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1. Correction: Endobronchial valve positioning for alveolar-pleural fistula following ICU management complicating COVID-19 pneumonia

Author

Donatelli, Pierluigi, Trentacosti, Fabiana, Pellegrino, Maria Rosaria, Tonelli, Roberto, Bruzzi, Giulia, Andreani, Alessandro, Cappiello, Gaia Francesca, Andrisani, Dario, Gozzi, Filippo, Mussini, Cristina, Busani, Stefano, Cavaliere, Gilda Valentina, Girardis, Massimo, Bertellini, Elisabetta, Clini, Enrico, and Marchioni, Alessandro

Published
2022
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2. Lipoaspirate Injection in Relapsing Idiopathic Subglottic Stenosis: Preliminary Results.

Author

Mattioli, Francesco, Serafini, Edoardo, Andreani, Alessandro, Cappiello, Gaia, De Maria, Federico, Marchioni, Daniele, Pinelli, Massimo, and Marchioni, Alessandro

Subjects
TRACHEOTOMY, ANTI-inflammatory agents, T cells, ADIPOSE tissues, DISEASE management, SCIENTIFIC observation, TRACHEOBRONCHOMALACIA, ENDOSCOPIC surgery, TRACHEA, LONGITUDINAL method, GRANULATION tissue, DISEASE relapse, CYTOKINES, GLOTTIS, ENDOSCOPY, HEALTH care teams, DISEASE progression
Abstract

Objectives: The management of idiopathic subglottic stenosis (iSGS) poses a clinical challenge due to high recurrence rates following both endoscopic and open approaches, often leading to tracheostomy. The activation of abnormal T-cells and cytokine pathways has been linked to iSGS pathogenesis. Autologous adipose tissue centrifugation yields lipoaspirate, offering optimal anti-inflammatory effects and biocompatibility widely utilized in various medical settings. This report presents the first 3 cases employing endoscopic dilation (ED) in combination with local lipoaspirate injection to address recurrent iSGS. Methods: A prospective observational study was conducted, involving multidisciplinary evaluation by the Tracheal Team at the University of Modena. Patients meeting specific criteria were directed to undergo ED + lipoaspirate injection. Results: Three patients fulfilled the inclusion criteria. The mean number of prior endoscopic procedures performed was 8. Endoscopic examination revealed 90% stenosis in patient A, 60% stenosis in patient B, and 60% stenosis in patient C. All patients presented inflammatory tissue or incipient granulations at the stenotic site, with an average time of 6 months between previous procedures. After 15 months, none of the patients required further procedures, and endoscopic examination revealed a significant reduction or disappearance of inflammatory tissue with a stable airway lumen. Conclusions: The observed results are encouraging in terms of reducing local inflammation and halting stenosis progression, especially in cases of short-term relapsing iSGS. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Endobronchial valve positioning for alveolar-pleural fistula following ICU management complicating COVID-19 pneumonia

Author

Donatelli, Pierluigi, Trentacosti, Fabiana, Pellegrino, Maria Rosaria, Tonelli, Roberto, Bruzzi, Giulia, Andreani, Alessandro, Cappiello, Gaia Francesca, Andrisani, Dario, Gozzi, Filippo, Mussini, Cristina, Busani, Stefano, Cavaliere, Gilda Valentina, Girardis, Massimo, Bertellini, Elisabetta, Clini, Enrico, and Marchioni, Alessandro

Published
2021
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4. Molecular Biology and Therapeutic Targets of Primitive Tracheal Tumors: Focus on Tumors Derived by Salivary Glands and Squamous Cell Carcinoma

Author

Marchioni, Alessandro, primary, Tonelli, Roberto, additional, Samarelli, Anna Valeria, additional, Cappiello, Gaia Francesca, additional, Andreani, Alessandro, additional, Tabbì, Luca, additional, Livrieri, Francesco, additional, Bosi, Annamaria, additional, Nori, Ottavia, additional, Mattioli, Francesco, additional, Bruzzi, Giulia, additional, Marchioni, Daniele, additional, and Clini, Enrico, additional

Published
2023
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7. Integrated endoscopic treatment of primitive unresectable tracheal tumor: the INTACT retrospective cohort study

Author

Marchioni, Alessandro, primary, Manicardi, Linda, additional, Tonelli, Roberto, additional, Tabbì, Luca, additional, Andrisani, Dario, additional, Lamesta, Antonio, additional, Mocellin, Anna, additional, Bruzzi, Giulia, additional, Cappiello, Gaia, additional, Andreani, Alessandro, additional, Mattioli, Francesco, additional, Filosso, Pierluigi, additional, and Clini, Enrico, additional

Published
2023
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8. Endoscopic closure with double stenting and autologous fascia lata graft of large tracheo-esophageal fistula

Author

Mattioli, Francesco, Serafini, Edoardo, Andreani, Alessandro, Cappiello, Gaia, Marchioni, Daniele, Pinelli, Massimo, Tonelli, Roberto, Clini, Enrico, Marchioni, Alessandro, and Intensive Care Medicine

Subjects
Tracheoesophageal fistula (TEF), Tracheoscopy, fascia lata autograft, bronchoscope, Surgery, stent, Tracheoesophageal fistula (TEF), fascia lata autograft, Tracheoscopy, bronchoscope, stent, tracheoesophageal fistula (TEF), tracheoscopy
Abstract

IntroductionRadiotherapy and esophageal stenting are usually employed to manage esophageal localization of distant cancer. However, they are also related to the occurrence of an increased risk of tracheoesophageal fistula. Tracheoesophageal fistula management in these patients involves dealing with poor general conditions and short-term prognosis. This paper presents the first case in literature of bronchoscopic fistula closure through an autologous fascia lata graft placement between two stents.Case report and aimA 67-years-old male patient was diagnosed with pulmonary squamous cell carcinoma in the inferior lobe of the left lung with mediastinal lymph node metastasis. After a multidisciplinary discussion, bronchoscopic repair of tracheoesophageal fistula with autologous fascia lata was decided without the removal of the esophageal stent due to the high risk on the esophagus possibly related to such a procedure. Oral feeding was progressively introduced without the development of aspiration symptoms. Videofluoroscopy and esophagogastroduodenoscopy were performed at 7 months showing no signs of tracheoesophageal fistula patency.ConclusionThis technique might represent a low risks viable option for patients unsuitable for open surgical approaches.

Published
2023

10. I campi applicativi delle valvole endobronchiali: enfisema, fistole ed emottisi.

Author

Bosi, Annamaria, Nori, Ottavia, Marchioni, Alessandro, Cappiello, Gaia Francesca, Livrieri, Francesco, and Tabbì, Luca

Abstract

Copyright of Rassegna di Patologia dell'Apparato Respiratorio is the property of AIPO - Associazione Italiana Pneumologi Ospedalieri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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11. Stenting versus balloon dilatation in patients with tracheal benign stenosis: The STROBE trial

Author

Marchioni, Alessandro, primary, Andrisani, Dario, additional, Tonelli, Roberto, additional, Andreani, Alessandro, additional, Cappiello, Gaia Francesca, additional, Ori, Margherita, additional, Gozzi, Filippo, additional, Bruzzi, Giulia, additional, Nani, Chiara, additional, Feminò, Raimondo, additional, Manicardi, Linda, additional, Baroncini, Serena, additional, Mattioli, Francesco, additional, Fermi, Matteo, additional, Fantini, Riccardo, additional, Tabbì, Luca, additional, Castaniere, Ivana, additional, Presutti, Livio, additional, and Clini, Enrico, additional

Published
2022
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12. Molecular Mechanisms and Physiological Changes behind Benign Tracheal and Subglottic Stenosis in Adults

Author

Marchioni, Alessandro, primary, Tonelli, Roberto, additional, Andreani, Alessandro, additional, Cappiello, Gaia Francesca, additional, Fermi, Matteo, additional, Trentacosti, Fabiana, additional, Castaniere, Ivana, additional, Fantini, Riccardo, additional, Tabbì, Luca, additional, Andrisani, Dario, additional, Gozzi, Filippo, additional, Bruzzi, Giulia, additional, Manicardi, Linda, additional, Moretti, Antonio, additional, Baroncini, Serena, additional, Samarelli, Anna Valeria, additional, Pinelli, Massimo, additional, De Santis, Giorgio, additional, Stefani, Alessandro, additional, Marchioni, Daniele, additional, Mattioli, Francesco, additional, and Clini, Enrico, additional

Published
2022
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14. ENDOBRONCHIAL VALVE POSITIONING FOR ALVEOLAR-PLEURAL FISTULA COMPLICATING SEVERE COVID-19 PNEUMONIA

Author

Gozzi, Filippo, primary, Tonelli, Roberto, additional, Andrisani, Dario, additional, Castaniere, Ivana, additional, Donatelli, Pierluigi, additional, Trentacosti, Fabiana, additional, Pellegrino, Mariarosaria, additional, Bruzzi, Giulia, additional, Manicardi, Linda, additional, Moretti, Antonio, additional, Nani, Chiara, additional, Cerbone, Caterina, additional, Vermi, Morgana, additional, Andreani, Alessandro, additional, Cappiello, Gaia, additional, Clini, Enrico, additional, and Marchioni, Alessandro, additional

Published
2021
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15. STENTING VERSUS BALLOOON DILATATION IN PATIENTS WITH TRACHEAL BENIGN STENOSIS – THE STROBE TRIAL

Author

Andrisani, Dario, primary, Tonelli, Roberto, additional, Marchioni, Alessandro, additional, Andreani, Alessandro, additional, Cappiello, Gaia, additional, Ori, Margherita, additional, Gozzi, Filippo, additional, Bruzzi, Giulia, additional, Nani, Chiara, additional, Manicardi, Linda, additional, Mattioli, Francesco, additional, Fermi, Matteo, additional, Fantini, Riccardo, additional, Tabbì, Luca, additional, Castaniere, Ivana, additional, Presutti, Livio, additional, and Clini, Enrico, additional

Published
2021
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16. Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung

Author

Marchioni, Alessandro, primary, Tonelli, Roberto, additional, Cerri, Stefania, additional, Castaniere, Ivana, additional, Andrisani, Dario, additional, Gozzi, Filippo, additional, Bruzzi, Giulia, additional, Manicardi, Linda, additional, Moretti, Antonio, additional, Demurtas, Jacopo, additional, Baroncini, Serena, additional, Andreani, Alessandro, additional, Cappiello, Gaia Francesca, additional, Busani, Stefano, additional, Fantini, Riccardo, additional, Tabbì, Luca, additional, Samarelli, Anna Valeria, additional, and Clini, Enrico, additional

Published
2021
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17. Endobronchial valve positioning for alveolar-pleural fistula following ICU management of severe COVID-19 pneumonia

Author

Donatelli, Pierluigi, Trenatacosti, Fabiana, Pellegrino, Maria Rosaria, Tonelli, Roberto, Bruzzi, Giulia, Andreani, Alessandro, Cappiello, Gaia Francesca, Andrisani, Dario, Gozzi, Filippo, Mussini, Cristina, Busani, Stefano, Cavaliere, Gilda Valentina, Girardis, Massimo, Bertellini, Elisabetta, Clini, Enrico, and Marchioni, Alessandro

Subjects
Male, RC705-779, SARS-CoV-2, COVID-19, Pneumothorax, Correction, Case Report, COVID19, bronchopleural fistula, alveolar-pleural fistula, endobronchial valve, Pleural Diseases, Respiration, Artificial, respiratory tract diseases, Klebsiella pneumoniae, Diseases of the respiratory system, Intensive Care Units, Bronchoscopy, Humans, Bronchial Fistula, Respiratory Tract Fistula, Endobronchial valve, Tomography, X-Ray Computed, Alveolar-pleural fistula, Aged
Abstract

Background The main clinical consequences of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection are pneumonia and respiratory failure even requiring mechanical ventilation. In this context, the lung parenchyma is highly prone to ventilator-related injury, with pneumothorax and persistent air leak as the most serious adverse events. So far, endobronchial valve (EBV) positioning has proved efficacious in treating air leaks with a high success rate. Case presentation We report, for the first time, two cases of patients affected by SARS-CoV-2-related pneumonia complicated with bacterial super-infection, experiencing pneumothorax and persistent air leaks after invasive mechanical ventilation. Despite the severity of respiratory failure both patients underwent rigid interventional bronchoscopy and were successfully treated through EBV positioning. Conclusions Persistent air leaks may result from lung tissue damage due to a complex interaction between inflammation and ventilator-related injury (VILI), especially in the advanced stages of ARDS. EBV positioning seems to be a feasible and effective minimally invasive therapeutic option for treating this subset of patients.

Published
2021

18. Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario

Author

Tonelli, Roberto, primary, Marchioni, Alessandro, additional, Tabbì, Luca, additional, Fantini, Riccardo, additional, Busani, Stefano, additional, Castaniere, Ivana, additional, Andrisani, Dario, additional, Gozzi, Filippo, additional, Bruzzi, Giulia, additional, Manicardi, Linda, additional, Demurtas, Jacopo, additional, Andreani, Alessandro, additional, Cappiello, Gaia Francesca, additional, Samarelli, Anna Valeria, additional, and Clini, Enrico, additional

Published
2021
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21. Integrated intErventional bronchoscopy in the treatment of locally adVanced non-small lung cancER with central Malignant airway Obstructions: a multicentric REtrospective study (EVERMORE)

Author

Marchioni, Alessandro, primary, Andrisani, Dario, additional, Tonelli, Roberto, additional, Piro, Roberto, additional, Andreani, Alessandro, additional, Cappiello, Gaia Francesca, additional, Meschiari, Emmanuela, additional, Dominici, Massimo, additional, Bavieri, Mario, additional, Barbieri, Fausto, additional, Taddei, Sofia, additional, Casalini, Eleonora, additional, Falco, Francesco, additional, Gozzi, Filippo, additional, Bruzzi, Giulia, additional, Fantini, Riccardo, additional, Tabbì, Luca, additional, Castaniere, Ivana, additional, Facciolongo, Nicola, additional, and Clini, Enrico, additional

Published
2020
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23. The role of macrophages in interstitial lung diseases

Author

Rossi, Giulio, primary, Cavazza, Alberto, additional, Spagnolo, Paolo, additional, Bellafiore, Salvatore, additional, Kuhn, Elisabetta, additional, Carassai, Pierpaolo, additional, Caramanico, Laura, additional, Montanari, Gloria, additional, Cappiello, Gaia, additional, Andreani, Alessandro, additional, Bono, Francesca, additional, and Nannini, Nazarena, additional

Published
2017
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26. Eosinophilic Globules in Bronchoalveolar Lavage Fluid of Patients With Systemic Sclerosis–Related Interstitial Lung Disease

Author

Rossi, Giulio, primary, Andreani, Alessandro, additional, Morandi, Paola, additional, Marchioni, Alessandro, additional, Corradini, Paolo, additional, Cappiello, Gaia, additional, Bortolotti, Monica, additional, Qosja, Ardian, additional, Manzini, Carlo, additional, Ferri, Clodoveo, additional, Richeldi, Luca, additional, and Cavazza, Alberto, additional

Published
2008
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28. Heerfordt's syndrome.

Author

Andreani, Alessandro, Rossi, Giulio, Giovannini, Michele, and Cappiello, Gaia

Published
2015

29. Unexpected Positron Emission Tomography-Positive Actinomyces-Related Mass of the Bronchial Stump

Author

Andreani, Alessandro, Rossi, Giulio, Giovannini, Michele, and Francesca Cappiello, Gaia

Abstract

Pulmonary actinomycosis is a rare disease frequently misdiagnosed, even by experienced clinicians, as primary or metastatic lung cancer or as other more conventional lung infections. It is often an unexpected disease that is basically detected only on cytological/histological examination. A case involving a patient who presented with a mass in the bronchial stump (of a previous pulmonary lobectomy) is described. Despite a strong suspicion of recurrent lung cancer, positron emission tomography confirmed a diagnosis of a suture-related bronchial actinomycosis.

Published
2012
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30. Integrated endoscopic treatment of primitive unresectable tracheal tumor: the INTACT retrospective cohort study.

Author

Marchioni A, Manicardi L, Tonelli R, Tabbì L, Andrisani D, Lamesta A, Mocellin A, Bruzzi G, Cappiello G, Andreani A, Mattioli F, Filosso P, and Clini E

Abstract

Background: Primitive tracheal tumors represent a rare entity whose management, when unresectable, remains challenging. Primary aim of this study was to explore the survival and the factors influencing prognosis of patients with unresectable primitive tracheal tumor undergoing multimodal treatment integrating interventional bronchoscopy and radiotherapy., Methods: This retrospective cohort study was conducted at the University Hospital of Modena (Italy) over a 12-year period (January 2010 to January 2022) analyzing patients with unresectable primary tracheal tumor receiving interventional bronchoscopy treatment followed by radiotherapy. Survival analysis was conducted for the whole population and according to histology, development of metastasis, stent placement and the onset of disease relapse. The raw and independent association between potential risk factor and 5-year mortality and the reported complications were investigated., Results: A total of 12 patients were included. Five-year survival rate was 42% with a median survival time of 26.7 (interquartile range, 4.1-82) months. Survivors showed a higher prevalence of cystic-adenoid histology (80% vs. 14%), while patients who were dead at 5 years were those with a more advanced T (prevalence of T2: 71% vs. 0%) and a lower response to first line treatment (57% vs. 0%). Treatment complications accounted for stent dislocation (33%) and the onset of granuloma (18%), while no major side effects were reported. The presence of cystic-adenoid histology resulted in significantly improved 5-year survival rate (80% vs. 14%). The onset of distal metastasis, the occurrence of disease relapse and the placement of tracheal stent did not result significantly associated with lower survival. Among analysed variables, only the presence of cystic-adenoid histology resulted independently associated with survival (odds ratio =0.1, P=0.04)., Conclusions: Multimodal treatment including interventional bronchoscopy and associated radiotherapy for unresectable primary tracheal tumors seems not burdened by significant complications and may provide benefits in terms of survival for those patients with cystic-adenoid histology., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-23-738/coif). The authors have no conflicts of interest to declare., (2024 Journal of Thoracic Disease. All rights reserved.)

Published
2024
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