14 results on '"Cardoso, Paulo F G"'
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2. Comparison of Three Different Mathematical Models Applied to Respiratory Mechanics During Bronchoconstriction
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Barros, Amanda N., primary, Vitorasso, Renato de L., additional, Valenga, Marcelo H., additional, Aoki, Fabio Gava, additional, Rodrigues, Thiago Guimarães, additional, Cardoso, Paulo F. G., additional, Pazetti, Rogério, additional, and Moriya, Henrique T., additional
- Published
- 2019
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3. A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)
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Criner, Gerard J., primary, Sue, Richard, additional, Wright, Shawn, additional, Dransfield, Mark, additional, Rivas-Perez, Hiram, additional, Wiese, Tanya, additional, Sciurba, Frank C., additional, Shah, Pallav L., additional, Wahidi, Momen M., additional, de Oliveira, Hugo Goulart, additional, Morrissey, Brian, additional, Cardoso, Paulo F. G., additional, Hays, Steven, additional, Majid, Adnan, additional, Pastis, Nicholas, additional, Kopas, Lisa, additional, Vollenweider, Mark, additional, McFadden, P. Michael, additional, Machuzak, Michael, additional, Hsia, David W., additional, Sung, Arthur, additional, Jarad, Nabil, additional, Kornaszewska, Malgorzata, additional, Hazelrigg, Stephen, additional, Krishna, Ganesh, additional, Armstrong, Brian, additional, Shargill, Narinder S., additional, Slebos, Dirk-Jan, additional, Criner, Gerard J., additional, Cordova, Francis, additional, Desai, Parag, additional, Marchetti, Nathaniel, additional, Kim, Victor, additional, Shenoy, Kartik, additional, Travaline, John, additional, Thomas, Jiji, additional, Criner, Lii-Yoong H., additional, Thornburg, Aaron, additional, Thomas, Terry, additional, Bhatt, Surya, additional, Wells, James Michael, additional, Seabron-Harris, Necole, additional, Gauhar, Umair, additional, Despirito, Crissie, additional, Sciurba, Frank, additional, Bon Field, Jessica, additional, Chandra, Divay, additional, Leader, Joseph, additional, Semaan, Roy, additional, Ledezma, Christina, additional, Shah, Pallav, additional, Kemp, Samuel, additional, Garner, Justin, additional, Aboelhassan, Arafa, additional, Srikanthan, Karthi, additional, Tenda, Eric, additional, Abraham, Anita, additional, Sim, Cai, additional, Wahidi, Momen, additional, Mahmood, Kamran, additional, Shofer, Scott, additional, Coles, Kathleen, additional, Oliveira, Guilherme Augusto, additional, Machado, Betina, additional, Benedetto, Igor, additional, Svartman, Fabio, additional, de Macedo Neto, Amarilio, additional, Schreiner, Leonardo, additional, Vieira, Taiane, additional, Yoneda, Ken, additional, Tham, Tina, additional, Tompkins, Daniel, additional, Guerreiro Cardoso, Paulo F., additional, Athanazio, Rodrigo, additional, Nominando, Felipe, additional, Rached, Samia, additional, Cassimiro, Luciana, additional, Seeley, Eric, additional, Shrestha, Pavan, additional, Dincheva, Gabriela R., additional, Alape-Moya, Daniel, additional, Parikh, Mihir, additional, Paton, Alichia, additional, Agnew, Alexis, additional, Strange, Charlie, additional, Beiko, Tatsiana, additional, Woodford, Danielle, additional, Blanton, Mary, additional, Connolly, Timothy, additional, Santacruz, Jose Fernando, additional, Shah, Bhavin, additional, Herrera, Luis, additional, Khan, Rumi, additional, Sernulka, Kristine, additional, Barbers, Richard, additional, Hernandez, Michelle, additional, Almeida, Francisco, additional, Cicenia, Joseph, additional, Gildea, Thomas, additional, Mehta, Atul, additional, Sethi, Sonali, additional, Meli, Yvonne, additional, Hsia, David, additional, Casaburi, Richard, additional, Stringer, William, additional, Diaz, Leticia, additional, Ramsey, Meghan, additional, Van Wert, Ryan, additional, Morris, Karen, additional, Batchelor, Tim, additional, Sequeiros, Iara, additional, Tucker, Katy, additional, Kornaszweska, Malgorzata, additional, Fallouh, Hazem, additional, Sabit, Ramsey, additional, Naase, Hatam, additional, George, Joseph, additional, Salimian, Azin, additional, Dyer, Helen, additional, Adams, Kristal, additional, Bade, Karen, additional, Benn, Bryan S., additional, Canfield, Michelle, additional, Vetri Villalan, Sharmila, additional, Stewart, Travis, additional, ten Hacken, Nick H. T., additional, Klooster, Karin, additional, Hartman, Jorine, additional, and Augustijn, Sonja, additional
- Published
- 2018
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4. Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury
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Yoshida, Takeshi, primary, Amato, Marcelo B. P., additional, Grieco, Domenico Luca, additional, Chen, Lu, additional, Lima, Cristhiano A. S., additional, Roldan, Rollin, additional, Morais, Caio C. A., additional, Gomes, Susimeire, additional, Costa, Eduardo L. V., additional, Cardoso, Paulo F. G., additional, Charbonney, Emmanuel, additional, Richard, Jean-Christophe M., additional, Brochard, Laurent, additional, and Kavanagh, Brian P., additional
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- 2018
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5. Use of MDCT to Assess the Results of Bronchial Thermoplasty
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Zanon, Matheus, primary, Strieder, Débora L., additional, Rubin, Adalberto S., additional, Watte, Guilherme, additional, Marchiori, Edson, additional, Cardoso, Paulo F. G., additional, and Hochhegger, Bruno, additional
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- 2017
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6. Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury.
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Takeshi Yoshida, Amato, Marcelo B. P., Grieco, Domenico Luca, Lu Chen, Lima, Cristhiano A. S., Roldan, Rollin, Morais, Caio C. A., Gomes, Susimeire, Costa, Eduardo L. V., Cardoso, Paulo F. G., Charbonney, Emmanuel, Richard, Jean-Christophe M., Brochard, Laurent, Kavanagh, Brian P., Yoshida, Takeshi, and Chen, Lu
- Abstract
Rationale: Esophageal manometry is the clinically available method to estimate pleural pressure, thus enabling calculation of transpulmonary pressure (Pl). However, many concerns make it uncertain in which lung region esophageal manometry reflects local Pl.Objectives: To determine the accuracy of esophageal pressure (Pes) and in which regions esophageal manometry reflects pleural pressure (Ppl) and Pl; to assess whether lung stress in nondependent regions can be estimated at end-inspiration from Pl.Methods: In lung-injured pigs (n = 6) and human cadavers (n = 3), Pes was measured across a range of positive end-expiratory pressure, together with directly measured Ppl in nondependent and dependent pleural regions. All measurements were obtained with minimal nonstressed volumes in the pleural sensors and esophageal balloons. Expiratory and inspiratory Pl was calculated by subtracting local Ppl or Pes from airway pressure; inspiratory Pl was also estimated by subtracting Ppl (calculated from chest wall and respiratory system elastance) from the airway plateau pressure.Measurements and Main Results: In pigs and human cadavers, expiratory and inspiratory Pl using Pes closely reflected values in dependent to middle lung (adjacent to the esophagus). Inspiratory Pl estimated from elastance ratio reflected the directly measured nondependent values.Conclusions: These data support the use of esophageal manometry in acute respiratory distress syndrome. Assuming correct calibration, expiratory Pl derived from Pes reflects Pl in dependent to middle lung, where atelectasis usually predominates; inspiratory Pl estimated from elastance ratio may indicate the highest level of lung stress in nondependent "baby" lung, where it is vulnerable to ventilator-induced lung injury. [ABSTRACT FROM AUTHOR]- Published
- 2018
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7. Peritoneal Free Autologous Fat Graft for the Control of Pulmonary Air Leaks in Emphysematous Rat Lungs.
- Author
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Andrade, Cristiano F., Fontena, Eduardo, Cardoso, Paulo F. G., Pereira, Raôni B., Grun, Gustavo, Forgiarini, Luiz F., Moreira, José S., and Felicetti, José C.
- Abstract
Background. Persistent pulmonary air leak is the most frequent complication after lung resection, resulting in an increase in postoperative morbidity and mortality. We evaluated the viability, integration, and efficacy of a free peritoneal fat graft as a method for controlling air leak in normal and emphysematous rat lungs. Methods. Sixty Wistar rats were divided into two groups: elastase-produced lung emphysema (n = 30) and control (normal) lungs (n = 30). Pulmonary air leak was produced by puncture of the right lower lobe, and aerostasis was attempted by means of intrapulmonary injection of autologous free peritoneal fat graft. Rats in each group (n = 6) were randomly allocated to subgroups and were sacrificed at 7, 14, 21, 30, and 60 days. Then, lungs were removed for histology, morphometry, vessel identification and counting, and immunohistochemistry for caspase 3, vascular endothelial growth factor, and factor VIII. Results. Tissue integration of the free fat grafts was found in all animals in both groups. Vessels stained with India ink inside the fat grafts were present at all assessment periods in both groups. Vascular endothelial growth factor expression was significantly higher in all periods in the emphysema group compared with normal lungs (p < 0.001). There was a significant increase in caspase 3 expression in the emphysema group at 7, 21, 30, and 60 days (p < 0.001). Factor VIII showed a significant increase (p < 0.001) at 30 and 60 days in emphysematous lungs. Conclusions. The use of free peritoneal fat graft was able to control the air leaks in normal and emphysematous rat lungs, with persisting graft viability for as long as 60 days after implantation. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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8. Design of the exhale airway stents for emphysema (EASE) trial: an endoscopic procedure for reducing hyperinflation.
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Shah, Pallav L., Slebos, Dirk-Jan, Cardoso, Paulo F. G., Cetti, Edward J., Sybrecht, Gerhard W., and Cooper, Joel D.
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MEDICAL research ,CORONARY artery bypass ,RESPIRATORY diseases ,ENDOSCOPIC surgery ,PULMONARY function tests - Abstract
Background: Airway Bypass is a catheter-based, bronchoscopic procedure in which new passageways are created that bypass the collapsed airways, enabling trapped air to exit the lungs. The Exhale Airway Stents for Emphysema (EASE) Trial was designed to investigate whether Exhale® Drug-Eluting Stents, placed in new passageways in the lungs, can improve pulmonary function and reduce breathlessness in severely hyperinflated, homogeneous emphysema patients (NCT00391612). Methods/Design: The multi-center, randomized, double-blind, sham-controlled trial design was posted on http:// www.clinicaltrials.gov in October 2006. Because Bayesian statistics are used for the analysis, the proposed enrollment ranged from 225 up to 450 subjects at up to 45 institutions. Inclusion criteria are: high resolution CT scan with evidence of homogeneous emphysema, post-bronchodilator pulmonary function tests showing: a ratio of FEV
1 /FVC < 70%, FEV1 ≤50% of predicted or FEV1 < 1 liter, RV/TLC≥0.65 at screening, marked dyspnea score ≥2 on the modified Medical Research Council scale of 0-4, a smoking history of at least 20 pack years and stopped smoking for at least 8 weeks prior to enrollment. Following 16 to 20 supervised pulmonary rehabilitation sessions, subjects were randomized 2:1 to receive either a treatment (Exhale® Drug-Eluting Stent) or a sham bronchoscopy. A responder analysis will evaluate the co-primary endpoints of an FVC improvement ≥12% of the patient baseline value and modified Medical Research Council dyspnea scale improvement (reduction) ≥1 point at the 6-month follow-up visit. Discussion: If through the EASE Trial, Airway Bypass is shown to improve pulmonary function and reduce dyspnea while demonstrating an acceptable safety profile, then homogeneous patients will have a minimally invasive treatment option with meaningful clinical benefit. Trial Registration: ClinicalTrials.gov: NCT00391612 [ABSTRACT FROM AUTHOR]- Published
- 2011
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9. LOW-POTASSIUM UW SOLUTION FOR LUNG PRESERVATION
- Author
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OKA, TADAYUKI, primary, PUSKAS, JOHN D., additional, MAYER, ECKHARD, additional, CARDOSO, PAULO F. G., additional, SHI, SHIQING, additional, WISSER, WILFRIED, additional, SLUTSKY, ARTHUR S., additional, and PATTERSON, GEORGE A., additional
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- 1991
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10. LOWPOTASSIUM UW SOLUTION FOR LUNG PRESERVATION
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OKA, TADAYUKI, PUSKAS, JOHN D., MAYER, ECKHARD, CARDOSO, PAULO F. G., SHI, SHIQING, WISSER, WILFRIED, SLUTSKY, ARTHUR S., and PATTERSON, GEORGE A.
- Abstract
University of Wisconsin solution has been used successfully in clinical kidney and liver preservation. The object of this study was to determine if low-potassium UW (LPUW) solution could be applied to pulmonary preservation. Rabbit lungs were stored after hypothermic pulmonary artery (PA) flush with four different solutions (group 1: low-potassium dextran (LPD) solution, group 2: high-potassium UW (HPUW) solution, group 3: LPUW solution, group 4: modified Euro-Collins (E-C) solution). The lungs were preserved at 10°C for 30 hr and evaluated in an ex vivo ventilation/perfusion apparatus using fresh pooled venous rabbit blood. Mean PA flush pressures (MFP) during harvesting were significantly lower in groups 1 and 3 (8.1±1.0 mmHg and 7.3±0.6 mmHg, respectively; mean ± SEM) than in groups 2 and 4 (15.5±1.7 mmHg and 12.3±0.9 mmHg, respectively). Lungs in groups 1 and 3 showed significantly higher PaO2(103.5±8.0 mmHg and 89.3±7.2 mmHg) than groups 2 and 4 (48.3±7.7 mmHg, 66.7±4.7 mmHg). Groups 1 and 3 showed significantly lower wet/ dry weight (W/D) ratios after reperfusion (6.21±0.15 and 6.39±0.23) than groups 2 and 4 (7.70±0.57 and 7.13±0.21, respectively). There were no significant differences in MFP, PaO2, PaCO2, mean pulmonary artery pressure, or W/D ratio between groups 1 and 3. These results suggest that LPUW solution may be as beneficial as LPD solution for pulmonary arterial flush and lung preservation.
- Published
- 1991
11. Nonfunctioning paraganglioma of the aortopulmonary window.
- Author
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Andrade, Cristiano F., Camargo, Spencer M., Zanchet, Marcelo, Felicetti, José C., and Cardoso, Paulo F. G.
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NERVOUS system tumors ,MEDIASTINUM ,CARDIOPULMONARY bypass ,SURGICAL excision - Abstract
Aortopulmonary paraganglioma is a rare tumor of the mediastinum. The only effective treatment is complete resection, which may pose a surgical challenge because of its proximity to the heart, great vessels, and trachea, often rendering a complete resection difficult to achieve. We report a case in which the tumor was excised under cardiopulmonary bypass and resulted in massive bleeding only controlled by means of packing the pleural cavity during 48 hours, known as damage control strategy. The patient survived and has been disease-free for 2 years. [Copyright &y& Elsevier]
- Published
- 2003
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12. Use of MDCT to Assess the Results of Bronchial Thermoplasty.
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Zanon M, Strieder DL, Rubin AS, Watte G, Marchiori E, Cardoso PFG, and Hochhegger B
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- Adult, Female, Humans, Male, Middle Aged, Pulmonary Surgical Procedures methods, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Ablation Techniques, Asthma drug therapy, Asthma surgery, Bronchi diagnostic imaging, Bronchi surgery, Tomography, X-Ray Computed
- Abstract
Objective: The purpose of this study was to evaluate the use of MDCT to assess response to bronchial thermoplasty treatment for severe persistent asthma., Materials and Methods: MDCT data from 26 patients with severe persistent asthma who underwent imaging before and after bronchial thermoplasty were analyzed retrospectively. Changes in the following parameters were assessed: total lung volume, mean lung density, airway wall thickness, CT air trapping index (attenuation < -856 HU), and expiratory-inspiratory ratio of mean lung density (E/I index). Asthma Quality of Life Questionnaire score changes were also assessed., Results: Median total lung volumes before and after bronchial thermoplasty were 2668 mL (range, 2226-3096 mL) and 2399 mL (range, 1964-2802 mL; p = 0.08), respectively. Patients also showed a pattern of obstruction improvement in air trapping values (median before thermoplasty, 14.25%; median after thermoplasty, 3.65%; p < 0.001] and in mean lung density values ± SD (before thermoplasty, -702 ± 72 HU; after thermoplasty, -655 ± 66 HU; p < 0.01). Median airway wall thickness also decreased after bronchial thermoplasty (before thermoplasty, 1.5 mm; after thermoplasty, 1.1 mm; p < 0.05). There was a mean Asthma Quality of Life Questionnaire overall score change of 1.00 ± 1.35 (p < 0.001), indicating asthma clinical improvement., Conclusion: Our study showed improvement in CT measurements after bronchial thermoplasty, along with Asthma Quality of Life Questionnaire score changes. Thus, MDCT could be useful for imaging evaluation of patients undergoing this treatment.
- Published
- 2017
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13. Airway bypass treatment of severe homogeneous emphysema: taking advantage of collateral ventilation.
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Choong CK, Cardoso PF, Sybrecht GW, and Cooper JD
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- Humans, Pulmonary Emphysema physiopathology, Pulmonary Ventilation physiology, Research Design, Bronchi surgery, Drug-Eluting Stents, Pulmonary Emphysema surgery
- Abstract
Airway bypass is being investigated as a new form of minimally invasive therapy for the treatment of homogeneous emphysema. It is a bronchoscopic catheter-based procedure that creates transbronchial extra-anatomic passages at the bronchial segmental level. The passages are expanded, supported with the expectation that the patency is maintained by paclitaxel drug-eluting airway bypass stents. The concept of airway bypass has been demonstrated in two separate experimental studies. These studies have shown that airway bypass takes advantage of collateral ventilation present in homogeneous emphysema to allow trapped gas to escape and reduce hyperinflation. It improves lung mechanics, expiratory flow, and volume. Airway bypass stent placements have been shown to be feasible and safe in both animal and human studies. Paclitaxel-eluting airway bypass stents were found to prolong stent patency and were adopted for clinical studies. A study evaluating the early results of the clinical application of airway bypass with paclitaxel-eluting stents found that airway bypass procedures reduced hyperinflation and improved pulmonary function and dyspnea in selected subjects who have severe emphysema. The duration of benefit appeared to correlate with the degree of pretreatment hyperinflation. These preliminary clinical results supported further evaluation of the procedure and led to the EASE Trial. The EASE Trial is a prospective, multicenter, randomized, double-blind, sham-controlled study. The trial aims to evaluate the safety and effectiveness of the airway bypass to improve pulmonary function and reduce dyspnea in homogeneous emphysema subjects who have severe hyperinflation. The trial is presently ongoing worldwide, though enrollment was completed.
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- 2009
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14. Clinical application of airway bypass with paclitaxel-eluting stents: early results.
- Author
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Cardoso PF, Snell GI, Hopkins P, Sybrecht GW, Stamatis G, Ng AW, and Eng P
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- Aged, Aged, 80 and over, Bronchoscopy, Equipment Design, Female, Fiber Optic Technology, Humans, Male, Middle Aged, Patient Selection, Postoperative Complications, Pulmonary Emphysema physiopathology, Respiratory Function Tests, Retrospective Studies, Surveys and Questionnaires, Treatment Outcome, Drug Delivery Systems, Paclitaxel administration & dosage, Pulmonary Emphysema surgery, Stents
- Abstract
Objective: To assess the safety and early clinical results of a multicenter evaluation of airway bypass with paclitaxel-eluting stents for selected patients with severe emphysema., Methods: Airway bypass was performed with a fiberoptic bronchoscope in three steps: identification of a blood vessel-free location with a Doppler probe at the level of segmental bronchi, fenestration of the bronchial wall, and placement of a paclitaxel-eluting stent to expand and maintain the new passage between the airway and adjacent lung tissue. All adverse events were recorded, as well as 1- and 6-month pulmonary function tests and dyspnea index., Results: Thirty-five patients received the airway bypass procedure with a median of 8 stents implanted per patient. At 1-month follow-up, statistically significant differences in residual volume, total lung capacity, forced vital capacity, forced expiratory volume, modified Medical Research Council scale, 6-minute walk, and St George's Respiratory Questionnaire were observed. At the 6-month follow-up, statistically significant improvements in residual volume and dyspnea were demonstrated. One death occurred after bleeding during the procedure. Retrospective analysis revealed that the degree of pretreatment hyperinflation may be an important indicator of which patients achieve the best short- and long-term results., Conclusions: The airway bypass procedure reduces hyperinflation and improves pulmonary function and dyspnea in selected patients with severe emphysema. Duration of benefit appears to correlate with the degree of pretreatment hyperinflation. These preliminary clinical results support further evaluation of the procedure.
- Published
- 2007
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