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1. Antimicrobial Susceptibility Profiles of Klebsiella pneumoniae Strains Collected from Clinical Samples in a Hospital in Southern Italy

Author

Santella, Biagio, primary, Boccella, Mariarosaria, additional, Folliero, Veronica, additional, Iervolino, Domenico, additional, Pagliano, Pasquale, additional, Fortino, Luigi, additional, Serio, Bianca, additional, Vozzella, Emilia Anna, additional, Schiavo, Luigi, additional, Galdiero, Massimiliano, additional, Capunzo, Mario, additional, Boccia, Giovanni, additional, and Franci, Gianluigi, additional

Published
2024
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5. An emerging role for BAG3 in gynaecological malignancies

Author

De Marco, Margot, Falco, Antonia, Iaccarino, Roberta, Raffone, Antonio, Mollo, Antonio, Guida, Maurizio, Rosati, Alessandra, Chetta, Massimiliano, Genovese, Giovanni, De Caro, Francesco, Capunzo, Mario, Turco, Maria Caterina, Uversky, Vladimir N., and Marzullo, Liberato

Published
2021
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7. Anti-Herpes Zoster Vaccination of Fragile Patients in Hospital Setting: A Nudge Intervention in Italy.

Author

De Caro, Francesco, Malatesta, Francesca, Pecoraro, Nadia, Capunzo, Mario, Carpinelli, Luna, Caruccio, Simona, Cersosimo, Giuseppina, Costantino, Maria, Giordano, Claudio, Longanella, Walter, Patella, Vincenzo, Saggese Tozzi, Arcangelo, Savarese, Giulia, Sinopoli, Pio, Vozzella, Emilia Anna, and Moccia, Giuseppina

Subjects
HERPES zoster, HOSPITAL patients, VACCINATION, PHYSICIAN-patient relations, HERPES zoster vaccines
Abstract

Background: A nudge intervention against Herpes Zoster, created and implemented in Italy, is presented in order to administer the Shingrix vaccine on a sample of frail patients, as required by the National Prevention Plan. Individual and contextual factors associated with vaccine adherence were investigated. Method: 300 frail adult subjects underwent a full vaccine cycle with recombinant-Shingrix vaccine (RZV vaccine). Hospital Presidia of the Salerno University Hospital Authority, a Hospital Presidium of the Salerno Local Health Authority, and the Public Health Laboratory of the University of Salerno (Campania) participated in the intervention. An ad hoc questionnaire was administered with the following scales: EQ-5D, PSS-10, MSPSS, and representations of HZ and its consequences. Results: Some variables, such as peer support, doctor–patient relationship, level of education, and perception of health, are important in vaccine adherence and information processing. The following factors emerged from the factor analysis: Trust in collective knowledge and collective responsibility (F1); beliefs about virus risk and vaccine function (F2); information about virus and symptomatology (F3); and vaccine distrust (F4). Factor 4 correlates negatively with social support indices (R = −0.363; p < 0.001). There is a significant relationship between factor 3 and satisfaction with national information campaigns (F = 3.376; gdl = 5; p-value = 0.006). Conclusions: Future vaccination campaigns should be built with the aim of personalizing information and developing contextualized strategies, starting from understanding the stakeholders involved, cultural contexts, and organizational settings. [ABSTRACT FROM AUTHOR]

Published
2024
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8. An epidemiological qualitative/quantitative SWOT‐AHP analysis in order to highlight the positive or critical aspects of dental implants: A pilot study.

Author

Aliberti, Silvana Mirella, Funk, Richard H. W., De Stefano, Marco, Hoffmann, Thomas, and Capunzo, Mario

Subjects
DENTAL implants, OLDER people, SINUS augmentation, PILOT projects, CHEMICAL resistance, SMOKING
Abstract

Objectives: In recent years, dental implants are increasing in popularity due to their high success rate, demonstrated functionality, and aesthetic treatment results. Scientific research is very active in proposing improvements in the quality and survival of implants, taking into consideration various aspects. The objective of this study was to provide a holistic epidemiologic view of the state of dental implants, using a systematic approach based on a multimethod SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis and AHP (analytical hierarchical process) qualitative–quantitative analysis to identify the characteristics that can determine their success or failure. Materials and Methods: The study used the hybrid method of SWOT‐AHP. Results: Analysis of the results showed that among strengths, the skill of the dentist was considered the most important factor, followed by the success of dental implants in the old people; among weaknesses, bruxism and chronic diseases were highlighted; for opportunities, biomechanical behavior, in terms of good mechanical strength and good tribological resistance to chemical and physical agents in the oral cavity, were considered the most important factors; finally, among threats, medical liability and biomechanical problems had equal weight. Conclusions: This study applied a multimethod SWOT‐AHP approach to bring out favorable or critical evidence on the topic of dental implants. In accordance with the result of the strategic vector identified in the Twisting zone Adjustment type section, showed that implant surgery is a widespread technique but always needs improvement to increase the likelihood of success and reduce the complications that can lead to implant failure. What is known?: Many factors like aging, common diseases, and biomechanical issues early account for the implant success.Sinus floor elevation combined with conventional length implants results in increased cost and treatment time, risk of infection, postoperative sinusitis, limited bone gain.Shorter implants can result in increased biomechanical complications, including loosening and breakage of the implant screw and prosthesis, bone loss.Both procedures include short‐term failures due to overheating of the bone during preparation of the implant site, lack of primary stability due to over‐preparation or poor bone quality, overloading, and others.Bone loss due to peri‐implantitis or implant fractures are the main causes of long‐term implant failure.General implant survival is influenced by tobacco smoking, periodontal disease, systemic disease, bone atrophy, and related factors. What this study adds?: Because the interplay or more parameters can lead to lower implant success, we introduce here a novel calculation method for these factors to provide a holistic epidemiological view of the status of dental implants, adopting a systematic approach based on:a multimethod qualitative–quantitative analysis of strengths, weaknesses, opportunities, and threats (SWOT) andanalytical hierarchical process (AHP) to bring out the favorable or critical aspects and define a possible strategy for action. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Anti-cancer and Anti-angiogenic Effects of Curcumin and Epigallocathechin-3-Gallate in a Mouse Model of Renal Cancer

Author

Barbieri, Antonio, primary, Aliberti, Silvana Mirella, additional, Barretta, Maria Luisa, additional, Picone, Carmine, additional, Luciano, Antonio, additional, Barbieri, Massimiliano, additional, Scognamillo, Giosuè, additional, Santonastaso, Clemente, additional, Alfieri, Tiziana, additional, Sarnicola, Fatima, additional, Petrillo, Antonella, additional, Cianciola, Emidio, additional, Funk, Richard H. W., additional, Capunzo, Mario, additional, and Giudice, Aldo, additional

Published
2023
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10. BAG3 interacts with p53 in endometrial carcinoma

Author

De Marco, Margot, Troisi, Jacopo, Giugliano, Luigi, Rosati, Alessandra, D’Antonio, Antonio, Iaccarino, Roberta, Capunzo, Mario, Salzano, Francesco, Martinelli, Rosanna, Cavallo, Pierpaolo, Guida, Maurizio, and Marzullo, Liberato

Published
2020
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11. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

Author

Rosati, Alessandra, Basile, Anna, D'Auria, Raffaella, d'Avenia, Morena, De Marco, Margot, Falco, Antonia, Festa, Michelina, Guerriero, Luana, Iorio, Vittoria, Parente, Roberto, Pascale, Maria, Marzullo, Liberato, Franco, Renato, Arra, Claudio, Barbieri, Antonio, Rea, Domenica, Menichini, Giulio, Hahne, Michael, Bijlsma, Maarten, Barcaroli, Daniela, Sala, Gianluca, di Mola, Fabio Francesco, di Sebastiano, Pierluigi, Todoric, Jelena, Antonucci, Laura, Corvest, Vincent, Jawhari, Anass, Firpo, Matthew A, Tuveson, David A, Capunzo, Mario, Karin, Michael, De Laurenzi, Vincenzo, and Turco, Maria Caterina

Subjects
Macrophages, Stromal Cells, Animals, Mice, Inbred C57BL, Humans, Mice, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Adaptor Proteins, Signal Transducing, Membrane Proteins, Cell Proliferation, Female, Apoptosis Regulatory Proteins, Phosphatidylinositol 3-Kinases, Inbred C57BL, Carcinoma, Pancreatic Ductal, Adaptor Proteins, Signal Transducing
Abstract

The incidence and death rate of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years, therefore the identification of novel targets for treatment is extremely important. Interactions between cancer and stromal cells are critically involved in tumour formation and development of metastasis. Here we report that PDAC cells secrete BAG3, which binds and activates macrophages, inducing their activation and the secretion of PDAC supporting factors. We also identify IFITM-2 as a BAG3 receptor and show that it signals through PI3K and the p38 MAPK pathways. Finally, we show that the use of an anti-BAG3 antibody results in reduced tumour growth and prevents metastasis formation in three different mouse models. In conclusion, we identify a paracrine loop involved in PDAC growth and metastatic spreading, and show that an anti-BAG3 antibody has therapeutic potential.

Published
2015

14. Antimicrobial Resistance in Pseudomonas aeruginosa before and during the COVID-19 Pandemic

Author

Serretiello, Enrica, primary, Manente, Roberta, additional, Dell’Annunziata, Federica, additional, Folliero, Veronica, additional, Iervolino, Domenico, additional, Casolaro, Vincenzo, additional, Perrella, Alessandro, additional, Santoro, Emanuela, additional, Galdiero, Massimiliano, additional, Capunzo, Mario, additional, Franci, Gianluigi, additional, and Boccia, Giovanni, additional

Published
2023
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17. Antibiotic use and surgical site infections: A single-center retrospective study

Author

Fortino, Luigi, primary, Santella, Biagio, additional, Caro, Francesco, additional, Franci, Gianluigi, additional, Chiara, Anna, additional, Fornino, Domenico, additional, Giordano, Claudio, additional, Giorgio, Riccardo, additional, Palombo, Elisa, additional, Pecora, Domenico, additional, Perillo, Matilde, additional, Santoro, Emanuela, additional, Longanella, Walter, additional, Capunzo, Mario, additional, and Boccia, Giovanni, additional

Published
2023
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18. Alert Microorganisms Procedure: Surveillance, Monitoring And Prevention Of Health Care Associated Infections

Author

Giorgio, Riccardo, primary, Perillo, Matilde, additional, Santella, Biagio, additional, Cioffi, Grazia, additional, De Caro, Francesco, additional, Franci, Gianluigi, additional, De Chiara, Anna, additional, Fornino, Domenico, additional, Fortino, Luigi, additional, Giordano, Claudio, additional, Palombo, Elisa, additional, Pecora, Domenico, additional, Santoro, Emanuela, additional, Tremiterra, Giuliana, additional, Capunzo, Mario, additional, and Boccia, Giovanni, additional

Published
2023
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19. Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent Mechanism

Author

Carrizzo, Albino, Conte, Giulio Maria, Sommella, Eduardo, Damato, Antonio, Ambrosio, Mariateresa, Sala, Marina, Scala, Maria Carmina, Aquino, Rita Patrizia, De Lucia, Massimiliano, Madonna, Michele, Sansone, Francesca, Ostacolo, Carmine, Capunzo, Mario, Migliarino, Serena, Sciarretta, Sebastiano, Frati, Giacomo, Campiglia, Pietro, and Vecchione, Carmine

Published
2018
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22. A LC-MS/MS based methodology for the environmental monitoring of healthcare settings contaminated with antineoplastic agents

Author

Charlier, Bruno, primary, Coglianese, Albino, additional, De Rosa, Federica, additional, Cozzolino, Armando, additional, Boccia, Giovanni, additional, Borrelli, Anna, additional, Capunzo, Mario, additional, Genovese, Giovanni, additional, De Caro, Francesco, additional, Filippelli, Amelia, additional, Dal Piaz, Fabrizio, additional, and Izzo, Viviana, additional

Published
2023
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24. Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease

Author

Laperuta Paolo, Napolitano Filomena, Di Crescenzo Rosa Maria, Zeppa Pio, Galderisi Antonio, Selleri Carmine, Vatrella Alessandro, Capunzo Mario, and Di Crescenzo Vincenzo Giuseppe

Subjects
panniculitis, thoracoscopy, exploratory excision, weber-christian disease, Medicine
Abstract

A 82-year-old patient with dyspnea and a recurrent history of pleural effusion was admitted into our unit. He performed a Chest computed tomography showing right pleural effusion. Video-assisted thoracoscopy (VATS) exploratory showed parietal pleural thickening of adipose tissue. The surgical procedure consisted, therefore, in the execution of multiple biopsies of the parietal pleura which appeared covered, on the whole surface, by islands of adipose tissue, without macroscopic pathological aspects. After the procedure was performed pleurodesis with talc. The definitive histological examination consisted of normal mesothelial cells surrounded by fatty tissue infiltrated by small lymphocytes in a patient without skin lesions or visceral or systemic signs of inflammatory involvement of the adipose tissue. We reported a rare case of idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease.

Published
2016
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25. A Brief Report Monitoring the Different Emotional States As-sociated with the First and the Fourth Dose of the An-ti-SARS-Cov-2 Vaccine in an Italian Sample of Fragile Patients Aged Over 60 Years

Author

Moccia, Giuseppina, primary, Caro, Francesco De, additional, Savarese, Giulia, additional, Chiara, Anna De, additional, Giordano, Claudio, additional, Perillo, Matilde, additional, Fornino, Domenico, additional, Capunzo, Mario, additional, and Carpinelli, Luna, additional

Published
2022
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27. Perceived stress, coping strategies and emotions pre- and post-COVID-19 vaccination in university healthcare students

Author

Savarese, Giulia, Carpinelli, Luna, De Caro, Francesco, Oro, Rosa, Calabrese, Maria Consiglia, Pacifico, Antonietta, Santoro, Emanuela, Boccia, Giovanni, Motta, Oriana, Capunzo, Mario, and Moccia, Giuseppina

Abstract

Background As a consequence of the impact of the COVID-19 pandemic, many studies have identified differences in attitude towards vaccination by university students. The aim of the present study was to investigate various psychological, emotional and behavioral responses influenced by the administration of the COVID-19 vaccine in a sample of university students in healthcare professions. Method An ad hoc questionnaire was created and made available through the Google Modules platform. The questionnaire consisted of the following: a) the Perceived Stress Scale (PSS-10) measuring the degree to which situations in a person's life can be evaluated as stressful, unpredictable, uncontrollable or overloaded; b) the Brief Coping Orientation to the Problems Experienced (Brief COPE) inventory to measure effective and ineffective ways of coping with a stressful life event; and c) seven questions created ad hoc that investigated emotions and moods pre- and post-vaccination. Participants A total of 344 students from the following faculties participated in the study: medicine and surgery (37.5%), nursing (32.8%), obstetrics (15.4%) and physiotherapy (14.2%) at the University of Salerno, Italy. Results In relation to the time of vaccination, 56.7% of the sample showed a moderate level of stress. Many students used emotion-focused and avoidant coping. Females were found to have implemented avoidance strategies more often than males. Conclusions In the pre-vaccination analysis, it is interesting to note that "fear" was the emotion most experienced by the students, as this is the primary emotion characterized by the use of avoidance strategies for survival. Furthermore, the words "hope" and "vaccination" were most often recorded in the post-vaccination phase with correspondingly positive headwords such as: colleague, start, day, result, emotion and able to. This association shows the students' ability to adapt and be resilient through change, and conveys that self-perception is important., Psychology Hub, Vol. 39 No. 2 (2022)

Published
2022
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28. Clinical Status, Nutritional Behavior, and Lifestyle, and Determinants of Community Well-Being of Patients from the Perspective of Physicians: A Cross-Sectional Study of Young Older Adults, Nonagenarians, and Centenarians in Salerno and Province, Italy

Author

Aliberti, Silvana Mirella, primary, Funk, Richard H. W., additional, Schiavo, Luigi, additional, Giudice, Aldo, additional, Ciaglia, Elena, additional, Puca, Annibale Alessandro, additional, Gonnella, Joseph, additional, and Capunzo, Mario, additional

Published
2022
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34. Adverse Events Associated with BNT162b2 and AZD1222 Vaccines in the Real World: Surveillance Report in a Single Italian Vaccine Center

Author

Costantino, Maria, primary, Sellitto, Carmine, additional, Conti, Valeria, additional, Corbi, Graziamaria, additional, Marongiu, Francesco, additional, Genovese, Giovanni, additional, Moccia, Giuseppina, additional, Capunzo, Mario, additional, Borrelli, Anna, additional, Pagliano, Pasquale, additional, Farroni, Mario, additional, Lombardi, Grazia Maria, additional, Elberti, Maria Giovanna, additional, Filippelli, Amelia, additional, and De Caro, Francesco, additional

Published
2022
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35. Gender and AB0 Blood Type Differences in a Unicentric Group of University Professors in Southern Italy Who Received the Vaxzevria COVID-19 Vaccine: A Cross-Sectional Survey of Vaccine Side Effects, Attitudes, and Hesitation

Author

Aliberti, Silvana Mirella, primary, Schiavo, Luigi, additional, Boccia, Giovanni, additional, Santoro, Emanuela, additional, Franci, Gianluigi, additional, Ruggiero, Alessandro, additional, De Caro, Francesco, additional, and Capunzo, Mario, additional

Published
2022
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36. Burnout and Psychological Vulnerability in First Responders: Monitoring Depersonalization and Phobic Anxiety during the COVID-19 Pandemic

Author

Benincasa, Veronica, primary, Passannante, Maria, additional, Perrini, Filippo, additional, Carpinelli, Luna, additional, Moccia, Giuseppina, additional, Marinaci, Tiziana, additional, Capunzo, Mario, additional, Pironti, Concetta, additional, Genovese, Armando, additional, Savarese, Giulia, additional, De Caro, Francesco, additional, and Motta, Oriana, additional

Published
2022
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41. BAG3 induces α‐SMA expression in human fibroblasts and its over‐expression correlates with poorer survival in fibrotic cancer patients

Author

De Marco, Margot, primary, Del Papa, Nicoletta, additional, Reppucci, Francesca, additional, Iorio, Vittoria, additional, Basile, Anna, additional, Falco, Antonia, additional, Iaccarino, Roberta, additional, Brongo, Sergio, additional, De Caro, Francesco, additional, Capunzo, Mario, additional, Turco, Maria Caterina, additional, Rosati, Alessandra, additional, and Marzullo, Liberato, additional

Published
2021
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42. Different mechanisms underlie IL-6 release in chemosensitive and chemoresistant ovarian carcinoma cells

Author

margot de marco, Falco, Antonia, Festa, Michela, Antonio, Raffone, Lucia, Sandullo, Alessandra Rosati, Reppucci, Francesca, Cammarota, Anna Lisa, Franca, Esposito, Danilo Swann Matassa, Pascale, Maria, Salzano F.A., Rosanna Martinelli, Remondelli, Paolo, Capunzo, Mario, Antonio MOLLO, Zullo, Fulvio, Antonio, Travaglino, Maurizio, Guida, Liberato Marzullo, De Marco, Margot, Falco, Antonia, Festa, Michela, Raffone, Antonio, Sandullo, Lucia, Rosati, Alessandra, Reppucci, Francesca, Cammarota, Anna Lisa, Esposito, Franca, Matassa, Danilo Swann, Pascale, Maria, Salzano, Francesco, Martinelli, Rosanna, Remondelli, Paolo, Capunzo, Mario, Mollo, Antonio, Zullo, Fulvio, Travaglino, Antonio, Guida, Maurizio, and Marzullo, Liberato

Subjects
ovarian cancer, Interleukin-6, ovarian benign cysts, chemoresistance, Interleukin-6, ovarian cancer, ovarian benign cysts, chemoresistance, AKT inhibitor, ovarian benign cyst, AKT inhibitor
Abstract

Interleukin (IL)-6 has been detected in serum and ascites from patients affected by epithelial ovarian cancers, and also in some human ovarian cancer cell lines. To investigate the role of IL-6 in ovarian lesions, we first measured its levels in serum samples of 24 healthy donors and in 17 and 9 patients affected by ovarian carcinomas and ovarian benign cysts respectively. IL-6 levels were significantly higher than healthy donors in serum samples from ovarian cancer patients, but not in benign ovarian cysts. We then investigated the mechanism of IL-6 production in two cell lines obtained from the same patient with high grade serous ovarian carcinoma before (PEA1) and after (PEA2) development of cisplatinum resistance. The levels of intracellular IL-6, analysed by western blotting, did not relevantly differ in the two cell lines, and they did not change after the cell treatment with an AKT inhibitor. Although the interleukin was present in supernatants from both cell lines, its concentration in the supernatant of chemoresistant cells was significantly higher than chemosensitive cells. Interestingly, exposure to the AKT inhibitor resulted in a reduced IL-6 release in PEA1, but not in PEA2 cells. These results let infer different mechanisms of IL-6 release in chemoresistant and chemosensitive cell lines, and contribute new insights in ovarian cancer biology that suggest more in depth studies about the role of AKT in IL-6 release and in development of chemoresistance.

Published
2020

45. Trend of Bacterial Uropathogens and Their Susceptibility Pattern: Study of Single Academic High-Volume Center in Italy (2015–2019)

Author

Serretiello, Enrica, primary, Folliero, Veronica, additional, Santella, Biagio, additional, Giordano, Giuseppina, additional, Santoro, E., additional, De Caro, Francesco, additional, Pagliano, Pasquale, additional, Ferro, Matteo, additional, Aliberti, Silvana M., additional, Capunzo, Mario, additional, Galdiero, Massimiliano, additional, Franci, Gianluigi, additional, and Boccia, Giovanni, additional

Published
2021
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48. Environmental and Biological Monitoring of Formaldehyde inside A Hospital Setting: A Combined Approach to Manage Chemical Risk in Workplaces

Author

Motta, Oriana, primary, Charlier, Bruno, additional, De Caro, Francesco, additional, Coglianese, Albino, additional, Rosa, Federica, additional, Moccia, Giuseppina, additional, Pironti, Concetta, additional, Capunzo, Mario, additional, Borrelli, Anna, additional, Filippelli, Amelia, additional, and Izzo, Viviana, additional

Published
2021
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50. HUMAN BIO-MONITORING AND BIO-INDICATORS FOR HEALTH RISK MANAGEMENT ASSOCIATED TO CHRONIC EXPOSURES IN HIGH RADON CONCENTRATION ENVIRONMENTS: A REVIEW

Author

Mancini, Simona, Guida, Michele, Cuomo, Albina, Guida, Domenico, DE MARCO, Margot, Marzullo, Liberato, Rosati, Alessandra, Turco, Maria Caterina, DE CARO, Francesco, Moccia, Giuseppina, Capunzo, Mario, Aliberti, SILVANA MIRELLA, Anna Di Cosmo, Anna Valeria Maselli, Gianluca, Polese, Nataša, Todorović, and Jovana, Nikolov.

Published
2020

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