Search

This comprehensive book covers all aspects of cardiovascular health and disease. It begins with sections on cardiac diagnostic approaches like electrophysiology, ECG interpretation, cell death mechanisms, and myocardial perfusion imaging. A large section examines various cardiovascular diseases and related conditions, including gastroesophageal reflux disease, testosterone deficiency, multimorbidity, valvular disease, and rheumatic fever. Treatment strategies are covered next, with chapters on blood management techniques, infections of cardiac devices, anaesthesia for cardiomyopathies, and radiation safety in nuclear cardiology. The book then delves into advancements in the field such as artificial intelligence applications, cardiac resynchronization therapy, stress adaptation mechanisms, and more. Additional sections explore peripheral artery disease, patient cares like nursing for cardiac procedures, molecular pathways in myocardial hypertrophy, cardiac radiology, and mechanical cardiomyopathies. With its comprehensive scope and up-to-date information, this book serves as an invaluable tool for cardiologists, cardiothoracic surgeons, nurses, and any medical professional involved in caring for patients with cardiovascular disease. It also provides a solid foundation for students and residents training in the field.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and around the world. Major risk factors for CVD result from poor lifestyle habits and practices, but the area of lifestyle medicine has emerged to help clinicians and their patients understand the power of positive lifestyle habits and actions. Written by cardiologist and lifestyle medicine pioneer, Dr. James Rippe, Integrating Lifestyle Medicine in Cardiovascular Health and Disease Prevention introduces the principles of lifestyle medicine with the practice of cardiology to help lower the risk of heart disease and, if already present, assist in its treatment. This book provides evidence-based information on both the prevention and treatment of CVD through lifestyle measures such as regular physical activity, sound nutrition, weight management and avoidance of tobacco products. This information aids physicians and patients to better understand multiple linkages between poor habits and practices, employing them with associated behavioral techniques to lessen the likelihood of developing CVD. Features: Summarizes major issues in CVD including heart attack, stroke, atrial fibrillation, high blood pressure, lipid abnormalities and obesity. Provides protocols for overcoming a sedentary lifestyle and using lifestyle medicine techniques to optimize brain health. Empowers clinicians with vital information for consultations on the power of lifestyle medicine practices, both to treat symptoms if already present or to prevent major components of CVD from developing in the future. Written for practitioners at all levels, this user-friendly volume in the Lifestyle Medicine series is valuable to practitioners in general medicine or subspecialty practices including lifestyle medicine and cardiology.

Das Buch fasst in kompakter Form die neusten Entwicklungen auf dem komplexen Feld der ANCA-assoziierten Vaskulitis zusammen und erlaubt so einen schnellen und praxisrelevanten Überblick. Insbesondere sind die großen therapeutischen Fortschritte, wie z.B. mit Avacopan, Rituximab und Mepolizumab, beschrieben und alltagstauglich eingeordnet.

This book presents a systematic overview of the technologies currently being explored and utilized in the fields of cardiovascular tissue engineering and regenerative medicine. Considering the unprecedented rapid progress occurring on multiple technological fronts in cardiac tissue engineering, this important new volume fills a need for an up-to-date, comprehensive text on emerging advanced biological and engineering tools. The book is an important resource for anyone looking to understand the emerging topics that have the potential to substantially influence the future of the field. Coverage includes iPS stem cell technologies, nanotechnologies and nanomedicine, advanced biomanufacturing, 3D culture systems, 3D organoid systems, genetic approaches to cardiovascular tissue engineering, and organ on a chip. This book will be a valuable guide for research scientists, students, and clinical researchers in the fields of cardiovascular biology, medicine, and bioengineering, as well asindustry-based practitioners working in biomaterial science, nanomaterials and technology, and rapid prototyping and biomanufacturing (3D bioprinting).

Personalized Health Systems for Cardiovascular Disease is intended for researchers, developers, and designers in the field of p-health, with a specific focus on management of cardiovascular diseases. Biomedical engineers will benefit from coverage of sensors, data transmission, signal processing, data analysis, home and mobile applications, standards, and all other subject matters developed in this book in order to provide an integrated view of the different and multidisciplinary problems related to p-health systems. However, many chapters will also be interesting to physicians and other professionals who operate in the health domain. Students, MS and PhD level, mainly in technical universities, but also in medical schools, will find in this book a complete view of the manifold aspects of p-health, including technical problems related to sensors and software, to automatic evaluation and correct interpretation of the data, and also some legal and regulatory aspects. This book mainly focuses on the development of technology used by people and patients in the management of their own health. New wearable and implantable devices allow a continuous monitoring of chronic patients, with a direct involvement of clinical centers and physicians. Also, healthy people are more and more interested in keeping their own wellness under control, by adopting healthy lifestyles and identifying any early sign of risk. This is leading to personalized solutions via systems which are tailored to a specific patient/person and her/ his needs. However, many problems are still open when it comes to p-health systems. Which sensors and parameters should be used? Which software and analysis? When and how? How do you design an effective management plan for chronic pathologies such as cardiovascular diseases? What is useful feedback for the patient or for the clinician? And finally, what are the limits of this approach? What is the view of physicians? The purpose of this book is to provide, from a technical point of view, a complete description of most of the elements which are part of such systems, including the sensors and the hardware, the signal processing and data management procedures, the classification and stratification models, the standards and the regulations, focusing on the state of the art and identifying the new directions for innovative solutions. In this book, readers will find the fundamental elements that must be taken into account when developing devices and systems in the field of p-health. - Provides an integrated approach to design and development of p-health systems which involves sensors, analysis software, user interfaces, data modeling, and interpretation. - Covers standards and regulations on data privacy and security, plus safe design of devices. - Supported by case studies discussing development of actual solutions in the biomedical engineering field.

This book provides a guide to the assessment of patient reported outcomes measures and quality of life in cardiovascular interventions, which have become a fundamental component of decision making in bedside medicine, health policy, health economics, and public health. Cardiac surgery, cardiovascular interventions, vascular interventions, and the core principles of quality of life are all covered. This book is the first book to demonstrate how clinicians and policy makers can easily get access to a single source of quality of life and patient reported outcomes measures evidence to help them make the best informed decisions in the field of cardiovascular interventions. This is a rapidly emerging field and the book would be relevant to doctors, healthcare scientists, allied-health professionals, healthcare managers, medical statisticians, healthcare economists, and consultants working in healthcare.

This book covers the role of statins in all cardiovascular ailments, from prevention to disease management, and brought you the evolving pharmacological interventions. It is an attempt to interference with the cholesterol synthesis pathways through statins and bempedoic acid, and blocking PCSK9 from binding to LDL receptor by intercepting with antibodies or nipping them early by intracellular inhibition of the translation of message to proteins, the monograph brings into focus the ultimate importance of LDL receptors.

We are delighted to offer this textbook to the scientific community, entitled Endothelial Progenitor Cells in Health and Diseases, which covers a timely topic in the rapidly evolving discipline of vascular biology. Written primarily for a life science audience and clinicians, the fundamentals of EPCs biology and the latest characterization and definition in health and diseases are introduced, followed by explanations of the most cutting-edge cell therapy methods to cure ischemic diseases. In Section One, endothelial cell progenitor isolation methods and biological characterization were reported. The discovery of this novel endothelial progenitor cells (EPC) concept has overturned the previous dogma which suggested that vasculogenesis could only occur during embryogenesis. In fact, both vasculogenesis and angiogenesis may potentially have a synergistic role in postnatal revascularization. Also, this chapter summarized recent advances in EPC biology such as biological function, origin, definition, and classification. Each EPC culture and isolation method is clearly defined to prevent confusion in EPC biology. Section Two focuses on EPC biological function alteration in cardiovascular diseases (CVD). Several large clinical trials have reported that the number and biological function are strongly associated with major adverse cardiovascular events. The diagnostic and prognostic potential of EPC is crucial in terms of CVD. In Section Three, biological dysfunction mechanisms of EPC and their scarcity in diabetic patients'peripheral blood were clearly described. Preclinical studies have shown that EPC-based therapy is feasible, safe, and efficacious in multiple disease states. Subsequently, this has led to several clinical trials demonstrating the feasibility and safety profile of EPC therapy against cardiovascular ischemic diseases. In Section Four, regenerative medicine pioneers discussed EPCs translation to the clinic and cell transplantation challenges along with their solutions. Personalized stem cell-based therapy approaches employing several clinical biomarkers, disease-related genetic-trait evaluation methods, and advanced analyses with state-of-the-art computational methods such as machine learning-based prediction can increase cell therapies'efficacy and decrease treatment costs. The last chapter in the book describes a therapeutic application of EPC-derived extracellular vesicles to cure CVD.

Despite decades of aggressive pharmaceutical and surgical interventions, coronary artery disease (CAD) remains the number one killer of both men and women in the Western world. The most important aspect in the treatment of CAD is to focus on prevention. Indeed, prevention is easier than cure and when CAD does present itself, a combination of conventional and alternative methodologies can truly make a difference in people's lives. Building upon its predecessor, Nutritional and Integrative Strategies in Cardiovascular Medicine, Second Edition, provides scientific and clinical insight from leaders in the field of cardiovascular medicine who explore an integrative approach to treating and curing cardiovascular diseases through conventional and non-allopathic methodologies. Nutritional interventions with both appropriate non-inflammatory diets and targeted nutraceutical supports are simple and basic strategies to prevent as well as help manage CAD and congestive heart failure (CHF). In fact, nutritional strategies in the treatment of CHF have not only afforded patients a better quality of life but increased survival as well. This evidence-based book describes how to integrate nutrition, supplements, lifestyle changes, and medications for improved outcomes in hypertension, dyslipidemia, diabetes, coronary heart disease, congestive heart failure, infectious myocarditis and much more. Topics include: Covid-19: An evidence-based integrative approach to supporting the myocardium Metabolic cardiology: An exciting new way to manage heart failure Contains information on hypertension and dyslipidemia Naturopathic approaches Mediterranean diet as the longevity diet of the world Value of omega-3s and other fats Role of botanicals in the treatment of cardiovascular disease Integrative care of the patient in extending quality of life Gender-specific medicine – Perhaps a new evolving cardiovascular sub-specialty Role of dental disease inflammation and cardiovascular disease Environmental toxins and the heart Earthing and grounding as an energetic nutrition in healing the heart Autophagy and mTOR – the'new medicine'of the future Nutritional medicine is vitally important in the integrative care of the patient. This book will assist established health professionals as well as students preparing for advanced degrees in healthcare and offer cutting-edge and new information in cardiovascular medicine. It offers simple nutritional supports that can make the difference between not only easing human suffering, but also life and death.

En 1977, Andreas Gruentzig (Zurich) effectua la première dilatation d'un rétrécissement coronaire chez l'homme. Ce fut le départ de la cardiologie interventionnelle dont l'intérêt essentiel est de remplacer un traitement agressif (chirurgie de pontage aorto-coronaire), par une méthode légèrement invasive. L'auteur de ce livre, qui fut l'un des pionniers de cette nouvelle approche thérapeutique, y relate les débuts, les balbutiements, les améliorations successives, qui avec l'avènement du stent coronaire ont fait de l'angioplastie coronaire un traitement simple, sûr, efficace. Cette approche s'est étendue à d'autres domaines de la cardiologie, les cardiopathies congénitales et surtout la pathologie valvulaire aortique qui touche un grand nombre de sujets âgés, voire très âgés, qui cumulent d'autres comorbidités, rendant très risqué le remplacement valvulaire chirurgical. Aujourd'hui dans le monde, des millions de patients survivent et ont une amélioration de leur qualité de vie grâce à la cardiologie interventionnelle.

This book discusses all aspects of non-pharmacologic approaches to primary and secondary CVD prevention. It highlights the strength of evidence for particular diet styles in CVD prevention, including plant-based diets, the Mediterranean diet, the DASH diet, and low-carbohydrate diets. Chapters present evidence and future directions for diet and nutrition in diseases related to CVD, such as dyslipidemia, cardiometabolic disease (pre-diabetes, the metabolic syndrome, type-2 diabetes mellitus), and obesity. Finally, the book reviews novel and emerging aspects of dietary intervention in CVD prevention, such as dietary approaches to inflammation and the role of the microbiome in CVD. Up-to-date, evidence-based, and clinically oriented, Prevention and Treatment of Cardiovascular Disease: Nutritional and Dietary Approaches is an essential resource for physicians, residents, fellows, and medical students in cardiology, clinical nutrition, family medicine, endocrinology, and lipidology.

Nanomedicinal Approaches Towards Cardiovascular Disease summarizes information about nanotechnology that is used in the diagnosis and regenerative treatment of heart diseases. Chapters in this reference introduce the reader to the basics of cardiac nanomedicine and cardiac regeneration before moving to advanced topics such as nanomedicine in cardiovascular diagnosis, imaging and therapeutics.

This unique volume provides the latest information on secondary metabolites obtained from selected organisms (plants or microorganisms) that have beneficial effects in the treatment of cardiovascular diseases and an ability to offer protection against their progress. A detailed description of their source, chemistry and mechanism of action is provided, together with results of clinical studies. Here, a clear connection is made between chemical structures, in vitro studies and their clinical significance.The topic is extensive and the audience gains an understanding of the medicinal applications of these groups of secondary metabolites that have the potential to improve cardiovascular health.Features:The latest information on secondary metabolites with beneficial effects in the treatment of cardiovascular diseases.Written by an outstanding team of authors, their work provides new insights into the beneficial effects of different components present in well known plant products, evidencing their impressive cardiovascular effects.This volume discusses novel targets to screen for new drugs and the need for data obtained from clinical studies using natural products in order to better analyze the significance of in vitro experimental data.Here the reader will find a unique and timely volume with an international flavor.This book describes the source, chemistry and mechanism of action of natural products with the potential to improve cardiovascular health.

This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine.Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Handbook of Vascular Motion provides a comprehensive review of the strategies and methods to quantify vascular motion and deformations relevant for cardiovascular device design and mechanical durability evaluation. It also explains the current state of knowledge of vascular beds that are particularly important for the medical device industry. Finally, it explores the application of vascular motion to computational simulations, benchtop testing and fatigue analysis, as well as further implications on clinical outcomes, product development and business. - PROSE Book Award Nominee in the'Single Volume Reference Book'category - Describes methods to quantify vascular motion and deformations including choosing what data to collect, relevant medical imaging, image processing, geometric modeling, and deformation quantification techniques - Includes deformations for vascular beds of particular importance in medical devices including the coronary arteries and heart, arteries of the head and neck, thoracic aorta and arch branches, abdominal aorta and visceral branches, lower extremity arteries, inferior vena cava, and lower extremity veins - Explains how to convert raw deformations into boundary conditions suitable for durability evaluation, provides examples of using this information for computational simulations, benchtop testing, and fatigue analysis, and illustrates examples of how vascular motion affect clinical outcomes, product development, and business

This book provides a comprehensive framework for developing heart teams to manage a variety of cardiovascular diseases. Management of cardiovascular diseases has changed dramatically in recent years due to developments in evidence-based practices and treatments as well as the introduction of new devices. The sequential method of referring patients from doctor to doctor is becoming an antiquated model. The future of cardiac care lies in developing multidisciplinary'Heart Teams'to provide patient-focused treatment for complex cardiovascular problems. This volume examines the history and evolution of cardiovascular care and technology and explains why the implementation of heart teams is absolutely necessary to the future of cardiac care. It analyzes the role of heart teams for heart failure, complex coronary revascularization, mitral valve disease, cardiac imaging, aortic valve disease, cardiac arrhythmias, and women's heart health. Finally, the book explores how heartteams work with hospital administration and the broader healthcare industry. Heart Teams for Treatment of Cardiovascular Disease: A Guide for Advancing Patient-Centered Cardiac Care is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, cardiac surgery, critical care medicine, and radiology.

Kardiovaskuläre Erkrankungen befinden sich in den Morbiditäts- und Mortalitätsstatistiken in Deutschland sowie im westeuropäischen Ausland auf den vordersten Plätzen. Eine vorrangige Rolle spielen der akute Myokardinfarkt neben der Myokardinsuffizienz und der Häufigkeitserhöhung von psychischen Störungen. Dabei werden nicht-beeinflussbare Risikofaktoren (Alter, Geschlecht, Genetik) ebenso als erkrankungs- und sterbewahrscheinlichkeitsförderlich angesehen wie beeinflussbare (Hypertonie, Hyperlipidämie, abdominale Adipositas, Diabetes Mellitus, psycho-soziale und psycho-physische Faktoren). Frauen im mittleren Erwachsenenalter haben den höchsten Anstieg der Herz-Kreislauf-Mortalität. Kardioprotektive Schutzfaktoren, wie ein kardiorespiratorisches Krafttraining, sollten diesen Risikofaktoren entgegenwirken. Dies ist aber nur möglich, wenn das Belastungs- und Beanspruchungsgefüge des Trainings so passend ist, dass es auch zu den gewünschten Effekten führt. Diese Publikation untersuchte die Effekte eines kardiorespiratorischen Krafttrainings bei Frauen im mittleren Erwachsenenalter. Es wurden verschiedene wissenschaftliche Methoden, u. a. Messung von Ausprägungen der Herzfrequenzvariabilität, eingesetzt, um Effekte auf das autonome Nervensystem sichtbar zu machen. Neben den wissenschaftlichen Ergebnissen dieser Untersuchung beinhaltet dieses Werk auch eine Vielzahl konkret umsetzbarer und wissenschaftlich begründeter Rahmentrainingspläne, um eine kardioprotektive Wirkung zu erzielen.

New Approaches to Aortic Disease from Valve to Abdominal Bifurcation provides a complete look at aortic valve diseases from all points of view, including etiology, physiopathology, prevention, diagnosis and treatment. The book offers new insights into the aortic valve and pathology based on evidence of current diagnostic methods, treatments and post-surgery evolution. Content is split into three distinct parts for ease of reference, including an overview of aortic pathology, diagnostic evaluations methods, and treatments. Also included are guidelines and future research directions, making this a must-have volume for all cardiologists and cardiovascular surgeons who address significant issues in this topic area. - Present pathophysiological sequences that are shown in correlation with histological details - Includes detailed clinical examinations and the value of the initial assessment using chest X-ray, echocardiography, angiography, CT angiography and magnetic resonance, etc. - Provides conventional descriptions of surgical techniques that are entirely detailed, along with long-term results and possible complications

Iatrogenesis is the occurrence of untoward effects resulting from actions of health care providers, including medical errors, medical malpractice, practicing beyond one's expertise, adverse effects of medication, unnecessary treatment, inappropriate screenings, and surgical errors. This is a huge public health issue: tens to hundreds of thousands of deaths are attributed to iatrogenic causes each year in the U.S., and vulnerable populations such as the elderly and minorities are particularly susceptible. Edited by two renowned cardiology experts, Iatrogenicity: Causes and Consequences of Iatrogenesis in Cardiovascular Medicine addresses both the iatrogenicity that arises with cardiovascular interventions, as well as non-cardiovascular interventions that result in adverse consequences on the cardiovascular system. The book aims to achieve three things: to summarize the available information on this topic in a single high-yield volume; to highlight the human and financial cost of iatrogenesis; and to describe and propose potential interventions to ameliorate the effects of iatrogenesis. This accessible book is a practical reference for any practicing physician who sees patients with cardiovascular issues..

Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society – splitting the atom, space travel, telecommunications, and the Internet – but with medical research focused mostly on science for the sake of science, it has yielded precious few cures. A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease represents a'first of its kind'effort to address both the reasons for this and to posit solutions to fix our broken system, in an effort to finally end this cure crisis. Dr. Marangos draws on 45 years of experience in every aspect of the biomedical R&D field, from basic drug discovery research at the NIH to the co-founding of five drug companies. He has published 252 research papers and edited four books on drug discovery, is co-inventor on 14 patents, and founded'The Journal of Molecular Neuroscience'. He argues that from a development perspective, the regulatory, patent, and legal hurdles that force industry to pursue so-called'me-too'drugs rather than cures for terminal diseases must be re-thought. Leadership accountability, strategy, focus, and urgency need to be re-evaluated, and major reforms to the NIH, FDA, and patent codes are proposed.to remedy these impediments to cures. Written for anyone frustrated with the seemingly endless threat of terminal disease, this book seeks to inform, energize, and provide the rationale for the public and industry stakeholders, as well as clinicians and researchers, to resurrect the physician-patient relationship and demand that we get serious about ridding society of this scourge on humanity. This work contains the views and opinions of the author and are in no way intended to harm the reputation of any person, agency, organization, or commercial entity discussed herein. www.cureterminaldisease.com - First comprehensive analysis of the failures in curing cancer, Alzheimer's, and cardiovascular disease with solutions proposed - Defines deficiencies in academic life science research, including conflicting incentives, QA/QC issues, and how to fix them - Provides a rationale for FDA reform especially as it relates to terminal disease drugs - Details how a reformed NIH, regulators, and industry can partner to form a NASA-type effort to speed cures of terminal diseases - Provides the first detailed roadmap for life science researchers to conquer terminal disease

Expert guidance from internationally recognized authorities, who provide clear and current updates on all aspects of interventional cardiology. This new edition; Contains a radically expanded chapter contents list presented in four clear sections; coronary interventions, interventional pharmacology, structural heart interventions, and endovascular therapy Includes 46 new chapters, including the latest advances in bioresorbable coronary stents, advanced transcatheter aortic valve replacement, MitraClip, new transcatheter mitral valve interventions, and more Chapters are templated for rapid referral, beginning with pathophysiological background and relevant pathology, moving to mechanisms of treatment, device description, procedural techniques, follow-up care, and ending with risks, contraindications and complications Multiple choice questions at the end of each chapter for self-assessment, a total of more than 400 MCQs in the book Features 19 procedural videos, hosted on a companion website

This book describes a wide range of interventional procedures currently employed in the treatment of cardiac diseases in women with the aim of enabling not only interventional cardiologists but also cardiologists and cardiac surgeons to refine their approach to female patients and thus improve outcomes. The book reflects the increasing awareness of gender differences with regard to coronary artery disease and structural valve heart disease. Examples include myocardial infarction, which carries a worse prognosis in women in part because they suffer from this disease mostly in the 7th decade of life, present more frequently with hemodynamic instability and later from symptom onset, and have fragile, small and tortuous coronary arteries that are more technically demanding in the context of primary percutaneous coronary intervention. Another example is symptomatic aortic stenosis, which carries a better prognosis in women who undergo trans-catheter aortic valve implantation partially due to a better annulus-prosthesis match, which leads to less residual paravalvular regurgitation, better left ventricular function and lower aggregation of comorbidities. Further, in women left ventricular response to aortic stenosis is typified by muscle hypertrophy with a small ventricular cavity. These differences are reflected in the clinical manifestations and their impact on diagnosis, treatment, and choice of tools and devices for use in interventional procedures. By explaining the at times subtle variances in disease and treatment techniques for female and male patients, this book will help practitioners select the most appropriate procedures and materials in a range of settings.

The idea of using beta-blockers as a treatment for ventricular fibrillation occurred to James Black over 60 years ago. He developed propranolol and cimetidine, among other pharmacologic agents, work for which he won the Nobel Prize in 1988. Beta-blockers were reported to lower blood pressure by Brian Pritchard in 1964, and he and John Cruickshank wrote Beta-blockers in Clinical Practice, a major early text on the subject, shortly thereafter in 1967. The role of beta-blockers has expanded over the years, as they have demonstrated their efficacy for treating several conditions affecting cardiovascular health. This booklet, The Beta-Blocker Story, offers an update on the role of beta-blockers in cardiovascular medicine. KEY FEATURES The role of beta-blockers is reviewed in the treatment of the following conditions: Ischemic heart disease Post-myocardial infarction Heart failure Dysrhythmias Hypertension

This guide is an essential tool to aid the clinician in the efficient management of adult patients with disorders of the heart and blood vessels. The content is designed for use by all health professionals caring for persons with cardiovascular conditions, ranging from the most common, such as systemic arterial hypertension and atrial fibrillation, to the most rare conditions, such as Brugada Syndrome and atrial giant cell myocarditis. The pages are rich in information that will aid both cardiovascular specialists as well as primary care/family medicine physicians and nurse practitioners, whose practices are composed of up to 50% of patients with at least one form of cardiovascular disease. In this book, the author has collated current diagnostic criteria for all primary adult cardiovascular disorders. The book assists as a point of care reference by combining established principles of disease management protocols with effective differential diagnosis algorithms.Unlike traditional books, Clinical Guide to Cardiovascular Disease is specifically designed for rapid access to disease information, segregated into keyword data elements organized under 20 separate headings relevant to clinical care. In addition, external links to key articles, Guidelines, patient information, and supplemental and updated information are provided for every condition.

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. - Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials - Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis - Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI - Covers the prevailing opinions on how to harness the body's natural repair mechanisms - Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Patients with complex cardiovascular problems pose a special management challenge for both the specialist and the non-specialist. This book helps you approach difficult cases with the confidence to strategically map care, understand the risk profile of your patient, and make effective treatment decisions. Dependable and succinct content provides high yield information for the busy cardiologist Take home call outs, and critical thinking boxes provide candid advice on incorporating guidelines and evidence based medicine into your practice New convenient pocket-sized format New chapter addressing cardiovascular problems in women Discussion of high risk factors for and strategic care mapping encourage clinical focus Clinical pearls offer expert advice on topical issues Includes emerging trends and clinical trials keeping you up to date

Cardiovascular diseases are the leading cause of death in almost 40% of patients suffering from end stage renal disease (ESRD). Cardiomyopathy and ischemic heart disease are the most frequent causes of cardiac death. The risk of cardiovascular mortality in dialysis patients is 10 to 20 times greater than the general population, particularly in younger patients, taking into account that the relative risk decreases with age. Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in chronic kidney disease (CKD), and the survival risk ratio in such patients is independent. This book examines the molecular mechanisms, treatments and clinical implication of cardiac remodeling. The first chapter discusses risk factors for cardiovascular disease in patients on continuous ambulatory peritoneal dialysis. The following chapters examine the impacts tropomyosin, vitamin D, and coffee have on cardiac remodeling.

Focusing on the interdisciplinary team, this cardiovascular resource provides evidence-based knowledge and guidance for advanced practice nurses in a variety of care settings. Its clinically relevant and directly applicable information is presented in an accessible and well-organized format. The book encompasses clinical findings, diagnostic testing, state-of-the-art procedures, and therapeutic interventions commonly utilized in inpatient and outpatient clinical cardiology. It is specifically designed to meet the informational needs of advanced practice registered nurse providers and students including family nurse practitioners, adult-gerontology acute care nurse practitioners, nurse anesthetists, and clinical nurse specialists.The resource covers the range of cardiovascular conditions, both chronic and acute. It discusses the interdisciplinary cardiovascular care team; explains the cardiovascular history and clinical examination in nearly step-by-step detail; analyzes clinical findings; details common stable and urgent conditions; describes the preoperative cardiovascular evaluation; advises on the selection and appropriateness of laboratory evaluations and cardiovascular diagnostic studies; provides an overview of state-of-the-art procedures, including electrophysiology; and assesses therapeutic interventions, including lifestyle, pharmacotherapeutics, and invasive techniques. It supports the development of clinical judgment skills and therapeutic decision-making by considering the challenges presented through advances in technology and the increasing complexity of diagnostic procedures. An appendix features tables of relevant and essential cardiovascular guidelines for quick reference.Key Features: Details current and cutting-edge practices and contemporary issues in cardiovascular care Applies evidenced-based research findings to clinical practice Compares diagnostic testing options and therapeutic interventions Clarifies complex topics through use of tables, algorithms, images, and lists Identifies pertinent studies and resources for cardiovascular care Describes common cardiac procedures and screening methods Supports the development of clinical judgment skills and therapeutic decision-making

Eureka: Cardiovascular Medicine is an innovative book for medical students that fully integrates core science, clinical medicine and surgery. The book benefits from an engaging and authoritative text, written by specialists in the field, and has several key features to help you really understand the subject: Chapter starter questions - to get you thinking about the topic before you start reading Break out boxes which contain essential key knowledge Clinical cases to help you understand the material in a clinical context Unique graphic narratives which are especially useful for visual learners End of chapter answers to the starter questions A final self-assessment chapter of Single Best Answers to really help test and reinforce your knowledge The book starts with the First Principles chapter which clearly explains the key concepts, processes and structures of the cardiovascular system. This is followed by a Clinical Essentials chapter which provides an overview of the symptoms and signs of cardiovascular disease, relevant history and examination techniques, investigations and management options. The Disease-based chapters give concise descriptions of all major disorders, e.g. ischaemic heart disease, hypertension and heart failure, each chapter introduced by engaging clinical cases that feature unique graphic narratives. The Emergencies chapter covers the principles of immediate care in situations such as cardiac arrest and acute MI. An Integrated care chapter discusses strategies for the management of chronic conditions across primary and other care settings Finally, the Self-Assessment chapter comprises 80 multiple choice questions in clinical Single Best Answer format, to thoroughly test your understanding of the subject. The Eureka series of books are designed to be a'one stop shop': they contain all the key information you need to know to succeed in your studies and pass your exams.

Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete picture of drug discovery for these conditions. The main three sections comprehensively discuss obesity, hypertension and cardiovascular disease, and diabetes in turn, following an introduction to the molecular links between them. The final chapter provides perspectives on future directions of the field. Chapters are contributed by leaders in the field from academia and industry and cover biomarkers, risk factors, gene-environment interactions, therapies and the various types of animal models that have been used to study each disease. Case studies describing the implementation of animal models in drug development further enhance the book's usefulness as a comprehensive guide to this important therapeutic area.Providing a full picture of the various types of animal models that have been used to study obesity, hypertension, and insulin resistance with recent case studies, this book provides a valuable resource for medicinal chemists and clinicians working in these disease areas.

​​Since the introduction of laser devices to the medical sciences this technology has created great interest. Specifically, the laser's unique physical properties and precise bio-tissue interactions render this versatile source of biologic energy an attractive tool for multiple therapeutic purposes in cardiovascular medicine. Over the course of the last 2 decades the utilization of laser technology has become an important component for the management of patients with complex cardiovascular diseases. During this time period, cutting edge laser technology including a variety of wave length generators, newly designed catheters, and a selection of advanced optic fibers have been introduced and applied in the cardiovascular circulation. Improved lasing techniques in the cardiac catheterization suites and operation rooms have been implemented for treatment of ischemic coronary syndromes, peripheral arterial occlusive disease and other atherosclerotic thrombotic conditions. Moreover, duringthis 20 year time frame, several multicenter and single center clinical studies have been published focusing on the role and utilization of lasers in coronary and peripheral revascularization. And within the rapidly expanding field of interventional cardiac electrophysiology, laser technology has recently revolutionized the management of fractured, abandoned and malfunctioning leads of cardiac pacemakers and automatic defibrillators. Consequently, replacing a notoriously cumbersome and high risk open heart surgery with safe and markedly efficient percutaneous laser based extraction. This textbook will provide the most authoritative, comprehensive and contemporary information covering technological progress, clinical experience and pertinent aspects of laser applications in cardiovascular medicine. It will be of interest to cardiologists, vascular surgeons and interventional radiologist as well as medical students, scientists, biomedical engineering students and graduates.​