Search

Your search keyword '"Carcaboso A. M."' showing total 426 results
Start Over Author "Carcaboso A. M."
426 results on '"Carcaboso A. M."'

2. Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

Author

Thirant, Cécile, Peltier, Agathe, Durand, Simon, Kramdi, Amira, Louis-Brennetot, Caroline, Pierre-Eugène, Cécile, Gautier, Margot, Costa, Ana, Grelier, Amandine, Zaïdi, Sakina, Gruel, Nadège, Jimenez, Irène, Lapouble, Eve, Pierron, Gaëlle, Sitbon, Déborah, Brisse, Hervé J., Gauthier, Arnaud, Fréneaux, Paul, Grossetête, Sandrine, Baudrin, Laura G., Raynal, Virginie, Baulande, Sylvain, Bellini, Angela, Bhalshankar, Jaydutt, Carcaboso, Angel M., Geoerger, Birgit, Rohrer, Hermann, Surdez, Didier, Boeva, Valentina, Schleiermacher, Gudrun, Delattre, Olivier, and Janoueix-Lerosey, Isabelle

Published
2023
Full Text
View/download PDF

4. Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

Author

Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Sanford, Bridget, Birks, Diane K, Davidson, Nate, Metselaar, Dennis S, Meel, Michaël Hananja, Lemma, Rakeb, Donson, Andrew, Vijmasi, Trinka, Katagi, Hiroaki, Sola, Ismail, Fosmire, Susan, Alimova, Irina, Steiner, Jenna, Gilani, Ahmed, Hulleman, Esther, Serkova, Natalie J, Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel M, Gupta, Nalin, Monje, Michelle, Jabado, Nada, Jones, Kenneth, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, and Venkataraman, Sujatha

Subjects
Biochemistry and Cell Biology, Biological Sciences, Rare Diseases, Genetics, Stem Cell Research, Biotechnology, Cancer, Brain Disorders, Stem Cell Research - Nonembryonic - Non-Human, Brain Cancer, Aging, Astrocytoma, Brain Stem Neoplasms, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Child, Child, Preschool, Chromatin, Diffuse Intrinsic Pontine Glioma, Epigenomics, Female, Glioma, Histones, Humans, Lysine, Male, Mutation, Neoplasm Recurrence, Local, Polycomb Repressive Complex 1, BH3 mimetics, BMI1, DIPG, H3K27M mutant, H3WT, PTC 028, RNAi screen, SASP, senescence, Bmi1, PTC028, Medical Physiology, Biological sciences
Abstract

Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective treatment for this tumor. Using a combined RNAi and chemical screen targeting epigenomic regulators, we identify the polycomb repressive complex 1 (PRC1) component BMI1 as a critical factor for DIPG tumor maintenance in vivo. BMI1 chromatin occupancy is enriched at genes associated with differentiation and tumor suppressors in DIPG cells. Inhibition of BMI1 decreases cell self-renewal and attenuates tumor growth due to induction of senescence. Prolonged BMI1 inhibition induces a senescence-associated secretory phenotype, which promotes tumor recurrence. Clearance of senescent cells using BH3 protein mimetics co-operates with BMI1 inhibition to enhance tumor cell killing in vivo.

Published
2020

5. Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.

Author

Chen, Kuang-Yui, Bush, Kelly, Klein, Rachel Herndon, Cervantes, Vanessa, Lewis, Nichole, Naqvi, Aasim, Carcaboso, Angel M, Lechpammer, Mirna, and Knoepfler, Paul S

Abstract

Histone H3.3 mutations are a hallmark of pediatric gliomas, but their core oncogenic mechanisms are not well-defined. To identify major effectors, we used CRISPR-Cas9 to introduce H3.3K27M and G34R mutations into previously H3.3-wildtype brain cells, while in parallel reverting the mutations in glioma cells back to wildtype. ChIP-seq analysis broadly linked K27M to altered H3K27me3 activity including within super-enhancers, which exhibited perturbed transcriptional function. This was largely independent of H3.3 DNA binding. The K27M and G34R mutations induced several of the same pathways suggesting key shared oncogenic mechanisms including activation of neurogenesis and NOTCH pathway genes. H3.3 mutant gliomas are also particularly sensitive to NOTCH pathway gene knockdown and drug inhibition, reducing their viability in culture. Reciprocal editing of cells generally produced reciprocal effects on tumorgenicity in xenograft assays. Overall, our findings define common and distinct K27M and G34R oncogenic mechanisms, including potentially targetable pathways.

Published
2020

6. Low Bcl-2 is a robust biomarker of sensitivity to nab-paclitaxel in Ewing sarcoma

Author

Pascual-Pasto, Guillem, Resa-Pares, Claudia, Castillo-Ecija, Helena, Aschero, Rosario, Baulenas-Farres, Merce, Vila-Ubach, Monica, Burgueño, Victor, Balaguer-Lluna, Leire, Cuadrado-Vilanova, Maria, Olaciregui, Nagore G., Martinez-Velasco, Nuria, Perez-Jaume, Sara, de Alava, Enrique, Tirado, Oscar M., Lavarino, Cinzia, Mora, Jaume, and Carcaboso, Angel M.

Published
2023
Full Text
View/download PDF

7. SPARC-mediated long-term retention of nab-paclitaxel in pediatric sarcomas

Author

Pascual-Pasto, Guillem, Castillo-Ecija, Helena, Unceta, Nora, Aschero, Rosario, Resa-Pares, Claudia, Gómez-Caballero, Alberto, Vila-Ubach, Monica, Muñoz-Aznar, Oscar, Suñol, Mariona, Burgueño, Victor, Gomez-Gonzalez, Soledad, Sosnik, Alejandro, Ibarra, Manuel, Schaiquevich, Paula, de Álava, Enrique, Tirado, Oscar M., Mora, Jaume, and Carcaboso, Angel M.

Published
2022
Full Text
View/download PDF

8. PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Author

Khadka, Prasidda, Reitman, Zachary J., Lu, Sophie, Buchan, Graham, Gionet, Gabrielle, Dubois, Frank, Carvalho, Diana M., Shih, Juliann, Zhang, Shu, Greenwald, Noah F., Zack, Travis, Shapira, Ofer, Pelton, Kristine, Hartley, Rachel, Bear, Heather, Georgis, Yohanna, Jarmale, Spandana, Melanson, Randy, Bonanno, Kevin, Schoolcraft, Kathleen, Miller, Peter G., Condurat, Alexandra L., Gonzalez, Elizabeth M., Qian, Kenin, Morin, Eric, Langhnoja, Jaldeep, Lupien, Leslie E., Rendo, Veronica, Digiacomo, Jeromy, Wang, Dayle, Zhou, Kevin, Kumbhani, Rushil, Guerra Garcia, Maria E., Sinai, Claire E., Becker, Sarah, Schneider, Rachel, Vogelzang, Jayne, Krug, Karsten, Goodale, Amy, Abid, Tanaz, Kalani, Zohra, Piccioni, Federica, Beroukhim, Rameen, Persky, Nicole S., Root, David E., Carcaboso, Angel M., Ebert, Benjamin L., Fuller, Christine, Babur, Ozgun, Kieran, Mark W., Jones, Chris, Keshishian, Hasmik, Ligon, Keith L., Carr, Steven A., Phoenix, Timothy N., and Bandopadhayay, Pratiti

Published
2022
Full Text
View/download PDF

9. MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

Author

Garcia-Gerique, Laura, García, Marta, Garrido-Garcia, Alícia, Gómez-González, Soledad, Torrebadell, Montserrat, Prada, Estela, Pascual-Pasto, Guillem, Muñoz, Oscar, Perez-Jaume, Sara, Lemos, Isadora, Salvador, Noelia, Vila-Ubach, Monica, Doncel-Requena, Ana, Suñol, Mariona, Carcaboso, Angel M., Mora, Jaume, and Lavarino, Cinzia

Published
2022
Full Text
View/download PDF

10. Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T-cells

Author

Pascual-Pasto, Guillem, primary, McIntyre, Brendan, additional, Giudice, Anna M., additional, Alikarami, Fatemeh, additional, Morrissey, Amanda, additional, Matlaga, Stephanie, additional, Hofmann, Ted J., additional, Burgueño, Victor, additional, Harvey, Kyra, additional, Martinez, Daniel, additional, Shah, Amish C., additional, Foster, Jessica B., additional, Pogoriler, Jennifer, additional, Eagle, Ralph C., additional, Carcaboso, Angel M., additional, Shields, Carol L., additional, Leahey, Ann-Marie, additional, and Bosse, Kristopher R., additional

Published
2024
Full Text
View/download PDF

12. Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy

Author

Chheda, Zinal S, Kohanbash, Gary, Okada, Kaori, Jahan, Naznin, Sidney, John, Pecoraro, Matteo, Yang, Xinbo, Carrera, Diego A, Downey, Kira M, Shrivastav, Shruti, Liu, Shuming, Lin, Yi, Lagisetti, Chetana, Chuntova, Pavlina, Watchmaker, Payal B, Mueller, Sabine, Pollack, Ian F, Rajalingam, Raja, Carcaboso, Angel M, Mann, Matthias, Sette, Alessandro, Garcia, K Christopher, Hou, Yafei, and Okada, Hideho

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Genetics, Pediatric, Neurosciences, Biotechnology, Brain Cancer, Brain Disorders, Rare Diseases, Pediatric Cancer, Cancer, 2.1 Biological and endogenous factors, Adoptive Transfer, Amino Acid Sequence, Amino Acids, Animals, Antigen Presentation, Antigens, Neoplasm, Chromatography, Liquid, Disease Models, Animal, Epitope Mapping, Female, Glioma, HLA-A Antigens, Histones, Humans, Immunotherapy, Adoptive, Mice, Mice, Transgenic, Mutation, Peptides, Protein Binding, Receptors, Antigen, T-Cell, T-Cell Antigen Receptor Specificity, T-Lymphocytes, Tandem Mass Spectrometry, Xenograft Model Antitumor Assays, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

The median overall survival for children with diffuse intrinsic pontine glioma (DIPG) is less than one year. The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M) at position 27 of histone 3 variant 3 (H3.3). From a CD8+ T cell clone established by stimulation of HLA-A2+ CD8+ T cells with synthetic peptide encompassing the H3.3K27M mutation, complementary DNA for T cell receptor (TCR) α- and β-chains were cloned into a retroviral vector. TCR-transduced HLA-A2+ T cells efficiently killed HLA-A2+H3.3K27M+ glioma cells in an antigen- and HLA-specific manner. Adoptive transfer of TCR-transduced T cells significantly suppressed the progression of glioma xenografts in mice. Alanine-scanning assays suggested the absence of known human proteins sharing the key amino acid residues required for recognition by the TCR, suggesting that the TCR could be safely used in patients. These data provide us with a strong basis for developing T cell-based therapy targeting this shared neoepitope.

Published
2018

13. Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

Author

García-Domínguez, Daniel J., Hajji, Nabil, Sánchez-Molina, Sara, Figuerola-Bou, Elisabet, de Pablos, Rocío M., Espinosa-Oliva, Ana M., Andrés-León, Eduardo, Terrón-Camero, Laura Carmen, Flores-Campos, Rocío, Pascual-Pasto, Guillem, Robles, María José, Machado, Isidro, Llombart-Bosch, Antonio, Magagnoli, Giovanna, Scotlandi, Katia, Carcaboso, Ángel M., Mora, Jaume, de Álava, Enrique, and Hontecillas-Prieto, Lourdes

Published
2021
Full Text
View/download PDF

14. Treatment-driven selection of chemoresistant Ewing sarcoma tumors with limited drug distribution

Author

Castillo-Ecija, Helena, Monterrubio, Carles, Pascual-Pasto, Guillem, Gomez-Gonzalez, Soledad, Garcia-Dominguez, Daniel J., Hontecillas-Prieto, Lourdes, Resa-Pares, Claudia, Burgueño, Victor, Paco, Sonia, Olaciregui, Nagore G., Vila-Ubach, Monica, Restrepo-Perdomo, Camilo, Cuadrado-Vilanova, Maria, Balaguer-Lluna, Leire, Perez-Jaume, Sara, Castañeda, Alicia, Santa-Maria, Vicente, Roldan, Monica, Suñol, Mariona, de Alava, Enrique, Mora, Jaume, Lavarino, Cinzia, and Carcaboso, Angel M.

Published
2020
Full Text
View/download PDF

15. LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma

Author

Keskin, Tugba, Bakaric, Arnaud, Waszyk, Patricia, Boulay, Gaylor, Torsello, Matteo, Cornaz-Buros, Sandrine, Chevalier, Nadja, Geiser, Thibaud, Martin, Patricia, Volorio, Angela, Iyer, Sowmya, Kulkarni, Anupriya, Letovanec, Igor, Cherix, Stéphane, Cote, Gregory M., Choy, Edwin, Digklia, Antonia, Montemurro, Michael, Chebib, Ivan, Nielsen, Petur G., Carcaboso, Angel M., Mora, Jaume, Renella, Raffaele, Suvà, Mario L., Fusco, Carlo, Provero, Paolo, Rivera, Miguel N., Riggi, Nicolò, and Stamenkovic, Ivan

Published
2020
Full Text
View/download PDF

16. A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

Author

Liu, Jing, Ottaviani, Daniela, Sefta, Meriem, Desbrousses, Céline, Chapeaublanc, Elodie, Aschero, Rosario, Sirab, Nanor, Lubieniecki, Fabiana, Lamas, Gabriela, Tonon, Laurie, Dehainault, Catherine, Hua, Clément, Fréneaux, Paul, Reichman, Sacha, Karboul, Narjesse, Biton, Anne, Mirabal-Ortega, Liliana, Larcher, Magalie, Brulard, Céline, Arrufat, Sandrine, Nicolas, André, Elarouci, Nabila, Popova, Tatiana, Némati, Fariba, Decaudin, Didier, Gentien, David, Baulande, Sylvain, Mariani, Odette, Dufour, Florent, Guibert, Sylvain, Vallot, Céline, Rouic, Livia Lumbroso-Le, Matet, Alexandre, Desjardins, Laurence, Pascual-Pasto, Guillem, Suñol, Mariona, Catala-Mora, Jaume, Llano, Genoveva Correa, Couturier, Jérôme, Barillot, Emmanuel, Schaiquevich, Paula, Gauthier-Villars, Marion, Stoppa-Lyonnet, Dominique, Golmard, Lisa, Houdayer, Claude, Brisse, Hervé, Bernard-Pierrot, Isabelle, Letouzé, Eric, Viari, Alain, Saule, Simon, Sastre-Garau, Xavier, Doz, François, Carcaboso, Angel M., Cassoux, Nathalie, Pouponnot, Celio, Goureau, Olivier, Chantada, Guillermo, de Reyniès, Aurélien, Aerts, Isabelle, and Radvanyi, François

Published
2021
Full Text
View/download PDF

17. Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

Author

Filbin, Mariella G., Tirosh, Itay, Hovestadt, Volker, Shaw, McKenzie L., Escalante, Leah E., Mathewson, Nathan D., Neftel, Cyril, Frank, Nelli, Pelton, Kristine, Hebert, Christine M., Haberler, Christine, Yizhak, Keren, Gojo, Johannes, Egervari, Kristof, Mount, Christopher, van Galen, Peter, Bonal, Dennis M., Nguyen, Quang-De, Beck, Alexander, Sinai, Claire, Czech, Thomas, Dorfer, Christian, Goumnerova, Liliana, Lavarino, Cinzia, Carcaboso, Angel M., Mora, Jaume, Mylvaganam, Ravindra, Luo, Christina C., Peyr, Andreas, Popović, Mara, Azizi, Amedeo, Batchelor, Tracy. T., Frosch, Matthew P., Martinez-Lage, Maria, Kieran, Mark W., Bandopadhayay, Pratiti, Beroukhim, Rameen, Fritsch, Gerhard, Getz, Gad, Rozenblatt-Rosen, Orit, Wucherpfennig, Kai W., Louis, David N., Monje, Michelle, Slavc, Irene, Ligon, Keith L., Golub, Todd R., Regev, Aviv, Bernstein, Bradley E., and Suvà, Mario L.

Published
2018

20. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

Author

Janin, Maxime, Ortiz-Barahona, Vanessa, de Moura, Manuel Castro, Martínez-Cardús, Anna, Llinàs-Arias, Pere, Soler, Marta, Nachmani, Daphna, Pelletier, Joffrey, Schumann, Ulrike, Calleja-Cervantes, Maria E., Moran, Sebastian, Guil, Sonia, Bueno-Costa, Alberto, Piñeyro, David, Perez-Salvia, Montserrat, Rosselló-Tortella, Margalida, Piqué, Laia, Bech-Serra, Joan J., De La Torre, Carolina, Vidal, August, Martínez-Iniesta, María, Martín-Tejera, Juan F., Villanueva, Alberto, Arias, Alexandra, Cuartas, Isabel, Aransay, Ana M., La Madrid, Andres Morales, Carcaboso, Angel M., Santa-Maria, Vicente, Mora, Jaume, Fernandez, Agustin F., Fraga, Mario F., Aldecoa, Iban, Pedrosa, Leire, Graus, Francesc, Vidal, Noemi, Martínez-Soler, Fina, Tortosa, Avelina, Carrato, Cristina, Balañá, Carme, Boudreau, Matthew W., Hergenrother, Paul J., Kötter, Peter, Entian, Karl-Dieter, Hench, Jürgen, Frank, Stephan, Mansouri, Sheila, Zadeh, Gelareh, Dans, Pablo D., Orozco, Modesto, Thomas, George, Blanco, Sandra, Seoane, Joan, Preiss, Thomas, Pandolfi, Pier Paolo, and Esteller, Manel

Published
2019
Full Text
View/download PDF

23. Immunohistochemical expression of TFF1 is a marker of poor prognosis in retinoblastoma

Author

Aschero, Rosario, primary, Ganiewich, Daiana, additional, Lamas, Gabriela, additional, Restrepo‐Perdomo, Camilo A, additional, Ottaviani, Daniela, additional, Zugbi, Santiago, additional, Camarero, Sandra, additional, Néspoli, Ezequiel, additional, Vilanova, Maria Cuadrado, additional, Perez‐Jaume, Sara, additional, Pascual‐Pasto, Guillem, additional, Sampor, Claudia, additional, Grigorovski, Nathalia, additional, Salas, Beatriz, additional, Suñol, Mariona, additional, Carcaboso, Angel M., additional, Mora, Jaume, additional, de Dávila, María T G, additional, Doz, François, additional, Radvanyi, François, additional, Abramson, David H, additional, Llera, Andrea S, additional, Schaiquevich, Paula S, additional, Lubieniecki, Fabiana, additional, and Chantada, Guillermo L, additional

Published
2023
Full Text
View/download PDF

26. Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8

Author

Monterrubio, Carles, Paco, Sonia, Olaciregui, Nagore G., Pascual-Pasto, Guillem, Vila-Ubach, Monica, Cuadrado-Vilanova, Maria, Ferrandiz, M. Mar, Castillo-Ecija, Helena, Glisoni, Romina, Kuplennik, Nataliya, Jungbluth, Achim, de Torres, Carmen, Lavarino, Cinzia, Cheung, N.K.V., Mora, Jaume, Sosnik, Alejandro, and Carcaboso, Angel M.

Published
2017
Full Text
View/download PDF

31. Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

Author

Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R., Pemberton, Helen N., Lord, Christopher J., Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V., Qin, Elizabeth Y., Ingram, Wendy J., Moore, Andrew S., Ng, Ho-Keung, Trabelsi, Saoussen, H’mida-Ben Brahim, Dorra, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M., Monje, Michelle, Mackay, Alan, and Jones, Chris

Published
2018
Full Text
View/download PDF

32. Immunohistochemical expression of TFF1 is a new prognostic marker in retinoblastoma

Author

Aschero, Rosario, primary, Ganiewich, Daiana, additional, Lamas, Gabriela, additional, Restrepo-Perdomo, Camilo A, additional, Ottaviani, Daniela, additional, Zugbi, Santiago, additional, Camarero, Sandra, additional, Néspoli, Ezequiel, additional, Vilanova, Maria Cuadrado, additional, Perez-Jaume, Sara, additional, Pascual-Pasto, Guillem, additional, Sampor, Claudia, additional, Grigorovski, Nathalia, additional, Salas, Beatriz, additional, Suñol, Mariona, additional, Carcaboso, Angel M., additional, Mora, Jaume, additional, de Dávila, María T G, additional, Doz, François, additional, Radvanyi, François, additional, Abramson, David H, additional, Llera, Andrea S, additional, Schaiquevich, Paula S, additional, Lubieniecki, Fabiana, additional, and Chantada, Guillermo L, additional

Published
2023
Full Text
View/download PDF

34. DIPG-19. BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA

Author

Panditharatna, Eshini, primary, Marques, Joana G, additional, Wang, Tingjian, additional, Trissal, Maria, additional, Liu, Ilon, additional, Jiang, Li, additional, Beck, Alexander, additional, Groves, Andrew, additional, Dharia, Neekesh, additional, Hoffman, Samantha, additional, Kugener, Guillaume, additional, Shaw, McKenzie, additional, Hack, Olivia, additional, Dempster, Joshua, additional, Lareau, Caleb, additional, Quezada, Michael, additional, Stanton, Ann-Catherine, additional, Wyatt, Meghan, additional, Kalani, Zohra, additional, Goodale, Amy, additional, Vazquez, Francisca, additional, Piccioni, Federica, additional, Doench, John, additional, Root, David, additional, Anastas, Jamie, additional, Jones, Kristen, additional, Conway, Amy, additional, Stopka, Sylwia, additional, Regan, Michael, additional, Liang, Yu, additional, Seo, Hyuk-Soo, additional, Song, Kijun, additional, Bashyal, Puspalata, additional, Mathewson, Nathan, additional, Dhe-Paganon, Sirano, additional, Suvà, Mario L, additional, Carcaboso, Angel M, additional, Lavarino, Cinzia, additional, Mora, Jaume, additional, Nguyen, Quang-De, additional, Ligon, Keith L, additional, Shi, Yang, additional, Agnihotri, Sameer, additional, Agar, Nathalie Y R, additional, Stegmaier, Kimberly, additional, Stiles, Charles D, additional, Monje, Michelle, additional, Golub, Todd R, additional, Qi, Jun, additional, and Filbin, Mariella G, additional

Published
2023
Full Text
View/download PDF

35. Preclinical platform of retinoblastoma xenografts recapitulating human disease and molecular markers of dissemination

Author

Pascual-Pasto, Guillem, Olaciregui, Nagore G., Vila-Ubach, Monica, Paco, Sonia, Monterrubio, Carles, Rodriguez, Eva, Winter, Ursula, Batalla-Vilacis, Mireia, Catala, Jaume, Salvador, Hector, Parareda, Andreu, Schaiquevich, Paula, Suñol, Mariona, Mora, Jaume, Lavarino, Cinzia, de Torres, Carmen, Chantada, Guillermo L., and Carcaboso, Angel M.

Published
2016
Full Text
View/download PDF

38. ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma

Author

Norwegian Research Council, Southern and Eastern Norway Regional Health Authority, Nova Southeastern University, Swedish Society for Medical Research, Fundación la Caixa, European Commission, Instituto de Salud Carlos III, European Institute of Innovation and Technology, Josep Carreras Leukemia Foundation, Centres de Recerca de Catalunya, Generalitat de Catalunya, Mensali, Nadia, Köksal, Hakan, Joaquina, Sandy, Wernhoff, Patrik, Casey, Nicholas P., Romecin, Paola, Panisello, Carla, Rodriguez, René, Vimeux, Lene, Juzeniene, Asta, Myhre, Marit R., Fåne, Anne, Castilla, Carolina, Maggadottir, Solrun Melkorka, Duru, Adil Doganay, Georgoudaki, Anna-Maria, Grad, Iwona, Maturana, Andrés Daniel, Gaudernack, Gustav, Kvalheim, Gunnar, Carcaboso, Ángel M., Álava, Enrique de, Donnadieu, Emmanuel, Bruland, Øyvind S., Menéndez, Pablo, Inderberg, Else Marit, Wälchli, Sébastien, Norwegian Research Council, Southern and Eastern Norway Regional Health Authority, Nova Southeastern University, Swedish Society for Medical Research, Fundación la Caixa, European Commission, Instituto de Salud Carlos III, European Institute of Innovation and Technology, Josep Carreras Leukemia Foundation, Centres de Recerca de Catalunya, Generalitat de Catalunya, Mensali, Nadia, Köksal, Hakan, Joaquina, Sandy, Wernhoff, Patrik, Casey, Nicholas P., Romecin, Paola, Panisello, Carla, Rodriguez, René, Vimeux, Lene, Juzeniene, Asta, Myhre, Marit R., Fåne, Anne, Castilla, Carolina, Maggadottir, Solrun Melkorka, Duru, Adil Doganay, Georgoudaki, Anna-Maria, Grad, Iwona, Maturana, Andrés Daniel, Gaudernack, Gustav, Kvalheim, Gunnar, Carcaboso, Ángel M., Álava, Enrique de, Donnadieu, Emmanuel, Bruland, Øyvind S., Menéndez, Pablo, Inderberg, Else Marit, and Wälchli, Sébastien

Abstract

Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. Here we show that chimeric antigen receptor (CAR) T cells could successfully target an isoform of alkaline phosphatase, ALPL-1, which is highly and specifically expressed in primary and metastatic OS. The target recognition element of the second-generation CAR construct is based on two antibodies, previously shown to react against OS. T cells transduced with these CAR constructs mediate efficient and effective cytotoxicity against ALPL-positive cells in in vitro settings and in state-of-the-art in vivo orthotopic models of primary and metastatic OS, without unexpected toxicities against hematopoietic stem cells or healthy tissues. In summary, CAR-T cells targeting ALPL-1 show efficiency and specificity in treating OS in preclinical models, paving the path for clinical translation.

Published
2023

39. Supplementary information. ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma

Author

Mensali, Nadia, Köksal, Hakan, Joaquina, Sandy, Wernhoff, Patrik, Casey, Nicholas P., Romecin, Paola, Panisello, Carla, Rodriguez, René, Vimeux, Lene, Juzeniene, Asta, Myhre, Marit R., Fåne, Anne, Castilla, Carolina, Maggadottir, Solrun Melkorka, Duru, Adil Doganay, Georgoudaki, Anna-Maria, Grad, Iwona, Maturana, Andrés Daniel, Gaudernack, Gustav, Kvalheim, Gunnar, Carcaboso, Ángel M., Álava, Enrique de, Donnadieu, Emmanuel, Bruland, Øyvind S., Menéndez, Pablo, Inderberg, Else Marit, Wälchli, Sébastien, Mensali, Nadia, Köksal, Hakan, Joaquina, Sandy, Wernhoff, Patrik, Casey, Nicholas P., Romecin, Paola, Panisello, Carla, Rodriguez, René, Vimeux, Lene, Juzeniene, Asta, Myhre, Marit R., Fåne, Anne, Castilla, Carolina, Maggadottir, Solrun Melkorka, Duru, Adil Doganay, Georgoudaki, Anna-Maria, Grad, Iwona, Maturana, Andrés Daniel, Gaudernack, Gustav, Kvalheim, Gunnar, Carcaboso, Ángel M., Álava, Enrique de, Donnadieu, Emmanuel, Bruland, Øyvind S., Menéndez, Pablo, Inderberg, Else Marit, and Wälchli, Sébastien

Published
2023

40. Low Bcl-2 is a robust biomarker of sensitivity to nab-paclitaxel in Ewing sarcoma

Author

Fundación Científica Asociación Española Contra el Cáncer, European Commission, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Pascual-Pasto, Guillem, Resa-Pares, Claudia, Castillo-Écija, Helena, Aschero, Rosario, Baulenas-Farres, Merce, Vila-Ubach, Mónica, Burgueño, Víctor, Balaguer-Lluna, Leire, Cuadrado-Vilanova, María, Olaciregui, Nagore G., Martinez-Velasco, Nuria, Pérez-Jaume, Sara, Álava, Enrique de, Tirado, Óscar M., Lavarino, Cinzia, Mora, Jaume, Carcaboso, Ángel M., Fundación Científica Asociación Española Contra el Cáncer, European Commission, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Pascual-Pasto, Guillem, Resa-Pares, Claudia, Castillo-Écija, Helena, Aschero, Rosario, Baulenas-Farres, Merce, Vila-Ubach, Mónica, Burgueño, Víctor, Balaguer-Lluna, Leire, Cuadrado-Vilanova, María, Olaciregui, Nagore G., Martinez-Velasco, Nuria, Pérez-Jaume, Sara, Álava, Enrique de, Tirado, Óscar M., Lavarino, Cinzia, Mora, Jaume, and Carcaboso, Ángel M.

Abstract

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) shows potent preclinical anticancer activity in pediatric solid tumors such as Ewing sarcoma, rhabdomyosarcoma and neuroblastoma, but responses in clinical trials have been modest. In this work, we aimed to discover a rational biomarker-based approach to select the right candidate patients for this treatment. We assessed the efficacy of nab-paclitaxel in 27 patient-derived xenografts (PDX), including 14 Ewing sarcomas, five rhabdomyosarcomas and several other pediatric solid tumors. Response rate (partial or complete response) was remarkable in rhabdomyosarcomas (four of five) and Ewing sarcomas (four of 14). We addressed several predictive factors of response to nab-paclitaxel such as the expression of the secreted protein acidic and rich in cysteine (SPARC), chromosomal stability of cancer cells and expression of antiapoptotic members of the B-cell lymphoma-2 (Bcl-2) family of proteins such as Bcl-2, Bcl-xL, Bcl-W and Mcl-1. Protein (immunoblotting) and gene expression of SPARC correlated positively, while immunoblotting and immunohistochemistry expression of Bcl-2 correlated negatively with the efficacy of nab-paclitaxel in Ewing sarcoma PDX. The negative correlation of Bcl-2 immunoblotting signal and activity was especially robust (r = 0.8352; P = 0.0007; Pearson correlation). Consequently, we evaluated pharmacological strategies to inhibit Bcl-2 during nab-paclitaxel treatment. We observed that the Bcl-2 inhibitor venetoclax improved the activity of nab-paclitaxel in highly resistant Bcl-2-expressing Ewing sarcoma PDX. Overall, our results suggest that low Bcl-2 expression could be used to select patients with Ewing sarcoma sensitive to nab-paclitaxel, and Bcl-2 inhibitors could improve the activity of this drug in Bcl-2-expressing Ewing sarcoma.

Published
2023

41. Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

Author

Thirant, Cécile; https://orcid.org/0000-0003-3873-5240, Peltier, Agathe; https://orcid.org/0000-0003-0017-277X, Durand, Simon; https://orcid.org/0000-0003-1748-7655, Kramdi, Amira, Louis-Brennetot, Caroline; https://orcid.org/0000-0002-4952-3828, Pierre-Eugène, Cécile, Gautier, Margot; https://orcid.org/0000-0003-4028-3466, Costa, Ana; https://orcid.org/0000-0002-0893-3388, Grelier, Amandine, Zaïdi, Sakina; https://orcid.org/0000-0001-9128-0287, Gruel, Nadège, Jimenez, Irène; https://orcid.org/0000-0002-3544-4045, Lapouble, Eve; https://orcid.org/0000-0003-3374-3671, Pierron, Gaëlle; https://orcid.org/0000-0002-2536-7680, Sitbon, Déborah, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Gauthier, Arnaud, Fréneaux, Paul, Grossetête, Sandrine, Baudrin, Laura G, Raynal, Virginie, Baulande, Sylvain, Bellini, Angela, Bhalshankar, Jaydutt, Carcaboso, Angel M; https://orcid.org/0000-0002-8485-426X, Geoerger, Birgit; https://orcid.org/0000-0003-4361-3643, Rohrer, Hermann; https://orcid.org/0000-0001-7023-1355, Surdez, Didier; https://orcid.org/0000-0002-7118-7859, Boeva, Valentina; https://orcid.org/0000-0002-4382-7185, Schleiermacher, Gudrun; https://orcid.org/0000-0002-0133-5879, et al, Thirant, Cécile; https://orcid.org/0000-0003-3873-5240, Peltier, Agathe; https://orcid.org/0000-0003-0017-277X, Durand, Simon; https://orcid.org/0000-0003-1748-7655, Kramdi, Amira, Louis-Brennetot, Caroline; https://orcid.org/0000-0002-4952-3828, Pierre-Eugène, Cécile, Gautier, Margot; https://orcid.org/0000-0003-4028-3466, Costa, Ana; https://orcid.org/0000-0002-0893-3388, Grelier, Amandine, Zaïdi, Sakina; https://orcid.org/0000-0001-9128-0287, Gruel, Nadège, Jimenez, Irène; https://orcid.org/0000-0002-3544-4045, Lapouble, Eve; https://orcid.org/0000-0003-3374-3671, Pierron, Gaëlle; https://orcid.org/0000-0002-2536-7680, Sitbon, Déborah, Brisse, Hervé J; https://orcid.org/0000-0003-2794-5875, Gauthier, Arnaud, Fréneaux, Paul, Grossetête, Sandrine, Baudrin, Laura G, Raynal, Virginie, Baulande, Sylvain, Bellini, Angela, Bhalshankar, Jaydutt, Carcaboso, Angel M; https://orcid.org/0000-0002-8485-426X, Geoerger, Birgit; https://orcid.org/0000-0003-4361-3643, Rohrer, Hermann; https://orcid.org/0000-0001-7023-1355, Surdez, Didier; https://orcid.org/0000-0002-7118-7859, Boeva, Valentina; https://orcid.org/0000-0002-4382-7185, Schleiermacher, Gudrun; https://orcid.org/0000-0002-0133-5879, and et al

Abstract

Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries. However, their relationship and relative contribution in patient tumors remain poorly defined. We now document spontaneous and reversible plasticity between the two identities, associated with epigenetic reprogramming, in several neuroblastoma models. Interestingly, xenografts with cells from each identity eventually harbor a noradrenergic phenotype suggesting that the microenvironment provides a powerful pressure towards this phenotype. Accordingly, such a noradrenergic cell identity is systematically observed in single-cell RNA-seq of 18 tumor biopsies and 15 PDX models. Yet, a subpopulation of these noradrenergic tumor cells presents with mesenchymal features that are shared with plasticity models, indicating that the plasticity described in these models has relevance in neuroblastoma patients. This work therefore emphasizes that intrinsic plasticity properties of neuroblastoma cells are dependent upon external cues of the environment to drive cell identity.

Published
2023

42. Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models

Author

Tucker, Elizabeth R; https://orcid.org/0000-0003-3716-6605, Jiménez, Irene; https://orcid.org/0000-0002-3544-4045, Chen, Lindi; https://orcid.org/0000-0001-7223-4226, Bellini, Angela; https://orcid.org/0000-0001-7374-1887, Gorrini, Chiara; https://orcid.org/0000-0002-5239-6671, Calton, Elizabeth; https://orcid.org/0000-0002-3662-8401, Gao, Qiong; https://orcid.org/0000-0002-0406-1594, Che, Harvey; https://orcid.org/0000-0003-1011-4653, Poon, Evon; https://orcid.org/0000-0002-0616-2487, Jamin, Yann; https://orcid.org/0000-0003-0350-3757, Da Costa, Barbara Martins; https://orcid.org/0000-0002-8993-6790, Barker, Karen; https://orcid.org/0000-0002-2357-3894, Shrestha, Sumana; https://orcid.org/0000-0002-5368-0818, Hutchinson, J Ciaran; https://orcid.org/0000-0002-1708-2634, Dhariwal, Simran; https://orcid.org/0000-0003-2386-9748, Goodman, Angharad; https://orcid.org/0000-0002-3010-5757, Del Nery, Elaine; https://orcid.org/0000-0002-9654-5202, Gestraud, Pierre; https://orcid.org/0000-0002-3893-9879, Bhalshankar, Jaydutt; https://orcid.org/0000-0001-7184-943X, Iddir, Yasmine; https://orcid.org/0000-0002-7022-0725, Saberi-Ansari, Elnaz; https://orcid.org/0000-0003-2472-1075, Saint-Charles, Alexandra; https://orcid.org/0000-0001-7779-7669, Geoerger, Birgit; https://orcid.org/0000-0003-4361-3643, Da Costa, Maria Eugénia Marques; https://orcid.org/0000-0002-1498-603X, Pierre-Eugène, Cécile; https://orcid.org/0000-0002-0351-7211, Janoueix-Lerosey, Isabelle; https://orcid.org/0000-0003-0434-3003, Decaudin, Didier; https://orcid.org/0000-0003-2254-0043, Nemati, Fariba; https://orcid.org/0000-0001-8879-7592, Carcaboso, Angel M; https://orcid.org/0000-0002-8485-426X, Surdez, Didier; https://orcid.org/0000-0002-7118-7859, et al, Tucker, Elizabeth R; https://orcid.org/0000-0003-3716-6605, Jiménez, Irene; https://orcid.org/0000-0002-3544-4045, Chen, Lindi; https://orcid.org/0000-0001-7223-4226, Bellini, Angela; https://orcid.org/0000-0001-7374-1887, Gorrini, Chiara; https://orcid.org/0000-0002-5239-6671, Calton, Elizabeth; https://orcid.org/0000-0002-3662-8401, Gao, Qiong; https://orcid.org/0000-0002-0406-1594, Che, Harvey; https://orcid.org/0000-0003-1011-4653, Poon, Evon; https://orcid.org/0000-0002-0616-2487, Jamin, Yann; https://orcid.org/0000-0003-0350-3757, Da Costa, Barbara Martins; https://orcid.org/0000-0002-8993-6790, Barker, Karen; https://orcid.org/0000-0002-2357-3894, Shrestha, Sumana; https://orcid.org/0000-0002-5368-0818, Hutchinson, J Ciaran; https://orcid.org/0000-0002-1708-2634, Dhariwal, Simran; https://orcid.org/0000-0003-2386-9748, Goodman, Angharad; https://orcid.org/0000-0002-3010-5757, Del Nery, Elaine; https://orcid.org/0000-0002-9654-5202, Gestraud, Pierre; https://orcid.org/0000-0002-3893-9879, Bhalshankar, Jaydutt; https://orcid.org/0000-0001-7184-943X, Iddir, Yasmine; https://orcid.org/0000-0002-7022-0725, Saberi-Ansari, Elnaz; https://orcid.org/0000-0003-2472-1075, Saint-Charles, Alexandra; https://orcid.org/0000-0001-7779-7669, Geoerger, Birgit; https://orcid.org/0000-0003-4361-3643, Da Costa, Maria Eugénia Marques; https://orcid.org/0000-0002-1498-603X, Pierre-Eugène, Cécile; https://orcid.org/0000-0002-0351-7211, Janoueix-Lerosey, Isabelle; https://orcid.org/0000-0003-0434-3003, Decaudin, Didier; https://orcid.org/0000-0003-2254-0043, Nemati, Fariba; https://orcid.org/0000-0001-8879-7592, Carcaboso, Angel M; https://orcid.org/0000-0002-8485-426X, Surdez, Didier; https://orcid.org/0000-0002-7118-7859, and et al

Abstract

PURPOSE ALK-activating mutations are identified in approximately 10% of newly diagnosed neuroblastomas and ALK amplifications in a further 1%-2% of cases. Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK) inhibitor, will soon be given alongside induction chemotherapy for children with ALK-aberrant neuroblastoma. However, resistance to single-agent treatment has been reported and therapies that improve the response duration are urgently required. We studied the preclinical combination of lorlatinib with chemotherapy, or with the MDM2 inhibitor, idasanutlin, as recent data have suggested that ALK inhibitor resistance can be overcome through activation of the p53-MDM2 pathway. EXPERIMENTAL DESIGN We compared different ALK inhibitors in preclinical models prior to evaluating lorlatinib in combination with chemotherapy or idasanutlin. We developed a triple chemotherapy (CAV: cyclophosphamide, doxorubicin, and vincristine) in vivo dosing schedule and applied this to both neuroblastoma genetically engineered mouse models (GEMM) and patient-derived xenografts (PDX). RESULTS Lorlatinib in combination with chemotherapy was synergistic in immunocompetent neuroblastoma GEMM. Significant growth inhibition in response to lorlatinib was only observed in the ALK-amplified PDX model with high ALK expression. In this PDX, lorlatinib combined with idasanutlin resulted in complete tumor regression and significantly delayed tumor regrowth. CONCLUSIONS In our preclinical neuroblastoma models, high ALK expression was associated with lorlatinib response alone or in combination with either chemotherapy or idasanutlin. The synergy between MDM2 and ALK inhibition warrants further evaluation of this combination as a potential clinical approach for children with neuroblastoma.

Published
2023

43. Immunohistochemical expression of TFF1 is a marker of poor prognosis in retinoblastoma.

Author

Aschero, Rosario, Ganiewich, Daiana, Lamas, Gabriela, Restrepo-Perdomo, Camilo A., Ottaviani, Daniela, Zugbi, Santiago, Camarero, Sandra, Néspoli, Ezequiel, Vilanova, Maria Cuadrado, Perez-Jaume, Sara, Pascual-Pasto, Guillem, Sampor, Claudia, Grigorovski, Nathalia, Salas, Beatriz, Suñol, Mariona, Carcaboso, Angel M., Mora, Jaume, de Dávila, María T. G., Doz, François, and Radvanyi, François

Published
2024
Full Text
View/download PDF

44. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Author

Mack, Stephen C., Pajtler, Kristian W., Chavez, Lukas, Okonechnikov, Konstantin, Bertrand, Kelsey C., Wang, Xiuxing, Erkek, Serap, Federation, Alexander, Song, Anne, Lee, Christine, Wang, Xin, McDonald, Laura, Morrow, James J., Saiakhova, Alina, Sin-Chan, Patrick, Wu, Qiulian, Michaelraj, Kulandaimanuvel Antony, Miller, Tyler E., Hubert, Christopher G., Ryzhova, Marina, Garzia, Livia, Donovan, Laura, Dombrowski, Stephen, Factor, Daniel C., Luu, Betty, Valentim, Claudia L. L., Gimple, Ryan C., Morton, Andrew, Kim, Leo, Prager, Briana C., Lee, John J. Y., Wu, Xiaochong, Zuccaro, Jennifer, Thompson, Yuan, Holgado, Borja L., Reimand, Jri, Ke, Susan Q., Tropper, Adam, Lai, Sisi, Vijayarajah, Senthuran, Doan, Sylvia, Mahadev, Vaidehi, Mian, Ana Fernandez, Grbner, Susanne N., Lienhard, Matthias, Zapatka, Marc, Huang, Zhiqin, Aldape, Kenneth D., Carcaboso, Angel M., Houghton, Peter J., Keir, Stephen T., Milde, Till, Witt, Hendrik, Li, Yan, Li, Chao-Jun, Bian, Xiu-Wu, Jones, David T. W., Scott, Ian, Singh, Sheila K., Huang, Annie, Dirks, Peter B., Bouffet, Eric, Bradner, James E., Ramaswamy, Vijay, Jabado, Nada, Rutka, James T., Northcott, Paul A., Lupien, Mathieu, Lichter, Peter, Korshunov, Andrey, Scacheri, Peter C., Pfister, Stefan M., Kool, Marcel, Taylor, Michael D., and Rich, Jeremy N.

Subjects
Care and treatment, Physiological aspects, Genetic aspects, Research, Gliomas -- Physiological aspects -- Genetic aspects -- Care and treatment, Cancer genetics -- Research, Cancer research
Abstract

Author(s): Stephen C. Mack [1, 2, 3, 4]; Kristian W. Pajtler [5, 6, 7]; Lukas Chavez [5, 6, 8]; Konstantin Okonechnikov [5, 6]; Kelsey C. Bertrand [1, 2, 9]; Xiuxing [...]

Published
2018
Full Text
View/download PDF

45. Data from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Author

Panditharatna, Eshini, primary, Marques, Joana G., primary, Wang, Tingjian, primary, Trissal, Maria C., primary, Liu, Ilon, primary, Jiang, Li, primary, Beck, Alexander, primary, Groves, Andrew, primary, Dharia, Neekesh V., primary, Li, Deyao, primary, Hoffman, Samantha E., primary, Kugener, Guillaume, primary, Shaw, McKenzie L., primary, Mire, Hafsa M., primary, Hack, Olivia A., primary, Dempster, Joshua M., primary, Lareau, Caleb, primary, Dai, Lingling, primary, Sigua, Logan H., primary, Quezada, Michael A., primary, Stanton, Ann-Catherine J., primary, Wyatt, Meghan, primary, Kalani, Zohra, primary, Goodale, Amy, primary, Vazquez, Francisca, primary, Piccioni, Federica, primary, Doench, John G., primary, Root, David E., primary, Anastas, Jamie N., primary, Jones, Kristen L., primary, Conway, Amy Saur, primary, Stopka, Sylwia, primary, Regan, Michael S., primary, Liang, Yu, primary, Seo, Hyuk-Soo, primary, Song, Kijun, primary, Bashyal, Puspalata, primary, Jerome, William P., primary, Mathewson, Nathan D., primary, Dhe-Paganon, Sirano, primary, Suvà, Mario L., primary, Carcaboso, Angel M., primary, Lavarino, Cinzia, primary, Mora, Jaume, primary, Nguyen, Quang-De, primary, Ligon, Keith L., primary, Shi, Yang, primary, Agnihotri, Sameer, primary, Agar, Nathalie Y.R., primary, Stegmaier, Kimberly, primary, Stiles, Charles D., primary, Monje, Michelle, primary, Golub, Todd R., primary, Qi, Jun, primary, and Filbin, Mariella G., primary

Published
2023
Full Text
View/download PDF

46. Supplementary Table from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Author

Panditharatna, Eshini, primary, Marques, Joana G., primary, Wang, Tingjian, primary, Trissal, Maria C., primary, Liu, Ilon, primary, Jiang, Li, primary, Beck, Alexander, primary, Groves, Andrew, primary, Dharia, Neekesh V., primary, Li, Deyao, primary, Hoffman, Samantha E., primary, Kugener, Guillaume, primary, Shaw, McKenzie L., primary, Mire, Hafsa M., primary, Hack, Olivia A., primary, Dempster, Joshua M., primary, Lareau, Caleb, primary, Dai, Lingling, primary, Sigua, Logan H., primary, Quezada, Michael A., primary, Stanton, Ann-Catherine J., primary, Wyatt, Meghan, primary, Kalani, Zohra, primary, Goodale, Amy, primary, Vazquez, Francisca, primary, Piccioni, Federica, primary, Doench, John G., primary, Root, David E., primary, Anastas, Jamie N., primary, Jones, Kristen L., primary, Conway, Amy Saur, primary, Stopka, Sylwia, primary, Regan, Michael S., primary, Liang, Yu, primary, Seo, Hyuk-Soo, primary, Song, Kijun, primary, Bashyal, Puspalata, primary, Jerome, William P., primary, Mathewson, Nathan D., primary, Dhe-Paganon, Sirano, primary, Suvà, Mario L., primary, Carcaboso, Angel M., primary, Lavarino, Cinzia, primary, Mora, Jaume, primary, Nguyen, Quang-De, primary, Ligon, Keith L., primary, Shi, Yang, primary, Agnihotri, Sameer, primary, Agar, Nathalie Y.R., primary, Stegmaier, Kimberly, primary, Stiles, Charles D., primary, Monje, Michelle, primary, Golub, Todd R., primary, Qi, Jun, primary, and Filbin, Mariella G., primary

Published
2023
Full Text
View/download PDF

48. Supplementary Figure from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Author

Panditharatna, Eshini, primary, Marques, Joana G., primary, Wang, Tingjian, primary, Trissal, Maria C., primary, Liu, Ilon, primary, Jiang, Li, primary, Beck, Alexander, primary, Groves, Andrew, primary, Dharia, Neekesh V., primary, Li, Deyao, primary, Hoffman, Samantha E., primary, Kugener, Guillaume, primary, Shaw, McKenzie L., primary, Mire, Hafsa M., primary, Hack, Olivia A., primary, Dempster, Joshua M., primary, Lareau, Caleb, primary, Dai, Lingling, primary, Sigua, Logan H., primary, Quezada, Michael A., primary, Stanton, Ann-Catherine J., primary, Wyatt, Meghan, primary, Kalani, Zohra, primary, Goodale, Amy, primary, Vazquez, Francisca, primary, Piccioni, Federica, primary, Doench, John G., primary, Root, David E., primary, Anastas, Jamie N., primary, Jones, Kristen L., primary, Conway, Amy Saur, primary, Stopka, Sylwia, primary, Regan, Michael S., primary, Liang, Yu, primary, Seo, Hyuk-Soo, primary, Song, Kijun, primary, Bashyal, Puspalata, primary, Jerome, William P., primary, Mathewson, Nathan D., primary, Dhe-Paganon, Sirano, primary, Suvà, Mario L., primary, Carcaboso, Angel M., primary, Lavarino, Cinzia, primary, Mora, Jaume, primary, Nguyen, Quang-De, primary, Ligon, Keith L., primary, Shi, Yang, primary, Agnihotri, Sameer, primary, Agar, Nathalie Y.R., primary, Stegmaier, Kimberly, primary, Stiles, Charles D., primary, Monje, Michelle, primary, Golub, Todd R., primary, Qi, Jun, primary, and Filbin, Mariella G., primary

Published
2023
Full Text
View/download PDF

49. Data from Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models

Author

Tucker, Elizabeth R., primary, Jiménez, Irene, primary, Chen, Lindi, primary, Bellini, Angela, primary, Gorrini, Chiara, primary, Calton, Elizabeth, primary, Gao, Qiong, primary, Che, Harvey, primary, Poon, Evon, primary, Jamin, Yann, primary, Martins Da Costa, Barbara, primary, Barker, Karen, primary, Shrestha, Sumana, primary, Hutchinson, J. Ciaran, primary, Dhariwal, Simran, primary, Goodman, Angharad, primary, Del Nery, Elaine, primary, Gestraud, Pierre, primary, Bhalshankar, Jaydutt, primary, Iddir, Yasmine, primary, Saberi-Ansari, Elnaz, primary, Saint-Charles, Alexandra, primary, Geoerger, Birgit, primary, Marques Da Costa, Maria Eugénia, primary, Pierre-Eugène, Cécile, primary, Janoueix-Lerosey, Isabelle, primary, Decaudin, Didier, primary, Nemati, Fariba, primary, Carcaboso, Angel M., primary, Surdez, Didier, primary, Delattre, Olivier, primary, George, Sally L., primary, Chesler, Louis, primary, Tweddle, Deborah A., primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

50. Figure S2 from Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models

Author

Tucker, Elizabeth R., primary, Jiménez, Irene, primary, Chen, Lindi, primary, Bellini, Angela, primary, Gorrini, Chiara, primary, Calton, Elizabeth, primary, Gao, Qiong, primary, Che, Harvey, primary, Poon, Evon, primary, Jamin, Yann, primary, Martins Da Costa, Barbara, primary, Barker, Karen, primary, Shrestha, Sumana, primary, Hutchinson, J. Ciaran, primary, Dhariwal, Simran, primary, Goodman, Angharad, primary, Del Nery, Elaine, primary, Gestraud, Pierre, primary, Bhalshankar, Jaydutt, primary, Iddir, Yasmine, primary, Saberi-Ansari, Elnaz, primary, Saint-Charles, Alexandra, primary, Geoerger, Birgit, primary, Marques Da Costa, Maria Eugénia, primary, Pierre-Eugène, Cécile, primary, Janoueix-Lerosey, Isabelle, primary, Decaudin, Didier, primary, Nemati, Fariba, primary, Carcaboso, Angel M., primary, Surdez, Didier, primary, Delattre, Olivier, primary, George, Sally L., primary, Chesler, Louis, primary, Tweddle, Deborah A., primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results