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33. Immunotherapy with acute leukemia cells modified into antigen-presenting cells: ex vivo culture and gene transfer methods.

Author

Stripecke, R., Levine, A.M., Pullarkat, V., and Cardoso, A.A.

Subjects
ACUTE leukemia, CANCER prognosis, IMMUNE system, CANCER cells
Abstract

Adult patients with acute leukemia have, in general, a poor prognosis, with long-term, disease-free survival achieved in only approximately one-third of cases. One of the proposed mechanisms for this poor overall response is the inability of the immune system to detect and eliminate residual malignant leukemia cells, which subsequently serve as a source of leukemic relapse. This review discusses the rationale of immunotherapy for acute leukemia and presents in vitro and in vivo model systems that were devised for pre-B acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). New advances in the ex vivo manipulation of acute leukemia cells are presented, which attempt to modify these cells into functional antigen-presenting cells. These ceils can then be used as autologous vaccines at the time of minimal residual disease after standard chemotherapy, to stimulate host immune responses against their own leukemia cells. The various approaches toward this aim include incubation of leukemia ceils with cytokines or growth factors and gene manipulation of these cells. In particular, ex vivo culture of ALL cells with CD40 ligand, incubation of AML cells with granulocyte-macrophage colony-stimulating factor and interleukin-4 (GM-CSF/IL4) and lentiviral transduction of ALL and AML cells for expression of immunomodulators (CD80 and GM-CSF) are current approaches under investigation for the development of autoiogous acute leukemia cell vaccines. [ABSTRACT FROM AUTHOR]

Published
2002
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34. In Vitro Effect of Plant Leaf Extracts on Mycelial Growth and Sclerotial Germination of Sclerotium cepivorum.

Author

Pinto, C.M.F., Maffia, L.A., Casali, V.W.D., and Cardoso, A.A.

Subjects
EXTRACTS, SCLEROTIUM cepivorum
Abstract

Examines the effects of plant leaf extracts on mycelial growth and sclerotial germination of Sclerotium cepivorum. Lack of effects from leaf water extracts on the growth and germination; Inhibitory effects of acetone-water leaf extracts; Usefulness of the leaf water extracts of E. citriodora for the control of garlic white rot.

Published
1998
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