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47 results on '"Cardoso, Claudia R.L."'

33. Prognostic Effect of the Nocturnal Blood Pressure Fall in Hypertensive Patients

Author

Salles, Gil F., primary, Reboldi, Gianpaolo, additional, Fagard, Robert H., additional, Cardoso, Claudia R.L., additional, Pierdomenico, Sante D., additional, Verdecchia, Paolo, additional, Eguchi, Kazuo, additional, Kario, Kazuomi, additional, Hoshide, Satoshi, additional, Polonia, Jorge, additional, de la Sierra, Alejandro, additional, Hermida, Ramon C., additional, Dolan, Eamon, additional, O’Brien, Eoin, additional, and Roush, George C., additional

Published
2016
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35. Effects of Continuous Positive Airway Pressure Treatment on Clinic and Ambulatory Blood Pressures in Patients With Obstructive Sleep Apnea and Resistant Hypertension

Author

Muxfeldt, Elizabeth S., primary, Margallo, Victor, additional, Costa, Leonardo M.S., additional, Guimarães, Gleison, additional, Cavalcante, Aline H., additional, Azevedo, João C.M., additional, de Souza, Fabio, additional, Cardoso, Claudia R.L., additional, and Salles, Gil F., additional

Published
2015
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46. Prognostic Significance of Baseline Heart Rate and Its Interaction With Beta-Blocker Use in Resistant Hypertension: A Cohort Study.

Author

Salles, Gil F., Cardoso, Claudia R.L., Fonseca, Luciane L., Fiszman, Roberto, and Muxfeldt, Elizabeth S.

Subjects
HEART beat, ADRENERGIC beta blockers, HYPERTENSION, BLOOD pressure, ELECTROCARDIOGRAPHY, COHORT analysis
Abstract

BACKGROUND The prognostic significance of heart rate (HR) and its relationship with beta-blocker use are controversial and have never been evaluated in resistant hypertension. METHODS In a prospective study, 528 patients with resistant hypertension had HR measured on clinical examination, electrocardiography (ECG), and during ambulatory blood pressure monitoring. Primary endpoints were a composite of fatal and nonfatal cardiovascular events, all-cause and cardiovascular mortality. Multivariable Cox regression was used to assess the associations between slow HR (< 60 bpm or < 55 bpm for nighttime HR) and fast HR (> 75 bpm or > 70 bpm for nighttime HR) and the occurrence of endpoints in relation to the reference middle HR (60–75 bpm) subgroup. RESULTS After a median follow-up of 4.8 years, 62 patients died, 44 from cardiovascular causes; and 94 cardiovascular events occurred. Fast and slow HRs were mainly predictors of mortality, and ambulatory HRs were more significant risk markers than clinic or ECG HR. A slow 24-hour HR was a predictor of the composite endpoint (hazard ratio, 2.0; 95% confidence interval [CI], 1.2–3.4), whereas both slow and fast ambulatory HRs were predictors of cardiovascular mortality (hazard ratio, 2.3; 95% CI, 1.1–5.1). Four hundred and seventeen patients (79%) were using beta-blockers and this affected the HR prognostic value. A fast HR was a more significant risk marker in patients using beta-blockers, whereas a slow HR was a predictor mainly in those not using beta-blockers. CONCLUSIONS There is an overall U-shaped relationship between HRs, particularly when measured during ambulatory monitoring, and prognosis in resistant hypertension. A fast HR is a significant predictor in patients using beta-blockers, while a slow heart rate is a more important predictor in those not using beta-blockers. [ABSTRACT FROM PUBLISHER]

Published
2013
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47. Thresholds of Ambulatory Blood Pressure Associated With Chronic Complications in Type 2 Diabetes.

Author

Cardoso, Claudia R.L., Leite, Nathalie C., Muxfeldt, Elizabeth S., and Salles, Gil F.

Subjects
AMBULATORY blood pressure monitoring, MEDICAL research, TYPE 2 diabetes complications, MICROCIRCULATION disorders, CROSS-sectional method, KIDNEY diseases
Abstract

BackgroundDiagnostic cut-off values for ambulatory blood pressure monitoring (ABPM) in diabetic patients are not established. The aim was to investigate associations between office and ambulatory blood pressures (BPs) and diabetic chronic complications and to establish optimal threshold ambulatory BP values regarding the likehood of having microvascular complications in type 2 diabetes.MethodsIn a cross-sectional design, clinical, laboratory, and 24-h ABPM data were obtained in 550 type 2 diabetic patients. Multivariate logistic regression assessed the associations between office and ambulatory BPs and diabetic micro and macrovascular complications. Optimal threshold values for ambulatory BPs (daytime, night-time, and 24 h) were established by examining the best combination of systolic (SBP) and diastolic BP (DBP) that maximized the odds ratios (ORs) of having each microvascular complication.ResultsAfter multivariate adjustment for all potential confounders, ambulatory SBPs were more strongly associated with diabetic complications than office BPs, except for retinopathy and nephropathy, in which both were equivalent. In general, night-time BPs were stronger correlates than daytime BPs. The optimal threshold ambulatory BP values were 125/75 mm Hg for daytime, 110/65 mm Hg for night-time, and 120/75 mm Hg for the 24-h period, with odds ranging from 1.7- to 2.3-fold of having each microvascular complication.ConclusionsExcept for retinopathy and advanced nephropathy, ambulatory BPs are better correlates of chronic complications than office BPs in type 2 diabetes. The association of microvascular complications with lower ambulatory BP levels than those reported as normal for nondiabetic patients may indicate that lower cut-off values for ambulatory BPs might be considered in type 2 diabetic patients.American Journal of Hypertension (2012). doi:10.1038/ajh.2011.168 [ABSTRACT FROM AUTHOR]

Published
2012
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