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1. Third national surgical consensus conference of the Italian Association of Breast Surgeons (ANISC) on management after neoadjuvant chemotherapy: The difficulty in reaching a consensus

Author

Zanotti, Simone, Ceccarossi, Virginia, Massaza, Lauretta, Cosentino, Luigi Marino, Amaturo, Giuseppe, Curcio, Annalisa, Bondioli, Paola, Meattini, Icro, Luca, Alessandro De, Garcia-Etienne, Carlos Alberto, Gala, Antonia, Thodas, Alexios, Lozupone, Antonia, Botticella, Maria Antonietta, Grassi, Massimo, Santoro, Valeria, Ala, Ada, Tessa, Cristina La, D'onghia, Giuliano, Carfora, Elisabetta, Cappelli, Sonia, Nunzi, Martina, Mastropietro, Tiziana, Meneghini, Graziano, Morichetti, Doriana, Sanna, Paola Angela, Pozzi, Giada, Soatti, Carlo Pietro, Pellegrini, Alba, Puccica, Ilaria, Frati, Sara, Leone, Alba Di, Giuliani, Giuliana, Conte, Anna Maria, Zamagni, Claudio, Seriau, Luca, Minischetti, Monica, Foroni, Moira, Valli, Mariacarla, Lippi, Andrea, Ravarino, Alberto, Giaccherini, Lucia, Calzolaro, Adele, Neri, Anna, Carli, Luciano, Mambelli, Laura, Prisco, Agnese, Di Marzio, Enrico, Venturini, Annalisa, Gattuso, Maria Ilaria, Sicignano, Margherita, Amabile, Maria Ida, Baldissera, Antonella, Sibilio, Andrea, Chiavilli, Stefano, Gennari, Roberto, Melina, Marica, D'aponte, Maria Luisa, Germano, Alessandro, Baldoni, Giulia, Santurro, Letizia, Busani, Massimo, Bonanni, Alessio, Tondo, Salvatore, Marchetti, Vania, Cassinotti, Michela, Serra, Margherita, Stani, Simonetta, Firpo, Emma, Grendele, Sara, Spolveri, Federico, Custodero, Olindo, Pellegrini, Francesco, Cremonini, Anna, De Tullio, Damiano, Sorbo, Grazia, Combi, Francesca, Aristei, Cynthia, Roncella, Manuela, Folli, Secondo, Nesi, Silvia, Gentile, Damiano, Burlizzi, Stefano, Galimberti, Viviana, Trapani, Anna, Curella, Luciano, Panizza, Pietro, Nanez, Jose Andres Diaz, Sgarella, Adele, Pensa, Anna, Gasperoni, Marco, Marino, Lorenza, Marzetti, Alice, De Rosa, Antonia, Borri, Filippo, Camilletti, Anna Chiara, Ruggieri, Annamaria, Andrulli, Angela Damiana, Silvia, Asioli, Terribile, Daniela Andreina, Accardo, Giuseppe, Patrone, Francesco, Raviele, Paola Rafaniello, Santini, Donatella, Costarelli, Leopoldo, Angelini, Lucia, Reitano, Renato, Polistena, Andrea, Palma, Enza, Santoni, Marcello, Magni, Carla, Cima, Simona, Foglietta, Jennifer, Minafra, Marina, Rizzo, Antonio, Milanesio, Michela Camilla, Giorgini, Sara, Grossi, Simona, Cumbo, Jacopo, Campanella, Barbara, Fante, Rossella, Pinta, Massimo La, Manna, Elena, Santini, Elena, Mascioni, Francesca, Teggi, Silvia, Galasso, Maria Grazia, Sanguinetti, Alessandro, Fenocchio, Daniela, Giacobbe, Felicia, Pellegrini, Alice, Papi, Simona, Pieroni, Marzia, Villa, Elisa, Querzoli, Patrizia, Guadagno, Elia, Perfetti, Alessandra, Balzarotti, Laura, Ciriotto, Davide, Guida, Giovanna, Canova, Elisa, Lunardi, Maria, Vignutelli, Patrizia, Apicella, Giuseppina, Natale, Maria, Ghilli, Matteo, Troilo, Vito Leopoldo, Rocco, Nicola, Schiavone, Alfonso, Ventimiglia, Fabrizio, Zarba Meli, Emanuele, Taffurelli, Mario, Caruso, Francesco, Gentilini, Oreste Davide, Del Mastro, Lucia, Livi, Lorenzo, Castellano, Isabella, Bernardi, Daniela, Minelli, Mauro, and Fortunato, Lucio

Published
2024
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2. HER2 mutation as an emerging target in advanced breast cancer

Author

Bon, Giulia, primary, Di Lisa, Francesca Sofia, additional, Filomeno, Lorena, additional, Arcuri, Teresa, additional, Krasniqi, Eriseld, additional, Pizzuti, Laura, additional, Barba, Maddalena, additional, Messina, Beatrice, additional, Schiavoni, Giulia, additional, Sanguineti, Giuseppe, additional, Botti, Claudio, additional, Cappelli, Sonia, additional, Pelle, Fabio, additional, Cavicchi, Flavia, additional, Puccica, Ilaria, additional, Costantini, Maurizio, additional, Perracchio, Letizia, additional, Maugeri‐Saccà, Marcello, additional, Ciliberto, Gennaro, additional, and Vici, Patrizia, additional

Published
2024
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4. DNA Damage Response in Early Breast Cancer: A Phase III Cohort in the Phobos Study.

Author

Krasniqi, Eriseld, Ercolani, Cristiana, Di Benedetto, Anna, Di Lisa, Francesca Sofia, Filomeno, Lorena, Arcuri, Teresa, Botti, Claudio, Pelle, Fabio, Cavicchi, Flavia, Cappelli, Sonia, Barba, Maddalena, Pizzuti, Laura, Maugeri-Saccà, Marcello, Moscetti, Luca, Grassadonia, Antonino, Tinari, Nicola, Sanguineti, Giuseppe, Takanen, Silvia, Fragnito, Davide, and Terrenato, Irene

Subjects
BREAST tumor treatment, LYMPH nodes, DOCETAXEL, RESEARCH funding, EARLY detection of cancer, HYDROCARBONS, DNA, TUMOR markers, CELLULAR signal transduction, ATAXIA telangiectasia, LONGITUDINAL method, IMMUNOHISTOCHEMISTRY, GENE expression, PHOSPHOPROTEINS, CYCLOPHOSPHAMIDE
Abstract

Simple Summary: This study evaluates DDR biomarkers in 222 node-positive early breast cancer patients from a Phase III trial on adjuvant taxanes. Over a 234-month follow-up period, no differences in DFS or OS were observed between treatment groups. However, a DDR risk score, influenced by ATM and ATR expression, proved to be an independent prognostic factor for both DFS and OS. Validation in a public cohort confirmed ATM's protective role. These findings highlight the importance of DDR pathways in breast cancer prognostication and support, integrating molecular markers with clinical–pathological factors to inform treatment strategies. We assessed the impact of DNA damage response and repair (DDR) biomarker expressions in 222 node-positive early breast cancer (BC) patients from a previous Phase III GOIM 9902 trial of adjuvant taxanes. At a median follow-up of 64 months, the original study showed no disease-free survival (DFS) or overall survival (OS) differences with the addition of docetaxel (D) to epirubicine-cyclophosphamide (EC). Immunohistochemistry was employed to assess the expression of DDR phosphoproteins (pATM, pATR, pCHK1, γH2AX, pRPA32, and pWEE1) in tumor tissue, and their association with clinical outcomes was evaluated through the Cox elastic net model. Over an extended follow-up of 234 months, we confirmed no significant differences in DFS or OS between patients treated with EC and those receiving D → EC. A DDR risk score, inversely driven by ATM and ATR expression, emerged as an independent prognostic factor for both DFS (HR = 0.41, p < 0.0001) and OS (HR = 0.61, p = 0.046). Further validation in a public adjuvant BC cohort was possible only for ATM, confirming its protective role. Overall, our findings confirm the potential role of the DDR pathway in BC prognostication and in shaping treatment strategies advocating for an integrated approach, combining molecular markers with clinical–pathological factors. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Roux-en-Y Gastric Bypass after Laparoscopic Sleeve Gastrectomy Failure: Could the Number of Previous Operations Influence the Outcome?

Author

Sista, Federico, primary, Carandina, Sergio, additional, Soprani, Antoine, additional, Rivkine, Emmanuel, additional, Montana, Laura, additional, Fiasca, Fabiana, additional, Cappelli, Sonia, additional, Grasso, Antonella, additional, Nedelcu, Marius, additional, Tucceri Cimini, Irene, additional, and Clementi, Marco, additional

Published
2024
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6. Adjuvant capecitabine in triple negative breast cancer patients with residual disease after neoadjuvant treatment: real-world evidence from CaRe, a multicentric, observational study

Author

Di Lisa, Francesca Sofia, primary, Krasniqi, Eriseld, additional, Pizzuti, Laura, additional, Barba, Maddalena, additional, Cannita, Katia, additional, De Giorgi, Ugo, additional, Borella, Fulvio, additional, Foglietta, Jennifer, additional, Cariello, Anna, additional, Ferro, Antonella, additional, Picardo, Elisa, additional, Mitidieri, Marco, additional, Sini, Valentina, additional, Stani, Simonetta, additional, Tonini, Giuseppe, additional, Santini, Daniele, additional, La Verde, Nicla, additional, Gambaro, Anna Rita, additional, Grassadonia, Antonino, additional, Tinari, Nicola, additional, Garrone, Ornella, additional, Sarobba, Giuseppina, additional, Livi, Lorenzo, additional, Meattini, Icro, additional, D’Auria, Giuliana, additional, Vergati, Matteo, additional, Gamucci, Teresa, additional, Pistelli, Mirco, additional, Berardi, Rossana, additional, Risi, Emanuela, additional, Giotta, Francesco, additional, Lorusso, Vito, additional, Rinaldi, Lucia, additional, Artale, Salvatore, additional, Cazzaniga, Marina Elena, additional, Zustovich, Fable, additional, Cappuzzo, Federico, additional, Landi, Lorenza, additional, Torrisi, Rosalba, additional, Scagnoli, Simone, additional, Botticelli, Andrea, additional, Michelotti, Andrea, additional, Fratini, Beatrice, additional, Saltarelli, Rosa, additional, Paris, Ida, additional, Muratore, Margherita, additional, Cassano, Alessandra, additional, Gianni, Lorenzo, additional, Gaspari, Valeria, additional, Veltri, Enzo Maria, additional, Zoratto, Federica, additional, Fiorio, Elena, additional, Fabbri, Maria Agnese, additional, Mazzotta, Marco, additional, Ruggeri, Enzo Maria, additional, Pedersini, Rebecca, additional, Valerio, Maria Rosaria, additional, Filomeno, Lorena, additional, Minelli, Mauro, additional, Scavina, Paola, additional, Raffaele, Mimma, additional, Astone, Antonio, additional, De Vita, Roy, additional, Pozzi, Marcello, additional, Riccardi, Ferdinando, additional, Greco, Filippo, additional, Moscetti, Luca, additional, Giordano, Monica, additional, Maugeri-Saccà, Marcello, additional, Zennaro, Alessandro, additional, Botti, Claudio, additional, Pelle, Fabio, additional, Cappelli, Sonia, additional, Cavicchi, Flavia, additional, Vizza, Enrico, additional, Sanguineti, Giuseppe, additional, Tomao, Federica, additional, Cortesi, Enrico, additional, Marchetti, Paolo, additional, Tomao, Silverio, additional, Speranza, Iolanda, additional, Sperduti, Isabella, additional, Ciliberto, Gennaro, additional, and Vici, Patrizia, additional

Published
2023
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7. Breast cancer surgery during the Covid-19 pandemic: a monocentre experience from the Regina Elena National Cancer Institute of Rome

Author

Pelle, Fabio, Cappelli, Sonia, Graziano, Franco, Piarulli, Loredana, Cavicchi, Flavia, Magagnano, Domenico, De Luca, Assunta, De Vita, Roy, Pozzi, Marcello, Costantini, Maurizio, Varanese, Antonio, Panimolle, Massimo, Gullo, Pietro Paolo, Barba, Maddalena, Vici, Patrizia, Vizza, Enrico, Cognetti, Francesco, Sanguineti, Giuseppe, Saracca, Elena, Ciliberto, Gennaro, and Botti, Claudio

Published
2020
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9. The Impact of the Hippo Pathway and Cell Metabolism on Pathological Complete Response in Locally Advanced Her2+ Breast Cancer: The TRISKELE Multicenter Prospective Study

Author

Krasniqi, Eriseld, primary, Di Lisa, Francesca Sofia, additional, Di Benedetto, Anna, additional, Barba, Maddalena, additional, Pizzuti, Laura, additional, Filomeno, Lorena, additional, Ercolani, Cristiana, additional, Tinari, Nicola, additional, Grassadonia, Antonino, additional, Santini, Daniele, additional, Minelli, Mauro, additional, Montemurro, Filippo, additional, Fabbri, Maria Agnese, additional, Mazzotta, Marco, additional, Gamucci, Teresa, additional, D’Auria, Giuliana, additional, Botti, Claudio, additional, Pelle, Fabio, additional, Cavicchi, Flavia, additional, Cappelli, Sonia, additional, Cappuzzo, Federico, additional, Sanguineti, Giuseppe, additional, Tomao, Silverio, additional, Botticelli, Andrea, additional, Marchetti, Paolo, additional, Maugeri-Saccà, Marcello, additional, De Maria, Ruggero, additional, Ciliberto, Gennaro, additional, Sperati, Francesca, additional, and Vici, Patrizia, additional

Published
2022
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10. Colostomy Reversal following Hartmann’s Procedure: The Importance of Timing in Short- and Long-Term Complications: A Retrospective Multicentric Study

Author

Clementi, Marco, primary, Pietroletti, Renato, additional, Carletti, Filippo, additional, Sista, Federico, additional, Grasso, Antonella, additional, Fiasca, Fabiana, additional, Cappelli, Sonia, additional, Balla, Andrea, additional, Rizza, Vinicio, additional, Ciarrocchi, Andrea, additional, and Guadagni, Stefano, additional

Published
2022
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11. Surgical site infections in patients undergoing breast oncological surgery during the lockdown: An unexpected lesson from the COVID-19 pandemic

Author

Cappelli, Sonia, primary, Corallino, Diletta, additional, Clementi, Marco, additional, Guadagni, Stefano, additional, Pelle, Fabio, additional, Puccica, Ilaria, additional, Barba, Maddalena, additional, Vici, Patrizia, additional, Sperduti, Isabella, additional, Costantini, Maurizio, additional, and Botti, Claudio, additional

Published
2022
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12. Reverse strategy to locally advanced breast implantassociated anaplastic large cell lymphoma: A case report.

Author

Cappelli, Sonia, Marchesi, Francesco, Clementi, Marco, Perracchio, Letizia, Palombi, Francesca, Pelle, Fabio, Botti, Claudio, and Costantini, Maurizio

Subjects
ANAPLASTIC large-cell lymphoma, STEM cell transplantation, BREAST implants, HEMATOPOIETIC stem cells, T-cell lymphoma
Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoma associated with textured breast implants. The most common presentation is a periprosthetic seroma that occurs at least 1 year after an aesthetic or reconstructive implantation, and in these cases, the surgical treatment seems to be successful. More rarely, BIA-ALCL presents with locally advanced mass-formed disease and a related regional lymph node involvement. In all these cases with worse prognosis, a multidisciplinary approach is required, including adjuvant chemotherapy, radiation therapy, and surgery. We present a clinical case of a 49-year-old woman who developed on the left side of the breast a mass-formed stage 3 BIA-ALCL 15 years after a bilateral breast augmentation with textured silicone implant. Our multidisciplinary team (MDT) scheduled the patient for a "reverse-strategy" sequential approach consisting of induction chemotherapy, hematopoietic stem cell mobilization, and harvest followed by autologous stem cell transplant (ASCT). After 100 days from the stem cell transplant, the patient showed a complete pathologic response and was a candidate for radical surgery. She underwent removal of both implants with total en bloc capsulectomy. On the left site, the periprosthetic mass was also en bloc removed. We did not perform any axillary dissection. Our surgical and hemato-oncological teams followed the patient every 3 months, and no local or systemic recurrences were observed 24 months after surgery. This case report has demonstrated the effectiveness of neoadjuvant chemotherapy as part of a "reverse strategy" in selected cases of advanced-stage BIA-ALCL in which it was not possible to perform an immediate radical surgery. Furthermore, in our case, the de-escalation strategy adopted permitted a less demolitic surgery with good functional and aesthetic results. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Role of Chemotherapy in Vulvar Cancers: Time to Rethink Standard of Care?

Author

Mazzotta, Marco, primary, Pizzuti, Laura, additional, Krasniqi, Eriseld, additional, Di Lisa, Francesca Sofia, additional, Cappuzzo, Federico, additional, Landi, Lorenza, additional, Sergi, Domenico, additional, Pelle, Fabio, additional, Cappelli, Sonia, additional, Botti, Claudio, additional, Vizza, Enrico, additional, Tomao, Silverio, additional, Marchetti, Luca, additional, Sanguineti, Giuseppe, additional, Botticelli, Andrea, additional, Marchetti, Paolo, additional, Magri, Valentina, additional, Pisegna, Simona, additional, Venuti, Aldo, additional, Tomao, Federica, additional, Buzzacchino, Federica, additional, Ciliberto, Gennaro, additional, Barba, Maddalena, additional, and Vici, Patrizia, additional

Published
2021
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14. Surgical Site Infections in Breast Cancer Patients Undergoing Surgery During the Covid-19 Pandemic. Preliminary Data from an Italian Oncologic Hub.

Author

Cappelli, Sonia, primary, Pelle, Fabio, additional, Clementi, Marco, additional, Barba, Maddalena, additional, Vici, Patrizia, additional, Capomolla, Elisabetta, additional, Pizzuti, Laura, additional, Corallino, Diletta, additional, Sperduti, Isabella, additional, Graziano, Franco, additional, Piarulli, Loredana, additional, Cavicchi, Flavia, additional, Magagnano, Domenico, additional, De vita, Roy, additional, Quercia, Vittorio, additional, Pozzi, Marcello, additional, Costantini, Maurizio, additional, Ciliberto, Gennaro, additional, and Botti, Claudio, additional

Published
2021
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15. sj-docx-1-tam-10.1177_17588359211059873 ��� Supplemental material for PANHER study: a 20-year treatment outcome analysis from a multicentre observational study of HER2-positive advanced breast cancer patients from the real-world setting

Author

Pizzuti, Laura, Krasniqi, Eriseld, Sperduti, Isabella, Barba, Maddalena, Gamucci, Teresa, Mauri, Maria, Veltri, Enzo Maria, Meattini, Icro, Berardi, Rossana, Di Lisa, Francesca Sofia, Natoli, Clara, Pistelli, Mirco, Iezzi, Laura, Risi, Emanuela, D���Ostilio, Nicola, Tomao, Silverio, Ficorella, Corrado, Cannita, Katia, Riccardi, Ferdinando, Cassano, Alessandra, Bria, Emilio, Fabbri, Maria Agnese, Mazzotta, Marco, Barchiesi, Giacomo, Botticelli, Andrea, D���Auria, Giuliana, Ceribelli, Anna, Michelotti, Andrea, Russo, Antonio, Salimbeni, Beatrice Taurelli, Sarobba, Giuseppina, Giotta, Francesco, Paris, Ida, Saltarelli, Rosa, Marinelli, Daniele, Corsi, Domenico, Capomolla, Elisabetta Maria, Sini, Valentina, Moscetti, Luca, Mentuccia, Lucia, Tonini, Giuseppe, Raffaele, Mimma, Marchetti, Luca, Minelli, Mauro, Ruggeri, Enzo Maria, Scavina, Paola, Bacciu, Olivia, Salesi, Nello, Livi, Lorenzo, Tinari, Nicola, Grassadonia, Antonino, Fedele Scinto, Angelo, Rossi, Rosalinda, Valerio, Maria Rosaria, Landucci, Elisabetta, Stani, Simonetta, Fratini, Beatrice, Maugeri-Sacc��, Marcello, De Tursi, Michele, Maione, Angela, Santini, Daniele, Orlandi, Armando, Lorusso, Vito, Cortesi, Enrico, Sanguineti, Giuseppe, Pinnar��, Paola, Cappuzzo, Federico, Landi, Lorenza, Botti, Claudio, Tomao, Federica, Cappelli, Sonia, Bon, Giulia, Pelle, Fabio, Cavicchi, Flavia, Fiorio, Elena, Foglietta, Jennifer, Scagnoli, Simone, Marchetti, Paolo, Ciliberto, Gennaro, and Vici, Patrizia

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tam-10.1177_17588359211059873 for PANHER study: a 20-year treatment outcome analysis from a multicentre observational study of HER2-positive advanced breast cancer patients from the real-world setting by Laura Pizzuti, Eriseld Krasniqi, Isabella Sperduti, Maddalena Barba, Teresa Gamucci, Maria Mauri, Enzo Maria Veltri, Icro Meattini, Rossana Berardi, Francesca Sofia Di Lisa, Clara Natoli, Mirco Pistelli, Laura Iezzi, Emanuela Risi, Nicola D���Ostilio, Silverio Tomao, Corrado Ficorella, Katia Cannita, Ferdinando Riccardi, Alessandra Cassano, Emilio Bria, Maria Agnese Fabbri, Marco Mazzotta, Giacomo Barchiesi, Andrea Botticelli, Giuliana D���Auria, Anna Ceribelli, Andrea Michelotti, Antonio Russo, Beatrice Taurelli Salimbeni, Giuseppina Sarobba, Francesco Giotta, Ida Paris, Rosa Saltarelli, Daniele Marinelli, Domenico Corsi, Elisabetta Maria Capomolla, Valentina Sini, Luca Moscetti, Lucia Mentuccia, Giuseppe Tonini, Mimma Raffaele, Luca Marchetti, Mauro Minelli, Enzo Maria Ruggeri, Paola Scavina, Olivia Bacciu, Nello Salesi, Lorenzo Livi, Nicola Tinari, Antonino Grassadonia, Angelo Fedele Scinto, Rosalinda Rossi, Maria Rosaria Valerio, Elisabetta Landucci, Simonetta Stani, Beatrice Fratini, Marcello Maugeri-Sacc��, Michele De Tursi, Angela Maione, Daniele Santini, Armando Orlandi, Vito Lorusso, Enrico Cortesi, Giuseppe Sanguineti, Paola Pinnar��, Federico Cappuzzo, Lorenza Landi, Claudio Botti, Federica Tomao, Sonia Cappelli, Giulia Bon, Fabio Pelle, Flavia Cavicchi, Elena Fiorio, Jennifer Foglietta, Simone Scagnoli, Paolo Marchetti, Gennaro Ciliberto and Patrizia Vici in Therapeutic Advances in Medical Oncology

Published
2021
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16. PANHER study: a 20-year treatment outcome analysis from a multicentre observational study of HER2-positive advanced breast cancer patients from the real-world setting

Author

Pizzuti, Laura, primary, Krasniqi, Eriseld, additional, Sperduti, Isabella, additional, Barba, Maddalena, additional, Gamucci, Teresa, additional, Mauri, Maria, additional, Veltri, Enzo Maria, additional, Meattini, Icro, additional, Berardi, Rossana, additional, Di Lisa, Francesca Sofia, additional, Natoli, Clara, additional, Pistelli, Mirco, additional, Iezzi, Laura, additional, Risi, Emanuela, additional, D’Ostilio, Nicola, additional, Tomao, Silverio, additional, Ficorella, Corrado, additional, Cannita, Katia, additional, Riccardi, Ferdinando, additional, Cassano, Alessandra, additional, Bria, Emilio, additional, Fabbri, Maria Agnese, additional, Mazzotta, Marco, additional, Barchiesi, Giacomo, additional, Botticelli, Andrea, additional, D’Auria, Giuliana, additional, Ceribelli, Anna, additional, Michelotti, Andrea, additional, Russo, Antonio, additional, Salimbeni, Beatrice Taurelli, additional, Sarobba, Giuseppina, additional, Giotta, Francesco, additional, Paris, Ida, additional, Saltarelli, Rosa, additional, Marinelli, Daniele, additional, Corsi, Domenico, additional, Capomolla, Elisabetta Maria, additional, Sini, Valentina, additional, Moscetti, Luca, additional, Mentuccia, Lucia, additional, Tonini, Giuseppe, additional, Raffaele, Mimma, additional, Marchetti, Luca, additional, Minelli, Mauro, additional, Ruggeri, Enzo Maria, additional, Scavina, Paola, additional, Bacciu, Olivia, additional, Salesi, Nello, additional, Livi, Lorenzo, additional, Tinari, Nicola, additional, Grassadonia, Antonino, additional, Fedele Scinto, Angelo, additional, Rossi, Rosalinda, additional, Valerio, Maria Rosaria, additional, Landucci, Elisabetta, additional, Stani, Simonetta, additional, Fratini, Beatrice, additional, Maugeri-Saccà, Marcello, additional, De Tursi, Michele, additional, Maione, Angela, additional, Santini, Daniele, additional, Orlandi, Armando, additional, Lorusso, Vito, additional, Cortesi, Enrico, additional, Sanguineti, Giuseppe, additional, Pinnarò, Paola, additional, Cappuzzo, Federico, additional, Landi, Lorenza, additional, Botti, Claudio, additional, Tomao, Federica, additional, Cappelli, Sonia, additional, Bon, Giulia, additional, Pelle, Fabio, additional, Cavicchi, Flavia, additional, Fiorio, Elena, additional, Foglietta, Jennifer, additional, Scagnoli, Simone, additional, Marchetti, Paolo, additional, Ciliberto, Gennaro, additional, and Vici, Patrizia, additional

Published
2021
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19. [Intestinal and systemic endotoxaemia after laparotomic or laparoscopic cholecystectomy].

Author

Schietroma M, Cappelli S, Carlei F, Di Giuro G, Agnifili A, Recchia CL, Antonellis M, and Amicucci G

Subjects
Adult, Aged, Cholecystectomy adverse effects, Cholecystectomy methods, Female, Humans, Intestinal Diseases microbiology, Male, Middle Aged, Prospective Studies, Cholecystectomy, Laparoscopic adverse effects, Endotoxemia etiology, Intestinal Diseases etiology, Laparotomy adverse effects
Abstract

Since laparoscopic cholecystectomy (LC) is widely recognised as being a "mild" or minimally invasive kind surgery, the aim of this prospective non-randomised study was to investigate the effect of intestinal manipulation on intestinal permeability and endotoxaemia in patients undergoing elective cholecystectomy, comparing the laparoscopic and laparotomic approaches. The intestine is susceptible to operations at remote locations, and the barrier function is altered during intestinal manipulation, leading to bacterial or endotoxin translocation into the systemic circulation. Fifty-three patients undergoing elective cholecystectomy were divided into two groups on the basis of laparotomic (n = 27) or laparoscopic (n = 26) approach. Intestinal permeability was measured preoperatively, and on day 1 and day 3 after surgery using the lactulose/mannitol absorption test. Serial venous samples were taken at 0, 30, 60, 90, 120 and 180 minutes, and at 12, 24 and 48 hours after surgery, for endotoxin measurement using the chromogenic limulus amoebocyte lysate assay. Intestinal permeability was significantly increased on day 1 [0.106 +/- 0.0005 (mean +/- S.E.M.)] in the laparotomic group compared to the preoperative level (0.019 +/- 0.005, p < 0.05) and to the laparoscopic group on day 1 (0.019 +/- 0.005, p < 0.05) which showed no change in comparison with the preoperative level. A significantly higher concentration of systemic endotoxin was detected intraoperatively in the laparotomic group of patients in comparison with the laparoscopic group (p < 0.05). There was significant positive correlation between systemic endotoxaemia and intestinal permeability (rs = 0.958; p = 0.001). An increase in intestinal permeability and degree of systemic endotoxaemia are observed during laparotomic cholecystectomy. This suggets that intestinal manipulation may impair the mucosal barrier function of the gut and contribute to the systemic inflammatory response seen in open cholecystectomy.

Published
2006

20. [Acute abdomen: emergency laparoscopy or observation?].

Author

Schietroma M, Cappelli S, Carlei F, and Amicucci G

Subjects
Abdomen, Acute diagnosis, Abdomen, Acute epidemiology, Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Child, Preschool, Female, Humans, Italy epidemiology, Male, Middle Aged, Prospective Studies, Abdomen, Acute surgery, Emergency Treatment, Laparoscopy
Abstract

Acute abdomen accounts for 13-40% of all emergency surgical admissions. The aim of this prospective randomised controlled study was to examine the role of early laparoscopy in the management of acute abdomen compared with the more traditional active observation approach. From July 1993 to August 2004, 522 patients consecutively admitted with acute abdomen were randomised to either early laparoscopy (260 patients) (group 1) or active observation and non-invasive investigation (262 patients) (group 2). Baseline investigations included a full blood count, a pregnancy test in women of child-bearing age, and chest and/or abdominal radiography, if indicated clinically. Sixty-two patients in the laparoscopy group underwent a total of 116 radiological investigations compared with a total of 558 investigations in all patients in the observation group (p < 0.05). In the observation group, 34.7% of patients remained without a clear diagnosis compared with 4.2% of patients in the early laparoscopy group (p < 0.0001). The morbidity rate was 1.1% in group 1 and 27% in group 2 (p < 0.0001). The duration of hospital stay was significantly shorter in group 1 (3.1 vs 7.3 days) (p < 0.01). Eight patients in group 1 required readmission (total readmission: 46 days) compared with 58 patients in group 2 with a total readmission of 201 days (p < 0.05). Early laparoscopy is valuable in the management of acute abdomen. It affords significantly higher diagnostic accuracy and a greater improvement in quality of life than the more traditional observation approach.

Published
2005

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