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1. Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

2. A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase.

3. A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth.

4. NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis.

5. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.

6. Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells.

7. The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling.

8. The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency ( k cat / K m ) of CK1α.

9. Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study.

10. Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.

11. A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.

12. Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma.

13. Notch Represses Transcription by PRC2 Recruitment to the Ternary Complex.

14. Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.

15. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

16. The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression.

17. p16 loss rescues functional decline of Brca1-deficient mammary stem cells.

18. p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.

19. Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.

20. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.

21. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.

22. Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner.

23. Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion.

24. The Notch signaling pathway in esophageal adenocarcinoma.

25. GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth.

26. Epigenetic pathways and glioblastoma treatment: insights from signaling cascades.

27. Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.

28. BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development.

29. Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma.

30. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

31. Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

32. Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

33. Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses.

34. Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53.

36. The hedgehog processing pathway is required for NSCLC growth and survival.

37. Hedgehog signaling regulates bladder cancer growth and tumorigenicity.

38. Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity.

39. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.

40. Notch signalling in solid tumours: a little bit of everything but not all the time.

41. Assembly of a Notch transcriptional activation complex requires multimerization.

42. Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia.

43. Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

44. Epimorphic regeneration in mice is p53-independent.

45. Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.

46. Active Notch1 confers a transformed phenotype to primary human melanocytes.

47. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.

48. It's T-ALL about Notch.

49. Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.

50. Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

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