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2. Non-response to first-line hormonal treatment for symptomatic endometriosis: overcoming tunnel vision. A narrative review

Author

Cetera, G. E., Merli, C. E. M., Facchin, Federica, Viganò, P., Pesce, E., Caprara, F., Vercellini, P., Facchin F. (ORCID:0000-0001-8944-1440), Cetera, G. E., Merli, C. E. M., Facchin, Federica, Viganò, P., Pesce, E., Caprara, F., Vercellini, P., and Facchin F. (ORCID:0000-0001-8944-1440)

Abstract

One-fourth to one-third of women with endometriosis receiving first-line hormonal treatment lacks an adequate response in terms of resolution of painful symptoms. This phenomenon has been ascribed to "progesterone resistance", an entity that was theorized to explain the gap between the ubiquity of retrograde menstruation and the 10% prevalence of endometriosis among women of reproductive age.Nevertheless, the hypothesis of progesterone resistance is not free of controversies. As our understanding of endometriosis is increasing, authors are starting to set aside the traditionally accepted tunnel vision of endometriosis as a strictly pelvic disease, opening to a more comprehensive perspective of the condition. The question is: are patients not responding to first-line treatment because they have an altered signaling pathway for such treatment, or have we been overlooking a series of other pain contributors which may not be resolved by hormonal therapy?Finding an answer to this question is evermore impelling, for two reasons mainly. Firstly, because not recognizing the presence of further pain contributors adds a delay in treatment to the already existing delay in diagnosis of endometriosis. This may lead to chronicity of the untreated pain contributors as well as causing adverse consequences on quality of life and psychological health. Secondly, misinterpreting the consequences of untreated pain contributors as a non-response to standard first-line treatment may imply the adoption of second-line medical therapies or of surgery, which may entail non-negligible side effects and may not be free of physical, psychological and socioeconomic repercussions.The current narrative review aims at providing an overview of all the possible pain contributors in endometriosis, ranging from those strictly organic to those with a greater neuro-psychological component. Including these aspects in a broader psychobiological approach may provide useful suggestions for treating those patie

Published
2023

4. Risultati della sperimentazione 2015-2016: Le varietà di avena per le prossime semine

Author

Perenzin M., Notario T., Bottazzi P., Cambrea M., Caprara F., Colonna M., Codanni P., Codecà F., Dettori M., Faeti D., Fiorentino S., Fuselli D., Garioni A., Invernizzi C., Marino A., Palumbo M., Petrini A., Poma I., Quaranta F., Randazzo B., Reggiani F., Ricci M., Signor M., Terno A. B., Terzi V., Vecchiarelli V., Viola P., Virdis A., Zanoni G., Perenzin, M., Notario, T., Bottazzi, P., Cambrea, M., Caprara, F., Colonna, M., Codanni, P., Codecà, F., Dettori, M., Faeti, D., Fiorentino, S., Fuselli, D., Garioni, A., Invernizzi, C., Marino, A., Palumbo, M., Petrini, A., Poma, I., Quaranta, F., Randazzo, B., Reggiani, F., Ricci, M., Signor, M., Terno, A., Terzi, V., Vecchiarelli, V., Viola, P., Virdis, A., and Zanoni, G.

Subjects
Caratterizzazione morfo-fisiolocha e quanti-qualitativa di varità di avena, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract

L’annata agraria 2015-2016, caratterizzata da condizioni climatiche abbastanza favorevoli per i cereali autunno-vernini, ha determinato produzioni di granella interessanti in tutta la Penisola, in particolare al Nord. Genziana si conferma la varietà adatta a tutti gli areali.

Published
2017

5. Speciale orzo: produzioni ottime al Nord e buone al Centro-Sud

Author

Bartolozzi, F., Gnudi, G., Cattivelli, L., Faccini, N., Gianinetti, A., Alberici, R., AMATO, Gaetano, Anastasi, U., Attene, G., Baravelli, M., Barbiani G., Baronchelli M., Belocchi A., Bonciarelli U., Cacciatori P., Caprara F., Codianni P., Delbono S., Donadeo G., Faeti, V., Fecondo, G., Fina C., Fornara, M., FRENDA, Alfonso Salvatore, Fuselli, D., Ghizzoni, R., GIAMBALVO, Dario, Giausa, S., Invernizzi, C., Licciardello, S., Lombardo, M. G., Lorenzetti, M. C., Manca, G., Marino, A., Mastrorilli, M., Mazzieri, G., Monti, M., Notario, T., Pagani, D., Palumbo, M., Petrini, A., Pilati, A., Piredda, A., POMA, Ignazio, Pons, R., Preiti, G., Quaranta, F., Randazzo, B., Ravaglia, S., Reggiani, F., Rodriguez, M., Romeo, M., RUISI, Paolo, SARNO, Mauro, Scarcella, M., Sciacca, F., Signor, M., Tagliaferri, I., VENEZIA, Giacomo, Viola, P., Virdis, A., Virgillito, S., Virzì, N., Bartolozzi, F., Gnudi, G., Cattivelli, L. (coord), Faccini, N. (coord), Gianinetti, A. (coord), Alberici, R., Amato, G., Anastasi, U., Attene, G., Baravelli, M., Barbiani G., Baronchelli M., Belocchi A., Bonciarelli U., Cacciatori P., Caprara F., Codianni P., Delbono S., Donadeo G., Faeti, V., Fecondo, G., Fina C., Fornara, M., Frenda, A.S., Fuselli, D., Ghizzoni, R., Giambalvo, D., Giausa, S., Invernizzi, C., Licciardello, S., Lombardo, M.G., Lorenzetti, M.C., Manca, G., Marino, A., Mastrorilli, M., Mazzieri, G., Monti, M., Notario, T., Pagani, D., Palumbo, M., Petrini, A., Pilati, A., Piredda, A., Poma, I., Pons, R., Preiti, G., Quaranta, F., Randazzo, B., Ravaglia, S., Reggiani, F., Rodriguez, M., Romeo, M., Ruisi, P., Sarno, M., Scarcella, M., Sciacca, F., Signor, M., Tagliaferri, I., Venezia, G., Viola, P., Virdis, A., Virgillito, S., and Virzì, N.

Subjects
Rete nazionale, Barley, National varietal evaluation, Valutazione varietale, Orzo zootecnico e da malto, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract

Il clima ha consentito una delle migliori stagioni a livello di rese compensando i prezzi bassi. Seconda stagione consecutiva positiva per gli agricoltori che hanno puntato sull’orzo. La produzione media complessiva al nord (33 varieta’ testate in 8 localita’ diverse) ha raggiunto le 7,6 t/ha; nel centro Italia, le 32 varieta’ testate nelle 6 località hanno registrato una media di 6,7 t/ha; infine, il sud ha registrato una rea media decisamente buona (5 t/ha) e superiore allo scorso anno. Inoltre, quest’anno l’andamento climatico ha reso conveniente fare orzo da birra anche al centro-nord.

Published
2016

6. Le varietà migliori per l’orzo da birra

Author

Cattivelli, L., Faccini, N., Gianinetti, A., Alberici, R., Anastasi, U., Attene, G., Baravelli, M., Barbiani G., Baronchelli M., Belocchi A., Bonciarelli U., Cacciatori P., Caprara F., Codianni P., Delbono S., Donadeo G., Faeti, V., Fecondo, G., Fina C., Fornara, M., Fuselli, D., Ghizzoni, R., Giausa, S., Invernizzi, C., Licciardello, S., Lombardo, M. G., Lorenzetti, M. C., Manca, G., Marino, A., Mastrorilli, M., Mazzieri, G., Monti, M., Notario, T., Pagani, D., Palumbo, M., Petrini, A., Pilati, A., Piredda, A., Pons, R., Preiti, G., Quaranta, F., Randazzo, B., Ravaglia, S., Reggiani, F., Rodriguez, M., Romeo, M., Scarcella, M., Sciacca, F., Signor, M., Tagliaferri, I., Viola, P., Virdis, A., Virgillito, S., Virzì, N., AMATO, Gaetano, FRENDA, Alfonso Salvatore, GIAMBALVO, Dario, POMA, Ignazio, RUISI, Paolo, SARNO, Mauro, VENEZIA, Giacomo, Cattivelli, L. (coord), Faccini, N. (coord), Gianinetti, A. (coord), Alberici, R., Amato, G., Anastasi, U., Attene, G., Baravelli, M., Barbiani G., Baronchelli M., Belocchi A., Bonciarelli U., Cacciatori P., Caprara F., Codianni P., Delbono S., Donadeo G., Faeti, V., Fecondo, G., Fina C., Fornara, M., Frenda, A.S., Fuselli, D., Ghizzoni, R., Giambalvo, D., Giausa, S., Invernizzi, C., Licciardello, S., Lombardo, M.G., Lorenzetti, M.C., Manca, G., Marino, A., Mastrorilli, M., Mazzieri, G., Monti, M., Notario, T., Pagani, D., Palumbo, M., Petrini, A., Pilati, A., Piredda, A., Poma, I., Pons, R., Preiti, G., Quaranta, F., Randazzo, B., Ravaglia, S., Reggiani, F., Rodriguez, M., Romeo, M., Ruisi, P., Sarno, M., Scarcella, M., Sciacca, F., Signor, M., Tagliaferri, I., Venezia, G., Viola, P., Virdis, A., Virgillito, S., and Virzì, N.

Subjects
Malt barley, Valutazione varietale nazionale, National varietal evaluation, Orzo da malto, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract

Il 2016, come già il 2015, è stato un anno assai variegato per le produzioni, ma certamente più favorevole per la coltura dell’orzo primaverile al Centro-Nord rispetto al biennio 2013-2014

Published
2016

7. Annata straordinaria per l’orzo al Nord Italia

Author

Cattivelli, L., Faccini, N., Gianinetti, A., Alberici, R., Anastasi, U., Attene, G., Baravelli, M., Barbiani G., Baronchelli M., Belocchi A., Bonciarelli U., Cacciatori P., Caprara F., Codianni P., Delbono S., Donadeo G., Faeti, V., Fecondo, G., Fina C., Fornara, M., Fuselli, D., Ghizzoni, R., Giausa, S., Invernizzi, C., Licciardello, S., Lombardo, M. G., Lorenzetti, M. C., Manca, G., Marino, A., Mastrorilli, M., Mazzieri, G., Monti, M., Notario, T., Pagani, D., Palumbo, M., Petrini, A., Pilati, A., Piredda, A., Pons, R., Preiti, G., Quaranta, F., Randazzo, B., Ravaglia, S., Reggiani, F., Rodriguez, M., Romeo, M., Scarcella, M., Sciacca, F., Signor, M., Tagliaferri, I., Viola, P., Virdis, A., Virgillito, S., Virzì, N., AMATO, Gaetano, FRENDA, Alfonso Salvatore, GIAMBALVO, Dario, POMA, Ignazio, RUISI, Paolo, SARNO, Mauro, VENEZIA, Giacomo, Cattivelli, L. (coordinatore), Faccini, N. (coordinatore), Gianinetti, A. (coordinatore), Alberici, R., Amato, G., Anastasi, U., Attene, G., Baravelli, M., Barbiani G., Baronchelli M., Belocchi A., Bonciarelli U., Cacciatori P., Caprara F., Codianni P., Delbono S., Donadeo G., Faeti, V., Fecondo, G., Fina C., Fornara, M., Frenda, A.S., Fuselli, D., Ghizzoni, R., Giambalvo, D., Giausa, S., Invernizzi, C., Licciardello, S., Lombardo, M.G., Lorenzetti, M.C., Manca, G., Marino, A., Mastrorilli, M., Mazzieri, G., Monti, M., Notario, T., Pagani, D., Palumbo, M., Petrini, A., Pilati, A., Piredda, A., Poma, I., Pons, R., Preiti, G., Quaranta, F., Randazzo, B., Ravaglia, S., Reggiani, F., Rodriguez, M., Romeo, M., Ruisi, P., Sarno, M., Scarcella, M., Sciacca, F., Signor, M., Tagliaferri, I., Venezia, G., Viola, P., Virdis, A., Virgillito, S., and Virzì, N.

Subjects
Valutazione varietale nazionale, Barley, Orzo, National varietal evaluation, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract

La Rete delle prove nazionali di orzo da zootecnia per l’annata 2015-2016 evidenzia ottimi risultati produttivi soprattutto al Nord Italia. In questo articolo riportiamo la valutazione di 39 varietà ripartite in tre diversi gruppi varietali a seconda dell’areale interessato dalla sperimentazione (Nord, Centro, Sud e Isole)

Published
2016

8. Al centro-nord vince la pioggia, bene solo il Meridione

Author

Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Anastasi, U, Attene, G, Baravelli, M, Barbiani, G, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D’Ercole, M, Delbono, S, Demontis, A, Faeti, V, Fecondo, G, Ferrero, C, Fornara, M, Fuselli, D, Ghizzoni, R, Innocenti, A, Invernizzi, C, Lombardo, MG, Lorenzetti, MC, Manca, G, Marino, A, Mattiolo, E, Mazzieri, G, Monti, M, Notario, T, Pagani, D, Petrini, A, Pilati, A, Piredda, A, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Rosta, R, Scrosati, M, Severi, D, Signor, M, Tagliaferri, I, Tassi, D, Viola, P, Virdis, A, Virgillito, S, Virzì, N., AMATO, Gaetano, FRENDA, Alfonso Salvatore, GIAMBALVO, Dario, POMA, Ignazio, RUISI, Paolo, SAIA, Sergio, SARNO, Mauro, VENEZIA, Giacomo, Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Amato, G, Anastasi, U, Attene, G, Baravelli, M, Barbiani, G, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D’Ercole, M, Delbono, S, Demontis, A, Faeti, V, Fecondo, G, Ferrero, C, Fornara, M, Frenda, AS, Fuselli, D, Ghizzoni, R, Giambalvo, D, Innocenti, A, Invernizzi, C, Lombardo, MG, Lorenzetti, MC, Manca, G, Marino, A, Mattiolo, E, Mazzieri, G, Monti, M, Notario, T, Pagani, D, Petrini, A, Pilati, A, Piredda, A, Poma, I, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Rosta, R, Ruisi, P, Saia, S, Sarno, M, Scrosati, M, Severi, D, Signor, M, Tagliaferri, I, Tassi, D, Venezia, G, Viola, P, Virdis, A, Virgillito, S, and Virzì, N

Subjects
Orzo da malto, Orzo da zootecnia, Varietà, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Published
2014

9. Le varietà per l’orzo da malto

Author

Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Anastasi, U, Attene, G, Baravelli, M, Barbiani, G, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D’Ercole, M, Delbono, S, Demontis, A, Faeti, V, Fecondo, G, Ferrero, C, Fornara, M, Fuselli, D, Ghizzoni, R, Innocenti, A, Invernizzi, C, Lombardo, MG, Lorenzetti, MC, Manca, G, Marino, A, Mattiolo, E, Mazzieri, G, Monti, M, Notario, T, Pagani, D, Petrini, A, Pilati, A, Piredda, A, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Rosta, R, Scrosati, M, Severi, D, Signor, M, Tagliaferri, I, Tassi, D, Viola, P, Virdis, A, Virgillito, S, Virzì, N., AMATO, Gaetano, FRENDA, Alfonso Salvatore, GIAMBALVO, Dario, POMA, Ignazio, RUISI, Paolo, SAIA, Sergio, SARNO, Mauro, VENEZIA, Giacomo, Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Amato, G, Anastasi, U, Attene, G, Baravelli, M, Barbiani, G, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D’Ercole, M, Delbono, S, Demontis, A, Faeti, V, Fecondo, G, Ferrero, C, Fornara, M, Frenda, AS, Fuselli, D, Ghizzoni, R, Giambalvo, D, Innocenti, A, Invernizzi, C, Lombardo, MG, Lorenzetti, MC, Manca, G, Marino, A, Mattiolo, E, Mazzieri, G, Monti, M, Notario, T, Pagani, D, Petrini, A, Pilati, A, Piredda, A, Poma, I, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Rosta, R, Ruisi, P, Saia, S, Sarno, M, Scrosati, M, Severi, D, Signor, M, Tagliaferri, I, Tassi, D, Venezia, G, Viola, P, Virdis, A, Virgillito, S, and Virzì, N

Subjects
Orzo da malto, Varietà, Prove nazionali, Nord, Centro, Sud e Isole, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract

Per il Centro-sud e Isole la produzione ha superato di 0,3 t/ha quella dell’annata precedente attestandosi a 4,8 t/ha, mentre per il Centro-nord la media è stata di sole 3,1 t/ha. La sofferenza della coltura si è manifestata chiaramente anche in termini di ritardo della spigatura, avvenuta nell’ultima decade di maggio

Published
2014

10. Varietà di orzo zootecnico: bene al Sud, meno al Nord

Author

Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Anastasi, U, Attene, G, Baravelli, M, Barbiani, G, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D’Ercole, M, Delbono, S, Demontis, A, Faeti, V, Fecondo, G, Ferrero, C, Fornara, M, Fuselli, D, Ghizzoni, R, Innocenti, A, Invernizzi, C, Lombardo, MG, Lorenzetti, MC, Manca, G, Marino, A, Mattiolo, E, Mazzieri, G, Monti, M, Notario, T, Pagani, D, Petrini, A, Pilati, A, Piredda, A, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Rosta, R, Scrosati, M, Severi, D, Signor, M, Tagliaferri, I, Tassi, D, Viola, P, Virdis, A, Virgillito, S, Virzì, N., AMATO, Gaetano, FRENDA, Alfonso Salvatore, GIAMBALVO, Dario, POMA, Ignazio, RUISI, Paolo, SAIA, Sergio, SARNO, Mauro, VENEZIA, Giacomo, Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Amato, G, Anastasi, U, Attene, G, Baravelli, M, Barbiani, G, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D’Ercole, M, Delbono, S, Demontis, A, Faeti, V, Fecondo, G, Ferrero, C, Fornara, M, Frenda, AS, Fuselli, D, Ghizzoni, R, Giambalvo, D, Innocenti, A, Invernizzi, C, Lombardo, MG, Lorenzetti, MC, Manca, G, Marino, A, Mattiolo, E, Mazzieri, G, Monti, M, Notario, T, Pagani, D, Petrini, A, Pilati, A, Piredda, A, Poma, I, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Rosta, R, Ruisi, P, Saia, S, Sarno, M, Scrosati, M, Severi, D, Signor, M, Tagliaferri, I, Tassi, D, Venezia, G, Viola, P, Virdis, A, Virgillito, S, and Virzì, N

Subjects
Orzo zootecnico, Varietà, Prove nazionali, Nord, Centro, Sud e Isole, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract

Al Nord la media dell' areale è stata di 6,5 t/ha in ripresa rispetto al tracollo della scorsa annata, al Centro è risultata di sole 5,1 t/ha, dato al di sotto delle potenzialità produttive; al Sud la produttività media è stata di 5,7 t/ha, un ottimo risultato che riporta l' areale su livelli elevati

Published
2014

11. Varietà di orzo da malto per la produzione della birra

Author

Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Attene, G, Baravelli, M, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D'Ercole, M, Fecondo, G, Ferrero, C, Fornara, M, Fuselli, D, Invernizzi, C, Lorenzetti, MC, Manca, G, Martelli, M, Mazzieri, G, Notario, T, Pagani, D, Pala, T, Paone, S., Papa, R, Petrini, A, Pilati, A, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Severi, D, Signor, M, Tagliaferri, I, Viola, P, Virdis, A, Virzì, N., AMATO, Gaetano, FRENDA, Alfonso Salvatore, GIAMBALVO, Dario, POMA, Ignazio, RUISI, Paolo, SAIA, Sergio, Cattivelli, L (coord.), Faccini, N (coord.), Gianinetti, A (coord.), Alberici, R, Amato, G, Attene, G, Baravelli, M, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D'Ercole, M, Fecondo, G, Ferrero, C, Fornara, M, Frenda, AS, Fuselli, D, Giambalvo, D, Invernizzi, C, Lorenzetti, MC, Manca, G, Martelli, M, Mazzieri, G, Notario, T, Pagani, D, Pala, T, Paone, S., Papa, R, Petrini, A, Pilati, A, Poma, I, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Ruisi, P, Saia, S, Severi, D, Signor, M, Tagliaferri, I, Viola, P, Virdis, A, and Virzì, N

Subjects
Malt barley, Varietal comparison, Hordeum vulgare, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Published
2013

12. Guida alla scelta delle varietà di triticale per il 2013-14

Author

Faccini, N, Cattivelli, L, Alberici, R, Baronchelli, M, Belocchi, A, Cacciatori, P, Caprara, F, Codianni, P, D’Ercole, M, Fecondo, G, Fornara, M, Fuselli, D, Giunta, F, Manca, G, Martelli, M, Notario, T, Pagani, D, Papa, R, Petrini, A, Pruneddu, G, Quaranta, F, Randazzo, B, Ravaglia, S, Signor, M, Viola, P, Virdis, A, Tagliaferri, I., DI MICELI, Giuseppe, FRENDA, Alfonso Salvatore, POMA, Ignazio, RUISI, Paolo, Faccini, N (coordinatore), Cattivelli, L (coordinatore), Alberici, R, Baronchelli, M, Belocchi, A, Cacciatori, P, Caprara, F, Codianni, P, D’Ercole, M, Di Miceli, G, Fecondo, G, Fornara, M, Frenda, AS, Fuselli, D, Giunta, F, Manca, G, Martelli, M, Notario, T, Pagani, D, Papa, R, Petrini, A, Poma, I, Pruneddu, G, Quaranta, F, Randazzo, B, Ravaglia, S, Ruisi, P, Signor, M, Viola, P, Virdis, A, and Tagliaferri, I

Subjects
Triticale, varietal comparison, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Published
2013

13. Varietà di orzo zootecnico: risultati produttivi e qualitativi

Author

Cattivelli, L, Faccini, N, Gianinetti, A, Alberici, R, Attene, G, Baravelli, M, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D'Ercole, M, Fecondo, G, Ferrero, C, Fornara, M, Fuselli, D, Invernizzi, C, Lorenzetti, MC, Manca, G, Martelli, M, Mazzieri, G, Notario, T, Pagani, D, Pala, T, Paone, S., Papa, R, Petrini, A, Pilati, A, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Severi, D, Signor, M, Tagliaferri, I, Viola, P, Virdis, A, Virzì, N., AMATO, Gaetano, FRENDA, Alfonso Salvatore, GIAMBALVO, Dario, POMA, Ignazio, RUISI, Paolo, SAIA, Sergio, Cattivelli, L (coord.), Faccini, N (coord.), Gianinetti, A (coord.), Alberici, R, Amato, G, Attene, G, Baravelli, M, Baronchelli, M, Belocchi, A, Bonciarelli, U, Cacciatori, P, Caprara, F, Codianni, P, Colonna, M, D'Ercole, M, Fecondo, G, Ferrero, C, Fornara, M, Frenda, AS, Fuselli, D, Giambalvo, D, Invernizzi, C, Lorenzetti, MC, Manca, G, Martelli, M, Mazzieri, G, Notario, T, Pagani, D, Pala, T, Paone, S., Papa, R, Petrini, A, Pilati, A, Poma, I, Pons, R, Preiti, G, Pristeri, A, Quaranta, F, Randazzo, B, Ravaglia, S, Reggiani, F, Rodriguez, M, Romeo, M, Ruisi, P, Saia, S, Severi, D, Signor, M, Tagliaferri, I, Viola, P, Virdis, A, and Virzì, N

Subjects
Malt barley, varietal comparison, Hordeum vulgare, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Published
2013

14. Le varietà di avena per le semine 2013-14

Author

Redaelli, R, Perenzin, M, Notario, T, Cacciatori, P, Cambrea, M, Caprara, F, Codianni, P, Fuselli, D, Invernizzi, C, Petrini, A, Randazzo, B, Reggiani, F, Terzi, V, Viola, P, Virdis, A., POMA, Ignazio, Redaelli, R, Perenzin, M, Notario, T, Cacciatori, P, Cambrea, M, Caprara, F, Codianni, P, Fuselli, D, Invernizzi, C, Petrini, A, Poma, I, Randazzo, B, Reggiani, F, Terzi, V, Viola, P, and Virdis, A

Subjects
Avana sativa, varietà, caratteri bioagronomici, Settore AGR/02 - Agronomia E Coltivazioni Erbacee
Abstract

Nell'areale Nord le produzioni più elevate sono state conseguite dalle varietà più tardive Aveny, Gniady e Teo BD40,insieme alle più precoci Genziana, Bionda e Alcudia. Nelle aree del Centro-sud oltre ad Aveny, Genziana e Gniady, si sono distinte anche Primula e Hamal. Nelle isole si sono differenziate Primula, Alcudia, Genziana, Stella D'oro e Hamel.

Published
2013

16. Risultati delle prove nazionali 2012-13 - varietà di orzo zootecnico: risultati produttivi e qualitativi

Author

Cattivelli, L., Faccini, N., Gianinetti, A., Alberici, R., Amato, G., Attene, G., Baravelli, M., Baronchelli, M., Belocchi, A., Bonciarelli, Umberto, Cacciatori, P., Caprara, F., Codianni, P., Colonna, M., D’Ercole, M., Fecondo, G., Ferrero, C., Fornara, M., Frenda, A. S., Fuselli, D., Giambalvo, D., Invernizzi, C., Lorenzetti, Maria Chiara, Manca, G., Martelli, M., Mazzieri, G., Notario, T., Pagani, D., Pala, T., Paone, S., Papa, R., Petrini, A., Pilati, A., Poma, I., Pons, R., Preiti, I., Pristeri, A., Quaranta, F., Randazzo, B., Ravaglia, S., Reggiani, F., Rodriguez, M., Romeo, M., Ruisi, P., Saia, S., Severi, D., Signor, M., Tagliaferri, I., Viola, P., Virdis, A., and Virzì, N.

Published
2013

18. Pegaso: an ultra-light long duration stratospheric

Author

Romeo G., Peterzen S., Masi S., Di Stefano G., Di Felice F., Ibba R., Cardillo A., Musso I., Benedetti P., Caprara F., Iarocci A., Mari M., Palangio P., Spinelli G., Spoto D., Urbini G., and Drakoy P.

Subjects
tratospheric balloons, Geomagnetic crustal anomalies
Abstract

Launched from the Mario Zuccelli Station (Baia Terra Nova) in Antarctica during the 2005/06 austral summer, the PEGASO-D payload lifted into the stratospheric anticyclone over the southern polar region. This effort marks the first Long Duration Scientific payload to be launched from this location and is the fourth such payload launched in the polar regions. Performing in the framework of the NOBILE/AMUNDSEN collaborative LDB development between ASI-ARR. The Italian Institute of Geophysics and Volcanology (INGV), with the sponsorship of the Italian Antarctic Program (PNRA) and the Italian Space Agency (ASI),designed and built the Ultra-Light system together with three Universities in Italy. The Pegaso program has been created to investigate the Earth magnetic field and provide a precursor series of small payload launches for the bigger LDB program such as OLIMPO, BOOMERanG and BArSPOrt through this collaboration between ASI and ARR. The Italian scientific community, aware of the big advantages that LDB balloons can offer to their experiments, proposed to extend the LDB program to Southern polar regions, besides performing launches from the newly initiated Nobile/Amundsen Stratospheric Balloon Center in Svalbard, Norway.Three PEGASO (Polar Explorer for Geomagnetics And other Scientific Observations) payloads have been launched from the Svalbard (No) in collaboration with Andoya Rocket Range, ASI and ISTAR (Operations and logistics) during the past two northern summers. These stratospheric (altitude m.35000) small 10kmc balloons have floated in the stratosphere between 14 to 39 days measuring the magnetic field of polar regions, by means of a 3-axys-fluxgate magnetometer, during a three year campaign. The study of the magnetic field and its variations is done through permanent observatories. They provide us with high quality data but their spatial distribution is not quite regular, specially in Antarctica due to logistic difficulties. The coverage is improved through marine and aeromagnetic surveys, and also through satellite missions. There exists nevertheless a gap in the wavelengths of the magnetic field represented by these kind of measurements. Satellite data are too far away from Earth's surface to individuate wavelengths lower than 1000 km, and near-ground sur- veys are not able to represent wavelengths longer than the dimensions of the surveyed area. Moreover, there is a region empty of data around the geographical pole for the satellite measurements. The size of these gaps depends on the orbital parameters, but it can reach up to 10 degrees around the pole. PEGASO allows to bridge this gap in the measurements of the magnetic field. Surveys carried out at 35 km height allow the study of crustal anomalies in the range between, we can say, 60 and 1000 km. Taking into account that pathfinders (smaller non-recoverable balloon systems) are usually sent to explore the atmospheric currents, the use of PEGASO as pathfinder allows us to obtain all these results at a very affordable cost. The PEGASO payload was also developed as a single source system integrating science, housekeeping and operational control of the entire balloon borne configuration.Satellite telemetry sent the scientific (magnetometric) data, house-keeping (temperature, solar panel voltage and current, altitude and time) and telecommand (four ballast, two parachute release system, system reset), and powered the terminate system. Data flows through the IRIDIUM telephone service. The onboard systems were kept inside a vessel (white painted and pressurizzed vessel due to power dissipation) except for external flexible solar panels and magnetometer, attached to an external boom. Two redundant tracking systems have been used: a first GPS was integrated inside the on-board telemetry system, necessary to reconstruct position and time of scientific data, while an independent GPS-ARGOS system gave the balloon trajectory, including its descent. Continuous trajectory predictions were made during the missions; they have been necessary, in particular, for the flight safety requirements of the northern hemisphere. The evaluation of the statistical error is proposed. The PEGASO payload was developed to be a light, cost effective way to explore the potential of Ultra-Light Long Duration Ballooning for science as well as an introduction to the earth-space possibilities for students.

Published
2006

19. Potential anatomical determinants of retrograde menstruation: a comprehensive narrative review.

Author

Vercellini P, Piccini M, Caprara F, Cetera GE, Viganò P, and Somigliana E

Subjects
Humans, Female, Menstruation Disturbances, Fallopian Tubes anatomy & histology, Fallopian Tubes pathology, Myometrium pathology, Myometrium anatomy & histology, Cervix Uteri anatomy & histology, Cervix Uteri pathology, Endometriosis pathology
Abstract

A century ago, Sampson identified three uterine anatomical structures that may determine the amount of retrograde menstruation and the likelihood of the development of endometriosis: the cervix, the intramural portion of the fallopian tubes, and the myometrium. Critical appraisal was undertaken of data published over the last 40 years on the potential effect of the characteristics of these three anatomical variables on the risk of endometriosis. There is some evidence to support the pathogenic role of the diameter of the cervical canal, stenosis of internal or external orifices, and stiffness of cervical tissue. One study showed a significant association between the morphology of the intramural tubal tract and the frequency of endometriosis. A large body of evidence points to abnormalities of the myometrial structure as the anatomical aberration most consistently associated with endometriosis. These abnormalities have largely been interpreted as signs of early-onset adenomyosis, which may precede endometriosis and even lead to its development by increasing the amount of retrograde menstruation. Future research should aim to verify whether a positive relationship exists between the substantially increased number of ovulatory menses occurring in the decade following menarche, the development of anatomical myometrial abnormalities, changes in the amount of retrograde menstruation over time, and the risk of endometriosis., (Copyright © 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)

Published
2024
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20. Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates.

Author

Viganò P, Caprara F, Giola F, Di Stefano G, Somigliana E, and Vercellini P

Abstract

Study Question: What are the quantitative, qualitative, and temporal patterns of retrograde mentruation?, Summary Answer: The extreme quantitative and qualitative heterogeneity of the available studies prevents the definitive conclusion that retrograde menstruation is a universal and consistent phenomenon during the reproductive period., What Is Known Already: Retrograde menstruation has been defined as a universal, physiological phenomenon that occurs similarly in about 90% of menstruators during the reproductive period. However, uncertainties still exist in terms of the event frequency, total amount, and cellular composition of retrograde menstruation and the differences between individuals with versus those without endometriosis., Study Design Size Duration: Two systematic reviews were performed, one for human studies, and one for non-human primate studies. We retrieved studies from the PubMed and Embase databases published between 1 January 1980 and 1 November 2023. Studies published in the English language were included and identified using a combination of MeSH terms. References from relevant publications were systematically screened and further articles were identified using PubMed's 'similar articles' and 'cited by' functions., Participants/materials Setting Methods: Results were reported in accordance with the PRISMA guidelines. Studies that did not report original data or provided a review of the field were excluded. Bias analysis was completed for each included human study by using the Newcastle-Ottawa scoring system., Main Results and the Role of Chance: Fifteen studies were finally included in the human systematic review, mostly with limited sample sizes. The macroscopic visualization of blood in PF during menses was reported with a frequency ranging from 9% to 100%. A prevalence of endometrial cells detected in peritoneal fluid ranging from 8% to 75% was reported in the various studies. Controversial findings were reported in relation to patients with endometriosis. Retrograde menstruation has been evaluated cross-sectionally on single occasions, and no information is available on the course of the phenomenon within an entire cycle and between subsequent cycles. Two studies were included in the non-human primate systematic review; one of them showed that retrograde menstruation was observed more frequently in baboons with naturally occurring endometriosis (83%) than in those with a normal pelvis (51%)., Limitations Reasons for Caution: In humans, peritoneal fluid has often been collected at different cycle phases and not systematically during menstruation. The indication for laparoscopy was not always clear for all participants. A wide variety of methods were used to detect endometrial cells, including cytological staining, cell block analysis, immunocytochemistry, and various methods of cell culture., Wider Implication of the Findings: The idea that almost all women experience retrograde menstruation regularly and similarly during their reproductive life is currently unsubstantiated. It is an academic notion accepted uncritically. Development of endometriosis may derive from differences in the frequency or severity of the event., Study Funding/competing Interests: The review was partially funded by Italian Ministry of Health-Current Research IRCCS. P.Vi. serves as co-editor in Chief of Journal of Endometriosis and Uterine Disorders. E.S. serves as Editor in Chief of Human Reproduction Open and discloses research grants from Ferring, Ibsa, Gedeon Richter, and Theramex, and honoraria from Ibsa and Gedeon Richter. P.Ve. serves as Associate Editor for Human Reproduction Open; is a member of the Editorial Board of the Journal of Obstetrics and Gynaecology Canada, of the Italian Journal of Obstetrics and Gynaecology, and of the International Editorial Board of Acta Obstetricia et Gynecologica Scandinavica; has received royalties from Wolters Kluwer for chapters on endometriosis management in the clinical decision support resource UpToDate; and maintains both a public and private gynecological practice. All other authors declare they have no conflict of interest., Registration Number: N/A., Competing Interests: P.Vi. serves as co-editor in Chief of Journal of Endometriosis and Uterine Disorders. E.S. serves as Editor in Chief of Human Reproduction Open and discloses research grants from Ferring, Ibsa, Gedeon Richter, and Theramex, and honoraria from Ibsa and Gedeon Richter. P.Ve. serves as Associate Editor for Human Reproduction Open; is a member of the Editorial Board of the Journal of Obstetrics and Gynaecology Canada, of the Italian Journal of Obstetrics and Gynaecology, and of the International Editorial Board of Acta Obstetricia et Gynecologica Scandinavica; has received royalties from Wolters Kluwer for chapters on endometriosis management in the clinical decision support resource UpToDate; and maintains both a public and private gynecological practice. All other authors declare they have no conflict of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)

Published
2024
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21. Müllerian anomalies and endometriosis as potential explanatory models for the retrograde menstruation/implantation and the embryonic remnants/celomic metaplasia pathogenic theories: a systematic review and meta-analysis.

Author

Vercellini P, Salmeri N, Somigliana E, Piccini M, Caprara F, Viganò P, and De Matteis S

Abstract

Study Question: Does endometriosis prevalence differ in patients with obstructive Müllerian anomalies (OMA) versus those with nonobstructive Müllerian anomalies (NOMA), and in patients with NOMA versus those without Müllerian anomalies?, Summary Answer: The quantitative synthesis of published data demonstrates a substantially increased prevalence of endometriosis in patients with OMA compared with those with NOMA, and a similar prevalence in patients with NOMA and those without Müllerian anomalies., What Is Known Already: The pathogenesis of endometriosis has not been definitively clarified yet. A higher prevalence of endometriosis in patients with OMA than in those with NOMA would support the retrograde menstruation (RM)/implantation theory, whereas a higher prevalence of endometriosis in the NOMA group than in the group without Müllerian anomalies would support the embryonic remnants/celomic metaplasia hypothesis., Study Design, Size, Duration: This systematic review with meta-analysis was restricted to full-length, English-language articles published in peer-reviewed journals between 1980 and 2023. The PubMed and EMBASE databases were searched using the keyword 'endometriosis' in combination with 'Müllerian anomalies', 'obstructive Müllerian anomalies', 'female genital malformations', 'retrograde menstruation', 'infertility', 'pelvic pain', and 'classification'. References from relevant publications were screened, and PubMed's 'similar articles' and 'cited by' functions were used., Participants/materials, Setting, Methods: Studies were selected if they reported the prevalence of surgically confirmed endometriosis in either individuals with OMA compared to those with NOMA, or patients with NOMA compared to those without Müllerian anomalies. Cohort and case-control studies and case series were deemed eligible for inclusion. Noncomparative studies, studies not reporting both the number of individuals with endometriosis and the total number of those with Müllerian anomalies or with other gynecological conditions, those including exclusively data on patients with absent or uncertain menstrual function (e.g. complete Müllerian agenesis category), or with imperforate hymen were excluded. Two reviewers independently abstracted data. The risk of bias was assessed with the Risk of Bias In Non-randomized Studies of Exposures tool. The overall certainty of the evidence was graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines., Main Results and the Role of Chance: Seven retrospective studies were included. The overall mean estimate of endometriosis prevalence was 47% (95% CI, 36-58%) in patients with OMA, and 19% (95% CI, 15-24%) in patients with NOMA, with a common odds ratio (OR) of 4.72 (95% CI, 2.54-8.77). The overall mean estimate of endometriosis prevalence in patients with NOMA was 23% (95% CI, 20-27%), and that in patients without Müllerian anomalies was 21% (95% CI, 20-22%), with a common OR of 0.95 (95% CI, 0.57-1.58). The overall certainty of the evidence according to GRADE guidelines was judged as low for both comparisons., Limitations, Reason for Caution: Some NOMA subtypes may create a partial obstacle to menstrual efflux and/or generate dysfunctional myometrial contractions that favor transtubal reflux, thus increasing the risk of endometriosis and limiting the difference between OMA and NOMA. As infertility and pelvic pain are strongly associated with endometriosis, women with these symptoms are inappropriate controls. Confounding by indication could explain the lack of difference in endometriosis prevalence between patients with NOMA and those without Müllerian anomalies., Wider Implications of the Findings: The results of this meta-analysis support the validity of the RM theory but do not definitively rule out alternative hypotheses. Thus, RM may be considered the initiator for the development of endometriotic lesions, while not excluding the contribution of both inheritable and tissue-specific genetic and epigenetic modifications as disease-promoting factors., Study Funding/competing Interest(s): No funding was received for this review. P.Ve. is a member of the Editorial Board of Human Reproduction Open, the Journal of Obstetrics and Gynaecology Canada, and the International Editorial Board of Acta Obstetricia et Gynecologica Scandinavica; has received royalties from Wolters Kluwer for chapters on endometriosis management in the clinical decision support resource UpToDate; and maintains both a public and private gynecological practice. E.S. discloses payments from Ferring for research grants and honoraria from Merck-Serono for lectures. All other authors declare they have no conflict of interest., Registration Number: N/A., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2024
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22. Non-response to first-line hormonal treatment for symptomatic endometriosis: overcoming tunnel vision. A narrative review.

Author

Cetera GE, Merli CEM, Facchin F, Viganò P, Pesce E, Caprara F, and Vercellini P

Subjects
Humans, Female, Progesterone, Quality of Life, Pain drug therapy, Pain etiology, Endometriosis complications, Endometriosis drug therapy
Abstract

One-fourth to one-third of women with endometriosis receiving first-line hormonal treatment lacks an adequate response in terms of resolution of painful symptoms. This phenomenon has been ascribed to "progesterone resistance", an entity that was theorized to explain the gap between the ubiquity of retrograde menstruation and the 10% prevalence of endometriosis among women of reproductive age.Nevertheless, the hypothesis of progesterone resistance is not free of controversies. As our understanding of endometriosis is increasing, authors are starting to set aside the traditionally accepted tunnel vision of endometriosis as a strictly pelvic disease, opening to a more comprehensive perspective of the condition. The question is: are patients not responding to first-line treatment because they have an altered signaling pathway for such treatment, or have we been overlooking a series of other pain contributors which may not be resolved by hormonal therapy?Finding an answer to this question is evermore impelling, for two reasons mainly. Firstly, because not recognizing the presence of further pain contributors adds a delay in treatment to the already existing delay in diagnosis of endometriosis. This may lead to chronicity of the untreated pain contributors as well as causing adverse consequences on quality of life and psychological health. Secondly, misinterpreting the consequences of untreated pain contributors as a non-response to standard first-line treatment may imply the adoption of second-line medical therapies or of surgery, which may entail non-negligible side effects and may not be free of physical, psychological and socioeconomic repercussions.The current narrative review aims at providing an overview of all the possible pain contributors in endometriosis, ranging from those strictly organic to those with a greater neuro-psychological component. Including these aspects in a broader psychobiological approach may provide useful suggestions for treating those patients who report persistent pain symptoms despite receiving first-line hormonal medical treatment., (© 2023. The Author(s).)

Published
2023
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23. Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives.

Author

De Monte C, Carradori S, Bizzarri B, Bolasco A, Caprara F, Mollica A, Rivanera D, Mari E, Zicari A, Akdemir A, and Secci D

Subjects
14-alpha Demethylase Inhibitors chemistry, 14-alpha Demethylase Inhibitors pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Chemistry Techniques, Synthetic, Drug Design, Drug Evaluation, Preclinical methods, Fungal Proteins antagonists & inhibitors, Fungal Proteins chemistry, Fungal Proteins metabolism, Hep G2 Cells drug effects, Humans, Microbial Sensitivity Tests, Molecular Docking Simulation, Small Molecule Libraries chemistry, Small Molecule Libraries pharmacology, Sterol 14-Demethylase chemistry, Sterol 14-Demethylase metabolism, Structure-Activity Relationship, Thiazolidines pharmacology, Antifungal Agents chemistry, Antifungal Agents pharmacology, Candida drug effects, Thiazolidines chemistry
Abstract

On the basis of the recent findings about the biological properties of thiazolidinones and taking into account the encouraging results about the antifungal activity of some (thiazol-2-yl)hydrazines, new N-substituted heterocyclic derivatives were designed combining the thiazolidinone nucleus with the hydrazonic portion. In details, 1,3-thiazolidin-4-ones bearing (cyclo)aliphatic or (hetero)aromatic moieties linked to the N1-hydrazine at C2 were synthesized and classified into three series according to the aromatic or bicyclic rings connected to the lactam nitrogen of the thiazolidinone. These molecules were assayed for their anti-Candida effects in reference to the biological activity of the conventional topic (clotrimazole, miconazole, tioconazole) and systemic drugs (fluconazole, ketoconazole, amphotericin B). Finally, we investigated the selectivity against fungal cells by testing the compounds endowed with the best MICs on Hep2 cells in order to assess their cell toxicity (CC50) and we noticed that two derivatives were less cytotoxic than the reference drug clotrimazole. Moreover, a preliminary molecular modelling approach has been performed against lanosterol 14-α demethylase (CYP51A1) to rationalize the activity of the tested compounds and to specify the target protein or enzyme., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)

Published
2016
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