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6. Why are so huge differences reported in the occurrence rate of skin lipohypertrophy? Does it depend on method defects or on lack of interest?

Author

Brancario, C., Corigliano, M., Cozzolino, G., Improta, M.R., Fasolino, A., Lamberti, C., Lapice, M., Martino, C., Oliva, D., Raffaele, A., Selleri, A., Simonetti, R., Stile, A., Vecchiato, A., Vetrano, A., Volpe, P., Caputo, G., Del Sorbo, A., Di Capua, M.G., Durazzo, G., Egidio, M., Garofalo, G., Grasso, L., Meo, A., Murano, A., Perillo, L., Procida, R., Vietsi, F., Gentile, S., Strollo, F., and Guarino, G.

Published
2019
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12. Civil Wastewater Remediation through Employment of Indigenous Microalgae and Sewage Sludge

Author

Lima S., D'Agostino N., Brucato A., Caputo G., Grisafi F., Scargiali F., Lima S., D'Agostino N., Brucato A., Caputo G., Grisafi F., and Scargiali F.

Subjects
Settore ING-IND/25 - Impianti Chimici, bioreactors, wastewater, MICROALGAE
Abstract

Microalgae are photosynthetic microorganisms that can employ some inorganic pollutant compounds as nutrients, for example nitrates and phosphates. Traditional wastewater treatment comprises oxidation ponds in which the Activated Sludge performs the oxidation of the organic matter. Microalgae may be well applied in these processes. In this work, we tested the potential of remediation of a mixture of a local microalga, Chlorella sp. Pozzillo, and activated sludge and compared it to controls of only microalga and only activated sludge. We found that the mixture of bacteria and microalgae leads to an improvement in nitrogen removal up to the 83,68%, while phosphorous removal is improved when the autochthonous microalgae are used alone. The abatement of the Chemical Oxygen Demand was of 59,17% when using the microalgae and activated sludge consortium, while it was higher (-76,67%±0) when using the only activated sludge. The biomass was also analysed for its content in lipids and carbohydrates. This information may be useful to assess the best industrial application for the biomass obtained from civil wastewaters remediation process, in accordance with principles of circular economy and waste-to-resources view.

Published
2022

16. Sociologie et littérature face à la question du travail: le cas italien

Author

Orientale Caputo G., Lazzarin S., Orientale Caputo, G., and Lazzarin, S.

Subjects
sociologie, littérature, usage sociologique des sources littéraires, représentation littéraire du travail, précarité, marché du travail en Italie sociology, literature, sociological approach to literary texts, literary representation of employment and labour market, temporary employments, labor market in Italy
Abstract

Cette étude se propose de réfléchir sur le rapport entre sociologie et littérature, en revenant sur la question cruciale – et toujours ouverte – de la légitimité de l’usage sociologique des sources littéraires. Il s’agira notamment ici d’enquêter sur une articulation particulière de cette relation, le récit littéraire du monde du travail, en examinant plus spécifiquement le cas italien. À l’instar d’autres pays occidentaux – mais peut-être plus qu’eux – l’Italie a expérimenté les transformations récentes du monde du travail (flexibilité, précarisation, parcellisation), et elle a produit, ces vingt dernières années, une grande quantité de textes littéraires qui mettent en scène de tels changements en tâchant de les interpréter. This essay aims to reflect upon the relationship between sociology and literature as well as upon the crucial issue – on which scholars haven’t yet agreed – of whether literary sources can be interpreted using a sociological approach. In particular, this will involve addressing literary renderings of employment, labour market, and working life, looking more specifically at the Italian case. Like other western countries – but perhaps to an even larger extent – Italy has recently experienced significant transformations in the labour market and its employment conditions (workplace flexibility, temporary employments, fragmentation of the labour force) and has produced a large number of literary texts that address these transformations and attempt to interpret them.

Published
2022

23. Figure Disembedding: The Gottschaldt's Hidden Figure Test in Children with Typical Development and Autism

Author

Conson M., Siciliano M., Trojano L., Zoccolotti P., Zappullo I., Baiano C., Caputo G., Russo A., Cecere R., Di Rosa A., Esposito G., Milo R., Polito F., Rauso B., Vela M., Santangelo G., Conson, M., Siciliano, M., Trojano, L., Zoccolotti, P., Zappullo, I., Baiano, C., Caputo, G., Russo, A., Cecere, R., Di Rosa, A., Esposito, G., Milo, R., Polito, F., Rauso, B., Vela, M., and Santangelo, G.

Subjects
Perceptual style, Autism Spectrum Disorder, Cognition, medicine.disease, Perception of detail, Large sample, Test (assessment), Developmental psychology, Age groups, Developmental and Educational Psychology, medicine, Normative, Autism, Humans, Hidden figure, Autistic Disorder, Psychology, Child, Time score, Figure disembedding, Socioeconomic differences
Abstract

In two studies, we used the Gottschaldt’s Hidden Figure Test (GHFT) for assessing figure disembedding ability in children aged 7–11. Study 1 demonstrated in a large sample of typically developing children that GHFT accuracy and time scores differed across age groups, without sex and socioeconomic differences. Thus, we provided normative data only taking into account children’s age. In Study 2, GHFT normative values were used to assess children with autism, who were also compared with a closely age-matched group of typical controls. Children with autism achieved time scores at or above the 50th centile and significantly differed from the controls for time score. The GHFT seems a valuable tool for defining the cognitive profile of children with autism.

Published
2021

24. Supercritical water gasification of waste oils as a source of syngas

Author

Maniscalco M., Iannotta P., Scargiali F., Grisafi F., Brucato A., Caputo G., Maniscalco M., Iannotta P., Scargiali F., Grisafi F., Brucato A., and Caputo G.

Subjects
SCWG, supercritical water gasification, waste olis, syngas
Abstract

A huge amount of waste oil is produced worldwide. Also substantial amount of virgin oils is available that are interesting candidates for upgrading into syngas. Supercritical water gasification (SCWG) can be considered as an aqueous phase reforming process to produce syngas from oils. In this work, a variety of waste and virgin oils were gasified in a continuous down-flow autoclave reactor at supercritical conditions. Experiments were carried out at 430 °C and 660 °C, 25 MPa, with a residence time in the range 103-170 s, in order to investigate gasification and carbon efficiency, hydrogen yield and composition of the produced gas. All the analysed feedstocks were suspended in water at various concentrations before gasification. Pyrolysis bio-oil showed a gasification efficiency of 74 % and 86 % for mixtures with 3 and 10 oil/water wt ratio, respectively. Waste motor oil, suspended in water at a concentration of 1 % wt thanks to the use of surfactants, was successfully gasified with a gasification efficiency of 73 %. Virgin motor oil gasification efficiency higher than 60% had been obtained for both analysed concentrations (5 % wt and 10 % wt of oil). Gasification of rapeseed oil at 5 % wt showed a gasification efficiency close to 88 %. On the contrary, the gasification of sunflower oil at 430 °C showed that this temperature is not high enough to obtain acceptable gasification efficiencies that varied from 20 % to 15 % for concentrations of oil from 2 % wt to 8 % wt, respectively. The analysis of the gas composition, in all the studied cases, showed that the obtained gas stream was rich in H2, CH4 and CO2, with variable quantities of light hydrocarbons (C2H4, C2H6 and C3H8).

Published
2021

26. Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at root s(NN)=5.02 TeV

Author

Sirunyan, A. M., Tumasyan, A., Adam, W., Ambrogi, F., Bergauer, T., Dragicevic, M., Ero, J., Del, Valle, Escalante, A., Flechl, M., Fruhwirth, R., Jeitler, M., Krammer, N., Kratschmer, I, Liko, D., Madlener, T., Mikulec, I, Rad, N., Schieck, J., Schofbeck, R., Spanring, M., Waltenberger, W., Wulz, C-E, Zarucki, M., Drugakov, V, Mossolov, V, Gonzalez, Suarez, J., Darwish, M. R., Wolf, De, E. A., Croce, Di, Janssen, D., Kello, X., Lelek, T., Pieters, A., Sfar, M., Rejeb, H., Van, Haevermaet, Van, Mechelen, Van, Putte, Van, Remortel, Blekman, N., Bols, F., Chhibra, E. S., D'Hondt, S. S., Clercq, De, Lontkovskyi, J., Lowette, D., Marchesini, S., Moortgat, I, Python, S., Tavernier, Q., Van, Doninck, Van, Mulders, Beghin, P., Bilin, D., Clerbaux, B., Lentdecker, De, Delannoy, G., Dorney, H., Favart, B., Grebenyuk, L., Kalsi, A., Moureaux, A. K., Popov, L., Postiau, A., Starling, N., Thomas, E., L. V., Velde, Er, Vanlaer, C., Vannerom, P., Cornelis, D., Dobur, T., Khvastunov, D., Niedziela, I, Roskas, M., Skovpen, C., Tytgat, K., Verbeke, M., Vermassen, W., Vit, B., Bruno, M., Caputo, G., David, C., Delaere, P., Delcourt, C., Giammanco, M., Lemaitre, A., Prisci, V, Aro, J., Saggio, A., Vischia, P., Zobec, J., Alves, G. A., Silva, Correia, G., Hensel, C., Moraes, A., Batista Das Chagas, Belchior, E., Carvalho, W., Chinellato, J., Coelho, E., Costa, Da, E. M., Silveira, Da, Damiao, G. G., De Jesus, D., Martins, De Oliveira, C., Souza, De, Fonseca, S., Malbouisson, H., Martins, J., Figueiredo, Matos, D., Jaime, Medina, M., Almeida, De, Melo, M., Herrera, Mora, C., Mundim, L., Nogima, H., Prado Da Silva, Teles, W. L., Rebello, P., Rosas, Sanchez, L. J., Santoro, A., Sznajder, A., Thiel, M., Tonelli, Manganote, E. J., Da Silva De Araujo, Torres, F., Pereira, Vilela, A., Bernardes, C. A., Calligaris, L., Fern, ez Perez Tomei, Gregores, T. R., Lemos, E. M., Mercadante, D. S., Novaes, P. G., Padula, S. F., S, Ra, S., Aleks, Rov, Antchev, A., Hadjiiska, G., Iaydjiev, R., Misheva, P., Rodozov, M., Shopova, M., Sultanov, M., Bonchev, G., Dimitrov, M., Ivanov, A., Litov, T., Pavlov, L., Petkov, B., Petrov, P., Fang, A., Gao, W., Yuan, X., Ahmad, L., Hu, M., Wang, Z., Chen, Y., Chen, G. M., Chen, H. S., Jiang, M., Leggat, C. H., Liao, D., Liu, H., Spiezia, Z., Tao, A., Yazgan, J., Zhang, E., Zhang, H., Zhao, S., Agapitos, J., Ban, A., Levin, G., Li, A., Li, J., Li, L., Mao, Q., Qian, Y., Wang, S. J., Wang, D., Xiao, Q., Avila, M., Cabrera, C., Florez, A., Gonzalez, Hern, C. F., Ez, Segura, Delgado, M. A., Mejia, Guisao, Ruiz, Alvarez, J. D., Salazar, Gonzalez, C. A., Vanegas, Arbelaez, Godinovic, N., Lelas, N., Puljak, D., Sculac, I, Antunovic, T., Kovac, Z., Brigljevic, M., Ferencek, V, Kadija, D., Mesic, K., Roguljic, B., Starodumov, M., Susa, A., Ather, T., Attikis, M. W., Erodotou, A., Ioannou, E., Kolosova, A., Konstantinou, M., Mavromanolakis, S., Mousa, G., Nicolaou, J., Ptochos, C., Razis, F., Rykaczewski, P. A., Saka, H., Tsiakkouri, H., Finger, D., Finger, M., r. M., J, Kveton, A., Tomsa, J., Ayala, E., Jarrin, Carrera, E., Mahmoud, M. A., Mohammed, Y., Bhowmik, S., Antunes De Oliveira, Carvalho, A., Dewanjee, R. K., Ehataht, K., Kadastik, M., Raidal, M., Veelken, C., Eerola, P., Forthomme, L., Kirschenmann, H., Osterberg, K., Voutilainen, M., Garcia, F., Havukainen, J., Heikkila, J. K., Karimaki, V, Kim, M. S., Kinnunen, R., Lampen, T., Lassila-Perini, K., Laurila, S., Lehti, S., Linden, T., Siikonen, H., Tuominen, E., Tuominiemi, J., Luukka, P., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Ferri, F., Ganjour, S., Givernaud, A., Gras, P., Monchenault, De, Hamel, G., Jarry, P., Leloup, C., Lenzi, B., Locci, E., Malcles, J., R, Er, Rosowsky, J., Sahin, A., Savoy-Navarro, M. O., Titov, A., Yu, M., Ahuja, G. B., Amendola, S., Beaudette, C., Bonanomi, F., Busson, M., Charlot, P., Diab, C., Falmagne, B., Cassagnac, De, Granier, R., Kucher, I, Lobanov, A., Perez, Martin, C., Nguyen, M., Och, O, Paganini, C., Rembser, P., Salerno, J., Sauvan, R., Sirois, J. B., Zabi, Y., Zghiche, A., Agram, A., J-L, Rea, Bloch, J., Bourgatte, D., Brom, G., J-M, Chabert, Collard, E. C., Conte, C., Fontaine, E., J-C, Gele, Goerlach, D., Grimault, U., Bihan, Le, A-C, Tonon, Van, Hove, Gadrat, P., Beauceron, S., Bernet, S., Boudoul, C., Camen, G., Carle, C., Chanon, A., Chierici, N., Contardo, R., Depasse, D., Mamouni, El, Fay, H., Gascon, J., Gouzevitch, S., Ille, M., Jain, B., Laktineh, Sa, Lattaud, I. B., Lesauvage, H., Lethuillier, A., Mirabito, M., Perries, L., Sordini, S., Torterotot, V, Touquet, L., G. V., Donckt, Er, Viret, M., Toriashvili, S., Tsamalaidze, T., Autermann, Z., Feld, C., Klein, L., Lipinski, K., Meuser, M., Pauls, D., Preuten, A., Rauch, M., Schulz, M. P., Teroerde, J., Erdmann, M., Fischer, M., Ghosh, B., Hebbeker, S., Hoepfner, T., Keller, K., Mastrolorenzo, H., Merschmeyer, L., Meyer, M., Millet, A., Mocellin, P., Mondal, G., Mukherjee, S., Noll, S., Novak, D., Pook, A., Pozdnyakov, T., Quast, A., Radziej, T., Rath, M., Reithler, Y., Roemer, H., Schmidt, J., Schuler, A., Sharma, S. C., Wiedenbeck, A., Zaleski, S., Flugge, S., Ahmad, G., Haj, W., Hlushchenko, O., Kress, T., Muller, T., Nowack, A., Pistone, C., Pooth, O., Roy, D., Sert, H., Stahl, A., Martin, Aldaya, M., Asmuss, P., Babounikau, I, Bakhshiansohi, H., Beernaert, K., Behnke, O., Martinez, Bermudez, A., Bin, Anuar, Borras, A. A., Botta, K., Campbell, V, Cardini, A., Connor, A., Rodriguez, P., Consuegra, S., Contreras-Campana, C., Danilov, V, Wit, De, Defranchis, A., Pardos, M. M., Diez, C., Damiani, Dominguez, D., Eckerlin, G., Eckstein, D., Eichhorn, T., Elwood, A., Eren, E., Banos, Estevez, L. I., Gallo, E., Geiser, A., Grohsjean, A., Guthoff, M., Haranko, M., Harb, A., Jafari, A., Jomhari, N. Z., Jung, H., Kasem, A., Kasemann, M., Kaveh, H., Keaveney, J., Kleinwort, C., Knolle, J., Krucker, D., Lange, W., Lenz, T., Lidrych, J., Lipka, K., Lohmann, W., Mankel, R., Melzer-Pellmann, I-A, Meyer, A. B., Missiroli, M., Mnich, J., Mussgiller, A., Myronenko, V, Adan, Perez, D., Pflitsch, S. K., Pitzl, D., Raspereza, A., Saibel, A., Savitskyi, M., Scheurer, V, Schutze, P., Schwanenberger, C., Shevchenko, R., Singh, A., Ricardo, Sosa, R. E., Tholen, H., Turkot, O., Vagnerini, A., Van De Klundert, Walsh, M., Wen, R., Wichmann, Y., Wissing, K., Zenaiev, C., Zlebcik, O., Aggleton, R., Bein, R., Benato, S., Benecke, L., Dreyer, A., Ebrahimi, T., Feindt, A., Frohlich, F., Garbers, A., Garutti, C., Gonzalez, E., Gunnellini, D., Haller, P., Hinzmann, J., Karavdina, A., Kasieczka, A., Klanner, G., Kogler, R., Kovalchuk, R., Kurz, N., Kutzner, S., Lange, V, Lange, J., Malara, T., Multhaup, A., Niemeyer, J., Reimers, C. E. N., Rieger, A., Schleper, O., Schumann, P., Schw, S., T, J., Sonneveld, J., Stadie, H., Steinbruck, G., Vormwald, B., Zoi, I, Akbiyik, M., Baselga, M., Baur, S., Berger, T., Butz, E., Caspart, R., Chwalek, T., Boer, De, Dierlamm, W., Morabit, El, Faltermann, K., Giffels, N., Gottmann, M., Hartmann, A., Heidecker, F., Husemann, C., Iqbal, U., Kudella, M. A., Maier, S., Mitra, S., Mozer, S., Muller, M. U., Muller, D., Musich, Th, Nurnberg, M., Rabbertz, G., Savoiu, K., Schafer, D., Schnepf, D., Schroder, M., Shvetsov, M., Simonis, I, Ulrich, H. J., Wassmer, R., Weber, M., Wohrmann, M., Wolf, C., Wozniewski, R., Anagnostou, S., Asenov, G., Daskalakis, P., Geralis, G., Kyriakis, T., Loukas, A., Paspalaki, D., Stakia, G., Diamantopoulou, A., Karathanasis, M., Kontaxakis, G., Manousakis-katsikakis, P., Panagiotou, A., Papavergou, A., Saoulidou, I, Theofilatos, N., Vellidis, K., Vourliotis, K., Bakas, E., Kousouris, G., Papakrivopoulos, K., Tsipolitis, I, Zacharopoulou, G., Evangelou, A., Foudas, I, Gianneios, C., Katsoulis, P., Kokkas, P., Mallios, P., Manitara, S., Manthos, K., Papadopoulos, N., Strologas, I, Triantis, J., Tsitsonis, F. A., Bartok, D., Chudasama, M., Csanad, R., Major, M., P. M., Al, K., Mehta, A., Pasztor, G., Suranyi, O., Veres, I, Bencze, G., Hajdu, G., Horvath, C., Sikler, D., Veszpremi, F., Vesztergombi, V., Beni, G., Czellar, N., Karancsi, S., Molnar, J., Szillasi, J., Raics, Z., Teyssier, P., Trocsanyi, D., Ujvari, Z. L., Csorgo, B., Metzger, T., Nemes, W. J., Novak, F., Choudhury, T., Komaragiri, S., Tiwari, J. R., Bahinipati, P. C., Kar, S., Kole, C., Mal, G., Bindhu, P., Muraleedharan Nair, V. K., Nayak, A., Sahoo, D. K., Swain, S. K., Bansal, S., Beri, S. B., Bhatnagar, V, Chauhan, S., Dhingra, N., Gupta, R., Kaur, A., Kaur, M., Kaur, S., Kumari, P., Lohan, M., Meena, M., Eep, S, Sharma, K., Singh, S., Virdi, J. B., Walia, A. K., Bhardwaj, G., Choudhary, A., Garg, B. C., Gola, R. B., Keshri, M., Kumar, S., Ashok, Naimuddin, Priyanka, M., Ranjan, P., Shah, K., Aashaq, Sharma, Bhardwaj, R., Bharti, R., Bhattacharya, M., Bhattacharya, R., Bhaw, S., Eep, U., Bhowmik, D., Dutta, S., Ghosh, S., Gomber, B., Maity, M., Mondal, K., N, An, Purohit, S., Rout, A., Saha, P. K., Sarkar, G., Sharan, S., Singh, M., Thakur, B., Behera, S., Behera, P. K., Kalbhor, S. C., Muhammad, P., Pujahari, A., Sharma, P. R., Sikdar, A., Dutta, A. K., Jha, D., Mishra, V, Netrakanti, D. K., Pant, P. K., Shukla, L. M., Aziz, P., Bhat, T., Dugad, M. A., Mohanty, S., Sur, G. B., Verma, N., Ravindra, Kumar, Banerjee, S., Bhattacharya, S., Chatterjee, S., Das, P., Guchait, M., Karmakar, S., Majumder, G., Mazumdar, K., Sahoo, N., Sawant, S., Dube, S., Kansal, B., Kapoor, A., Kothekar, K., P, Ey, Rane, S., Rastogi, A., Sharma, A., Chenarani, S., Etesami, S., Khakzad, S. M., Najafabadi, M., Mohammadi, M., Naseri, M., Hosseinabadi, Rezaei, F., Felcini, M., Grunewald, M., Abbrescia, M., Aly, R., Calabria, C., Colaleo, A., Creanza, D., Cristella, L., Filippis, De, Palma, De, Florio, Di, Elmetenawee, A., Fiore, W., Gelmi, L., Iaselli, A., Ince, G., Lezki, M., Maggi, S., Maggi, G., Merlin, M., Miniello, J. A., My, G., Nuzzo, S., Pompili, S., Pugliese, A., Radogna, G., Ranieri, R., Selvaggi, A., Silvestris, G., Simone, L., Venditti, F. M., Verwilligen, R., Abbiendi, P., Battilana, G., Bonacorsi, C., Borgonovi, D., Braibant-Giacomelli, L., Campanini, S., Capiluppi, R., Castro, P., Cavallo, A., Codispoti, F. R., Cuffiani, G., Dallavalle, M., Fabbri, G. M., Fanfani, F., Fontanesi, A., Giacomelli, E., Giommi, P., Gr, L., I, C., Guiducci, L., Iemmi, F., Meo, Lo, Marcellini, S., Masetti, S., Navarria, G., Perrotta, F. L., Primavera, A., Rossi, F., Rovelli, A. M., Siroli, T., Tosi, G. P., Albergo, N., Costa, S., Mattia, Di, Potenza, A., Tricomi, R., Tuve, A., Barbagli, C., Cassese, G., Ceccarelli, A., Ciulli, R., Civinini, V, D'Aless, C., Ro, R., Fiori, F., Focardi, E., Latino, G., Lenzi, P., Meschini, M., Paoletti, S., Sguazzoni, G., Viliani, L., Benussi, L., Bianco, S., Piccolo, D., Bozzo, M., Ferro, F., Mulargia, R., Robutti, E., Tosi, S., Benaglia, A., Beschi, A., Brivio, F., Ciriolo, V, Dinardo, M. E., Dini, P., Gennai, S., Ghezzi, A., Govoni, P., Guzzi, L., Malberti, M., Malvezzi, S., Menasce, D., Monti, F., Moroni, L., Paganoni, M., Pedrini, D., Ragazzi, S., Fatis, De, Tabarelli, T., Valsecchi, D., Zuolo, D., Buontempo, S., Cavallo, N., Iorio, De, Crescenzo, Di, Fabozzi, A., Fienga, F., Galati, F., Iorio, G., Layer, A. O. M., Lista, L., Meola, L., Paolucci, S., Rossi, P., Sciacca, B., Voevodina, C., Azzi, E., Bacchetta, P., Bisello, N., Boletti, D., Bragagnolo, A., Carlin, A., Checchia, R., Manzano, P., De Castro, P., Dorigo, T., Dosselli, U., Gasparini, F., Gasparini, U., Gozzelino, A., Hoh, S. Y., Margoni, M., Meneguzzo, A. T., Pazzini, J., Presilla, M., Ronchese, P., Rossin, R., Simonetto, F., Tiko, A., Tosi, M., Zanetti, M., Zotto, P., Zucchetta, A., Zumerle, G., Braghieri, A., Fiorina, D., Montagna, P., Ratti, S. P., Re, V, Ressegotti, M., Riccardi, C., Salvini, P., Vai, I, Vitulo, P., Biasini, M., Bilei, G. M., Ciangottini, D., Fano, L., Lariccia, P., Leonardi, R., Manoni, E., Mantovani, G., Mariani, V, Menichelli, M., Rossi, A., Santocchia, A., Spiga, D., Rosov, K., Azzurri, P., Bagliesi, G., Bertacchi, V, Bianchini, L., Boccali, T., Castaldi, R., Ciocci, M. A., Dell'Orso, R., Donato, S., Giannini, L., Giassi, A., Grippo, M. T., Ligabue, F., Manca, E., Orli, M, Messineo, G., Palla, A., Rizzi, F., Rol, A., I, G., Chowdhury, Roy, S., Scribano, A., Spagnolo, P., Tenchini, R., Tonelli, G., Turini, N., Venturi, A., Verdini, P. G., Cavallari, F., Cipriani, M., Del, Re, Marco, Di, Diemoz, E., Longo, M., Meridiani, E., Organtini, P., G. P., Olfi, F., Paramatti, R., Quaranta, C., Rahatlou, S., Rovelli, C., Santanastasio, F., Soffi, L., Tramontano, R., Amapane, N., Arcidiacono, R., Argiro, S., Arneodo, M., Bartosik, N., Bellan, R., Bellora, A., Biino, C., Cappati, A., Cartiglia, N., Cometti, S., Costa, M., Covarelli, R., Demaria, N., Fern, Ez, Gonzalez, J. R., Kiani, B., Legger, F., Mariotti, C., Maselli, S., Migliore, E., Monaco, V, Monteil, E., Monteno, M., Obertino, M. M., Ortona, G., Pacher, L., Pastrone, N., Pelliccioni, M., Angioni, Pinna, G. 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R., Tabb, B., Agarwal, W., Harrington, G., Iashvili, C., Kharchilava, I., Mclean, A., Nguyen, C., Parker, D., Pekkanen, A., Rappoccio, J., Roozbahani, S., Alverson, B., Barberis, G., Freer, E., Haddad, C., Hortiangtham, Y., Madigan, A., Marzocchi, G., Morse, B., Nguyen, D. M., Orimoto, V, Skinnari, T., Tishelman-Charny, L., Wamorkar, A., Wang, T., Wisecarver, B., Wood, A., Bhattacharya, D., Bueghly, S., Fedi, J., Gilbert, G., Gunter, A., Hahn, T., Odell, K. A., Schmitt, N., Sung, M. H., Velasco, K., Bucci, M., Dev, R., Goldouzian, N., Hildreth, R., Anampa, M., Hurtado, K., Jessop, C., Karmgard, D. J., Lannon, K., Li, W., Loukas, N., Marinelli, N., Mcalister, I, Meng, F., Musienko, Y., Ruchti, R., Siddireddy, P., Smith, G., Taroni, S., Wayne, M., Wightman, A., Wolf, M., Alimena, J., Bylsma, B., Cardwell, B., Durkin, L. S., Francis, B., Hill, C., Ji, W., Lefeld, A., Ling, T. Y., Winer, B. L., Dezoort, G., Elmer, P., Hardenbrook, J., Haubrich, N., Higginbotham, S., Kalogeropoulos, A., Kwan, S., Lange, D., Lucchini, M. T., Luo, J., Marlow, D., Mei, K., Ojalvo, I, Olsen, J., Palmer, C., Piroue, P., Stickl, D., Tully, C., Malik, S., Norberg, S., Barker, A., Barnes, V. E., Chawla, R., Das, S., Gutay, L., Jones, M., Jung, A. W., Mahakud, B., Miller, D. H., Negro, G., Neumeister, N., Peng, C. C., Piperov, S., Qiu, H., Schulte, J. F., Trevisani, N., Wang, F., Xiao, R., Xie, W., Cheng, T., Dolen, J., Parashar, N., Baty, A., Behrens, U., Dildick, S., Ecklund, K. M., Freed, S., Geurts, F. J. M., Kilpatrick, M., Kumar, Arun, Padley, B. P., Redjimi, R., Roberts, J., Rorie, J., Shi, W., Leiton, Stahl, A. G., Tu, Z., Zhang, A., Bodek, A., Barbaro, De, Demina, P., Dulemba, R., Fallon, J. L., Ferbel, C., Galanti, T., Garcia-Bellido, M., Hindrichs, A., Khukhunaishvili, O., Ranken, A., Taus, E., Chiarito, R., Chou, B., J. P. G., Rakota, A., Gershtein, Y., Halkiadakis, E., Hart, A., Heindl, M., Hughes, E., Kaplan, S., Laflotte, I, Lath, A., Montalvo, R., Nash, K., Osherson, M., Salur, S., Schnetzer, S., Somalwar, S., Stone, R., Thomas, S., Acharya, H., Delannoy, A. G., Spanier, S., Bouhali, O., Dalchenko, M., Mattia, De, Delgado, M., Eusebi, A., Gilmore, R., Huang, J., Kamon, T., Kim, T., Luo, H., Malhotra, S., Marley, S., Mueller, D., Overton, R., Pernie, D., Rathjens, L., Safonov, D., Akchurin, A., Damgov, N., Guio, De, Hegde, F., Kunori, V, Lamichhane, S., Mengke, S. W., Muthumuni, T., Peltola, S., Undleeb, T., Volobouev, S., Wang, I, Whitbeck, Z., Greene, A., Gurrola, S., Janjam, A., Johns, R., Maguire, W., Melo, C., Ni, A., Padeken, H., Romeo, K., Sheldon, F., Tuo, P., Velkovska, S., Verweij, J., Arenton, M., Barria, M. W., Cox, P., Cummings, B., Hakala, G., Hirosky, J., Joyce, R., Ledovskoy, M., Neu, A., Tannenwald, C., Wang, B., Wolfe, Y., Xia, E., Harr, F., Karchin, R., Poudyal, P. E., Sturdy, N., Thapa, J., Black, P., Bose, K., Buchanan, T., Caillol, J., Carlsmith, C., Dasu, D., Bruyn, De, Dodd, I, Galloni, L., He, C., Herndon, H., Herve, M., Hussain, A., Lanaro, U., Loeliger, A., Loveless, A., Sreekala, R., Madhusudanan, J., Mallampalli, A., Pinna, D., Ruggles, T., Savin, A., Sharma, V, Smith, W. H., Teague, D., Trembath-reichert, S., and Cms, Collaboration

Subjects
MODEL, Physics and Astronomy, High Energy Physics::Experiment, QUARK-GLUON PLASMA, Nuclear Experiment
Abstract

The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (Pb-Pb) collisions at a center-of-mass energy of root s(NN) = 5.02 TeV per nucleon pair, using the decay chain X(3872) -> J/psi pi(+)pi(-) -> mu(+) mu(-) pi(+)pi(-). The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb(-1). The measurement is performed in the rapidity and transverse momentum ranges vertical bar y vertical bar < 1.6 and 15 < p(T) < 50 GeV/c. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to psi 2S yield ratio is found to be rho(Pb-Pb) = 1.08 +/- 0.49(stat) +/- 0.52(syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.

Published
2022

30. Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

Author

Ekkapongpisit M, Giovia A, Follo C, Caputo G, and Isidoro C

Subjects
Medicine (General), R5-920
Abstract

Maneerat Ekkapongpisit,1 Antonino Giovia,1 Carlo Follo,1 Giuseppe Caputo,2,3 Ciro Isidoro11Laboratory of Molecular Pathology and Nanobioimaging, Department of Health Sciences, Università del Piemonte Orientale “A Avogadro”, Novara, 2Dipartimento di Chimica dell’Università di Torino, Torino, 3Cyanine Technology SpA, Torino, ItalyBackground and methods: Nanoparticles engineered to carry both a chemotherapeutic drug and a sensitive imaging probe are valid tools for early detection of cancer cells and to monitor the cytotoxic effects of anticancer treatment simultaneously. Here we report on the effect of size (10–30 nm versus 50 nm), type of material (mesoporous silica versus polystyrene), and surface charge functionalization (none, amine groups, or carboxyl groups) on biocompatibility, uptake, compartmentalization, and intracellular retention of fluorescently labeled nanoparticles in cultured human ovarian cancer cells. We also investigated the involvement of caveolae in the mechanism of uptake of nanoparticles.Results: We found that mesoporous silica nanoparticles entered via caveolae-mediated endocytosis and reached the lysosomes; however, while the 50 nm nanoparticles permanently resided within these organelles, the 10 nm nanoparticles soon relocated in the cytoplasm. Naked 10 nm mesoporous silica nanoparticles showed the highest and 50 nm carboxyl-modified mesoporous silica nanoparticles the lowest uptake rates, respectively. Polystyrene nanoparticle uptake also occurred via a caveolae-independent pathway, and was negatively affected by serum. The 30 nm carboxyl-modified polystyrene nanoparticles did not localize in lysosomes and were not toxic, while the 50 nm amine-modified polystyrene nanoparticles accumulated within lysosomes and eventually caused cell death. Ovarian cancer cells expressing caveolin-1 were more likely to endocytose these nanoparticles.Conclusion: These data highlight the importance of considering both the physicochemical characteristics (ie, material, size and surface charge on chemical groups) of nanoparticles and the biochemical composition of the cell membrane when choosing the most suitable nanotheranostics for targeting cancer cells.Keywords: nanoparticles, imaging, lysosomes, vesicular traffic, ovarian cancer, caveolin

Published
2012

31. Labeling and exocytosis of secretory compartments in RBL mastocytes by polystyrene and mesoporous silica nanoparticles

Author

Ekkapongpisit M, Giovia A, Nicotra G, Ozzano M, Caputo G, and Isidoro C

Subjects
Medicine (General), R5-920
Abstract

Maneerat Ekkapongpisit1,*, Antonino Giovia1,*, Giuseppina Nicotra1, Matteo Ozzano1, Giuseppe Caputo2,3, Ciro Isidoro1 1Laboratory of Molecular Pathology and Nanobioimaging, Department of Health Sciences, Università del Piemonte Orientale "A. Avogadro", Novara, Italy; 2Department of Chemistry, University of Turin, Turin, 3Cyanine Technology SpA, Torino, Italy *These authors contributed equally to this workBackground: For a safe ‘in vivo’ biomedical utilization of nanoparticles, it is essential to assess not only biocompatibility, but also the potential to trigger unwanted side effects at both cellular and tissue levels. Mastocytes (cells having secretory granules containing cytokines, vasoactive amine, and proteases) play a pivotal role in the immune and inflammatory responses against exogenous toxins. Mastocytes are also recruited in the tumor stroma and are involved in tumor vascularization and growth.Aim and methods: In this work, mastocyte-like rat basophilic leukemia (RBL) cells were used to investigate whether carboxyl-modified 30 nm polystyrene (PS) nanoparticles (NPs) and naked mesoporous silica (MPS) 10 nm NPs are able to label the secretory inflammatory granules, and possibly induce exocytosis of these granules. Uptake, cellular retention and localization of fluorescent NPs were analyzed by cytofluorometry and microscope imaging.Results: Our findings were that: (1) secretory granules of mastocytes are accessible by NPs via endocytosis; (2) PS and MPS silica NPs label two distinct subpopulations of inflammatory granules in RBL mastocytes; and (3) PS NPs induce calcium-dependent exocytosis of inflammatory granules.Conclusion: These findings highlight the value of NPs for live imaging of inflammatory processes, and also have important implications for the clinical use of PS-based NPs, due to their potential to trigger the unwanted activation of mastocytes.Keywords: secretory lysosomes, inflammation, nanoparticles, vesicular traffic

Published
2012

40. Locally advanced breast implant-associated anaplastic large-cell lymphoma: A combined medical-surgical approach

Author

Caputo, G. G., Alban, A., D'Ali, L., Mariuzzi, L., Galvano, F., and Parodi, P. C.

Subjects
Brentuximab Vedotin, Lymphoma, Textured breast implant, Antineoplastic Agents, Breast Neoplasms, Neoadjuvant therapy in BIA-ALCL, Neoadjuvant Therapy, Large-Cell, Vincristine, Positron Emission Tomography Computed Tomography, Humans, Anaplastic, BIA-ALCL, Female, Immunotherapy, Breast implant anaplastic cell lymphoma, Lymphoma, Large-Cell, Anaplastic, Mastectomy
Published
2021

42. Contributor contact details

Author

Gugliuzza, A., primary, Basile, A., additional, Damle, A., additional, Charcosset, C., additional, Piemonte, V., additional, Di Paola, L., additional, Curcio, S., additional, Ricca, E., additional, Blasi, A., additional, Fiorenza, G., additional, Freda, C., additional, Calabrò, V., additional, da Costa, J., additional, Smart, S., additional, Liu, S., additional, Serra, J.M., additional, Genovese, A., additional, Villante, C., additional, Lo Faro, M., additional, Aricò, A.S., additional, Scott, K., additional, Cigolotti, V., additional, Devianto, H., additional, McPhail, S., additional, Moreno, A., additional, Giaconia, A., additional, Caputo, G., additional, Gugliuzza, A., additional, Capriccioli, A., additional, and Gormly, S., additional

Published
2014
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