1. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
- Author
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Nuytemans, Karen, Franzen, Sanne, Broce, Iris J, Caramelli, Paulo, Ellajosyula, Ratnavalli, Finger, Elizabeth, Gupta, Veer, Gupta, Vivek, Illán‐Gala, Ignacio, Loi, Samantha M, Morhardt, Darby, Pijnenburg, Yolande, Rascovsky, Katya, Williams, Monique M, Yokoyama, Jennifer S, Acosta‐Uribe, Juliana, Akinyemi, Rufus, Alladi, Suvarna, Ayele, Biniyam A, Ayhan, Yavuz, Bourdage, Renelle, Castro‐Suarez, Sheila, de Souza, Leonardo Cruz, Dacks, Penny, de Boer, Sterre CM, de Leon, Jessica, Dodge, Shana, Grasso, Stephanie, Ghoshal, Nupur, Kamath, Vidyulata, Kumfor, Fiona, Matias‐Guiu, Jordi A, Narme, Pauline, Nielsen, T Rune, Okhuevbie, Daniel, Piña‐Escudero, Stefanie, Ruiz‐Garcia, Ramiro, Ryan, Brigid, Scarioni, Marta, Slachevsky, Andrea, Suarez‐Gonzalez, Aida, Tee, Boon Lead, Tsoy, Elena, Ulugut, Hulya, Onyike, Chiadi U, Babulal, Ganesh M, and PIA, ISTAART Diversity and Disparities PIA ISTAART Frontotemporal Dementia and Related Disorders
- Subjects
Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Frontotemporal Dementia (FTD) ,Dementia ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurodegenerative ,Brain Disorders ,Alzheimer's Disease Related Dementias (ADRD) ,Rare Diseases ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Aphasia ,Aging ,Behavioral and Social Science ,Neurological ,Humans ,Frontotemporal Dementia ,Biomedical Research ,Healthcare Disparities ,Cultural Diversity ,biomarkers ,cultural diversity ,epidemiology ,ethnicity ,frontotemporal dementia ,genetics ,infrastructure ,ISTAART Frontotemporal Dementia and Related Disorders PIA ,ISTAART Diversity and Disparities PIA ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross-cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.
- Published
- 2024