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1. Tolerance and autoimmunity: novel therapeutic approaches

Author

Ciliberti, Esteban, Carambia, Leandro, Cavallin, Sebastian, Cerda, Osvaldo L., Poderoso, Juan J., and Rabinovich, Gabriel Adrián

Subjects
Medicina Básica, HOMEOSTASIS, CIENCIAS MÉDICAS Y DE LA SALUD, AUTOIMMUNE DISEASES, SELF TOLERANCE, TOLERANCIA, purl.org/becyt/ford/3 [https], purl.org/becyt/ford/3.1 [https], Bioquímica y Biología Molecular, AUTOINMUNIDAD, INMUNOFARMACOLOGÍA, GALECTINS
Abstract

La función primaria del sistema inmune es resguardar al individuo de los patógenos potencialmente dañinos que invaden el medio ambiente en el cual nos desarrollamos. Este cuenta con dos grandes ramas, la inmunidad innata y la adaptativa, ambas con la propiedad de diferenciar lo peligroso de aquello inofensivo. Estos procesos se hallan regulados por mecanismos homeostáticos que constituyen la tolerancia inmunológica, a los fines de limitar aquellos procesos prolongados y silenciar los potencialmente autoagresivos. Ante la falla de estos mecanismos de control, surgen las enfermedades autoinmunes. Avances en el conocimiento de la fisiopatología de estas entidades, han abierto un nuevo capítulo en el terreno de la inmunofarmacología. Su prometedor potencial actualmente nos ofrece novedosas herramientas terapéuticas para controlar y atenuar el daño causado por este tipo de respuestas. No obstante, debe continuarse la investigación en el campo de los agentes biológicos, ya que ninguno de ellos se encuentra libre de inconvenientes. Seguramente, futuros hallazgos se concretarán en futuros aciertos. Y los aciertos, en Medicina, equivalen a esperanza. The main function of the immune system is to protect the individual against potentially dangerous pathogens. It comprises innate and adaptive cellular and soluble components, both with the capacity to discriminate between harmful and harmless. These processes are regulated by homeostatic mechanisms that constitute the so-called immunological tolerance, which aims to limit the prolonged action of immune mediators and to silence the generation of potentially autoaggressive components. Failure to silence self-reactive T and B cells results in the generation of autoimmune disease. Recent advances in our knowledge of these pathological entities have opened a new chapter in the pharmacology of the immune system. Its promising potential currently offers new therapeutic agents to control and attenuate pathological tissue damage. Nevertheless, further research regarding these biologic agents is required, since they are not free from inconveniences. It is without question that upcoming findings in this field will instill hope into the quest for the “magic bullet”. Fil: Ciliberti, Esteban. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Carambia, Leandro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina Fil: Cavallin, Sebastian. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina Fil: Cerda, Osvaldo L.. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Poderoso, Juan J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina

Published
2009

2. CONCEPTOS EMERGENTES DE TOLERANCIA Y AUTOINMUNIDAD NUEVOS ENFOQUES TERAPEUTICOS.

Author

Ciliberti, Esteban, Carambia, Leandro, Cavallin, Sebastian, Cerda, Osvaldo L., Poderoso, Juan J., and Rabinovich, Gabriel A.

Abstract

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2009

3. [Tolerance and autoimmunity. Novel therapeutic approaches].

Author

Ciliberti E, Carambia L, Cavallin S, Cerda OL, Poderoso JJ, and Rabinovich GA

Subjects
Autoimmune Diseases drug therapy, Autoimmunity drug effects, Communicable Diseases drug therapy, Humans, Immune Tolerance drug effects, Autoimmune Diseases immunology, Autoimmunity immunology, Communicable Diseases immunology, Immune Tolerance immunology
Abstract

The main function of the immune system is to protect the individual against potentially dangerous pathogens. It comprises innate and adaptive cellular and soluble components, both with the capacity to discriminate between harmful and harmless. These processes are regulated by homeostatic mechanisms that constitute the so-called immunological tolerance, which aims to limit the prolonged action of immune mediators and to silence the generation of potentially autoaggressive components. Failure to silence self-reactive T and B cells results in the generation of autoimmune disease. Recent advances in our knowledge of these pathological entities have opened a new chapter in the pharmacology of the immune system. Its promising potential currently offers new therapeutic agents to control and attenuate pathological tissue damage. Nevertheless, further research regarding these biologic agents is required, since they are not free from inconveniences. It is without question that upcoming findings in this field will instill hope into the quest for the "magic bullet".

Published
2009

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