Search

Your search keyword '"Cardenas-Blanco, Arturo"' showing total 200 results
Start Over Author "Cardenas-Blanco, Arturo"
200 results on '"Cardenas-Blanco, Arturo"'

1. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Author

Betts, Matthew J, Kirilina, Evgeniya, Otaduy, Maria CG, Ivanov, Dimo, Acosta-Cabronero, Julio, Callaghan, Martina F, Lambert, Christian, Cardenas-Blanco, Arturo, Pine, Kerrin, Passamonti, Luca, Loane, Clare, Keuken, Max C, Trujillo, Paula, Lüsebrink, Falk, Mattern, Hendrik, Liu, Kathy Y, Priovoulos, Nikos, Fliessbach, Klaus, Dahl, Martin J, Maaß, Anne, Madelung, Christopher F, Meder, David, Ehrenberg, Alexander J, Speck, Oliver, Weiskopf, Nikolaus, Dolan, Raymond, Inglis, Ben, Tosun, Duygu, Morawski, Markus, Zucca, Fabio A, Siebner, Hartwig R, Mather, Mara, Uludag, Kamil, Heinsen, Helmut, Poser, Benedikt A, Howard, Robert, Zecca, Luigi, Rowe, James B, Grinberg, Lea T, Jacobs, Heidi IL, Düzel, Emrah, and Hämmerer, Dorothea

Subjects
Locus Coeruleus, Humans, Neurodegenerative Diseases, Norepinephrine, Magnetic Resonance Imaging, Biomarkers, locus coeruleus, magnetic resonance imaging, neurodegeneration, noradrenaline (NA) biomarker, noradrenaline, biomarker, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer's disease, atypical neurodegenerative dementias and Parkinson's disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.

Published
2019

2. Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia

Author

Malo Gaubert, Andrea Dell’Orco, Catharina Lange, Antoine Garnier-Crussard, Isabella Zimmermann, Martin Dyrba, Marco Duering, Gabriel Ziegler, Oliver Peters, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Emrah Düzel, Frank Jessen, Miranka Wirth, for the DELCODE study group, Amthauer Holger, Cetindag Arda Can, Cosma Nicoleta Carmen, Diesing Dominik, Ehrlich Marie, Fenski Frederike, Freiesleben Silka Dawn, Fuentes Manuel, Hauser Dietmar, Hujer Nicole, Incesoy Enise Irem, Kainz Christian, Lange Catharina, Lindner Katja, Megges Herlind, Peters Oliver, Preis Lukas, Altenstein Slawek, Lohse Andrea, Franke Christiana, Priller Josef, Spruth Eike, Villar Munoz Irene, Barkhoff Miriam, Boecker Henning, Brosseron Frederic, Daamen Marcel, Engels Tanja, Faber Jennifer, Fließbach Klaus, Frommann Ingo, Grobe-Einsler Marcus, Hennes Guido, Herrmann Gabi, Jost Lorraine, Kalbhen Pascal, Kimmich Okka, Kobeleva Xenia, Kofler Barbara, McCormick Cornelia, Miebach Lisa, Miklitz Carolin, Müller Anna, Oender Demet, Polcher Alexandra, Purrer Veronika, Röske Sandra, Schneider Christine, Schneider Anja, Spottke Annika, Vogt Ina, Wagner Michael, wolfsgruber Steffen, Yilmaz Sagik, Bartels Claudia, Dechent Peter, Hansen Niels, Hassoun Lina, Hirschel Sina, Nuhn Sabine, Pfahlert Ilona, Rausch Lena, Schott Björn, Timäus Charles, Werner Christine, Wiltfang Jens, Zabel Lioba, Zech Heike, Bader Abdelmajid, Baldermann Juan Carlos, Dölle Britta, Drzezga Alexander, Escher Claus, Ghiasi Nasim Roshan, Hardenacke Katja, Jessen Frank, Lützerath Hannah, Maier Franziska, Marquardt Benjamin, Martikke Anja, Meiberth Dix, Petzler Snjezana, Rostamzadeh Ayda, Sannemann Lena, Schild Ann-Katrin, Sorgalla Susanne, Stockter Simone, Thelen Manuela, Tscheuschler Maike, Uhle Franziska, Zeyen Philip, Bittner Daniel, Cardenas-Blanco Arturo, Dobisch Laura, Düzel Emrah, Grieger-Klose Doreen, Hartmann Deike, Metzger Coraline, Nestor Peter, Ruß Christin, Schulze Franziska, Speck Oliver, Yakupov Renat, Ziegler Gabriel, Brauneis Christine, Bürger Katharina, Catak Cihan, Coloma Andrews Lisa, Dichgans Martin, Dörr Angelika, Ertl-Wagner Birgit, Frimmer Daniela, Huber Brigitte, Janowitz Daniel, Kreuzer Max, Markov Eva, Müller Claudia, Rominger Axel, Schmid (ehemals Spreider) Jennifer, Seegerer Anna, Stephan Julia, Zollver Adelgunde, Burow Lena, de Jonge Sylvia, Falkai Peter, Garcia Angarita Natalie, Görlitz Thomas, Gürsel Selim Üstün, Horvath Ildiko, Kurz Carolin, Meisenzahl-Lechner Eva, Perneczky Robert, Utecht Julia, Dyrba Martin, Janecek-Meyer Heike, Kilimann Ingo, Lappe Chris, Lau Esther, Pfaff Henrike, Raum Heike, Sabik Petr, Schmidt Monika, Schulz Heike, Schwarzenboeck Sarah, Teipel Stefan, Weber Marc-Andre, Buchmann Martina, Heger Tanja, Hinderer Petra, Kuder-Buletta Elke, Laske Christoph, Munk Matthias, Mychajliw Christian, Soekadar Surjo, sulzer Patricia, and Trunk Theresia

Subjects
white matter hyperintensities segmentation, evaluation, FLAIR, deep learning, aging, Alzheimer’s disease, Psychiatry, RC435-571
Abstract

BackgroundWhite matter hyperintensities (WMH), a biomarker of small vessel disease, are often found in Alzheimer’s disease (AD) and their advanced detection and quantification can be beneficial for research and clinical applications. To investigate WMH in large-scale multicenter studies on cognitive impairment and AD, appropriate automated WMH segmentation algorithms are required. This study aimed to compare the performance of segmentation tools and provide information on their application in multicenter research.MethodsWe used a pseudo-randomly selected dataset (n = 50) from the DZNE-multicenter observational Longitudinal Cognitive Impairment and Dementia Study (DELCODE) that included 3D fluid-attenuated inversion recovery (FLAIR) images from participants across the cognitive continuum. Performances of top-rated algorithms for automated WMH segmentation [Brain Intensity Abnormality Classification Algorithm (BIANCA), lesion segmentation toolbox (LST), lesion growth algorithm (LGA), LST lesion prediction algorithm (LPA), pgs, and sysu_media] were compared to manual reference segmentation (RS).ResultsAcross tools, segmentation performance was moderate for global WMH volume and number of detected lesions. After retraining on a DELCODE subset, the deep learning algorithm sysu_media showed the highest performances with an average Dice’s coefficient of 0.702 (±0.109 SD) for volume and a mean F1-score of 0.642 (±0.109 SD) for the number of lesions. The intra-class correlation was excellent for all algorithms (>0.9) but BIANCA (0.835). Performance improved with high WMH burden and varied across brain regions.ConclusionTo conclude, the deep learning algorithm, when retrained, performed well in the multicenter context. Nevertheless, the performance was close to traditional methods. We provide methodological recommendations for future studies using automated WMH segmentation to quantify and assess WMH along the continuum of cognitive impairment and AD dementia.

Published
2023
Full Text
View/download PDF

3. Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment

Author

Bainbridge, Wilma A., Berron, David, Schütze, Hartmut, Cardenas-Blanco, Arturo, Metzger, Coraline, Dobisch, Laura, Bittner, Daniel, Glanz, Wenzel, Spottke, Annika, Rudolph, Janna, Brosseron, Frederic, Buerger, Katharina, Janowitz, Daniel, Fliessbach, Klaus, Heneka, Michael, Laske, Christoph, Buchmann, Martina, Peters, Oliver, Diesing, Dominik, Li, Siyao, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Kofler, Barbara, Teipel, Stefan, Kilimann, Ingo, Wiltfang, Jens, Bartels, Claudia, Wolfsgruber, Steffen, Wagner, Michael, Jessen, Frank, Baker, Chris I., and Düzel, Emrah

Published
2019
Full Text
View/download PDF

4. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Author

Düzel, Emrah, Acosta-Cabronero, Julio, Berron, David, Biessels, Geert Jan, Björkman-Burtscher, Isabella, Bottlaender, Michel, Bowtell, Richard, Buchem, Mark v, Cardenas-Blanco, Arturo, Boumezbeur, Fawzi, Chan, Dennis, Clare, Stuart, Costagli, Mauro, de Rochefort, Ludovic, Fillmer, Ariane, Gowland, Penny, Hansson, Oskar, Hendrikse, Jeroen, Kraff, Oliver, Ladd, Mark E., Ronen, Itamar, Petersen, Esben, Rowe, James B., Siebner, Hartwig, Stoecker, Tony, Straub, Sina, Tosetti, Michela, Uludag, Kamil, Vignaud, Alexandre, Zwanenburg, Jaco, and Speck, Oliver

Published
2019
Full Text
View/download PDF

6. Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding

Author

Maass, Anne, Schütze, Hartmut, Speck, Oliver, Yonelinas, Andrew, Tempelmann, Claus, Heinze, Hans-Jochen, Berron, David, Cardenas-Blanco, Arturo, Brodersen, Kay H, Enno Stephan, Klaas, and Düzel, Emrah

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Information and Computing Sciences, Psychology, Machine Learning, Mental Health, Neurosciences, 1.2 Psychological and socioeconomic processes, 1.1 Normal biological development and functioning, Underpinning research, Mental health, Neurological, Adult, Entorhinal Cortex, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Neural Pathways, Radiography, Young Adult
Abstract

The ability to form long-term memories for novel events depends on information processing within the hippocampus (HC) and entorhinal cortex (EC). The HC-EC circuitry shows a quantitative segregation of anatomical directionality into different neuronal layers. Whereas superficial EC layers mainly project to dentate gyrus (DG), CA3 and apical CA1 layers, HC output is primarily sent from pyramidal CA1 layers and subiculum to deep EC layers. Here we utilize this directionality information by measuring encoding activity within HC/EC subregions with 7 T high resolution functional magnetic resonance imaging (fMRI). Multivariate Bayes decoding within HC/EC subregions shows that processing of novel information most strongly engages the input structures (superficial EC and DG/CA2-3), whereas subsequent memory is more dependent on activation of output regions (deep EC and pyramidal CA1). This suggests that while novelty processing is strongly related to HC-EC input pathways, the memory fate of a novel stimulus depends more on HC-EC output.

Published
2014

8. CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Author

Düzel, Emrah, Berron, David, Schütze, Hartmut, Cardenas-Blanco, Arturo, Metzger, Coraline, Betts, Matthew, Ziegler, Gabriel, Chen, Yi, Dobisch, Laura, Bittner, Daniel, Glanz, Wenzel, Reuter, Martin, Spottke, Annika, Rudolph, Janna, Brosseron, Frederic, Buerger, Katharina, Janowitz, Daniel, Fliessbach, Klaus, Heneka, Michael, Laske, Christoph, Buchmann, Martina, Nestor, Peter, Peters, Oliver, Diesing, Dominik, Li, Siyao, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Ramirez, Alfredo, Schneider, Anja, Kofler, Barbara, Speck, Oliver, Teipel, Stefan, Kilimann, Ingo, Dyrba, Martin, Wiltfang, Jens, Bartels, Claudia, Wolfsgruber, Steffen, Wagner, Michael, and Jessen, Frank

Published
2018
Full Text
View/download PDF

12. Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease

Author

Billette, Ornella V, Ziegler, Gabriel, Dahmen, Philip, Dechent, Peter, Dobisch, Laura, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Göerß, Doreen, Haynes, John Dylan, Heneka, Michael T, Kilimann, Ingo, Aruci, Merita, Kimmich, Okka, Kleineidam, Luca, Laske, Christoph, Lohse, Andrea, Rostamzadeh, Ayda, Metzger, Coraline, Munk, Matthias H, Peters, Oliver, Preis, Lukas, Priller, Josef, Schütze, Hartmut, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Ramirez, Alfredo, Röske, Sandra, Roy, Nina, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Kizilirmak, Jasmin M, Wolfsgruber, Steffen, Yakupov, Renat, Zeidman, Peter, Jessen, Frank, Schott, Björn, Düzel, Emrah, Maass, Anne, Group, DELCODE Study, Richter, Anni, Altenstein, Slawek, Bartels, Claudia, Brosseron, Frederic, and Cardenas-Blanco, Arturo

Subjects
Alzheimer Disease/diagnosis, Amyloid beta-Peptides, Cognitive Dysfunction/diagnostic imaging, diagnosis [Alzheimer Disease], diagnostic imaging [Cognitive Dysfunction], Magnetic Resonance Imaging, Temporal Lobe/diagnostic imaging, Temporal Lobe, Magnetic Resonance Imaging/methods, diagnostic imaging [Parietal Lobe], Parietal Lobe/diagnostic imaging, methods [Magnetic Resonance Imaging], diagnostic imaging [Temporal Lobe], Alzheimer Disease, Parietal Lobe, Humans, Cognitive Dysfunction, ddc:610, Neurology (clinical), Biomarkers
Abstract

Background and ObjectivesWe assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy.MethodsWe studied 499 participants aged 60–88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of β-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education.ResultsIn the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers.DiscussionNovelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.

Published
2022
Full Text
View/download PDF

13. A Cognitive Reserve Network That Moderates the Relationship Between Alzheimer’s Disease Pathology and Cognition

Author

Vockert, Niklas, primary, Schütze, Hartmut, additional, Richter, Anni, additional, Altenstein, Slawek, additional, Bartels, Claudia, additional, Brosseron, Frederic, additional, Cardenas‐Blanco, Arturo, additional, Dahmen, Philip, additional, Dechent, Peter, additional, Dobisch, Laura, additional, Fließbach, Klaus, additional, Freiesleben, Silka Dawn, additional, Glanz, Wenzel, additional, Goerss, Doreen, additional, Haynes, John‐Dylan, additional, Heneka, Michael T., additional, Kilimann, Ingo, additional, Kimmich, Okka, additional, Kleineidam, Luca, additional, Laske, Christoph, additional, Lohse, Andrea, additional, Metzger, Coraline D., additional, Munk, Matthias H. J., additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Ramirez, Alfredo, additional, Roeske, Sandra, additional, Rostamzadeh, Ayda, additional, Roy, Nina, additional, Scheffler, Klaus, additional, Schneider, Anja, additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, Wagner, Michael, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Yakupov, Renat, additional, Zeidman, Peter, additional, Jessen, Frank, additional, Schott, Björn H, additional, Duzel, Emrah, additional, Maass, Anne, additional, and Ziegler, Gabriel, additional

Published
2022
Full Text
View/download PDF

14. Amyloid pathology but not APOE epsilon 4 status is permissive for tau-related hippocampal dysfunction

Author

Duezel, Emrah, Ziegler, Gabriel, Berron, David, Maass, Anne, Schuetze, Hartmut, Cardenas-Blanco, Arturo, Glanz, Wenzel, Metzger, Coraline, Dobisch, Laura, Reuter, Martin, Spottke, Annika, Brosseron, Frederic, Fliessbach, Klaus, Heneka, Michael T., Laske, Christoph, Peters, Oliver, Priller, Josef, Spruth, Eike Jakob, Ramirez, Alfredo, Speck, Oliver, Schneider, Anja, Teipel, Stefan, Kilimann, Ingo, Jens, Wiltfang, Schott, Bjoern-Hendrik, Preis, Lukas, Gref, Daria, Maier, Franziska, Munk, Matthias H., Roy, Nina, Ballarini, Tomasso, Yakupov, Renat, Haynes, John Dylan, Dechent, Peter, Scheffler, Klaus, Wagner, Michael, Jessen, Frank, Duezel, Emrah, Ziegler, Gabriel, Berron, David, Maass, Anne, Schuetze, Hartmut, Cardenas-Blanco, Arturo, Glanz, Wenzel, Metzger, Coraline, Dobisch, Laura, Reuter, Martin, Spottke, Annika, Brosseron, Frederic, Fliessbach, Klaus, Heneka, Michael T., Laske, Christoph, Peters, Oliver, Priller, Josef, Spruth, Eike Jakob, Ramirez, Alfredo, Speck, Oliver, Schneider, Anja, Teipel, Stefan, Kilimann, Ingo, Jens, Wiltfang, Schott, Bjoern-Hendrik, Preis, Lukas, Gref, Daria, Maier, Franziska, Munk, Matthias H., Roy, Nina, Ballarini, Tomasso, Yakupov, Renat, Haynes, John Dylan, Dechent, Peter, Scheffler, Klaus, Wagner, Michael, and Jessen, Frank

Abstract

We investigated whether the impact of tau-pathology on memory performance and on hippocampal/medial temporal memory function in non-demented individuals depends on the presence of amyloid pathology, irrespective of diagnostic clinical stage. We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). Two hundred and thirty-five participants completed task functional MRI and provided CSF (92 cognitively unimpaired, 100 experiencing subjective cognitive decline and 43 with mild cognitive impairment). Presence (A+) and absence (A-) of amyloid pathology was defined by CSF amyloid-beta(42) (A beta 42) levels. Free recall performance in the Free and Cued Selective Reminding Test, scene recognition memory accuracy and hippocampal/medial temporal functional MRI novelty responses to scene images were related to CSF total-tau and phospho-tau levels separately for A+ and A- individuals. We found that total-tau and phospho-tau levels were negatively associated with memory performance in both tasks and with novelty responses in the hippocampus and amygdala, in interaction with A beta 42 levels. Subgroup analyses showed that these relationships were only present in A+ and remained stable when very high levels of tau (>700 pg/ml) and phospho-tau (>100 pg/ml) were excluded. These relationships were significant with diagnosis, age, education, sex, assessment site and A beta 42 levels as covariates. They also remained significant after propensity score based matching of phospho-tau levels across A+ and A- groups. After classifying this matched sample for phospho-tau pathology (T-/T+), individuals with A+/T+ were significantly more memory-impaired than A-/T+ despite the fact that both groups had the same amount of phospho-tau pathology. ApoE status (presence of the E4 allele), a known genetic risk factor for Alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal fun

Published
2022

15. Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease

Author

Billette, Ornella, V, Ziegler, Gabriel, Aruci, Merita, Schuetze, Hartmut, Kizilirmak, Jasmin M., Richter, Anni, Altenstein, Slawek, Bartels, Claudia, Brosseron, Frederic, Cardenas-Blanco, Arturo, Dahmen, Philip, Dechent, Peter, Dobisch, Laura, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Goeerss, Doreen, Haynes, John Dylan, Heneka, Michael T., Kilimann, Ingo, Kimmich, Okka, Kleineidam, Luca, Laske, Christoph, Lohse, Andrea, Rostamzadeh, Ayda, Metzger, Coraline, Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Zeidman, Peter, Jessen, Frank, Schott, Bjorn H., Duezel, Emrah, Maass, Anne, Billette, Ornella, V, Ziegler, Gabriel, Aruci, Merita, Schuetze, Hartmut, Kizilirmak, Jasmin M., Richter, Anni, Altenstein, Slawek, Bartels, Claudia, Brosseron, Frederic, Cardenas-Blanco, Arturo, Dahmen, Philip, Dechent, Peter, Dobisch, Laura, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Goeerss, Doreen, Haynes, John Dylan, Heneka, Michael T., Kilimann, Ingo, Kimmich, Okka, Kleineidam, Luca, Laske, Christoph, Lohse, Andrea, Rostamzadeh, Ayda, Metzger, Coraline, Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Zeidman, Peter, Jessen, Frank, Schott, Bjorn H., Duezel, Emrah, and Maass, Anne

Abstract

Background and Objectives We assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy. Methods We studied 499 participants aged 60-88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of beta-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education. Results In the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the pre

Published
2022

17. Amyloid pathology but notAPOEε4 status is permissive for tau-related hippocampal dysfunction

Author

Düzel, Emrah, primary, Ziegler, Gabriel, additional, Berron, David, additional, Maass, Anne, additional, Schütze, Hartmut, additional, Cardenas-Blanco, Arturo, additional, Glanz, Wenzel, additional, Metzger, Coraline, additional, Dobisch, Laura, additional, Reuter, Martin, additional, Spottke, Annika, additional, Brosseron, Frederic, additional, Fliessbach, Klaus, additional, Heneka, Michael T, additional, Laske, Christoph, additional, Peters, Oliver, additional, Priller, Josef, additional, Spruth, Eike Jakob, additional, Ramirez, Alfredo, additional, Speck, Oliver, additional, Schneider, Anja, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Jens, Wiltfang, additional, Schott, Björn-Hendrik, additional, Preis, Lukas, additional, Gref, Daria, additional, Maier, Franziska, additional, Munk, Matthias H, additional, Roy, Nina, additional, Ballarini, Tomasso, additional, Yakupov, Renat, additional, Haynes, John Dylan, additional, Dechent, Peter, additional, Scheffler, Klaus, additional, Wagner, Michael, additional, and Jessen, Frank, additional

Published
2022
Full Text
View/download PDF

19. A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis

Author

Müller, Hans-Peter, Turner, Martin R, Grosskreutz, Julian, Abrahams, Sharon, Bede, Peter, Govind, Varan, Prudlo, Johannes, Ludolph, Albert C, Filippi, Massimo, Kassubek, Jan, Abdulla, Susanne, Agosta, Federica, Ajroud-Driss, Senda, Atassi, Nazem, Bastin, Mark, Benatar, Michael, Brooks, William, Calvo, Andrea, Cardenas-Blanco, Arturo, Chio, Adriano, De Carvalho, Mamede, Dahnke, Robert, Enzinger, Christian, Ferraro, Pilar Maria, Floeter, Mary Kay, Foerster, Bradley, Gaser, Christian, Geraldo, Ana Filipa, Gorges, Martin, Grehl, Torsten, Groen, Georg, Hardiman, Orla, Hartung, Viktor, Jelsone-Swain, Laura, Jenkins, Tom, Kalra, Sanjay, Kasper, Elisabeth, Kitzler, Hagen, Koritnik, Blaz, Kuzma–Kozakiewicz, Magdalena, LaFleur, Karl, Lulé, Dorothée, Machts, Judith, Meoded, Avner, Pettit, Lewis, Euan, MacDonald, Pioro, Erik, Poletti, Barbara, Pradat, Pierre-Francois, Prell, Tino, Proudfoot, Malcolm, Ratti, Elena, Riva, Nilo, Robberecht, Wim, Ropele, Stefan, Salachas, Francois, Schmidt, Ruben, Schmidt-Wilcke, Schuster, Christina, Shaw, Pamela, Sherman, Alex, Silani, Vincenzo, Spinelli, Edoardo Gioele, Teipel, Stefan, Van Damme, Philip, Van den Berg, Leonard, Van den Heuvel, Martin, Verstraete, Esther, Walhout, Renée, Welsh, Robert, Weber, Markus, Westeneng, Henk-Jan, Wittstock, Matthias, and Yunusova, Yana

Published
2016
Full Text
View/download PDF

22. A high fMRI activation deviation score is linked to worse clinical phenotype and Aß42/40 positivity

Author

Billette, Ornella, Ziegler, Gabriel, Schütze, Hartmut, Schott, Björn, Richter, Anni, Cardenas-Blanco, Arturo, Metzger, Coraline, Bittner, Daniel, Glanz, Wenzel, Spottke, Annika, Brosseron, Frederic, Bürger, Katharine, Fliessbach, Klaus, Heneka, Michael, Laske, Christoph, Nestor, Peter J, Peters, Oliver, Priller, Josef, Pross, Verena, Ramirez, Alfredo, Schneider, Anja, Speck, Oliver, Teipel, Stefan, Wiltfang, Jens, Jessen, Frank, Maass, Anne, Düzel, Emrah, and Delcode Study Group

Published
2020
Full Text
View/download PDF

24. Lifestyle differences modulate the effects of cognitive reserve on functional connectivity

Author

Ersözlü, Ersin, primary, Rauchmann, Boris, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Wiltfang, Jens, additional, Jessen, Frank, additional, Düzel, Emrah, additional, Bürger, Katharina, additional, Teipel, Stefan J., additional, Christoph, Laske, additional, Spottke, Annika, additional, Ramirez, Alfredo, additional, Cardenas‐Blanco, Arturo, additional, Wagner, Michael, additional, and Perneczky, Robert, additional

Published
2020
Full Text
View/download PDF

25. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction.

Author

Düzel, Emrah, Ziegler, Gabriel, Berron, David, Maass, Anne, Schütze, Hartmut, Cardenas-Blanco, Arturo, Glanz, Wenzel, Metzger, Coraline, Dobisch, Laura, Reuter, Martin, Spottke, Annika, Brosseron, Frederic, Fliessbach, Klaus, Heneka, Michael T, Laske, Christoph, Peters, Oliver, Priller, Josef, Spruth, Eike Jakob, Ramirez, Alfredo, and Speck, Oliver

Subjects
PROTEINS, AMYLOIDOSIS, ALZHEIMER'S disease, NERVE tissue proteins, HIPPOCAMPUS (Brain), CROSS-sectional method, APOLIPOPROTEINS, RESEARCH funding, PEPTIDES
Abstract

We investigated whether the impact of tau-pathology on memory performance and on hippocampal/medial temporal memory function in non-demented individuals depends on the presence of amyloid pathology, irrespective of diagnostic clinical stage. We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). Two hundred and thirty-five participants completed task functional MRI and provided CSF (92 cognitively unimpaired, 100 experiencing subjective cognitive decline and 43 with mild cognitive impairment). Presence (A+) and absence (A-) of amyloid pathology was defined by CSF amyloid-β42 (Aβ42) levels. Free recall performance in the Free and Cued Selective Reminding Test, scene recognition memory accuracy and hippocampal/medial temporal functional MRI novelty responses to scene images were related to CSF total-tau and phospho-tau levels separately for A+ and A- individuals. We found that total-tau and phospho-tau levels were negatively associated with memory performance in both tasks and with novelty responses in the hippocampus and amygdala, in interaction with Aβ42 levels. Subgroup analyses showed that these relationships were only present in A+ and remained stable when very high levels of tau (>700 pg/ml) and phospho-tau (>100 pg/ml) were excluded. These relationships were significant with diagnosis, age, education, sex, assessment site and Aβ42 levels as covariates. They also remained significant after propensity score based matching of phospho-tau levels across A+ and A- groups. After classifying this matched sample for phospho-tau pathology (T-/T+), individuals with A+/T+ were significantly more memory-impaired than A-/T+ despite the fact that both groups had the same amount of phospho-tau pathology. ApoE status (presence of the E4 allele), a known genetic risk factor for Alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. Thus, our data show that the presence of amyloid pathology is associated with a linear relationship between tau pathology, hippocampal dysfunction and memory impairment, although the actual severity of amyloid pathology is uncorrelated. Our data therefore indicate that the presence of amyloid pathology provides a permissive state for tau-related hippocampal dysfunction and hippocampus-dependent recognition and recall impairment. This raises the possibility that in the predementia stage of Alzheimer's disease, removing the negative impact of amyloid pathology could improve memory and hippocampal function even if the amount of tau-pathology in CSF is not changed, whereas reducing increased CSF tau-pathology in amyloid-negative individuals may not proportionally improve memory function. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

27. In vivo visualization of age-related differences in the locus coeruleus

Author

Liu, Kathy Y, Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Loane, Clare, Berry, Alex J, Betts, Matthew J, Kievit, Rogier A, Henson, Richard N, Düzel, Emrah, Cam-CAN, Howard, Robert, and Hämmerer, Dorothea

Subjects
Adult, Aged, 80 and over, Male, Melanins, Aging, Adolescent, Noradrenergic system, Middle Aged, Magnetic Resonance Imaging, Neuromelanin, Healthy Aging, Young Adult, Cognition, Locus coeruleus, Humans, Female, Aged
Abstract

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central nervous system, may play an important role in neuropsychiatric disorders including Parkinson's disease and Alzheimer's disease. The pattern of age-related change of the LC across the life span is unclear. We obtained normalized, mean LC signal intensity values, that is, contrast ratios (CRs), from magnetization transfer-weighted images to investigate the relationship between LC CR and age in cognitively normal healthy adults (N = 605, age range 18-88 years). Study participants were part of the Cambridge Centre for Ageing and Neuroscience-an open-access, population-based data set. We found a quadratic relationship between LC CR and age, the peak occurring around 60 years, with no differences between males and females. Subregional analyses revealed that age-related decline in LC CR was confined to the rostral portion of the LC. Older adults showed greater variance in overall LC CR than younger adults, and the functional and clinical implications of these observed age-related differences require further investigation. Visualization of the LC in this study may inform how future scanning parameters can be optimized, and provides insight into how LC integrity changes across the life span.

Published
2018
Full Text
View/download PDF

28. Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer's disease based on multicenter diffusion tensor imaging

Author

Brueggen, Katharina, Dyrba, Martin, Cardenas-Blanco, Arturo, Schneider, Anja, Fliessbach, Klaus, Buerger, Katharina, Janowitz, Daniel, Peters, Oliver, Menne, Felix, Priller, Josef, Spruth, Eike, Wiltfang, Jens, Vukovich, Ruth, Laske, Christoph, Buchmann, Martina, Wagner, Michael, Roeske, Sandra, Spottke, Annika, Rudolph, Janna, Metzger, Coraline D., Kilimann, Ingo, Dobisch, Laura, Dueze, Emrah, Jessen, Frank, Teipel, Stefan J., Brueggen, Katharina, Dyrba, Martin, Cardenas-Blanco, Arturo, Schneider, Anja, Fliessbach, Klaus, Buerger, Katharina, Janowitz, Daniel, Peters, Oliver, Menne, Felix, Priller, Josef, Spruth, Eike, Wiltfang, Jens, Vukovich, Ruth, Laske, Christoph, Buchmann, Martina, Wagner, Michael, Roeske, Sandra, Spottke, Annika, Rudolph, Janna, Metzger, Coraline D., Kilimann, Ingo, Dobisch, Laura, Dueze, Emrah, Jessen, Frank, and Teipel, Stefan J.

Abstract

Introduction Subjective cognitive decline (SCD) can represent a preclinical stage of Alzheimer's disease. Diffusion tensor imaging (DTI) could aid an early diagnosis, yet only few monocentric DTI studies in SCD have been conducted, reporting heterogeneous results. We investigated microstructural changes in SCD in a larger, multicentric cohort. Methods 271 participants with SCD, mild cognitive impairment (MCI) or Alzheimer's dementia (AD) and healthy controls (CON) were included, recruited prospectively at nine centers of the observational DELCODE study. DTI was acquired using identical protocols. Using voxel-based analyses, we investigated fractional anisotropy (FA), mean diffusivity (MD) and mode (MO) in the white matter (WM). Discrimination accuracy was determined by cross-validated elastic-net penalized regression. Center effects were explored using variance analyses. Results MO and FA were lower in SCD compared to CON in several anterior and posterior WM regions, including the anterior corona radiata, superior and inferior longitudinal fasciculus, cingulum and splenium of the corpus callosum (p < 0.01, uncorrected). MD was higher in the superior and inferior longitudinal fasciculus, cingulum and superior corona radiata (p < 0.01, uncorrected). The cross-validated accuracy for discriminating SCD from CON was 67% (p < 0.01). As expected, the AD and MCI groups had higher MD and lower FA and MO in extensive regions, including the corpus callosum and temporal brain regions. Within these regions, center accounted for 3-15% of the variance. Conclusions DTI revealed subtle WM alterations in SCD that were intermediate between those in MCI and CON and may be useful to detect individuals with an increased risk for AD in clinical studies.

Published
2019

29. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults

Author

Berron, David, Cardenas-Blanco, Arturo, Bittner, Daniel, Metzger, Coraline D., Spottke, Annika, Heneka, Michael T., Fliessbach, Klaus, Schneider, Anja, Teipel, Stefan J., Wagner, Michael, Speck, Oliver, Jessen, Frank, Duezel, Emrah, Berron, David, Cardenas-Blanco, Arturo, Bittner, Daniel, Metzger, Coraline D., Spottke, Annika, Heneka, Michael T., Fliessbach, Klaus, Schneider, Anja, Teipel, Stefan J., Wagner, Michael, Speck, Oliver, Jessen, Frank, and Duezel, Emrah

Abstract

Mnemonic discrimination, the ability to distinguish similar events in memory, relies on subregions in the human medial temporal lobes (MTLs). Tau pathology is frequently found within the MTL of older adults and therefore likely to affect mnemonic discrimination, even in healthy older individuals. The MTL subregions that are known to be affected early by tau pathology, the perirhinal-transentorhinal region (area 35) and the anterior-lateral entorhinal cortex (alEC), have recently been implicated in the mnemonic discrimination of objects rather than scenes. Here we used an object-scene mnemonic discrimination task in combination with fMRI recordings and analyzed the relationship between subregional MTL activity, memory performance, and levels of total and phosphorylated tau as well as A beta 42/40 ratio in CSF. We show that activity in alEC was associated with mnemonic discrimination of similar objects but not scenes in male and female cognitively unimpaired older adults. Importantly, CSF tau levels were associated with increased fMRI activity in the hippocampus, and both increased hippocampal activity as well as tau levels were associated with mnemonic discrimination of objects, but again not scenes. This suggests that dysfunction of the alEC-hippocampus object mnemonic discrimination network might be a marker for tau-related cognitive decline.

Published
2019

30. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Author

Zorglijn AN/AAN Medisch, Brain, Circulatory Health, MS Radiologie, Researchgr. Neuroradiologie, Onderzoek Beeld, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Düzel, Emrah, Acosta-Cabronero, Julio, Berron, David, Biessels, Geert Jan, Björkman-Burtscher, Isabella, Bottlaender, Michel, Bowtell, Richard, Buchem, Mark V, Cardenas-Blanco, Arturo, Boumezbeur, Fawzi, Chan, Dennis, Clare, Stuart, Costagli, Mauro, de Rochefort, Ludovic, Fillmer, Ariane, Gowland, Penny, Hansson, Oskar, Hendrikse, Jeroen, Kraff, Oliver, Ladd, Mark E, Ronen, Itamar, Petersen, Esben, Rowe, James B, Siebner, Hartwig, Stoecker, Tony, Straub, Sina, Tosetti, Michela, Uludag, Kamil, Vignaud, Alexandre, Zwanenburg, Jaco, Speck, Oliver, Zorglijn AN/AAN Medisch, Brain, Circulatory Health, MS Radiologie, Researchgr. Neuroradiologie, Onderzoek Beeld, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Düzel, Emrah, Acosta-Cabronero, Julio, Berron, David, Biessels, Geert Jan, Björkman-Burtscher, Isabella, Bottlaender, Michel, Bowtell, Richard, Buchem, Mark V, Cardenas-Blanco, Arturo, Boumezbeur, Fawzi, Chan, Dennis, Clare, Stuart, Costagli, Mauro, de Rochefort, Ludovic, Fillmer, Ariane, Gowland, Penny, Hansson, Oskar, Hendrikse, Jeroen, Kraff, Oliver, Ladd, Mark E, Ronen, Itamar, Petersen, Esben, Rowe, James B, Siebner, Hartwig, Stoecker, Tony, Straub, Sina, Tosetti, Michela, Uludag, Kamil, Vignaud, Alexandre, Zwanenburg, Jaco, and Speck, Oliver

Published
2019

31. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults

Author

Berron, David, primary, Cardenas-Blanco, Arturo, additional, Bittner, Daniel, additional, Metzger, Coraline D., additional, Spottke, Annika, additional, Heneka, Michael T., additional, Fliessbach, Klaus, additional, Schneider, Anja, additional, Teipel, Stefan J., additional, Wagner, Michael, additional, Speck, Oliver, additional, Jessen, Frank, additional, and Düzel, Emrah, additional

Published
2019
Full Text
View/download PDF

32. Memorability of photographs in subjective cognitive decline and mild cognitive impairment: implications for cognitive assessment

Author

Bainbridge, Wilma A., primary, Berron, David, additional, Schütze, Hartmut, additional, Cardenas-Blanco, Arturo, additional, Metzger, Coraline, additional, Dobisch, Laura, additional, Bittner, Daniel, additional, Glanz, Wenzel, additional, Spottke, Annika, additional, Rudolph, Janna, additional, Brosseron, Frederic, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Fliessbach, Klaus, additional, Heneka, Michael, additional, Laske, Christoph, additional, Buchmann, Martina, additional, Peters, Oliver, additional, Diesing, Dominik, additional, Li, Siyao, additional, Priller, Josef, additional, Spruth, Eike Jakob, additional, Altenstein, Slawek, additional, Schneider, Anja, additional, Kofler, Barbara, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Wiltfang, Jens, additional, Bartels, Claudia, additional, Wolfsgruber, Steffen, additional, Wagner, Michael, additional, Jessen, Frank, additional, Baker, Chris, additional, and Düzel, Emrah, additional

Published
2019
Full Text
View/download PDF

33. F1‐04‐02: ASSOCIATION BETWEEN NEURAL NOVELTY RESPONSES AND CSF BIOMARKERS OF ALZHEIMER'S DISEASE: ANATOMICAL SPECIFICITY AND DEPENDENCE ON ATROPHY

Author

Düzel, Emrah, primary, Berron, David, additional, Cardenas-Blanco, Arturo, additional, Metzger, Coraline D., additional, Bittner, Daniel, additional, Spottke, Annika, additional, Buerger, Katharina, additional, Fliessbach, Klaus, additional, Heneka, Michael, additional, Nestor, Peter, additional, Laske, Christoph, additional, Peters, Oliver, additional, Priller, Josef, additional, Schneider, Anja, additional, Speck, Oliver, additional, Teipel, Stefan J., additional, Wagner, Michael, additional, and Jessen, Frank, additional

Published
2018
Full Text
View/download PDF

34. P1‐449: MAPPING AMYLOID DEPOSITION ON CORTICAL ATROPHY IN DOWN SYNDROME: A COMBINED BASELINE AND 2‐YEAR LONGITUDINAL ANALYSIS

Author

Mak, Elijah, primary, Padilla, Concepcion, additional, Annus, Tiina, additional, Wilson, Liam, additional, Hong, Young T., additional, Acosta-Cabronero, Julio, additional, Fryer, Tim D., additional, Cardenas-Blanco, Arturo, additional, Boros, Istvan, additional, Coles, Jonathon P., additional, Aigbirhio, Franklin I., additional, Menon, David K., additional, Nestor, Peter, additional, Zaman, Shahid, additional, and Holland, Anthony J., additional

Published
2018
Full Text
View/download PDF

35. F4‐07‐03: RELATIONSHIP BETWEEN LOCUS COERULEUS MRI CONTRAST, COGNITION AND CSF BIOMARKERS IN AGING AND ALZHEIMER'S DISEASE

Author

Betts, Matthew J., primary, Cardenas-Blanco, Arturo, additional, Kanowski, Martin, additional, Wagner, Michael, additional, Heneka, Michael, additional, Spottke, Annika, additional, Teipel, Stefan J., additional, Schneider, Anja, additional, Oliver, Peters, additional, Priller, Josef, additional, Wiltfang, Jens, additional, Laske, Christoph, additional, Jessen, Frank, additional, and Düzel, Emrah, additional

Published
2018
Full Text
View/download PDF

36. Prefrontal cortical thickness in motor neuron disease

Author

Machts, Judith, primary, Cardenas-Blanco, Arturo, additional, Acosta-Cabronero, Julio, additional, Kaufmann, Joern, additional, Loewe, Kristian, additional, Kasper, Elisabeth, additional, Schuster, Christina, additional, Prudlo, Johannes, additional, Vielhaber, Stefan, additional, and Nestor, Peter J., additional

Published
2018
Full Text
View/download PDF

37. The pattern of amyloid accumulation in the brains of adults with Down syndrome

Author

Annus, Tiina, Wilson, Liam R., Hong, Young T., Acosta–Cabronero, Julio, Fryer, Tim D., Cardenas–Blanco, Arturo, Smith, Robert, Boros, Istvan, Coles, Jonathan P., Aigbirhio, Franklin I., Menon, David K., Zaman, Shahid H., Nestor, Peter J., Holland, Anthony J., Coles, Jonathan [0000-0003-4013-679X], Aigbirhio, Franklin [0000-0001-9453-5257], Menon, David [0000-0002-3228-9692], Zaman, Shahid [0000-0003-1639-6014], Holland, Anthony [0000-0003-4107-130X], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Amyloid, Epidemiology, epidemiology [Alzheimer Disease], Down syndrome, Clinical Neurology, metabolism [Amyloid beta-Peptides], Striatum, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, Humans, ddc:610, pathology [Down Syndrome], metabolism [Amyloid], Cerebral Cortex, Amyloid beta-Peptides, PIB, Health Policy, metabolism [Cerebral Cortex], methods [Positron-Emission Tomography], Age Factors, Featured Article, Alzheimer's disease, Middle Aged, Preclinical, Psychiatry and Mental health, PET, Positron-Emission Tomography, Dementia, Female, Geriatrics and Gerontology, Radiopharmaceuticals
Abstract

INTRODUCTION: Adults with Down syndrome (DS) invariably develop Alzheimer's disease (AD) neuropathology. Understanding amyloid deposition in DS can yield crucial information about disease pathogenesis. METHODS: Forty-nine adults with DS aged 25-65 underwent positron emission tomography with Pittsburgh compound-B (PIB). Regional PIB binding was assessed with respect to age, clinical, and cognitive status. RESULTS: Abnormal PIB binding became evident from 39 years, first in striatum followed by rostral prefrontal-cingulo-parietal regions, then caudal frontal, rostral temporal, primary sensorimotor and occipital, and finally parahippocampal cortex, thalamus, and amygdala. PIB binding was related to age, diagnostic status, and cognitive function. DISCUSSION: PIB binding in DS, first appearing in striatum, began around age 40 and was strongly associated with dementia and cognitive decline. The absence of a substantial time lag between amyloid accumulation and cognitive decline contrasts to sporadic/familial AD and suggests this population's suitability for an amyloid primary prevention trial.

Published
2016
Full Text
View/download PDF

38. [P2-074]: MODELING OF HIDDEN CAUSES FOR DYNAMIC CHANGES IN STRUCTURAL INTEGRITY AND COGNITION IN SUBJECTIVE COGNITIVE DECLINE: A DELCODE PROJECT

Author

Ziegler, Gabriel, primary, Penny, Will D., additional, Berron, David, additional, Cardenas-Blanco, Arturo, additional, Betts, Matthew J., additional, Schütze, Hartmut, additional, Heneka, Michael, additional, Fliessbach, Klaus, additional, Teipel, Stefan J., additional, Wagner, Michael, additional, Spottke, Annika, additional, Nestor, Peter, additional, Buerger, Katharina, additional, Schneider, Anja, additional, Peters, Oliver, additional, Priller, Josef, additional, Wiltfang, Jens, additional, Laske, Christoph, additional, Jessen, Frank, additional, and Duzel, Emrah, additional

Published
2017
Full Text
View/download PDF

40. OBJECT AND SCENE MEMORY ARE DIFFERENTIALLY ASSOCIATED WITH CSF MARKERS OF ALZHEIMER’S DISEASE AND MRI VOLUMETRY

Author

Berron, David, primary, Schütze, Hartmut, additional, Cardenas-Blanco, Arturo, additional, Fliessbach, Klaus, additional, Wagner, Michael, additional, Spottke, Annika, additional, Reuter, Martin, additional, Teipel, Stefan J., additional, Buerger, Katharina, additional, Schneider, Anja, additional, Peters, Oliver, additional, Nestor, Peter, additional, Priller, Josef, additional, Wiltfang, Jens, additional, Laske, Christoph, additional, Jessen, Frank, additional, and Düzel, Emrah, additional

Published
2017
Full Text
View/download PDF

41. Strong evidence for pattern separation in human dentate gyrus

Author

Berron, David, Schütze, Hartmut, Maass, Anne, Cardenas-Blanco, Arturo, Kuijf, Hugo J., Kumaran, Dharshan, Düzel, Emrah, Berron, David, Schütze, Hartmut, Maass, Anne, Cardenas-Blanco, Arturo, Kuijf, Hugo J., Kumaran, Dharshan, and Düzel, Emrah

Published
2016

42. Strong evidence for pattern separation in human dentate gyrus

Author

Beeldverwerking ISI, Brain, Berron, David, Schütze, Hartmut, Maass, Anne, Cardenas-Blanco, Arturo, Kuijf, Hugo J., Kumaran, Dharshan, Düzel, Emrah, Beeldverwerking ISI, Brain, Berron, David, Schütze, Hartmut, Maass, Anne, Cardenas-Blanco, Arturo, Kuijf, Hugo J., Kumaran, Dharshan, and Düzel, Emrah

Published
2016

46. Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis

Author

Cardenas-Blanco, Arturo, primary, Machts, Judith, additional, Acosta-Cabronero, Julio, additional, Kaufmann, Joern, additional, Abdulla, Susanne, additional, Kollewe, Katja, additional, Petri, Susanne, additional, Schreiber, Stefanie, additional, Heinze, Hans-Jochen, additional, Dengler, Reinhard, additional, Vielhaber, Stefan, additional, and Nestor, Peter J., additional

Published
2016
Full Text
View/download PDF

48. ASSOCIATION BETWEEN NEURAL NOVELTY RESPONSES AND CSF BIOMARKERS OF ALZHEIMER’S DISEASE: ANATOMICAL SPECIFICITY AND DEPENDENCE ON ATROPHY

Author

Düzel, Emrah, Berron, David, Cardenas-Blanco, Arturo, Metzger, Coraline D., Bittner, Daniel, Spottke, Annika, Buerger, Katharina, Fliessbach, Klaus, Heneka, Michael, Nestor, Peter, Laske, Christoph, Peters, Oliver, Priller, Josef, Schneider, Anja, Speck, Oliver, Teipel, Stefan J., Wagner, Michael, and Jessen, Frank

Published
2018
Full Text
View/download PDF

50. STRUCTURAL INTEGRITY IN SUBJECTIVE COGNITIVE DECLINE, MILD COGNITIVE IMPAIRMENT AND ALZHEIMER’S DISEASE BASED ON MULTICENTER DIFFUSION TENSOR IMAGING: RESULTS FROM THE DELCODE STUDY

Author

Brueggen, Katharina, Dyrba, Martin, Cardenas-Blanco, Arturo, Nestor, Peter, Schneider, Anja, Buerger, Katharina, Peters, Oliver, Priller, Josef, Wiltfang, Jens, Laske, Christoph, Wagner, Michael, Spottke, Annika, Düzel, Emrah, Jessen, Frank, and Teipel, Stefan J.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results