118 results on '"Cardona, Daniela"'
Search Results
2. Antibiotic therapy by intrathecal or intraventricular approach for postsurgical meningitis or ventriculitis: a systematic review and meta-analysis
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Florez-Perdomo, William A., Escobar-Cardona, Daniela, Janjua, Tariq, Agrawal, Amit, Vasquez, Harold, Lozada-Martinez, Iván David, and Moscote-Salazar, Luis Rafael
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- 2023
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3. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
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Beck, David, Ferrada, Marcela, Sikora, Keith, Ombrello, Amanda, Collins, Jason, Pei, Wuhong, Balanda, Nicholas, Ross, Daron, Ospina Cardona, Daniela, Wu, Zhijie, Patel, Bhavisha, Manthiram, Kalpana, Groarke, Emma, Gutierrez-Rodrigues, Fernanda, Hoffmann, Patrycja, Rosenzweig, Sofia, Nakabo, Shuichiro, Dillon, Laura, Hourigan, Christopher, Tsai, Wanxia, Gupta, Sarthak, Carmona-Rivera, Carmelo, Asmar, Anthony, Xu, Lisha, Oda, Hirotsugu, Goodspeed, Wendy, Barron, Karyl, Nehrebecky, Michele, Jones, Anne, Laird, Ryan, Deuitch, Natalie, Rowczenio, Dorota, Rominger, Emily, Wells, Kristina, Lee, Chyi-Chia, Wang, Weixin, Trick, Megan, Mullikin, James, Wigerblad, Gustaf, Brooks, Stephen, DellOrso, Stefania, Deng, Zuoming, Chae, Jae, Dulau-Florea, Alina, Malicdan, May, Novacic, Danica, Colbert, Robert, Kaplan, Mariana, Gadina, Massimo, Savic, Sinisa, Lachmann, Helen, Abu-Asab, Mones, Solomon, Benjamin, Retterer, Kyle, Gahl, William, Burgess, Shawn, Aksentijevich, Ivona, Young, Neal, Calvo, Katherine, Werner, Achim, Kastner, Daniel, and Grayson, Peter
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Age of Onset ,Aged ,Aged ,80 and over ,Autoimmune Diseases ,Cytokines ,Exome ,Genetic Diseases ,X-Linked ,Genotype ,Giant Cell Arteritis ,Humans ,Immunoblotting ,Inflammation ,Male ,Middle Aged ,Multiple Myeloma ,Mutation ,Missense ,Myelodysplastic Syndromes ,Polyarteritis Nodosa ,Polychondritis ,Relapsing ,Sequence Analysis ,DNA ,Sweet Syndrome ,Syndrome ,Ubiquitin-Activating Enzymes - Abstract
BACKGROUND: Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may define new disorders. METHODS: We analyzed peripheral-blood exome sequence data independent of clinical phenotype and inheritance pattern to identify deleterious mutations in ubiquitin-related genes. Sanger sequencing, immunoblotting, immunohistochemical testing, flow cytometry, and transcriptome and cytokine profiling were performed. CRISPR-Cas9-edited zebrafish were used as an in vivo model to assess gene function. RESULTS: We identified 25 men with somatic mutations affecting methionine-41 (p.Met41) in UBA1, the major E1 enzyme that initiates ubiquitylation. (The gene UBA1 lies on the X chromosome.) In such patients, an often fatal, treatment-refractory inflammatory syndrome develops in late adulthood, with fevers, cytopenias, characteristic vacuoles in myeloid and erythroid precursor cells, dysplastic bone marrow, neutrophilic cutaneous and pulmonary inflammation, chondritis, and vasculitis. Most of these 25 patients met clinical criteria for an inflammatory syndrome (relapsing polychondritis, Sweets syndrome, polyarteritis nodosa, or giant-cell arteritis) or a hematologic condition (myelodysplastic syndrome or multiple myeloma) or both. Mutations were found in more than half the hematopoietic stem cells, including peripheral-blood myeloid cells but not lymphocytes or fibroblasts. Mutations affecting p.Met41 resulted in loss of the canonical cytoplasmic isoform of UBA1 and in expression of a novel, catalytically impaired isoform initiated at p.Met67. Mutant peripheral-blood cells showed decreased ubiquitylation and activated innate immune pathways. Knockout of the cytoplasmic UBA1 isoform homologue in zebrafish caused systemic inflammation. CONCLUSIONS: Using a genotype-driven approach, we identified a disorder that connects seemingly unrelated adult-onset inflammatory syndromes. We named this disorder the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. (Funded by the NIH Intramural Research Programs and the EU Horizon 2020 Research and Innovation Program.).
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- 2020
4. Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis
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Ferrada, Marcela A., Savic, Sinisa, Cardona, Daniela Ospina, Collins, Jason C., Alessi, Hugh, Gutierrez-Rodrigues, Fernanda, Kumar, Dinesh Babu Uthaya, Wilson, Lorena, Goodspeed, Wendy, Topilow, James S., Paik, Julie J., Poulter, James A., Kermani, Tanaz A., Koster, Matthew J., Warrington, Kenneth J., Cargo, Catherine, Tattersall, Rachel S., Duncan, Christopher J.A., Cantor, Anna, Hoffmann, Patrycja, Payne, Elspeth M., Bonnekoh, Hanna, Krause, Karoline, Cowen, Edward W., Calvo, Katherine R., Patel, Bhavisha A., Ombrello, Amanda K., Kastner, Daniel L., Young, Neal S., Werner, Achim, Grayson, Peter C., and Beck, David B.
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- 2022
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5. Molecular detection of viruses infecting purple passion fruit (Passiflora edulis f. edulis) crops, plantlets and seeds from Eastern Antioquia (Colombia)/DETECCION MOLECULAR DE VIRUS EN CULTIVOS, PLANTULAS Y SEMILLAS DE GULUPA (Passiflora edulis f. edulis) EN EL ORIENTE DE ANTIOQUIA
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Cardona, Daniela, Garcia, Yuliana Gallo, Higuita, Monica, Sanchez, Rodrigo Hoyos, Sanchez, Pablo A. Gutierrez, and Montoya, Mauricio Marin
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- 2022
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6. Clinical Heterogeneity of the VEXAS Syndrome: A Case Series
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Koster, Matthew J., Kourelis, Taxiarchis, Reichard, Kaaren K., Kermani, Tanaz A., Beck, David B., Cardona, Daniela Ospina, Samec, Matthew J., Mangaonkar, Abhishek A., Begna, Kebede H., Hook, C. Christopher, Oliveira, Jennifer L., Nasr, Samih H., Tiong, Benedict K., Patnaik, Mrinal M., Burke, Michelle M., Michet, Clement J., Jr., and Warrington, Kenneth J.
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- 2021
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7. Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1
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Obiorah, Ifeyinwa Emmanuela, Patel, Bhavisha A., Groarke, Emma M., Wang, Weixin, Trick, Megan, Ombrello, Amanda K., Ferrada, Marcela A., Wu, Zhijie, Gutierrez-Rodrigues, Fernanda, Lotter, Jennifer, Wilson, Lorena, Hoffmann, Patrycja, Cardona, Daniela Ospina, Patel, Nisha, Dulau-Florea, Alina, Kastner, Daniel L., Grayson, Peter C., Beck, David B., Young, Neal S., and Calvo, Katherine R.
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- 2021
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8. Description of a novel splice site variant in UBA1 gene causing VEXAS syndrome.
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Cardona, Daniela Ospina, Rodriguez-Pinto, Ignasi, Iosim, Sonia, Bonet, Nuria, Mensa-Vilaro, Anna, Wong, Mei-Kay, Ho, Gary, Tormo, Marc, Yagüe, Jordi, Shon, Wonwoo, Wallace, Daniel J, Casals, Ferran, Beck, David B, Abuav, Rachel, and Arostegui, Juan I
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SWEET'S syndrome , *GENOMICS , *RESEARCH funding , *AUTOINFLAMMATORY diseases , *ENZYMES , *FEVER , *GENETIC variation , *RNA , *MESSENGER RNA , *NUCLEOTIDES , *AGE factors in disease , *X-linked genetic disorders , *GENETIC mutation , *DISEASE relapse , *INFLAMMATION , *GENETIC testing , *MOSAICISM , *SYMPTOMS - Abstract
Objective Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a complex immune disorder consequence of somatic UBA1 variants. Most reported pathogenic UBA1 variants are missense or splice site mutations directly impairing the translational start site at p.Met41, with recent studies showing that these variants are frequent causes of recurrent inflammation in older individuals. Here we aimed to characterize a novel UBA1 variant found in two patients clinically presenting with VEXAS syndrome. Methods Patients' data were collected from direct assessments and from their medical charts. Genomics analyses were undertaken by both Sanger and amplicon-based deep sequencing, and mRNA studies were undertaken by both cDNA subcloning and mRNA sequencing. Results We report a novel, somatic variant in a canonical splice site of the UBA1 gene (c.346-2A>G), which was identified in two unrelated adult male patients with late-onset, unexplained inflammatory manifestations including recurrent fever, Sweet syndrome-like neutrophilic dermatosis, and lung inflammation responsive only to glucocorticoids. RNA analysis of the patients' samples indicated aberrant mRNA splicing leading to multiple in-frame transcripts, including a transcript retaining the full sequence of intron 4 and a different transcript with the deletion of the first 15 nucleotides of exon 5. Conclusion Here we describe abnormal UBA1 transcription as a consequence of the novel c.346-2A>G variant, identified in two patients with clinical features compatible with VEXAS syndrome. Overall, these results further demonstrate the expanding spectrum of variants in UBA1 leading to pathology and provide support for a complete gene evaluation in those patients considered candidates for VEXAS syndrome. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Description of a novel splice site variant in UBA1 gene causing VEXAS syndrome
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Ospina Cardona, Daniela, primary, Rodriguez-Pinto, Ignasi, additional, Iosim, Sonia, additional, Bonet, Nuria, additional, Mensa-Vilaro, Anna, additional, Wong, Mei-Kay, additional, Ho, Gary, additional, Tormo, Marc, additional, Yagüe, Jordi, additional, Shon, Wonwoo, additional, Wallace, Daniel, additional, Casals, Ferran, additional, Beck, David B, additional, Abuav, Rachel, additional, and Arostegui, Juan I, additional
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- 2024
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10. Prevalencia de asma y factores relacionados en niños de 6 a 12 años en una comunidad de Pereira, Colombia.
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Milena Bermúdez-Martínez, Mónica, Paulina Castrillón-Correa, Laura, Mauricio Obando-Cardona, Diego, Escobar-Cardona, Daniela, María Esquivia-Peñaloza, Eva, Gutiérrez-Soleibe, Samuel, and Gaviria-Mendoza, Andrés
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LATIN Americans ,CONVENIENCE sampling (Statistics) ,FAMILY history (Medicine) ,ASTHMA in children ,ASTHMA - Abstract
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- 2024
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11. Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS
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Wu, Zhijie, primary, Gao, Shouguo, additional, Gao, Qingyan, additional, Patel, Bhavisha A., additional, Groarke, Emma M., additional, Feng, Xingmin, additional, Manley, Ash Lee, additional, Li, Haoran, additional, Ospina Cardona, Daniela, additional, Kajigaya, Sachiko, additional, Alemu, Lemlem, additional, Quinones Raffo, Diego, additional, Ombrello, Amanda K., additional, Ferrada, Marcela A., additional, Grayson, Peter C., additional, Calvo, Katherine R., additional, Kastner, Daniel L., additional, Beck, David B., additional, and Young, Neal S., additional
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- 2023
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12. Desactivación agraria por fenómenos naturales, estudio de caso vereda Santa Rita, Santa Rosa de Cabal, Risaralda
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Zuñiga Torres, María Constanza, Cardona Cardona , Daniela, Zuñiga Torres, María Constanza, and Cardona Cardona , Daniela
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Debido a la vulnerabilidad que presentan las zonas rurales del país a ser afectadas por fenómenos naturales, y posteriormente a sufrir desactivación de las zonas agrarias, se formuló una metodología que permita estimar las pérdidas no agrícolas ocasionadas por la ocurrencia de dichos fenómenos. Esta investigación se llevó a cabo en la vereda Santa Rita del municipio de Santa Rosa de Cabal, Risaralda, zona veredal que fue afectada por una creciente que presentó el río Campoalegre el pasado 14 de marzo del año 2019, a partir de entrevistas semiestructuradas y observación participante, se logró determinar que 11 sistemas fincas fueron afectados de forma directa y 32 de forma indirecta, adicionalmente se estimaron las pérdidas no agrícolas y agrícolas ocasionadas por dicho fenómeno natural, y finalmente a través de la gestión ambiental local se construyeron lineamientos de acción que contribuyan a mejorar la gestión de esta comunidad., Due to the vulnerability of rural areas of the country to being affected by natural phenomena, and later to suffer the deactivation of agricultural areas, a methodology was built to estimate non-agricultural losses caused by the occurrence of such phenomena. This research was carried out in the village of Santa Rita in the municipality of Santa Rosa de Cabal, Risaralda, a village area that was affected by a flood that the Campoalegre river presented on March 14, 2019, based on semi-structured interviews and observation. participant, it will be determined that 11 farm systems were affected directly and 32 indirectly, additionally the non-agricultural and agricultural losses caused by said natural phenomenon were estimated, and finally through local environmental management action guidelines were built that Contribute to improve the management of this community.
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- 2023
13. Desactivación agraria por fenómenos naturales, estudio de caso vereda Santa Rita, Santa Rosa de Cabal, Risaralda
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Cardona Cardona , Daniela and Zuñiga Torres, María Constanza
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Desarrollo rural ,Sostenibilidad agricola ,Desactivación rural ,Estudios de caso ,Sistemas - Fincas ,Fenómenos naturales ,630 - Agricultura y tecnologías relacionadas - Abstract
Debido a la vulnerabilidad que presentan las zonas rurales del país a ser afectadas por fenómenos naturales, y posteriormente a sufrir desactivación de las zonas agrarias, se formuló una metodología que permita estimar las pérdidas no agrícolas ocasionadas por la ocurrencia de dichos fenómenos. Esta investigación se llevó a cabo en la vereda Santa Rita del municipio de Santa Rosa de Cabal, Risaralda, zona veredal que fue afectada por una creciente que presentó el río Campoalegre el pasado 14 de marzo del año 2019, a partir de entrevistas semiestructuradas y observación participante, se logró determinar que 11 sistemas fincas fueron afectados de forma directa y 32 de forma indirecta, adicionalmente se estimaron las pérdidas no agrícolas y agrícolas ocasionadas por dicho fenómeno natural, y finalmente a través de la gestión ambiental local se construyeron lineamientos de acción que contribuyan a mejorar la gestión de esta comunidad. Due to the vulnerability of rural areas of the country to being affected by natural phenomena, and later to suffer the deactivation of agricultural areas, a methodology was built to estimate non-agricultural losses caused by the occurrence of such phenomena. This research was carried out in the village of Santa Rita in the municipality of Santa Rosa de Cabal, Risaralda, a village area that was affected by a flood that the Campoalegre river presented on March 14, 2019, based on semi-structured interviews and observation. participant, it will be determined that 11 farm systems were affected directly and 32 indirectly, additionally the non-agricultural and agricultural losses caused by said natural phenomenon were estimated, and finally through local environmental management action guidelines were built that Contribute to improve the management of this community. Pregrado Administrador(a) Ambiental TABLA DE CONTENIDO DEDICATORIA..................................................................................................................... 4 AGRADECIMIENTOS.......................................................................................................... 5 RESUMEN........................................................................................................................... 10 ABSTRACT ......................................................................................................................... 10 1. INTRODUCCIÓN ........................................................................................................ 11 2. OBJETIVOS.................................................................................................................. 14 2.1 Objetivo General......................................................................................................... 14 2.2 Objetivos Específicos ................................................................................................. 14 3. REFERENTE TEÓRICO.............................................................................................. 15 3.1 Afectación de los sistemas fincas por los fenómenos naturales ............................ 15 3.2 Efecto del desbordamiento de ríos en Colombia ........................................................ 16 3.3 Planeación territorial para la reducción de riesgos de desactivación de sistemas fincas .......................................................................................................................................... 16 4. METODOLOGÍA ......................................................................................................... 18 4.1 Área de estudio ........................................................................................................... 18 4.2 Método ........................................................................................................................ 19 4.2.1 Caracterización de los sistemas fincas afectados en la vereda Santa Rita por el desbordamiento del río Campoalegre............................................................................ 19 4.2.2 Evaluación del efecto del desbordamiento del río Campoalegre en cuanto a la desactivación de los sistemas fincas de la vereda Santa Rita:....................................... 21 4.2.3 Formulación de un plan de gestión local para la mitigación del riesgo de desactivación de los sistemas fincas de la vereda Santa Rita:....................................... 23 4.3 Análisis de la información .......................................................................................... 24 5. RESULTADOS............................................................................................................. 25 5.1 Caracterización de los sistemas fincas afectados en la vereda Santa Rita por el desbordamiento del río Campoalegre: .............................................................................. 25 5.1.1 Estructura familiar................................................................................................ 25 5.1.2 Sistema productivo:.............................................................................................. 25 5.1.3 Áreas en conservación:......................................................................................... 26 5.1.4 Ingresos: ............................................................................................................... 27 5.1.5 Tiempo de ocupación del territorio:..................................................................... 27 5.1.6 Tipo de ocupación del territorio:.......................................................................... 28 5.1.7 Tipología de la vivienda:...................................................................................... 28 5.1.8 Mano de obra:....................................................................................................... 29 5.2 Evaluación del efecto del desbordamiento del río Campoalegre en cuanto a la desactivación de los sistemas fincas de la vereda Santa Rita: .......................................... 30 5.2.1 Indicadores de población:..................................................................................... 30 5.2.2 Indicadores de resultados económicos:................................................................ 32 5.2.3 Indicadores de bienestar social y equidad ............................................................ 34 5.2.4 Indicadores de medio ambiente............................................................................ 35 5.2.5 Indicadores de la influencia de los actores económicos, sociales e institucionales internos y externos en la recuperación .......................................................................... 36 5.3 Formulación del plan de gestión local para la mitigación del riesgo de desactivación de los sistemas fincas de la vereda Santa Rita:................................................................. 38 6. DISCUSIÓN DE RESULTADOS ................................................................................ 42 6.1 Caracterización de los sistemas fincas afectados en la vereda Santa Rita por el desbordamiento del río Campoalegre ............................................................................... 42 6.2 Evaluación del efecto del desbordamiento del río Campoalegre en cuanto a la desactivación de los sistemas fincas de la vereda Santa Rita ........................................... 43 6.3 Formulación de un plan de gestión local para la mitigación del riesgo de desactivación de los sistemas fincas de la vereda Santa Rita ........................................... 45 7. CONCLUSIONES ........................................................................................................ 46 8. BIBLIOGRAFÍA........................................................................................................... 48
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- 2023
14. Post ruptivos: De la experiencia de lectura a la creación de contenidos digitales
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Rivera Cardona, Daniela, primary and Lara Lara, Natalia, additional
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- 2022
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15. Novel Disease-Causing Mutations in UBA1 Reveal Disease Mechanisms in Bone Marrow Failure and Inflammation
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Collins, Jason C, primary, Balanda, Nicholas, additional, Magaziner, Samuel J, additional, English, Maya, additional, Ospina Cardona, Daniela, additional, Patnaik, Mrinal M., additional, Terrier, Benjamin, additional, Kosmider, Olivier, additional, Werner, Achim, additional, and Beck, David B., additional
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- 2022
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16. Viruses infecting purple passion fruit (Passiflora edulis f. edulis) in southwestern Antioquia, Colombia
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Cardona, Daniela, primary, Higuita, Mónica, additional, Posada, Jaime, additional, Gallo, Yuliana, additional, Marín, Mauricio, additional, and Gutiérrez, Pablo, additional
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- 2022
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17. Novel genetic mutation in myositis-variant of VEXAS syndrome
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Topilow, James S, primary, Ospina Cardona, Daniela, additional, Beck, David B, additional, Ferrada, Marcela A, additional, McMahan, Zsuzsanna H, additional, and Paik, Julie J, additional
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- 2022
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18. Detección molecular de virus en cultivos, plántulas y semillas de gulupa (passiflora edulis f. Edulis) en el oriente de antioquia
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Cardona, Daniela, Gallo García, Yuliana, Higuita, Mónica, Hoyos Sánchez, Rodrigo, Gutiérrez-Sánchez, Pablo, Marín Montoya, Mauricio Alejandro, Cardona, Daniela, Gallo García, Yuliana, Higuita, Mónica, Hoyos Sánchez, Rodrigo, Gutiérrez-Sánchez, Pablo, and Marín Montoya, Mauricio Alejandro
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Gulupa (Passiflora edulis f. edulis) is among the crops with the largest expansion rates in Antioquia (Colombia). This rapid increase has been accompanied by a rise in prevalence of vascular wilt (Fusarium oxysporum) and viral diseases. In this work, we evaluated the prevalence of four RNA viruses (SMV, CABMV, PFYMV and CMV), in addition to viruses from the genus Begomovirus and the badnavirus GBVA. The presence of viruses was investigated in 15 samples of plantlets and 15 of sexual seeds, 15 asymptomatic and 15 symptomatic, from crops from Eastern Antioquia. For RNA viruses, infection was determined by RT-qPCR; in the case of GBVA and begomoviruses, detection was performed using PCR. The presence of these viruses was further confirmed by high-throughput sequence (HTS) analysis of bulked samples (15x) which allowed the complete sequencing of PFYMV, SMV and GBVA. PFYMV and SMV were the most prevalent viruses in adult plants. PFYMV was detected in 33.3 % of symptomatic and 46.6 % of asymptomatic plants, while SMV was found in 33.3 % of symptomatic, and 20 % of asymptomatic plants. For GVBA and CMV, the prevalence was below 26.6 %. Interestingly, these four viruses had a high prevalence in sprouting seeds (SMV: 40 %, CMV: 13.3 %, PFYMV: 86.6 % and GBVA: 53.3 %) suggesting that sexual seeds are important for virus transmission in gulupa. Plantlets commercialized in the region showed significant levels of SMV (86.6 %), PFYMV (60 %), and GBVA (53.3 %). CABMV and begomoviruses were not detected in any sample. These results highlight the need of implementing virus seed certification schemes for this crop, La gulupa (Passiflora edulis f. edulis) es uno de los frutales con mayor crecimiento en los últimos años y de gran influencia en la economía de Antioquia (Colombia); sin embargo, su cultivo es afectado por diferentes problemas fitosanitarios, especialmente la marchitez por Fusarium oxysporum y enfermedades virales. En este estudio se evaluó la prevalencia de cuatro virus de ARN (SMV, CABMV, PFYMV y CMV) mediante RT-qPCR, virus del género Begomovirus y del badnavirus GBVA por PCR, a partir de muestras sintomáticas (SI) y asintomáticas (AS) obtenidas en 15 lotes, 15 grupos de plántulas (PL) y 15 muestras de semilla sexual en el oriente de Antioquia. Los genomas de los virus fueron ensamblados utilizando secuenciación masiva (HTS) a partir de grupos de muestras (15x). Con excepción de CABMV y begomovirus, los otros virus fueron encontrados en las muestras sintomáticas y asintomáticas, siendo el PFYMV (SI=33,3 % y AS=46,6 %) y SMV (SI=33,3 % y AS=20 %) los de mayor prevalencia, mientras que GBVA y CMV se detectaron en niveles inferiores al 26,6 %. De forma interesante, los cuatro virus detectados se encontraron en evaluaciones sobre brotes de semillas recién germinadas (SMV=40 %, CMV=13,3 %, PFYMV=86,6 %, GBVA=53,3 %), lo que sugiere que la semilla sexual juega un papel importante en la transmisión de estos virus en gulupa, así como también las plántulas comercializadas en esta región (SMV=86,6 %, CMV=0 %, PFYMV=60 %, GBVA=53,3 %). Mediante HTS fue posible el ensamblaje completo de los genomas de PFYMV, SMV y GBVA. Estos resultados enfatizan la necesidad de generar material certificado por su sanidad viral en gulupa
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- 2022
19. Detección molecular de virus en cultivos, plántulas y semillas de gulupa (Passiflora edulis f. edulis) en el oriente de Antioquia
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Cardona, Daniela, primary, Gallo García, Yuliana, additional, Higuita, Mónica, additional, Hoyos Sánchez, Rodrigo, additional, Gutiérrez Sánchez, Pablo, additional, and Marín Montoya, Mauricio, additional
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- 2022
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20. Natural infection of purple passion fruit (Passiflora edulis f. edulis) by a novel member of the family Tymoviridae in Colombia
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Cardona, Daniela, primary, Restrepo, Andrea, additional, Higuita, Mónica, additional, Gallo, Yuliana, additional, Marin, Mauricio, additional, and Gutiérrez, Pablo, additional
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- 2022
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21. VEXAS syndrome in a female patient with constitutional 45,X (Turner syndrome)
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Stubbins, Ryan J., primary, McGinnis, Eric, additional, Johal, Bhupinder, additional, Chen, Luke YC, additional, Wilson, Lorena, additional, Cardona, Daniela Ospina, additional, and Nevill, Thomas J., additional
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- 2021
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22. Novel somatic mutations in UBA1 as a cause of VEXAS syndrome
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Poulter, James A., Collins, Jason C., Cargo, Catherine, De Tute, Ruth M., Evans, Paul, Ospina Cardona, Daniela, Bowen, David T., Cunnington, Joanna R., Baguley, Elaine, Quinn, Mark, Green, Michael, McGonagle, Dennis, Beck, David B., Werner, Achim, and Savic, Sinisa
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- 2021
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23. Virome analysis for identification of viruses associated with asymptomatic infection of purple passion fruit (Passiflora edulis f. edulis) in Colombia
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Sepúlveda, Mariana, primary, Cardona, Daniela, additional, García, Yuliana Gallo, additional, Higuita, Mónica, additional, Gutiérrez, Pablo A., additional, and Marín, Mauricio, additional
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- 2021
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24. Technological didactic tools as support in sexual and reproductive health in adolescents
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Henríquez Cardona, Daniela, Márceles Pacheco, Lizeth Karolay, Márquez Salcedo, Leisy Grey, Matta Padilla, María José, Ramírez Rodríguez, Sharid Michell, Rodríguez Zambrano, Melanie Georgeth, Sánchez Hernández, Leslie Julieth, and Aldana R., Edna Elizabeth
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Salud sexual ,Knowledge ,Conocimiento ,Adolescent ,Sexual health ,Reproductive health ,Salud reproductiva ,Tool use behavior ,Comportamiento del uso de la herramienta ,Adolescente - Abstract
Introducción: Actualmente con el fenómeno de globalización se asumen retos frente a los cambios de índole educativo, socioeconómico, político en donde los cambios sociales se producen en la medida en que las sociedades adquieren nuevos conocimientos y en especial, evolucionan con el avance de su tecnología, con base en lo anterior se pretende diseñar una herramienta tecnológica didáctica para el aprendizaje de las dimensiones de la SSR y está dirigido a estudiantes adolescentes y jóvenes de la ciudad de Barranquilla. Material y Método: Se realizó un enfoque mixto sobre las herramientas tecnológicas de salud sexual y reproductiva donde expertos explican métodos cualitativos y cuantitativos del enfoque mixto. Los criterios de inclusión fueron investigaciones en estudiantes de los tres primeros semestres de la salud, donde fueron adolescentes de 16 a 19 años con 12 participantes. Resultados: La Salud sexual y reproductiva en adolescentes, se abordó desde un enfoque mixto. Donde los datos de composición de la población de estudio muestran una caracterización de sexo, donde un 45,5% son mujeres y el 54.5% corresponde a jóvenes y adolescentes hombres; la edad según su clasificación de 10-14 años se relaciona con un 27% de personas, entre los 15-17 años 64% y en la adolescencia tardía 18-21 años un 9%. Introduction: Currently, with the phenomenon of globalization, challenges are assumed in the face of changes of an educational, socioeconomic, and political nature where social changes occur as societies acquire new knowledge and especially, evolve with the advancement of their technology Based on the above, it is intended to design a didactic technological tool for learning the dimensions of the SRH and is aimed at adolescent and young students in the city of Barranquilla. Material and Method: A mixed approach was carried out on the technological tools of sexual and reproductive health where experts explain qualitative and quantitative methods of the mixed approach. The inclusion criteria were investigations in students from the first three semesters of health, where they were adolescents aged 16 to 19 years with 12 participants. Results: Sexual and reproductive health in college adolescents was approached from a mixed approach. Where the composition data of the study population show a characterization of sex, where 45.5% are women and 54.5% correspond to young men and adolescents; age according to its classification of 10-14 years is related to 27% of people, between 15-17 years 64% and in late adolescence 18-21 years 9%.
- Published
- 2021
25. Virome analysis for identification of viruses associated with asymptomatic infection of purple passion fruit (Passiflora edulis f. edulis) in Colombia
- Author
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Sep��lveda, Mariana, Cardona, Daniela, Garc��a, Yuliana Gallo, Higuita, M��nica, Guti��rrez, Pablo A., and Mar��n, Mauricio
- Subjects
food and beverages - Abstract
Purple passion fruit, one of the most important fruit exports in Colombia, has been seriously affected in recent years by several viral diseases. The aim of the present study was to investigate the virome of asymptomatic purple passion fruit samples from commercial plots and nurseries in Antioquia (Colombia). The presence of viruses was first tested by high-throughput sequencing (HTS) of bulked leaf samples using total RNA and dsRNA inputs. Interestingly, the HTS data suggested the presence of a new badnavirus with a genome of 6,951 bp, which was confirmed by DNA sequencing of rolling circle amplification products. This virus has been tentatively named Badnavirus passiflorae as it is the first report of a badnavirus infecting passion fruit. The presence of Soybean mosaic virus (SMV), Cowpea aphid-borne mosaic virus (CABMV), Cucumber mosaic virus (CMV), and Passion fruit yellow mosaic virus (PFYMV) was further investigated using RT-qPCR, as well as evaluated the infection by begomoviruses and badnaviruses through PCR. Using these techniques, B. passiflorae was detected in all the samples, PFYMV in 20% of adult plants and 10% of plantlets, and SMV in 20% of adult plants and 30% of plantlets. None of the samples tested positive for CABMV, CMV, or begomoviruses.
- Published
- 2021
- Full Text
- View/download PDF
26. Instalaci��n de toracostom��a utilizando un modelo porcino ex vivo. Telementoring para pregrado en tiempos de COVID-19
- Author
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Cardona, Daniela, Zuluaga, Alejandra Chac��n, Rojas, Vanessa Montoya, Mu��oz, Maria Camila Mora, and Figueroa, Luis
- Published
- 2021
- Full Text
- View/download PDF
27. Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS
- Author
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Ferrada, Marcela A., primary, Sikora, Keith A., additional, Luo, Yiming, additional, Wells, Kristina V., additional, Patel, Bhavisha, additional, Groarke, Emma M., additional, Ospina Cardona, Daniela, additional, Rominger, Emily, additional, Hoffmann, Patrycja, additional, Le, Mimi T., additional, Deng, Zuoming, additional, Quinn, Kaitlin A., additional, Rose, Emily, additional, Tsai, Wanxia L., additional, Wigerblad, Gustaf, additional, Goodspeed, Wendy, additional, Jones, Anne, additional, Wilson, Lorena, additional, Schnappauf, Oskar, additional, Laird, Ryan S., additional, Kim, Jeff, additional, Allen, Clint, additional, Sirajuddin, Arlene, additional, Chen, Marcus, additional, Gadina, Massimo, additional, Calvo, Katherine R., additional, Kaplan, Mariana J., additional, Colbert, Robert A., additional, Aksentijevich, Ivona, additional, Young, Neal S., additional, Savic, Sinisa, additional, Kastner, Daniel L., additional, Ombrello, Amanda K., additional, Beck, David B., additional, and Grayson, Peter C., additional
- Published
- 2021
- Full Text
- View/download PDF
28. Modalidad de cobertura por reclamación o “Claims made” en Colombia
- Author
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Begué Hoyos, María del Pilar, primary and Valencia Cardona, Daniela, additional
- Published
- 2021
- Full Text
- View/download PDF
29. Next generation sequencing panel screening of 320 patients with clinically unclassified systemic autoinflammatory diseases
- Author
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Schnappauf, Oskar, primary, Wang, Hongying, additional, Deuitch, Natalie, additional, Moura, Natalia Sampaio, additional, Rosenzweig, Sofia, additional, Cardona, Daniela Ospina, additional, Hoffmann, Patrycja, additional, Stone, Deborah, additional, Ombrello, Amanda, additional, Kastner, Daniel, additional, and Aksentijevich, Ivona, additional
- Published
- 2021
- Full Text
- View/download PDF
30. Teorías de Enfermería: sistematización de una experiencia pedagógica
- Author
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Wilches Flórez, Olga Cecilia, primary, Hincapié Otálvaro, Natalia, additional, and Restrepo Cardona, Daniela, additional
- Published
- 2020
- Full Text
- View/download PDF
31. Evidence of transfer of miRNAs from the diet to the blood still inconclusive
- Author
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Mar-Aguilar, Fermín, primary, Arreola-Triana, Alejandra, additional, Mata-Cardona, Daniela, additional, Gonzalez-Villasana, Vianey, additional, Rodríguez-Padilla, Cristina, additional, and Reséndez-Pérez, Diana, additional
- Published
- 2020
- Full Text
- View/download PDF
32. Evaluación y tratamiento polimodal del dolor musculo esquelético y abdominal en equinos.
- Author
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Reyes Cardona, Daniela, primary and Jaramillo Hernández, Dumar Alexander, additional
- Published
- 2020
- Full Text
- View/download PDF
33. Virome analysis for identification of viruses associated with asymptomatic infection of purple passion fruit (Passiflora edulis f. edulis) in Colombia.
- Author
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Sepúlveda, Mariana, Cardona, Daniela, García, Yuliana Gallo, Higuita, Mónica, Gutiérrez, Pablo A., and Marín, Mauricio
- Subjects
PASSION fruit ,VIRUS identification ,CUCUMBER mosaic virus ,SOYBEAN mosaic virus ,VIRUS diseases - Abstract
Purple passion fruit, one of the most important fruit exports in Colombia, has been seriously affected in recent years by several viral diseases. The aim of the present study was to investigate the virome of asymptomatic purple passion fruit samples from commercial plots and nurseries in Antioquia (Colombia). The presence of viruses was first tested by high-throughput sequencing (HTS) of bulked leaf samples using total RNA and dsRNA inputs. Interestingly, the HTS data suggested the presence of a new badnavirus with a genome of 6,951 bp, which was confirmed by DNA sequencing of rolling circle amplification products. This virus has been tentatively named Badnavirus passiflorae as it is the first report of a badnavirus infecting passion fruit. The presence of Soybean mosaic virus (SMV), Cowpea aphid-borne mosaic virus (CABMV), Cucumber mosaic virus (CMV), and Passion fruit yellow mosaic virus (PFYMV) was further investigated using RT-qPCR, as well as evaluated the infection by begomoviruses and badnaviruses through PCR. Using these techniques, B. passiflorae was detected in all the samples, PFYMV in 20% of adult plants and 10% of plantlets, and SMV in 20% of adult plants and 30% of plantlets. None of the samples tested positive for CABMV, CMV, or begomoviruses. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
34. Organizational change management: case study applied to the corporate reorganization of a company in the mining sector
- Author
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García Castrillón, Carlos Felipe, Urrea Cardona, Daniela, and Giraldo, Juliana
- Subjects
Gestión del cambio organizacional ,Planeación estratégica ,Administración general ,Reorganización empresarial para la sostenibilidad ,Strategic planning ,Empresas multilatinas mineras ,Modelos para la gestión del cambio ,Multilatinas mining companies ,Models for change management ,Comunication, change management, leadership, reorganization and sustainability ,Business reorganization for sustainability ,Organizational change management - Abstract
El cambio se origina cada vez con mayor velocidad de acuerdo con los intereses de la empresa y el entorno, exigiendo mayor capacidad de adaptación con el fin de lograr el desarrollo sostenible y perdurable. Este es el caso de una multilatina minera en condiciones de reorganización societaria y proyectos de expansión que busca consolidar operaciones a nivel global. La gestión del cambio en la empresa de estudio se enfoca en seis pilares de trabajo; compras-operaciones, tecnología, financiera, jurídica, recursos humanos y gobierno corporativo, teniendo como factor común y fuente de movilización, el recurso humano. La metodología aplicada se conceptualiza a través de los modelos Awareness, Desire, Knowledge, Ability, Reinforcement ADKAR®, Human Change Managment Body of Knowledge HCMBOK® y el modelo Denison. El objetivo de este proyecto consiste en facilitar una herramienta de gestión del cambio organizacional centrada en el colaborador, para que a través de los rasgos de cultura se logre orientar la visión de los lideres entorno a la movilización, la consistencia en la gestión de los interesados, el patrocinio genuino de la dirección y una estrategia como base para la apropiación del cambio deseado. The business environment nowadays, where change occurs faster, demands greater adaptability in order to achieve sustainable and lasting development. This is the case of a LATAM mining company in conditions of corporate reorganization and expansion projects, that seeks to consolidate operations at a global level. Change management in the study company focuses on six work pillars; purchasing-operations, technology, financial, legal, human resources and corporate governance, having the human resources as a common factor and source of mobilization. The applied methodology is conceptualized through the Awareness, Desire, Knowledge, Ability, Reinforcement ADKAR®, Human Change Management Body of Knowledge HCMBOK® and the Denison model. The objective of this project is to facilitate an organizational change management tool focused on the employee, thus, through cultural features make possible a guiding vision of the leaders around mobilization, consistency in the management of stakeholders , genuine management sponsorship and a strategy as the basis for ownership of the desired change.
- Published
- 2020
- Full Text
- View/download PDF
35. Curvas Intensidad-Duración-Frecuencia no estacionarias para la cuenca del río Medellín
- Author
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Grajales-Cardona, Daniela and Carvajal-Serna, Luis Fernando
- Subjects
climate variability ,no-estacionario ,non-stationarity ,curvas IDF ,test de Mann Kendall ,IDF curves ,L-momentos ,precipitation ,Mann Kendall test ,precipitación ,Gumbel ,climate change ,L-moments ,variabilidad climática ,cambio climático - Abstract
The current Intensity-Duration-Frequency (IDF) curves assume that the precipitation does not vary significantly in time, what induces to underestimate the extreme events and at the same time increases the risk of flooding and damage to the infrastructure. As a consequence, methodologies that allow the estimation of climate change condition should be studied, taking into account a non- stationary approach as the one used in this study, in which stationary and non-stationary IDF curves were estimated for 9 pluviographic stations located in the Medellin river basin. To adjust the precipitation time series, the distribution of extreme values EV1 was used; its stationary parameters were calculated by means of the L-moments method and the non-stationary ones by the mobile windows. The effect of climate change on high intensities and small durations have been evidenced, obtaining that the stationary approach can underestimate extreme events up to 39%. Resumen Las curvas Intensidad-Duración-Frecuencia (IDF) actuales suponen que la precipitación no varía significativamente con el tiempo, subestimando así sus eventos extremos, lo que aumenta el riesgo de inundaciones y de daños en la infraestructura, es por esto que se deben estudiar metodologías que permitan su estimación en condición de cambio climático, es decir, con un enfoque no estacionario, tal como en este estudio, en el que se estimaron curvas IDF estacionarias y no estacionarias para 9 estaciones pluviográficas dispuestas sobre la cuenca del río Medellín. Para ajustar las series de tiempo de precipitación se hizo uso de la distribución de valores extremos EV1, sus parámetros estacionarios fueron calculados por medio del método de los L-momentos y los no estacionarios por el de ventanas móviles. Se evidencia el efecto del cambio climático en intensidades altas y duraciones pequeñas, obteniéndose que el enfoque estacionario puede subestimar los eventos extremos hasta en un 39%.
- Published
- 2019
36. Evidence of transfer of miRNAs from the diet to the blood still inconclusive
- Author
-
Mar Aguilar, Fermín, Arreola Triana, Alejandra, Mata Cardona, Daniela Alejandra, González Villasana, Vianey, Rodríguez Padilla, Cristina, Reséndez Pérez, Diana, Mar Aguilar, Fermín, Arreola Triana, Alejandra, Mata Cardona, Daniela Alejandra, González Villasana, Vianey, Rodríguez Padilla, Cristina, and Reséndez Pérez, Diana
- Published
- 2020
37. Cannabis y alteraciones de la memoria. Mitos y realidades
- Author
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Rodríguez Cardona, Daniela, Echavarría Calderón, Natalia, and Uribe Aramburo, Nicolás Ignacio
- Subjects
Neuropsicología cognitiva ,Psicología clínica ,Drogadicción ,Altered ,Memoria semántica ,Marihuana ,Psicología ,Memory ,Mito ,Memoria ,Psychology ,Adicción ,Neuropsicología ,Alteración ,Cannabis ,Myth - Abstract
Overview using the technique of document review, collected information on the existing scientific evidence about the memory disturbance associated with cannabis use, challenging myths that deny the harmful effects of the use of these substances, as well as myths that exaggerate the damage on individuals. It seeks to sensitize professionals and students of psychology and social science, as well as parents, teacher and people who use cannabis, about the real effects that can lead to mental health, so campaigns and prevention programs can have a greater impact that contributes to the improvement of the quality of life of the people. Utilizando la técnica de revisión documental, se recopila información sobre las evidencias científicas existentes acerca de las alteraciones de la memoria asociadas al consumo de cannabis, cuestionando mitos que niegan los efectos nocivos del uso de estas sustancias, así como mitos que exageran los perjuicios sobre los individuos. Se busca sensibilizar a los profesionales y estudiantes de la psicología y las ciencias sociales, así como a padres de familia, maestros y personas que usan el cannabis, acerca de los verdaderos efectos que pueden acarrear sobre la salud mental, de modo que las campañas y programas de prevención puedan tener un sustento más realista que permita obtener un mayor impacto que aporte al mejoramiento de la calidad de vida de las personas
- Published
- 2018
38. Virome analysis for identification of viruses associated with asymptomatic infection of purple passion fruit (Passiflora edulisf. edulis) in Colombia
- Author
-
Sepúlveda, Mariana, Cardona, Daniela, García, Yuliana Gallo, Higuita, Mónica, Gutiérrez, Pablo A., and Marín, Mauricio
- Abstract
ABSTRACTPurple passion fruit, one of the most important fruit exports in Colombia, has been seriously affected in recent years by several viral diseases. The aim of the present study was to investigate the virome of asymptomatic purple passion fruit samples from commercial plots and nurseries in Antioquia (Colombia). The presence of viruses was first tested by high-throughput sequencing (HTS) of bulked leaf samples using total RNA and dsRNA inputs. Interestingly, the HTS data suggested the presence of a new badnavirus with a genome of 6,951 bp, which was confirmed by DNA sequencing of rolling circle amplification products. This virus has been tentatively named Badnavirus passifloraeas it is the first report of a badnavirus infecting passion fruit. The presence of Soybean mosaic virus(SMV), Cowpea aphid-borne mosaic virus(CABMV), Cucumber mosaic virus(CMV), and Passion fruit yellow mosaic virus(PFYMV) was further investigated using RT-qPCR, as well as evaluated the infection by begomoviruses and badnaviruses through PCR. Using these techniques, B. passifloraewas detected in all the samples, PFYMV in 20% of adult plants and 10% of plantlets, and SMV in 20% of adult plants and 30% of plantlets. None of the samples tested positive for CABMV, CMV, or begomoviruses.
- Published
- 2022
- Full Text
- View/download PDF
39. Nonstationary Intesity-Duration-Frequency curves for Medellin river basin
- Author
-
Carvajal-Serna, Luis Fernando, Grajales-Cardona, Daniela, Carvajal-Serna, Luis Fernando, and Grajales-Cardona, Daniela
- Abstract
The current Intensity-Duration-Frequency (IDF) curves assume that the precipitation does not vary significantly in time, what induces to underestimate the extreme events and at the same time increases the risk of flooding and damage to the infrastructure. As a consequence, methodologies that allow the estimation of climate change condition should be studied, taking into account a non- stationary approach as the one used in this study, in which stationary and non-stationary IDF curves were estimated for 9 pluviographic stations located in the Medellin river basin. To adjust the precipitation time series, the distribution of extreme values EV1 was used; its stationary parameters were calculated by means of the L-moments method and the non-stationary ones by the mobile windows. The effect of climate change on high intensities and small durations have been evidenced, obtaining that the stationary approach can underestimate extreme events up to 39%., Las curvas Intensidad-Duración-Frecuencia (IDF) actuales suponen que la precipitación no varía significativamente con el tiempo, subestimando así sus eventos extremos, lo que aumenta el riesgo de inundaciones y de daños en la infraestructura, es por esto que se deben estudiar metodologías que permitan su estimación en condición de cambio climático, es decir, con un enfoque no estacionario, tal como en este estudio, en el que se estimaron curvas IDF estacionarias y no estacionarias para 9 estaciones pluviográficas dispuestas sobre la cuenca del río Medellín. Para ajustar las series de tiempo de precipitación se hizo uso de la distribución de valores extremos EV1, sus parámetros estacionarios fueron calculados por medio del método de los L-momentos y los no estacionarios por el de ventanas móviles. Se evidencia el efecto del cambio climático en intensidades altas y duraciones pequeñas, obteniéndose que el enfoque estacionario puede subestimar los eventos extremos hasta en un 39%.
- Published
- 2019
40. Curvas Intensidad-Duración-Frecuencia no estacionarias para la cuenca del río Medellín
- Author
-
Grajales Cardona, Daniela, Carvajal Serna, Luis Fernando, Grajales Cardona, Daniela, and Carvajal Serna, Luis Fernando
- Abstract
The current Intensity-Duration-Frequency (IDF) curves assume that the precipitation does not vary significantly in time, what induces to underestimate the extreme events and at the same time increases the risk of flooding and damage to the infrastructure. As a consequence, methodologies that allow the estimation of climate change condition should be studied, taking into account a non- stationary approach as the one used in this study, in which stationary and non-stationary IDF curves were estimated for 9 pluviographic stations located in the Medellin river basin. To adjust the precipitation time series, the distribution of extreme values EV1 was used; its stationary parameters were calculated by means of the L-moments method and the non-stationary ones by the mobile windows. The effect of climate change on high intensities and small durations have been evidenced, obtaining that the stationary approach can underestimate extreme events up to 39%, Las curvas Intensidad-Duración-Frecuencia (IDF) actuales suponen que la precipitación no varía significativamente con el tiempo, subestimando así sus eventos extremos, lo que aumenta el riesgo de inundaciones y de daños en la infraestructura, es por esto que se deben estudiar metodologías que permitan su estimación en condición de cambio climático, es decir, con un enfoque no estacionario, tal como en este estudio, en el que se estimaron curvas IDF estacionarias y no estacionarias para 9 estaciones pluviográficas dispuestas sobre la cuenca del río Medellín. Para ajustar las series de tiempo de precipitación se hizo uso de la distribución de valores extremos EV1, sus parámetros estacionarios fueron calculados por medio del método de los L-momentos y los no estacionarios por el de ventanas móviles. Se evidencia el efecto del cambio climático en intensidades altas y duraciones pequeñas, obteniéndose que el enfoque estacionario puede subestimar los eventos extremos hasta en un 39%
- Published
- 2019
41. Modelo de negocios para la creación de un restaurante especializado en comida saludable, en Cartago, Valle del Cauca, en el año 2019
- Author
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Duque Cardona, Daniela, Giraldo Hernández, Gina María, and Giraldo Ortíz, Lady Janeth
- Subjects
Modelo de negocio ,Metodología CANVAS ,Restaurants, lunch rooms, etc ,NUEVAS EMPRESAS - CARTAGO (VALLE DEL CAUCA - COLOMBIA) ,Alimentos saludables ,Customer relations ,New business enterprises - Cartago (Valle del Cauca - Colombia) ,Emprendimiento ,RESTAURANTES, CAFETERÍAS. ETC ,Alimentos saludables personalizados ,RELACIONES CON LOS CLIENTES - Abstract
El presente modelo de negocios para la creación de un restaurante especializado en comida saludable, en Cartago, Valle del Cauca, en el año 2019, se desarrolló utilizando la metodología Canvas, por medio de una investigación de tipo exploratoria-descriptiva, que permitió conocer las necesidades y problemas de las personas a la hora de almorzar, el segmento objetivo y la aceptación de los posibles clientes frente a la propuesta de valor -- Así mismo permitió validar el tipo de relación que se debe tener con los clientes, los canales a usar, los recursos y actividades clave, las alianzas clave, la estructura de costos y la fuente de ingresos de la empresa que se quiere crear -- Con lo anterior se logró estructurar un modelo de negocio rentable, sostenible y escalable y de esta manera, minimizar los riesgos al emprender, This business model is about a restaurant specialized in healthy food, in Cartago, Valle del Cauca, Colombia in 2019. It was developed using the Canvas methodology, through an exploratory-descriptive research, which allowed to know the needs and problems people have at lunch time, the target segment and the acceptance that potential customers have regarding the value proposition. It also allowed to validate the type of relationship with the clients, the channels to be used, the resources and key activities, the key alliances, the cost structure and the source of income for the company to be created. With all this, it was possible to structure a profitable, sustainable and scalable business model and, in this way, minimize risks for the entrepreneur.
- Published
- 2018
42. eP427 - Next generation sequencing panel screening of 320 patients with clinically unclassified systemic autoinflammatory diseases
- Author
-
Schnappauf, Oskar, Wang, Hongying, Deuitch, Natalie, Moura, Natalia Sampaio, Rosenzweig, Sofia, Cardona, Daniela Ospina, Hoffmann, Patrycja, Stone, Deborah, Ombrello, Amanda, Kastner, Daniel, and Aksentijevich, Ivona
- Published
- 2021
- Full Text
- View/download PDF
43. Curvas Intensidad-Duración-Frecuencia no estacionarias para la cuenca del río Medellín
- Author
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Carvajal-Serna, Luis Fernando, primary and Grajales-Cardona, Daniela, additional
- Published
- 2019
- Full Text
- View/download PDF
44. MODALIDAD DE COBERTURA POR RECLAMACIÓN O "CLAIMS MADE" EN COLOMBIA.
- Author
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HOYOS, MARÍA DEL PILAR BEGUÉ and CARDONA, DANIELA VALENCIA
- Subjects
REINSURANCE ,INSURANCE ,ACTIONS & defenses (Law) ,JURISPRUDENCE ,MAGISTRATES & magistrates' courts ,INSURANCE policies - Abstract
Copyright of Revista Ibero-Latinoamericana de Seguros is the property of Pontificia Universidad Javeriana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
45. Hydrotreating Model Comparison of Raw Castor Oil and its Methyl Esters for Biofuel Production
- Author
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Mederos-Nieto, Fabián S., primary, Elizalde-Martínez, Ignacio, additional, Hernández-Altamirano, Raúl, additional, Trejo-Zárraga, Fernando, additional, Mena-Cervantes, Violeta Y., additional, Ramírez-Jiménez, Edgar, additional, and Vallarta-Cardona, Daniela E., additional
- Published
- 2018
- Full Text
- View/download PDF
46. Vivienda fiscal para la F.A.C. en territorio semiaridos aislados de la alta Guajira
- Author
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Bolaños Silva, Tomás / Asesor, Vargas Cardona, Daniela, Agudelo Nivia, Juan Sebastian, Bolaños Silva, Tomás / Asesor, Vargas Cardona, Daniela, and Agudelo Nivia, Juan Sebastian
- Abstract
This project begins with the identification and improvement of the main shortcomings that military architecture currently has in units built in the Colombian Guajira, this being the warmest territory in the country. From an analysis in macro, meso and micro scales, it was identified that the military units of this region have had a growth of functionalist character but not a planned design of the integration of the zones that requires a base, therefore, it has given greater priority to the functional and operational design of military dynamics, leaving aside the concept of "habitat" within this type of units, taking into account that a military base is also the place of residence of families; In addition, an architecture that responds to the climate, the territory or the important and current environmental awareness has not been implemented, thus generating conventional buildings that require air conditioning systems, among others. For this reason, the general design of the new Flor de la Guajira air base is proposed focused on the residential area, responding to an architecture that seeks to adapt to the climate and the territory, improving the housing quality of the members of the FAC and their families through 3 general guidelines. - The revitalization of the ecological structure, strengthening the native reforestation, This project begins with the identification and improvement of the main shortcomings that military architecture currently has in units built in the Colombian Guajira, this being the warmest territory in the country. From an analysis in macro, meso and micro scales, it was identified that the military units of this region have had a growth of functionalist character but not a planned design of the integration of the zones that requires a base, therefore, it has given greater priority to the functional and operational design of military dynamics, leaving aside the concept of "habitat" within this type of units, taking into account that a military base is also the place of residence of families; In addition, an architecture that responds to the climate, the territory or the important and current environmental awareness has not been implemented, thus generating conventional buildings that require air conditioning systems, among others. For this reason, the general design of the new Flor de la Guajira air base is proposed, focused on the residential area, responding to an architecture that seeks to adapt to the climate and the territory, improving the housing quality of the members of the FAC and their families through 3 general guidelines. - The revitalization of the ecological structure, strengthening the native reforestation. - The implementation of strategies based on natural forms of cooling. - The improvement of habitat and image in the design of spaces proposed for families within a military unit. To respond to these approaches, a research based on the techniques used by architecture in similar climatic conditions, such as Iranian architecture, which uses efficient ways to achieve a comfortable climate using wind towers (badgir) that allow the temperature decrease significantly within a building, without using energy, generating a positive change in the atmospheric sensation with the use of a natural resource, in this case, the wind. Finally, the main contribution
- Published
- 2018
47. Modelo de negocios para la creación de un restaurante especializado en comida saludable, en Cartago, Valle del Cauca, en el año 2019
- Author
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Giraldo Hernández, Gina María, Giraldo Ortíz, Lady Janeth, Duque Cardona, Daniela, Giraldo Hernández, Gina María, Giraldo Ortíz, Lady Janeth, and Duque Cardona, Daniela
- Abstract
El presente modelo de negocios para la creación de un restaurante especializado en comida saludable, en Cartago, Valle del Cauca, en el año 2019, se desarrolló utilizando la metodología Canvas, por medio de una investigación de tipo exploratoria-descriptiva, que permitió conocer las necesidades y problemas de las personas a la hora de almorzar, el segmento objetivo y la aceptación de los posibles clientes frente a la propuesta de valor -- Así mismo permitió validar el tipo de relación que se debe tener con los clientes, los canales a usar, los recursos y actividades clave, las alianzas clave, la estructura de costos y la fuente de ingresos de la empresa que se quiere crear -- Con lo anterior se logró estructurar un modelo de negocio rentable, sostenible y escalable y de esta manera, minimizar los riesgos al emprender, This business model is about a restaurant specialized in healthy food, in Cartago, Valle del Cauca, Colombia in 2019. It was developed using the Canvas methodology, through an exploratory-descriptive research, which allowed to know the needs and problems people have at lunch time, the target segment and the acceptance that potential customers have regarding the value proposition. It also allowed to validate the type of relationship with the clients, the channels to be used, the resources and key activities, the key alliances, the cost structure and the source of income for the company to be created. With all this, it was possible to structure a profitable, sustainable and scalable business model and, in this way, minimize risks for the entrepreneur.
- Published
- 2018
48. Detección de microRNAs en plasma humano posterior a la ingesta de una dieta con carne de res.
- Author
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Mata Cardona, Daniela Alejandra and Mata Cardona, Daniela Alejandra
- Abstract
En años recientes, se ha postulado que la transferencia horizontal de microRNAs entre especies e incluso entre reinos es posible, aunque se ha mostrado que miRNAs ingeridos pueden atravesar la barrera intestinal también existen estudios en dónde no ha sido posible demostrar dicha transferencia. Debido a que los tejidos de bovino contienen perfiles únicos de miRNAs homólogos a humanos y que éstos sobreviven a métodos de preparación basados en calor, en la presente tesis se determinó si el aumento de la expresión de los miRNAs en plasma humano es debido a la transferencia de miRNAs proveniente de un tiempo de alimentación con carne de res. La estrategia experimental consistió en la obtención del plasma en ayuno de un grupo con dieta omnívora y un grupo control vegano a los que se les brindó una dieta con carne y sin carne de res respectivamente y se obtuvo el plasma a las 2, 4 y 6 horas postprandiales. Posteriormente, se realizó la extracción de los RNAs totales, el perfil de expresión de miRNAs por Secuenciación de Nueva Generación (NGS) y finalmente se obtuvo la cuantificación relativa de los miRNAs seleccionados mediante qPCR. Los resultados del panel piloto de miRNAs por NGS mostraron que al comparar el tiempo postprandial del grupo omnívoro con el grupo vegano se observó incrementado 1.24 veces la expresión miR-1 mientras que miR-22 se mostró disminuido 1.29 veces y presentó variabilidad en las dos muestras analizadas. La cuantificación mediante qPCR en el total de las muestras no mostró diferencia significativa en los niveles de expresión basales y postprandiales de los miRNAs 1, 10b, 22 y 92 en el grupo omnívoro comparado con el grupo vegano. Interesantemente, se encontró una disminución significativa no descrita a la fecha de la expresión basal de miR-192 en el grupo omnívoro comparado con el grupo vegano, un miRNA con relevancia en cáncer de colon. En conclusión, un tiempo de comida con carne no promueve la transferencia de los miRNAs analizados a pesar que é
- Published
- 2016
49. Diseño e implementación de un sistema de indicadores de gestión en la Lavandería Classic Dry Cleaning® Bogotá bajo la metodología del Balanced Scorecard
- Author
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Urrea Cardona, Daniela and Restrepo Digiammarco, Daniela
- Subjects
Business Enterprises - Management ,Production management ,Modelado de procesos de negocio (BPMN) ,Cuadro de mando integral ,ADMINISTRACIÓN DE EMPRESAS ,CULTURA CORPORATIVA ,Indicadores de gestión ,ADMINISTRACIÓN DE LA PRODUCCIÓN ,Laundries ,Strategic Planning ,Corporate culture ,GESTIÓN INDUSTRIAL ,MEJORAMIENTO DE PROCESOS ,Industrial procurement ,PLANIFICACIÓN ESTRATÉGICA ,LAVANDERÍAS ,Process improvement - Published
- 2014
50. Nonstationary Intesity-Duration-Frequency curves for Medellin river basin.
- Author
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Grajales-Cardona, Daniela and Carvajal-Serna, Luis Fernando
- Subjects
- *
WATERSHEDS , *EXTREME value theory , *FREQUENCY curves , *TIME series analysis , *FLOOD damage , *CLIMATE change - Abstract
The current Intensity-Duration-Frequency (IDF) curves assume that the precipitation does not vary significantly in time, what induces to underestimate the extreme events and at the same time increases the risk of flooding and damage to the infrastructure. As a consequence, methodologies that allow the estimation of climate change condition should be studied, taking into account a non-stationary approach as the one used in this study, in which stationary and non-stationary IDF curves were estimated for 9 pluviographic stations located in the Medellin river basin. To adjust the precipitation time series, the distribution of extreme values EV1 was used; its stationary parameters were calculated by means of the L-moments method and the non-stationary ones by the mobile windows. The effect of climate change on high intensities and small durations have been evidenced, obtaining that the stationary approach can underestimate extreme events up to 39%. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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