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1. Development and multicenter validation of a multiparametric imaging model to predict treatment response in rectal cancer

Author

Schurink, Niels W., van Kranen, Simon R., van Griethuysen, Joost J. M., Roberti, Sander, Snaebjornsson, Petur, Bakers, Frans C. H., de Bie, Shira H., Bosma, Gerlof P. T., Cappendijk, Vincent C., Geenen, Remy W. F., Neijenhuis, Peter A., Peterson, Gerald M., Veeken, Cornelis J., Vliegen, Roy F. A., Peters, Femke P., Bogveradze, Nino, el Khababi, Najim, Lahaye, Max J., Maas, Monique, Beets, Geerard L., Beets-Tan, Regina G. H., and Lambregts, Doenja M. J.

Published
2023
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2. Long-Term Outcome of Immediate Versus Postponed Intervention in Patients With Infected Necrotizing Pancreatitis (POINTER): Multicenter Randomized Trial

Author

Van Veldhuisen, Charlotte L., Sissingh, Noor J., Boxhoorn, Lotte, van Dijk, Sven M., van Grinsven, Janneke, Verdonk, Robert C., Boermeester, Marja A., Bouwense, Stefan A.W., Bruno, Marco J., Cappendijk, Vincent C., van Duijvendijk, Peter, van Eijck, Casper H J., Fockens, Paul, van Goor, Harry, Hadithi, Muhammed, Haveman, Jan Willem, Jacobs, Maarten A.J.M., Jansen, Jeroen M., Kop, Marnix P.M., Manusama, Eric R., Mieog, J. Sven D., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Poen, Alexander C., Poley, Jan-Werner, Quispel, Rutger, Römkens, Tessa E.H., Schwartz, Matthijs P., Seerden, Tom C., Dijkgraaf, Marcel G.W., Stommel, Martijn W.J., Straathof, Jan Willem A., Venneman, Niels G., Voermans, Rogier P., van Hooft, Jeanin E., van Santvoort, Hjalmar C., and Besselink, Marc G.

Published
2024
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3. MRI in addition to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): an international, multicentre, prospective, diagnostic accuracy trial

Author

Ayez, Ninos, Bnà, Claudio, van den Boom, Rivka, Lambregts, Doenja J.M., Liefers, Gerrit-Jan, de Meyere, Celine, Draaisma, Werner A., Gerhards, Michael F., Imani, Farshad, Ruers, Theo .J.M., Liem, Mike S.L., Serafino, Gian Piero, van Beek, Hermen C., van der Hoeven, Joost A.B., Veeken, Cornelis J., Zonderhuis, Babs M., Görgec, Burak, Hansen, Ingrid S, Kemmerich, Gunter, Syversveen, Trygve, Abu Hilal, Mohammed, Belt, Eric J T, Bosscha, Koop, Burgmans, Mark C, Cappendijk, Vincent C, D'Hondt, Mathieu, Edwin, Bjørn, van Erkel, Arian R, Gielkens, Hugo A J, Grünhagen, Dirk J, Gobardhan, Paul D, Hartgrink, Henk H, Horsthuis, Karin, Klompenhouwer, Elisabeth G, Kok, Niels F M, Kint, Peter A M, Kuhlmann, Koert, Leclercq, Wouter K G, Lips, Daan J, Lutin, Bart, Maas, Monique, Marsman, Hendrik A, Meijerink, Martijn, Meyer, Yannick, Morone, Mario, Peringa, Jan, Sijberden, Jasper P, van Delden, Otto M, van den Bergh, Janneke E, Vanhooymissen, Inge J S, Vermaas, Maarten, Willemssen, François E J A, Dijkgraaf, Marcel G W, Bossuyt, Patrick M, Swijnenburg, Rutger-Jan, Fretland, Åsmund A, Verhoef, Cornelis, Besselink, Marc G, and Stoker, Jaap

Published
2024
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4. The sigmoid take-off as a landmark to distinguish rectal from sigmoid tumours on MRI: Reproducibility, pitfalls and potential impact on treatment stratification

Author

Alberts, Femke, Bakers, Frans C.H., Batiashvili, Nino, Beets, Geerard L., Beets-Tan, Regina G.H., de Bie, Shira, Bogveradze, Nino, Bosma, Gerlof, Cappendijk, Vincent C., Castagnoli, Francesca, Daushvili, Ana, Doornebosch, Pascal, Dresen, Raphaëla C., Geenen, Remy, Grotenhuis, Brechtje, Jokharidze, Tedo, el Khababi, Najim, Kusters, Miranda, Lahaye, Max J., Lambregts, Doenja M.J., Landolfi, Federica, Leeuwenburgh, Marjolein, Maas, Monique, Neijenhuis, Peter, Peterson, Gerald, Steller, Ernst J.A., Veeken, Cornelis J., Tanis, Pieter J., De Vuysere, Sofie, Vermaas, Maarten, Vliegen, Roy F.A., and Wolthuis, Albert

Published
2022
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5. Sources of variation in multicenter rectal MRI data and their effect on radiomics feature reproducibility

Author

Schurink, Niels W., van Kranen, Simon R., Roberti, Sander, van Griethuysen, Joost J. M., Bogveradze, Nino, Castagnoli, Francesca, el Khababi, Najim, Bakers, Frans C. H., de Bie, Shira H., Bosma, Gerlof P. T., Cappendijk, Vincent C., Geenen, Remy W. F., Neijenhuis, Peter A., Peterson, Gerald M., Veeken, Cornelis J., Vliegen, Roy F. A., Beets-Tan, Regina G. H., and Lambregts, Doenja M. J.

Published
2022
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7. MRI in addition to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): an international, multicentre, prospective, diagnostic accuracy trial

Author

Görgec, Burak, primary, Hansen, Ingrid S, additional, Kemmerich, Gunter, additional, Syversveen, Trygve, additional, Abu Hilal, Mohammed, additional, Belt, Eric J T, additional, Bosscha, Koop, additional, Burgmans, Mark C, additional, Cappendijk, Vincent C, additional, D'Hondt, Mathieu, additional, Edwin, Bjørn, additional, van Erkel, Arian R, additional, Gielkens, Hugo A J, additional, Grünhagen, Dirk J, additional, Gobardhan, Paul D, additional, Hartgrink, Henk H, additional, Horsthuis, Karin, additional, Klompenhouwer, Elisabeth G, additional, Kok, Niels F M, additional, Kint, Peter A M, additional, Kuhlmann, Koert, additional, Leclercq, Wouter K G, additional, Lips, Daan J, additional, Lutin, Bart, additional, Maas, Monique, additional, Marsman, Hendrik A, additional, Meijerink, Martijn, additional, Meyer, Yannick, additional, Morone, Mario, additional, Peringa, Jan, additional, Sijberden, Jasper P, additional, van Delden, Otto M, additional, van den Bergh, Janneke E, additional, Vanhooymissen, Inge J S, additional, Vermaas, Maarten, additional, Willemssen, François E J A, additional, Dijkgraaf, Marcel G W, additional, Bossuyt, Patrick M, additional, Swijnenburg, Rutger-Jan, additional, Fretland, Åsmund A, additional, Verhoef, Cornelis, additional, Besselink, Marc G, additional, Stoker, Jaap, additional, Ayez, Ninos, additional, Bnà, Claudio, additional, van den Boom, Rivka, additional, Lambregts, Doenja J.M., additional, Liefers, Gerrit-Jan, additional, de Meyere, Celine, additional, Draaisma, Werner A., additional, Gerhards, Michael F., additional, Imani, Farshad, additional, Ruers, Theo .J.M., additional, Liem, Mike S.L., additional, Serafino, Gian Piero, additional, van Beek, Hermen C., additional, van der Hoeven, Joost A.B., additional, Veeken, Cornelis J., additional, and Zonderhuis, Babs M., additional

Published
2023
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8. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

Manusama, Eric R, Hadithi, Mohammed, Rosman, Camiel, Schaapherder, Alexander F, Schoon, Erik J, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C, Bakker, Olaf J, Besselink, Marc G, Boermeester, Marja A, Bollen, Thomas L, Bosscha, Koop, Bouwense, Stefan A, Bruno, Marco J, Cappendijk, Vincent C, Consten, Esther C, Dejong, Cornelis H, van Eijck, Casper H, Erkelens, Willemien G, van Goor, Harry, van Grevenstein, Wilhelmina M U, Haveman, Jan-Willem, Hofker, Sijbrand H, Jansen, Jeroen M, Laméris, Johan S, van Lienden, Krijn P, Meijssen, Maarten A, Mulder, Chris J, Nieuwenhuijs, Vincent B, Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J, Römkens, Tessa E, Scheepers, Joris J, Schepers, Nicolien J, Schwartz, Matthijs P, Seerden, Tom, Spanier, B W Marcel, Straathof, Jan Willem A, Strijker, Marin, Timmer, Robin, Venneman, Niels G, Vleggaar, Frank P, Voermans, Rogier P, Witteman, Ben J, Gooszen, Hein G, Dijkgraaf, Marcel G, and Fockens, Paul

Published
2018
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9. Predicting response to chemoradiotherapy in rectal cancer via visual morphologic assessment and staging on baseline MRI: a multicenter and multireader study.

Author

El Khababi, Najim, Beets-Tan, Regina G. H., Tissier, Renaud, Lahaye, Max J., Maas, Monique, Curvo-Semedo, Luís, Dresen, Raphaëla C., Nougaret, Stephanie, Beets, Geerard L., Lambregts, Doenja M. J., Bakers, Frans C. H., Barros, Perla, Bauer, Ferdinand, de Bie, Shira H, Ballantyne, Stuart, Dutra, Joanna Brayner, Buskov, Laura, Bogveradze, Nino, Bosma, Gerlof P. T., and Cappendijk, Vincent C

Subjects
ENDORECTAL ultrasonography, RECTAL cancer, CHEMORADIOTHERAPY, DISEASE risk factors, NEOADJUVANT chemotherapy, RECEIVER operating characteristic curves
Abstract

Purpose: Pre-treatment knowledge of the anticipated response of rectal tumors to neoadjuvant chemoradiotherapy (CRT) could help to further optimize the treatment. Van Griethuysen et al. proposed a visual 5-point confidence score to predict the likelihood of response on baseline MRI. Aim was to evaluate this score in a multicenter and multireader study setting and compare it to two simplified (4-point and 2-point) adaptations in terms of diagnostic performance, interobserver agreement (IOA), and reader preference. Methods: Twenty-two radiologists from 14 countries (5 MRI-experts,17 general/abdominal radiologists) retrospectively reviewed 90 baseline MRIs to estimate if patients would likely achieve a (near-)complete response (nCR); first using the 5-point score by van Griethuysen (1=highly unlikely to 5=highly likely to achieve nCR), second using a 4-point adaptation (with 1-point each for high-risk T-stage, obvious mesorectal fascia invasion, nodal involvement, and extramural vascular invasion), and third using a 2-point score (unlikely/likely to achieve nCR). Diagnostic performance was calculated using ROC curves and IOA using Krippendorf's alpha (α). Results: Areas under the ROC curve to predict the likelihood of a nCR were similar for the three methods (0.71–0.74). IOA was higher for the 5- and 4-point scores (α=0.55 and 0.57 versus 0.46 for the 2-point score) with best results for the MRI-experts (α=0.64-0.65). Most readers (55%) favored the 4-point score. Conclusions: Visual morphologic assessment and staging methods can predict neoadjuvant treatment response with moderate–good performance. Compared to a previously published confidence-based scoring system, study readers preferred a simplified 4-point risk score based on high-risk T-stage, MRF involvement, nodal involvement, and EMVI. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Immediate versus postponed intervention for infected necrotizing pancreatitis

Author

Boxhoorn, Lotte, van Dijk, Sven M., van Grinsven, Janneke, Verdonk, Robert C., Boermeester, Marja A., Bollen, Thomas L., Bouwense, Stefan A. W., Bruno, Marco J., Cappendijk, Vincent C., Dejong, Cornelis H. C., van Duijvendijk, Peter, van Eijck, Casper H. J., Fockens, Paul, Francken, Michiel F. G., van Goor, Harry, Hadithi, Muhammed, Hallensleben, Nora D. L., Haveman, Jan Willem, Jacobs, Maarten A. J. M., Jansen, Jeroen M., Kop, Marnix P. M., van Lienden, Krijn P., Manusama, Eric R., Mieog, Sven J. D., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Poen, Alexander C., Poley, Jan-Werner, van de Poll, Marcel, Quispel, Rutger, Römkens, Tessa E. H., Schwartz, Matthijs P., Seerden, Tom C., Stommel, Martijn W. J., Straathof, Jan Willem A., Timmerhuis, Hester C., Venneman, Niels G., Voermans, Rogier P., van de Vrie, Wim, Witteman, Ben J., Dijkgraaf, Marcel G. W., van Santvoort, Hjalmar C., Besselink, Marc G., Study group members AMC, Stoker, Jaap, Gastroenterology & Hepatology, Surgery, Gastroenterology and Hepatology, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, Epidemiology and Data Science, APH - Methodology, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Intensive Care, and MUMC+: MA Medische Staf IC (9)

Subjects
medicine.medical_specialty, MEDLINE, Disease, CLASSIFICATION, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Randomized controlled trial, law, Intervention (counseling), Catheter drainage, MANAGEMENT, Medicine, Combined Modality Therapy, STEP-UP APPROACH, OUTCOMES, business.industry, NECROSIS, General Medicine, NECROSECTOMY, medicine.disease, digestive system diseases, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Pancreatitis, business, Necrotizing pancreatitis
Abstract

Item does not contain fulltext BACKGROUND: Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown. METHODS: We conducted a multicenter, randomized superiority trial involving patients with infected necrotizing pancreatitis, in which we compared immediate drainage within 24 hours after randomization once infected necrosis was diagnosed with drainage that was postponed until the stage of walled-off necrosis was reached. The primary end point was the score on the Comprehensive Complication Index, which incorporates all complications over the course of 6 months of follow-up. RESULTS: A total of 104 patients were randomly assigned to immediate drainage (55 patients) or postponed drainage (49 patients). The mean score on the Comprehensive Complication Index (scores range from 0 to 100, with higher scores indicating more severe complications) was 57 in the immediate-drainage group and 58 in the postponed-drainage group (mean difference, -1; 95% confidence interval [CI], -12 to 10; P = 0.90). Mortality was 13% in the immediate-drainage group and 10% in the postponed-drainage group (relative risk, 1.25; 95% CI, 0.42 to 3.68). The mean number of interventions (catheter drainage and necrosectomy) was 4.4 in the immediate-drainage group and 2.6 in the postponed-drainage group (mean difference, 1.8; 95% CI, 0.6 to 3.0). In the postponed-drainage group, 19 patients (39%) were treated conservatively with antibiotics and did not require drainage; 17 of these patients survived. The incidence of adverse events was similar in the two groups. CONCLUSIONS: This trial did not show the superiority of immediate drainage over postponed drainage with regard to complications in patients with infected necrotizing pancreatitis. Patients randomly assigned to the postponed-drainage strategy received fewer invasive interventions. (Funded by Fonds NutsOhra and Amsterdam UMC; POINTER ISRCTN Registry number, ISRCTN33682933.).

Published
2021

11. Sense and nonsense of yT‐staging on MRI after chemoradiotherapy in rectal cancer.

Author

El Khababi, Najim, Beets‐Tan, Regina G. H., Tissier, Renaud, Lahaye, Max J., Maas, Monique, Curvo‐Semedo, Luís, Dresen, Raphaëla C., Nougaret, Stephanie, Beets, Geerard L., Lambregts, Doenja M. J., Bakers, Frans C. H., Ballantyne, Stuart, Barros, Perla, Bauer, Ferdinand, de Bie, Shira H., Bogveradze, Nino, Bosma, Gerlof P. T., Brayner Dutra, Joanna, Buskov, Laura, and Cappendijk, Vincent C.

Subjects
RECTAL cancer, CHEMORADIOTHERAPY, MAGNETIC resonance imaging, PRESERVATION of organs, tissues, etc., RECTUM tumors, CANCER patients
Abstract

Aim: The aim of this work was to investigate the value of rectal cancer T‐staging on MRI after chemoradiotherapy (ymrT‐staging) in relation to the degree of fibrotic transformation of the tumour bed as assessed using the pathological tumour regression grade (pTRG) of Mandard as a standard of reference. Method: Twenty two radiologists, including five rectal MRI experts and 17 'nonexperts' (general/abdominal radiologists), evaluated the ymrT stage on the restaging MRIs of 90 rectal cancer patients after chemoradiotherapy. The ymrT stage was compared with the final ypT stage at histopathology; the percentages of correct staging (ymrT = ypT), understaging (ymrT < ypT) and overstaging (ymrT > ypT) were calculated and compared between patients with predominant tumour at histopathology (pTRG4–5) and patients with predominant fibrosis (pTRG1–3). Interobserver agreement (IOA) was computed using Krippendorff's alpha. Results: Average ymrT/ypT stage concordance was 48% for the experts and 43% for the nonexperts; ymrT/ypT stage concordance was significantly higher in the pTRG4–5 subgroup (58% vs. 41% for the pTRG1–3 group; p = 0.01), with the best results for the MRI experts. Overstaging was the main source of error, especially in the pTRG1–3 subgroup (average overstaging rate 38%–44% vs. 13%–55% in the pTRG4–5 subgroup). IOA was higher for the expert versus nonexpert readers (α = 0.67 vs. α = 0.39). Conclusions: ymrT‐staging is moderately accurate; accuracy is higher in poorly responding patients with predominant tumour but low in good responders with predominant fibrosis, resulting in significant overstaging. Radiologists should shift their focus from ymrT‐staging to detecting gross residual (and progressive) disease, and identifying potential candidates for organ preservation who would benefit from further clinical and endoscopic evaluation to guide final treatment planning. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial

Author

Onnekink, Anke M., primary, Boxhoorn, Lotte, additional, Timmerhuis, Hester C., additional, Bac, Simon T., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas L., additional, Bosscha, Koop, additional, Bouwense, Stefan A.W., additional, Bruno, Marco J., additional, van Brunschot, Sandra, additional, Cappendijk, Vincent C., additional, Consten, Esther C.J., additional, Dejong, Cornelis H., additional, Dijkgraaf, Marcel G.W., additional, van Eijck, Casper H.J., additional, Erkelens, Willemien G., additional, van Goor, Harry, additional, van Grinsven, Janneke, additional, Haveman, Jan-Willem, additional, van Hooft, Jeanin E., additional, Jansen, Jeroen M., additional, van Lienden, Krijn P., additional, Meijssen, Maarten A.C., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, de Ridder, Rogier J., additional, Römkens, Tessa E.H., additional, van Santvoort, Hjalmar C., additional, Scheepers, Joris J., additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Spanier, Marcel B.W., additional, Straathof, Jan Willem A., additional, Timmer, Robin, additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Vleggaar, Frank P., additional, van Wanrooij, Roy L., additional, Witteman, Ben J.M., additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2022
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13. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION):Long-term Follow-up of a Randomized Trial

Author

Onnekink, Anke M., Boxhoorn, Lotte, Timmerhuis, Hester C., Bac, Simon T., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A.W., Bruno, Marco J., van Brunschot, Sandra, Cappendijk, Vincent C., Consten, Esther C.J., Dejong, Cornelis H., Dijkgraaf, Marcel G.W., van Eijck, Casper H.J., Erkelens, Willemien G., van Goor, Harry, van Grinsven, Janneke, Haveman, Jan Willem, van Hooft, Jeanin E., Jansen, Jeroen M., van Lienden, Krijn P., Meijssen, Maarten A.C., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Römkens, Tessa E.H., van Santvoort, Hjalmar C., Scheepers, Joris J., Schwartz, Matthijs P., Seerden, Tom, Spanier, Marcel B.W., Straathof, Jan Willem A., Timmer, Robin, Venneman, Niels G., Verdonk, Robert C., Vleggaar, Frank P., van Wanrooij, Roy L., Witteman, Ben J.M., Fockens, Paul, Voermans, Rogier P., Onnekink, Anke M., Boxhoorn, Lotte, Timmerhuis, Hester C., Bac, Simon T., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A.W., Bruno, Marco J., van Brunschot, Sandra, Cappendijk, Vincent C., Consten, Esther C.J., Dejong, Cornelis H., Dijkgraaf, Marcel G.W., van Eijck, Casper H.J., Erkelens, Willemien G., van Goor, Harry, van Grinsven, Janneke, Haveman, Jan Willem, van Hooft, Jeanin E., Jansen, Jeroen M., van Lienden, Krijn P., Meijssen, Maarten A.C., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Römkens, Tessa E.H., van Santvoort, Hjalmar C., Scheepers, Joris J., Schwartz, Matthijs P., Seerden, Tom, Spanier, Marcel B.W., Straathof, Jan Willem A., Timmer, Robin, Venneman, Niels G., Verdonk, Robert C., Vleggaar, Frank P., van Wanrooij, Roy L., Witteman, Ben J.M., Fockens, Paul, and Voermans, Rogier P.

Abstract

Background & Aims: Previous randomized trials, including the Transluminal Endoscopic Step-Up Approach Versus Minimally Invasive Surgical Step-Up Approach in Patients With Infected Pancreatic Necrosis (TENSION) trial, demonstrated that the endoscopic step-up approach might be preferred over the surgical step-up approach in patients with infected necrotizing pancreatitis based on favorable short-term outcomes. We compared long-term clinical outcomes of both step-up approaches after a period of at least 5 years. Methods: In this long-term follow-up study, we reevaluated all clinical data on 83 patients (of the originally 98 included patients) from the TENSION trial who were still alive after the initial 6-month follow-up. The primary end point, similar to the TENSION trial, was a composite of death and major complications. Secondary end points included individual major complications, pancreaticocutaneous fistula, reinterventions, pancreatic insufficiency, and quality of life. Results: After a mean follow-up period of 7 years, the primary end point occurred in 27 patients (53%) in the endoscopy group and in 27 patients (57%) in the surgery group (risk ratio [RR], 0.93; 95% confidence interval [CI], 0.65–1.32; P = .688). Fewer pancreaticocutaneous fistulas were identified in the endoscopy group (8% vs 34%; RR, 0.23; 95% CI, 0.08–0.83). After the initial 6-month follow-up, the endoscopy group needed fewer reinterventions than the surgery group (7% vs 24%; RR, 0.29; 95% CI, 0.09–0.99). Pancreatic insufficiency and quality of life did not differ between groups. Conclusions: At long-term follow-up, the endoscopic step-up approach was not superior to the surgical step-up approach in reducing death or major complications in patients with infected necrotizing pancreatitis. However, patients assigned to the endoscopic approach developed overall fewer pancreaticocutaneous fistulas and needed fewer reinterventions after the initial 6-month follow-up. Netherlands Tria

Published
2022

14. Comparison of MRI response evaluation methods in rectal cancer: a multicentre and multireader validation study.

Author

El Khababi, Najim, Beets-Tan, Regina G. H., Tissier, Renaud, Lahaye, Max J., Maas, Monique, Curvo-Semedo, Luís, Dresen, Raphaëla C., Nougaret, Stephanie, Beets, Geerard L., Lambregts, Doenja M. J., Bakers, Frans C. H., Barros, Perla, Bauer, Ferdinand, de Bie, Shira H., Ballantyne, Stuart, Dutra, Joanna Brayner, Buskov, Laura, Bogveradze, Nino, Bosma, Gerlof P. T., and Cappendijk, Vincent C.

Subjects
RECTAL cancer, MAGNETIC resonance imaging, EVALUATION methodology, RECTUM tumors, TUMOR grading
Abstract

Objectives: To compare four previously published methods for rectal tumor response evaluation after chemoradiotherapy on MRI. Methods: Twenty-two radiologists (5 rectal MRI experts, 17 general/abdominal radiologists) retrospectively reviewed the post-chemoradiotherapy MRIs of 90 patients, scanned at 10 centers (with non-standardized protocols). They applied four response methods; two based on T2W-MRI only (MRI tumor regression grade (mrTRG); split-scar sign), and two based on T2W-MRI+DWI (modified-mrTRG; DWI-patterns). Image quality was graded using a 0–6-point score (including slice thickness and in-plane resolution; sequence angulation; DWI b-values, signal-to-noise, and artefacts); scores < 4 were classified below average. Mixed model linear regression was used to calculate average sensitivity/specificity/accuracy to predict a complete response (versus residual tumor) and assess the impact of reader experience and image quality. Group interobserver agreement (IOA) was calculated using Krippendorff's alpha. Readers were asked to indicate their preferred scoring method(s). Results: Average sensitivity/specificity/accuracy was 57%/64%/62% (mrTRG), 36%/79%/66% (split-scar), 40%/79%/67% (modified-mrTRG), and 37%/82%/68% (DWI-patterns); mrTRG showed higher sensitivity but lower specificity and accuracy (p < 0.001) compared to the other methods. IOA was lower for the split scar method (0.18 vs. 0.39–0.43). Higher reader experience had a significant positive effect on diagnostic performance and IOA (except for the split scar sign); below-average imaging quality had a significant negative effect on diagnostic performance. DWI pattern was selected as the preferred method by 73% of readers. Conclusions: Methods incorporating DWI showed the most favorable results when combining diagnostic performance, IOA, and reader preference. Reader experience and image quality clearly impacted diagnostic performance emphasizing the need for state-of-the-art imaging and dedicated radiologist training. Key Points: • In a multireader study comparing 4 MRI methods for rectal tumor response evaluation, those incorporating DWI showed the best results when combining diagnostic performance, IOA, and reader preference. • The most preferred method (by 73% of readers) was the "DWI patterns" approach with an accuracy of 68%, high specificity of 82%, and group IOA of 0.43. • Reader experience level and MRI quality had an evident effect on diagnostic performance and IOA. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis

Author

Boxhoorn, Lotte, primary, Verdonk, Robert C, additional, Besselink, Marc G, additional, Boermeester, Marja, additional, Bollen, Thomas L, additional, Bouwense, Stefan AW, additional, Cappendijk, Vincent C, additional, Curvers, Wouter L, additional, Dejong, Cornelis H, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, van Eijck, Casper HJ, additional, van Geenen, Erwin JM, additional, Hadithi, Muhammed, additional, Hazen, Wouter L, additional, Honkoop, Pieter, additional, van Hooft, Jeanin E, additional, Jacobs, Maarten AJM, additional, Kievits, June EC, additional, Kop, Marnix PM, additional, Kouw, Eva, additional, Kuiken, Sjoerd D, additional, Ledeboer, Michiel, additional, Nieuwenhuijs, Vincent B, additional, Perk, Lars E, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, de Ridder, Rogier JJ, additional, van Santvoort, Hjalmar C, additional, Sperna Weiland, Christina J, additional, Stommel, Martijn WJ, additional, Timmerhuis, Hester C, additional, Witteman, Ben J, additional, Umans, Devica S, additional, Venneman, Niels G, additional, Vleggaar, Frank P, additional, van Wanrooij, Roy LJ, additional, Bruno, Marco J, additional, Fockens, Paul, additional, and Voermans, Rogier P, additional

Published
2022
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16. The sigmoid take-off as a landmark to distinguish rectal from sigmoid tumours on MRI: Reproducibility, pitfalls and potential impact on treatment stratification

Author

Bogveradze, Nino, primary, Lambregts, Doenja M.J., additional, el Khababi, Najim, additional, Dresen, Raphaëla C., additional, Maas, Monique, additional, Kusters, Miranda, additional, Tanis, Pieter J., additional, Beets-Tan, Regina G.H., additional, Alberts, Femke, additional, Bakers, Frans C.H., additional, Batiashvili, Nino, additional, Beets, Geerard L., additional, de Bie, Shira, additional, Bogveradze, Nino, additional, Bosma, Gerlof, additional, Cappendijk, Vincent C., additional, Castagnoli, Francesca, additional, Daushvili, Ana, additional, Doornebosch, Pascal, additional, Geenen, Remy, additional, Grotenhuis, Brechtje, additional, Jokharidze, Tedo, additional, Lahaye, Max J., additional, Landolfi, Federica, additional, Leeuwenburgh, Marjolein, additional, Neijenhuis, Peter, additional, Peterson, Gerald, additional, Steller, Ernst J.A., additional, Veeken, Cornelis J., additional, De Vuysere, Sofie, additional, Vermaas, Maarten, additional, Vliegen, Roy F.A., additional, and Wolthuis, Albert, additional

Published
2022
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18. Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis.

Author

Boxhoorn, Lotte, Verdonk, Robert C., Besselink, Marc G., Boermeester, Marja, Bollen, Thomas L., Bouwense, Stefan A. W., Cappendijk, Vincent C., Curvers, Wouter L., Dejong, Cornelis H., van Dijk, Sven M., van Dullemen, Hendrik M., van Eijck, Casper H. J., van Geenen, Erwin J. M., Hadithi, Muhammed, Hazen, Wouter L., Honkoop, Pieter, van Hooft, Jeanin E., Jacobs, Maarten A. J. M., Kievits, June E. C., and Kop, Marnix P. M.

Subjects
NECROTIZING pancreatitis, ENDOSCOPIC retrograde cholangiopancreatography, NONINVASIVE ventilation, MEDICAL ethics, PANCREATITIS
Published
2023
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19. Sources of variation in multicenter rectal MRI data and their effect on radiomics feature reproducibility

Author

Schurink, Niels W., primary, van Kranen, Simon R., additional, Roberti, Sander, additional, van Griethuysen, Joost J. M., additional, Bogveradze, Nino, additional, Castagnoli, Francesca, additional, el Khababi, Najim, additional, Bakers, Frans C. H., additional, de Bie, Shira H., additional, Bosma, Gerlof P. T., additional, Cappendijk, Vincent C., additional, Geenen, Remy W. F., additional, Neijenhuis, Peter A., additional, Peterson, Gerald M., additional, Veeken, Cornelis J., additional, Vliegen, Roy F. A., additional, Beets-Tan, Regina G. H., additional, and Lambregts, Doenja M. J., additional

Published
2021
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20. Evolutions in rectal cancer MRI staging and risk stratification in The Netherlands

Author

Bogveradze, Nino, primary, el Khababi, Najim, additional, Schurink, Niels W., additional, van Griethuysen, Joost J. M., additional, de Bie, Shira, additional, Bosma, Gerlof, additional, Cappendijk, Vincent C., additional, Geenen, Remy W. F., additional, Neijenhuis, Peter, additional, Peterson, Gerald, additional, Veeken, Cornelis J., additional, Vliegen, Roy F. A., additional, Maas, Monique, additional, Lahaye, Max J., additional, Beets, Geerard L., additional, Beets-Tan, Regina G. H., additional, and Lambregts, Doenja M. J., additional

Published
2021
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24. ID: 3519933 LUMEN-APPOSING METAL STENTS VERSUS DOUBLE-PIGTAIL PLASTIC STENTS IN THE ENDOSCOPIC STEP-UP APPROACH FOR INFECTED NECROTIZING PANCREATITIS

Author

Boxhoorn, Lotte, primary, Verdonk, Robert C., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas, additional, Bouwense, Stefan A., additional, Cappendijk, Vincent C., additional, Curvers, Wouter, additional, Dejong, Cornelis H., additional, van Dijk, Sven M., additional, Van Dullemen, Hendrik M., additional, Van Eijck, Casper H., additional, Van Geenen, Erwin-Jan M., additional, Hadithi, Muhammed, additional, Hazen, Wouter L., additional, Honkoop, Pieter, additional, van Hooft, Jeanin E., additional, Jacobs, Maarten, additional, Kouw, Eva, additional, Kuiken, Sjoerd D., additional, Ledeboer, Michiel, additional, Nieuwenhuijs, Vincent B., additional, Perk, Lars, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, De Ridder, Rogier, additional, Van Santvoort, Hjalmar C., additional, Stommel, Martijn W.J., additional, Timmerhuis, Hester C., additional, Witteman, Ben, additional, Umans, Devica S., additional, Venneman, Niels G., additional, Vleggaar, Frank P., additional, Wanrooij, Roy V., additional, Sperna Weiland, Christina J., additional, Bruno, Marco J., additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2021
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25. Sa283 ENDOSCOPIC VERSUS SURGICAL STEP-UP APPROACH FOR INFECTED NECROTIZING PANCREATITIS: LONG-TERM FOLLOW-UP OF A MULTICENTER RANDOMIZED CONTROLLED TRIAL (EXTENSION)

Author

Onnekink, Anke M., primary, Boxhoorn, Lotte, additional, Bac, Simon, additional, Timmerhuis, Hester C., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas, additional, Bosscha, Koop, additional, Bouwense, Stefan A., additional, Bruno, Marco J., additional, Van Brunschot, Sandra, additional, Cappendijk, Vincent C., additional, Consten, Esther, additional, Dejong, Cornelis H., additional, Dijkgraaf, Marcel, additional, Van Eijck, Casper H., additional, Erkelens, G. Willemien, additional, van Goor, Harry, additional, van Grevenstein, Helma, additional, van Grinsven, Janneke, additional, Haveman, Jan illem, additional, Hofker, Sijbrand H., additional, Jansen, Jeroen M., additional, van Lienden, Krijn P., additional, Meijssen, Maarten, additional, Wanrooij, Roy V., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, De Ridder, Rogier, additional, Romkens, Tessa, additional, Van Santvoort, Hjalmar C., additional, Scheepers, Joris J., additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Spanier, Marcel, additional, Straathof, Jan Willem, additional, Timmer, Robin, additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Vleggaar, Frank P., additional, Witteman, Ben, additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2021
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26. Fr289 POSTPONED OR IMMEDIATE DRAINAGE OF INFECTED NECROTIZING PANCREATITIS (POINTER): A MULTICENTER RANDOMIZED TRIAL

Author

Boxhoorn, Lotte, primary, van Dijk, Sven M., additional, van Grinsven, Janneke, additional, Verdonk, Robert C., additional, Boermeester, Marja A., additional, Bollen, Thomas, additional, Bouwense, Stefan A., additional, Bruno, Marco J., additional, Cappendijk, Vincent C., additional, Dejong, Cornelis H., additional, Duijvendijk, Peter V., additional, Van Eijck, Casper H., additional, Fockens, Paul, additional, Francken, Michiel F.G., additional, van Goor, Harry, additional, Hadithi, Muhammed, additional, Hallensleben, Nora D., additional, Haveman, Jan illem, additional, Jacobs, Maarten, additional, Jansen, Jeroen M., additional, Kop, Marnix P.M., additional, van Lienden, Krijn P., additional, Manusama, Eric R., additional, Mieog, J.S., additional, Molenaar, Quintus, additional, Nieuwenhuijs, Vincent B., additional, Poen, A.C., additional, Poley, Jan-Werner, additional, van de Poll, Marcel, additional, Quispel, Rutger, additional, Romkens, Tessa E.H, additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Stommel, Martijn W.J., additional, Straathof, Jan Willem, additional, Timmerhuis, Hester C., additional, Venneman, Niels G., additional, Voermans, Rogier P., additional, Van De Vrie, W, additional, Witteman, Ben, additional, Dijkgraaf, Marcel G., additional, Van Santvoort, Hjalmar C., additional, and Besselink, Marc G., additional

Published
2021
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30. Endoscopic or surgical step-up approach for infected necrotising pancreatitis : A multicentre randomised trial

Author

van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C., Bakker, Olaf J., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A., Bruno, Marco J., Cappendijk, Vincent C., Consten, Esther C., Dejong, Cornelis H., van Eijck, Casper H., Erkelens, Willemien G., van Goor, Harry, van Grevenstein, Wilhelmina M.U., Haveman, Jan Willem, Hofker, Sijbrand H., Jansen, Jeroen M., Lame´ris, Johan S., van Lienden, Krijn P., Meijssen, Maarten A., Mulder, Chris J., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Ro¨mkens, Tessa E., Scheepers, Joris J., Schepers, Nicolien J., Schwartz, Matthijs P., Seerden, Tom, Spanier, B. W.Marcel, Straathof, Jan Willem A., Strijker, Marin, Timmer, Robin, Venneman, Niels G., Vleggaar, Frank P., Voermans, Rogier P., Witteman, Ben J., Gooszen, Hein G., Dijkgraaf, Marcel G., Fockens, Paul, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C., Bakker, Olaf J., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A., Bruno, Marco J., Cappendijk, Vincent C., Consten, Esther C., Dejong, Cornelis H., van Eijck, Casper H., Erkelens, Willemien G., van Goor, Harry, van Grevenstein, Wilhelmina M.U., Haveman, Jan Willem, Hofker, Sijbrand H., Jansen, Jeroen M., Lame´ris, Johan S., van Lienden, Krijn P., Meijssen, Maarten A., Mulder, Chris J., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Ro¨mkens, Tessa E., Scheepers, Joris J., Schepers, Nicolien J., Schwartz, Matthijs P., Seerden, Tom, Spanier, B. W.Marcel, Straathof, Jan Willem A., Strijker, Marin, Timmer, Robin, Venneman, Niels G., Vleggaar, Frank P., Voermans, Rogier P., Witteman, Ben J., Gooszen, Hein G., Dijkgraaf, Marcel G., and Fockens, Paul

Published
2018

31. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: A multicentre randomised trial

Author

MS CGO, Cancer, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C., Bakker, Olaf J., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A., Bruno, Marco J., Cappendijk, Vincent C., Consten, Esther C., Dejong, Cornelis H., van Eijck, Casper H., Erkelens, Willemien G., van Goor, Harry, van Grevenstein, Wilhelmina M.U., Haveman, Jan Willem, Hofker, Sijbrand H., Jansen, Jeroen M., Lame´ris, Johan S., van Lienden, Krijn P., Meijssen, Maarten A., Mulder, Chris J., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Ro¨mkens, Tessa E., Scheepers, Joris J., Schepers, Nicolien J., Schwartz, Matthijs P., Seerden, Tom, Spanier, B. W.Marcel, Straathof, Jan Willem A., Strijker, Marin, Timmer, Robin, Venneman, Niels G., Vleggaar, Frank P., Voermans, Rogier P., Witteman, Ben J., Gooszen, Hein G., Dijkgraaf, Marcel G., Fockens, Paul, MS CGO, Cancer, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C., Bakker, Olaf J., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A., Bruno, Marco J., Cappendijk, Vincent C., Consten, Esther C., Dejong, Cornelis H., van Eijck, Casper H., Erkelens, Willemien G., van Goor, Harry, van Grevenstein, Wilhelmina M.U., Haveman, Jan Willem, Hofker, Sijbrand H., Jansen, Jeroen M., Lame´ris, Johan S., van Lienden, Krijn P., Meijssen, Maarten A., Mulder, Chris J., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Ro¨mkens, Tessa E., Scheepers, Joris J., Schepers, Nicolien J., Schwartz, Matthijs P., Seerden, Tom, Spanier, B. W.Marcel, Straathof, Jan Willem A., Strijker, Marin, Timmer, Robin, Venneman, Niels G., Vleggaar, Frank P., Voermans, Rogier P., Witteman, Ben J., Gooszen, Hein G., Dijkgraaf, Marcel G., and Fockens, Paul

Published
2018

32. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

van Brunschot, Sandra, primary, van Grinsven, Janneke, additional, van Santvoort, Hjalmar C, additional, Bakker, Olaf J, additional, Besselink, Marc G, additional, Boermeester, Marja A, additional, Bollen, Thomas L, additional, Bosscha, Koop, additional, Bouwense, Stefan A, additional, Bruno, Marco J, additional, Cappendijk, Vincent C, additional, Consten, Esther C, additional, Dejong, Cornelis H, additional, van Eijck, Casper H, additional, Erkelens, Willemien G, additional, van Goor, Harry, additional, van Grevenstein, Wilhelmina M U, additional, Haveman, Jan-Willem, additional, Hofker, Sijbrand H, additional, Jansen, Jeroen M, additional, Laméris, Johan S, additional, van Lienden, Krijn P, additional, Meijssen, Maarten A, additional, Mulder, Chris J, additional, Nieuwenhuijs, Vincent B, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, de Ridder, Rogier J, additional, Römkens, Tessa E, additional, Scheepers, Joris J, additional, Schepers, Nicolien J, additional, Schwartz, Matthijs P, additional, Seerden, Tom, additional, Spanier, B W Marcel, additional, Straathof, Jan Willem A, additional, Strijker, Marin, additional, Timmer, Robin, additional, Venneman, Niels G, additional, Vleggaar, Frank P, additional, Voermans, Rogier P, additional, Witteman, Ben J, additional, Gooszen, Hein G, additional, Dijkgraaf, Marcel G, additional, Fockens, Paul, additional, Manusama, Eric R, additional, Hadithi, Mohammed, additional, Rosman, Camiel, additional, Schaapherder, Alexander F, additional, and Schoon, Erik J, additional

Published
2018
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33. Describing Peripancreatic Collections According to the Revised Atlanta Classification of Acute Pancreatitis

Author

Bouwense, Stefan A., primary, van Brunschot, Sandra, additional, van Santvoort, Hjalmar C., additional, Besselink, Marc G., additional, Bollen, Thomas L., additional, Bakker, Olaf J., additional, Banks, Peter A., additional, Boermeester, Marja A., additional, Cappendijk, Vincent C., additional, Carter, Ross, additional, Charnley, Richard, additional, van Eijck, Casper H., additional, Freeny, Patrick C., additional, Hermans, John J., additional, Hough, David M., additional, Johnson, Colin D., additional, Laméris, Johan S., additional, Lerch, Markus M., additional, Mayerle, Julia, additional, Mortele, Koenraad J., additional, Sarr, Michael G., additional, Stedman, Brian, additional, Vege, Santhi Swaroop, additional, Werner, Jens, additional, Dijkgraaf, Marcel G., additional, Gooszen, Hein G., additional, and Horvath, Karen D., additional

Published
2017
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34. The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis

Author

van Grinsven, Janneke, primary, van Brunschot, Sandra, additional, van Santvoort, Hjalmar C., additional, Schepers, Nicolien J., additional, Doeve, Benthe, additional, Bakker, Olaf J., additional, Bouwense, Stefan A.W., additional, Boermeester, Marja A., additional, Bollen, Thomas L., additional, Bruno, Marco J., additional, Cappendijk, Vincent C., additional, Dejong, Cornelis H.C., additional, van Eijck, Casper H.J., additional, Fockens, Paul, additional, van Goor, Harry, additional, Haveman, Jan Willem, additional, Hofker, H. Sijbrand, additional, Laméris, Johan S., additional, van Leeuwen, Maarten S., additional, van Lienden, Krijn P., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Schaapherder, Alexander F., additional, Timmer, Robin, additional, Gooszen, Hein G., additional, and Besselink, Marc G., additional

Published
2017
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35. Mo1407 The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Necrotizing Pancreatitis: A 5-Years' Experience

Author

van Grinsven, Janneke, primary, van Brunschot, Sandra, additional, Schepers, Nicolien J., additional, Doeve, Benthe, additional, Bakker, Olaf J., additional, Bouwense, Stefan A., additional, Boermeester, Marja A., additional, Bollen, Thomas L., additional, Bruno, Marco J., additional, Cappendijk, Vincent C., additional, Dejong, Cornelis C., additional, van Eijck, Casper H., additional, Fockens, Paul, additional, van Goor, Harry, additional, Haveman, Jan Willem, additional, Hofker, Sijbrand, additional, Laméris, Johan S., additional, van Leeuwen, Maarten S., additional, van Lienden, Krijn P., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Schaapherder, Alexander F., additional, Timmer, Robin, additional, Gooszen, Hein G., additional, Besselink, Marc G., additional, and van Santvoort, Hjalmar C., additional

Published
2016
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36. 534 Describing Peripancreatic Collections According to the 2013 Revised Atlanta Classification of Acute Pancreatitis: An International Interobserver Agreement Study Using the PANCODE System

Author

Bouwense, Stefan A., primary, Van Brunschot, Sandra, additional, Van Santvoort, Hjalmar C., additional, Besselink, Marc, additional, Bollen, Thomas L., additional, Bakker, Olaf J., additional, Banks, Peter A., additional, Boermeester, Marja A., additional, Cappendijk, Vincent C., additional, Carter, Ross, additional, Charnley, Richard, additional, Van Eijck, Casper H., additional, Dijkgraaf, Marcel G., additional, Freeny, Patrick C., additional, Hermans, John J., additional, Hough, David M., additional, Johnson, Colin D., additional, Lameris, J.S., additional, Lerch, Markus M., additional, Mayerle, Julia, additional, Mortele, Koenraad J., additional, Sarr, Michael G., additional, Stedman, Brian, additional, Vege, Santhi Swaroop, additional, Werner, Jens, additional, Gooszen, Hein G., additional, and Horvat, Karen, additional

Published
2014
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38. Performance of gadofosveset-enhanced MRI for staging rectal cancer nodes: can the initial promising results be reproduced?

Author

Heijnen, Luc A., primary, Lambregts, Doenja M. J., additional, Martens, Milou H., additional, Maas, Monique, additional, Bakers, Frans C. H., additional, Cappendijk, Vincent C., additional, Oliveira, Pedro, additional, Lammering, Guido, additional, Riedl, Robert G., additional, Beets, Geerard L., additional, and Beets-Tan, Regina G. H., additional

Published
2013
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39. Gadofosveset-enhanced MRI for the assessment of rectal cancer lymph nodes: predictive criteria

Author

Lambregts, Doenja M. J., primary, Heijnen, Luc A., additional, Maas, Monique, additional, Rutten, Iris J. G., additional, Martens, Milou H., additional, Backes, Walter H., additional, Riedl, Robert G., additional, Bakers, Frans C. H., additional, Cappendijk, Vincent C., additional, Beets, Geerard L., additional, and Beets-Tan, Regina G. H., additional

Published
2012
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42. Accuracy of Gadofosveset-enhanced MRI for Nodal Staging and Restaging in Rectal Cancer

Author

Lambregts, Doenja M.J., primary, Beets, Geerard L., additional, Maas, Monique, additional, Kessels, Alfons G.H., additional, Bakers, Frans C.H., additional, Cappendijk, Vincent C., additional, Engelen, Sanne M.E., additional, Lahaye, Max J., additional, de Bruïne, Adriaan P., additional, Lammering, Guido, additional, Leiner, Tim, additional, Verwoerd, Jan L., additional, Wildberger, Joachim E., additional, and Beets-Tan, Regina G.H., additional

Published
2011
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43. Absence of Tumor Invasion into Pelvic Structures in Locally Recurrent Rectal Cancer: Prediction with Preoperative MR Imaging

Author

Dresen, Raphaëla C., primary, Kusters, Miranda, additional, Daniels-Gooszen, Alette W., additional, Cappendijk, Vincent C., additional, Nieuwenhuijzen, Grard A. P., additional, Kessels, Alfons G. H., additional, de Bruïne, Adriaan P., additional, Beets, Geerard L., additional, Rutten, Harm J. T., additional, and Beets-Tan, Regina G. H., additional

Published
2010
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44. Assessment of Human Atherosclerotic Carotid Plaque Components with Multisequence MR Imaging: Initial Experience

Author

Cappendijk, Vincent C., primary, Cleutjens, Kitty B. J. M., additional, Kessels, Alfons G. H., additional, Heeneman, Sylvia, additional, Schurink, Geert Willem H., additional, Welten, Rob J. T. J., additional, Mess, Werner H., additional, Daemen, Mat J. A. P., additional, van Engelshoven, Jos M. A., additional, and Kooi, M. Eline, additional

Published
2005
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46. Transluminal endoscopic step-up approach versus minimally invasive surgical step-up approach in patients with infected necrotising pancreatitis (TENSION trial): design and rationale of a randomised controlled multicenter trial [ISRCTN09186711].

Author

van Brunschot, Sandra, van Grinsven, Janneke, Voermans, Rogier P., Bakker, Olaf J., Besselink, Marc G. H., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A., Bruno, Marco J., Cappendijk, Vincent C., Consten, Esther C., Dejong, Cornelis H., Dijkgraaf, Marcel G. W., van Eijck, Casper H., Erkelens, G. Willemien, van Goor, Harry, Hadithi, Mohammed, Haveman, Jan-Willem, and Hofker, Sijbrand H.

Subjects
RANDOMIZED controlled trials, LENGTH of stay in hospitals, LASER endoscopy, TRANSLUMINAL angioplasty, EXOCRINE glands
Abstract

Background Infected necrotising pancreatitis is a potentially lethal disease that nearly always requires intervention. Traditionally, primary open necrosectomy has been the treatment of choice. In recent years, the surgical step-up approach, consisting of percutaneous catheter drainage followed, if necessary, by (minimally invasive) surgical necrosectomy has become the standard of care. A promising minimally invasive alternative is the endoscopic transluminal step-up approach. This approach consists of endoscopic transluminal drainage followed, if necessary, by endoscopic transluminal necrosectomy. We hypothesise that the less invasive endoscopic step-up approach is superior to the surgical step-up approach in terms of clinical and economic outcomes. Methods/design The TENSION trial is a randomised controlled, parallel-group superiority multicenter trial. Patients with (suspected) infected necrotising pancreatitis with an indication for intervention and in whom both treatment modalities are deemed possible, will be randomised to either an endoscopic transluminal or a surgical step-up approach. During a 4 year study period, 98 patients will be enrolled from 24 hospitals of the Dutch Pancreatitis Study Group. The primary endpoint is a composite of death and major complications within 6 months following randomisation. Secondary endpoints include complications such as pancreaticocutaneous fistula, exocrine or endocrine pancreatic insufficiency, need for additional radiological, endoscopic or surgical intervention, the need for necrosectomy after drainage, the number of (re-)interventions, quality of life, and total direct and indirect costs. Discussion The TENSION trial will answer the question whether an endoscopic step-up approach reduces the combined primary endpoint of death and major complications, as well as hospital stay and related costs compared with a surgical step-up approach in patients with infected necrotising pancreatitis. [ABSTRACT FROM AUTHOR]

Published
2013
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48. The First Locally Acquired Human Infection of Echinococcus multilocularisin The Netherlands

Author

van Dommelen, Laura, Stoot, Jan H. M. B., Cappendijk, Vincent C., Abdul Hamid, Myrurgia A., Stelma, Foekje F., Kortbeek, Laetitia M., van der Giessen, Joke, and Oude Lashof, Astrid M. L.

Abstract

ABSTRACTIn the northern part of Western Europe, Echinococcus multilocularisis primarily detected in and spreading among foxes. The present case marks E. multilocularisas an emerging pathogen for humans, as it describes the first human case of probably locally acquired E. multilocularisin The Netherlands, with various interesting clinical aspects.

Published
2012
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49. MRI in addition to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): an international, multicentre, prospective, diagnostic accuracy trial.

Author

Görgec, Burak, Hansen, Ingrid S, Kemmerich, Gunter, Syversveen, Trygve, Abu Hilal, Mohammed, Belt, Eric J T, Bosscha, Koop, Burgmans, Mark C, Cappendijk, Vincent C, D'Hondt, Mathieu, Edwin, Bjørn, van Erkel, Arian R, Gielkens, Hugo A J, Grünhagen, Dirk J, Gobardhan, Paul D, Hartgrink, Henk H, Horsthuis, Karin, Klompenhouwer, Elisabeth G, Kok, Niels F M, and Kint, Peter A M

Subjects
*COLORECTAL liver metastasis, *CONTRAST-enhanced magnetic resonance imaging, *DIFFUSION magnetic resonance imaging, *CONTRAST media, *MAGNETIC resonance imaging
Abstract

Guidelines are inconclusive on whether contrast-enhanced MRI using gadoxetic acid and diffusion-weighted imaging should be added routinely to CT in the investigation of patients with colorectal liver metastases who are scheduled for curative liver resection or thermal ablation, or both. Although contrast-enhanced MRI is reportedly superior than contrast-enhanced CT in the detection and characterisation of colorectal liver metastases, its effect on clinical patient management is unknown. We aimed to assess the clinical effect of an additional liver contrast-enhanced MRI on local treatment plan in patients with colorectal liver metastases amenable to local treatment, based on contrast-enhanced CT. We did an international, multicentre, prospective, incremental diagnostic accuracy trial in 14 liver surgery centres in the Netherlands, Belgium, Norway, and Italy. Participants were aged 18 years or older with histological proof of colorectal cancer, a WHO performance status score of 0–4, and primary or recurrent colorectal liver metastases, who were scheduled for local therapy based on contrast-enhanced CT. All patients had contrast-enhanced CT and liver contrast-enhanced MRI including diffusion-weighted imaging and gadoxetic acid as a contrast agent before undergoing local therapy. The primary outcome was change in the local clinical treatment plan (decided by the individual clinics) on the basis of liver contrast-enhanced MRI findings, analysed in the intention-to-image population. The minimal clinically important difference in the proportion of patients who would have change in their local treatment plan due to an additional liver contrast-enhanced MRI was 10%. This study is closed and registered in the Netherlands Trial Register, NL8039. Between Dec 17, 2019, and July 31, 2021, 325 patients with colorectal liver metastases were assessed for eligibility. 298 patients were enrolled and included in the intention-to-treat population, including 177 males (59%) and 121 females (41%) with planned local therapy based on contrast-enhanced CT. A change in the local treatment plan based on liver contrast-enhanced MRI findings was observed in 92 (31%; 95% CI 26–36) of 298 patients. Changes were made for 40 patients (13%) requiring more extensive local therapy, 11 patients (4%) requiring less extensive local therapy, and 34 patients (11%) in whom the indication for curative-intent local therapy was revoked, including 26 patients (9%) with too extensive disease and eight patients (3%) with benign lesions on liver contrast-enhanced MRI (confirmed by a median follow-up of 21·0 months [IQR 17·5–24·0]). Liver contrast-enhanced MRI should be considered in all patients scheduled for local treatment for colorectal liver metastases on the basis of contrast-enhanced CT imaging. The Dutch Cancer Society and Bayer AG – Pharmaceuticals. [ABSTRACT FROM AUTHOR]

Published
2024
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50. The first locally acquired human infection of Echinococcus multilocularis in The Netherlands.

Author

van Dommelen L, Stoot JH, Cappendijk VC, Abdul Hamid MA, Stelma FF, Kortbeek LM, van der Giessen J, and Oude Lashof AM

Subjects
Animals, Echinococcosis parasitology, Echinococcosis pathology, Echinococcus multilocularis genetics, Female, Histocytochemistry, Humans, Liver parasitology, Liver pathology, Microscopy, Middle Aged, Netherlands, Radiography, Abdominal, Sequence Analysis, DNA, Tomography, X-Ray Computed, Echinococcosis diagnosis, Echinococcus multilocularis isolation & purification
Abstract

In the northern part of Western Europe, Echinococcus multilocularis is primarily detected in and spreading among foxes. The present case marks E. multilocularis as an emerging pathogen for humans, as it describes the first human case of probably locally acquired E. multilocularis in The Netherlands, with various interesting clinical aspects.

Published
2012
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