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The European research vessel fleet plays a vital role in supporting scientific research and development not just in Europe but also across the globe. This document explores how the fleet has developed since the publication of the European Marine Board Position Paper 10 (EMB PP 10) "European Ocean Research Fleets – Towards a Common Strategy and Enhanced Use" (Binot et al., 2007). It looks at the current fleet and its equipment and capabilities (Chapter 2), the deep sea (Chapter 3) and Polar regions (Chapter 4) as study areas of ever- increasing importance for science and for the vessels that explore them, the role that research vessels play in the wider ocean observing landscape (Chapter 5), the importance of training personnel for research vessels (Chapter 6), and considers management of the European research vessel fleet (Chapter 7). This Position Paper considers what has changed since 2007, what the status is in 2019, and future directions for the European fleet, with a 10-year horizon to 2030. This Position Paper finds that the current European research vessel fleet is highly capable, and is able to provide excellent support to European marine science and wider scientific research and can lead on the world stage. However, with a typical life expectancy of a research vessel of 30 years, the fleet is ageing and urgently requires further investment and reinvestment to continue to be as efficient and capable as the scientific community expects and requires. The capabilities of the fleet have increased considerably since 2007, and vessels have kept up with fast-paced technological developments. The demand for complex and highly capable vessels will continue, and research vessel designs and the fleet as a whole will need to keep pace in order to remain fit-for-purpose and continue to be a key player globally. There is huge diversity in vessel types and designs in terms of capabilities and equipment, management structures and processes, and training possibilities. While

Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, as they can largely rescue these Cdx mutant phenotypes. Conversely, posterior (paralog group 13) Hox genes can prematurely arrest posterior axial growth when precociously expressed. Our data suggest that the transition from trunk to tail Hox gene expression successively regulates the construction and termination of axial structures in the mouse embryo. Thus, Hox genes seem to differentially orchestrate posterior expansion of embryonic tissues during axial morphogenesis as an integral part of their function in specifying head-to-tail identity. In addition, we present evidence that Cdx and Hox transcription factors exert these effects by controlling Wnt signaling. Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition., Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, as they can largely rescue these Cdx mutant phenotypes. Conversely, posterior (paralog group 13) Hox genes can prematurely arrest posterior axial growth when precociously expressed. Our data suggest that the transition from trunk to tail Hox gene expression successively regulates the construction and termination of axial structures in the mouse embryo. Thus, Hox genes seem to differentially orchestrate posterior expansion of embryonic tissues during axial morphogenesis as an integral part of their function in specifying head-to-tail identity. In addition, we present evidence that Cdx and Hox transcription factors exert these effects by controlling Wnt signaling. Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition.