347 results on '"Caragounis, A"'
Search Results
2. On Scene Injury Severity Prediction (OSISP) model for trauma developed using the Swedish Trauma Registry
- Author
-
Bakidou, Anna, Caragounis, Eva-Corina, Andersson Hagiwara, Magnus, Jonsson, Anders, Sjöqvist, Bengt Arne, and Candefjord, Stefan
- Published
- 2023
- Full Text
- View/download PDF
3. DORIS study: domestic violence in orthopaedics, a prospective cohort study at a Swedish hospital on the annual prevalence of domestic violence in orthopaedic emergency care
- Author
-
Karin Svensson Malchau, Eva-Corina Caragounis, and Mikael Sundfeldt
- Subjects
Medicine - Abstract
Background Domestic violence (DV) is a major problem which despite many efforts persists globally. Victims of DV can present with various injuries, whereof musculoskeletal presentation is common.Objectives The DORIS study (Domestic violence in ORthopaedIcS) aimed to establish the annual prevalence of DV at an orthopaedic emergency department (ED) in Sweden.Design Female adult patients with orthopaedic injuries seeking treatment at a tertiary orthopaedic centre between September 2021 and 2022 were screened during their ED visit.Setting This is a single-centre study at a tertiary hospital in Sweden.Participants Adult female patients seeking care for acute orthopaedic injuries were eligible for the study. During the study period, 4192 female patients were provided with study forms and 1366 responded (32.5%).Primary and secondary outcome measures The primary outcome measure was to establish the annual prevalence of injuries due to DV and second, to establish the rate of current experience of any type of DV.Results One in 14 had experience of current DV (n=100, 7.5%) and 1 in 65 (n=21, 1.5%) had an injury due to DV.Conclusions The prevalence of DV found in the current study is comparable to international findings and adds to the growing body of evidence that it needs to be considered in clinical practice. It is important to raise awareness of DV, and frame strategies, as healthcare staff have a unique position to identify and offer intervention to DV victims.
- Published
- 2024
- Full Text
- View/download PDF
4. On Scene Injury Severity Prediction (OSISP) model for trauma developed using the Swedish Trauma Registry
- Author
-
Anna Bakidou, Eva-Corina Caragounis, Magnus Andersson Hagiwara, Anders Jonsson, Bengt Arne Sjöqvist, and Stefan Candefjord
- Subjects
Artificial Intelligence (AI) ,Clinical Decision Support System (CDSS) ,On Scene Injury Severity Prediction (OSISP) ,Prehospital care ,Trauma ,Field triage ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Providing optimal care for trauma, the leading cause of death for young adults, remains a challenge e.g., due to field triage limitations in assessing a patient’s condition and deciding on transport destination. Data-driven On Scene Injury Severity Prediction (OSISP) models for motor vehicle crashes have shown potential for providing real-time decision support. The objective of this study is therefore to evaluate if an Artificial Intelligence (AI) based clinical decision support system can identify severely injured trauma patients in the prehospital setting. Methods The Swedish Trauma Registry was used to train and validate five models – Logistic Regression, Random Forest, XGBoost, Support Vector Machine and Artificial Neural Network – in a stratified 10-fold cross validation setting and hold-out analysis. The models performed binary classification of the New Injury Severity Score and were evaluated using accuracy metrics, area under the receiver operating characteristic curve (AUC) and Precision-Recall curve (AUCPR), and under- and overtriage rates. Results There were 75,602 registrations between 2013–2020 and 47,357 (62.6%) remained after eligibility criteria were applied. Models were based on 21 predictors, including injury location. From the clinical outcome, about 40% of patients were undertriaged and 46% were overtriaged. Models demonstrated potential for improved triaging and yielded AUC between 0.80–0.89 and AUCPR between 0.43–0.62. Conclusions AI based OSISP models have potential to provide support during assessment of injury severity. The findings may be used for developing tools to complement field triage protocols, with potential to improve prehospital trauma care and thereby reduce morbidity and mortality for a large patient population.
- Published
- 2023
- Full Text
- View/download PDF
5. Long-term outcome after surgical management of symptomatic non-union rib fractures
- Author
-
Nilsson, Julia and Caragounis, Eva-Corina
- Published
- 2024
- Full Text
- View/download PDF
6. International registry on aortic balloon occlusion in major trauma: Partial inflation does not improve outcomes in abdominal trauma
- Author
-
Sadeghi, M., Pirouzram, A., Toivola, A., Skoog, P., Idoguchi, K., Kon, Y., Ishida, T., Matsumura, Y., Matsumoto, J., Maszkowski, M., Bersztel, A., Caragounis, E.C., Bachmann, T., Falkenberg, M., Handolin, L., Chang, S.W., Hecht, A., Hebron, D., Shaked, G., Bala, M., Coccolini, F., Ansaloni, L., Hoencamp, R., Özlüer, Y.E., Hilbert-Carius, Peter, Reva, V., Oosthuizen, G., Szarka, E., Manchev, V., Wannatoop, T., Ordoñez, C.A., Larzon, T., Nilsson, K.F., Paran, Maya, McGreevy, David, Hörer, Tal M., Khan, Mansoor, Dudkiewicz, Mickey, and Kessel, Boris
- Published
- 2024
- Full Text
- View/download PDF
7. Management and outcomes of firearm-related vascular injuries
- Author
-
Karolina Nyberger, Eva-Corina Caragounis, Pauline Djerf, and Carl-Magnus Wahlgren
- Subjects
Firearm injury ,Gunshot wound ,Epidemiology ,Vascular injury ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Violence due to firearms is a major global public health issue and vascular injuries from firearms are particularly lethal. The aim of this study was to analyse population-based epidemiology of firearm-related vascular injuries. Methods This was a retrospective nationwide epidemiological study including all patients with firearm injuries from the national Swedish Trauma Registry (SweTrau) from January 1, 2011 to December 31, 2019. There were 71,879 trauma patients registered during the study period, of which 1010 patients were identified with firearm injuries (1.4%), and 162 (16.0%) patients with at least one firearm-related vascular injury. Results There were 162 patients admitted with 238 firearm-related vascular injuries, 96.9% men (n = 157), median age 26.0 years [IQR 22–33]. There was an increase in vascular firearm injuries over time (P
- Published
- 2023
- Full Text
- View/download PDF
8. Injury pattern and clinical outcome in patients with and without chest wall injury after cardiopulmonary resuscitation
- Author
-
Hadesi, Parsa, Rossi Norrlund, Rauni, and Caragounis, Eva-Corina
- Published
- 2023
- Full Text
- View/download PDF
9. Retrospective comparison of operative technique for chest wall injuries
- Author
-
Westin, Erik Öberg, Olsén, Monika Fagevik, Örtenwall, Per, and Caragounis, Eva-Corina
- Published
- 2023
- Full Text
- View/download PDF
10. Surgical stabilization versus nonoperative treatment for flail and non-flail rib fracture patterns in patients with traumatic brain injury
- Author
-
Prins, Jonne T. H., Van Lieshout, Esther M. M., Ali-Osman, Francis, Bauman, Zachary M., Caragounis, Eva-Corina, Choi, Jeff, Christie, III, D. Benjamin, Cole, Peter A., DeVoe, William B., Doben, Andrew R., Eriksson, Evert A., Forrester, Joseph D., Fraser, Douglas R., Gontarz, Brendan, Hardman, Claire, Hyatt, Daniel G., Kaye, Adam J., Ko, Huan-Jang, Leasia, Kiara N., Leon, Stuart, Marasco, Silvana F., McNickle, Allison G., Nowack, Timothy, Ogunleye, Temi D., Priya, Prakash, Richman, Aaron P., Schlanser, Victoria, Semon, Gregory R., Su, Ying-Hao, Verhofstad, Michael H. J., Whitis, Julie, Pieracci, Fredric M., and Wijffels, Mathieu M. E.
- Published
- 2022
- Full Text
- View/download PDF
11. Epidemiology of firearm injuries in Sweden
- Author
-
Nyberger, Karolina, Caragounis, Eva-Corina, Djerf, Pauline, and Wahlgren, Carl-Magnus
- Published
- 2022
- Full Text
- View/download PDF
12. Mortality of trauma patients treated at trauma centers compared to non-trauma centers in Sweden: a retrospective study
- Author
-
Candefjord, Stefan, Asker, Linn, and Caragounis, Eva-Corina
- Published
- 2022
- Full Text
- View/download PDF
13. Favourable outcome in survivors of CPR-related chest wall injuries
- Author
-
Nouh, Micheline Al, primary, Caragounis, Eva-Corina, additional, Norrlund, Rauni Rossi, additional, and Olsén, Monika Fagevik, additional
- Published
- 2024
- Full Text
- View/download PDF
14. DORIS study: domestic violence in orthopaedics, a prospective cohort study at a Swedish hospital on the annual prevalence of domestic violence in orthopaedic emergency care
- Author
-
Svensson Malchau, Karin, primary, Caragounis, Eva-Corina, additional, and Sundfeldt, Mikael, additional
- Published
- 2024
- Full Text
- View/download PDF
15. New Testament Investigations
- Author
-
Caragounis, Chrys C., primary
- Published
- 2022
- Full Text
- View/download PDF
16. Mechanism of injury, injury patterns and associated injuries in patients operated for chest wall trauma
- Author
-
Caragounis, Eva-Corina, Xiao, Yao, and Granhed, Hans
- Published
- 2021
- Full Text
- View/download PDF
17. Long-term outcome after surgical management of symptomatic non-union rib fractures
- Author
-
Nilsson, Julia, primary and Caragounis, Eva-Corina, additional
- Published
- 2023
- Full Text
- View/download PDF
18. Aortic balloon occlusion (REBOA) in pelvic ring injuries: preliminary results of the ABO Trauma Registry
- Author
-
Coccolini, Federico, Ceresoli, Marco, McGreevy, David T., Sadeghi, Mitra, Pirouzram, Artai, Toivola, Asko, Skoog, Per, Idoguchi, Koji, Kon, Yuri, Ishida, Tokiya, Matsumura, Yosuke, Matsumoto, Junichi, Reva, Viktor, Maszkowski, Mariusz, Fugazzola, Paola, Tomasoni, Matteo, Cicuttin, Enrico, Ansaloni, Luca, Zaghi, Claudia, Sibilla, Maria Grazia, Cremonini, Camilla, Bersztel, Adam, Caragounis, Eva-Corina, Falkenberg, Mårten, Handolin, Lauri, Oosthuizen, George, Szarka, Endre, Manchev, Vassil, Wannatoop, Tongporn, Chang, Sung Wook, Kessel, Boris, Hebron, Dan, Shaked, Gad, Bala, Miklosh, Ordoñez, Carlos A., Hibert-Carius, Peter, Chiarugi, Massimo, Nilsson, Kristofer F., Larzon, Thomas, Gamberini, Emiliano, Agnoletti, Vanni, Catena, Fausto, and Hörer, Tal M.
- Published
- 2020
- Full Text
- View/download PDF
19. Retrospective comparison of operative technique for chest wall injuries
- Author
-
Erik Öberg Westin, Monika Fagevik Olsén, Per Örtenwall, and Eva-Corina Caragounis
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Published
- 2023
20. International registry on aortic balloon occlusion in major trauma: Partial inflation does not improve outcomes in abdominal trauma
- Author
-
Paran, Maya, primary, McGreevy, David, additional, Hörer, Tal M., additional, Khan, Mansoor, additional, Dudkiewicz, Mickey, additional, Kessel, Boris, additional, Sadeghi, M., additional, Pirouzram, A., additional, Toivola, A., additional, Skoog, P., additional, Idoguchi, K., additional, Kon, Y., additional, Ishida, T., additional, Matsumura, Y., additional, Matsumoto, J., additional, Maszkowski, M., additional, Bersztel, A., additional, Caragounis, E.C., additional, Bachmann, T., additional, Falkenberg, M., additional, Handolin, L., additional, Chang, S.W., additional, Hecht, A., additional, Hebron, D., additional, Shaked, G., additional, Bala, M., additional, Coccolini, F., additional, Ansaloni, L., additional, Hoencamp, R., additional, Özlüer, Y.E., additional, Hilbert-Carius, Peter, additional, Reva, V., additional, Oosthuizen, G., additional, Szarka, E., additional, Manchev, V., additional, Wannatoop, T., additional, Ordoñez, C.A., additional, Larzon, T., additional, and Nilsson, K.F., additional
- Published
- 2023
- Full Text
- View/download PDF
21. Management and outcomes of firearm-related vascular injuries
- Author
-
Nyberger, Karolina, primary, Caragounis, Eva-Corina, additional, Djerf, Pauline, additional, and Wahlgren, Carl-Magnus, additional
- Published
- 2023
- Full Text
- View/download PDF
22. The Development of Greek and the New Testament
- Author
-
Caragounis, Chrys C., primary
- Published
- 2019
- Full Text
- View/download PDF
23. The Son of Man
- Author
-
Caragounis, Chrys C., primary
- Published
- 2019
- Full Text
- View/download PDF
24. New Testament Language and Exegesis
- Author
-
Caragounis, Chrys C., primary
- Published
- 2019
- Full Text
- View/download PDF
25. The use of aortic balloon occlusion in traumatic shock: first report from the ABO trauma registry
- Author
-
Sadeghi, M., Nilsson, K. F., Larzon, T., Pirouzram, A., Toivola, A., Skoog, P., Idoguchi, K., Kon, Y., Ishida, T., Matsumara, Y., Matsumoto, J., Reva, V., Maszkowski, M., Bersztel, A., Caragounis, E., Falkenberg, M., Handolin, L., Kessel, B., Hebron, D., Coccolini, F., Ansaloni, L., Madurska, M. J., Morrison, J. J., and Hörer, T. M.
- Published
- 2018
- Full Text
- View/download PDF
26. Surgical stabilization versus nonoperative treatment for flail and non-flail rib fracture patterns in patients with traumatic brain injury
- Author
-
Jonne T. H. Prins, Esther M. M. Van Lieshout, Francis Ali-Osman, Zachary M. Bauman, Eva-Corina Caragounis, Jeff Choi, D. Benjamin Christie, Peter A. Cole, William B. DeVoe, Andrew R. Doben, Evert A. Eriksson, Joseph D. Forrester, Douglas R. Fraser, Brendan Gontarz, Claire Hardman, Daniel G. Hyatt, Adam J. Kaye, Huan-Jang Ko, Kiara N. Leasia, Stuart Leon, Silvana F. Marasco, Allison G. McNickle, Timothy Nowack, Temi D. Ogunleye, Prakash Priya, Aaron P. Richman, Victoria Schlanser, Gregory R. Semon, Ying-Hao Su, Michael H. J. Verhofstad, Julie Whitis, Fredric M. Pieracci, Mathieu M. E. Wijffels, and Surgery
- Subjects
Fracture Fixation, Internal ,Rib Fractures ,Brain Injuries, Traumatic ,Flail Chest ,Emergency Medicine ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Pneumonia ,Length of Stay ,Critical Care and Intensive Care Medicine ,Retrospective Studies - Abstract
Purpose Literature on outcomes after SSRF, stratified for rib fracture pattern is scarce in patients with moderate to severe traumatic brain injury (TBI; Glasgow Coma Scale ≤ 12). We hypothesized that SSRF is associated with improved outcomes as compared to nonoperative management without hampering neurological recovery in these patients. Methods A post hoc subgroup analysis of the multicenter, retrospective CWIS-TBI study was performed in patients with TBI and stratified by having sustained a non-flail fracture pattern or flail chest between January 1, 2012 and July 31, 2019. The primary outcome was mechanical ventilation-free days and secondary outcomes were in-hospital outcomes. In multivariable analysis, outcomes were assessed, stratified for rib fracture pattern. Results In total, 449 patients were analyzed. In patients with a non-flail fracture pattern, 25 of 228 (11.0%) underwent SSRF and in patients with a flail chest, 86 of 221 (38.9%). In multivariable analysis, ventilator-free days were similar in both treatment groups. For patients with a non-flail fracture pattern, the odds of pneumonia were significantly lower after SSRF (odds ratio 0.29; 95% CI 0.11–0.77; p = 0.013). In patients with a flail chest, the ICU LOS was significantly shorter in the SSRF group (beta, − 2.96 days; 95% CI − 5.70 to − 0.23; p = 0.034). Conclusion In patients with TBI and a non-flail fracture pattern, SSRF was associated with a reduced pneumonia risk. In patients with TBI and a flail chest, a shorter ICU LOS was observed in the SSRF group. In both groups, SSRF was safe and did not hamper neurological recovery.
- Published
- 2022
27. Retrospective comparison of operative technique for chest wall injuries
- Author
-
Öberg Westin, Erik, primary, Fagevik Olsén, Monika, additional, Örtenwall, Per, additional, and Caragounis, Eva-Corina, additional
- Published
- 2023
- Full Text
- View/download PDF
28. Aortic balloon occlusion (REBOA) in pelvic ring injuries: preliminary results of the ABO Trauma Registry
- Author
-
Coccolini, Federico, Ceresoli, Marco, McGreevy, David T., Sadeghi, Mitra, Pirouzram, Artai, Toivola, Asko, Skoog, Per, Idoguchi, Koji, Kon, Yuri, Ishida, Tokiya, Matsumura, Yosuke, Matsumoto, Junichi, Reva, Viktor, Maszkowski, Mariusz, Fugazzola, Paola, Tomasoni, Matteo, Cicuttin, Enrico, Ansaloni, Luca, Zaghi, Claudia, Sibilla, Maria Grazia, Cremonini, Camilla, Bersztel, Adam, Caragounis, Eva-Corina, Falkenberg, Mårten, Handolin, Lauri, Oosthuizen, George, Szarka, Endre, Manchev, Vassil, Wannatoop, Tongporn, Chang, Sung Wook, Kessel, Boris, Hebron, Dan, Shaked, Gad, Bala, Miklosh, Ordoñez, Carlos A., Hibert-Carius, Peter, Chiarugi, Massimo, Nilsson, Kristofer F., Larzon, Thomas, Gamberini, Emiliano, Agnoletti, Vanni, Catena, Fausto, and Hörer, Tal M.
- Abstract
EndoVascular and Hybrid Trauma Management (EVTM) has been recently introduced in the treatment of severe pelvic ring injuries. This multimodal method of hemorrhage management counts on several strategies such as the REBOA (resuscitative endovascular balloon occlusion of the aorta). Few data exist on the use of REBOA in patients with a severely injured pelvic ring. The ABO (aortic balloon occlusion) Trauma Registry is designed to capture data for all trauma patients in hemorrhagic shock where management includes REBOA placement. Among all patients included in the ABO registry, 72 patients presented with severe pelvic injuries and were the population under exam. 66.7% were male. Mean and median ISS were respectively 43 and 41 (SD ± 13). Isolated pelvic injuries were observed in 12 patients (16.7%). Blunt trauma occurred in 68 patients (94.4%), penetrating in 2 (2.8%) and combined in 2 (2.8%). Type of injury: fall from height in 15 patients (23.1%), traffic accident in 49 patients (75.4%), and unspecified impact in 1 patient (1.5%). Femoral access was gained pre-hospital in 1 patient, in emergency room in 43, in operating room in 12 and in angio-suite in 16. REBOA was positioned in zone 1 in 59 patients (81,9%), in zone 2 in 1 (1,4%) and in zone 3 in 12 (16,7%). Aortic occlusion was partial/periodical in 35 patients (48,6%) and total occlusion in 37 patients (51,4%). REBOA associated morbidity rate: 11.1%. Overall mortality rate was 54.2% and early mortality rate (≤ 24 h) was 44.4%. In the univariate analysis, factors related to early mortality (≤ 24 h) are lower pH values (p= 0.03), higher base deficit (p= 0.021), longer INR (p= 0.012), minor increase in systolic blood pressure after the REBOA inflation (p= 0.03) and total aortic occlusion (p= 0.008). None of these values resulted significant in the multivariate analysis. In severe hemodynamically unstable pelvic trauma management, REBOA is a viable option when utilized in experienced centers as a bridge to other treatments; its use might be, however, accompanied with severe-to-lethal complications.
- Published
- 2024
- Full Text
- View/download PDF
29. Surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures following cardiopulmonary resuscitation: An international, retrospective matched case-control study
- Author
-
Jonne T.H. Prins, Esther M.M. Van Lieshout, Evert A. Eriksson, Matthew Barnes, Taco J. Blokhuis, Eva-Corina Caragounis, D. Benjamin Christie, Erik R. De Loos, William B. DeVoe, Henk A. Formijne Jonkers, Brandon Kiel, Huan-Jang Ko, Silvana F. Marasco, Willem R. Spanjersberg, Ying-Hao Su, Robyn G. Summerhayes, Pieter J. Van Huijstee, Jefrey Vermeulen, Dagmar I. Vos, Michael H.J. Verhofstad, Mathieu M.E. Wijffels, Surgery, MUMC+: MA Heelkunde (9), and RS: NUTRIM - R3 - Respiratory & Age-related Health
- Subjects
Treatment Outcome ,Rib Fractures ,Case-Control Studies ,Humans ,Spinal Fractures ,Surgery ,Length of Stay ,Critical Care and Intensive Care Medicine ,Retrospective Studies - Abstract
BACKGROUND: The presence of six or more rib fractures or a displaced rib fracture due to cardiopulmonary resuscitation (CPR) has been associated with longer hospital and intensive care unit (ICU) length of stay (LOS). Evidence on the effect of surgical stabilization of rib fractures (SSRF) following CPR is limited. This study aimed to evaluate outcomes after SSRF versus nonoperative management in patients with multiple rib fractures after CPR. METHODS: An international, retrospective study was performed in patients who underwent SSRF or nonoperative management for multiple rib fractures following CPR between January 1, 2012, and July 31, 2020. Patients who underwent SSRF were matched to nonoperative controls by cardiac arrest location and cause, rib fracture pattern, and age. The primary outcome was ICU LOS. RESULTS: Thirty-nine operatively treated patient were matched to 66 nonoperatively managed controls with comparable CPR-related characteristics. Patients who underwent SSRF more often had displaced rib fractures (n = 28 [72%] vs. n = 31 [47%]; p = 0.015) and a higher median number of displaced ribs (2 [P 25 -P 75 , 0-3] vs. 0 [P 25 -P 75 , 0-3]; p = 0.014). Surgical stabilization of rib fractures was performed at a median of 5 days (P 25 -P 75 , 3-8 days) after CPR. In the nonoperative group, a rib fixation specialist was consulted in 14 patients (21%). The ICU LOS was longer in the SSRF group (13 days [P 25 -P 75 , 9-23 days] vs. 9 days [P 25 -P 75 , 5-15 days]; p = 0.004). Mechanical ventilator-free days, hospital LOS, thoracic complications, and mortality were similar. CONCLUSION: Despite matching, those who underwent SSRF over nonoperative management for multiple rib fractures following CPR had more severe consequential chest wall injury and a longer ICU LOS. A benefit of SSRF on in-hospital outcomes could not be demonstrated. A low consultation rate for rib fixation in the nonoperative group indicates that the consideration to perform SSRF in this population might be associated with other nonradiographic or injury-related variables. LEVEL OF EVIDENCE: Therapeutic/Care Management; Level III.
- Published
- 2022
30. Aortic balloon occlusion (REBOA) in pelvic ring injuries: preliminary results of the ABO Trauma Registry
- Author
-
Adam Bersztel, Camilla Cremonini, Endre Szarka, Fausto Catena, Maria Grazia Sibilla, Artai Pirouzram, Enrico Cicuttin, Eva-Corina Caragounis, Boris Kessel, Federico Coccolini, Yosuke Matsumura, Lauri Handolin, Viktor A. Reva, Emiliano Gamberini, Per Skoog, Sung Wook Chang, George Oosthuizen, David T. McGreevy, Miklosh Bala, Kristofer F. Nilsson, Yuri Kon, Luca Ansaloni, Vanni Agnoletti, Mariusz Maszkowski, Tongporn Wannatoop, Matteo Tomasoni, Marco Ceresoli, V Manchev, Tokiya Ishida, Mårten Falkenberg, Gad Shaked, Mitra Sadeghi, Massimo Chiarugi, Carlos A. Ordoñez, Paola Fugazzola, Junichi Matsumoto, Peter Hibert-Carius, Thomas Larzon, Dan Hebron, Claudia Zaghi, Koji Idoguchi, Asko Toivola, Tal M. Hörer, Coccolini, F, Ceresoli, M, Mcgreevy, D, Sadeghi, M, Pirouzram, A, Toivola, A, Skoog, P, Idoguchi, K, Kon, Y, Ishida, T, Matsumura, Y, Matsumoto, J, Reva, V, Maszkowski, M, Fugazzola, P, Tomasoni, M, Cicuttin, E, Ansaloni, L, Zaghi, C, Sibilla, M, Cremonini, C, Bersztel, A, Caragounis, E, Falkenberg, M, Handolin, L, Oosthuizen, G, Szarka, E, Manchev, V, Wannatoop, T, Chang, S, Kessel, B, Hebron, D, Shaked, G, Bala, M, Ordonez, C, Hibert-Carius, P, Chiarugi, M, Nilsson, K, Larzon, T, Gamberini, E, Agnoletti, V, Catena, F, and Horer, T
- Subjects
Male ,Hemodynamics ,0302 clinical medicine ,Registries ,Aorta ,Univariate analysis ,education.field_of_study ,Trauma Severity Indices ,ABO ,EVTM ,Hemodynamic ,International ,Morbidity ,Mortality ,Pelvis ,REBOA ,Registry ,Trauma ,Mortality rate ,Hydrogen-Ion Concentration ,Middle Aged ,medicine.anatomical_structure ,Blunt trauma ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Adult ,medicine.medical_specialty ,Adolescent ,Systole ,Pelvi ,Population ,Arterial Occlusive Diseases ,Shock, Hemorrhagic ,Young Adult ,03 medical and health sciences ,medicine.artery ,medicine ,Humans ,International Normalized Ratio ,education ,business.industry ,Balloon Occlusion ,Surgery ,Blood pressure ,business - Abstract
EndoVascular and Hybrid Trauma Management (EVTM) has been recently introduced in the treatment of severe pelvic ring injuries. This multimodal method of hemorrhage management counts on several strategies such as the REBOA (resuscitative endovascular balloon occlusion of the aorta). Few data exist on the use of REBOA in patients with a severely injured pelvic ring. The ABO (aortic balloon occlusion) Trauma Registry is designed to capture data for all trauma patients in hemorrhagic shock where management includes REBOA placement. Among all patients included in the ABO registry, 72 patients presented with severe pelvic injuries and were the population under exam. 66.7% were male. Mean and median ISS were respectively 43 and 41 (SD ± 13). Isolated pelvic injuries were observed in 12 patients (16.7%). Blunt trauma occurred in 68 patients (94.4%), penetrating in 2 (2.8%) and combined in 2 (2.8%). Type of injury: fall from height in 15 patients (23.1%), traffic accident in 49 patients (75.4%), and unspecified impact in 1 patient (1.5%). Femoral access was gained pre-hospital in 1 patient, in emergency room in 43, in operating room in 12 and in angio-suite in 16. REBOA was positioned in zone 1 in 59 patients (81,9%), in zone 2 in 1 (1,4%) and in zone 3 in 12 (16,7%). Aortic occlusion was partial/periodical in 35 patients (48,6%) and total occlusion in 37 patients (51,4%). REBOA associated morbidity rate: 11.1%. Overall mortality rate was 54.2% and early mortality rate (≤ 24 h) was 44.4%. In the univariate analysis, factors related to early mortality (≤ 24 h) are lower pH values (p = 0.03), higher base deficit (p = 0.021), longer INR (p = 0.012), minor increase in systolic blood pressure after the REBOA inflation (p = 0.03) and total aortic occlusion (p = 0.008). None of these values resulted significant in the multivariate analysis. In severe hemodynamically unstable pelvic trauma management, REBOA is a viable option when utilized in experienced centers as a bridge to other treatments; its use might be, however, accompanied with severe-to-lethal complications.
- Published
- 2020
31. Epidemiology of firearm injuries in Sweden
- Author
-
Pauline Djerf, Karolina Nyberger, Carl-Magnus Wahlgren, and Eva-Corina Caragounis
- Subjects
Adult ,Male ,Firearms ,medicine.medical_specialty ,Sports medicine ,Population ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,education ,Retrospective Studies ,Sweden ,education.field_of_study ,Abbreviated Injury Scale ,business.industry ,030208 emergency & critical care medicine ,Emergency department ,medicine.disease ,Hospitalization ,medicine.anatomical_structure ,Emergency medicine ,Emergency Medicine ,Abdomen ,Female ,Wounds, Gunshot ,Surgery ,Body region ,Gunshot wound ,business - Abstract
Background Gun violence is a global health problem. Population-based research on firearm-related injuries has been relatively limited considering the burden of disease. The aim of this study was to analyze nationwide epidemiological trends of firearm injuries. Methods This is a retrospective nationwide epidemiological study including all patients with firearm injuries from the Swedish Trauma Registry (SweTrau) during the period 2011 and 2019. Registry data were merged with data from the Swedish National Council for Crime Prevention and the Swedish Police Authority. Results There were 1010 patients admitted with firearm injuries, 96.6% men and 3.4% women, median age 26.0 years [IQR 22.0–36.3]. The overall number of firearm injuries increased on a yearly basis (P Conclusions This nationwide study shows an annual increase of firearm-related injuries and fatalities. Firearm injuries affect people of all ages but more frequently young males in major cities. One in six patients succumbed from their injuries within 30 days with most deaths occurring within 24 h of hospital admission. Given the impact of firearm-related injuries on society additional research on a national level is critical.
- Published
- 2021
32. Surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures following cardiopulmonary resuscitation: An international, retrospective matched case-control study
- Author
-
Prins, Jonne T.H., primary, Van Lieshout, Esther M.M., additional, Eriksson, Evert A., additional, Barnes, Matthew, additional, Blokhuis, Taco J., additional, Caragounis, Eva-Corina, additional, Christie, D. Benjamin, additional, De Loos, Erik R., additional, DeVoe, William B., additional, Formijne Jonkers, Henk A., additional, Kiel, Brandon, additional, Ko, Huan-Jang, additional, Marasco, Silvana F., additional, Spanjersberg, Willem R., additional, Su, Ying-Hao, additional, Summerhayes, Robyn G., additional, Van Huijstee, Pieter J., additional, Vermeulen, Jefrey, additional, Vos, Dagmar I., additional, Verhofstad, Michael H.J., additional, and Wijffels, Mathieu M.E., additional
- Published
- 2022
- Full Text
- View/download PDF
33. Aortic balloon occlusion (REBOA) in pelvic ring injuries: preliminary results of the ABO Trauma Registry
- Author
-
Coccolini, F, Ceresoli, M, Mcgreevy, D, Sadeghi, M, Pirouzram, A, Toivola, A, Skoog, P, Idoguchi, K, Kon, Y, Ishida, T, Matsumura, Y, Matsumoto, J, Reva, V, Maszkowski, M, Fugazzola, P, Tomasoni, M, Cicuttin, E, Ansaloni, L, Zaghi, C, Sibilla, M, Cremonini, C, Bersztel, A, Caragounis, E, Falkenberg, M, Handolin, L, Oosthuizen, G, Szarka, E, Manchev, V, Wannatoop, T, Chang, S, Kessel, B, Hebron, D, Shaked, G, Bala, M, Ordonez, C, Hibert-Carius, P, Chiarugi, M, Nilsson, K, Larzon, T, Gamberini, E, Agnoletti, V, Catena, F, Horer, T, Coccolini F., Ceresoli M., McGreevy D. T., Sadeghi M., Pirouzram A., Toivola A., Skoog P., Idoguchi K., Kon Y., Ishida T., Matsumura Y., Matsumoto J., Reva V., Maszkowski M., Fugazzola P., Tomasoni M., Cicuttin E., Ansaloni L., Zaghi C., Sibilla M. G., Cremonini C., Bersztel A., Caragounis E. -C., Falkenberg M., Handolin L., Oosthuizen G., Szarka E., Manchev V., Wannatoop T., Chang S. W., Kessel B., Hebron D., Shaked G., Bala M., Ordonez C. A., Hibert-Carius P., Chiarugi M., Nilsson K. F., Larzon T., Gamberini E., Agnoletti V., Catena F., Horer T. M., Coccolini, F, Ceresoli, M, Mcgreevy, D, Sadeghi, M, Pirouzram, A, Toivola, A, Skoog, P, Idoguchi, K, Kon, Y, Ishida, T, Matsumura, Y, Matsumoto, J, Reva, V, Maszkowski, M, Fugazzola, P, Tomasoni, M, Cicuttin, E, Ansaloni, L, Zaghi, C, Sibilla, M, Cremonini, C, Bersztel, A, Caragounis, E, Falkenberg, M, Handolin, L, Oosthuizen, G, Szarka, E, Manchev, V, Wannatoop, T, Chang, S, Kessel, B, Hebron, D, Shaked, G, Bala, M, Ordonez, C, Hibert-Carius, P, Chiarugi, M, Nilsson, K, Larzon, T, Gamberini, E, Agnoletti, V, Catena, F, Horer, T, Coccolini F., Ceresoli M., McGreevy D. T., Sadeghi M., Pirouzram A., Toivola A., Skoog P., Idoguchi K., Kon Y., Ishida T., Matsumura Y., Matsumoto J., Reva V., Maszkowski M., Fugazzola P., Tomasoni M., Cicuttin E., Ansaloni L., Zaghi C., Sibilla M. G., Cremonini C., Bersztel A., Caragounis E. -C., Falkenberg M., Handolin L., Oosthuizen G., Szarka E., Manchev V., Wannatoop T., Chang S. W., Kessel B., Hebron D., Shaked G., Bala M., Ordonez C. A., Hibert-Carius P., Chiarugi M., Nilsson K. F., Larzon T., Gamberini E., Agnoletti V., Catena F., and Horer T. M.
- Abstract
EndoVascular and Hybrid Trauma Management (EVTM) has been recently introduced in the treatment of severe pelvic ring injuries. This multimodal method of hemorrhage management counts on several strategies such as the REBOA (resuscitative endovascular balloon occlusion of the aorta). Few data exist on the use of REBOA in patients with a severely injured pelvic ring. The ABO (aortic balloon occlusion) Trauma Registry is designed to capture data for all trauma patients in hemorrhagic shock where management includes REBOA placement. Among all patients included in the ABO registry, 72 patients presented with severe pelvic injuries and were the population under exam. 66.7% were male. Mean and median ISS were respectively 43 and 41 (SD ± 13). Isolated pelvic injuries were observed in 12 patients (16.7%). Blunt trauma occurred in 68 patients (94.4%), penetrating in 2 (2.8%) and combined in 2 (2.8%). Type of injury: fall from height in 15 patients (23.1%), traffic accident in 49 patients (75.4%), and unspecified impact in 1 patient (1.5%). Femoral access was gained pre-hospital in 1 patient, in emergency room in 43, in operating room in 12 and in angio-suite in 16. REBOA was positioned in zone 1 in 59 patients (81,9%), in zone 2 in 1 (1,4%) and in zone 3 in 12 (16,7%). Aortic occlusion was partial/periodical in 35 patients (48,6%) and total occlusion in 37 patients (51,4%). REBOA associated morbidity rate: 11.1%. Overall mortality rate was 54.2% and early mortality rate (≤ 24 h) was 44.4%. In the univariate analysis, factors related to early mortality (≤ 24 h) are lower pH values (p = 0.03), higher base deficit (p = 0.021), longer INR (p = 0.012), minor increase in systolic blood pressure after the REBOA inflation (p = 0.03) and total aortic occlusion (p = 0.008). None of these values resulted significant in the multivariate analysis. In severe hemodynamically unstable pelvic trauma management, REBOA is a viable option when utilized in experienced centers as a bridge to other
- Published
- 2020
34. Surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures following cardiopulmonary resuscitation:An international, retrospective matched case-control study
- Author
-
Prins, Jonne T.H., Van Lieshout, Esther M.M., Eriksson, Evert A., Barnes, Matthew, Blokhuis, Taco J., Caragounis, Eva Corina, Christie, D. Benjamin, De Loos, Erik R., DeVoe, William B., Formijne Jonkers, Henk A., Kiel, Brandon, Ko, Huan Jang, Marasco, Silvana F., Spanjersberg, Willem R., Su, Ying Hao, Summerhayes, Robyn G., Van Huijstee, Pieter J., Vermeulen, Jefrey, Vos, Dagmar I., Verhofstad, Michael H.J., Wijffels, Mathieu M.E., Prins, Jonne T.H., Van Lieshout, Esther M.M., Eriksson, Evert A., Barnes, Matthew, Blokhuis, Taco J., Caragounis, Eva Corina, Christie, D. Benjamin, De Loos, Erik R., DeVoe, William B., Formijne Jonkers, Henk A., Kiel, Brandon, Ko, Huan Jang, Marasco, Silvana F., Spanjersberg, Willem R., Su, Ying Hao, Summerhayes, Robyn G., Van Huijstee, Pieter J., Vermeulen, Jefrey, Vos, Dagmar I., Verhofstad, Michael H.J., and Wijffels, Mathieu M.E.
- Abstract
BACKGROUND: The presence of six or more rib fractures or a displaced rib fracture due to cardiopulmonary resuscitation (CPR) has been associated with longer hospital and intensive care unit (ICU) length of stay (LOS). Evidence on the effect of surgical stabilization of rib fractures (SSRF) following CPR is limited. This study aimed to evaluate outcomes after SSRF versus nonoperative management in patients with multiple rib fractures after CPR. METHODS: An international, retrospective study was performed in patients who underwent SSRF or nonoperative management for multiple rib fractures following CPR between January 1, 2012, and July 31, 2020. Patients who underwent SSRF were matched to nonoperative controls by cardiac arrest location and cause, rib fracture pattern, and age. The primary outcome was ICU LOS. RESULTS: Thirty-nine operatively treated patient were matched to 66 nonoperatively managed controls with comparable CPR-related characteristics. Patients who underwent SSRF more often had displaced rib fractures (n = 28 [72%] vs. n = 31 [47%]; p = 0.015) and a higher median number of displaced ribs (2 [P 25 -P 75 , 0-3] vs. 0 [P 25 -P 75 , 0-3]; p = 0.014). Surgical stabilization of rib fractures was performed at a median of 5 days (P 25 -P 75 , 3-8 days) after CPR. In the nonoperative group, a rib fixation specialist was consulted in 14 patients (21%). The ICU LOS was longer in the SSRF group (13 days [P 25 -P 75 , 9-23 days] vs. 9 days [P 25 -P 75 , 5-15 days]; p = 0.004). Mechanical ventilator-free days, hospital LOS, thoracic complications, and mortality were similar. CONCLUSION: Despite matching, those who underwent SSRF over nonoperative management for multiple rib fractures following CPR had more severe consequential chest wall injury and a longer ICU LOS. A benefit of SSRF on in-hospital outcomes could not be demonstrated. A low consultation rate for rib fixation in the nonoperative group indicates that the consideration to perform SSRF in this popula
- Published
- 2022
35. Surgical stabilization versus nonoperative treatment for flail and non-flail rib fracture patterns in patients with traumatic brain injury
- Author
-
Prins, Jonne T.H., Van Lieshout, Esther M.M., Ali-Osman, Francis, Bauman, Zachary M., Caragounis, Eva Corina, Choi, Jeff, Christie, D. Benjamin, Cole, Peter A., DeVoe, William B., Doben, Andrew R., Eriksson, Evert A., Forrester, Joseph D., Fraser, Douglas R., Gontarz, Brendan, Hardman, Claire, Hyatt, Daniel G., Kaye, Adam J., Ko, Huan Jang, Leasia, Kiara N., Leon, Stuart, Marasco, Silvana F., McNickle, Allison G., Nowack, Timothy, Ogunleye, Temi D., Priya, Prakash, Richman, Aaron P., Schlanser, Victoria, Semon, Gregory R., Su, Ying Hao, Verhofstad, Michael H.J., Whitis, Julie, Pieracci, Fredric M., Wijffels, Mathieu M.E., Prins, Jonne T.H., Van Lieshout, Esther M.M., Ali-Osman, Francis, Bauman, Zachary M., Caragounis, Eva Corina, Choi, Jeff, Christie, D. Benjamin, Cole, Peter A., DeVoe, William B., Doben, Andrew R., Eriksson, Evert A., Forrester, Joseph D., Fraser, Douglas R., Gontarz, Brendan, Hardman, Claire, Hyatt, Daniel G., Kaye, Adam J., Ko, Huan Jang, Leasia, Kiara N., Leon, Stuart, Marasco, Silvana F., McNickle, Allison G., Nowack, Timothy, Ogunleye, Temi D., Priya, Prakash, Richman, Aaron P., Schlanser, Victoria, Semon, Gregory R., Su, Ying Hao, Verhofstad, Michael H.J., Whitis, Julie, Pieracci, Fredric M., and Wijffels, Mathieu M.E.
- Abstract
Purpose: Literature on outcomes after SSRF, stratified for rib fracture pattern is scarce in patients with moderate to severe traumatic brain injury (TBI; Glasgow Coma Scale ≤ 12). We hypothesized that SSRF is associated with improved outcomes as compared to nonoperative management without hampering neurological recovery in these patients. Methods: A post hoc subgroup analysis of the multicenter, retrospective CWIS-TBI study was performed in patients with TBI and stratified by having sustained a non-flail fracture pattern or flail chest between January 1, 2012 and July 31, 2019. The primary outcome was mechanical ventilation-free days and secondary outcomes were in-hospital outcomes. In multivariable analysis, outcomes were assessed, stratified for rib fracture pattern. Results: In total, 449 patients were analyzed. In patients with a non-flail fracture pattern, 25 of 228 (11.0%) underwent SSRF and in patients with a flail chest, 86 of 221 (38.9%). In multivariable analysis, ventilator-free days were similar in both treatment groups. For patients with a non-flail fracture pattern, the odds of pneumonia were significantly lower after SSRF (odds ratio 0.29; 95% CI 0.11–0.77; p = 0.013). In patients with a flail chest, the ICU LOS was significantly shorter in the SSRF group (beta, − 2.96 days; 95% CI − 5.70 to − 0.23; p = 0.034). Conclusion: In patients with TBI and a non-flail fracture pattern, SSRF was associated with a reduced pneumonia risk. In patients with TBI and a flail chest, a shorter ICU LOS was observed in the SSRF group. In both groups, SSRF was safe and did not hamper neurological recovery.
- Published
- 2022
36. Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis
- Author
-
Katja M. Kanninen, Alexandra Grubman, Aphrodite Caragounis, Clare Duncan, Sarah J. Parker, Grace E. Lidgerwood, Irene Volitakis, George Ganio, Peter J. Crouch, and Anthony R. White
- Subjects
Neurodegeneration ,Biometal homeostasis ,Neuronal ceroid lipofuscinoses ,CLN6 ,Metal transporter ,Science ,Biology (General) ,QH301-705.5 - Abstract
Summary Neuronal ceroid lipofuscinoses, the most common fatal childhood neurodegenerative illnesses, share many features with more prevalent neurodegenerative diseases. Neuronal ceroid lipofuscinoses are caused by mutations in CLN genes. CLN6 encodes a transmembrane endoplasmic reticulum protein with no known function. We characterized the behavioural phenotype of spontaneous mutant mice modeling CLN6 disease, and demonstrate progressive motor and visual decline and reduced lifespan in these mice, consistent with symptoms observed in neuronal ceroid lipofuscinosis patients. Alterations to biometal homeostasis are known to play a critical role in pathology in Alzheimer's, Parkinson's, Huntington's and motor neuron diseases. We have previously shown accumulation of the biometals, zinc, copper, manganese and cobalt, in CLN6 Merino and South Hampshire sheep at the age of symptom onset. Here we determine the physiological and disease-associated expression of CLN6, demonstrating regional CLN6 transcript loss, and concurrent accumulation of the same biometals in the CNS and the heart of presymptomatic CLN6 mice. Furthermore, increased expression of the ER/Golgi-localized cation transporter protein, Zip7, was detected in cerebellar Purkinje cells and whole brain fractions. Purkinje cells not only control motor function, an early symptomatic change in the CLN6 mice, but also display prominent neuropathological changes in mouse models and patients with different forms of neuronal ceroid lipofuscinoses. Whole brain fractionation analysis revealed biometal accumulation in fractions expressing markers for ER, Golgi, endosomes and lysosomes of CLN6 brains. These data are consistent with a link between CLN6 expression and biometal homeostasis in CLN6 disease, and provide further support for altered cation transporter regulation as a key factor in neurodegeneration.
- Published
- 2013
- Full Text
- View/download PDF
37. Outcome after surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures and moderate to severe traumatic brain injury (CWIS-TBI)
- Author
-
Mathieu M. E. Wijffels, Jeff Choi, Allison G. McNickle, Francis Ali-Osman, Kiara Leasia, William B. DeVoe, Claire Hardman, Eva Corina Caragounis, Aaron P. Richman, Stuart Leon, Prakash Priya, Brendan Gontarz, Temi D. Ogunleye, Silvana F. Marasco, Andrew R Doben, Adam J. Kaye, Fredric M. Pieracci, Esther M.M. Van Lieshout, Peter A. Cole, Gregory Semon, Joseph D. Forrester, D. Benjamin Christie, Zachary M. Bauman, Victoria Schlanser, Ying Hao Su, Evert A. Eriksson, Michael H.J. Verhofstad, Daniel G. Hyatt, Douglas R. Fraser, Timothy Nowack, Huan Jang Ko, Jonne T.H. Prins, Julie Whitis, and Surgery
- Subjects
Adult ,Male ,medicine.medical_specialty ,Critical Care ,Rib Fractures ,Fractures, Multiple ,Traumatic brain injury ,Critical Care and Intensive Care Medicine ,Lower risk ,law.invention ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Fracture Fixation ,law ,Brain Injuries, Traumatic ,Fracture fixation ,Odds Ratio ,medicine ,Humans ,Retrospective Studies ,business.industry ,030208 emergency & critical care medicine ,Retrospective cohort study ,Odds ratio ,Length of Stay ,Middle Aged ,medicine.disease ,Respiration, Artificial ,Intensive care unit ,Surgery ,Treatment Outcome ,Cohort ,Female ,Complication ,business - Abstract
BACKGROUND: Outcomes after surgical stabilization of rib fractures (SSRF) have not been studied in patients with multiple rib fractures and traumatic brain injury (TBI). We hypothesized that SSRF, as compared with nonoperative management, is associated with favorable outcomes in patients with TBI. METHODS: A multicenter, retrospective cohort study was performed in patients with rib fractures and TBI between January 2012 and July 2019. Patients who underwent SSRF were compared to those managed nonoperatively. The primary outcome was mechanical ventilation-free days. Secondary outcomes were intensive care unit length of stay and hospital length of stay, tracheostomy, occurrence of complications, neurologic outcome, and mortality. Patients were further stratified into moderate (GCS score, 9-12) and severe (GCS score, ≤8) TBI. RESULTS: The study cohort consisted of 456 patients of which 111 (24.3%) underwent SSRF. The SSRF was performed at a median of 3 days, and SSRF-related complication rate was 3.6%. In multivariable analyses, there was no difference in mechanical ventilation-free days between the SSRF and nonoperative groups. The odds of developing pneumonia (odds ratio [OR], 0.59; 95% confidence interval [95% CI], 0.38-0.98; p = 0.043) and 30-day mortality (OR, 0.32; 95% CI, 0.11-0.91; p = 0.032) were significantly lower in the SSRF group. Patients with moderate TBI had similar outcome in both groups. In patients with severe TBI, the odds of 30-day mortality was significantly lower after SSRF (OR, 0.19; 95% CI, 0.04-0.88; p = 0.034). CONCLUSION: In patients with multiple rib fractures and TBI, the mechanical ventilation-free days did not differ between the two treatment groups. In addition, SSRF was associated with a significantly lower risk of pneumonia and 30-day mortality. In patients with moderate TBI, outcome was similar. In patients with severe TBI a lower 30-day mortality was observed. There was a low SSRF-related complication risk. These data suggest a potential role for SSRF in select patients with TBI. LEVEL OF EVIDENCE: Therapeutic, level IV.
- Published
- 2020
38. Mortality of trauma patients treated at trauma centers compared to non-trauma centers in Sweden: a retrospective study
- Author
-
Eva-Corina Caragounis, Stefan Candefjord, and Linn Asker
- Subjects
medicine.medical_specialty ,Poison control ,Critical Care and Intensive Care Medicine ,Occupational safety and health ,03 medical and health sciences ,Injury Severity Score ,0302 clinical medicine ,Trauma Centers ,Injury prevention ,Odds Ratio ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Retrospective Studies ,Sweden ,business.industry ,Mortality rate ,Trauma center ,030208 emergency & critical care medicine ,Retrospective cohort study ,Odds ratio ,Emergency medicine ,Emergency Medicine ,Wounds and Injuries ,Surgery ,Triage ,business - Abstract
Objective The main objective was to compare the 30-day mortality rate of trauma patients treated at trauma centers as compared to non-trauma centers in Sweden. The secondary objective was to evaluate how injury severity influences the potential survival benefit of specialized care. Methods This retrospective study included 29,864 patients from the national Swedish Trauma Registry (SweTrau) during the period 2013–2017. Three sampling exclusion criteria were applied: (1) Injury Severity Score (ISS) of zero; (2) missing data in any variable of interest; (3) data falling outside realistic values and duplicate registrations. University hospitals were classified as trauma centers; other hospitals as non-trauma centers. Logistic regression was used to analyze the effect of trauma center care on mortality rate, while adjusting for other factors potentially affecting the risk of death. Results Treatment at a trauma center in Sweden was associated with a 41% lower adjusted 30-day mortality (odds ratio 0.59 [0.50–0.70], p 70% mortality decrease for the most critically injured group (ISS ≥ 50). Conclusions There exists a potentially substantial survival benefit for trauma patients treated at trauma centers in Sweden, especially for the most severely injured. This study motivates a critical review and possible reorganization of the national trauma system, and further research to identify the characteristics of patients in most need of specialized care.
- Published
- 2020
39. New Testament Investigations
- Author
-
Chrys C. Caragounis
- Published
- 2022
40. Increasing Cu Bioavailability Inhibits Aβ Oligomers and Tau Phosphorylation
- Author
-
Crouch, Peter J., Hung, Lin Wai, Adlard, Paul A., Cortes, Mikhalina, Lal, Varsha, Filiz, Gulay, Perez, Keyla A., Nurjono, Milawaty, Caragounis, Aphrodite, Du, Tai, Laughton, Katrina, Volitakis, Irene, Bush, Ashley I., Li, Qiao-Xin, Masters, Colin L., Cappai, Roberto, Cherny, Robert A., Donnelly, Paul S., White, Anthony R., and Barnham, Kevin J.
- Published
- 2009
- Full Text
- View/download PDF
41. What Did Jesus Mean by τὴν ἀρχήν in John 8:25?
- Author
-
Caragounis, Chrys C.
- Published
- 2007
- Full Text
- View/download PDF
42. Antigenic Differences and Conservation among Placental Plasmodium falciparum-Infected Erythrocytes and Acquisition of Variant-Specific and Cross-Reactive Antibodies
- Author
-
Beeson, James G., Mann, Emily J., Byrne, Timothy J., Caragounis, Aphrodite, Elliott, Salenna R., Brown, Graham V., and Rogerson, Stephen J.
- Published
- 2006
43. Peter and the Rock
- Author
-
Chrys C. Caragounis
- Published
- 2010
44. Zinc induces depletion and aggregation of endogenous TDP-43
- Author
-
Caragounis, Aphrodite, Price, Katherine Ann, Soon, Cynthia P.W., Filiz, Gulay, Masters, Colin L., Li, Qiao-Xin, Crouch, Peter J., and White, Anthony R.
- Published
- 2010
- Full Text
- View/download PDF
45. Mechanism of injury, injury patterns and associated injuries in patients operated for chest wall trauma
- Author
-
Eva-Corina Caragounis, Hans Granhed, and Yao Xiao
- Subjects
Flail chest ,medicine.medical_specialty ,Rib Fractures ,Thoracic Injuries ,Sports medicine ,medicine.medical_treatment ,Diaphragmatic breathing ,Wounds, Nonpenetrating ,Critical Care and Intensive Care Medicine ,030218 nuclear medicine & medical imaging ,Mechanism of injury ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Thoracotomy ,Thoracic Wall ,Operation ,Rib fracture ,Retrospective Studies ,Rib cage ,business.industry ,030208 emergency & critical care medicine ,medicine.disease ,Chest wall trauma ,Surgery ,Blunt trauma ,Emergency Medicine ,Injury Severity Score ,Original Article ,Body region ,Injury patterns ,business - Abstract
Purpose Chest wall injuries are common in blunt trauma and associated with significant morbidity and mortality. The aim of this study was to determine the most common mechanisms of injury (MOI), injury patterns, and associated injuries in patients who undergo surgery for chest wall trauma. Methods This was a retrospective study of trauma patients with multiple rib fractures and unstable thoracic cage injuries who were managed surgically at Sahlgrenska University Hospital during the period September 2010–September 2017. The MOI, injury severity score (ISS), new injury severity score (NISS), thoracic and associated injuries were recorded. Patients were categorized according to age (years): groups I (15‒44), II (45‒64) and III ( > 64). Unstable thoracic cage injuries were classified as sternal, anterior, lateral and posterior flail chest. Results Two hundred and eleven trauma patients with a mean age (years) of 58.2 ± 15.6, mean ISS 23.6 ± 11.0, and mean NISS 34.1 ± 10.6 were included in the study. Traffic accidents were the most common MOI in Group I (62%) and falls in Group III (59%). The most common flail segments were lateral and posterior. Sternal and anterior flail segments were more common with bilateral injuries and traffic accidents, particularly frontal collisions. Injuries in at least three body regions were also more associated with traffic accidents. Diaphragmatic injury was seen in 18% of patients who underwent thoracotomy. Conclusions The MOI associated with multiple rib fractures differs according to the age of the patient and is associated with different chest wall injury patterns and extra-thoracic injuries.
- Published
- 2019
46. CT-lung volume estimates in trauma patients undergoing stabilizing surgery for flail chest
- Author
-
Rauni Rossi Norrlund, Monika Fagevik Olsén, Hans Granhed, and Eva-Corina Caragounis
- Subjects
Adult ,Male ,Thorax ,medicine.medical_specialty ,Flail chest ,Vital capacity ,Rib Fractures ,Thoracic Injuries ,Pulmonary function testing ,Fracture Fixation, Internal ,Young Adult ,03 medical and health sciences ,FEV1/FVC ratio ,Injury Severity Score ,0302 clinical medicine ,Forced Expiratory Volume ,Preoperative Care ,Flail Chest ,medicine ,Humans ,Lung volumes ,Aged ,General Environmental Science ,Aged, 80 and over ,Postoperative Care ,030222 orthopedics ,Lung ,business.industry ,Total Lung Capacity ,030208 emergency & critical care medicine ,Cone-Beam Computed Tomography ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,Surgery ,Cross-Sectional Studies ,Treatment Outcome ,medicine.anatomical_structure ,Respiratory Mechanics ,General Earth and Planetary Sciences ,Female ,business ,Follow-Up Studies - Abstract
To estimate and compare lung volumes from pre- and post-operative computed tomography (CT) images and correlate findings with post-operative lung function tests in trauma patients with flail chest undergoing stabilizing surgery.Pre- and post-operative CT images of the thorax were used to estimate lung volumes in 37 patients who had undergone rib plate fixation at least 6 months before inclusion for flail chest due to blunt thoracic trauma. Computed tomography lung volumes were estimated from airway distal to each lung hilum by outlining air-filled lung tissue either manually in images of 5 mm slice thickness or automatically in images of 0.6 mm slice thickness. Demographics, pain, range of motion in the thorax, breathing movements and Forced Vital Capacity (FVC) were assessed. Total Lung Capacity (TLC) measurements were also made in a subgroup of patients (n = 17) who had not been intubated at time of the initial CT. Post-operative CT lung volumes were correlated to FVC and TLC.Patients with a median age of 62 (19-90) years, a median Injury Severity Score (ISS) of 20 (9-54), and a median New Injury Severity Score (NISS) of 27 (17-66) were enrolled in the study. Median follow-up time was 3.9 (0.5-5.6) years. Two patients complained of pain at rest and when breathing. Pre-operative CT lung volumes were significantly different (p 0.0001) from post-operative CT lung volumes, 3.51 l (1.50-6.05) vs. 5.59 l (2.18-7.78), respectively. At follow-up, median FVC was 3.76 l (1.48-5.84) and median TLC was 6.93 l (4.21-8.42). Post-operative CT lung volumes correlated highly with both FVC [rPost-operative CT-lung volume estimates improve compared to pre-operative values in trauma patients undergoing stabilizing surgery for flail chest, and can be used as a marker for lung function when deciding which patient with chest wall injuries can benefit from surgery.
- Published
- 2019
47. Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43
- Author
-
Moujalled, Diane, James, Janine L., Yang, Shu, Zhang, Katharine, Duncan, Clare, Moujalled, Donia M., Parker, Sarah J., Caragounis, Aphrodite, Lidgerwood, Grace, Turner, Bradley J., Atkin, Julie D., Grubman, Alexandra, Liddell, Jeffrey R., Proepper, Christian, Boeckers, Tobias M., Kanninen, Katja M., Blair, Ian, Crouch, Peter J., and White, Anthony R.
- Published
- 2015
- Full Text
- View/download PDF
48. Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.
- Author
-
Laura Bica, Jeffrey R Liddell, Paul S Donnelly, Clare Duncan, Aphrodite Caragounis, Irene Volitakis, Brett M Paterson, Roberto Cappai, Alexandra Grubman, James Camakaris, Peter J Crouch, and Anthony R White
- Subjects
Medicine ,Science - Abstract
Abnormal biometal homeostasis is a central feature of many neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and motor neuron disease. Recent studies have shown that metal complexing compounds behaving as ionophores such as clioquinol and PBT2 have robust therapeutic activity in animal models of neurodegenerative disease; however, the mechanism of neuroprotective action remains unclear. These neuroprotective or neurogenerative processes may be related to the delivery or redistribution of biometals, such as copper and zinc, by metal ionophores. To investigate this further, we examined the effect of the bis(thiosemicarbazonato)-copper complex, Cu(II)(gtsm) on neuritogenesis and neurite elongation (neurogenerative outcomes) in PC12 neuronal-related cultures. We found that Cu(II)(gtsm) induced robust neurite elongation in PC12 cells when delivered at concentrations of 25 or 50 nM overnight. Analogous effects were observed with an alternative copper bis(thiosemicarbazonato) complex, Cu(II)(atsm), but at a higher concentration. Induction of neurite elongation by Cu(II)(gtsm) was restricted to neurites within the length range of 75-99 µm with a 2.3-fold increase in numbers of neurites in this length range with 50 nM Cu(II)(gtsm) treatment. The mechanism of neurogenerative action was investigated and revealed that Cu(II)(gtsm) inhibited cellular phosphatase activity. Treatment of cultures with 5 nM FK506 (calcineurin phosphatase inhibitor) resulted in analogous elongation of neurites compared to 50 nM Cu(II)(gtsm), suggesting a potential link between Cu(II)(gtsm)-mediated phosphatase inhibition and neurogenerative outcomes.
- Published
- 2014
- Full Text
- View/download PDF
49. ΟΨΩΝΙΟΝ: A Reconsideration of Its Meaning
- Author
-
Caragounis, Chrys C.
- Published
- 1974
- Full Text
- View/download PDF
50. Blue rubber bleb naevus syndrome: A rare cause of gastrointestinal bleeding in an African child
- Author
-
Walter C, Mbebe T, Caragounis E, and Thirsk I
- Subjects
Blue rubber bleb naevus syndrome ,gastrointestinal bleeding ,on-table colonoscopy ,surgery ,vascular malformation ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Blue rubber bleb naevus syndrome (BRBNS) is characterised by vascular malformations of the skin and gastrointestinal tract. We present the rare case of BRBNS in an African child. She presented with large-volume gastrointestinal bleeding and was managed by on-table colonoscopic identification and surgical excision, of all her enteric, vascular malformations.
- Published
- 2010
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.