Carioli, G, Bonifazi, M, Rossi, M, Zambelli, A, Franchi, M, Zocchetti, C, Gasparini, S, Corrao, G, La Vecchia, C, Negri, E, Carioli, G, Bonifazi, M, Rossi, M, Zambelli, A, Franchi, M, Zocchetti, C, Gasparini, S, Corrao, G, La Vecchia, C, and Negri, E
- Abstract
Background: Pleural mesothelioma (PM) is a rare, highly lethal tumor. A definite consensus on its management has yet to be established. Objectives: To assess management, overall survival (OS), and their predictors in a cohort of patients from Lombardy, the largest Italian region (about 10 million inhabitants). Methods: Through a record linkage between Lombardy health care administrative databases, we identified patients diagnosed with PM in 2006â2011 without history of cancer, evaluating their management. OS from PM diagnosis was estimated using the Kaplan-Meier method. Predictors of OS and of treatment were assessed using Cox regression models with time-dependent covariates when appropriate. Results: Out of 1,326 patients, 754 (56.9%) received treatment for PM: 205 (15.5%) underwent surgery, and 696 (52.5%) used chemotherapy. Surgery was spread across several hospitals, and most patients diagnosed in nonspecialized centers (70%) underwent surgery in the same centers. Age at diagnosis was a strong inverse determinant of surgery. Determinants of receiving chemotherapy were younger age, a more recent first diagnosis, and first diagnosis in a specialized center. OS was 45.4% at 1 year, 24.8% at 2 years, and 9.6% at 5 years (median 11 months). OS decreased with age, and was higher for those who underwent surgery, but not for those treated with chemotherapy. Conclusions: Management of PM varied widely in clinical practice, and significant predictors of treatment were younger age and recent diagnosis, though a high proportion of patients were not treated. Patients were treated in various hospitals, indicating the importance of concentrating serious rare neoplasms in Comprehensive Cancer Centers (as recognized by the Italian Health Ministry)
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- 2018
34. Global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: Focus on low-risk areas
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Carioli, G, Negri, E, Kawakita, D, Garavello, W, La Vecchia, C, Malvezzi, M, Malvezzi, M., GARAVELLO, WERNER, Carioli, G, Negri, E, Kawakita, D, Garavello, W, La Vecchia, C, Malvezzi, M, Malvezzi, M., and GARAVELLO, WERNER
- Abstract
Nasopharyngeal cancer (NPC) mortality shows great disparity between endemic high risk areas, where non-keratinizing carcinoma (NKC) histology is prevalent, and non-endemic low risk regions, where the keratinizing squamous cell carcinoma (KSCC) type is more frequent. We used the World Health Organization database to calculate NPC mortality trends from 1970 to 2014 in several countries worldwide. For the European Union (EU), the United States (US) and Japan, we also predicted trends to 2020. In 2012, the highest age-standardized (world standard) rates were in Hong Kong (4.51/100,000 men and 1.15/100,000 women), followed by selected Eastern European countries. The lowest rates were in Northern Europe and Latin America. EU rates were 0.27/100,000 men and 0.09/100,000 women, US rates were 0.20/100,000 men and 0.08/100,000 women and Japanese rates were 0.16/100,000 men and 0.04/100,000 women. NPC mortality trends were favourable for several countries. The decline was −15% in men and −5% in women between 2002 and 2012 in the EU, −12% in men and −9% in women in the US and about −30% in both sexes in Hong Kong and Japan. The favourable patterns in Europe and the United States are predicted to continue. Changes in salted fish and preserved food consumption account for the fall in NKC. Smoking and alcohol prevalence disparities between sexes and geographic areas may explain the different rates and trends observed for KSCC and partially for NKC. Dietary patterns, as well as improvement in management of the disease, may partly account for the observed trends, too.
- Published
- 2017
35. Global trends and predictions in ovarian cancer mortality
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Malvezzi, M., primary, Carioli, G., additional, Rodriguez, T., additional, Negri, E., additional, and La Vecchia, C., additional
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- 2016
- Full Text
- View/download PDF
36. Trastuzumab for HER2+ metastatic breast cancer in clinical practice: Cardiotoxicity and overall survival
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Rossi, M, Carioli, G, Bonifazi, M, Zambelli, A, Franchi, M, Moja, L, Zambon, A, Corrao, G, La Vecchia, C, Zocchetti, C, Negri, E, Negri, E., FRANCHI, MATTEO, ZAMBON, ANTONELLA, CORRAO, GIOVANNI, Rossi, M, Carioli, G, Bonifazi, M, Zambelli, A, Franchi, M, Moja, L, Zambon, A, Corrao, G, La Vecchia, C, Zocchetti, C, Negri, E, Negri, E., FRANCHI, MATTEO, ZAMBON, ANTONELLA, and CORRAO, GIOVANNI
- Abstract
The evidence on efficacy and safety of trastuzumab in metastatic breast cancers (MBC) mainly derives from randomized clinical trials. We assessed short- and long-term overall survival (OS) and cardiotoxicity in a large cohort of women with MBC treated with trastuzumab in clinical settings. Using healthcare administrative data of Lombardy (10 millions inhabitants), we identified a cohort of women receiving trastuzumab for MBC between 2006 and 2009. The cumulative risk of severe cardiac events and the OS from the first trastuzumab administration were estimated using the Kaplan-Meier method. Their predictors were assessed using Cox regression models. We found 681 trastuzumab MBC users. Thirty two (4.7%) women experienced severe cardiac adverse events. The cumulative risk increased sharply, reaching a value of 2.4% and 4.3% during the first and second year; thereafter it increased of about 1% per year. Age was a strong predictor of cardiotoxicity. The OS was 81.8%, 64.0%, 50.2%, 41.1% and 37.2% at 1, 2, 3, 4 and 5 years, respectively. Independent predictors of worse OS were: age, brain liver or lung metastasis compared to other metastasis, use of taxanes and other chemotherapies, a cardiac adverse event after trastuzumab use, and a higher time between metastasis and BC diagnoses. The incidence of cardiotoxicity among women treated with trastuzumab for HER2-positive MBC appeared higher than that reported in RCTs, particularly in elder patients. In spite of this, median survival, was, if anything, better.
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- 2016
37. Clinical use, safety and effectiveness of novel high cost anticancer therapies after marketing approval: A record linkage study
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Negri, E, Rossi, M, Bonifazi, M, Franchi, M, Carioli, G, Zocchetti, C, Corrao, G, La Vecchia, C, La Vecchia, C., FRANCHI, MATTEO, CORRAO, GIOVANNI, Negri, E, Rossi, M, Bonifazi, M, Franchi, M, Carioli, G, Zocchetti, C, Corrao, G, La Vecchia, C, La Vecchia, C., FRANCHI, MATTEO, and CORRAO, GIOVANNI
- Abstract
Background: major clinical outcomes of anticancer drugs may differ between clinical trials and clinical practice. Administrative databases provide long-term information on safety and effectiveness of these drugs in large unselected populations and in selected subgroups of patients. In addition, these data provide complementary information on topics where evidence from randomized clinical trials is unavailable. Methods: this project will investigate 17 new targeted high cost drugs in Lombardy oncology practice between 2006 and 2010 using data from electronic healthcare databases. Specific objectives are: 1) to estimate the incidence of serious adverse events in clinical practice and their predictors; 2) to estimate survival and progression free survival and their predictors; 3) to compare major clinical outcomes according to different regimen of therapy. We will build a database by record linkage of several regional health service sources: the File F registry (in which the administration of the 17 drugs is recorded), the Regional hospital discharge forms (SDO) database, the drug prescription database, the outpatients' services database, and the Registry Office database. Subjects resident in Lombardy who received at least one prescription of these drugs from 2006 to 2010 will be considered. Complications warranting hospitalization will be derived from the patients' SDO s after the first drug administration. Vital status will be obtained from the Registry Office database. RESULTS: we will provide estimates of the incidence of serious adverse events of novel anticancer therapies, and of overall and disease free survival in clinical practice, overall and in selected subgroups. CONCLUSIONS: these data will contribute to a better effectiveness evaluation, particularly in patients under-represented in clinical trials.
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- 2013
38. Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study
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Alessandro Rossini, Sara Cassibba, Francesca Perticone, Simone Vasilij Benatti, Serena Venturelli, Greta Carioli, Arianna Ghirardi, Marco Rizzi, Tiziano Barbui, Roberto Trevisan, Silvia Ippolito, Rossini, A, Cassibba, S, Perticone, F, Benatti, S, Venturelli, S, Carioli, G, Ghirardi, A, Rizzi, M, Barbui, T, Trevisan, R, and Ippolito, S
- Subjects
thyroid peroxidase (TPO) antibodie ,SARS-CoV-2 ,thyroid dysfunction ,Endocrinology, Diabetes and Metabolism ,thyroid autoimmunity ,COVID-19 ,autoimmune disease ,autoimmune thyroid disease ,thyroiditi - Abstract
IntroductionThyroid dysfunctions associated with SARS-CoV-2 acute infection have been extensively described since the beginning of COVID-19 pandemics. Conversely, few data are available on the occurrence of thyroid autoimmunity after COVID-19 resolution. We assessed the prevalence of autoimmune thyroid disease (ATD) and thyroid dysfunctions in COVID-19 survivors three months after hospital admission.Design and methodsSingle-center, prospective, observational, cohort study performed at ASST Papa Giovanni XXIII Hospital, Bergamo, Italy. 599 COVID-19 survivors were prospectively evaluated for thyroid function and autoimmunity thyroperoxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb). When a positive antibody concentration was detected, thyroid ultrasound was performed. Multiple logistic regression model was used to estimate the association between autoimmunity and demographic characteristics, respiratory support, and comorbidities. Autoimmunity results were compared to a cohort of 498 controls referred to our Institution for non-thyroid diseases before the pandemic onset. A sensitivity analysis comparing 330 COVID-19 patients with 330 age and sex-matched controls was performed.ResultsUnivariate and multivariate analysis found that female sex was positively associated (OR 2.01, SE 0.48, p = 0.003), and type 2 diabetes (T2DM) was negatively associated (OR 0.36, SE 0.16, p = 0.025) with thyroid autoimmunity; hospitalization, ICU admission, respiratory support, or COVID-19 treatment were not associated with thyroid autoimmunity (p > 0.05). TPOAb prevalence was greater in COVID-19 survivors than in controls: 15.7% vs 7.7%, p = 0.002. Ultrasonographic features of thyroiditis were present in 94.9% of the evaluated patients with positive antibodies. TSH was within the normal range in 95% of patients.ConclusionsAutoimmune thyroid disease prevalence in COVID-19 survivors was doubled as compared to age and sex-matched controls, suggesting a role of SARS-CoV-2 in eliciting thyroid autoimmunity.
- Published
- 2023
39. Liver transplantation in patients with non‐neoplastic portal vein thrombosis: 20 years of experience in a single center
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M Guizzetti, M. Giovanelli, Annalisa Amaduzzi, Domenico Pinelli, Laura Fontanella, Michele Colledan, Stefania Camagni, Fabio Frosio, M. Zambelli, Stefano Fagiuoli, Greta Carioli, Pinelli, D, Camagni, S, Amaduzzi, A, Frosio, F, Fontanella, L, Carioli, G, Guizzetti, M, Zambelli, M, Giovanelli, M, Fagiuoli, S, and Colledan, M
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Adult ,Liver Cirrhosis ,medicine.medical_specialty ,Non neoplastic ,medicine.medical_treatment ,portal reconstruction ,Liver transplantation ,Single Center ,medicine ,Humans ,In patient ,portal vein thrombosi ,Retrospective Studies ,Venous Thrombosis ,Transplantation ,Univariate analysis ,liver transplantation ,Portal Vein ,business.industry ,transplant outcome ,medicine.disease ,Thrombosis ,Surgery ,Portal vein thrombosis ,Anatomical anastomosis ,Treatment Outcome ,business - Abstract
BACKGROUND The Yerdel classification is widely used for describing the severity of portal vein thrombosis (PVT) in liver transplant (LT) candidates, but might not accurately predict transplant outcome. METHODS We retrospectively analyzed data regarding 97 adult patients with PVT who underwent LT, investigating whether the complexity of portal reconstruction could better correlate with transplant outcome than the site and extent of the thrombosis. RESULTS 79/97 (80%) patients underwent thrombectomy and anatomical anastomosis (TAA), 18/97 (20%) patients underwent non-anatomical physiological reconstructions (non-TAA). PVT Yerdel grade was 1-2 in 72/97 (74%) patients, and 3-4 in 25/97 (26%) patients. Univariate analysis revealed higher 30-day mortality, 90-day mortality, 1-year mortality, and a higher rate of severe early complications in the non-TAA group than in the TAA group (p = .018, .001, .014, .009, respectively). In the model adjusted for PVT Yerdel grade, non-TAA remained independently associated with higher 30-day, 90-day, and 1-year mortality (p = .021, .007, and .015, respectively). The portal vein re-thrombosis and overall patient and graft survival rates were similar. DISCUSSION In our experience, the complexity of portal reconstruction better correlated with transplant outcome than the Yerdel classification, which did not even appear to be a reliable predictor of the surgical complexity and technique.
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- 2021
40. European cancer mortality predictions for the year 2019 with focus on breast cancer
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C. La Vecchia, Greta Carioli, Paolo Boffetta, Matteo Malvezzi, Paola Bertuccio, Eva Negri, Fabio Levi, Malvezzi M., Carioli G., Bertuccio P., Boffetta P., Levi F., La Vecchia C., and Negri E.
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Population ageing ,medicine.medical_treatment ,mortality rate ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Epidemiology of cancer ,medicine ,cancer ,media_common.cataloged_instance ,European union ,media_common ,Cancer Death Rate ,business.industry ,Mortality rate ,prediction models ,Cancer ,Hormone replacement therapy (menopause) ,Hematology ,medicine.disease ,Europe ,030104 developmental biology ,030220 oncology & carcinogenesis ,business ,Demography - Abstract
Background To overcome the lag with which cancer statistics become available, we predicted numbers of deaths and rates from all cancers and selected cancer sites for 2019 in the European Union (EU). Materials and methods We retrieved cancer death certifications and population data from the World Health Organization and Eurostat databases for 1970–2014. We obtained estimates for 2019 with a linear regression on number of deaths over the most recent trend period identified by a logarithmic Poisson joinpoint regression model. We calculated the number of avoided deaths over the period 1989–2019. Results We estimated about 1 410 000 cancer deaths in the EU for 2019, corresponding to age-standardized rates of 130.9/100 000 men (−5.9% since 2014) and 82.9 women (−3.6%). Lung cancer trends in women are predicted to increase 4.4% between 2014 and 2019, reaching a rate of 14.8. The projected rate for breast cancer was 13.4. Favourable trends for major neoplasms are predicted to continue, except for pancreatic cancer. Trends in breast cancer mortality were favourable in all six countries considered, except Poland. The falls were largest in women 50–69 (−16.4%), i.e. the age group covered by screening, but also seen at age 20–49 (−13.8%), while more modest at age 70–79 (−6.1%). As compared to the peak rate in 1988, over 5 million cancer deaths have been avoided in the EU over the 1989–2019 period. Of these, 440 000 were breast cancer deaths. Conclusion Between 2014 and 2019, cancer mortality will continue to fall in both sexes. Breast cancer rates will fall steadily, with about 35% decline in rates over the last three decades. This is likely due to reduced hormone replacement therapy use, improvements in screening, early diagnosis and treatment. Due to population ageing, however, the number of breast cancer deaths is not declining.
- Published
- 2019
41. Relation between mortality trends of cardiovascular diseases and selected cancers in the European Union, in 1970–2017. Focus on cohort and period effects
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Matteo Malvezzi, C. La Vecchia, Paola Bertuccio, Greta Carioli, Eva Negri, Malvezzi, M., Carioli, G., Bertuccio, P., Negri, E., and La Vecchia, C.
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Adult ,Male ,Cancer Research ,Stomach cancer ,Population ,History, 21st Century ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Cohort effect ,Neoplasms ,Humans ,Medicine ,media_common.cataloged_instance ,030212 general & internal medicine ,Mortality ,European union ,Cerebrovascular disease ,education ,Lung cancer ,media_common ,education.field_of_study ,business.industry ,Mortality rate ,Death rate ,Cancer ,History, 20th Century ,Middle Aged ,medicine.disease ,Colorectal cancer ,Europe ,Coronary heart disease ,Oncology ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Cohort ,Neoplasm ,Female ,business ,Demography - Abstract
Aim To characterise mortality trends from major non-communicable diseases in the European Union (EU) analysing data from the World Health Organization (WHO) Mortality Database. Methods We obtained EU population and death certification data for major non-communicable diseases, i.e. seven cancer sites (stomach, intestine, pancreas, lung, breast, prostate and haematopoietic), total cancers, coronary heart diseases (CHDs) and cerebrovascular diseases (CVDs) from the WHO Mortality Database over the 1970 and 2012 period. We computed age-standardised rates (world standard population) and applied joinpoint regression models to identify temporal trends and age period cohort (APC) models to disentangle the effects of age, period of death and cohort of birth on mortality. Results In 2012, 2.4 million deaths were recorded in the EU (1.3 million from cancers and 1.1 million from CHD and CVD combined). Over the last decade, mortality from cancer fell by 14% in men and 8% in women, resulting in age-standardised rates of 144 and 88/100,000 persons, respectively, in 2012. The only exceptions to the general downward trends were pancreatic cancer and female lung cancer. Both cardiovascular diseases mortality fell over 35% in both sexes with rates of 60 and 28/100,000 for CHD, and of 30 and 23/100,000 for CVD, in men and women, respectively, in 2012. Conclusions Overall trends in mortality rates from non-communicable diseases in the EU were favourable, and the joinpoint and APC models indicated these trends are likely to continue in the near future. Lack of progress in tobacco-related mortality in women underlines the importance of female-specific anti-tobacco policies.
- Published
- 2018
42. Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium
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Domenico Palli, Manoli García de la Hera, Shoichiro Tsugane, Francesca Bravi, Nuno Lunet, Pagona Lagiou, Jinfu Hu, Stefania Boccia, Monica Ferraroni, Lizbeth López-Carrillo, Areti Lagiou, Vicente Martín, Robert C. Kurtz, Mary H. Ward, Georgia Martimianaki, Eva Negri, Raúl U. Hernández-Ramírez, Kenneth C. Johnson, Anna Karakatsani, Carlo La Vecchia, M Costanza Camargo, Paolo Boffetta, Maria Paula Curado, Paola Bertuccio, Reza Malekzadeh, Zuo-Feng Zhang, Charles S. Rabkin, Akihisa Hidaka, Dmitry Maximovitch, Linda M. Liao, David Zaridze, Jesús Vioque, Rossella Bonzi, Greta Carioli, Gianfranco Alicandro, Nuria Aragonés, Rashmi Sinha, Antonia Trichopoulou, Samantha Morais, Gerson Shigueaki Hamada, Claudio Pelucchi, Martimianaki G., Bertuccio P., Alicandro G., Pelucchi C., Bravi F., Carioli G., Bonzi R., Rabkin C.S., Liao L.M., Sinha R., Johnson K., Hu J., Palli D., Ferraroni M., Lunet N., Morais S., Tsugane S., Hidaka A., Hamada G.S., Lopez-Carrillo L., Hernandez-Ramirez R.U., Zaridze D., Maximovitch D., Aragones N., Martin V., Ward M.H., Vioque J., Garcia De La Hera M., Zhang Z.-F., Kurtz R.C., Lagiou P., Lagiou A., Trichopoulou A., Karakatsani A., Malekzadeh R., Camargo M.C., Curado M.P., Boccia S., Boffetta P., Negri E., and La Vecchia C.
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Cancer Research ,medicine.medical_specialty ,Epidemiology ,case-control study ,Oncology and Carcinogenesis ,coffee ,Coffee consumption ,Article ,Stomach Neoplasms ,Risk Factors ,Clinical Research ,Internal medicine ,Coffee intake ,Odds Ratio ,medicine ,Humans ,Oncology & Carcinogenesis ,Stomach cancer ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Cancer ,coffee consumption ,business.industry ,gastric cancer ,Public Health, Environmental and Occupational Health ,cardia cancer ,Odds ratio ,medicine.disease ,Confidence interval ,Observational Studies as Topic ,Logistic Models ,Pooled analysis ,Oncology ,Public Health and Health Services ,pooled analysis ,business ,Random intercept - Abstract
Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. Results Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. Conclusions These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.
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- 2021
43. Childhood cancer mortality trends in the Americas and Australasia: An update to 2017
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Carlo La Vecchia, Claudia Santucci, Paola Bertuccio, Matteo Malvezzi, Karina Braga Ribeiro, Paolo Boffetta, Fabio Levi, Eva Negri, Greta Carioli, Gianfranco Alicandro, Malvezzi M., Santucci C., Alicandro G., Carioli G., Boffetta P., Ribeiro K.B., Levi F., La Vecchia C., Negri E., and Bertuccio P.
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Male ,trends ,Cancer Research ,Joinpoint regression ,Latin Americans ,Asia ,Adolescent ,Epidemiology ,Childhood cancer ,Oceania ,America ,World Health Organization ,World health ,Discipline ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Humans ,Medicine ,cancer ,030212 general & internal medicine ,Child ,Mortality trends ,childhood ,Australasia ,business.industry ,Mortality rate ,Infant, Newborn ,Infant ,Original Articles ,mortality ,Latin America ,Cns neoplasms ,Oncology ,Mortality data ,Child, Preschool ,030220 oncology & carcinogenesis ,Original Article ,Female ,Americas ,business ,Demography - Abstract
Background Marked reductions in childhood cancer mortality occurred over the last decades in high‐income countries and, to a lesser degree, in middle‐income countries. This study aimed to monitor mortality trends in the Americas and Australasia, focusing on areas showing unsatisfactory trends. Methods Age‐standardized mortality rates per 100,000 children (aged 0‐14 years) from 1990 to 2017 (or the last available calendar year) were computed for all neoplasms and 8 leading childhood cancers in countries from the Americas and Australasia, using data from the World Health Organization database. A joinpoint regression was used to identify changes in slope of mortality trends for all neoplasms, leukemia, and neoplasms of the central nervous system (CNS) for major countries. Results Over the last decades, childhood cancer mortality continued to decrease by approximately 2% to 3% per year in Australasian countries (ie, Japan, Korea, and Australia), by approximately 1.5% to 2% in North America and Chile, and 1% in Argentina. Other Latin American countries did not show any substantial decrease. Leukemia mortality declined in most countries, whereas less favorable trends were registered for CNS neoplasms, particularly in Latin America. Around 2016, death rates from all neoplasms were 4 to 6 per 100,000 boys and 3 to 4 per 100,000 girls in Latin America, and 2 to 3 per 100,000 boys and approximately 2 per 100,000 girls in North America and Australasia. Conclusions Childhood cancer mortality trends declined steadily in North America and Australasia, whereas they were less favorable in most Latin American countries. Priority must be given to closing the gap by providing high‐quality care for all children with cancer worldwide. Lay Summary Advances in childhood cancer management have substantially improved the burden of these neoplasms over the past 40 years, particularly in high‐income countries.This study aimed to monitor recent trends in America and Australasia using mortality data from the World Health Organization.Trends in childhood cancer mortality continued to decline in high‐income countries by approximately 2% to 3% per year in Japan, Korea, and Australia, and 1% to 2% in North America.Only a few Latin American countries showed favorable trends, including Argentina, Chile, and Mexico, whereas other countries with limited resources still lagged behind., Childhood cancer mortality trends continued to be favorable in high‐income countries with declines by 1% to 3% per year, whereas less favorable trends emerged in most Latin American countries, with a few exceptions (ie, Argentina, Chile, and more recently, Mexico). Priority must be given to initiatives to close the gap by providing high‐quality care for all children with cancer worldwide.
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- 2021
44. After Action Reviews of COVID-19 response: Case study of a large tertiary care hospital in Italy
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Eleonora Bossi, Carlo Signorelli, Alberto Ambrosio, Alberto Zangrillo, Fabio Ciceri, Greta Carioli, Camilla Zandalasini, Anna Odone, Sebastiano Sorbello, Sorbello, S, Bossi, E, Zandalasini, C, Carioli, G, Signorelli, C, Ciceri, F, Ambrosio, A, Zangrillo, A, and Odone, A
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strategic reorganization ,medicine.medical_specialty ,after action review ,SARS‐CoV‐2 ,Tertiary Care Centers ,03 medical and health sciences ,COVID-19 Testing ,Multidisciplinary approach ,COVID‐19 ,Health care ,medicine ,Humans ,hospital management ,business.industry ,SARS-CoV-2 ,030503 health policy & services ,Health Policy ,Public health ,Corporate governance ,Staff management ,COVID-19 ,medicine.disease ,Communications management ,Action (philosophy) ,Italy ,Preparedness ,Utilization Review ,Medical emergency ,0305 other medical science ,Psychology ,business ,Research Article - Abstract
Background After‐Action Reviews (AARs) are management tools used to evaluate the response to public health emergencies at the national and subnational level. Aim of this study is to apply available AAR models to assess and critically appraise COVID‐19 response of San Raffaele Scientific Institute, a large university hospital in Milan, Italy. Methods We designed an AAR based on the key‐informant interview format, following the methodology proposed by the 2019 World Health Organization Guidance for AAR. After systematic assessment of the hospital reorganization, we conducted 36 semi‐structured interviews to professionals with executive, clinical, technical and administrative roles. We designed an ad‐hoc questionnaire exploring four areas: (i) staff management; (ii) logistics and supplies; (iii) COVID‐19 diagnosis and clinical management; (iv) communication. Results Overall, the hospital response was evaluated as effective and sufficiently prompt. Participants stressed the relevance of: (i) strong governance and coordination; (ii) readiness and availability of healthcare personnel; (iii) definition of a model of care based on a multidisciplinary approach. Challenges were reported for communication management and staff training. Conclusions This study is one of the first applications of the AAR to the COVID‐19 response in hospital settings, which can be successfully adapted or scaled up to other settings in order to implement preparedness strategies for future public health emergencies.
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- 2021
45. European cancer mortality predictions for the year 2021 with focus on pancreatic and female lung cancer
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Matteo Malvezzi, C. La Vecchia, Paola Bertuccio, Fabio Levi, Paolo Boffetta, Eva Negri, Greta Carioli, G. Carioli, M. Malvezzi, P. Bertuccio, P. Boffetta, F. Levi, C. La Vecchia, E. Negri, Carioli G., Malvezzi M., Bertuccio P., Boffetta P., Levi F., La Vecchia C., and Negri E.
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0301 basic medicine ,Male ,Lung Neoplasms ,pancreatic cancer ,Breast Neoplasms ,mortality rate ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Pancreatic cancer ,Neoplasms ,medicine ,Pancrea ,media_common.cataloged_instance ,Humans ,cancer ,European Union ,European union ,Mortality ,Lung cancer ,Pancreas ,media_common ,Aged ,Leukemia ,business.industry ,Mortality rate ,Tobacco control ,Cancer ,prediction models ,Hematology ,medicine.disease ,prediction model ,Lung Neoplasm ,Europe ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Female ,Brexit ,business ,Breast Neoplasm ,Human ,Demography - Abstract
Background We predicted cancer mortality statistics for 2021 for the European Union (EU) and its five most populous countries plus the UK. We also focused on pancreatic cancer and female lung cancer. Materials and methods We obtained cancer death certifications and population data from the World Health Organization and Eurostat databases for 1970-2015. We predicted numbers of deaths and age-standardised (world population) rates for 2021 for total cancers and 10 major cancer sites, using a joinpoint regression model. We calculated the number of avoided deaths over the period 1989-2021. Results We predicted 1 267 000 cancer deaths for 2021 in the EU, corresponding to age-standardised rates of 130.4/100 000 men (−6.6% since 2015) and 81.0/100 000 for women (−4.5%). We estimated further falls in male lung cancer rates, but still trending upward in women by +6.5%, reaching 14.5/100 000 in 2021. The breast cancer predicted rate in the EU was 13.3/100 000 (−7.8%). The rates for stomach and leukaemias in both sexes and for bladder in males are predicted to fall by >10%; trends for other cancer sites were also favourable, except for the pancreas, which showed stable patterns in both sexes, with predicted rates of 8.1/100 000 in men and 5.6/100 000 in women. Rates for pancreatic cancer in EU men aged 25-49 and 50-64 years declined, respectively, by 10% and 1.8%, while for those aged 65+ years increased by 1.3%. Rates fell for young women only (−3.4%). Over 1989-2021, about 5 million cancer deaths were avoided in the EU27 compared with peak rates in 1988. Conclusion Overall cancer mortality continues to fall in both sexes. However, specific focus is needed on pancreatic cancer, which shows a sizeable decline for young men only. Tobacco control remains a priority for the prevention of pancreatic and other tobacco-related cancers, which account for one-third of the total EU cancer deaths, especially in women, who showed less favourable trends.
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- 2021
46. Cohort analysis of epithelial cancer mortality male-to-female sex ratios in the European Union, USA, and Japan
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Paola Bertuccio, Paolo Boffetta, Greta Carioli, Carlo La Vecchia, Matteo Malvezzi, Eva Negri, Fabio Levi, Carioli G., Bertuccio P., Levi F., Boffetta P., Negri E., La Vecchia C., and Malvezzi M.
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Male ,Health, Toxicology and Mutagenesis ,lcsh:Medicine ,Overweight ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Neoplasms ,medicine ,media_common.cataloged_instance ,Humans ,030212 general & internal medicine ,European Union ,European union ,Age period cohort ,Mortality ,Thyroid cancer ,Epithelial cancer ,media_common ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,Cancer ,sex ratios ,medicine.disease ,Obesity ,United States ,Europe ,030220 oncology & carcinogenesis ,Cohort ,Female ,medicine.symptom ,Trends ,business ,Sex ratio ,Demography ,Cohort study - Abstract
Objective: To illustrate trends in sex ratios in epithelial cancer mortality in the EU, USA, and Japan, with a focus on age-specific and cohort patterns. Methods: We obtained certified deaths and resident populations from the World Health Organisation for the period of 1970&ndash, 2014 for the USA, Japan, and the EU for 12 epithelial cancer sites. From these, we calculated both the age-specific and age-standardised male-to-female mortality sex ratios. We applied an age-period-cohort model to the sex ratios in order to disentangle the effects of age, period of death, and birth cohort. Results: Age-standardised mortality sex ratios were found to be unfavourable to males, apart from thyroid cancer. The highest standardised rates were in laryngeal cancer: 7·, 7 in the 1970s in the USA, 17·, 4 in the 1980s in the EU, and 16·, 8 in the 2000s in Japan. Cohort patterns likely to be due to excess smoking (1890 cohort) and drinking (1940 cohort) in men were identified in the USA, and were present but less defined in the EU and Japan for the oral cavity, oesophagus, liver, pancreas, larynx, lung, bladder, and kidney. Conclusion: Mortality sex ratio patterns are partly explained by the differences in exposure to known and avoidable risk factors. These are mostly tobacco, alcohol, and obesity/overweight, as well as other lifestyle-related factors.
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- 2020
47. Global trends in oral and pharyngeal cancer incidence and mortality
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Werner Garavello, Claudia Santucci, Paola Bertuccio, Eva Negri, Greta Carioli, Carlo La Vecchia, Silvano Gallus, Cristina Bosetti, C. Bosetti, G. Carioli, C. Santucci, P. Bertuccio, S. Gallu, W. Garavello, E. Negri, C. La Vecchia, Bosetti, C, Carioli, G, Santucci, C, Bertuccio, P, Gallus, S, Garavello, W, Negri, E, and La Vecchia, C
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trends ,Adult ,Male ,Cancer Research ,Argentina ,oral and pharyngeal cancer ,Global Health ,Russia ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Pharyngeal cancer ,Republic of Korea ,media_common.cataloged_instance ,Humans ,age-standardized rate ,European union ,Mexico ,media_common ,Incidence (epidemiology) ,Mortality rate ,Incidence ,Australia ,Pharyngeal Neoplasms ,World population ,Middle Aged ,mortality ,United Kingdom ,United States ,Eastern european ,Europe ,Survival Rate ,Geography ,Death certification ,Oncology ,Cancer incidence ,030220 oncology & carcinogenesis ,Hong Kong ,Female ,Mouth Neoplasms ,Brazil ,Demography - Abstract
To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010–2015, and, for selected most populous countries, over the period 1970–2016. For 12 largest countries, we analyzed incidence derived from Cancer Incidence in Five Continents in 1960–2012 for all oral and pharyngeal cancers and by subsites. In 2015, male age-standardized (world population) death rates per 100,000 were 5.03 in the European Union (EU), 8.33 in the Russian Federation, 2.53 in the United States (USA), and 3.04 in Japan; corresponding rates in women were 1.23, 1.23, 0.82, and 0.76. Male mortality decreased over the last decades in several European countries, with earlier and sharper declines in southern Europe; conversely, mortality was still increasing in a few eastern European countries and the United Kingdom. Mortality in men also decreased in Argentina, Australia, and Hong Kong, while it leveled off over more recent calendar years in Brazil, Japan, Mexico, the Republic of Korea, as well as in Australia and the USA. Female mortality slightly rose in various European countries. Overall incidence trends in the largest countries were broadly consistent with mortality ones, but oropharyngeal cancer incidence rose in many countries. Changes in tobacco and alcohol exposure in men over the last decades likely explain the favorable trends in oral and pharyngeal cancer mortality and incidence observed in selected countries worldwide, while increased human papillomavirus infection is likely responsible for the rise in oropharyngeal cancer incidence.
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- 2019
48. European cancer mortality predictions for the year 2018 with focus on colorectal cancer
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C. La Vecchia, Paola Bertuccio, Paolo Boffetta, Fabio Levi, Matteo Malvezzi, Eva Negri, Greta Carioli, Malvezzi, M., Carioli, G., Bertuccio, P., Boffetta, P., Levi, F., Vecchia, Carlo La, and Negri, E.
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Male ,0301 basic medicine ,Colorectal cancer ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Prediction model ,Neoplasms ,Humans ,Medicine ,media_common.cataloged_instance ,European union ,Lung cancer ,Cancer ,media_common ,Cancer Death Rate ,Bladder cancer ,business.industry ,Mortality rate ,Hematology ,medicine.disease ,Europe ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Female ,Colorectal Neoplasms ,business ,Demography - Abstract
Background We projected cancer mortality statistics for 2018 for the European Union (EU) and its six more populous countries, using the most recent available data. We focused on colorectal cancer. Materials and methods We obtained cancer death certification data from stomach, colorectum, pancreas, lung, breast, uterus, ovary, prostate, bladder, leukaemia, and total cancers from the World Health Organisation database and projected population data from Eurostat. We derived figures for France, Germany, Italy, Poland, Spain, the UK, and the EU in 1970–2012. We predicted death numbers by age group and age-standardized (world population) rates for 2018 through joinpoint regression models. Results EU total cancer mortality rates are predicted to decline by 10.3% in men between 2012 and 2018, reaching a predicted rate of 128.9/100 000, and by 5.0% in women with a rate of 83.6. The predicted total number of cancer deaths is 1 382 000 when compared with 1 333 362 in 2012 (+3.6%). We confirmed a further fall in male lung cancer, but an unfavourable trend in females, with a rate of 14.7/100 000 for 2018 (13.9 in 2012, +5.8%) and 94 500 expected deaths, higher than the rate of 13.7 and 92 700 deaths from breast cancer. Colorectal cancer predicted rates are 15.8/100 000 men (−6.7%) and 9.2 in women (−7.5%); declines are expected in all age groups. Pancreatic cancer is stable in men, but in women it rose +2.8% since 2012. Ovarian, uterine and bladder cancer rates are predicted to decline further. In 2018 alone, about 392 300 cancer deaths were avoided compared with peak rates in the late 1980s. Conclusion We predicted continuing falls in mortality rates from major cancer sites in the EU and its major countries to 2018. Exceptions are pancreatic cancer and lung cancer in women. Improved treatment and—above age 50 years—organized screening may account for recent favourable colorectal cancer trends.
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- 2018
49. Reply to: 'Global trends in mortality from intrahepatic and extrahepatic cholangiocarcinoma'
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Paola Bertuccio, Dana Hashim, Matteo Malvezzi, Carlo La Vecchia, Greta Carioli, Hashem B. El-Serag, Paolo Boffetta, Eva Negri, Bertuccio P., Malvezzi M., Carioli G., Hashim D., Boffetta P., El-Serag H.B., La Vecchia C., and Negri E.
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Extrahepatic Cholangiocarcinoma ,Cholangiocarcinoma ,medicine.medical_specialty ,Bile Ducts, Intrahepatic ,Hepatology ,Bile Duct Neoplasms ,business.industry ,Internal medicine ,medicine ,Humans ,business ,Gastroenterology - Published
- 2019
50. Cancer mortality and predictions for 2018 in selected Australasian countries and Russia
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Paola Bertuccio, C. La Vecchia, Fabio Levi, Paolo Boffetta, Greta Carioli, Eva Negri, Matteo Malvezzi, and Carioli, G. and Malvezzi, M. and Bertuccio, P. and Levi, F. and Boffetta, P. and Negri, E. and La Vecchia, C.
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0301 basic medicine ,Male ,Time Factors ,Russia ,0302 clinical medicine ,Neoplasms ,Epidemiology ,Young adult ,Child ,media_common ,Aged, 80 and over ,education.field_of_study ,Incidence (epidemiology) ,Incidence ,Age Factors ,Hematology ,Middle Aged ,Prognosis ,Survival Rate ,Oncology ,030220 oncology & carcinogenesis ,Child, Preschool ,Female ,Adult ,medicine.medical_specialty ,Asia ,Adolescent ,Population ,World Health Organization ,03 medical and health sciences ,Young Adult ,medicine ,media_common.cataloged_instance ,Humans ,European Union ,European union ,Mortality ,education ,Survival rate ,Aged ,Cancer Death Rate ,business.industry ,Public health ,Australia ,Infant, Newborn ,Infant ,United States ,030104 developmental biology ,business ,cancer, Russia, Australasia, mortality, projections, lung cancer ,Demography ,Follow-Up Studies - Abstract
Background: Predicted cancer mortality figures and rates are useful for public health planning. Materials and methods: We retrieved cancer death certification data for 10 major cancer sites and total cancers from the World Health Organization (WHO) database and population data from WHO and United Nations Population Division databases. We obtained figures for Russia, Israel, Hong Kong, Japan, the Philippines, Korea, and Australia in 1970-2015. We predicted numbers of deaths by age group and age-standardized rates (world population) for 2018 by applying a linear regression to mortality data of each age group over the most recent trend segment identified by a joinpoint regression model. Results: Russia had the highest predicted total cancer mortality rates, 158.5/100000 men and 84.1/100000 women. Men in the Philippines showed the lowest rates for 2018 (84.6/100000) and Korean males the most favourable predicted fall (21% between 2012 and 2018). Women in Korea had the lowest total cancer predicted rate (52.5/100000). Between 1993 and 2018, i.e. by applying the 1993 rates to populations in subsequent years, a substantial number of cancer deaths was avoided in Russia (1000000 deaths, 821000 in men and 179000 in women), Israel (40000 deaths, 21000 in men and 19000 in women), Hong Kong (63000 deaths, 40000 in men and 23000 in women), Japan (651000 deaths, 473000 in men and 178000 in women), Korea (327000 deaths, 250000 in men and 77000 in women), and Australia (181000 deaths, 125000 in men and 56000 in women). No appreciable reduction in cancer deaths was found in the Philippines. Conclusion: Overall, we predicted falls in cancer mortality. However, these are less marked and later compared with the European Union and United States. Substantial numbers of deaths were avoided in all countries considered except the Philippines. Lung cancer mortality remains exceedingly high in Russian men, despite recent falls.
- Published
- 2019
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