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4. Pegylated Interferon (Alone or With Ribavirin) for Chronic Hepatitis C in Haemodialysis Population

Author

Espinosa M, Hernandez J, Arenas M, Carnicer F, Caramelo C, and Fabrizi F

Subjects
Chronic kidney disease, Ribavirin, Dialysis, Hepatitis C, Pegylated interferon
Abstract

Background/Aims: Hepatitis C virus infection remains prevalent among patients undergoing long-term haemodialysis and has a detrimental impact on survival in this population. Antiviral therapy for chronic hepatitis C in haemodialysis patients is still a challenge to clinicians. The aim of the current study is to evaluate the efficacy and safety of therapy with pegylated interferon, alone or combined with ribavirin, for chronic hepatitis C among patients undergoing long-term hemodialysis. Methods: We conducted a retrospective, multicenter cohort trial with monotherapy (pegylated interferon) (n=21) or combined antiviral therapy (pegylated interferon plus ribavirin) (n=5) for chronic hepatitis C in patients undergoing long-term haemodialysis. Results: Sustained virological response was obtained in eleven (42%) patients. Seven (26.9%) patients interrupted prematurely the antiviral treatment due to serious side-effects, the most frequent cause of treatment withdrawal being hematological (n=3). HCV RNA load was lower in responder than non-responder patients, 5.44 (3.45; 6.36) vs. 5.86 (4.61; 6.46) log(10) copies/mL, even if the difference was not significant (P=0.099). Blood transfusion requirement was greater in patients on combined antiviral therapy than those on pegylated interferon alone, 100% (5/5) vs. 0% (0/21), P=0.0001. No difference in sustained viral response occurred between patients on combined antiviral therapy and those on pegylated interferon monotherapy [40% (2/5) vs. 42.8% (9/21), P=0.90]. Conclusions: Results from this study showed that pegylated interferon alone or with ribavirin is unsatisfactory in terms of efficacy and safety. Prospective trials based on interferon-free regimens (i.e., sofosbuvir plus ribavirin or sofosbuvir plus daclatasvir) are under way in patients with hepatitis C receiving long-term hemodialysis. Copyright (C) 2015 S. Karger AG, Basel

Published
2015

5. [Reticulocyte response after immediate withdrawal of recombinant human erythropoietin in chronic hemodialysis patients]

Author

Caramelo C, Soto C, Neira F, Md, López, Jiménez S, Albalate M, de Oña R, Llamas P, and Jj, Deudero

Subjects
Doping in Sports, Male, Anemia, Middle Aged, Drug Administration Schedule, Recombinant Proteins, Rats, Epoetin Alfa, Hematocrit, Reticulocyte Count, Recurrence, Renal Dialysis, Animals, Humans, Kidney Failure, Chronic, Erythropoiesis, Female, Rats, Wistar, Erythropoietin, Aged, Uremia
Abstract

The sudden interruption of recombinant human erythropoietin (rHuEPO) in end-stage renal disease (ESRD) patients leads to rapid anemization. The mechanisms of this phenomenon are, however, insufficiently understood. The present study examined the response to immediate rHuEPO withdrawal in dialysis patients.10 chronic hemodialysis (HD) patients regularly receiving rHuEPO were studied. rHuEPO was stopped and reinitiated after 7 days. Reticulocyte profile, haemoglobin and haematocrit were measured at 0, 7 and 15 days. As a complementary study, and with the purpose of analyzying whether uremia was a relevant factor, 10 non-uremic male Wistar rats were treated with rHuEPO. After two weeks, rHuEPO was withdrawn in 5 animals, and continued for 7 additional days in the remainder. The same variables than in the human study were determined.Changes in reticulocyte subtypes from baseline to day 7 were: total 18.2 +/- 0.9 vs 14.3 +/- 1.8% (p0.06); high-fluorescence (HFR): 2.6 +/- 0.4 vs 0.75 +/- 0.2 (p0.001); medium-fluorescence (MFR): 13.0 +/- 1.1 vs 6.6 +/- 0.9% (p0.02); and low-fluorescence (LFR): 84.2 +/- 1.4 vs 92.7 +/- 1% (p NS). The baseline pattern was recovered upon 7 days of rHuEPO reinitiation (p NS). Mean hemoglobin and hematocrit decreased by day 14 (p0.02) in spite of rHuEPO reinitiation at day 7. In non-uremic rats, changes were similar to that in the ESRD patients.rHuEPO induces changes in the reticulocyte pattern, consisting in a reduction of immature reticulocytes. These changes appear to be independent of the presence of uremia. Accordingly, complete rHuEPO withdrawal in HD patients will cause a rapidly-developing anaemia due to an alteration in the reticulocyte maturation series; therefore, sudden rHuEPO interruption should be avoided whenever is possible. As a collateral application, the specific changes described herein have potential use for detecting illegal administration of rHuEPO.

Published
2004

6. [Role of VEGF in the cellular response to injury]

Author

Mv, Alvarez-Arroyo, Yagüe S, Fr, González-Pacheco, Ma, Castilla, Suzuki Y, Jiménez S, Jj, Deudero, Neria F, Velasco L, and Caramelo C

Subjects
Vascular Endothelial Growth Factor A, Clinical Trials as Topic, Lymphokines, Vascular Endothelial Growth Factors, Animals, Blood Vessels, Humans, Intercellular Signaling Peptides and Proteins, Cattle, Endothelial Growth Factors, Endothelium, Vascular
Published
2003

12. Reply

Author

Albalate, M., primary and Caramelo, C., additional

Published
2006
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28. Role of Endothelium-Related Mechanisms in the Pathophysiology of Renal Ischemia/Reperfusion in Normal Rabbits

Author

Caramelo, C., primary, Espinosa, G., additional, Manzarbeitia, F., additional, Cernadas, M.R., additional, Tejerizo, G. Pe´rez, additional, Tan, D., additional, Mosquera, J.R., additional, Digiuni, E., additional, Monto´n, M., additional, Milla´s, I., additional, Hernando, L., additional, Casado, S., additional, and Lo´pez-Farre´, A., additional

Published
1996
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35. Effects of Nitric Oxide on Red Blood Cells: Changes in Erythrocyte Resistance to Hypotonic Hemolysis and Potassium Efflux by Experimental Maneuvers That Decrease Nitric Oxide

Author

Caramelo, C., primary, Riesco, A., additional, Outeirino, J., additional, Millas, I., additional, Blum, G., additional, Monzu, B., additional, Casado, V., additional, Sanchez, L., additional, Mosquera, J.R., additional, Casado, S., additional, and Farre, A.L., additional

Published
1994
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41. Morphology and biology of Laetmonice producta producta Grube (Polychaeta: Aphroditidae) in the Bellingshausen Sea and Antarctic Peninsula (Southern Ocean, Antarctica).

Author

Parapar, J., Moreira, J., Gambi, M. C., and Caramelo, C.

Subjects
POLYCHAETA, APHRODITIDAE, BATHYMETRIC maps, ENDOSYMBIOSIS
Abstract

The present paper reports on some morphological and biological features of the scale-wormLaetmonice producta productaGrube, 1877 (Polychaeta: Aphroditidae) in the northwestern sector of Antarctica. A total of 114 specimens were collected during the 2003 and 2006 cruises of the BENTART project on the shelf and upper slope of the Antarctic Peninsula and the Bellingshausen Sea. Specimens were collected using an Agassiz trawl at 22 stations covering a depth ranging from 115 to 1431 m. Bathymetric distribution, abundance and sizes, diet, presence of endosymbionts and epibionts, and some observations related to parapodial structure and chaetal types are discussed in relation to taxonomy and environmental characteristics and compared to previous data. [ABSTRACT FROM PUBLISHER]

Published
2013
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42. Liver Disease Patterns in Hemodialysis Patients With Antibodies to Hepatitis C Virus

Author

Caramelo, C., primary, Ortiz, A., additional, Aguilera, B., additional, Porres, J.C., additional, Navas, S., additional, Marriott, E., additional, Alberola, M.L., additional, Alamo, C., additional, Galera, A., additional, Garreño, M.P., additional, Gonzalez-Parra, E., additional, Fernández de Gabriel, M.V., additional, Oliva, H., additional, and Carreflo, V., additional

Published
1993
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43. Correlation among carboxiterminal cross-linked telopeptide of type I collagen (ICTP), new serum biochemical marker of bone resorption, serum tatrate resistant acid phosphatase (TRAP), and serum levels of intact parathyroid hormone in parathyroid hyperfunction

Author

de la Piedra, C., primary, Martín, M.Å.Díaz, additional, Diego, E.M.Díaz, additional, Gavilanes, E.López, additional, Parra, E.González, additional, Caramelo, C., additional, and Rapado, Å., additional

Published
1993
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