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278 results on '"Cardozo, Ludmila"'

4. Contributors

Author

Abbasi-Maleki, Saeid, primary, Afraz, Elham Sadat, additional, Aliani, Michel, additional, Bianchi, Vittorio Emanuele, additional, Cardozo, Ludmila FMF, additional, Chen, Shumin, additional, Elshahaly, Mohsen, additional, Eskin, Michael N.A., additional, Fahmi, Ronak, additional, Gavel, Nicole, additional, Goldberg, Erin, additional, Grizzi, Fabio, additional, Haghipanah, Motahareh, additional, Hamasaki, Hidetaka, additional, Hegab, Mohsen M., additional, Hegazi, Mohamed A.A.A., additional, Khalifa, Abdulwahab Al, additional, Li, Peng, additional, Mafra, Denise, additional, Matrisciano, Francesco, additional, Merchant, Michele A., additional, Mogawer, Enas S., additional, Moradikor, Nasrollah, additional, Naiebi, Raika, additional, Pierce, Grant N., additional, Ragab, Gaafar, additional, Richard, Melanie N., additional, Rodriguez-Leyva, Delfin, additional, Ryland, Donna, additional, Saadat, Maryam, additional, Song, Cai, additional, Spence, Charles, additional, Stenvinkel, Peter, additional, Yi, Zhenwei, additional, Yin, Hao, additional, Zhang, Boya, additional, Zhao, Liming, additional, Zhao, Mengyao, additional, and Zhuang,, Xinye, additional

Published
2024
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6. Effects of intradialytic bicycle ergometer exercise on transcription factors NF-ĸB and Nrf2 in patients with chronic kidney disease: A randomized crossover clinical trial

Author

Brito, Jessyca Sousa de, Borges, Natália Alvarenga, Reis, Drielly Cristhiny Mendes de Vargas, Silva, Greicielle Santos da, Fonseca, Larissa dos Santos, Ribeiro, Marcia Maria Ferreira, Chermut, Tuany Ramos, Moura, Mariana Camille, Oliveira, Leonardo Capizzani, Paiva, Bruna Regis de, Cardozo, Ludmila Ferreira, Capistrano, Estelina Serrano de Marins, and Mafra, Denise

Published
2024
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12. Coronavirus Disease 2019: Quick Diet and Nutrition Guide for Patients With Chronic Kidney Disease

Author

Mafra, Denise, Cardozo, Ludmila FMF, Moraes, Cristiane, Moreira, Lais SG, Teixeira, Karla TR, Reis, Drielly CMV, Fanton, Susane, Salarolli, Roberta, Kalantar-Zadeh, Kamyar, and Burrowe, Jerrilynn D

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Kidney Disease, Nutrition, Renal and urogenital, COVID-19, Diet, Humans, Renal Insufficiency, Chronic, Clinical Sciences, Urology & Nephrology, Clinical sciences, Nutrition and dietetics
Abstract

Considering the Covid-19 pandemic and that patients with CKD are included in a high-risk group, a quick nutrition guide for patients with CKD in all stages was developed, and it is available in Portuguese at https://bit.ly/2zfSjl0, in English at https://bit.ly/covid19ckd, in Spanish at https://bit.ly/guia enfermedad renal and in French at https://bit.ly/covid19maladierenale.

Published
2021

17. Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Controlled Trial

Author

de Souza Gouveia Moreira, Laís, primary, Resende Teixeira, Karla Thaís, additional, Cardozo, Ludmila F. M. F., additional, Alvarenga, Livia, additional, Regis, Bruna, additional, Sousa de Brito, Jessyca, additional, de Oliveira Leal, Viviane, additional, Borges, Natalia Alvarenga, additional, de Souza da Costa Brum, Isabela, additional, Carraro-Eduardo, José Carlos, additional, Borini, Giovanna B., additional, Berretta, Andresa A., additional, Ribeiro-Alves, Marcelo, additional, and Mafra, Denise, additional

Published
2024
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22. WCN24-1200 Antioxidant effects of a mix containing Curcuma longa L. and green propolis extract on patients undergoing hemodialysis: results from a randomised clinical trial

Author

Nascimento, Danielle, primary, Couto, Heloiza, additional, Britto, Isadora, additional, Alvarenga, Livia, additional, Cardozo, Ludmila, additional, Berretta, Andresa A., additional, Ribeiro-Alves, Marcelo, additional, Delgado, Virgílio Pimentel, additional, Figueiredo da Cunha, Danielle, additional, Teodoro, Anderson J., additional, Almeida, Carolina, additional, Lemos, Isabela, additional, Guimarães Guerra, Mônica Martins, additional, and Mafra, Denise, additional

Published
2024
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32. Can curcumin supplementation break the vicious cycle of inflammation, oxidative stress, and uremia in patients undergoing peritoneal dialysis?

Author

Reis, Drielly C.M.V., primary, Alvarenga, Livia, additional, Cardozo, Ludmila F.M.F., additional, Baptista, Beatriz G., additional, Fanton, Susane, additional, Paiva, Bruna R., additional, Ribeiro-Alves, Marcelo, additional, Fortunato, Rodrigo S., additional, Vasconcelos, Andressa L., additional, Nakao, Lia S., additional, Sanz, Carmen Lucia, additional, Berretta, Andresa A., additional, Leite, Maurilo, additional, and Mafra, Denise, additional

Published
2023
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34. Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2

Author

Pedruzzi, Liliana M, Cardozo, Ludmila FMF, Daleprane, Julio B, Stockler-Pinto, Milena B, Monteiro, Elisa B, Leite, Maurilo, Vaziri, Nosratola D, and Mafra, Denise

Subjects
Kidney Disease, Biotechnology, Genetics, Clinical Research, Bioengineering, 2.1 Biological and endogenous factors, Aetiology, Cardiovascular, Adult, Aged, Biomarkers, Case-Control Studies, Down-Regulation, Female, Humans, Inflammation, Inflammation Mediators, Leukocytes, Mononuclear, Male, Malondialdehyde, Middle Aged, NAD(P)H Dehydrogenase (Quinone), NF-E2-Related Factor 2, NF-kappa B, Oxidative Stress, RNA, Messenger, Renal Dialysis, Renal Insufficiency, Chronic, Tumor Necrosis Factor-alpha, Chronic kidney disease, Nrf2, Oxidative stress, Clinical Sciences, Urology & Nephrology
Abstract

BackgroundOxidative stress and inflammation are common features and the main mediators of progression of chronic kidney disease (CKD) and its cardiovascular complications. Under normal conditions, oxidative stress activates the transcription factor, nuclear factor E2-related factor 2 (Nrf2), which is the master regulator of genes encoding antioxidant and detoxifying enzymes and related proteins. The available data on expression of Nrf2 and its key target gene products in CKD patients is limited. We therefore investigated this topic in a group of CKD patients on hemodialysis.MethodsTwenty adult hemodialysis (HD) patients (aged 54.9 ± 15.2 years) and 11 healthy individuals (aged 50.9 ± 8.0 years) were enrolled. Peripheral blood mononuclear cells (PBMC) were isolated and processed for expression of nuclear factor-κB (NF-κB), Nrf2, heme oxygenase-1 and NADPH: quinoneoxidoreductase 1 (NQO1) by quantitative real-time polymerase chain reaction and western blot analysis. Plasma malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) levels were measured.ResultsPeripheral blood mononuclear cells from HD patients had significantly lower NQO1 and Nrf2 mRNA expressions (0.58 ± 0.35 vs. 1.13 ± 0.64, p = 0.005), and significantly higher NF-κB expression (2.18 ± 0.8 vs. 1.04 ± 0.22, p = 0.0001) compared to the healthy individuals. The NF-κB expression was inversely correlated with Nrf2 levels (r = -0.54, p < 0.01) in CKD patients. Plasma MDA and TNF-α levels were significantly higher in CKD patients than in the healthy individuals.ConclusionsUp-regulation of NFκB in the CKD patients' PBMC is coupled to down-regulation of Nrf2 and NQO1 expression. These observations are consistent with recent findings in CKD animals and point to the contribution of the impaired Nrf2 system in the pathogenesis of oxidative stress and inflammation in hemodialysis patients.

Published
2015

36. Food for healthier aging: power on your plate.

Author

Mafra, Denise, Ugochukwu, Stephanie Ariemu, Borges, Natalia A, Cardozo, Ludmila F. M. F, Stenvinkel, Peter, and Shiels, Paul G.

Subjects
TRANSCRIPTION factors, GUT microbiome, PROTHROMBIN, NF-kappa B, NUCLEAR factor E2 related factor
Abstract

Inflammageing is a persistent low-level inflammatory burden that accompanies age-related dysregulation of the immune system during normative aging and within the diseasome of aging. A healthy diet containing a balanced amount of macronutrients, vitamins and minerals, adequate in calories and rich in poly(phenols), has an essential role in mitigating the effects of inflammageing and extending healthspan through modulation of the activity of a range of factors. These include transcription factors, such as nuclear factor erythroid-derived 2 related factor 2 (Nrf2) and nuclear factor-κB (NF-kB), the inflammasome and the activities of the gut microbiota. The aim of this narrative review is to discuss the potential of food to ameliorate the effects of the diseasome of aging. [ABSTRACT FROM AUTHOR]

Published
2024
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37. The magical smell and taste: Can coffee be good to patients with cardiometabolic disease?

Author

Ribeiro, Marcia, Alvarenga, Livia, Cardozo, Ludmila F. M. F., Kemp, Julie A., Lima, Ligia S., Almeida, Jonatas S. de, Leal, Viviane de O., Stenvinkel, Peter, Shiels, Paul G., and Mafra, Denise

Subjects
COFFEE brewing, HEART metabolism disorders, COFFEE beans, CHRONIC kidney failure, COFFEE, COFFEE plantations, GUT microbiome, SMELL
Abstract

Coffee is a beverage consumed globally. Although few studies have indicated adverse effects, it is typically a beneficial health-promoting agent in a range of diseases, including depression, diabetes, cardiovascular disease, and obesity. Coffee is rich in caffeine, antioxidants, and phenolic compounds, which can modulate the composition of the gut microbiota and mitigate both inflammation and oxidative stress, common features of the burden of lifestyle diseases. This review will discuss the possible benefits of coffee on complications present in patients with diabetes, cardiovascular disease and chronic kidney disease, outwith the social and emotional benefits attributed to caffeine consumption. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Sulforaphane supplementation did not modulate NRF2 and NF-kB mRNA expressions in hemodialysis patients

Author

Ribeiro, Marcia, primary, Cardozo, Ludmila FMF., additional, Paiva, Bruna R., additional, Baptista, Beatriz Germer, additional, Fanton, Susane, additional, Alvarenga, Livia, additional, Lima, Ligia Soares, additional, Kopke, Isadora B., additional, Nakao, Lia S., additional, Fouque, Denis, additional, Ribeiro-Alves, Marcelo, additional, and Mafra, Denise, additional

Published
2023
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46. The effect of Brazilian Green Propolis extract on inflammation in patients with chronic kidney disease on peritoneal dialysis: A randomised double-blind controlled clinical trial

Author

Baptista, Beatriz Germer, primary, Fanton, Susane, additional, Ribeiro, Márcia, additional, Cardozo, Ludmila FMF, additional, Regis, Bruna, additional, Alvarenga, Livia, additional, Ribeiro-Alves, Marcelo, additional, Berretta, Andresa A., additional, Shiels, Paul G., additional, and Mafra, Denise, additional

Published
2023
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49. Cinnamon: an aromatic condiment applicable to chronic kidney disease

Author

Moreira, Laís de Souza Gouveia, primary, Brum, Isabela de Souza da Costa, additional, de Vargas Reis, Drielly C. M., additional, Trugilho, Liana, additional, Chermut, Tuany R., additional, Esgalhado, Marta, additional, Cardozo, Ludmila F. M. F., additional, Stenvinkel, Peter, additional, Shiels, Paul G., additional, and Mafra, Denise, additional

Published
2023
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50. Evaluation of Bach1 mRNA expression in patients with chronic kidney disease: A preliminary study.

Author

Mafra, Denise, Alvarenga, Livia, Ribeiro, Marcia, Baptista, Beatriz G., Fanton, Susane, Paiva, Bruna R., Trugilho, Liana, Kemp, Julie Ann, Alves‐Ribeiro, Marcelo, and Cardozo, Ludmila F. M. F.

Subjects
CHRONIC kidney failure, GENE expression, CHRONICALLY ill, MONONUCLEAR leukocytes, HEME oxygenase
Abstract

Introduction: BTB and CNC homology 1 (Bach1) is a protein that antagonizes some actions of nuclear factor erythroid 2‐related factor‐2 (Nrf2), the master regulator of cytoprotective responses. Bach1 binds to genomic DNA and inhibits the synthesis of antioxidant enzymes, thereby increasing inflammation. Bach1 may be a therapeutic target for mitigating inflammation in chronic kidney disease (CKD) patients. However, no clinical study has been reported on Bach1 in this population. This study aimed to evaluate Bach1 mRNA expression with different treatments for CKD, including conservative treatment (nondialysis), hemodialysis (HD), and peritoneal dialysis (PD). Methods: Twenty patients undergoing HD (56.5 [19] years), 15 on PD (54 [24] years) and 13 nondialysis patients (63 [10] years, with an estimated glomerular filtration rate of 41 [14] mL/min/1.73 m2) were enrolled in the study. The mRNA expression of Nrf2, NF‐kB, heme oxygenase 1 (HO‐1), and Bach1 was evaluated in peripheral blood mononuclear cells using quantitative real‐time polymerase chain reaction. Malondialdehyde (MDA) was evaluated as a lipid peroxidation marker. Routine biochemical parameters were also evaluated. Findings: As expected, patients on dialysis were more inflamed. Bach1 mRNA expression was significantly higher in patients undergoing HD than in PD and nondialysis patients (p < 0.007). The mRNA expression of HO‐1, NF‐kB, and Nrf2 was not different in the groups. Conclusion: In conclusion, CKD patients on HD exhibited an upregulation of Bach1 mRNA expression compared to patients on PD treatment and nondialysis CKD patients. The association between Nrf2 and Bach1 expression in these patients warrants further investigation. [ABSTRACT FROM AUTHOR]

Published
2023
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