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1,257 results on '"Cappa, Stefano F."'

1. Itel MMSE: a short phone screening test for cognitive decline. Italian Validation study by the SINdem Neuropsychology Working Group

Author

Quaranta, Davide, L’Abbate, Federica, Pelosi, Annalisa, Arighi, Andrea, Asoni, Gesuina, Bagattini, Chiara, Bessi, Valentina, Bonanni, Laura, Bortoletto, Marta, Bruni, Amalia Cecilia, Cagnin, Annachiara, Cappa, Stefano F., Giubilei, Franco, Guarino, Maria, Iavarone, Alessandro, Isella, Valeria, Luca, Antonina, Monastero, Roberto, Pellegrini, Francesca Ferrari, Perini, Marta, Piccoli, Tommaso, Rainero, Innocenzo, Tedeschi, Gioacchino, Marra, Camillo, and Caffarra, Paolo

Published
2024
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4. Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study

Author

Santi, Gaia Chiara, Conca, Francesca, Esposito, Valentina, Polito, Cristina, Caminiti, Silvia Paola, Boccalini, Cecilia, Morinelli, Carmen, Berti, Valentina, Mazzeo, Salvatore, Bessi, Valentina, Marcone, Alessandra, Iannaccone, Sandro, Kim, Se-Kang, Sorbi, Sandro, Perani, Daniela, Cappa, Stefano F., and Catricalà, Eleonora

Published
2024
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5. A digital teleneuropsychology platform for the diagnosis of mild cognitive impairment: from concept to certification as a medical device

Author

Panzavolta, Andrea, Cerami, Chiara, Caffarra, Paolo, De Vita, Dalila, Dodich, Alessandra, Fonti, Cristina, L’Abbate, Federica, Laganà, Valentina, Lavorgna, Luigi, Marra, Camillo, Papagno, Costanza, Pellegrini, Francesca Ferrari, Stracciari, Andrea, Trojano, Luigi, Iaquinta, Tiziana, Ravizza, Alice, Sternini, Federico, Pandolfi, Roberta, Sanzone, Sveva, Calore, Monica, and Cappa, Stefano F.

Published
2024
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6. Correction to: A digital teleneuropsychology platform for the diagnosis of mild cognitive impairment: from concept to certification as a medical device

Author

Panzavolta, Andrea, Cerami, Chiara, Caffarra, Paolo, De Vita, Dalila, Dodich, Alessandra, Fonti, Cristina, L’Abbate, Federica, Laganà, Valentina, Lavorgna, Luigi, Marra, Camillo, Papagno, Costanza, Pellegrini, Francesca Ferrari, Stracciari, Andrea, Trojano, Luigi, Iaquinta, Tiziana, Ravizza, Alice, Sternini, Federico, Pandolfi, Roberta, Sanzone, Sveva, Calore, Monica, and Cappa, Stefano F.

Published
2024
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7. Outcome measures for Alzheimer's disease: A global inter‐societal Delphi consensus

Author

Ellison, Tim S, Cappa, Stefano F, Garrett, Dawne, Georges, Jean, Iwatsubo, Takeshi, Kramer, Joel H, Lehmann, Maryna, Lyketsos, Constantine, Maier, Andrea B, Merrilees, Jennifer, Morris, John C, Naismith, Sharon L, Nobili, Flavio, Pahor, Marco, Pond, Dimity, Robinson, Louise, Soysal, Pinar, Vandenbulcke, Mathieu, Weber, Christopher J, Visser, Pieter Jelle, Weiner, Michael, and Frisoni, Giovanni B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Psychology, Brain Disorders, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Alzheimer's Disease, Bioengineering, Neurodegenerative, Neurosciences, Behavioral and Social Science, Aging, Dementia, 8.4 Research design and methodologies (health services), Neurological, Humans, Alzheimer Disease, Quality of Life, Consensus, Delphi Technique, Outcome Assessment, Health Care, Alzheimer's disease, consensus, Delphi, dementia, measures, outcomes, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome.MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria.ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes.DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

Published
2023

8. European intersocietal recommendations for the biomarker-based diagnosis of neurocognitive disorders

Author

Frisoni, Giovanni B, Festari, Cristina, Massa, Federico, Cotta Ramusino, Matteo, Orini, Stefania, Aarsland, Dag, Agosta, Federica, Babiloni, Claudio, Borroni, Barbara, Cappa, Stefano F, Frederiksen, Kristian S, Froelich, Lutz, Garibotto, Valentina, Haliassos, Alexander, Jessen, Frank, Kamondi, Anita, Kessels, Roy PC, Morbelli, Silvia D, O'Brien, John T, Otto, Markus, Perret-Liaudet, Armand, Pizzini, Francesca B, Vandenbulcke, Mathieu, Vanninen, Ritva, Verhey, Frans, Vernooij, Meike W, Yousry, Tarek, Boada Rovira, Mercè, Dubois, Bruno, Georges, Jean, Hansson, Oskar, Ritchie, Craig W, Scheltens, Philip, van der Flier, Wiesje M, and Nobili, Flavio

Published
2024
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10. Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes

Author

Reus, Lianne M, Pasaniuc, Bogdan, Posthuma, Danielle, Boltz, Toni, Consortium, International FTD-Genomics, Ferrari, Raffaele, Hernandez, Dena G, Nalls, Michael A, Rohrer, Jonathan D, Ramasamy, Adaikalavan, Kwok, John BJ, Dobson-Stone, Carol, Brooks, William S, Schofield, Peter R, Halliday, Glenda M, Hodges, John R, Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Cruchaga, Carlos, Cairns, Nigel J, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Waldö, Maria Landqvist, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian RA, Hsiung, Ging-Yuek R, Mann, David MA, Grafman, Jordan, Morris, Christopher M, Attems, Johannes, Griffiths, Timothy D, McKeith, Ian G, Thomas, Alan J, Pietrini, Pietro, Huey, Edward D, Wassermann, Eric M, Baborie, Atik, Jaros, Evelyn, Tierney, Michael C, Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Diehl-Schmid, Janine, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Rogaeva, Ekaterina, St. George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James B, Schlachetzki, Johannes CM, Uphill, James, Collinge, John, Mead, Simon, Danek, Adrian, Van Deerlin, Vivianna M, Grossman, Murray, Trojanowski, John Q, van der Zee, Julie, Van Broeckhoven, Christine, Cappa, Stefano F, Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E, Hjermind, Lena E, Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, and Gu, Wei

Subjects
Biological Sciences, Genetics, Frontotemporal Dementia (FTD), Neurodegenerative, Human Genome, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Related Dementias (ADRD), Rare Diseases, Acquired Cognitive Impairment, Brain Disorders, Dementia, Aging, Biotechnology, Neurosciences, 2.1 Biological and endogenous factors, Neurological, Frontotemporal Dementia, Gene Expression, Humans, International FTD-Genomics Consortium, 17q21.31 inversion region, Dorsolateral prefrontal cortex, Expression quantitative trait loci, Frontotemporal dementia, SEC22B, Transcriptome-wide association study, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences, Psychology
Abstract

BackgroundThe etiology of frontotemporal dementia (FTD) is poorly understood. To identify genes with predicted expression levels associated with FTD, we integrated summary statistics with external reference gene expression data using a transcriptome-wide association study approach.MethodsFUSION software was used to leverage FTD summary statistics (all FTD: n = 2154 cases, n = 4308 controls; behavioral variant FTD: n = 1337 cases, n = 2754 controls; semantic dementia: n = 308 cases, n = 616 controls; progressive nonfluent aphasia: n = 269 cases, n = 538 controls; FTD with motor neuron disease: n = 200 cases, n = 400 controls) from the International FTD-Genomics Consortium with 53 expression quantitative loci tissue type panels (n = 12,205; 5 consortia). Significance was assessed using a 5% false discovery rate threshold.ResultsWe identified 73 significant gene-tissue associations for FTD, representing 44 unique genes in 34 tissue types. Most significant findings were derived from dorsolateral prefrontal cortex splicing data (n = 19 genes, 26%). The 17q21.31 inversion locus contained 23 significant associations, representing 6 unique genes. Other top hits included SEC22B (a gene involved in vesicle trafficking), TRGV5, and ZNF302. A single gene finding (RAB38) was observed for behavioral variant FTD. For other clinical subtypes, no significant associations were observed.ConclusionsWe identified novel candidate genes (e.g., SEC22B) and previously reported risk regions (e.g., 17q21.31) for FTD. Most significant associations were observed in dorsolateral prefrontal cortex splicing data despite the modest sample size of this reference panel. This suggests that our findings are specific to FTD and are likely to be biologically relevant highlights of genes at different FTD risk loci that are contributing to the disease pathology.

Published
2021

13. Speech production differences in English and Italian speakers with nonfluent variant PPA.

Author

Canu, Elisa, Agosta, Federica, Battistella, Giovanni, Spinelli, Edoardo G, DeLeon, Jessica, Welch, Ariane E, Mandelli, Maria Luisa, Hubbard, H Isabel, Moro, Andrea, Magnani, Giuseppe, Cappa, Stefano F, Miller, Bruce L, Filippi, Massimo, and Gorno-Tempini, Maria Luisa

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Aphasia, Neurodegenerative, Frontotemporal Dementia (FTD), Rehabilitation, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Behavioral and Social Science, Brain Disorders, Aging, Rare Diseases, Clinical Research, Alzheimer's Disease Related Dementias (ADRD), Acquired Cognitive Impairment, Neurological, Mental health, Aged, Aphasia, Primary Progressive, Atrophy, Cross-Sectional Studies, Female, Humans, Italy, Language Tests, Magnetic Resonance Imaging, Male, Middle Aged, Psycholinguistics, Severity of Illness Index, United States, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveTo understand whether the clinical phenotype of nonfluent/agrammatic primary progressive aphasia (nfvPPA) could present differences depending on the patient's native language.MethodsIn this cross-sectional study, we analyzed connected speech samples in monolingual English (nfvPPA-E) and Italian speakers (nfvPPA-I) who were diagnosed with nfvPPA and matched for age, sex, and Mini-Mental State Examination scores. Patients also received a comprehensive neuropsychological battery. All patients and 2 groups of age-matched healthy controls underwent an MRI scan with 3D T1-weighted sequences. Connected speech measures and the other cognitive features were compared between patient groups. MRI variables, in terms of gray matter volume, were compared between each patient group and the corresponding controls.ResultsCompared to nfvPPA-E, nfvPPA-I had fewer years of education and shorter reported disease duration. The 2 groups showed similar regional atrophy compatible with clinical diagnosis. Patients did not differ in nonlanguage domains, comprising executive scores. Connected speech sample analysis showed that nfvPPA-E had significantly more distortions than nfvPPA-I, while nfvPPA-I showed reduced scores in some measures of syntactic complexity. On language measures, Italian speakers performed more poorly on syntactic comprehension.ConclusionsnfvPPA-E showed greater motor speech impairment than nfvPPA-I despite higher level of education and comparable disease severity and atrophy changes. The data also suggest greater grammatical impairment in nfvPPA-I. This study illustrates the need to take into account the possible effect of the individual's spoken language on the phenotype and clinical presentation of primary progressive aphasia variants.

Published
2020

14. Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood

Author

Ferrari, Raffaele, Hernandez, Dena G., Nalls, Michael A., Rohrer, Jonathan D., Ramasamy, Adaikalavan, Kwok, John B.J., Dobson-Stone, Carol, Brooks, William S., Schofield, Peter R., Halliday, Glenda M., Hodges, John R., Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Haan, Eric, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Cruchaga, Carlos, Cairns, Nigel J., Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Waldö, Maria Landqvist, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian R.A., Hsiung, Ging-Yuek R., Mann, David M.A., Grafman, Jordan, Morris, Christopher M., Attems, Johannes, Griffiths, Timothy D., McKeith, Ian G., Thomas, Alan J., Pietrini, P., Huey, Edward D., Wassermann, Eric M., Baborie, Atik, Jaros, Evelyn, Tierney, Michael C., Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Diehl-Schmid, Janine, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Rogaeva, Ekaterina, St. George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James B., Schlachetzki, Johannes C.M., Uphill, James, Collinge, John, Mead, Simon, Danek, Adrian, Van Deerlin, Vivianna M., Grossman, Murray, Trojanowski, John Q., van der Zee, Julie, Deschamps, William, Van Langenhove, Tim, Cruts, Marc, Van Broeckhoven, Christine, Cappa, Stefano F., Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E., Hjermind, Lena E., Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, Rossor, Martin N., Fox, Nick C., Warren, Jason D., Spillantini, Maria Grazia, Morris, Huw R., Rizzu, Patrizia, Heutink, Peter, Snowden, Julie S., Rollinson, Sara, Richardson, Anna, Gerhard, Alexander, Bruni, Amalia C., Maletta, Raffaele, Frangipane, Francesca, Cupidi, Chiara, Bernardi, Livia, Anfossi, Maria, Gallo, Maura, Conidi, Maria Elena, Smirne, Nicoletta, Rademakers, Rosa, Baker, Matt, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Knopman, David, Josephs, Keith A., Boeve, Bradley F., Parisi, Joseph E., Seeley, William W., Miller, Bruce L., Karydas, Anna M., Rosen, Howard, van Swieten, John C., Dopper, Elise G.P., Seelaar, Harro, Pijnenburg, Yolande A.L., Scheltens, Philip, Logroscino, Giancarlo, Capozzo, Rosa, Novelli, Valeria, Puca, Annibale A., Franceschi, Massimo, Postiglione, Alfredo, Milan, Graziella, Sorrentino, Paolo, Kristiansen, Mark, Chiang, Huei-Hsin, Graff, Caroline, Pasquier, Florence, Rollin, Adeline, Deramecourt, Vincent, Lebert, Florence, Kapogiannis, Dimitrios, Ferrucci, Luigi, Pickering-Brown, Stuart, Singleton, Andrew B., Hardy, John, Momeni, Parastoo, Ge, Yi-Jun, Ou, Ya-Nan, Deng, Yue-Ting, Wu, Bang-Sheng, Yang, Liu, Zhang, Ya-Ru, Chen, Shi-Dong, Huang, Yu-Yuan, Dong, Qiang, Tan, Lan, and Yu, Jin-Tai

Published
2023
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22. Toward noninvasive brain stimulation 2.0 in Alzheimer’s disease

Author

Menardi, Arianna, Rossi, Simone, Koch, Giacomo, Hampel, Harald, Vergallo, Andrea, Nitsche, Michael A., Stern, Yaakov, Borroni, Barbara, Cappa, Stefano F., Cotelli, Maria, Ruffini, Giulio, El-Fakhri, Georges, Rossini, Paolo M., Dickerson, Brad, Antal, Andrea, Babiloni, Claudio, Lefaucheur, Jean-Pascal, Dubois, Bruno, Deco, Gustavo, Ziemann, Ulf, Pascual-Leone, Alvaro, and Santarnecchi, Emiliano

Published
2022
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23. Consensus classification of posterior cortical atrophy

Author

Crutch, Sebastian J, Schott, Jonathan M, Rabinovici, Gil D, Murray, Melissa, Snowden, Julie S, van der Flier, Wiesje M, Dickerson, Bradford C, Vandenberghe, Rik, Ahmed, Samrah, Bak, Thomas H, Boeve, Bradley F, Butler, Christopher, Cappa, Stefano F, Ceccaldi, Mathieu, de Souza, Leonardo Cruz, Dubois, Bruno, Felician, Olivier, Galasko, Douglas, Graff‐Radford, Jonathan, Graff‐Radford, Neill R, Hof, Patrick R, Krolak‐Salmon, Pierre, Lehmann, Manja, Magnin, Eloi, Mendez, Mario F, Nestor, Peter J, Onyike, Chiadi U, Pelak, Victoria S, Pijnenburg, Yolande, Primativo, Silvia, Rossor, Martin N, Ryan, Natalie S, Scheltens, Philip, Shakespeare, Timothy J, González, Aida Suárez, Tang‐Wai, David F, Yong, Keir XX, Carrillo, Maria, Fox, Nick C, and Area, Alzheimer's Association ISTAART Atypical Alzheimer's Disease and Associated Syndromes Professional Interest

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurodegenerative, Rare Diseases, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Aging, Dementia, Acquired Cognitive Impairment, Brain Disorders, Neurological, Brain, Brain Diseases, Humans, Posterior cortical atrophy, Alzheimer's disease, Clinico-radiological syndrome, Pathophysiology, Biomarker, Alzheimer's Association ISTAART Atypical Alzheimer's Disease and Associated Syndromes Professional Interest Area, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionA classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.MethodsConsensus statements about PCA were developed through a detailed literature review, the formation of an international multidisciplinary working party which convened on four occasions, and a Web-based quantitative survey regarding symptom frequency and the conceptualization of PCA.ResultsA three-level classification framework for PCA is described comprising both syndrome- and disease-level descriptions. Classification level 1 (PCA) defines the core clinical, cognitive, and neuroimaging features and exclusion criteria of the clinico-radiological syndrome. Classification level 2 (PCA-pure, PCA-plus) establishes whether, in addition to the core PCA syndrome, the core features of any other neurodegenerative syndromes are present. Classification level 3 (PCA attributable to AD [PCA-AD], Lewy body disease [PCA-LBD], corticobasal degeneration [PCA-CBD], prion disease [PCA-prion]) provides a more formal determination of the underlying cause of the PCA syndrome, based on available pathophysiological biomarker evidence. The issue of additional syndrome-level descriptors is discussed in relation to the challenges of defining stages of syndrome severity and characterizing phenotypic heterogeneity within the PCA spectrum.DiscussionThere was strong agreement regarding the definition of the core clinico-radiological syndrome, meaning that the current consensus statement should be regarded as a refinement, development, and extension of previous single-center PCA criteria rather than any wholesale alteration or redescription of the syndrome. The framework and terminology may facilitate the interpretation of research data across studies, be applicable across a broad range of research scenarios (e.g., behavioral interventions, pharmacological trials), and provide a foundation for future collaborative work.

Published
2017

24. Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes

Author

Ferrari, Raffaele, Hernandez, Dena G., Nalls, Michael A., Rohrer, Jonathan D., Ramasamy, Adaikalavan, Kwok, John B.J., Dobson-Stone, Carol, Brooks, William S., Schofield, Peter R., Halliday, Glenda M., Hodges, John R., Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Cruchaga, Carlos, Cairns, Nigel J., Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Waldö, Maria Landqvist, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian R.A., Hsiung, Ging-Yuek R., Mann, David M.A., Grafman, Jordan, Morris, Christopher M., Attems, Johannes, Griffiths, Timothy D., McKeith, Ian G., Thomas, Alan J., Pietrini, Pietro, Huey, Edward D., Wassermann, Eric M., Baborie, Atik, Jaros, Evelyn, Tierney, Michael C., Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Diehl-Schmid, Janine, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Rogaeva, Ekaterina, St. George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James B., Schlachetzki, Johannes C.M., Uphill, James, Collinge, John, Mead, Simon, Danek, Adrian, Van Deerlin, Vivianna M., Grossman, Murray, Trojanowski, John Q., van der Zee, Julie, Van Broeckhoven, Christine, Cappa, Stefano F., Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E., Hjermind, Lena E., Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, Rossor, Martin N., Fox, Nick C., Warren, Jason D., Spillantini, Maria Grazia, Morris, Huw R., Rizzu, Patrizia, Heutink, Peter, Snowden, Julie S., Rollinson, Sara, Richardson, Anna, Gerhard, Alexander, Bruni, Amalia C., Maletta, Raffaele, Frangipane, Francesca, Cupidi, Chiara, Bernardi, Livia, Anfossi, Maria, Gallo, Maura, Conidi, Maria Elena, Smirne, Nicoletta, Rademakers, Rosa, Baker, Matt, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Knopman, David, Josephs, Keith A., Boeve, Bradley F., Parisi, Joseph E., Seeley, William W., Miller, Bruce L., Karydas, Anna M., Rosen, Howard, van Swieten, John C., Dopper, Elise G.P., Seelaar, Harro, Pijnenburg, Yolande A.L., Scheltens, Philip, Logroscino, Giancarlo, Capozzo, Rosa, Novelli, Valeria, Puca, Annibale A., Franceschi, Massimo, Postiglione, Alfredo, Milan, Graziella, Sorrentino, Paolo, Kristiansen, Mark, Chiang, Huei-Hsin, Graff, Caroline, Pasquier, Florence, Rollin, Adeline, Deramecourt, Vincent, Lebert, Florence, Kapogiannis, Dimitrios, Ferrucci, Luigi, Pickering-Brown, Stuart, Singleton, Andrew B., Hardy, John, Momeni, Parastoo, Reus, Lianne M., Pasaniuc, Bogdan, Posthuma, Danielle, Boltz, Toni, and Ophoff, Roel A.

Published
2021
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27. Cognitive assessment: More important than ever.

Author

Cappa, Stefano F.

Subjects
*DISEASE risk factors, *ALZHEIMER'S disease, *MEDICAL personnel, *COVID-19 pandemic, *GENERAL Data Protection Regulation, 2016
Abstract

This document is a list of references from scientific articles that cover various topics related to cognitive assessment and Alzheimer's disease. The articles discuss the definition and diagnosis of Alzheimer's disease, the progression rates of mild cognitive impairment, the use of biomarkers for diagnosis, and the development of AI systems for early screening. They also explore the importance of cognitive assessment in the context of aging and the impact of the COVID-19 pandemic on teleneuropsychology. These references are valuable resources for library patrons conducting research on cognitive assessment and Alzheimer's disease. [Extracted from the article]

Published
2024
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34. Sharing brain imaging data in the Open Science era:how and why?

Author

Giehl, Kathrin, Mutsaerts, Henk Jan, Aarts, Kristien, Barkhof, Frederik, Caspers, Svenja, Chetelat, Gaël, Colin, Marie Elisabeth, Düzel, Emrah, Frisoni, Giovanni B., Ikram, M. Arfan, Jovicich, Jorge, Morbelli, Silvia, Oertel, Wolfgang, Paret, Christian, Perani, Daniela, Ritter, Petra, Segura, Bàrbara, Wisse, Laura E.M., De Witte, Elke, Cappa, Stefano F., van Eimeren, Thilo, Giehl, Kathrin, Mutsaerts, Henk Jan, Aarts, Kristien, Barkhof, Frederik, Caspers, Svenja, Chetelat, Gaël, Colin, Marie Elisabeth, Düzel, Emrah, Frisoni, Giovanni B., Ikram, M. Arfan, Jovicich, Jorge, Morbelli, Silvia, Oertel, Wolfgang, Paret, Christian, Perani, Daniela, Ritter, Petra, Segura, Bàrbara, Wisse, Laura E.M., De Witte, Elke, Cappa, Stefano F., and van Eimeren, Thilo

Abstract

The sharing of human neuroimaging data has great potential to accelerate the development of imaging biomarkers in neurological and psychiatric disorders; however, major obstacles remain in terms of how and why to share data in the Open Science context. In this Health Policy by the European Cluster for Imaging Biomarkers, we outline the current main opportunities and challenges based on the results of an online survey disseminated among senior scientists in the field. Although the scientific community fully recognises the importance of data sharing, technical, legal, and motivational aspects often prevent active adoption. Therefore, we provide practical advice on how to overcome the technical barriers. We also call for a harmonised application of the General Data Protection Regulation across EU countries. Finally, we suggest the development of a system that makes data count by recognising the generation and sharing of data as a highly valuable contribution to the community.

Published
2024

35. European intersocietal recommendations for the biomarker-based diagnosis of neurocognitive disorders

Author

Frisoni, Giovanni B., Festari, Cristina, Massa, Federico, Cotta Ramusino, Matteo, Orini, Stefania, Aarsland, Dag, Agosta, Federica, Babiloni, Claudio, Borroni, Barbara, Cappa, Stefano F., Frederiksen, Kristian S., Froelich, Lutz, Garibotto, Valentina, Haliassos, Alexander, Jessen, Frank, Kamondi, Anita, Kessels, Roy PC, Morbelli, Silvia D., O'Brien, John T., Otto, Markus, Perret-Liaudet, Armand, Pizzini, Francesca B., Vandenbulcke, Mathieu, Vanninen, Ritva, Verhey, Frans, Vernooij, Meike W., Yousry, Tarek, Boada Rovira, Mercè, Dubois, Bruno, Georges, Jean, Hansson, Oskar, Ritchie, Craig W., Scheltens, Philip, van der Flier, Wiesje M., Nobili, Flavio, Frisoni, Giovanni B., Festari, Cristina, Massa, Federico, Cotta Ramusino, Matteo, Orini, Stefania, Aarsland, Dag, Agosta, Federica, Babiloni, Claudio, Borroni, Barbara, Cappa, Stefano F., Frederiksen, Kristian S., Froelich, Lutz, Garibotto, Valentina, Haliassos, Alexander, Jessen, Frank, Kamondi, Anita, Kessels, Roy PC, Morbelli, Silvia D., O'Brien, John T., Otto, Markus, Perret-Liaudet, Armand, Pizzini, Francesca B., Vandenbulcke, Mathieu, Vanninen, Ritva, Verhey, Frans, Vernooij, Meike W., Yousry, Tarek, Boada Rovira, Mercè, Dubois, Bruno, Georges, Jean, Hansson, Oskar, Ritchie, Craig W., Scheltens, Philip, van der Flier, Wiesje M., and Nobili, Flavio

Abstract

The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease emphasises the need for consensus recommendations on the rational use of biomarkers to diagnose people with suspected neurocognitive disorders in memory clinics. Most available recommendations and guidelines are either disease-centred or biomarker-centred. A European multidisciplinary taskforce consisting of 22 experts from 11 European scientific societies set out to define the first patient-centred diagnostic workflow that aims to prioritise testing for available biomarkers in individuals attending memory clinics. After an extensive literature review, we used a Delphi consensus procedure to identify 11 clinical syndromes, based on clinical history and examination, neuropsychology, blood tests, structural imaging, and, in some cases, EEG. We recommend first-line and, if needed, second-line testing for biomarkers according to the patient's clinical profile and the results of previous biomarker findings. This diagnostic workflow will promote consistency in the diagnosis of neurocognitive disorders across European countries.

Published
2024

38. The language profile of progressive supranuclear palsy

Author

Catricalà, Eleonora, Boschi, Veronica, Cuoco, Sofia, Galiano, Francesco, Picillo, Marina, Gobbi, Elena, Miozzo, Antonio, Chesi, Cristiano, Esposito, Valentina, Santangelo, Gabriella, Pellecchia, Maria Teresa, Borsa, Virginia M., Barone, Paolo, Garrard, Peter, Iannaccone, Sandro, and Cappa, Stefano F.

Published
2019
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39. Frontotemporal dementia and its subtypes: a genome-wide association study

Author

Ferrari, Raffaele, Hernandez, Dena G, Nalls, Michael A, Rohrer, Jonathan D, Ramasamy, Adaikalavan, Kwok, John BJ, Dobson-Stone, Carol, Brooks, William S, Schofield, Peter R, Halliday, Glenda M, Hodges, John R, Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Haan, Eric, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Cruchaga, Carlos, Cairns, Nigel J, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Waldö, Maria Landqvist, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian RA, Hsiung, Ging-Yuek R, Mann, David MA, Grafman, Jordan, Morris, Christopher M, Attems, Johannes, Griffiths, Timothy D, McKeith, Ian G, Thomas, Alan J, Pietrini, P, Huey, Edward D, Wassermann, Eric M, Baborie, Atik, Jaros, Evelyn, Tierney, Michael C, Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Diehl-Schmid, Janine, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Rogaeva, Ekaterina, St George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James B, Schlachetzki, Johannes CM, Uphill, James, Collinge, John, Mead, Simon, Danek, Adrian, Van Deerlin, Vivianna M, Grossman, Murray, Trojanowski, John Q, van der Zee, Julie, Deschamps, William, Van Langenhove, Tim, Cruts, Marc, Van Broeckhoven, Christine, Cappa, Stefano F, Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E, Hjermind, Lena E, Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, and Rossor, Martin N

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Dementia, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Related Dementias (ADRD), Frontotemporal Dementia (FTD), Aging, Human Genome, Brain Disorders, Prevention, Rare Diseases, Acquired Cognitive Impairment, Neurodegenerative, Genetics, 2.1 Biological and endogenous factors, Neurological, Adult, Aged, Aged, 80 and over, Female, Frontotemporal Dementia, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Neurology & Neurosurgery, Clinical sciences
Abstract

BackgroundFrontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes-MAPT, GRN, and C9orf72--have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder.MethodsWe did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with FTD and 9402 healthy controls. To reduce genetic heterogeneity, all participants were of European ancestry. In the discovery phase (samples from 2154 patients with FTD and 4308 controls), we did separate association analyses for each FTD subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and FTD overlapping with motor neuron disease [FTD-MND]), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p

Published
2014

40. Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study.

Author

Manenti, Rosa, Baglio, Francesca, Pagnoni, Ilaria, Gobbi, Elena, Campana, Elena, Alaimo, Cristina, Rossetto, Federica, Di Tella, Sonia, Pagliari, Chiara, Geviti, Andrea, Bonfiglio, Natale Salvatore, Calabrò, Rocco Salvatore, Cimino, Vincenzo, Binetti, Giuliano, Quartarone, Angelo, Bramanti, Placido, Cappa, Stefano F., and Cotelli, Paolo Maria Rossini Maria

Subjects
HOME care services, MILD cognitive impairment, RESEARCH funding, EPISODIC memory, PREFRONTAL cortex, STATISTICAL sampling, QUESTIONNAIRES, EXECUTIVE function, KRUSKAL-Wallis Test, TELEREHABILITATION, TREATMENT effectiveness, RANDOMIZED controlled trials, CHI-squared test, VIRTUAL reality, ATTENTION, COMBINED modality therapy, RESEARCH, GERIATRIC Depression Scale, NEUROPSYCHOLOGICAL tests, ANALYSIS of variance, COGNITIVE therapy, COGNITION
Abstract

Background: In recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI). Objective: The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU). Results: An improvement in episodic memory was observed after the end of clinic-atDCS-VRRS (p < 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU. Moreover, the combined treatment led to prolonged beneficial effects (clinicatDCS- VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: p = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS: p = 0.06). Discussion: The present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Comparing two picture naming tasks in Primary Progressive Aphasia: insights from behavioural and neural results

Author

Conca, Francesca, primary, Polito, Cristina, additional, Santi, Gaia Chiara, additional, Esposito, Valentina, additional, Caminiti, Silvia P, additional, Boccalini, Cecilia, additional, Berti, Valentina, additional, Morinelli, Carmen, additional, Mazzeo, Salvatore, additional, Marcone, Alessandra, additional, Iannaccone, Sandro, additional, Bessi, Valentina, additional, Sorbi, Sandro, additional, Perani, Daniela, additional, Cappa, Stefano F, additional, and Catricalà, Eleonora, additional

Published
2023
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44. Neural signatures of cognitive heterogeneity in primary progressive aphasia: a data‐driven transdiagnostic approach

Author

Ramanan, Siddharth, primary, Halai, Ajay D, additional, Garcia‐Penton, Lorna, additional, Perry, Alistair, additional, Patel, Nikil, additional, Peterson, Katie A, additional, Ingram, Ruth, additional, Storey, Ian, additional, Cappa, Stefano F, additional, Catricala, Eleonora, additional, Patterson, Karalyn, additional, Rowe, James B., additional, Garrard, Peter, additional, and Ralph, Matthew A Lambon, additional

Published
2023
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