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1. Treating Aortic Valve Stenosis for Vitality Improvement: The TAVI Study.

Author

Tartaglione, Donato, Prozzo, Dario, Bianchi, Renatomaria, Ciccarelli, Giovanni, Cappelli Bigazzi, Maurizio, Natale, Francesco, Golino, Paolo, and Cimmino, Giovanni

Subjects
HEART valve prosthesis implantation, AORTIC stenosis, HEART valve diseases, AORTIC valve transplantation, ALZHEIMER'S disease, TRANSCRANIAL Doppler ultrasonography, CEREBRAL circulation
Abstract

Background: Degenerative aortic valve stenosis (AS) is the most common valvular heart disease among the elderly. Once cardiac symptoms occur, current guidelines recommend aortic valve replacement. Progressive degeneration/calcification reduces leaflet mobility with gradual cardiac output (CO) impairment. Low CO might induce abnormal brain-aging with cognitive impairment and increased risk of dementia, such as Alzheimer's disease or vascular dementia. On the contrary, cognitive improvement has been reported in patients in whom CO was restored. Transcatheter aortic valve implantation (TAVI) has proven to be a safe alternative to conventional surgery, with a similar mid-term survival and stroke risk even in low-risk patients. TAVI is associated with an immediate CO improvement, also effecting the cerebrovascular system, leading to an increased cerebral blood flow. The correlation between TAVI and cognitive improvement is still debated. The present study aims at evaluating this relationship in a cohort of AS patients where cognitive assessment before and after TAVI was available. Methods: a total of 47 patients were retrospectively selected. A transcranial Doppler ultrasound (TCD) before and after TAVI, a quality of life (QoL) score, as well as a mini-mental state examination (MMSE) at baseline and up to 36 months, were available. Results: TAVI was associated with immediate increase in mean cerebral flow at TCD. MMSE slowly increase at 36-months follow-up with improved QoL mainly for symptoms, emotions and social interactions. Conclusions: this proof-of-concept study indicates that TAVI might induce cognitive improvement in the long-term as a result of multiple factors, such as cerebral flow restoration and a better QoL. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Predictive Value of Left Ventricular Myocardial Deformation for Left Ventricular Remodeling in Patients With Classical Low-Flow, Low-Gradient Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement

Author

D'Andrea, Antonello, Carbone, Andreina, Agricola, Eustachio, Riegler, Lucia, Sperlongano, Simona, Tocci, Giampaolo, Scarafile, Raffaella, Formisano, Tiziana, Capogrosso, Cristina, Cappelli Bigazzi, Maurizio, Bossone, Eduardo, Galderisi, Maurizio, and Golino, Paolo

Published
2019
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4. Population Trends in Rates of Percutaneous Coronary Revascularization for Acute Coronary Syndromes Associated With the COVID-19 Outbreak

Author

Piccolo, Raffaele, Bruzzese, Dario, Mauro, Ciro, Aloia, Antonio, Baldi, Cesare, Boccalatte, Marco, Bottiglieri, Giuseppe, Briguori, Carlo, Caiazzo, Gianluca, Calabrò, Paolo, Cappelli-Bigazzi, Maurizio, De Simone, Ciro, Di Lorenzo, Emilio, Golino, Paolo, Monda, Vittorio, Perrotta, Rocco, Quaranta, Gaetano, Russolillo, Enrico, Scherillo, Marino, Tesorio, Tullio, Tuccillo, Bernardino, Valva, Giuseppe, Villari, Bruno, Tarantini, Giuseppe, Varricchio, Attilio, and Esposito, Giovanni

Published
2020
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6. Advances in Percutaneous Patent Foramen Ovale Closure: From the Procedure to the Echocardiographic Guidance

Author

Sperlongano, Simona, primary, Giordano, Mario, additional, Ciccarelli, Giovanni, additional, Bassi, Giuseppe, additional, Malvezzi Caracciolo D’Aquino, Marco, additional, Del Giudice, Carmen, additional, Gaio, Gianpiero, additional, D’Andrea, Antonello, additional, Postolache, Adriana, additional, Cappelli Bigazzi, Maurizio, additional, Scognamiglio, Giancarlo, additional, Sarubbi, Berardo, additional, Russo, Maria Giovanna, additional, Golino, Paolo, additional, and Lancellotti, Patrizio, additional

Published
2022
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8. Safety and feasibility of balloon aortic valvuloplasty in non-TAVI centers: The 'BAV for life' experience

Author

Attisano, Tiziana, Silverio, Angelo, Stabile, Eugenio, Briguori, Carlo, Tuccillo, Bernardino, Scotto Di Uccio, Fortunato, Di Lorenzo, Emilio, Tesorio, Tullio, Giordano, Arturo, Calabrò, Paolo, Cappelli Bigazzi, Maurizio, Golino, Paolo, Scherillo, Marino, Vigorito, Francesco, Quaranta, Gaetano, Esposito, Giovanni, Mauro, Ciro, Musumeci, Giuseppe, Tarantini, Giuseppe, Galasso, Gennaro, Venuti, Angela, Maione, Antongiulio, Accadia, Maria, Spadaro, Pasquale, Arnese, Maria Rosaria, Pastore, Fabio, Eusebio, Giuseppina, De Angelis, Maria Carmen, Varricchio, Attilio, Alfieri, Alfonso, Di Girolamo, Domenico, Bianchi, Renato Maria, Visconti, Gabriella, Ambrosini, Vittorio, Capasso, Michele, Formigli, Dario, Villari, Bruno, De Simone, Ciro, Manganiello, Vincenzo, Attisano, Tiziana, Silverio, Angelo, Stabile, Eugenio, Briguori, Carlo, Tuccillo, Bernardino, Scotto Di Uccio, Fortunato, Di Lorenzo, Emilio, Tesorio, Tullio, Giordano, Arturo, Calabrò, Paolo, Cappelli Bigazzi, Maurizio, Golino, Paolo, Scherillo, Marino, Vigorito, Francesco, Quaranta, Gaetano, Esposito, Giovanni, Mauro, Ciro, Musumeci, Giuseppe, Tarantini, Giuseppe, Galasso, Gennaro, Venuti, Angela, Maione, Antongiulio, Accadia, Maria, Spadaro, Pasquale, Arnese, Maria Rosaria, Pastore, Fabio, Eusebio, Giuseppina, De Angelis, Maria Carmen, Varricchio, Attilio, Alfieri, Alfonso, Di Girolamo, Domenico, Bianchi, Renato Maria, Visconti, Gabriella, Ambrosini, Vittorio, Capasso, Michele, Formigli, Dario, Villari, Bruno, De Simone, Ciro, and Manganiello, Vincenzo

Subjects
Balloon Valvuloplasty, Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, 030204 cardiovascular system & hematology, Balloon, Group B, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Nuclear Medicine and Imaging, Internal medicine, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Hospital Mortality, Prospective Studies, aortic stenosis, balloon aortic valvuloplasty, transcatheter aortic valve implantation, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, 030212 general & internal medicine, Aged, Training period, Aged, 80 and over, Ejection fraction, business.industry, Cardiogenic shock, Aortic Valve Stenosis, Recovery of Function, General Medicine, aortic stenosi, medicine.disease, Aortic valvuloplasty, Treatment Outcome, Italy, Aortic valve stenosis, Heart failure, Cardiology, Feasibility Studies, Female, Radiology, business
Abstract

Objectives To evaluate the safety and the feasibility of balloon aortic valvuloplasty (BAV) procedure made by trained operators in centers not performing transcatheter aortic valve implantation (TAVI). Background BAV is a valuable therapeutic tool for patients with symptomatic severe aortic valve stenosis (AS) at prohibitive risk for TAVI or surgery. Methods Consecutive high-risk AS patients underwent BAV in five non-TAVI centers, where BAV operators had completed a 6-month training period in high-volume TAVI centers (Group A). All clinical, echocardiographic, and procedural data were prospectively collected and compared with data of patients treated in TAVI center (Group B). Results Between June 2016 and June 2017, 55 patients (83.9 ± 7.0 years) were enrolled: 25 in Group A and 30 in Group B. After BAV, a substantial reduction of the peak-to-peak aortic valve gradient was obtained in both groups (-35.3 ± 15.2 vs -28.8 ± 13.9 mmHg, P =0.25). No major bleeding or vascular complications occurred. In-hospital death was observed in three patients of Group A and two patients of Group B (P =0.493). The mean follow-up time was 303 ± 188 days; no patients were lost. The 1-year survival free from overall death (Group A 75.8% vs Group B 68.8%; P =0.682) and heart failure rehospitalization (Group A 73.0% vs Group B 66.8%; P =0.687) was similar in the two groups. At multivariable analysis, low left ventricular (LV) ejection fraction (HR: 0.943; P = 0.011) and cardiogenic shock (HR: 5.128; P = 0.002) at admission were independent predictors of mortality. Conclusions BAV is a safe and effective procedure that can be performed by trained operators in centers not performing TAVI.

Published
2018
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13. [Updated SICI-GISE position paper on institutional and operator requirements for transcatheter aortic valve implantation]

Author

Tarantini, Giuseppe, Esposito, Giovanni, Musumeci, Giuseppe, Fraccaro, Chiara, Franzone, Anna, Castiglioni, Battistina, La Manna, Alessio, Limbruno, Ugo, Marchese, Alfredo, Mauro, Ciro, Rigattieri, Stefano, Tarantino, Fabio, Gandolfo, Caterina, Santoro, Gennaro, Violini, Roberto, Airoldi, Flavio, Albiero, Remo, Balbi, Manrico, Baralis, Giorgio, Bartorelli, Antonio Luca, Bedogni, Francesco, Benassi, Alberto, Berni, Andrea, Bonzani, Giulio, Bortone, Alessandro Santo, Braito, Giuseppe, Briguori, Carlo, Brscic, Elvis, Calabrò, Paolo, Calchera, Ivan, Cappelli Bigazzi, Maurizio, Caprioglio, Francesco, Castriota, Fausto, Cernetti, Carlo, Cicala, Cinzia, Cioffi, Paolo, Colombo, Antonio, Colombo, Virgilio, Contegiacomo, Gaetano, Cremonesi, Alberto, D'Amico, Maurizio, De Benedictis, Mauro, De Leo, Alessandro, Di Biasi, Maurizio, Di Girolamo, Domenico, Di Lorenzo, Emilio, Di Mario, Carlo, Dominici, Marcello, Ettori, Federica, Ferrario, Maurizio, Fioranelli, Massimo, Fischetti, Dionigi, Gabrielli, Gabriele, Giordano, Arturo, Giudice, Pietro, Greco, Cesare, Indolfi, Ciro, Leonzi, Ornella, Lettieri, Corrado, Loi, Bruno, Maddestra, Nicola, Marchionni, Niccolò, Marrozzini, Cinzia, Medda, Massimo, Missiroli, Bindo, My, Luigi, Oreglia, Jacopo Andrea, Palmieri, Cataldo, Pantaleo, Paolo, Paparoni, Saro Roberto, Parodi, Guido, Petronio, Anna Sonia, Piatti, Luigi, Piccaluga, Emanuela, Pierli, Carlo, Perkan, Andrea, Pitì, Antonino, Poli, Arnaldo, Ramondo, Angelo Bruno, Reale, Maurizio Alessandro, Reimers, Bernhard, Ribichini, Flavio Luciano, Rosso, Roberta, Saccà, Salvatore, Sacra, Cosimo, Santarelli, Andrea, Sardella, Gennaro, Satullo, Gaetano, Scalise, Filippo, Siviglia, Massimo, Spedicato, Leonardo, Stabile, Amerigo, Tamburino, Corrado, Tesorio, Tullio Nicola Maria, Tolaro, Salvatore, Tomai, Fabrizio, Trani, Carlo, Valenti, Renato, Valsecchi, Orazio, Valva, Giuseppe, Varbella, Ferdinando, Vigna, Carlo, Vignali, Luigi, Berti, Sergio, Tarantini, Giuseppe, Esposito, Giovanni, Musumeci, Giuseppe, Fraccaro, Chiara, Franzone, Anna, Castiglioni, Battistina, La Manna, Alessio, Limbruno, Ugo, Marchese, Alfredo, Mauro, Ciro, Rigattieri, Stefano, Tarantino, Fabio, Gandolfo, Caterina, Santoro, Gennaro, Violini, Roberto, Airoldi, Flavio, Albiero, Remo, Balbi, Manrico, Baralis, Giorgio, Bartorelli, Antonio Luca, Bedogni, Francesco, Benassi, Alberto, Berni, Andrea, Bonzani, Giulio, Bortone, Alessandro Santo, Braito, Giuseppe, Briguori, Carlo, Brscic, Elvi, Calabrò, Paolo, Calchera, Ivan, Cappelli Bigazzi, Maurizio, Caprioglio, Francesco, Castriota, Fausto, Cernetti, Carlo, Cicala, Cinzia, Cioffi, Paolo, Colombo, Antonio, Colombo, Virgilio, Contegiacomo, Gaetano, Cremonesi, Alberto, D'Amico, Maurizio, De Benedictis, Mauro, De Leo, Alessandro, Di Biasi, Maurizio, Di Girolamo, Domenico, Di Lorenzo, Emilio, Di Mario, Carlo, Dominici, Marcello, Ettori, Federica, Ferrario, Maurizio, Fioranelli, Massimo, Fischetti, Dionigi, Gabrielli, Gabriele, Giordano, Arturo, Giudice, Pietro, Greco, Cesare, Indolfi, Ciro, Leonzi, Ornella, Lettieri, Corrado, Loi, Bruno, Maddestra, Nicola, Marchionni, Niccolò, Marrozzini, Cinzia, Medda, Massimo, Missiroli, Bindo, My, Luigi, Oreglia, Jacopo Andrea, Palmieri, Cataldo, Pantaleo, Paolo, Paparoni, Saro Roberto, Parodi, Guido, Petronio, Anna Sonia, Piatti, Luigi, Piccaluga, Emanuela, Pierli, Carlo, Perkan, Andrea, Pitì, Antonino, Poli, Arnaldo, Ramondo, Angelo Bruno, Reale, Maurizio Alessandro, Reimers, Bernhard, Ribichini, Flavio Luciano, Rosso, Roberta, Saccà, Salvatore, Sacra, Cosimo, Santarelli, Andrea, Sardella, Gennaro, Satullo, Gaetano, Scalise, Filippo, Siviglia, Massimo, Spedicato, Leonardo, Stabile, Amerigo, Tamburino, Corrado, Tesorio, Tullio Nicola Maria, Tolaro, Salvatore, Tomai, Fabrizio, Trani, Carlo, Valenti, Renato, Valsecchi, Orazio, Valva, Giuseppe, Varbella, Ferdinando, Vigna, Carlo, Vignali, Luigi, and Berti, Sergio

Subjects
Transcatheter aortic valve implantation, Transcatheter aortic valve implantation, TAVI, severe aortic stenosis, Operators, Biomedical Technology, Requirements, Aortic Valve Stenosis, Institutions, Severity of Illness Index, Transcatheter Aortic Valve Replacement, TAVI, Italy, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Training, Humans, Program Development, severe aortic stenosis
Abstract

Transcatheter aortic valve implantation (TAVI) has revolutionized the management of patients with symptomatic severe aortic stenosis and has become the standard of care for inoperable patients and the preferred therapy for those at increased surgical risk with peculiar clinical and anatomic features. Technology advances, growing experience and accumulating data prompted the update of the 2011 Italian Society of Interventional Cardiology (SICI-GISE) position paper on institutional and operator requirements to perform TAVI. The main objective of this document is to provide a guidance to assess the potential of institutions and operators to initiate and maintain an efficient TAVI program.

Published
2018

15. Ceruloplasmin impairs endothelium-dependent relaxation of rabbit aorta

Author

Cappelli-Bigazzi, Maurizio, Ambrosio, Giuseppe, Musci, Giovanni, Battaglia, Carmine, Di Patti, Maria Carmela Bonaccorsi, Golino, Paolo, Ragni, Massimo, Chiariello, Massimo, and Calabrese, Lilia

Subjects
Vasodilators -- Research, Endothelium-derived relaxing factors -- Research, Vascular endothelium -- Research, Biological sciences
Abstract

Research suggests that endothelium-dependent vasodilation is impacted by plasma protein ceruloplasmin. Experiments using rabbit aorta rings in the presence of endothelial nitric oxide are described. Vasorelaxation measurements are illustrated for rabbit thoracic aorta tissue in the presence of biochemicals such as acetylcholine and nitroglycerin. Further research is required to define ceruloplasmin's physiological role in greater detail.

Published
1997

18. Local effect of serotonin released during coronary angioplasty

Author

Golino, Paolo, Piscione, Federico, Benedict, Claude R., Anderson, H. Vernon, Cappelli-Bigazzi, Maurizio, Indolfi, Ciro, Condorelli, Mario, Chiariello, Massimo, and Willerson, James T.

Subjects
Serotonin -- Physiological aspects, Transluminal angioplasty -- Physiological aspects
Abstract

Serotonin appears to be released during coronary angioplasty and may play a part in blood vessel constriction that occurs in the segment of the artery farthest from the surgery site. Coronary angioplasty is a method of dilating a blocked blood vessel in the heart. Serotonin is a blood vessel constrictor found in blood platelets. Blood samples were taken from 15 patients having coronary angioplasty. Seven of the patients also received ketanserin, which inhibits the action of serotonin. Serotonin levels before surgery averaged 2.3 nanograms per milliliter (ng/ml) in the coronary sinus, a venous channel in the heart, and 2.5 ng/ml in the ascending aorta. Serotonin concentrations in the ascending aorta did not change during surgery. However, serotonin levels increased significantly in the coronary sinus. In the patients not treated with ketanserin, dilation of the segment of the artery farthest from the angioplasty site decreased by 23% after five minutes. In those treated with ketanserin, constriction of the arterial segment farthest from the angioplasty site occurred but to a lesser degree than in those patients not given ketanserin.

Published
1994

19. Multi-step percutaneous treatment of post-myocardial infarction ventricular septal defects: A case report and review of literature

Author

Moscarella, Elisabetta, Santoro, Giuseppe, Gaio, Gianpiero, Palladino, Teresa, D'Aiello, Angelo Fabio, Mahmoud, Heba Talat, Cappelli Bigazzi, Maurizio, Russo, Maria Giovanna, Moscarella, Elisabetta, Santoro, Giuseppe, Gaio, Gianpiero, Palladino, Teresa, D'Aiello, Angelo Fabio, Mahmoud, Heba Talat, Cappelli Bigazzi, Maurizio, and Russo, Maria Giovanna

Subjects
Heart Septal Defects, Ventricular, Prosthesis Implantation, Myocardial infarction, Septal Occluder Device, Ventricular septal rupture, Female, Middle Aged, Human
Abstract

Post-myocardial infarction (MI) ventricular septal defects (VSD) are a rare but life-threatening complication of acute MI, with very high mortality rates even if timely approached by surgical repair. Transcatheter closure is an attractive alternative to surgery. However, this option is currently deemed challenging and often unsuitable in complex VSD. We report the case of a young woman in poor hemodynamic conditions due to a complex post-MI VSD. A two-step percutaneous VSD closure was successfully performed adopting a patient-tailored approach based on a throughout knowledge of the anatomic and functional picture using both commercially available dedicated and off-label devices.

Published
2017

21. Effects of intravenous verapamil on left ventricular relaxation and filling in stable angina pectoris

Author

Betocchi, Sandro, Piscione, Federico, Perrone-Filardi, Pasquale, Pace, Leonardo, Cappelli-Bigazzi, Maurizio, Alfano, Bruno, Ciarmiello, Andrea, Salvatore, Marco, Condorelli, Mario, and Chiariello, Massimo

Subjects
Calcium channel blockers -- Physiological aspects, Heart failure -- Causes of, Angina pectoris -- Drug therapy, Heart ventricle, Left -- Physiological aspects, Verapamil -- Physiological aspects, Health
Abstract

Left ventricular (LV) diastolic function is often impaired in coronary artery disease (CAD). To assess whether verapamil could improve LV diastolic properties, 12 patients with CAD undergoing right-and left-sided cardiac catheterization, as well as simultaneous radionuclide angiography, were studied before and during intravenous administration of verapamil (0.1 mg/kg as a bolus followed by 0.007 mg/kg/min). The heart rate was kept constant by atrial pacing in both studies. LV pressure-volume relations were obtained. Verapamil decreased LV systolic pressure (130 [+ or -] 22 to 117 [+ or -] 16 mm Hg, p (Am J Cardiol 1990;66:818-825), Left ventricular (LV) diastolic function refers to the relaxation phase of the heartbeat, specifically when the left atrium contracts and oxygenated blood flows into the relaxed LV chamber. Angina pectoris (chest pain caused by decreased blood flow to the heart) can impair this function by slowing ventricular relaxation and reducing early filling of the LV. This diastolic dysfunction may induce symptoms of congestive heart failure even when ventricular systolic function (the ability to pump oxygenated blood into the systemic circulation) is normal. The authors investigated whether treatment with verapamil, a calcium channel blocker usually used to treat angina, would reverse diastolic dysfunction. Verapamil is known to improve LV relaxation and filling for some conditions, and noninvasive studies had reported similar effects in patients with coronary artery disease (CAD). It was important to determine whether verapamil-related improvements in LV relaxation and filling were the result of improved diastolic function or increased filling pressure. Twelve patients with CAD, who were undergoing diagnostic heart catheterization and angiography (X-ray), were studied before and during intravenous administration of verapamil. When measurements were being taken, the heart rate was kept constant by a cardiac pacemaker. Comparison with a control group was not possible because healthy people could not be subjected to such invasive procedures. The results of the study indicate that administration of verapamil is useful in treating coronary artery disease. Its effects on the myocardium, or heart muscle, improved LV relaxation and, thereby, increased the peak filling rate. Verapamil also led to a higher preload, resulting in enhanced filling, and reduced afterload, resulting in improved relaxation. Therefore, verapamil affects LV function and early filling as a result of both direct action on the heart muscle and changes in load. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

22. Safety and feasibility of balloon aortic valvuloplasty in non‐TAVI centers: The "BAV for life" experience.

Author

Attisano, Tiziana, Silverio, Angelo, Stabile, Eugenio, Briguori, Carlo, Tuccillo, Bernardino, Scotto Di Uccio, Fortunato, Di Lorenzo, Emilio, Tesorio, Tullio, Giordano, Arturo, Calabrò, Paolo, Cappelli Bigazzi, Maurizio, Golino, Paolo, Scherillo, Marino, Vigorito, Francesco, Quaranta, Gaetano, Esposito, Giovanni, Mauro, Ciro, Musumeci, Giuseppe, Tarantini, Giuseppe, and Galasso, Gennaro

Published
2019
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23. From Femoral to Radial Approach in Coronary Intervention

Author

Bianchi, Renatomaria, primary, D’Acierno, Ludovica, additional, Crisci, Mario, additional, Tartaglione, Donato, additional, Cappelli Bigazzi, Maurizio, additional, Canonico, Mario, additional, Albanese, Michele, additional, Gragnano, Felice, additional, Fimiani, Fabio, additional, Russo, Mariagiovanna, additional, Cirillo, Plinio, additional, and Calabrò, Paolo, additional

Published
2016
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25. From Femoral to Radial Approach in Coronary Intervention.

Author

Bianchi, Renatomaria, D’Acierno, Ludovica, Crisci, Mario, Tartaglione, Donato, Cappelli Bigazzi, Maurizio, Canonico, Mario, Albanese, Michele, Gragnano, Felice, Fimiani, Fabio, Russo, Mariagiovanna, Cirillo, Plinio, and Calabrò, Paolo

Subjects
CARDIAC catheterization, CONFIDENCE intervals, COST effectiveness, FEMORAL artery, EVALUATION of medical care, PATIENT safety, SURGICAL complications, RETROSPECTIVE studies, RADIAL artery, DESCRIPTIVE statistics, CORONARY angiography
Abstract

Since the first cardiac catheterization in 1929, this procedure has evolved considerably. Historically performed via the transfemoral access, in the last years, the transradial access has been spreading gradually due to its many advantages. We have conducted a review of published literature concerning efficacy, safety, and cost-effectiveness, and we analyzed our patients’ data, including the results of the recently published Minimizing Adverse hemorrhagic events by TRansradial access site and systemic implementation of angioX (MATRIX) study. This review confirmed the superiority of the transradial access compared to the femoral access, especially regarding complications related to the access site, duration of hospitalization, and comfort for the patient. The transradial approach is an excellent option for coronary angiography, and the procedure’s risks are reduced by increased operator experience. [ABSTRACT FROM AUTHOR]

Published
2017
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26. Effects of Transcatheter Aortic Valve Implantation on Left Ventricular and Left Atrial Morphology and Function

Author

D'Andrea, Antonello, primary, Padalino, Roberto, additional, Cocchia, Rosangela, additional, Di Palma, Enza, additional, Riegler, Lucia, additional, Scarafile, Raffaella, additional, Rossi, Giovanni, additional, Bianchi, Renato, additional, Tartaglione, Donato, additional, Cappelli Bigazzi, Maurizio, additional, Calabrò, Paolo, additional, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Calabrò, Raffaele, additional, and Russo, Maria Giovanna, additional

Published
2014
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27. Effects of Transcatheter Aortic Valve Implantation on Left Ventricular and Left Atrial Morphology and Function.

Author

D'Andrea, Antonello, Padalino, Roberto, Cocchia, Rosangela, Di Palma, Enza, Riegler, Lucia, Scarafile, Raffaella, Rossi, Giovanni, Bianchi, Renato, Tartaglione, Donato, Cappelli Bigazzi, Maurizio, Calabrò, Paolo, Citro, Rodolfo, Bossone, Eduardo, Calabrò, Raffaele, and Russo, Maria Giovanna

Subjects
ANALYSIS of variance, AORTIC stenosis, CONFIDENCE intervals, STATISTICAL correlation, ENDOSCOPIC surgery, PROSTHETIC heart valves, LONGITUDINAL method, REGRESSION analysis, STATISTICS, T-test (Statistics), DATA analysis, DATA analysis software, DESCRIPTIVE statistics, MULTIDETECTOR computed tomography
Abstract

Aims Transcatheter aortic valve implantation ( TAVI) is an alternative treatment in surgically high-risk or inoperable patients with severe aortic stenosis ( AS). The objective of this study was to analyze the effects of TAVI on left ventricular ( LV) and left atrial ( LA) longitudinal function assessed by speckle tracking echocardiography (2 DSTE) in patients with AS. Methods In our prospectively conducted study, a total of 55 symptomatic ( New York Heart Association class II or higher) patients with severe AS, considered to be at increased risk for undergoing surgical aortic valve replacement, were recruited (age: 78.6 ± 7.4 year). Patients underwent a complete clinical and laboratory evaluation, in addition to standard echocardiography and 2 DSTE. Echocardiographic analysis was performed before and 6 months after TAVI. 2 DSTE measured segmental and global longitudinal strain ( GLS) and radial strain. Results All the patients received the CoreValve self-expanding prosthesis. Six months after TAVI, patients showed a significant reduction in mean transaortic gradient (52.1 ± 15.8 vs. 11.2 ± 3.3 mmHg, P < 0.0001), LV mass, LA volume index, and an improvement of ejection fraction (P < 0.0001). In addition, LV GLS (−11.8 ± 3.2 vs. −16.3 ± 4.2%; P < 0.0001) and LA longitudinal strain (14.2 ± 5.4 vs. 26.6 ± 10.8%, P < 0.0001) significantly increased after TAVI. In a stepwise forward multiple logistic regression analysis, LV mass before TAVI (P < 0.001) and peak CK MB mass after TAVI (P < 0.0001) were powerful independent predictors of lower improvement of LV GLS. Moreover, LV mass index (P < 0.001) and LV GLS strain (P < 0.001) before TAVI were powerful independent predictor of LA longitudinal strain after TAVI Conclusions TAVI in patients with AS resulted in geometric changes known as 'reverse remodelling,' and improved LV and LA function assessed by 2 DSTE. [ABSTRACT FROM AUTHOR]

Published
2015
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29. Endothelial cell function in patients with Down's syndrome

Author

Cappelli-Bigazzi, Maurizio, primary, Santoro, Giuseppe, additional, Battaglia, Carmine, additional, Palladino, Maria Teresa, additional, Carrozza, Marianna, additional, Russo, Maria Giovanna, additional, Pacileo, Giuseppe, additional, and Calabrò, Raffaele, additional

Published
2004
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31. Effects of Diltiazem on Left Ventricular Systolic and Diastolic Function in Hypertrophic Cardiomyopathy**This study was supported in part by Grant 18/1/57 1994–1995 from the Italian Ministry of University and Scientific Research (MURST 60%), Rome, Italy.

Author

Betocchi, Sandro, primary, Piscione, Federico, additional, Losi, Maria-Angela, additional, Pace, Leonardo, additional, Boccalatte, Marco, additional, Perrone-Filardi, Pasquale, additional, Cappelli-Bigazzi, Maurizio, additional, Briguori, Carlo, additional, Manganelli, Fiore, additional, Ciampi, Quirino, additional, Salvatore, Marco, additional, and Chiariello, Massimo, additional

Published
1996
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34. Asymptomatic Stroke in the Setting of Percutaneous Non-Coronary Intervention Procedures.

Author

Ciccarelli, Giovanni, Renon, Francesca, Bianchi, Renato, Tartaglione, Donato, Cappelli Bigazzi, Maurizio, Loffredo, Francesco, Golino, Paolo, and Cimmino, Giovanni

Subjects
STROKE patients, ATRIAL fibrillation, SURVIVAL rate, CARDIOVASCULAR diseases, HEART failure
Abstract

Advancements in clinical management, pharmacological therapy and interventional procedures have strongly improved the survival rate for cardiovascular diseases (CVDs). Nevertheless, the patients affected by CVDs are more often elderly and present several comorbidities such as atrial fibrillation, valvular heart disease, heart failure, and chronic coronary syndrome. Standard treatments are frequently not available for "frail patients", in particular due to high surgical risk or drug interaction. In the past decades, novel less-invasive procedures such as transcatheter aortic valve implantation (TAVI), MitraClip or left atrial appendage occlusion have been proposed to treat CVD patients who are not candidates for standard procedures. These procedures have been confirmed to be effective and safe compared to conventional surgery, and symptomatic thromboembolic stroke represents a rare complication. However, while the peri-procedural risk of symptomatic stroke is low, several studies highlight the presence of a high number of silent ischemic brain lesions occurring mainly in areas with a low clinical impact. The silent brain damage could cause neuropsychological deficits or worse, a preexisting dementia, suggesting the need to systematically evaluate the impact of these procedures on neurological function. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Effects of high cholesterol and atherogenic diets on vascular relaxation in spontaneously...

Author

Cappelli-Bigazzi, Maurizio and Rubattu, Speranza

Subjects
*HYPERCHOLESTEREMIA, *HYPERTENSION, *BLOOD-vessel physiology, *PHYSIOLOGY
Abstract

Explores the role of hypercholesterolemia and hypertension on vascular function. High cholesterol diet (ChD) in spontaneously hypertensive rats (SHR); Maximal relaxation of isolated vessels to acetylcholine (Ach), adenosine phosphate (ADP) and nitroglycerin; Atherogenic diet (AD)in SHR.

Published
1997
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47. Advances in Percutaneous Patent Foramen Ovale Closure: From the Procedure to the Echocardiographic Guidance

Author

Simona Sperlongano, Mario Giordano, Giovanni Ciccarelli, Giuseppe Bassi, Marco Malvezzi Caracciolo D’Aquino, Carmen Del Giudice, Gianpiero Gaio, Antonello D’Andrea, Adriana Postolache, Maurizio Cappelli Bigazzi, Giancarlo Scognamiglio, Berardo Sarubbi, Maria Giovanna Russo, Paolo Golino, Patrizio Lancellotti, Sperlongano, Simona, Giordano, Mario, Ciccarelli, Giovanni, Bassi, Giuseppe, Malvezzi Caracciolo D'Aquino, Marco, Del Giudice, Carmen, Gaio, Gianpiero, D'Andrea, Antonello, Postolache, Adriana, Cappelli Bigazzi, Maurizio, Scognamiglio, Giancarlo, Sarubbi, Berardo, Russo, Maria Giovanna, Golino, Paolo, and Lancellotti, Patrizio

Subjects
Gore Cardioform Septal Occluder, intracardiac echocardiography (ICE), Amplatzer PFO Occluder, transesophageal echocardiography (TEE), General Medicine, NobleStitch, patent foramen ovale (PFO)
Abstract

Percutaneous patent foramen ovale (PFO) closure by traditional, double disc occluder devices was shown to be safe for patients with PFO, and more effective than prolonged medical therapy in preventing recurrent thromboembolic events. The novel suture-mediated “deviceless” PFO closure system overcomes most of the risks and limitations associated with the traditional PFO occluders, appearing to be feasible in most interatrial septum anatomies, even if data about its long-term effectiveness and safety are still lacking. The aim of the present review was to provide to the reader the state of the art about the traditional and newer techniques of PFO closure, focusing both on the procedural aspects and on the pivotal role of transesophageal echocardiography (TEE) in patient’s selection, peri-procedural guidance, and post-interventional follow-up.

Published
2022

48. Percutaneous Left Atrial Appendage Occlusion: An Emerging Option in Patients with Atrial Fibrillation at High Risk of Bleeding

Author

Dario Prozzo, Paolo Golino, Emanuele Gallinoro, Francesco Loffredo, Luigi Colucci Cante, Maurizio Cappelli Bigazzi, Giovanni Cimmino, Gemma Salerno, Dario Fabiani, Cimmino, Giovanni, Loffredo, Francesco S, Gallinoro, Emanuele, Prozzo, Dario, Fabiani, Dario, Cante, Luigi, Salerno, Gemma, Cappelli Bigazzi, Maurizio, and Golino, Paolo

Subjects
medicine.medical_specialty, Medicine (General), Percutaneous, left atrial appendage occlusion, medicine.medical_treatment, Population, Femoral vein, Ischemia, Hemorrhage, Review, Left atrial appendage occlusion, R5-920, bleeding risk, Internal medicine, Atrial Fibrillation, Medicine, Humans, Atrial Appendage, Embolization, Thrombus, education, education.field_of_study, business.industry, Anticoagulant, Anticoagulants, Atrial fibrillation, General Medicine, cardioembolism, medicine.disease, Europe, Stroke, Treatment Outcome, Cardiology, stroke prevention, business, Human
Abstract

Atrial fibrillation (AF) is a common cardiac arrhythmia with an estimated prevalence of 1% in the general population. It is associated with an increased risk of ischemic stroke, silent cerebral ischemia, and cognitive impairment. Due to the blood flow stasis and morphology, thrombus formation occurs mainly in the left atrial appendage (LAA), particularly in the setting of nonvalvular AF (NVAF). Previous studies have shown that >90% of emboli related to NVAF originate from the LAA, thus prevention of systemic cardioembolism is indicated. According to the current guidelines, anticoagulant therapy with direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs), represents the standard of care in AF patients, in order to prevent ischemic stroke and peripheral embolization. Although these drugs are widely used and DOACs have shown, compared to VKAs, non-inferiority for stroke prevention with significantly fewer bleeding complications, some issues remain a matter of debate, including contraindications, side effects, and adherence. An increasing number of patients, indeed, because of high bleeding risk or after experiencing life-threatening bleedings, must take anticoagulants with extreme caution if not contraindicated. While surgical closure or exclusion of LAA has been historically used in patients with AF with contradictory results, in the recent years, a novel procedure has emerged to prevent the cardioembolic stroke in these patients: The percutaneous left atrial appendage occlusion (LAAO). Different devices have been developed in recent years, though not all of them are approved in Europe and some are still under clinical investigation. Currently available devices have shown a significant decrease in bleeding risk while maintaining efficacy in preventing thromboembolism. The procedure can be performed percutaneously through the femoral vein access, under general anesthesia. A transseptal puncture is required to access left atrium and is guided by transesophageal echocardiography (TEE). Evidence from the current literature indicates that percutaneous LAAO represents a safe alternative for those patients with contraindications for long-term oral anticoagulation. This review summarizes scientific evidences regarding LAAO for stroke prevention including clinical indications and an adequate patient selection.

Published
2021

49. Population Trends in Rates of Percutaneous Coronary Revascularization for Acute Coronary Syndromes Associated with the COVID-19 Outbreak

Author

Raffaele Piccolo, Dario Bruzzese, Ciro Mauro, Antonio Aloia, Cesare Baldi, Marco Boccalatte, Giuseppe Bottiglieri, Carlo Briguori, Gianluca Caiazzo, Paolo Calabrò, Maurizio Cappelli-Bigazzi, Ciro De Simone, Emilio Di Lorenzo, Paolo Golino, Vittorio Monda, Rocco Perrotta, Gaetano Quaranta, Enrico Russolillo, Marino Scherillo, Tullio Tesorio, Bernardino Tuccillo, Giuseppe Valva, Bruno Villari, Giuseppe Tarantini, Attilio Varricchio, Giovanni Esposito, Marisa Avvedimento, Renato Maria Bianchi, Stefano Capobianco, Gerardo Carpinella, Mario Crisci, Luca Esposito, Luciano Fattore, Luigi Fimiani, Dario Formigli, Marco Golino, Eugenio Laurenzano, Attilio Leone, Fabio Magliulo, Tullio Niglio, Roberto Padalino, Fabio Pastore, Federica Serino, Fortunato Scotto Di Uccio, Gabriella Visconti, Piccolo, Raffaele, Bruzzese, Dario, Mauro, Ciro, Aloia, Antonio, Baldi, Cesare, Boccalatte, Marco, Bottiglieri, Giuseppe, Briguori, Carlo, Caiazzo, Gianluca, Calabrò, Paolo, Cappelli-Bigazzi, Maurizio, De Simone, Ciro, Di Lorenzo, Emilio, Golino, Paolo, Monda, Vittorio, Perrotta, Rocco, Quaranta, Gaetano, Russolillo, Enrico, Scherillo, Marino, Tesorio, Tullio, Tuccillo, Bernardino, Valva, Giuseppe, Villari, Bruno, Tarantini, Giuseppe, Varricchio, Attilio, and Esposito, Giovanni

Subjects
Acute coronary syndrome, medicine.medical_specialty, Percutaneous, medicine.medical_treatment, Population, Disease Outbreaks, acute coronary syndrome, Betacoronavirus, Physiology (medical), Pandemic, Epidemiology, Correspondence, Research Letter, Humans, Medicine, Viral, education, Pandemics, education.field_of_study, biology, business.industry, SARS-CoV-2, percutaneous coronary intervention, Outbreak, Percutaneous coronary intervention, COVID-19, Acute Coronary Syndrome, Coronavirus Infections, Percutaneous Coronary Intervention, Pneumonia, Viral, Population Surveillance, Pneumonia, biology.organism_classification, medicine.disease, Emergency medicine, epidemiology, Cardiology and Cardiovascular Medicine, business
Published
2020

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