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2. Telemedicine for Individuals with epilepsy: Recommendations from the International League Against Epilepsy Telemedicine Task Force

Author

Samia, Pauline, Sahu, Jitendra Kumar, Ali, Amza, Caraballo, Roberto Horacio, Chan, Josephine, Coan, Ana Carolina, Fortini, Pablo Sebastián, Gwer, Samson, Jocic-Jakubi, Bosanka, Kissani, Najib, Rivera, Yanin, Sarfo, Fred Stephen, Singh, Mamta Bhushan, Trinka, Eugen, Yoo, Ji Yeoun, Yu, Hsiang-Yu, Zelano, Johan, and Cross, J.Helen

Published
2023
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5. Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study

Author

Projectafdeling FNE, Cerulli Irelli, Emanuele, Cocchi, Enrico, Ramantani, Georgia, Riva, Antonella, Caraballo, Roberto Horacio, Morano, Alessandra, Giuliano, Loretta, Yilmaz, Tülay, Panagiotakaki, Eleni, Operto, Francesca F., Giraldez, Beatriz Gonzalez, Balestrini, Simona, Silvennoinen, Katri, Casciato, Sara, Comajuan, Marion, Fortunato, Francesco, Giallonardo, Anna Teresa, Gamirova, Rimma, Coppola, Antonietta, Di Gennaro, Giancarlo, Labate, Angelo, Sofia, Vito, Kluger, Gerhard Josef, Gambardella, Antonio, Kasteleijn-NolstTrenite, Dorothee G.A., Baykan, Betul, Sisodiya, Sanjay M., Arzimanoglou, Alexis, Striano, Pasquale, Di Bonaventura, Carlo, the EMA Study Group, Projectafdeling FNE, Cerulli Irelli, Emanuele, Cocchi, Enrico, Ramantani, Georgia, Riva, Antonella, Caraballo, Roberto Horacio, Morano, Alessandra, Giuliano, Loretta, Yilmaz, Tülay, Panagiotakaki, Eleni, Operto, Francesca F., Giraldez, Beatriz Gonzalez, Balestrini, Simona, Silvennoinen, Katri, Casciato, Sara, Comajuan, Marion, Fortunato, Francesco, Giallonardo, Anna Teresa, Gamirova, Rimma, Coppola, Antonietta, Di Gennaro, Giancarlo, Labate, Angelo, Sofia, Vito, Kluger, Gerhard Josef, Gambardella, Antonio, Kasteleijn-NolstTrenite, Dorothee G.A., Baykan, Betul, Sisodiya, Sanjay M., Arzimanoglou, Alexis, Striano, Pasquale, Di Bonaventura, Carlo, and the EMA Study Group

Published
2023

17. Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study.

Author

Cerulli Irelli, Emanuele, Cocchi, Enrico, Ramantani, Georgia, Riva, Antonella, Caraballo, Roberto Horacio, Morano, Alessandra, Giuliano, Loretta, Yilmaz, Tülay, Panagiotakaki, Eleni, Operto, Francesca F., Giraldez, Beatriz Gonzalez, Balestrini, Simona, Silvennoinen, Katri, Casciato, Sara, Comajuan, Marion, Fortunato, Francesco, Giallonardo, Anna Teresa, Gamirova, Rimma, Coppola, Antonietta, and Di Gennaro, Giancarlo

Subjects
EPILEPSY, PROBABILITY density function, EYELIDS, SEIZURES (Medicine), MIGRAINE aura, AGE of onset
Abstract

Objective: Epilepsy with eyelid myoclonia (EEM) has been associated with marked clinical heterogeneity. Early epilepsy onset has been recently linked to lower chances of achieving sustained remission and to a less favorable neuropsychiatric outcome. However, much work is still needed to better delineate this epilepsy syndrome. Methods: In this multicenter retrospective cohort study, we included 267 EEM patients from nine countries. Data on electroclinical and demographic features, intellectual functioning, migraine with or without aura, family history of epilepsy, and epilepsy syndromes in relatives were collected in each patient. The impact of age at epilepsy onset (AEO) on EEM clinical features was investigated, along with the distinctive clinical characteristics of patients showing sporadic myoclonia involving body regions other than eyelids (body‐MYO). Results: Kernel density estimation revealed a trimodal distribution of AEO, and Fisher–Jenks optimization disclosed three EEM subgroups: early onset (EO‐EEM), intermediate onset (IO‐EEM), and late onset (LO‐EEM). EO‐EEM was associated with the highest rate of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities and with the lowest rate of family history of epilepsy. LO‐EEM was associated with the highest proportion of body‐MYO and generalized tonic–clonic seizures (GTCS), whereas IO‐EEM had the lowest observed rate of additional findings. A family history of EEM was significantly more frequent in IO‐EEM and LO‐EEM compared with EO‐EEM. In the subset of patients with body‐MYO (58/267), we observed a significantly higher rate of migraine and GTCS but no relevant differences in other electroclinical features and seizure outcome. Significance: Based on AEO, we identified consistent EEM subtypes characterized by distinct electroclinical and familial features. Our observations shed new light on the spectrum of clinical features of this generalized epilepsy syndrome and may help clinicians toward a more accurate classification and prognostic profiling of EEM patients. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Ictal blinking, an under-recognized phenomenon: our experience and literature review

Author

Saporito,Marco Andrea Nicola, Vitaliti,Giovanna, Pavone,Piero, Di Stefano,Giuseppa, Striano,Pasquale, Caraballo,Roberto Horacio, Falsaperla,Raffaele, Saporito,Marco Andrea Nicola, Vitaliti,Giovanna, Pavone,Piero, Di Stefano,Giuseppa, Striano,Pasquale, Caraballo,Roberto Horacio, and Falsaperla,Raffaele

Abstract

Marco Andrea Nicola Saporito,1 Giovanna Vitaliti,2 Piero Pavone,2 Giuseppa Di Stefano,1 Pasquale Striano,3 Roberto Horacio Caraballo,4 Raffaele Falsaperla2 1Neonatal Intensive Care Unit, Santo Bambino Hospital, Policlinico-Vittorio Emanuele University Hospital, University of Catania, Catania, Italy; 2Paediatric Operative Unit and Acute and Emergency, Policlinico-Vittorio Emanuele University Hospital, University of Catania, Catania, Italy; 3Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, Institute “G. Gaslini” University of Genova, Genoa, Italy; 4Department of Neurology, Hospital de Pediatría “Prof Dr Juan P Garrahan”, Buenos Aires, Argentina Abstract: Ictal blinking (IB) is a very rare disease manifesting as an epileptic motor event in children and adults. Until now it has not been included in any classification of focal seizures of the International League Against Epilepsy Commission. It could be unilateral or bilateral, isolated or in association with other motor manifestations such as limbs’ clonus and spasms. Its pathogenesis has not been clearly established: paroxysmal discharges from different areas of the brain could cause IB by activation of trigeminal fibers. Herein authors report three infants and a child with IB, observed in three pediatric centers in two different countries. We also performed a review of literature data, suggesting IB as a seizure type to be included in international classifications, and describing the specific electroencephalographic pattern of this condition. Keywords: ictal blinking, focal motor phenomenon, ictal electroencephalographic pattern, occipital area, infancy

Published
2017

36. Consenso nacional de dieta Atkins modificada

Author

Vaccarezza Ferrari, María, primary, Agustinho, Ariela, additional, Alberti, María Julia, additional, Argumedo, Laura, additional, Armeno, Marisa, additional, Blanco, Virginia, additional, Bouquet, Cecilia, additional, Cabrera, Analía, additional, Caraballo, Roberto Horacio, additional, Caramuta, Luciana, additional, Cresta, Araceli, additional, De Grandis, Elizabeth S., additional, Demartini, Martha Graciela, additional, Díez, Cecilia, additional, Diz, Mariana, additional, Dlugoszewski, Corina, additional, Escobal, Nidia, additional, Ferrero, Hilario, additional, Galicchio, Santiago, additional, Gambarini, Victoria, additional, Gamboni, Beatriz, additional, González, Lara, additional, Guisande, Silvina, additional, Hassan, Amal, additional, Matarrese, Pablo, additional, Mestre, Graciela, additional, Pesce, Laura, additional, Ríos, Viviana, additional, Semprino, Marcos, additional, Sosa, Patricia, additional, Toma, Marisol, additional, Viollaz, Rocío, additional, and Panico, Luis Ramón, additional

Published
2016
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37. Treatment of electrical status epilepticus in sleep: A pooled analysis of 575 cases

Author

Van Den Munckhof, Bart, Bulteau, Christine, Braun, Kees P J, Jansen, Floor F.E., Van Dee, Violet, Sagi, Liora, Caraballo, Roberto Horacio Oracio R.H., Veggiotti, Pierangelo, Liukkonen, Elina, Loddenkemper, Tobias, Fernández, Ivan Sánchez, Buzatu, Marga, Van Den Munckhof, Bart, Bulteau, Christine, Braun, Kees P J, Jansen, Floor F.E., Van Dee, Violet, Sagi, Liora, Caraballo, Roberto Horacio Oracio R.H., Veggiotti, Pierangelo, Liukkonen, Elina, Loddenkemper, Tobias, Fernández, Ivan Sánchez, and Buzatu, Marga

Abstract

Objective Epileptic encephalopathy with electrical status epilepticus in sleep (ESES) is a pediatric epilepsy syndrome with sleep-induced epileptic discharges and acquired impairment of cognition or behavior. Treatment of ESES is assumed to improve cognitive outcome. The aim of this study is to create an overview of the current evidence for different treatment regimens in children with ESES syndrome. Methods A literature search using PubMed and Embase was performed. Articles were selected that contain original treatment data of patients with ESES syndrome. Authors were contacted for additional information. Individual patient data were collected, coded, and analyzed using logistic regression analysis. The three predefined main outcome measures were improvement in cognitive function, electroencephalography (EEG) pattern, and any improvement (cognition or EEG). Results The literature search yielded 1,766 articles. After applying inclusion and exclusion criteria, 112 articles and 950 treatments in 575 patients could be analyzed. Antiepileptic drugs (AEDs, n = 495) were associated with improvement (i.e. cognition or EEG) in 49% of patients, benzodiazepines (n = 171) in 68%, and steroids (n = 166) in 81%. Surgery (n = 62) resulted in improvement in 90% of patients. In a subgroup analysis of patients who were consecutively reported (585 treatments in 282 patients), we found improvement in a smaller proportion treated with AEDs (34%), benzodiazepines (59%), and steroids (75%), whereas the improvement percentage after surgery was preserved (93%). Possible predictors of improved outcome were treatment category, normal development before ESES onset, and the absence of structural abnormalities. Significance Although most included studies were small and retrospective and their heterogeneity allowed analysis of only qualitative outcome data, this pooled analysis suggests superior efficacy of steroids and surgery in encephalopathy with ESES., SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published

Published
2015

41. Consenso nacional sobre dieta cetogénica

Author

Armeno, Marisa, primary, Caraballo, Roberto Horacio, additional, Vaccarezza Ferrari, María, additional, Alberti, María Julia, additional, Ríos, Viviana, additional, Galicchio, Santiago, additional, De Grandis, Elizabeth S., additional, Mestre, Graciela, additional, Escobal, Nidia, additional, Matarrese, Pablo, additional, Viollaz, Rocío, additional, Agostinho, Ariela, additional, Díez, Cecilia, additional, Cresta, Araceli, additional, Cabrera, Analía, additional, Blanco, Virginia, additional, Ferrero, Hilario, additional, Gambarini, Victoria, additional, Sosa, Patricia, additional, Bouquet, Cecilia, additional, Caramuta, Luciana, additional, Guisande, Silvina, additional, Gamboni, Beatriz, additional, Hassan, Amal, additional, Pesce, Laura, additional, Argumedo, Laura, additional, Dlugoszewski, Corina, additional, Demartini, Martha Graciela, additional, and Panico, Luis Ramón, additional

Published
2014
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