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2. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, and Valsecchi, Maria Grazia

Published
2023
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7. Ecology, Epidemiology and Human Health Implications of Avian Influenza Viruses: Why do we need to share genetic information?

Author

Capua, Ilaria

Subjects
JE. Record keeping., BG. Information dissemination and diffusion.
Abstract

Avian influenza viruses of the H5N1 subtype have become widespread in vast areas of Asia, the Middle East, Europe and Africa. This opportunity given to the virus has greatly increased its potential to affect the health of wild and domestic animals and humans. Currently, human health is affected both in terms of the reduction of food security and as a result of infection of humans which could be a prelude to the emergence of a new pandemic virus. The medical, veterinary and agricultural scientific communities are challenged with a virus that is moving in a tri-dimensional fashion, modifying itself as it adapts to different species and reassorting with other influenza viruses of avian and potentially mammalian origin, as it infects new species. A significant collaborative and financial effort in a transparent scientific environment are required to generate data and ideas contributing to the eradication effort. Until the extensive circulation of the virus is limited in the domestic avian reservoir, avian influenza will continue to remain an issue for food security and a global threat for animal and human health.

Published
2007

17. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, Valsecchi, Maria Grazia, Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, and Valsecchi, Maria Grazia

Abstract

Background: The prognostic impact of electrolyte disorders in hospitalized COVID-19 patients is unclear. Methods: The study included all adult patients hospitalized for COVID-19 in four hospitals in Northern Italy between January 2020 and May 2021 with at least one serum potassium and sodium measurement performed within 3 days since admission. Primary outcome was in-hospital death; secondary outcome was Intensive Care Unit (ICU) admission. A cause-specific Cox proportional-hazards regression model was used for investigating the association between potassium and sodium (as either categorical or continuous variables) and mortality or admission to ICU. Results: Analyses included 3,418 adult hospitalized COVID-19 patients. At multivariable analysis, both hyperkalemia (Hazard Ratio, [HR] 1.833, 95% Confidence Interval [CI] 1.371–2.450) and sK above the median (K 5.1 vs 4.1 mmol/L: HR 1.523, 95% CI 1.295–1.798), and hypernatremia (HR 2.313, 95%CI 1.772–3.018) and sNa above the median (Na 149 vs 139 mmol/L: HR 1.442, 95% CI 1.234–1.686), were associated with in-hospital death, whereas hypokalemia and hyponatremia were not. Hyponatremia was associated with increased hazard of ICU admission (HR 1.884, 95%CI 1.389–2.556). Conclusions: Electrolyte disorders detected at hospital admission may allow early identification of COVID-19 patients at increased risk of adverse outcomes.

Published
2023

22. The panzootic potential of SARS-CoV-2.

Author

Mabry, Makenzie E, Fanelli, Angela, Mavian, Carla, Lorusso, Alessio, Manes, Costanza, Soltis, Pamela S, and Capua, Ilaria

Subjects
SARS-CoV-2, NUMBERS of species, ANGIOTENSIN converting enzyme
Abstract

Each year, SARS-CoV-2 is infecting an increasingly unprecedented number of species. In the present article, we combine mammalian phylogeny with the genetic characteristics of isolates found in mammals to elaborate on the host-range potential of SARS-CoV-2. Infections in nonhuman mammals mirror those of contemporary viral strains circulating in humans, although, in certain species, extensive viral circulation has led to unique genetic signatures. As in other recent studies, we found that the conservation of the ACE2 receptor cannot be considered the sole major determinant of susceptibility. However, we are able to identify major clades and families as candidates for increased surveillance. On the basis of our findings, we argue that the use of the term panzootic could be a more appropriate term than pandemic to describe the ongoing scenario. This term better captures the magnitude of the SARS-CoV-2 host range and would hopefully inspire inclusive policy actions, including systematic screenings, that could better support the management of this worldwide event. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers

Author

Harris, Kate A., Freidl, Gudrun S., Munoz, Olga S., von Dobschuetz, Sophie, De Nardi, Marco, Wieland, Barbara, Koopmans, Marion P. G., Stärk, Katharina D. C., van Reeth, Kristien, Dauphin, Gwen, Meijer, Adam, de Bruin, Erwin, Capua, Ilaria, Hill, Andy A., Kosmider, Rowena, Banks, Jill, Stevens, Kim, van der Werf, Sylvie, Enouf, Vincent, van der Meulen, Karen, Brown, Ian H., Alexander, Dennis J., Breed, Andrew C., and the FLURISK Consortium

Published
2017
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29. Development of broad‐spectrum human monoclonal antibodies for rabies post‐exposure prophylaxis

Author

De Benedictis, Paola, Minola, Andrea, Rota Nodari, Elena, Aiello, Roberta, Zecchin, Barbara, Salomoni, Angela, Foglierini, Mathilde, Agatic, Gloria, Vanzetta, Fabrizia, Lavenir, Rachel, Lepelletier, Anthony, Bentley, Emma, Weiss, Robin, Cattoli, Giovanni, Capua, Ilaria, Sallusto, Federica, Wright, Edward, Lanzavecchia, Antonio, Bourhy, Hervé, and Corti, Davide

Published
2016
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30. Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review

Author

Munoz, Olga, De Nardi, Marco, van der Meulen, Karen, van Reeth, Kristien, Koopmans, Marion, Harris, Kate, von Dobschuetz, Sophie, Freidl, Gudrun, Meijer, Adam, Breed, Andrew, Hill, Andrew, Kosmider, Rowena, Banks, Jill, Stärk, Katharina D. C., Wieland, Barbara, Stevens, Kim, van der Werf, Sylvie, Enouf, Vincent, Dauphin, Gwenaelle, Dundon, William, Cattoli, Giovanni, Capua, Ilaria, and The FLURISK Consortium

Published
2016
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31. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, Simonetta, primary, Regolisti, Giuseppe, additional, Rebora, Paola, additional, Occhino, Giuseppe, additional, Belli, Michele, additional, Molon, Giulio, additional, Citerio, Giuseppe, additional, Beltrame, Anna, additional, Maloberti, Alessandro, additional, Generali, Elena, additional, Giannattasio, Cristina, additional, Epis, Oscar Massimiliano, additional, Rossetti, Claudio, additional, Bellelli, Giuseppe, additional, De Nalda, Ana Lleo, additional, Capua, Ilaria, additional, and Valsecchi, Maria Grazia, additional

Published
2022
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35. Transmission Studies Resume For Avian Flu

Author

FOUCHIER, RON A. M., GARCÍA-SASTRE, ADOLFO, KAWAOKA, YOSHIHIRO, BARCLAY, WENDY S., BOUVIER, NICOLE M., BROWN, IAN H., CAPUA, ILARIA, CHEN, HUALAN, COMPANS, RICHARD W., COUCH, ROBERT B., COX, NANCY J., DOHERTY, PETER C., DONIS, RUBEN O., FELDMANN, HEINZ, GUAN, YI, KATZ, JACQUELINE M., KISELEV, OLEG I., KLENK, H. D., KOBINGER, GARY, LIU, JINHUA, LIU, XIUFAN, LOWEN, ANICE, METTENLEITER, THOMAS C., OSTERHAUS, ALBERT D. M. E., PALESE, PETER, PEIRIS, J. S. MALIK, PEREZ, DANIEL R., RICHT, JÜRGEN A., SCHULTZ-CHERRY, STACEY, STEEL, JOHN, SUBBARAO, KANTA, SWAYNE, DAVID E., TAKIMOTO, TORU, TASHIRO, MASATO, TAUBENBERGER, JEFFERY K., THOMAS, PAUL G., TRIPP, RALPH A., TUMPEY, TERRENCE M., WEBBY, RICHARD J., and WEBSTER, ROBERT G.

Published
2013
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36. Association between sex hormone levels and clinical outcomes in patients with COVID-19 admitted to hospital: An observational, retrospective, cohort study

Author

Ministero della Salute, Beltrame, Anna, Salguero, Pedro, Rossi, Emanuela, Conesa, Ana, Moro, Lucia, Bettini, Laura Rachele, Rizzi, Eleonora, D’Angió, Mariella, Deiana, Michela, Piubelli, Chiara, Rebora, Paola, Duranti, Silvia, Bonfanti, Paolo, Capua, Ilaria, Tarazona, Sonia, Valsecchi, Maria Grazia, Ministero della Salute, Beltrame, Anna, Salguero, Pedro, Rossi, Emanuela, Conesa, Ana, Moro, Lucia, Bettini, Laura Rachele, Rizzi, Eleonora, D’Angió, Mariella, Deiana, Michela, Piubelli, Chiara, Rebora, Paola, Duranti, Silvia, Bonfanti, Paolo, Capua, Ilaria, Tarazona, Sonia, and Valsecchi, Maria Grazia

Abstract

Understanding the cause of sex disparities in COVID-19 outcomes is a major challenge. We investigate sex hormone levels and their association with outcomes in COVID-19 patients, stratified by sex and age. This observational, retrospective, cohort study included 138 patients aged 18 years or older with COVID-19, hospitalized in Italy between February 1 and May 30, 2020. The association between sex hormones (testosterone, estradiol, progesterone, dehydroepiandrosterone) and outcomes (ARDS, severe COVID-19, in-hospital mortality) was explored in 120 patients aged 50 years and over. STROBE checklist was followed. The median age was 73.5 years [IQR 61, 82]; 55.8% were male. In older males, testosterone was lower if ARDS and severe COVID-19 were reported than if not (3.6 vs. 5.3 nmol/L, p =0.0378 and 3.7 vs. 8.5 nmol/L, p =0.0011, respectively). Deceased males had lower testosterone (2.4 vs. 4.8 nmol/L, p =0.0536) and higher estradiol than survivors (40 vs. 24 pg/mL, p = 0.0006). Testosterone was negatively associated with ARDS (OR 0.849 [95% CI 0.734, 0.982]), severe COVID-19 (OR 0.691 [95% CI 0.546, 0.874]), and in-hospital mortality (OR 0.742 [95% CI 0.566, 0.972]), regardless of potential confounders, though confirmed only in the regression model on males. Higher estradiol was associated with a higher probability of death (OR 1.051 [95% CI 1.018, 1.084]), confirmed in both sex models. In males, higher testosterone seems to be protective against any considered outcome. Higher estradiol was associated with a higher probability of death in both sexes.

Published
2022

37. Pause on Avian Flu Transmission Research

Author

FOUCHIER, RON A. M., GARCÍA-SASTRE, ADOLFO, KAWAOKA, YOSHIHIRO, BARCLAY, WENDY S., BOUVIER, NICOLE M., BROWN, IAN H., CAPUA, ILARIA, CHEN, HUALAN, COMPANS, RICHARD W., COUCH, ROBERT B., COX, NANCY J., DOHERTY, PETER C., DONIS, RUBEN O., FELDMANN, HEINZ, GUAN, Yl, KATZ, JAQUEUNE, KLENK, H. D., KOBINGER, GARY, LIU, JINHUA, LIU, XIUFAN, LOWEN, ANICE, METTENLEITER, THOMAS C., OSTERHAUS, ALBERT D. M. E., PALESE, PETER, PEIRIS, J. S. MALIK, PEREZ, DANIEL R., RICHT, JÜRGEN A., SCHULTZ-CHERRY, STACEY, STEEL, JOHN, SUBBARAO, KANTA, SWAYNE, DAVID E., TAKIMOTO, TORU, TASHIRO, MASATO, TAUBENBERGER, JEFFERY K., THOMAS, PAUL G., TRIPP, RALPH A., TUMPEY, TERRENCE M., WEBBY, RICHARD J., and WEBSTER, ROBERT G.

Published
2012
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40. Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus

Author

Kongkamnerd, Jarinrat, Cappelletti, Luca, Prandi, Adolfo, Seneci, Pierfausto, Rungrotmongkol, Thanyada, Jongaroonngamsang, Nutthapon, Rojsitthisak, Pornchai, Frecer, Vladimir, Milani, Adelaide, Cattoli, Giovanni, Terregino, Calogero, Capua, Ilaria, Beneduce, Luca, Gallotta, Andrea, Pengo, Paolo, Fassina, Giorgio, Miertus, Stanislav, and De-Eknamkul, Wanchai

Published
2012
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41. Genetic data from avian influenza and avian paramyxoviruses generated by the European network of excellence (EPIZONE) between 2006 and 2011—Review and recommendations for surveillance

Author

Dundon, William G., Heidari, Alireza, Fusaro, Alice, Monne, Isabella, Beato, Maria Serena, Cattoli, Giovanni, Koch, Guus, Starick, Elke, Brown, Ian H., Aldous, Elisabeth W., Briand, François-Xavier, Le Gall-Reculé, Ghislaine, Jestin, Véronique, Jørgensen, Poul H., Berg, Mikael, Zohari, Siamak, Metreveli, Giorgi, Munir, Muhammad, Ståhl, Karl, Albina, Emmanuel, Hammoumi, Saliha, Gil, Patricia, Servan de Almeida, Renata, Śmietanka, Krzysztof, Domańska-Blicharz, Katarzyna, Minta, Zenon, Van Borm, Steven, van den Berg, Thierry, Moreno Martin, Ana, Barbieri, Ilaria, and Capua, Ilaria

Published
2012
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50. Association Between Sex Hormone Levels and Clinical Outcomes in Patients With COVID-19 Admitted to Hospital: An Observational, Retrospective, Cohort Study

Author

Beltrame, Anna, primary, Salguero, Pedro, additional, Rossi, Emanuela, additional, Conesa, Ana, additional, Moro, Lucia, additional, Bettini, Laura Rachele, additional, Rizzi, Eleonora, additional, D’Angió, Mariella, additional, Deiana, Michela, additional, Piubelli, Chiara, additional, Rebora, Paola, additional, Duranti, Silvia, additional, Bonfanti, Paolo, additional, Capua, Ilaria, additional, Tarazona, Sonia, additional, and Valsecchi, Maria Grazia, additional

Published
2022
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