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6. The role of atherectomy in the treatment of lower extremity peripheral artery disease

Author

Franzone Anna, Ferrone Marco, Carotenuto Giuseppe, Carbone Andreina, Scudiero Laura, Serino Federica, Scudiero Fernando, Izzo Raffaele, Piccolo Raffaele, Saviano Savio, Amato Bruno, Perrino Cinzia, Trimarco Bruno, and Esposito Giovanni

Subjects
Surgery, RD1-811
Abstract

Abstract Background The incidence of lower extremity peripheral artery disease (LE-PAD) continues to increase and associated morbidity remains high. Despite the significant development of percutaneous revascularization strategies, over the past decade, LE-PAD still represents a unique challenge for interventional cardiologists and vascular surgeons. Method Typical features of atherosclerosis that affects peripheral vascular bed (diffuse nature, poor distal runoff, critical limb ischemia, chronic total occlusion) contribute to the disappointing results of traditional percutaneous transluminal angioplasty (PTA). New technologies have been developed in attempt to improve the safety and effectiveness of percutaneous revascularization. Among these, atherectomy, debulking and removing atherosclerotic plaque, offers the potential advantage of eliminating stretch on arterial walls and reducing rates of restenosis. Conclusions This review summarizes the features and the current applications of new debulking devices.

Published
2012
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7. Use of statins in lower extremity artery disease: a review

Author

Gargiulo Giuseppe, Giugliano Giuseppe, Brevetti Linda, Sannino Anna, Schiattarella Gabriele Giacomo, Serino Federica, Carbone Andreina, Scudiero Fernando, Ferrone Marco, Corrado Roberto, Izzo Raffaele, Chiariotti Lorenzo, Perrino Cinzia, Amato Bruno, Trimarco Bruno, and Esposito Giovanni

Subjects
Surgery, RD1-811
Abstract

Abstract Background Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk. Description It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached. Conclusions Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.

Published
2012
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8. Endovascular treatment of lower extremity arteries is associated with an improved outcome in diabetic patients affected by intermittent claudication

Author

Giugliano Giuseppe, Perrino Cinzia, Schiano Vittorio, Brevetti Linda, Sannino Anna, Schiattarella Gabriele Giacomo, Gargiulo Giuseppe, Serino Federica, Ferrone Marco, Scudiero Fernando, Carbone Andreina, Bruno Antonio, Amato Bruno, Trimarco Bruno, and Esposito Giovanni

Subjects
Surgery, RD1-811
Abstract

Abstract Background Lower extremity peripheral arterial disease (LE-PAD) is a highly prevalent condition among diabetic patients, associated with reduced walking capacity and a high incidence of cardiovascular events. Endovascular revascularization of lower extremities arteries improves walking performance and quality of life of diabetic patients affected by intermittent claudication, but few studies evaluated the impact of revascularization on cardiovascular outcome in this high-risk population. Accordingly, in the present study we evaluated if leg-ischemia resolution by effective lower limbs percutaneous revascularization can also impact cardiovascular outcome in a homogeneous group of diabetic patients affected by intermittent claudication. Methods 236 diabetic patients affected by LE-PAD at stage II of Fontaine’s classification, with ankle/brachial index ≤0.90 and one or more hemodynamically significant stenosis in at least one artery of the ileo-femoro-popliteal axis were enrolled in the study. According to the Trans-Atlantic Inter Society Consensus II recommendations, 123 (52.1%) underwent percutaneous transluminal angioplasty (PTA group), while 113 (47.9%) underwent conservative medical therapy only (MT group). The incidence of major cardiovascular events (cardiovascular death, myocardial infarction, ischemic stroke, coronary or carotid revascularization) was prospectively analyzed with Kaplan-Meier curves and the risk of developing a cardiovascular event calculated by Cox analyses. Results No baseline difference in cardiovascular risk factors were observed between the PTA and MT groups, except for a lower prevalence of males in PTA group (74.8% vs. 85.8%, p=0.034). Furthermore, patients in the PTA group showed a worse walking capacity as expressed by maximum walking distance (108.7 ± 300.9 vs 378.4 ± 552.3 meters, p Conclusions The present study shows that lower limbs revascularization of diabetic patients affected by intermittent claudication, in addition to improve walking performance, is associated with a reduction in the incidence of future major cardiovascular events.

Published
2012
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9. Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors

Author

Giugliano Giuseppe, Laurenzano Eugenio, Rengo Carlo, De Rosa Giovanna, Brevetti Linda, Sannino Anna, Perrino Cinzia, Chiariotti Lorenzo, Schiattarella Gabriele Giacomo, Serino Federica, Ferrone Marco, Scudiero Fernando, Carbone Andreina, Sorropago Antonio, Amato Bruno, Trimarco Bruno, and Esposito Giovanni

Subjects
Surgery, RD1-811
Abstract

Abstract Background Abdominal aortic aneurysm (AAA) is a frequent cause of death among elderly. Patients affected by lower extremity peripheral arterial disease (LE-PAD) seem to be particularly at high risk for AAA. We aimed this study at assessing the prevalence and the clinical predictors of the presence of AAA in a homogeneous cohort of LE-PAD patients affected by intermittent claudication. Methods We performed an abdominal ultrasound in 213 consecutive patients with documented LE-PAD (ankle/brachial index ≤0.90) attending our outpatient clinic for intermittent claudication. For each patient we registered cardiovascular risk factors and comorbidities, and measured neutrophil count. Results The ultrasound was inconclusive in 3 patients (1.4%), thus 210 patients (169 males, 41 females, mean age 65.9 ± 9.8 yr) entered the study. Overall, AAA was present in 19 patients (9.0%), with a not significant higher prevalence in men than in women (10.1% vs 4.9%, p = 0.300). Patients with AAA were older (71.2 ± 7.0 vs 65.4 ± 9.9 years, p = 0.015), were more likely to have hypertension (94.7% vs 71.2%, p = 0.027), and greater neutrophil count (5.5 [4.5 – 6.2] vs 4.1 [3.2 – 5.5] x103/μL, p = 0.010). Importantly, the c-statistic for neutrophil count (0.73, 95% CI 0.60 – 0.86, p =0.010) was higher than that for age (0.67, CI 0.56–0.78, p = 0.017). The prevalence of AAA in claudicant patients with a neutrophil count ≥ 5.1 x103/μL (cut-off identified at ROC analysis) was as high as 29.0%. Conclusions Prevalence of AAA in claudicant patients is much higher than that reported in the general population. Ultrasound screening should be considered in these patients, especially in those with an elevated neutrophil count.

Published
2012
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15. Contributors

Author

Baggish, Aaron, primary, Bossone, Eduardo, additional, Cameli, Matteo, additional, Carbone, Andreina, additional, Castelletti, Silvia, additional, Ciriello, Giovanni Domenico, additional, Correra, Anna, additional, D’Andrea, Antonello, additional, D’Ascenzi, Flavio, additional, Dweck, Marc, additional, Gambardella, Francesco, additional, La Gerche, Andre, additional, Limongelli, Giuseppe, additional, Monda, Emanuele, additional, Palermi, Stefano, additional, Papaccioli, Giovanni, additional, Papadakis, Michael, additional, Picano, Eugenio, additional, Pontone, Gianluca, additional, Russo, Vincenzo, additional, Sarubbi, Berardo, additional, Serio, Alessandro, additional, and Sperlongano, Simona, additional

Published
2023
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18. Cardiac Risk Factors for Immunotherapy

Author

Carbone, Andreina, Quagliariello, Vincenzo, Iovine, Martina, Canale, Maria Laura, Maurea, Nicola, Giordano, Antonio, Series Editor, Russo, Antonio, editor, Maurea, Nicola, editor, and Farmakis, Dimitrios, editor

Published
2022
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21. The 'Obesity Paradox' and the Use of NOAC

Author

Bottino, Roberta, Carbone, Andreina, Liccardo, Biagio, Golino, Paolo, Nigro, Gerardo, Russo, Vincenzo, Proietti, Riccardo, editor, AlTurki, Ahmed, editor, Ferri, Nicola, editor, Russo, Vincenzo, editor, and Bunch, T. Jared, editor

Published
2021
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23. Direct Oral Anticoagulation in Cancer Patients

Author

Bottino, Roberta, Carbone, Andreina, Liccardo, Biagio, D’Andrea, Antonello, Golino, Paolo, Nigro, Gerardo, Russo, Vincenzo, Proietti, Riccardo, editor, AlTurki, Ahmed, editor, Ferri, Nicola, editor, Russo, Vincenzo, editor, and Bunch, T. Jared, editor

Published
2021
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25. Exercise Pulmonary Hypertension in Heart Valve Disease

Author

Schiavo, Alessandra, primary, Bellino, Michele, primary, Moreo, Antonella, primary, Casadei, Francesca, primary, Carbone, Andreina, primary, Rega, Salvatore, primary, Citro, Rodolfo, primary, Sangiuolo, Raffaele, primary, Cittadini, Antonio, primary, Bossone, Eduardo, primary, and Marra, Alberto M., primary

Published
2024
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33. Right Ventricular Functional Reserve in Early-Stage Idiopathic Pulmonary Fibrosis: An Exercise Two-Dimensional Speckle Tracking Doppler Echocardiography Study

Author

Bossone, Eduardo, Gargani, Luna, Naeije, Robert, Ferrara, Francesco, Armstrong, William F., Kolias, Theodore John, Caliendo, Luigi, Cocchia, Rosangela, Citro, Rodolfo, Bellino, Michele, Radano, Ilaria, Cittadini, Antonio, D’Alto, Michele, Argiento, Paola, D’Andrea, Antonello, Carbone, Andreina, Sperlongano, Simona, Dellegrottaglie, Santo, De Luca, Nicola, Grazia, Montuori Maria, Rozza, Francesco, Russo, Valentina, Di Salvo, Giovanni, Ghio, Stefano, Grunig, Ekkerard, Marra, Alberto, Guazzi, Marco, Bandera, Francesco, Labate, Valentina, La Gerche, André, Limongelli, Giuseppe, Pacileo, Giuseppe, Verrengia, Marina, Kasprzak, Jaroslaw D., Wierzbowska Drabik, Karina, Kovacs, Gabor, Lancellotti, Patrizio, Moreo, Antonella, Casadei, Francesca, De Chiara, Benedetta, Ostenfeld, Ellen, Pieri, Francesco, Pratali, Lorenza, Saggar, Rajan, Saggar, Rajeev, Selton-Suty, Christine, Huttin, Olivier, Venner, Clément, Serra, Walter, Stanziola, Anna, Martino, Maria, Caccavo, Giovanna, Szabó, István, Varga, Albert, Agoston, Gergely, Voilliot, Darmien, Vriz, Olga, Galzerano, Domenico, Scalese, Marco, Carannante, Luca, Stanziola, Anna Agnese, and Conte, Marianna

Published
2019
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34. Aortic Stenosis and the Evolution of Cardiac Damage after Transcatheter Aortic Valve Replacement.

Author

Islas, Fabián, O'Neill-González, Patrick, Jiménez-Quevedo, Pilar, Nombela-Franco, Luis, Gil-Abizanda, Sandra, Mahía-Casado, Patricia, Rivadeneira-Ruiz, María, Pozo-Osinalde, Eduardo, Carbone, Andreina, and Olmos, Carmen

Subjects
HEART valve prosthesis implantation, MITRAL valve insufficiency, AORTIC stenosis, GLOBAL longitudinal strain, HEART valve diseases, CHRONIC kidney failure
Abstract

Background/Objectives: Severe aortic stenosis (AS) is the most frequent valvular heart disease. Models for stratifying cardiac damage associated with aortic stenosis have been developed to predict outcomes following valve replacement. However, evidence regarding morphological and functional evolution, as well as potential changes in the degree of cardiac damage, is limited. We aim to provide information on the evolution of cardiac morphology and the function of patients undergoing transcatheter aortic valve replacement (TAVR) who have been classified using a cardiac damage staging system. Methods: In total, 496 patients were included in the analysis, and were classified into four stages based on the extent of cardiac damage as follows: Stage 0, no cardiac damage: left ventricle global longitudinal strain (LV-GLS) < −17%; right ventricular–arterial coupling (RVAc) ≥ 0.35), and absence of significant mitral regurgitation (MR). Stage 1, left-sided subclinical damage: LV-GLS ≥ −17%. Stage 2, left-sided damage: significant MR. Stage 3, right-sided damage: RVAc < 0.35. Results: The mean age was 82.1 ± 5.9 years, and 53.0% were female. In total, 24.5% of patients met the criteria for Stage 0, and Stage 1 included 42.8% of patients, Stage 2 included 16.5%, and Stage 3 comprised 16.2% of patients. Mortality was 8.4% for stage 0, 17.4% for stage 1, 25.6% for stage 2, and 28.6% for stage 3 patients (p = 0.004). Diabetes mellitus (DM) (p = 0.047) and chronic kidney disease (CKD) (p = 0.024) were the only clinical predictors of no change or worsening in the stage of cardiac damage. Regarding echocardiographic variables, concomitant tricuspid, and mitral regurgitation, ≥ 2 were both significantly associated with no change or worsening, also (p < 0.001). Conclusions: Cardiac damage that is secondary to severe aortic stenosis has morphological and functional repercussions that, even after valve replacement, persist and might worsen the prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Exercise Stress Echocardiography of the Right Ventricle and Pulmonary Circulation

Author

Gargani, Luna, primary, Pugliese, Nicola Riccardo, additional, De Biase, Nicolò, additional, Mazzola, Matteo, additional, Agoston, Gergely, additional, Arcopinto, Michele, additional, Argiento, Paola, additional, Armstrong, William F., additional, Bandera, Francesco, additional, Cademartiri, Filippo, additional, Carbone, Andreina, additional, Castaldo, Rossana, additional, Citro, Rodolfo, additional, Cocchia, Rosangela, additional, Codullo, Veronica, additional, D’Alto, Michele, additional, D'Andrea, Antonello, additional, Douschan, Philipp, additional, Fabiani, Iacopo, additional, Ferrara, Francesco, additional, Franzese, Monica, additional, Frumento, Paolo, additional, Ghio, Stefano, additional, Grünig, Ekkehard, additional, Guazzi, Marco, additional, Kasprzak, Jaroslaw D., additional, Kolias, Theodore, additional, Kovacs, Gabor, additional, La Gerche, André, additional, Limogelli, Giuseppe, additional, Marra, Alberto Maria, additional, Matucci-Cerinic, Marco, additional, Mauro, Ciro, additional, Moreo, Antonella, additional, Pratali, Lorenza, additional, Ranieri, Brigida, additional, Rega, Salvatore, additional, Rudski, Lawrence, additional, Saggar, Rajan, additional, Salzano, Andrea, additional, Serra, Walter, additional, Stanziola, Anna A., additional, Vannan, Mani A., additional, Voilliot, Damien, additional, Vriz, Olga, additional, Wierzbowska-Drabik, Karina, additional, Cittadini, Antonio, additional, Naeije, Robert, additional, Bossone, Eduardo, additional, Gargani, Luna, additional, Kolias, Theodore John, additional, Capone, Valentina, additional, Sepe, Chiara, additional, Capuano, Francesco, additional, Benvenga, Rossella, additional, Bellino, Michele, additional, Iuliano, Giuseppe, additional, Migliarino, Serena, additional, Radano, Ilaria, additional, Marra, Alberto, additional, Crisci, Giulia, additional, D’Assante, Roberta, additional, De Luca, Mariarosaria, additional, Giardino, Federica, additional, Rainone, Carmen, additional, Valente, Valeria, additional, D’Andrea, Antonello, additional, Russo, Valentina, additional, Dellegrottaglie, Santo, additional, Di Salvo, Giovanni, additional, Guida, Stefania, additional, Grunig, Ekkerard, additional, Eichstaedt, Christina A., additional, Labate, Valentina, additional, La Gerch, André, additional, Limongelli, Giuseppe, additional, Pacileo, Giuseppe, additional, Verrengia, Marina, additional, Casadei, Francesca, additional, De Chiara, Benedetta, additional, Ostenfeld, Ellen, additional, Pedrizzetti, Gianni, additional, Pieri, Francesco, additional, Mori, Fabio, additional, Moggi-Pignone, Alberto, additional, Raciti, Mauro, additional, Pugliese, Nicola, additional, D’Angelo, Gennaro, additional, Stanziola, Anna Agnese, additional, Rossella, D’Angelo, additional, Gallotta, Lorena, additional, Szabó, István, additional, Varga, Albert, additional, Galzerano, Domenico, additional, Vannan, Mani, additional, Mobasseri, Sara, additional, Flueckiger, Peter, additional, and Liu, Shizhen, additional

Published
2023
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38. Health-Related Quality of Life in Patients with Aortic Dissection: An Unmet Need

Author

Carbone, Andreina, primary, Palladino, Raffaele, additional, Franzese, Monica, additional, Castaldo, Rossana, additional, Ranieri, Brigida, additional, Crisci, Giulia, additional, Izzo, Raffaele, additional, Esposito, Giovanni, additional, Cittadini, Antonio, additional, Schreurs, Bibi, additional, van Kimmenade, Roland R.J., additional, and Bossone, Eduardo, additional

Published
2023
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40. Cardiovascular Effects of Weight Loss in Obese Patients with Diabetes: Is Bariatric Surgery the Additional Arrow in the Quiver?

Author

Bottino, Roberta, primary, Carbone, Andreina, additional, Formisano, Tiziana, additional, D’Elia, Saverio, additional, Orlandi, Massimiliano, additional, Sperlongano, Simona, additional, Molinari, Daniele, additional, Castaldo, Pasquale, additional, Palladino, Alberto, additional, Barbareschi, Consiglia, additional, Tolone, Salvatore, additional, Docimo, Ludovico, additional, and Cimmino, Giovanni, additional

Published
2023
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44. Inter‐center reproducibility of standard and advanced echocardiographic parameters in the EACVI‐AFib echo registry

Author

Santoro, Ciro, primary, Donal, Erwan, additional, Magne, Julien, additional, Sade, Leyla Elif, additional, Penicka, Martin, additional, Katbeh, Asim, additional, Cosyns, Bernard, additional, Cameli, Matteo, additional, Hanzevacki, Jadranka Separovic, additional, Luksic, Vlatka Reskovic, additional, Agricola, Eustachio, additional, Citro, Rodolfo, additional, Hagendorff, Andreas, additional, Lancellotti, Patrizio, additional, Habib, Gilbert, additional, Moreo, Antonella, additional, Cardim, Nuno, additional, Parato, Vito Maurizio, additional, Neskovic, Alexsandar, additional, Rosca, Monica, additional, Galli, Elena, additional, Motoc, Andreea, additional, Mandoli, Giulia, additional, Ingallina, Giacomo, additional, Prota, Costantina, additional, Stoebe, Stephen, additional, Piette, Caroline, additional, Mouhat, Basile, additional, Carbone, Andreina, additional, Chiara, Benedetta De, additional, Ilardi, Federica, additional, Stankovic, Ivan, additional, Zamorano, Jose Luis, additional, Popescu, Bogdan Alexandru, additional, Edvardsen, Thor, additional, and Galderisi, Maurizio, additional

Published
2023
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45. Exploring the physiologic variations and related determinants of left ventricular diastolic function among 381 healthy Caucasian adults by the 2016 American Society of Echocardiography–European Association of Cardiovascular Imaging guidelines.

Author

Losi, Maria Angela, Bossone, Eduardo, Piccolo, Raffaele, Canciello, Grazia, Pacella, Daniela, Crisci, Giulia, Carbone, Andreina, Ferrara, Francesco, Izzo, Raffaele, Esposito, Giovanni, and Cittadini, Antonio

Published
2024
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47. Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment

Author

Mauro, Ciro, primary, Capone, Valentina, additional, Cocchia, Rosangela, additional, Cademartiri, Filippo, additional, Riccardi, Ferdinando, additional, Arcopinto, Michele, additional, Alshahid, Maie, additional, Anwar, Kashif, additional, Carafa, Mariano, additional, Carbone, Andreina, additional, Castaldo, Rossana, additional, Chianese, Salvatore, additional, Crisci, Giulia, additional, D’Assante, Roberta, additional, De Luca, Mariarosaria, additional, Franzese, Monica, additional, Galzerano, Domenico, additional, Maffei, Vincenzo, additional, Marra, Alberto M., additional, Valente, Valeria, additional, Giardino, Federica, additional, Mazza, Alfredo, additional, Ranieri, Brigida, additional, D’Agostino, Anna, additional, Rega, Salvatore, additional, Romano, Luigia, additional, Scagliarini, Sarah, additional, Sepe, Chiara, additional, Vriz, Olga, additional, Izzo, Raffaele, additional, Cittadini, Antonio, additional, Bossone, Eduardo, additional, and Salzano, Andrea, additional

Published
2023
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49. Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways

Author

Mauro, Ciro, primary, Capone, Valentina, additional, Cocchia, Rosangela, additional, Cademartiri, Filippo, additional, Riccardi, Ferdinando, additional, Arcopinto, Michele, additional, Alshahid, Maie, additional, Anwar, Kashif, additional, Carafa, Mariano, additional, Carbone, Andreina, additional, Castaldo, Rossana, additional, Chianese, Salvatore, additional, Crisci, Giulia, additional, D’Assante, Roberta, additional, De Luca, Mariarosaria, additional, Franzese, Monica, additional, Galzerano, Domenico, additional, Maffei, Vincenzo, additional, Marra, Alberto Maria, additional, Mazza, Alfredo, additional, Ranieri, Brigida, additional, D’Agostino, Anna, additional, Rega, Salvatore, additional, Romano, Luigia, additional, Scagliarini, Sarah, additional, Sepe, Chiara, additional, Vriz, Olga, additional, Izzo, Raffaele, additional, Cittadini, Antonio, additional, Bossone, Eduardo, additional, and Salzano, Andrea, additional

Published
2023
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50. Current Views on Infective Endocarditis: Changing Epidemiology, Improving Diagnostic Tools and Centering the Patient for Up-to-Date Management

Author

Cimmino, Giovanni, primary, Bottino, Roberta, additional, Formisano, Tiziana, additional, Orlandi, Massimiliano, additional, Molinari, Daniele, additional, Sperlongano, Simona, additional, Castaldo, Pasquale, additional, D’Elia, Saverio, additional, Carbone, Andreina, additional, Palladino, Alberto, additional, Forte, Lavinia, additional, Coppolino, Francesco, additional, Torella, Michele, additional, and Coppola, Nicola, additional

Published
2023
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