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5. Active Balun Design for Next-Generation Telecom Satellite Frequency Converters

Author

Resca, D, Bosi, G, Biondi, A, Cariani, L, Vadalà, V, Scappaviva, F, Raffo, A, Vannini, G, Resca D., Bosi G., Biondi Andrea, Cariani L., Vadalà Valeria, Scappaviva F., Raffo A., Vannini G., Resca, D, Bosi, G, Biondi, A, Cariani, L, Vadalà, V, Scappaviva, F, Raffo, A, Vannini, G, Resca D., Bosi G., Biondi Andrea, Cariani L., Vadalà Valeria, Scappaviva F., Raffo A., and Vannini G.

Abstract

In this work, we describe the complete design flow of a 1.3–3.3-GHz active balun, exploited to generate a high-voltage swing differential local oscillator (LO) signal driving a highly linear doubly balanced resistive ring mixer. Both the LO active balun and the mixer are integrated into a -band single chip monolithic microwave integrated circuits (MMIC) downconverter for the state-of-the-art telecom satellites. System performance has been maximized designing the different circuits by a holistic approach, which considers a non 50- environment. The experimental validation is carried out by means of an ad hoc time-domain load–pull test bench and shows that the LO active balun provides two quasi-sinusoidal, 180 out-phased, signals with 2.4-V peak-to-peak voltage to the input ports of the mixer over a very high-impedance loading condition.

Published
2023

8. Advances in Ku-Band GaN Single Chip Front End for Space SARs: From System Specifications to Technology Selection

Author

Scappaviva, F, Bosi, G, Biondi, A, D'Angelo, S, Cariani, L, Vadalà, V, Raffo, A, Resca, D, Cipriani, E, Vannini, G, Scappaviva F., Bosi G., Biondi A., D'Angelo S., Cariani L., Vadalà Valeria, Raffo A., Resca D., Cipriani E., Vannini G., Scappaviva, F, Bosi, G, Biondi, A, D'Angelo, S, Cariani, L, Vadalà, V, Raffo, A, Resca, D, Cipriani, E, Vannini, G, Scappaviva F., Bosi G., Biondi A., D'Angelo S., Cariani L., Vadalà Valeria, Raffo A., Resca D., Cipriani E., and Vannini G.

Abstract

In this paper, a single-chip front-end (SCFE) operating in Ku-band (12–17 GHz) is presented. It is designed exploiting a GaN on SiC technology featured by 150 nm gate length provided by UMS foundry. This MMIC integrates high power and low noise amplification functions enabled by a single-pole double-throw (SPDT) switch, occupying a total area of 20 mm2. The transmitting chain (Tx) presents a 39 dBm output power, a power added efficiency (PAE) higher than 30% and a 22 dB power gain. The receive path (Rx) offers a low noise figure (NF) lower than 2.8 dB with 25 dB of linear gain. The Rx port output power leakage is limited on chip to be below 15 dBm even at high compression levels. Finally, a complete characterization of the SCFE in the Rx and Tx modes is presented, also showing the measurement of the recovery time in the presence of large-signal interferences.

Published
2022

11. P146 Microbiological diagnostic procedures for respiratory cystic fibrosis samples: results of a survey in Italian laboratories

Author

Dolce, D., primary, Ravenni, N., additional, Campana, S., additional, Gualdi, P., additional, Mancuso, G., additional, Pezzotta, R., additional, Fiscarelli, E.V., additional, Medici, C., additional, Catania, M.R., additional, Borio, T., additional, Francescon, M.V., additional, Busetti, M., additional, Valentini, S., additional, Grassi, P., additional, Antonelli, G., additional, Pedna, M.F., additional, Favari, F., additional, Rapagnani, S., additional, Cariani, L., additional, Curtoni, A., additional, D’Aprile, A., additional, Di Bernardo, F., additional, and Taccetti, G., additional

Published
2022
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28. Fatal respiratory infection due to ST308 VIM-1-producing Pseudomonas aeruginosa in a lung transplant recipient: case report and review of the literature.

Author

Carugati, M., Piazza, A., Peri, A. M., Cariani, L., Brilli, M., Girelli, D., Di Carlo, D., Gramegna, A., Pappalettera, M., Comandatore, F., Grasselli, G., Cantù, A. P., Arghittu, M., Gori, A., Bandi, C., Blasi, F., Bandera, A., and IFALT working group

Abstract

Background: Data regarding the prevalence of metallo-β-lactamases (MBLs) among Pseudomonas aeruginosa isolates in cystic fibrosis patients are scarce. Furthermore, there is limited knowledge on the effect of MBL production on patient outcomes. Here we describe a fatal respiratory infection due to P. aeruginosa producing VIM-type MBLs in a lung transplant recipient and the results of the subsequent epidemiological investigation.Case Presentation: P. aeruginosa isolates collected in the index patient and among patients temporally or spatially linked with the index patient were analyzed in terms of antibiotic susceptibility profile and MBL production. Whole-genome sequencing and phylogenetic reconstruction were also performed for all P. aeruginosa isolates producing VIM-type MBLs. A VIM-producing P. aeruginosa strain was identified in a lung biopsy of a lung transplant recipient with cystic fibrosis. The strain was VIM-1-producer and belonged to the ST308. Despite aggressive treatment, the transplant patient succumbed to the pulmonary infection due to the ST308 strain. A VIM-producing P. aeruginosa strain was also collected from the respiratory samples of a different cystic fibrosis patient attending the same cystic fibrosis center. This isolate harbored the blaVIM-2 gene and belonged to the clone ST175. This patient did not experience an adverse outcome.Conclusions: This is the first description of a fatal infection due to P. aeruginosa producing VIM-type MBLs in a lung transplant recipient. The circulation of P. aeruginosa isolates harboring MBLs pose a substantial risk to the cystic fibrosis population due to the limited therapeutic options available and their spreading potential. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Drug development of new N-methylthio-azetidinones and linezolid-like compounds active against Staphylococcus aureus isolated from cystic fibrosis patients: in vitro and in vivo biological evaluation

Author

MUSUMECI, ROSARIO, SANCINI, GIULIO ALFREDO, BULBARELLI, ALESSANDRA, OGGIONI, DAVIDE, MADEO, MOIRA, LONATI, ELENA RITA, DAL MAGRO, ROBERTA, COCUZZA, CLEMENTINA ELVEZIA, Colombo, C, Cariani, L, Teri, A, Galletti, P, Tolomelli, A, Gentilucci, L, Giacomini, D, Pace, A, Piccionello, A, Gasco, P, Musumeci, R, Sancini, G, Bulbarelli, A, Oggioni, D, Madeo, M, Lonati, E, DAL MAGRO, R, Colombo, C, Cariani, L, Teri, A, Galletti, P, Tolomelli, A, Gentilucci, L, Giacomini, D, Pace, A, Piccionello, A, Gasco, P, and Cocuzza, C

Subjects
MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, Drug development, N-methylthio-azetidinones, linezolid-like compounds, Staphylococcus aureus, cystic fibrosis
Published
2014

31. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

Author

Iannitti, R.G., Napolioni, V., Oikonomou, V., Luca, A. De, Galosi, C., Pariano, M., Massi-Benedetti, C., Borghi, M., Puccetti, M., Lucidi, V., Colombo, C., Fiscarelli, E., Lass-Florl, C., Majo, F., Cariani, L., Russo, M., Porcaro, L., Ricciotti, G., Ellemunter, H., Ratclif, L., Benedictis, F.M. De, Talesa, V.N., Dinarello, C.A., Veerdonk, F.L. van de, Romani, L., Iannitti, R.G., Napolioni, V., Oikonomou, V., Luca, A. De, Galosi, C., Pariano, M., Massi-Benedetti, C., Borghi, M., Puccetti, M., Lucidi, V., Colombo, C., Fiscarelli, E., Lass-Florl, C., Majo, F., Cariani, L., Russo, M., Porcaro, L., Ricciotti, G., Ellemunter, H., Ratclif, L., Benedictis, F.M. De, Talesa, V.N., Dinarello, C.A., Veerdonk, F.L. van de, and Romani, L.

Abstract

Contains fulltext : 172723.pdf (publisher's version ) (Open Access), Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory responses in mice and humans with cystic fibrosis (CF), a life-threatening disorder of the lungs and digestive system. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in CF and correlates with defective NLRC4-dependent IL-1Ra production. Disease susceptibility in mice and microbial colonization in humans occurrs in conditions of genetic deficiency of NLRC4 or IL-1Ra and can be rescued by administration of the recombinant IL-1Ra, anakinra. These results indicate that pathogenic NLRP3 activity in CF could be negatively regulated by IL-1Ra and provide a proof-of-concept evidence that inflammasomes are potential targets to limit the pathological consequences of microbial colonization in CF.

Published
2016

33. Early antibiotic treatment for Pseudomonas aeruginosa eradication in patients with cystic fibrosis: a randomised multicentre study comparing two different protocols

Author

Taccetti, G, Bianchini, E, Cariani, L, Buzzetti, R, Costantini, D, Trevisan, F, Zavataro, L, Campana, S, Minicucci, Laura, and aeruginosa Eradication in Cystic Fibrosis, Italian Group for P.

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cystic Fibrosis, Stenotrophomonas maltophilia, Administration, Oral, medicine.disease_cause, Cystic fibrosis, law.invention, Randomized controlled trial, Ciprofloxacin, law, Forced Expiratory Volume, Internal medicine, Administration, Inhalation, Tobramycin, Humans, Medicine, Pseudomonas Infections, Child, Chi-Square Distribution, Intention-to-treat analysis, biology, Colistin, business.industry, Pseudomonas aeruginosa, Infant, medicine.disease, biology.organism_classification, Anti-Bacterial Agents, Surgery, Treatment Outcome, Child, Preschool, Drug Therapy, Combination, Female, business, medicine.drug
Abstract

Background Pseudomonas aeruginosa chronic pulmonary infection is an unfavourable event in cystic fibrosis. Bacterial clearance is possible with an early antibiotic treatment upon pathogen isolation. Currently, no best practice exists for early treatment. The efficacy of two different regimens against initial P aeruginosa infection was assessed. Methods In a randomised, open-label, parallel-group study involving 13 centres, the superiority of inhaled tobramycin/oral ciprofloxacin compared with inhaled colistin/oral ciprofloxacin (reference treatment) over 28 days was evaluated. Patients were eligible if they were older than 1 year with first or new P aeruginosa isolation. Treatments were assigned equally by centralised balanced randomisation, stratified by age and forced expiratory volume in 1 s values. The participants and those giving the intervention were not masked to arm assignments. The primary endpoint was P aeruginosa eradication, defined as three successive negative cultures in 6 months. Analysis was by intention to treat. This trial was registered with EudraCT, number 2008-006502-42. Results 105 patients were assigned to inhaled colistin/oral ciprofloxacin (arm A) and 118 to inhaled tobramycin/oral ciprofloxacin (arm B). All patients were analysed. P aeruginosa was eradicated in 66 (62.8%) patients in arm A and in 77 (65.2%) in arm B (OR 0.90, 95% CI 0.52 to 1.55, p=0.81). Following treatment, an increase in Stenotrophomonas maltophilia was noted (OR 3.97, 95% CI 2.27 to 6.94, p=0.001) with no differences between the two arms (OR 0.89, 95% CI 0.44 to 1.78, p=0.88). Conclusions No superiority of treatment under study was demonstrated in comparison to the reference treatment. Early eradication treatment was associated with an increase in S maltophilia .

Published
2012

39. Drug development of new N-methylthio-azetidinones and linezolid-like compounds active against Staphylococcus aureus isolated from cystic fibrosis patients: in vitro and in vivo biological evaluation

Author

Musumeci, R, Sancini, G, Bulbarelli, A, Oggioni, D, Madeo, M, Lonati, E, DAL MAGRO, R, Colombo, C, Cariani, L, Teri, A, Galletti, P, Tolomelli, A, Gentilucci, L, Giacomini, D, Pace, A, Piccionello, A, Gasco, P, Cocuzza, C, MUSUMECI, ROSARIO, SANCINI, GIULIO ALFREDO, BULBARELLI, ALESSANDRA, OGGIONI, DAVIDE, MADEO, MOIRA, LONATI, ELENA RITA, DAL MAGRO, ROBERTA, COCUZZA, CLEMENTINA ELVEZIA, Musumeci, R, Sancini, G, Bulbarelli, A, Oggioni, D, Madeo, M, Lonati, E, DAL MAGRO, R, Colombo, C, Cariani, L, Teri, A, Galletti, P, Tolomelli, A, Gentilucci, L, Giacomini, D, Pace, A, Piccionello, A, Gasco, P, Cocuzza, C, MUSUMECI, ROSARIO, SANCINI, GIULIO ALFREDO, BULBARELLI, ALESSANDRA, OGGIONI, DAVIDE, MADEO, MOIRA, LONATI, ELENA RITA, DAL MAGRO, ROBERTA, and COCUZZA, CLEMENTINA ELVEZIA

Published
2014

44. Transmission of Burkholderia cepacia complex: evidences of new epidemic clones in Italian CF population

Author

Campana, S., Taccetti, G., Ravenni, N., Favari, F., Cariani, L., Sciacca, A., Bianco, O., Pensabene, T., Fiscarelli, E., DE INTINIS, G., Busetti, M., Cipolloni, A., A. D, Aprile, Gioffr, F., Collebrusco, I., Frontini, P., Stassi, Giovanna, Magni, A., Tovagliari, D., Lavitola, A., Doherty, Cj, Jrw, Govan, Vandamme, P., CYSTIC FIBROSIS CENTER, DEPARTMENT OF PAEDIATRICS, UNIVERSITY OF FLORENCE, Florence, Italy, DEPARTMENT OF MEDICAL MICROBIOLOGY, UNIVERSITY OF EDINBURGH, Edinburgh, Uk, LABORATORIUM VOOR MICROBIOLOGIE, Universiteit, Ghent, Ghent, Belgium, and ITALIAN GROUP OF CYSTIC FIBROSIS MICROBIOLOGIST

Published
2004

45. Evaluation of the risk of fungal colonization/infection in patients with cystic fibrosis: An international prospective study comparing the performance of media for mycological culturing MucoFong International Project (MFIP)

Author

Touati, K., primary, Faure, C.O., additional, Cornet, M., additional, Botterel, F., additional, Dannaoui, E., additional, Morio, F., additional, Lepape, P., additional, Grenouillet, F., additional, Favennec, L., additional, Le Gal, S., additional, Nevez, G., additional, Borman, A., additional, Saegeman, V., additional, Lagrou, K., additional, Gomez, E., additional, Caro-Luis, M., additional, Canton, R., additional, Campana, S., additional, Buzina, W., additional, Chen, S., additional, Meyer, W., additional, Roilides, E., additional, Simitsopoulou, M., additional, Manso, E., additional, Cariani, L., additional, Biffi, A., additional, Fiscarelli, E., additional, Riccioti, G., additional, Sendid, B., additional, Pihet, M., additional, Bouchara, J.-P., additional, and Delhaes, L., additional

Published
2014
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48. 132 MRSA epidemiology: a different diffusion in Italian cystic fibrosis centres

Author

Cocchi, P., primary, Cariani, L., additional, Favari, F., additional, Fiscarelli, E., additional, Pensabene, T., additional, Manso, E., additional, Gioffre, F.V., additional, Busetti, M., additional, d'Aprile, A., additional, Borio, T., additional, Lambíase, A., additional, Taccetti, G., additional, Braggion, C., additional, de Martino, M., additional, and Campana, S., additional

Published
2012
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