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239 results on '"Carini C"'

1. Mapping the diffusion of circular economy good practices: Success factors and sustainable challenges

Author

Rocca, L, Veneziani, Monica, Carini, Cristian, Veneziani, M (ORCID:0000-0001-8877-8447), Carini, C, Rocca, L, Veneziani, Monica, Carini, Cristian, Veneziani, M (ORCID:0000-0001-8877-8447), and Carini, C

Abstract

Shifting from a linear to a circular economy (CE) is a path promoted from different national and supranational organizations from many years but how that circularity is put in place by businesses from an empirical perspective is still a research gap in the literature. There is the need to stress the study of empirical cases to better understand what are the success factors, the sustainable challenges and the way forward to achieve the goal of a CE. This paper aims to investigate how the circular economy is spreading at the empirical level and with what evolution and opportunities. The framework of the diffusion theory is used to analyse how the CE, as a business model innovation, is widespread. The Italian scenario is taken as background, and 62 good practices of CE are analysed. The results promote a discussion on the attributes of CE, policy implications and future studies to booster the circular changing in society.

Published
2022

2. Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative ABIRISK consortium

Author

Rup, B., Pallardy, M., Sikkema, D., Albert, T., Allez, M., Broet, P., Carini, C., Creeke, P., Davidson, J., De Vries, N., Finco, D., Fogdell-Hahn, A., Havrdova, E., Hincelin-Mery, A., Holland, M. C., Jensen, P. E. H., Jury, E. C., Kirby, H., Kramer, D., Lacroix-Desmazes, S., Legrand, J., Maggi, E., Maillère, B., Mariette, X., Mauri, C., Mikol, V., Mulleman, D., Oldenburg, J., Paintaud, G., Pedersen, C. R., Ruperto, N., Seitz, R., Spindeldreher, S., and Deisenhammer, F.

Published
2015
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4. Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data

Author

Tom, BDM, Symmons, D, Brockbank, S, Carini, C, Cope, AP, Ehrenstein, MR, Fisher, BA, Goodyear, CS, Gozzard, N, Harris, R, Hicks, K, Hollis, S, Hughes-Morley, A, Isaacs, J, Kola, B, McInnes, IB, Mela, CM, Parker, G, Pedersen, AW, Ponchel, F, Sabin, T, Scott, DL, Scott, IC, Sleeman, MA, Taylor, PC, Tsuji, W, Zhong, Y, Hilkens, C, Anderson, A, Stocks, P, Lendrem, D, Tarn, J, Smith, G, Allen, B, Casement, J, Diboll, J, Harry, R, Simpson, G, Toward, R, Noble, H, Parke, A, Wu, W, Clarke, F, Galloway, J, Lempp, H, Ibrahim, F, Schwank, S, Molyneux, G, Lazarov, T, Geissmann, F, Donnelly, I, Gilmour, A, Virlan, AT, Porter, D, Emery, P, El-Jawhari, J, Parmar, R, McDermot, MF, Buch, M, Buckley, C, Young, SP, Jones, P, Raza, K, Filer, A, Pitzalis, C, Barnes, MR, Watson, DS, Tzanis, E, Thorborn, G, Fossati-Jimack, L, Kelly, S, Humby, F, Bombardieri, M, Rana, S, Jia, Z, Goldmann, K, Lewis, M, Altobelli, G, John, C, Martins, S, Nguyen, D, Ali, H, Ciurtin, C, Worthington, J, Bruce, IN, Sergeant, JC, Verstappen, SMM, Stirling, F, Farewell, V, Keidel, S, Cuff, C, Levesque, M, Long, A, Liu, Z, Lipsky, S, Harvey, B, Macoritto, M, Hong, F, Kaymakcalan, S, Ward, N, Talbot, S, Padhji, D, Sleeman, M, Finch, D, Herath, A, Lindholm, C, Jenkins, M, Ho, M, Marshall, C, Page, M, Edwards, H, Cuza, A, Rowe, A, Capdevila, FB, Loza, M, Curran, M, Verbeeck, D, Baker, D, Vranic, I, Mela, CT, Wright, S, Rowell, L, Vernon, E, Joseph, N, Payne, N, Rao, R, Binks, M, Belson, A, Ludbrook, V, Tipney, H, Ellis, J, Hasan, S, Didierlaurent, A, Burny, W, Haynes, A, Larminie, C, Dastros-Pitel, D, Jelinsky, S, Hodge, M, Maciejewski, M, Ziemek, D, Schulz-Knappe, P, Zucht, H-D, Budde, P, Coles, MC, Butler, JA, Read, S, and Consortium, RA-MAP

Subjects
musculoskeletal diseases, immune system diseases, skin and connective tissue diseases
Abstract

Objectives: To identify predictors of remission and disease activity patterns in patients with rheumatoid arthritis (RA) using individual participant data (IPD) from clinical trials. Methods: Phase II and III clinical trials completed between 2002 and 2012 were identified by systematic literature review and contact with UK market authorisation holders. Anonymised baseline and follow-up IPD from non-biological arms were amalgamated. Multiple imputation was used to handle missing outcome and covariate information. Random effects logistic regression was used to identify predictors of remission, measured by the Disease Activity Score 28 (DAS28) at 6 months. Novel latent class mixed models characterised DAS28 over time. Results: IPD of 3290 participants from 18 trials were included. Of these participants, 92% received methotrexate (MTX). Remission rates were estimated at 8.4%(95%CI 7.4%to9.5%) overall, 17%(95%CI 14.8%to19.4%) for MTX-naïve patients with early RA and 3.2% (95% CI 2.4% to 4.3%) for those with prior MTX exposure at entry. In prior MTX-exposed patients, lower baseline DAS28 and MTX reinitiation were associated with remission. In MTX-naïve patients, being young, white, male, with better functional and mental health, lower baseline DAS28 and receiving concomitant glucocorticoids were associated with remission. Three DAS28 trajectory subpopulations were identified in MTX-naïve and MTX-exposed patients. A number of variables were associated with subpopulation membership and DAS28 levels within subpopulations. Conclusions: Predictors of remission differed between MTX-naïve and prior MTX-exposed patients at entry. Latent class mixed models supported differential non-biological therapy response, with three distinct trajectories observed in both MTX-naïve and MTX-exposed patients. Findings should be useful when designing future RA trials and interpreting results of biomarker studies.

Published
2018

5. The RA-MAP Consortium: a working model for academia-industry collaboration

Author

Cope, AP, Barnes, MR, Belson, A, Binks, M, Brockbank, S, Bonachela-Capdevila, F, Carini, C, Fisher, BA, Goodyear, CS, Emery, P, Ehrenstein, MR, Gozzard, N, Harris, R, Hollis, S, Keidel, S, Levesque, M, Lindholm, C, McDermott, MF, McInnes, IB, Mela, CM, Parker, G, Read, S, Pedersen, AW, Ponchel, F, Porter, D, Rao, R, Rowe, A, Schulz-Knappe, P, Sleeman, MA, Symmons, D, Taylor, PC, Tom, B, Tsuji, W, Verbeeck, D, Isaacs, JD, Consortium, Ra-Map, Tom, Brian [0000-0002-3335-9322], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Biomedical Research, Big data, MEDLINE, Globe, History, 21st Century, Article, Arthritis, Rheumatoid, 03 medical and health sciences, Rheumatology, medicine, Genomic medicine, Humans, Industry, Cooperative Behavior, business.industry, Research, Genomics, Public relations, United Kingdom, 030104 developmental biology, medicine.anatomical_structure, Phenotype, Cooperative behavior, business, Biomarkers
Abstract

Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing and fostering new research consortia. This model has percolated down to national funding agencies across the globe, leading to funding for projects that aim to realise the true potential of genomic medicine in the 21st century and to reap the rewards of ‘big data’. In this Perspectives article, the experiences of the RA-MAP consortium, a group of more than 140 individuals affiliated with 21 academic and industry organizations that are focused on making genomic medicine in rheumatoid arthritis a reality are described. The challenges of multi-partner collaboration in the UK are highlighted and wide-ranging solutions are offered that might benefit large research consortia around the world.

Published
2018
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7. Gli effetti del nuovo sistema valutativo sul patrimonio netto e sulle sue componenti

Author

Potito, L, Adamo, S, Costa, M, Aversano, N, Sannino, G, Tartaglia Polcini, P, Fellegara, AM, Quagli, A, Cosentino, A, Coluccia, D, Fontana, S, Giornetti, A, Moscarino, F, Solimene, S, Sura, A, Maglio, R, Agliata, F, Marinoni, MA, Rey, A, Giaccari, F, Magli, F, Ogliari, M, Mari LM, Terzani, S, Braja, EM, Campra, M, Busso, D, Marcon, C, Pucci, S, Venuti, M, Capodaglio G, Darganska, V, Devalle, A, Fradeani, A, Lucchese, M, Rizzato, F, Semprini, L, Sostero, U, Turco, M, Papa, M, Spallini, S, Azzali, S, Fornaciari, L, Mazza, T, Pierotti MR, Bava, F, Doni, F, Fasiello, R, Giovando, G, Teodori, C, Carini, C, Veneziani, M, Incollingo, A, Lionzo, A, Fellegara AM, Potito, L, Adamo, S, Costa, M, Aversano, N, Sannino, G, Tartaglia Polcini, P, Fellegara, AM, Quagli, A, Cosentino, A, Coluccia, D, Fontana, S, Giornetti, A, Moscarino, F, Solimene, S, Sura, A, Maglio, R, Agliata, F, Marinoni, MA, Rey, A, Giaccari, F, Magli, F, Ogliari, M, Mari LM, Terzani, S, Braja, EM, Campra, M, Busso, D, Marcon, C, Pucci, S, Venuti, M, Capodaglio G, Darganska, V, Devalle, A, Fradeani, A, Lucchese, M, Rizzato, F, Semprini, L, Sostero, U, Turco, M, Papa, M, Spallini, S, Azzali, S, Fornaciari, L, Mazza, T, Pierotti MR, Bava, F, Doni, F, Fasiello, R, Giovando, G, Teodori, C, Carini, C, Veneziani, M, Incollingo, A, Lionzo, A, and Fellegara AM

Abstract

Il patrimonio netto aziendale è una misurazione della ricchezza aziendale il cui ammontare sotto il profilo quantitativo discende dai criteri di valutazione adottati per le attività e le passività del bilancio. Si tratta, come noto, di un valore residuale pari alla differenza tra le attività di Stato patrimoniale e le passività. In altre parole, si può definire come l’importo che residua delle attività, dopo aver sottratto tutte le passività (IAS 1). Conseguentemente, le modifiche ai criteri di valutazione prodotte dal D.Lgs. n. 139/2015 si riflettono sull’ammontare del patrimonio netto aziendale. La dimensione quantitativa del patrimonio netto dipende però non soltanto dai criteri di valutazione adottati, ma anche dalle modalità di rappresentazione in bilancio delle operazioni aziendali.

Published
2018

8. Le scritture di chiusura della contabilità economico-patrimoniale armonizzata

Author

Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M, Steccolini, I, Teodori, C, Anzalone M, Mori, Elisa, Elisa Mori (ORCID:0000-0002-0764-893X), Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M, Steccolini, I, Teodori, C, Anzalone M, Mori, Elisa, and Elisa Mori (ORCID:0000-0002-0764-893X)

Abstract

Nei capitoli precedenti abbiamo già trattato alcuni dei momenti fondamentali della tenuta della contabilità economico-patrimoniale; in particolare sono stati affrontati il momento dell’apertura delle rilevazioni in contabilità economico-patrimoniale e quello della rilevazione delle scritture continuative nel corso della gestione, collegate ai movimenti finanziari che si concretizzano durante il periodo amministrativo. Richiamato il concetto di competenza economica, l’obiettivo del capitolo è quello di illustrare gli ultimi due momenti tipici delle rilevazioni in contabilità economico-patrimoniale, ossia la rilevazione delle scritture di assestamento economico al termine dell’esercizio – necessarie alla determinazione del risultato d’esercizio – e la rilevazione delle scritture di chiusura dei conti economici e patrimoniali, necessarie per la predisposizione dei prospetti di bilancio previsti dall’allegato 10 al decreto legislativo n. 118/2011. Il capitolo tiene conto delle modifiche al principio contabile a seguito del D.M. 18 maggio 2017 per quanto riguarda le scritture di assestamento. Al fine di agevolare la lettura e la comprensibilità dei contenuti, i paragrafi alternano spiegazioni teoriche con esempi e soluzioni tecniche, facendo uso di registrazioni al libro giornale, che possono essere adottate nella pratica.

Published
2018

9. Gli elementi di apertura della contabilità economico-patrimoniale armonizzata

Author

Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M., Steccolini, I, Teodori C, Anzalone M, Mori, Elisa, elisa mori (ORCID:0000-0002-0764-893X), Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M., Steccolini, I, Teodori C, Anzalone M, Mori, Elisa, and elisa mori (ORCID:0000-0002-0764-893X)

Abstract

Il presente capitolo ripercorre gli step relativi all’adozione della nuova contabilità economico-patrimoniale per quanto attiene la fase di individuazione degli elementi di apertura e il percorso da seguire per la costruzione/revisione dello stato patrimoniale secondo le indicazioni del principio contabile applicato della contabilità economico-patrimoniale. La redazione dello stato patrimoniale iniziale e delle scritture di apertura costituiscono infatti il punto di avvio per la tenuta della contabilità economica e la successiva registrazione delle scritture continuative d’esercizio, di cui si tratta nei diversi capitoli del testo. Il capitolo persegue un duplice obiettivo: illustrare le attività necessarie alla redazione dello stato patrimoniale iniziale per gli enti che hanno optato per l’avvio della contabilità economico-patrimoniale a decorrere dall’esercizio 2017 (ci si riferisce in particolare ai comuni con popolazione inferiore a 5.000 abitanti per i quali tale possibilità, come è stato già accennato in apertura del volume, è stata prevista dall’art. 232 del TUEL) e contestualmente ripercorrere quanto già realizzato dagli enti che hanno avviato la contabilità economico-patrimoniale negli esercizi precedenti, in un’ottica di revisione dei passaggi compiuti al fine di correggere eventuali errori o mancanze e di apportare le integrazioni necessarie a seguito degli aggiornamenti apportati al principio contabile applicato. Il capitolo fornisce supporto pratico al lettore, presentando delucidazioni circa i procedimenti da seguire ed esempi pratici relativi alle scritture di inizio periodo.

Published
2018

10. FRI0373 Long-term follow-up of 320 children born to mothers with systemic autoimmune diseases: a multicentre italian survey from 24 rheumatology centres

Author

Lazzaroni, M.G., primary, Nalli, C., additional, Andreoli, L., additional, Carini, C., additional, Bartoloni-Bocci, E., additional, Gerli, R., additional, Chighizola, C.B., additional, Gerosa, M., additional, Meroni, P.L., additional, Sinigaglia, L., additional, Conigliaro, P., additional, Perricone, R., additional, Corrado, A., additional, Cantatore, F., additional, D’Angelo, S., additional, Favaro, M., additional, Larosa, M., additional, Doria, A., additional, Ruffatti, A., additional, Generali, E., additional, Selmi, C., additional, Meroni, M., additional, Cutolo, M., additional, Padovan, M., additional, Govoni, M., additional, Pazzola, G., additional, Salvarani, C., additional, Peccatori, S., additional, Paolazzi, G., additional, Prevete, I., additional, Sebastiani, G.D., additional, Minisola, G., additional, Brucato, A., additional, Ramoni, V., additional, Caporali, R., additional, Montecucco, C., additional, Tani, C., additional, Signorini, V., additional, Mosca, M., additional, Trevisani, M., additional, Malavolta, N., additional, Vadacca, M., additional, Afeltra, A., additional, Vivaldelli, E., additional, Maier, A., additional, Visalli, E., additional, Foti, R., additional, Zuliani, L., additional, Gabrielli, A., additional, Campochiaro, C., additional, Baldissera, E., additional, Sabbadini, M.G., additional, Romeo, N., additional, and Tincani, A., additional

Published
2018
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11. PS4:79 Long-term follow-up of 320 chilren born to mothers with systemic autoimmune diseases: a multicentre survey from 24 rheumatology centres in italy

Author

Lazzaroni, MG, primary, Nalli, C, additional, Andreoli, L, additional, Carini, C, additional, Dall’Ara, F, additional, Rodrigues, M, additional, Bartoloni Bocci, E, additional, Gerli, R, additional, Chighizola, CB, additional, Gerosa, M, additional, Meroni, PL, additional, Sinigaglia, L, additional, Conigliaro, P, additional, Perricone, R, additional, Corrado, A, additional, Cantatore, F, additional, D’Angelo, S, additional, Favaro, M, additional, Larosa, M, additional, Doria, A, additional, Ruffatti, A, additional, Generali, E, additional, Selmi, C, additional, Meroni, M, additional, Cutolo, M, additional, Padovan, M, additional, Govoni, M, additional, Pazzola, G, additional, Salvarani, C, additional, Peccatori, S, additional, Prevete, I, additional, Minisola, G, additional, Sebastiani, GD, additional, Brucato, A, additional, Ramoni, V, additional, Caporali, R, additional, Montecucco, C, additional, Tani, C, additional, Signorini, V, additional, Mosca, M, additional, Trevisani, M, additional, Malavolta, N, additional, Vadacca, M, additional, Afeltra, A, additional, Vivaldelli, E, additional, Maier, A, additional, Visalli, E, additional, Foti, R, additional, Zuliani, L, additional, Gabrielli, A, additional, Campochiaro, C, additional, Baldissera, E, additional, Sabbadini, MG, additional, Romeo, N, additional, and Tincani, A, additional

Published
2018
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12. Gli elementi di apertura della contabilità economico-patrimoniale armonizzata

Author

Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M, Steccolini, I, Teodori C, Mori, Elisa, Mori E (ORCID:0000-0002-0764-893X), Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M, Steccolini, I, Teodori C, Mori, Elisa, and Mori E (ORCID:0000-0002-0764-893X)

Abstract

Il presente capitolo tratta gli step relativi all’adozione della nuova contabilità economico-patrimoniale per quanto attiene la fase di individuazione degli elementi di apertura e il percorso da seguire per la costruzione del primo stato patrimoniale secondo le indicazioni del principio contabile applicato della contabilità economico-patrimoniale. La redazione dello stato patrimoniale iniziale e delle scritture di apertura rappresentano infatti il prerequisito essenziale alla tenuta della contabilità economica e alla registrazione delle scritture continuative d’esercizio, di cui si tratta nei diversi capitoli del presente testo. L’obiettivo del capitolo è quello di illustrare le attività necessarie alla redazione dello stato patrimoniale iniziale fornendo delucidazioni circa i procedimenti da seguire ed esempi pratici relativi alle scritture di inizio periodo.

Published
2017

13. Le scritture di chiusura della contabilità economico-patrimoniale armonizzata

Author

Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M, Steccolini, I, Teodori C, Anzalone, M., Mori, Elisa, Mori, E (ORCID:0000-0002-0764-893X), Anzalone, M, Anessi Pessina, E, Carini, C, Giacomini, D, Mori, E, Sicilia, M, Steccolini, I, Teodori C, Anzalone, M., Mori, Elisa, and Mori, E (ORCID:0000-0002-0764-893X)

Abstract

Nei capitoli precedenti abbiamo già trattato alcuni dei momenti fondamentali della tenuta della contabilità economico-patrimoniale; in particolare sono stati affrontati il momento dell’apertura delle rilevazioni in contabilità economico-patrimoniale e quello della rilevazione delle scritture continuative nel corso della gestione, collegate ai movimenti finanziari che si concretizzano durante il periodo amministrativo. Richiamato il concetto di competenza economica, l’obiettivo del capitolo è quello di illustrare gli ultimi due momenti tipici delle rilevazioni in contabilità economico-patrimoniale, ossia la rilevazione delle scritture di assestamento economico al termine dell’esercizio, necessarie alla determinazione del risultato d’esercizio, e la rilevazione delle scritture di chiusura dei conti economici e patrimoniali, necessarie per la predisposizione dei prospetti di bilancio previsti dall’Allegato 10 al decreto legislativo n. 118/2011. Al fine di agevolare la lettura e la comprensibilità dei contenuti, i paragrafi alternano spiegazioni teoriche con esempi e soluzioni tecniche, facendo uso di registrazioni al libro giornale, che possono essere adottate nella pratica.

Published
2017

14. AB1099 Counselling on family planning and contraception, and pregnancy outcome in women with rheumatic diseases: a national survey of 398 patient-reported questionnaires from 24 rheumatology centers

Author

Lazzaroni, MG, primary, Dall'Ara, F, additional, Andreoli, L, additional, Carini, C, additional, Rodrigues, M, additional, Reggia, R, additional, Bartoloni-Bocci, E, additional, Gerli, R, additional, Chighizola, CB, additional, Gerosa, M, additional, Meroni, PL, additional, Sinigaglia, L, additional, Conigliaro, P, additional, Perricone, R, additional, Corrado, A, additional, Cantatore, FP, additional, D'Angelo, S, additional, Olivieri, I, additional, Favaro, M, additional, Doria, A, additional, Ruffatti, A, additional, Generali, E, additional, Selmi, C, additional, Meroni, M, additional, Cutolo, M, additional, Padovan, M, additional, Govoni, M, additional, Pazzola, G, additional, Salvarani, C, additional, Peccatori, S, additional, Paolazzi, G, additional, Prevete, I, additional, Sebastiani, GD, additional, Minisola, G, additional, Brucato, A, additional, Ramoni, V, additional, Caporali, R, additional, Montecucco, C, additional, Tani, C, additional, Mosca, M, additional, Trevisani, M, additional, Malavolta, N, additional, Vadacca, M, additional, Afeltra, A, additional, Vivaldelli, E, additional, Maier, A, additional, Baldissera, E, additional, Visalli, E, additional, Foti, R, additional, Zuliani, L, additional, Gabrielli, A, additional, Romeo, N, additional, and Tincani, A, additional

Published
2017
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15. THU0611 Long-term follow-up of 269 children born to mothers with systemic autoimmune diseases: a national survey from 24 rheumatology centers

Author

Nalli, C, primary, Andreoli, L, additional, Carini, C, additional, Rodrigues, M, additional, Dall'Ara, F, additional, Lazzaroni, MG, additional, Bartoloni-Bocci, E, additional, Chighizola, CB, additional, Campochiaro, C, additional, Conigliaro, P, additional, Corrado, A, additional, D'Angelo, S, additional, Favaro, M, additional, Generali, E, additional, Gerosa, M, additional, Larosa, M, additional, Meroni, M, additional, Padovan, M, additional, Pazzola, G, additional, Peccatori, S, additional, Prevete, I, additional, Ramoni, V, additional, Sebastiani, G, additional, Signorini, V, additional, Tani, C, additional, Trevisani, M, additional, Vadacca, M, additional, Vivaldelli, E, additional, Visalli, E, additional, Zuliani, L, additional, Afeltra, A, additional, Baldissera, E, additional, Brucato, A, additional, Cantatore, FP, additional, Caporali, R, additional, Cutolo, M, additional, Doria, A, additional, Foti, R, additional, Gabrielli, A, additional, Gerli, R, additional, Govoni, M, additional, Maier, A, additional, Malavolta, N, additional, Meroni, PL, additional, Minisola, G, additional, Montecucco, CM, additional, Mosca, M, additional, Olivieri, I, additional, Paolazzi, G, additional, Perricone, R, additional, Romeo, N, additional, Ruffatti, A, additional, Sabbadini, MG, additional, Salvarani, C, additional, Selmi, C, additional, Sinigaglia, L, additional, and Tincani, A, additional

Published
2017
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21. Changes of nuclear PI-PLC gamma(1) during rat liver regeneration

Author

Neri, Luca Maria, Ricci, Daniele, Carini, C, Marchisio, M, Capitani, Silvano, and Bertagnolo, Valeria

Subjects
Rat liver, Confocal microscopy, Inositide cycle, Nucleus, Inositide cycle, Phosphoinositidases, Rat liver, Liver regeneration, Confocal microscopy, Liver regeneration, Phosphoinositidases, Nucleus
Published
1997

22. Nuclear phosphoinositide-specific phospholipase C, phosphatidylinositol 4,5-bisphosphate and protein kinase C during rat spermatogenesis

Author

Caramelli E, Matteucci A, NICOLETTA ZINI, Carini C, Guidotti L, Ricci D, Nm, Maraldi, and Capitani S

Subjects
Male, Phosphatidylinositol 4,5-Diphosphate, Phosphoric Diester Hydrolases, Phosphatidylinositol Diacylglycerol-Lyase, Immunohistochemistry, Spermatozoa, Rats, Rats, Sprague-Dawley, Microscopy, Electron, Germ Cells, Animals, Spermatogenesis, Protein Kinase C, Signal Transduction
Abstract

Presence and intracellular distribution of phosphoinositide-specific phospholipase C, phosphatidylinositol 4,5-bisphosphate and protein kinase C have been investigated in rat maturing germ cells and spermatozoa. The isoforms beta 1 and gamma 1 of phosphoinositide-specific phospholipase C were immunologically identified and found to be predominantly nuclear or cytoplasmic and nuclear, respectively. The two enzymes were present in the maturing cell lineage of the seminiferous tubule, except for the nucleus of late spermatids, and absent in spermatozoa, in which, however, a phosphoinositide-specific phospholipase C activity persisted, due to yet uncharacterized enzyme(s). Protein kinase C paralleled these developmental changes, and was completely down-regulated in both total cell homogenates and isolated nuclei obtained from spermatozoa. On the contrary, phosphatidylinositol 4,5-bisphosphate, present at the nuclear level in all cell types, accumulated in the nuclei of late spermatids and spermatozoa. These data support the contention that the spermatozoon nucleus stores a lipid-dependent signaling apparatus which could be reactivated either during sperm maturation or at fertilization.

Published
1996

25. The first case of congenital lactase deficiency in Italy

Author

Gatti, S., primary, Biagioni, M., additional, Biagetti, C., additional, Romagnoli, V., additional, Pambianchi, M., additional, Carini, C., additional, D’Alba, I., additional, Torniainen, Suvi, additional, Savilahti, Erkki, additional, Järvelä, Irma, additional, and Catassi, C., additional

Published
2008
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34. A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+CD23+ T-cell subset.

Author

Fratazzi, C. and Carini, C.

Subjects
*INTERLEUKINS, *T cells, *CD23 antigen, *LYMPHOCYTES, *CELLULAR immunity
Abstract

Background The low affinity receptor for IgE, CD23, has been described in several pathological conditions. However, the factors involved in the upregulation or downregulation of this receptor are still debated. Methods and Results We studied the effect of interleukin 7 (IL 7) on the expression of CD23 in normal PBT cells stimulated with PMA + Ca2. The data indicate that activated PB-T cultured in the presence of IL-7 showed an increased expression of CD23. The induction of IL-7 on CD23 production appears to be independent of IL-2, IL-4, IL-9, IL-15, Indeed, the addition of specific MoAbs anti-IL-2. IL-4. IL-9. IL-15 or anti-IL2R was unable to block the effect of IL-7 on CD23. The addition of IL-7 to a specific subset CD4+CD23+ was able to augment the adhesiveness of T cells to parenchynial cell monalayers. The use of different cytokine (IL-2, IL-4, IL-9, IL-15) resulted in no increase of adhesiveness. In contrast the addition of IL-7 to a different T-cell subset (i.e. CD4+CD23-) was unable to rescue the lack of adhesiveness observed in these cells. Blocking experiments with MHM6 MoAb were able to drastically reduce the adhesiveness observed in CD4+CD23+ subsets. The presence of LFA-1 and VLA-4 adhesion molecules were responsible for the augmented adhesiveness of activated CD4+CD23+ T cells cultured in the presence of IL-7. Blocking experiments with anti-LFA-1, VLA-4. anti-LFA-1β plus VLA-4α MoAbs or anti-ICAM-1 MoAb added to the monolayers resulted in a complete inhibition of adhesion to parenchymal monolayers. In contrast, the addition of anti-IL-7 or anti-lL-7R MoAbs were able to block the augmented adhesiveness of CD4+CD23+ cells to monolayers observed in the presence of IL-7. Conclusion Taken together these findings point to the likelihood that IL-7 is responsible for the observed quantitative difference in the level of adhesion molecules and may open a new role of CD23 in the immune regulation. [ABSTRACT FROM AUTHOR]

Published
1997
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38. Evidence for activation of complement in patients with AIDS related complex (ARC) and/or lymphoadenopathy syndrome (LAS).

Author

Perricone, R., Fontana, L., De Carolis, Caterina, Carini, C., Sirianni, Maria Caterina, and Aiuti, F.

Subjects
AIDS patients, HIV-positive persons, ENZYME activation, SYNDROMES, GAY people, DRUG abuse
Abstract

The complement system was examined in 16 patients with AIDS-related complex (ARC) (n = 5) and/or lymphoadenopathy syndrome (LAS) (n = 11). Of these patients 62-5% showed an impairment of classical and/or alternative pathway activity associated with the presence of cleavage fragments of C3 and/or B and a significant reduction of many complement factors. The data indicate pathological complement activation in these patients through the classical and/or alternative pathway. Complement activation was more severe in patients with ARC than in those with LAS, and greater in drug abusers than homosexuals. The lack of efficient complement in the patients can be considered an 'acquired complement deficiency' with possible importance in the failure to combat the HIV attack. [ABSTRACT FROM AUTHOR]

Published
1987

39. Complement Activation is Associated with the Presence of Specific Human Immunodeficiency Virus (HIV)-Anti-HIV Immune Complexes in Patients with Acquired Immunodeficiency Syndrome-Related Complex or Lymphoadenopathy Syndrome.

Author

Carini, C., Perriconie, R., Fratazzi, C., Fontana, L., De Carolis, C., D'Amelio, R., Sirianni, M.C., and Aiuti, F.

Subjects
HIV-positive persons, AIDS, IMMUNITY, ENZYME activation, ANTIGENS, IMMUNOGLOBULINS
Abstract

The complement system was examined in a group of eight patients (six with lymphoadenopathy syndrome (LAS); two with acquired immunodeficiency syndrome (AIDS)-related complex (ARC), who were found to be human immunodeficiency virus (HIV)-positive, for the presence of specific HIV-anti-HIV complexes. A significant impairment of the classical and/or alternative pathway was found associated with the presence of cleavage fragments of C3 and/or B and a significant reduction in the complement factors studied. Ultracentrifugation fractions of serum samples obtained from one of the patients were assessed for the detection of specific HIV-anti-HIV (GP4I-anti-GP4I) complexes and were incubated with normal human serum to determine their complement activation capacity. A clear complement activation was found with the fraction in which a clear peak of HIV-anti-HIV (GP4I-anti-GP4I) immune complexes was present. The results demonstrate that specific immune complexes and complement activation are sometimes concomitantly present in patients with AIDS-related disease and that specific immune complexes may be one of the causal factors of the pathogenesis of complement activation in these patients. Possible consequences for the severe immune regulation with relevance to the dramatic failure in treating the virus effectively are discussed. [ABSTRACT FROM AUTHOR]

Published
1989
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40. Characterization of Specific Immune Complexes in HIV-Related Disorders.

Author

Carini, C., Mezzaroma, I., Scano, G., D'Amelio, R., Matricardi, P., and Aiuti, F.

Subjects
HIV infections, HIV, DISEASES, LENTIVIRUS diseases, IMMUNE complexes, IMMUNOGLOBULINS, ANTIGENS, IMMUNOLOGY
Abstract

Eighty-seven seropositive subjects with HIV (human immunodeficiency virus) infection together with 20 normal controls with no history of any illness were investigated for the presence of circulating immune complexes (CIC) by the conglutinin binding assay (KgBA) and further studied for isotype characterization of CIC. Six out of 87 patients showing very high values for immune complexes (CIC) were studied for the presence of free antigen. In 3 out of 6 (1, IVc1;1, III: 1, IVa) we could detect by ultracentrifugation analysis the presence of specific HIV (p15) anti-HIV (anti-pl5) and gp41-anti-gp4l CIC. Evidence in favour of this finding is supported by: (1) the presence of specific CIC (pl5-anti-pl5 or gp4)-anti-gp41) seen only at pH 7.2; (2) the apparent presence of free antigen and specific HIV antibodies were only at pH 4.0. The relevance of this finding lies in the attempt to explain the occurrence of false seronegativity seen occasionally in symptomatic patients. Thus, the presence of CIC might perhaps interfere in the routine assay (i.e. ELISA) making the diagnosis difficult. All these considerations will have to be taken into account in the future handling of this disease. [ABSTRACT FROM AUTHOR]

Published
1987

44. Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

Author

Carini, C, Margolick, J, Yodoi, J, and Ishizaka, K

Abstract

Peripheral blood mononuclear cells of 10 out of 26 patients with human immunodeficiency virus type 1 (HIV-1) released IgE-binding factors, as determined by two independent assays. The formation of the factors by the mononuclear cells was enhanced by incubation of the cells with homologous IgE. In the presence of IgE, peripheral blood mononuclear cells from 15 of the 26 patients formed a detectable amount of IgE-binding factors, whereas those of normal individuals of allergic rhinitis patients failed to do so. The major source of IgE-binding factors was the T cells of the HIV-1-infected patients. The CD8+ T cells from a HIV-1-infected patient formed IgE-binding factors upon incubation with IgE, and type II receptors for Fc epsilon were detected on both CD4+ T cells and CD8+ T cells in one of five patients studied. It was also found that culture supernatants of mononuclear cells from HIV-1-infected patients released soluble factors that induce normal human T cells to form IgE-binding factors. The results suggest that lymphocytes of some HIV-1-infected patients are activated to produce lymphokines regulating formation of IgE-binding factors.

Published
1988
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