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36. American Society of Colon and Rectal Surgeons 91st Annual Convention Podium and Poster abstracts: June 7–12, 1992 San Francisco, CA

Author

Lechner, P., Lind, P., Binter, G., Golub, R. W., Kerner, B. A., Wise, Jr., W. E., Meesig, D. M., Hartmann, R. F., Khanduja, K. S., Sayre, J. W., Aguilar, P. S., Guillem, J. G., Forde, K. A., Treat, M. R., Neugut, A. I., O'Toole, K. M., Diamond, B. E., Kewenter, J., Brevinge, H., Haglind, E., Limberg, B., Elles, C. N., Boggs, W. H., Slagle, G. H., Cole, P. A., Coyle, D. J., Smith, L. E., Orkin, B., Saclarides, T. J., Sheridan, W. G., Lowndes, R. H., Young, H. L., Wong, W. D., Rothenberger, D. A., Bartolo, D. C. C., Wexner, S. D., Ger, G. C., Jorge, J. M. N., Lee, E., Nogueras, J. J., Jagelman, D. G., McKenna, K., Koltun, W. A., Bute, B., Lichliter, W., Le, T., Timmcke, A., Gathright, J. B., Mascagni, D., Hojo, K., Moriya, Y., Sugihara, K., Di, G., Zenni, G. C., Abraham, K., Dobrin, P. B., Harford, F. J., Suzuki, K., Gunderson, L., Devine, R. M., Dozois, R. R., Cavaliere, F., Pemberton, J. H., Fazio, V., Cosimelli, M., Beart, R. W., Giannarelli, D., Moran, M., Ramos, A., Rothenberger, D., Goldberg, S., Antonenko, D., Heymen, S., Gulledge, A. D., Jakate, S., Saclarides, T., Heine, J. A., Williams, J. G., VanBergen, E. H., Buie, W. D., Goldberg, S. M., Davies, N., Yates, J., Jenkins, S. A., Taylor, B. A., Bapat, B., Stern, H., Berk, T., Parker, J., Ray, P. N., McLeod, R., Cohen, Z., Rowe, J. K., Zera, R. T., Madoff, R. D., Bubrick, M. P., Roberts, J. C., Johnston, G. R., Fenney, D. A., Farouk, R., Duthie, G. S., McCue, J. L., Phillips, R. K. S., Viamonte, M., Cole, J., Gottesman, L., Solomon, M. J., McLeod, R. S., Kern, K., Jensen, L. L., Lowry, A. C., Vernava, III, A. M., Longo, W. E., Daniel, G. L., Ehrenpreis, E., Stone, J. M., Cosman, B. C., Wolfe, V. A., Nino-Murcia, M., Perkash, I., Marcello, P. W., Roberts, P. L., Schoetz, Jr., D. J., Murray, J. J., Coller, J. A., Veidenheimer, M. C., Keighley, M. R. B., Grobler, S. P., Hosie, K. B., Schmitt, S. L., James, K., Lucas, F., Peck, Donald A., Ferrara, A., Grotz, R. L., Perry, R. E., Hanson, R. B., Lewis, W. G., Holdsworth, P. J., Sagar, P. M., Johnston, D., Perry, T. G., Strong, S. A., Fazio, V. W., Lavery, I. C., Oakley, J. R., Church, J. M., Milsom, J. W., Fozard, J. B. J., Nelson, H., Schneebaum, S., Arnold, M. W., Young, D., LaValle, G. J., Petty, L., Berens, A., Mojizisik, C., Martin, E. W., Hase, K., Shatney, C. H., Trollope, M., Johnson, D., Vierra, M., Deutsch, A. A., Tulchinsky, H., Nudelman, I., Gutman, H., Reiss, R., Taylor, Brian M., Araujo, A., Bleday, R., Jessurun, J., Heine, J., Rosen, Les, Sipe, Paul, Riether, Robert, Stasik, John, Sheets, James, Khubchandani, Indru, Reiter, W., Friedberg, G., Morey, G., Goldstein, E., Williamson, P., Larach, S., Senagore, A. J., Luchtefeld, M. A., MacKeigen, J. M., Mazier, W. P., Wengert, T., Ott, M. T., Bailey, H. R., Hartendorp, P., Dailey, T. H., Church, J. C., Johansen, O. B., Daniel, N., Korst, M., Kuijpers, H. C., Pena, J. P., Christenson, C. E., Balcos, E. G., Lewis, W., Mitchell, C., MacFie, J., Hildebrandt, U., Ecker, K. W., Kraus, J., Schmid, T., Feifel, G., Tjandra, J. J., Scoggin, Steve, Frazee, Richard C., Ambroze, Jr., W. L., Nezhat, C., Pennington, E., Nezhat, F., Stolfi, V. M., Thorson, A. G., Falk, P. M., Fitzgibbons, Jr, R. J., Luukkonen, P., Järvinen, H. J., James, E., Paty, P. B., Enker, W. E., Cohen, A. M., Lauwers, G. Y., Saad, R., Birnbaum, E., DeVos, W., Fry, R., Kodner, I., Fleshman, J., Cali, R. L., Pitsch, R. M., Blatchford, G. J., Christensen, M. A., Schroeder, T. K., Easley, K. A., Ellis, C. N., Cheape, J. D., Hull, T. L., Salanga, V., Kokoszka, Joseph, Andrianopoulos, Georgia, Nelson, Richard, Abcarian, Herand, Kumar, D., Benson, M. J., Roberts, J., Martin, J. E., Swash, M., Wingate, D. L., Williams, N. S., Orkin, B. A., Emsellem, H., Dent, John, Tissaw, M. A., Shafik, A., Abel, M. E., Chiu, Y. S. Y., Russell, T. R., Volpe, P. A., Casillas, G. L., Mashas, W. E., Eastman, D. A., Grace, R. H., Anderson, J. M., Hacker, K., Heryer, J., Conner, W., Rubin, R., Eisenstat, T., Salvati, E., Oliver, G., Duberman, E., Simmang, C. L., Fry, R. D., Kodner, I. J., Fleshman, J. W., Corman, M. L., Galandiuk, S., Weiner, G. J., Kahn, D., Mitchell, E., Abdel-Nabi, H., Block, G. E., Mannella, E., Tedesco, M., Anza, M., Civalleri, D., Di Tora, P., Capussotti, L., Morandi, G. B., Tirelli, C., Da Pian, P. P., Cortesi, E., Ruggeri, E., Fitzgerald, S. D., Davis, Faith, Bowen, Phyllis, Sutter, Eileen, Kikendall, Walter, McGannon, E., Brantley, P. A., Czyrko, C., Falardeau, C., Trepashko, Don, Skosey, John, Michelassi, F., Staniunas, R. J., Vignati, P. V., Beck, D. E., Karulf, R., Roettger, R., Braidt, J., Ruoff, K., Ackroyd, F., Shellito, P., Goh, H. S., Lin, L. W., Edwards, E., Farmer, J., Walters, C. A., Hyman, N. H., Hebert, J. C., Richman, Irving M., Staren, E. D., Sessions, S. C., Scoma, R. S., Clements, B., Smink, Jr., R. D., Arai, K., Sugita, A., Yamazaki, Y., Harada, H., Fukushima, T., Armstrong, D. N., Ballantyne, G. H., Sillin, L. F., Davie, R. J., Harding, L. K., Birch, N. J., Yamanouchi, T., Bayer, I., Mitmaker, B., Gordon, P. H., Wang, E., Kynaston, H., Edelstein, P. S., Thompson, S. M., Davies, R. J., Farmer, K. C. R., Oliver, S. E., Spigelman, A. D., Bennett, P., O'Kelly, T. J., Brading, A. F., Mortensen, N. J., Paul, P., McGannon, E. M., Huth, P., Hull-Boiner, S., Pezim, M. E., Johnson, H. W., Gillespie, K. D., Willard, P., Owen, D. A., Ramsey, P. S., Leu, S. Y., Hsu, H., Al-Humadi, Adil H., Eisman, E., Tries, J., Gupta, N. C., Frick, M. P., Boman, B. M., Franceschi, D., Eckhauser, M. L., Pritchard, T., Konsten, J., Baeten, C. G. M. I., Havenith, M. G., Soeters, P. B., Lau, P. W. K., Lorentz, T. G., Wong, J., and The III In-CYT-103 Immunoscintigraphy Study Group

Published
1992
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40. KRAS early testing: Consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an italian setting

Author

Barone, C., Giuliante, F., Adam, R., Pinto, C., Garufi, C., Folprecht, G., Falcone, Alfredo, Nuzzo, G., Van Cutsem, E., Ciardiello, F., Capussotti, L., Poston, G., Barone, C, Pinto, C, Normanno, N, Capussotti, L, Cognetti, F, Falcone, A, Mantovani, L, and Mantovani, LORENZO GIOVANNI

Subjects
Non-Clinical Medicine, Delphi Technique, Cost effectiveness, Colorectal cancer, Cost-Benefit Analysis, Cancer Treatment, lcsh:Medicine, Cetuximab, Colorectal Neoplasm, medicine.disease_cause, Cost Effectiveness, Antineoplastic Agent, Science Policy and Economics, Neoplasm Metastasis, lcsh:Science, Proto-Oncogene Protein, Multidisciplinary, Cost–benefit analysis, Health Care Costs, Cost-effectiveness analysis, Bevacizumab, Neoplasm Metastasi, Oncology, Italy, metastatic colorectal, Medicine, KRAS, Colorectal Neoplasms, Research Article, medicine.drug, Human, medicine.medical_specialty, KRAS testing, Science Policy, colorectal cancer, Antineoplastic Agents, Antibodies, Monoclonal, Humanized, Rectal Cancer, Proto-Oncogene Proteins p21(ras), Health Economics, Proto-Oncogene Proteins, Gastrointestinal Tumors, Cancer Detection and Diagnosis, Early Detection, medicine, Humans, Cost-Benefit Analysi, Intensive care medicine, neoplasms, Settore MED/06 - ONCOLOGIA MEDICA, Biochemistry, Genetics and Molecular Biology (all), business.industry, lcsh:R, kras, Cancers and Neoplasms, Chemotherapy and Drug Treatment, medicine.disease, ras Protein, digestive system diseases, Quality-adjusted life year, Surgery, Health Care Cost, Agricultural and Biological Sciences (all), ras Proteins, cetuximab or bevacizumab, lcsh:Q, Cost-Effectiveness, business
Abstract

KRAS testing is relevant for the choice of the most appropriate first-line therapy of metastatic colorectal cancer (CRC). Strategies for preventing unequal access to the test should be implemented, but their relevance in the practice is related to economic sustainability. The study adopted the Delphi technique to reach a consensus on several topics. Issues related to execution of KRAS testing were identified by an expert's board and proposed to 108 Italian oncologists and pathologists through two subsequent questionnaires. The emerging proposal was evaluated by decision analyses models employed by technology assessment agencies in order to assess cost-effectiveness. Alternative therapeutic strategies included most commonly used chemotherapy regimens alone or in combination with cetuximab or bevacizumab. The survey indicated that time interval for obtaining KRAS test should not exceed 15 days, 10 days being an optimal interval. To assure the access to proper treatment, a useful strategy should be to anticipate the test after radical resection in patients at high risk of relapse. Early KRAS testing in high risk CRC patients generates incremental cost-effectiveness ratios between 6,000 and 13,000 Euro per quality adjusted life year (QALY) gained. In extensive sensitivity analyses ICER's were always below 15,000 Euro per QALY gained, far within the threshold of 60,000 Euro/QALY gained accepted by regulatory institutions in Italy. In metastatic CRC a time interval higher than 15 days for result of KRAS testing limits access to therapeutic choices. Anticipating KRAS testing before the onset of metastatic disease in patients at high risk does not affect the sustainability and cost-effectiveness profile of cetuximab in first-line mCRC. Early KRAS testing may prevent this inequality in high-risk patients, whether they develop metastases, and is a cost-effective strategy. Based on these results, present joined recommendations of Italian societies of Oncology and Pathology should be updated including early KRAS testing. © 2014 Barone et al.

Published
2014

41. Postoperative nomogram for predicting survival after resection for intrahepatic cholangiocarcinoma

Author

Ribero D, Rosso S, Pinna AD, Nuzzo G, Guglielmi A, Aldrighetti L, Leone F, Aglietta M, Giulini SM, Gerunda GE, Tomatis M, Berloco P, Calise F, Opocher E, Gruttadauria S, Torzilli G, Capussotti L, Ribero, D, Rosso, S, Pinna, Ad, Nuzzo, G, Guglielmi, A, Aldrighetti, L, Leone, F, Aglietta, M, Giulini, Sm, Gerunda, Ge, Tomatis, M, Berloco, P, Calise, F, Opocher, E, Gruttadauria, S, Torzilli, G, and Capussotti, L

Published
2013

42. LIVER RESECTION AND RADIOFREQUENCY ABLATION IN THE TREATMENT OF SINGLE SMALL (<= 3 CM) HEPATOCELLULAR CARCINOMA (HCC): LONG TERM EFFECTIVENESS IN A MULTICENTER SERIES

Author

Pompili M, Saviano A, de Matthaeis N, Giuliante F, Ardito F, Federico B, Aldrighetti L, Brunello F, Calise F, Capussotti L, Caturelli E, De Sio I, Fornari F, Giorgio A, Giulini SM, Guglielmi A, Pinna AD, Piscaglia F, Torzilli G, Rapaccini GL, Nuzzo G, Pompili, M, Saviano, A, de Matthaeis, N, Giuliante, F, Ardito, F, Federico, B, Aldrighetti, L, Brunello, F, Calise, F, Capussotti, L, Caturelli, E, De Sio, I, Fornari, F, Giorgio, A, Giulini, Sm, Guglielmi, A, Pinna, Ad, Piscaglia, F, Torzilli, G, Rapaccini, Gl, and Nuzzo, G

Published
2012

43. Improvement in perioperative and long-term outcome after surgical treatment of hilar cholangiocarcinoma: results of an Italian multicenter analysis of 440 patients

Author

Nuzzo G, Giuliante F, Ardito F, Giovannini I, Aldrighetti L, Belli G, Bresadola F, Calise F, Dalla Valle R, D'Amico DF, Gennari L, Giulini SM, Guglielmi A, Jovine E, Pellicci R, Pernthaler H, Pinna AD, Puleo S, Torzilli G, Capussotti L, Italian Chapter of the International Hepato-Pancreato-Biliary Association, Cillo U, Ercolani G, Ferrucci M, Mastrangelo L, Portolani N, Pulitanò C, Ribero D, Ruzzenente A, Scuderi V, Federico B, Nuzzo, Gennaro, Giuliante, Felice, Ardito, Francesco, Giovannini, Ivo, Aldrighetti, Luca, Belli, Giulio, Bresadola, Fabrizio, Calise, Fulvio, Dalla Valle, Raffaele, D'Amico, Davide F., Gennari, Leandro, Giulini, Stefano M., Guglielmi, Alfredo, Jovine, Elio, Pellicci, Riccardo, Pernthaler, Heinrich, Pinna, Antonio D., Puleo, Stefano, Torzilli, Guido, Capussotti, Lorenzo, Cillo, Umberto, Ercolani, Giorgio, Ferrucci, Massimo, Mastrangelo, Laura, Portolani, Nazario, Pulitanò, Carlo, Ribero, Dario, Ruzzenente, Andrea, Scuderi, Vincenzo, Federico, Bruno, Nuzzo, G, Giuliante, F, Ardito, F, Giovannini, I, Aldrighetti, L, Belli, G, Bresadola, F, Calise, F, Dalla Valle, R, D'Amico, Df, Gennari, L, Giulini, Sm, Guglielmi, A, Jovine, E, Pellicci, R, Pernthaler, H, Pinna, Ad, Puleo, S, Torzilli, G, and Capussotti, L

Subjects
Male, Blood transfusion, Time Factors, medicine.medical_treatment, Settore MED/18 - CHIRURGIA GENERALE, Adult Aged Aged, Cholangiocarcinoma, Klatskin tumor, Retrospective Studie, 80 and over, Improved results, Main biliary confluence excision, Intrahepatic Cholangiocarcinoma, Outcome, Intrahepatic, Aged, 80 and over, Liver resection, 80 and over Bile Duct Neoplasms/surgery* Bile Ducts, Intrahepatic* Cholangiocarcinoma/surgery* Female Humans Italy Male Middle Aged Retrospective Studies Time Factors Treatment Outcome, Jaundice, Middle Aged, Treatment Outcome, Italy, Female, medicine.symptom, Human, Adult, medicine.medical_specialty, Time Factor, Preoperative care, medicine, Humans, Results, Bile Duct Neoplasm, Adult, Aged, Aged, 80 and over, Bile Duct Neoplasms, surgery, Bile Ducts, Intrahepatic, Cholangiocarcinoma, surgery, Female, Humans, Italy, Male, Middle Aged, Retrospective Studies, Time Factors, Treatment Outcome, Retrospective Studies, Aged, business.industry, Retrospective cohort study, Perioperative, Hilar cholangiocarcinoma, medicine.disease, Surgery, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, Bile Ducts, Hepatectomy, business
Abstract

Objective: To evaluate improvements in operative and long-term results following surgery for hilar cholangiocarcinoma. Design: Retrospective multicenter study including 17 Italian hepatobiliary surgery units. Patients: A total of 440 patients who underwent resection for hilar cholangiocarcinoma from January 1, 1992, through December 31, 2007. Main Outcome Measures: Postoperative mortality, morbidity, overall survival, and disease-free survival. Results: Postoperative mortality and morbidity after liver resection were 10.1% and 47.6%, respectively. At multivariate logistic regression, extent of resection (rightor right extended hepatectomy) and intraoperative blood transfusion were independent predictors of postoperative mortality (P =. 03 and P =. 006, respectively); in patients with jaundice, mortality was also higher without preoperative biliary drainage than with biliary drainage (14.3% vs 10.7%). During the study period, there was an increasingly aggressive approach, with more frequent caudate lobectomies, vascular resections, and resections for advanced tumors (T stage of 3 or greater and tumors with poor differentiation). Despite the aggressive approach, the blood transfusion rate decreased from 81.0% to 53.2%, and mortality slightly decreased from 13.6% to 10.8%. Median overall survival significantly increased from 16 to 30 months (P =. 05). At multivariate analysis, R1 resection, lymph node metastases, and T stage of 3 or greater independently predicted overall and disease-free survival. Conclusions: Surgery for hilar cholangiocarcinoma has improved with decreased operative risk despite a more aggressive surgical policy. Long-term survival after liver resection has also increased, despite the inclusion of cases with more advanced hilar cholangiocarcinoma. Preoperative biliary drainage was a safe strategy before right or right extended hepatectomy in patients with jaundice. Pathologic factors independently predicted overall and disease-free survival at multivariate analysis. Arch Surg. 2012; 147(1): 26-34

Published
2012
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44. Efficacy of an Absorbable Fibrin Sealant Patch (TachoSil) After Distal Pancreatectomy: A Multicenter, Randomized, Controlled Trial

Author

Montorsi, M, Zerbi, A, Bassi, C, Capussotti, L, Coppola, R, Sacchi, M, the Italian Tachosil Study Group, Sperti, Cosimo, Montorsi M, Zerbi A, Bassi C, Capussotti L, Coppola R, Sacchi M, and Casadei R in Italian Tachosil Study Group.

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Fistula, Settore MED/18 - CHIRURGIA GENERALE, law.invention, Pancreatic Fistula, Pancreatectomy, Postoperative Complications, Randomized controlled trial, law, Absorbable Implants, Medicine, Humans, distal pancreatectomy, Prospective Studies, Prospective cohort study, Chi-Square Distribution, business.industry, absorbable fibrin sealant patch, Incidence, Suture Techniques, Thrombin, Fibrinogen, TachoSil, Length of Stay, Middle Aged, medicine.disease, absorbable fibrin sealant patch, distal pancreatectomy, postoperative pancreatic fistula, Surgery, Drug Combinations, Italy, Pancreatic fistula, Anesthesia, Drainage, Female, business, Absorbable Fibrin Sealant Patch, Complication, postoperative pancreatic fistula
Abstract

OBJECTIVE: To evaluate the role of an absorbable fibrin sealant patch (TachoSil) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). BACKGROUND: POPF remains the main complication after DP. METHODS: This was a prospective, open, randomized, study in which patients undergoing elective DP were randomized to standard surgical suturing or stapling with or without TachoSil. The primary end point was the incidence of POPF according to International Study Group on Pancreatic Fistula criteria. Amylase level in drainage fluid, number of days until removal of drain, and duration of hospital stay were secondary end points. RESULTS: A total of 275 patients were enrolled at 19 centers over a 2-year period (TachoSil, n = 145; standard, n = 130). Twenty percent of procedures were laparoscopic and 21% were spleen-preserving resections. The incidence of POPF was not significantly different between groups (TachoSil, 62%; standard 68%; P = 0.267). Grade A fistula rate was similar in both groups (TachoSil 54%; standard 55%), whereas the grade B + C fistula rate was 8% with TachoSil versus 14% without (P = 0.139). Amylase drainage level on postoperative day 1 was significantly reduced with TachoSil (P = 0.025). Median number of days until drainage removal and length of hospital stay were similar in both groups (7 and 10 days, respectively). CONCLUSIONS: The POPF rate was higher than expected when International Study Group on Pancreatic Fistula criteria were strictly applied, although the majority were biochemical fistulas. TachoSil had no significant effect on the rate of POPF, although there was a significant reduction of amylase level in drainage fluid on postoperative day 1.

Published
2012

45. Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC: Results of the European multicenter study of the French Surgical Association

Author

Ouaissi, M., Kianmanesh, R., Ragot, E., Belghiti, J., Wildhaber, B., Nuzzo, Gennaro, Dubois, R., Revillon, Y., Cherqui, D., Azoulay, D., Letoublon, C., Pruvot, F. -R., Roux, A., Mabrut, J. -Y., Gigot, J. -F., De Goyet, J. D. V., Hubert, C., Lerut, J., Otte, J. -B., Reding, R., Farges, O., Sauvanet, A., Wassila, O., Giulante, F., Ardito, Francesco, De Rose Agostino, M., Gelas, T., Mure, P. -Y., Baulieux, J., Gouillat, C., Ducerf, C., Irtan, S., Sarnacki, S., Laurent, A., Compagnon, P., Salloum, C., Lebeau, R., Risse, O., Truant, S., Boleslawski, E., Corfiotti, F., Rat, P., Doussot, A., Ortega-Deballon, P., Paye, F., Balladur, P., Adham, M., Partensky, C., Alhassane, T., Boudjema, K., Dane, C. T., Le Treut, Y. -P., Rinaudo, Marco, Hardwigsen, J., Martelli, H., Gauthier, F., Branchereau, S., Msika, S., Sommacale, D., Palot, J. -P., Ayav, A., Laurain, C. -A., Falconi, M., Castaing, D., Ciacio, O., Adam, R., Vibert, E., Troisi, R., Vanlander, A., Geiss, S., De Taffin, G., Collet, D., Sa Cunha, A., Duguet, L., Chafik, B., Bentabak, K., Graba, A., Meurisse, N., Pirenne, J., Capussotti, L., Langelle, S., Halkic, N., Demartines, N., Cristaudi, A., Molle, G., Mansvelt, B., Saviano, M., Roberta, G., Baraket, O., Bouchoucha, S., Sastre, B., Nuzzo G., Ardito F. (ORCID:0000-0003-1596-2862), Rinaudo M. (ORCID:0000-0002-6130-7335), Ouaissi, M., Kianmanesh, R., Ragot, E., Belghiti, J., Wildhaber, B., Nuzzo, Gennaro, Dubois, R., Revillon, Y., Cherqui, D., Azoulay, D., Letoublon, C., Pruvot, F. -R., Roux, A., Mabrut, J. -Y., Gigot, J. -F., De Goyet, J. D. V., Hubert, C., Lerut, J., Otte, J. -B., Reding, R., Farges, O., Sauvanet, A., Wassila, O., Giulante, F., Ardito, Francesco, De Rose Agostino, M., Gelas, T., Mure, P. -Y., Baulieux, J., Gouillat, C., Ducerf, C., Irtan, S., Sarnacki, S., Laurent, A., Compagnon, P., Salloum, C., Lebeau, R., Risse, O., Truant, S., Boleslawski, E., Corfiotti, F., Rat, P., Doussot, A., Ortega-Deballon, P., Paye, F., Balladur, P., Adham, M., Partensky, C., Alhassane, T., Boudjema, K., Dane, C. T., Le Treut, Y. -P., Rinaudo, Marco, Hardwigsen, J., Martelli, H., Gauthier, F., Branchereau, S., Msika, S., Sommacale, D., Palot, J. -P., Ayav, A., Laurain, C. -A., Falconi, M., Castaing, D., Ciacio, O., Adam, R., Vibert, E., Troisi, R., Vanlander, A., Geiss, S., De Taffin, G., Collet, D., Sa Cunha, A., Duguet, L., Chafik, B., Bentabak, K., Graba, A., Meurisse, N., Pirenne, J., Capussotti, L., Langelle, S., Halkic, N., Demartines, N., Cristaudi, A., Molle, G., Mansvelt, B., Saviano, M., Roberta, G., Baraket, O., Bouchoucha, S., Sastre, B., Nuzzo G., Ardito F. (ORCID:0000-0003-1596-2862), and Rinaudo M. (ORCID:0000-0002-6130-7335)

Abstract

Aim To compare clinical presentation, operative management and short- and long-term outcomes of congenital bile duct cysts (BDC) in adults with children. Methods Retrospective multi-institutional Association Francaise de Chirurgie study of Todani types I+IVB and IVA BDC. Results During the 37-year period to 2011, 33 centers included 314 patients (98 children; 216 adults). The adult population included more high-risk patients, with more active, more frequent prior treatment (47.7% vs 11.2%; p < 0.0001), more complicated presentation (50.5% vs 35.7%; p = 0.015), more synchronous biliary cancer (11.6% vs 0%; p = 0.0118) and more major surgery (23.6% vs 2%; p < 0.0001), but this latter feature was only true for type I+IVB BDC. Compared to children, the postoperative morbidity (48.1% vs 20.4%; p < 0.0001), the need for repeat procedures and the status at follow-up were worse in adults (27% vs 8.8%; p = 0.0009). However, severe postoperative morbidity and fair or poor status at follow-up were not statistically different for type IVA BDC, irrespective of patients' age. Synchronous cancer, prior HBP surgery and Todani type IVA BDC were independent predictive factors of poor or fair long-term outcome. Conclusion BDC is a more indolent disease in children compared to adults, except for Todani type IV-A BDC.

Published
2016

46. Liver resection in patients with eight or more colorectal liver metastases

Author

Viganò L., Capussotti L., Majno P., Toso C., Ferrero A., De Rosa G., Rubbia-Brandt L., and Mentha G.

Subjects
Adult, Male, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Neoplasm Recurrence, Local/etiology, Disease, ddc:616.07, Preoperative care, Gastroenterology, Resection, Liver Neoplasms/secondary/surgery, Internal medicine, medicine, Hepatectomy, Humans, Aged, Aged, 80 and over, Chemotherapy, ddc:617, business.industry, Mortality rate, Liver Neoplasms, Perioperative, Middle Aged, medicine.disease, Chemotherapy regimen, 3. Good health, Surgery, Treatment Outcome, Female, Neoplasm Recurrence, Local, Hepatectomy/methods, business, Colorectal Neoplasms, Epidemiologic Methods
Abstract

Background Patients with large numbers of colorectal liver metastases (CRLMs) are potential candidates for resection, but the benefit from surgery is unclear. Methods Patients undergoing resection for CRLMs between 1998 and 2012 in two high-volume liver surgery centres were categorized according to the number of CRLMs: between one and seven (group 1) and eight or more (group 2). Overall (OS) and recurrence-free (RFS) survival were compared between the groups. Multivariable analysis was performed to identify adverse prognostic factors. Results A total of 849 patients were analysed: 743 in group 1 and 106 in group 2. The perioperative mortality rate (90 days) was 0·4 per cent (all group 1). Median follow-up was 37·4 months. Group 1 had higher 5-year OS (44·2 versus 20·1 per cent; P < 0·001) and RFS (28·7 versus 13·6 per cent; P < 0·001) rates. OS and RFS in group 2 were similar for patients with eight to ten, 11–15 or more than 15 metastases (48, 40 and 18 patients respectively). In group 2, multivariable analysis identified three preoperative adverse prognostic factors: extrahepatic disease (P = 0·010), no response to chemotherapy (P = 0·023) and primary rectal cancer (P = 0·039). Patients with two or more risk factors had very poor outcomes (median OS and RFS 16·9 and 2·5 months; 5-year OS zero); patients in group 2 with no risk factors had similar survival to those in group 1 (5-year OS rate 44 versus 44·2 per cent). Conclusion Liver resection is safe in selected patients with eight or more metastases, and offers reasonable 5-year survival independent of the number of metastases. However, eight or more metastases combined with at least two adverse prognostic factors is associated with very poor survival, and surgery may not be beneficial.

Published
2013

47. Distal pancreatectomy in Italy: Results of a mulcenter survey

Author

Balzano, G., Pecorelli, N., Butturini, G., Boggi, U., Casadei, R., Zerbi, A., Falconi, M., Jovine, E., Capussotti, L., Coppola, R., Veneroni, L., Pasquali, Claudio, Pietrabissa, A., Intini, S., Filauro, M., Mezzatesta, P., Gerunda, G. E., Fronda, G. R., Di Sebastiano, P., Doglietto, G. B., Melotti, G., and Pezzilli, R.

Published
2013

48. A complex of α6 integrin and E-cadherin drives the liver metastasis of colorectal cancer cells by a physical and functional interaction with hepatic angiopoietin-like 6

Author

Marchio', Serena, Soster, Marco, Cardaci S, S., Muratore, A, Bartolini, A, Barone, V, Ribero, D, Monti, M, Bovino, P, Sun, J, Giavazzi, R, Asioli, Sofia, Cassoni, Paola, Capussotti, L, Pucci, P, Bugatti, A, Rusnati, M, Pasqualini, R, Arap, W, and Bussolino, Federico

Subjects
α6 integrin/angptl6/E-cadherin/metastatic colon cancer/phage display/tumor microenvironment
Published
2012

50. Chirurgia Italiana

Author

Basile, Francesco and Capussotti, L.

Subjects
Publishing, Italy, General Surgery, Periodicals as Topic, Societies, Medical
Published
2010

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