400 results on '"Capital Financing economics"'
Search Results
2. Impact of COVID-19 on Characteristics and Funding of U.S. Healthcare Startups: Retrospective Review.
- Author
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Ganeshan S, Goldstein J, Sohn YJ, Pollack A, Phillips RS, and Rotenstein L
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- Delivery of Health Care economics, Pandemics economics, Retrospective Studies, Telemedicine economics, United States, Capital Financing economics, COVID-19 economics
- Abstract
Background: The rise of telehealth and telemedicine during the pandemic allowed patients and providers to develop a sense of comfort with telehealth, which may have increased the demand for virtual-first care solutions with spillover effects into venture capital funding., Objective: We aimed to understand the size and type of digital health investments occurring in the prepandemic and pandemic periods., Methods: We examined health care companies founded from March 14, 2019, to March 14, 2020 (prepandemic) versus those founded from March 15, 2020, to March 14, 2022, after pandemic onset. Data were obtained from Crunchbase, a publicly available database that catalogs information about venture capital investments for companies. We also compared companies founded prepandemic to those founded after the first year of the pandemic (pandemic steady-state). We performed a Wilcoxon rank sum test to compare median funding amounts. We compared the 2 groups of companies according to the type of funding round raised, geography, health care subcategory, total amount of funding per year since founding, and number of founders., Results: There were 2714 and 2218 companies founded prepandemic and during the pandemic, respectively. The companies were similarly distributed across geographies in the prepandemic and pandemic periods (P=.46) with no significant differences in the number of founders (P=.32). There was a significant difference in total funding per year since founding between prepandemic and pandemic companies (US $10.8 million vs US $20.9 million; P<.001). The distribution of funding rounds differed significantly for companies founded in prepandemic and pandemic periods (P<.001). On excluding data from the first year of the pandemic, there were 581 companies founded in the pandemic steady-state period from March 14, 2021, to March 14, 2022. Companies founded prepandemic had a significantly greater mean number of founders than those founded during the pandemic (P=.02). There was no significant difference in total funding per year since founding between prepandemic and steady-state pandemic companies (US $10.8 million vs US $14.4 million; P=.34). The most common types of health care companies included wellness, biotech/biopharma, and software companies. Distributions of companies across health care subcategories were not significantly different before and during the pandemic. However, significant differences were identified when data from the first year of the pandemic were excluded (P<.001). Companies founded during the steady-state pandemic period were significantly more likely to be classified as artificial intelligence (7.3% vs 4.7%; P=.005), software (17.3% vs 12.7%; P=.002), and insurance (3.3% vs 1.7%; P=.003), and were significantly less likely to be classified as health care diagnostics (2.4% vs 5.1%; P=.002)., Conclusions: We demonstrate no significant changes in the types of health care companies founded before versus during the pandemic, although significant differences emerge when comparing prepandemic companies to those founded after the first year of the pandemic., (©Smitha Ganeshan, Joshua Goldstein, Young-Jin Sohn, Amie Pollack, Russell S Phillips, Lisa Rotenstein. Originally published in JMIR Formative Research (https://formative.jmir.org), 27.08.2024.)
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- 2024
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3. Impact of dual control system of energy consumption and intensity on cost of debt financing: micro-evidence from Chinese listed companies.
- Author
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Tang S, Qi S, and Zhou C
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- China, Fees and Charges, Carbon, Commerce economics, Sustainable Development economics, Capital Financing economics
- Abstract
Capital providers have placed increasing importance on risks associated with transitioning to a low-carbon economy. This study investigates the causal link between energy regulation and cost of debt financing by exploiting regional variations in stringency of the dual control system of total energy consumption and energy intensity (dual controls) to construct a continuous difference-in-difference model. We use a sample of A-share listed firms in 2010-2020 and find that tighter energy regulation leads to higher cost of debt financing. We find that the underlying mechanism is risk premium brought by compliance cost and uncertainties. Further analysis indicates that the impact of dual controls is mainly driven by non-state-owned firms. Lastly, capital providers did not differentiate the interest rates they charge companies based on their level of green transition., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2023
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4. Key determinants of deposits volume using CAMEL rating system: The case of Saudi banks.
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Al-Najjar D and Assous HF
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- Capital Financing economics, Humans, Saudi Arabia, Capital Financing standards, Financial Management, Investments economics
- Abstract
CAMEL is considered one of the well-known banking rating systems used to build a proper bank ranking. In our paper, we investigate the CAMEL rating for Saudi banks, which is considered the second largest banking sector in GCC. The Saudi banking sector consists of 11 banks and is the leading sector in the Saudi stock index (TASI). In this research, we aim to determine the ranking of Saudi banks according to CAMEL composite and CAMEL overall ratings and explore the effects of these ratings on banks' total deposits for the period from 2014 to 2018. The methodology involves four phases. In the first phase, we calculate the key financial ratios of CAMEL's composites for each bank. In the second phase, we rank the banks from 1 to 11 to each one of CAMEL's composites for each bank per year. In the third phase, we rank Saudi banks according to CAMEL composite and CAMEL overall. Finally, in the fourth phase, we run a regression model using CAMEL financial ratios rank as independent variable and banks' total deposits as a dependent variable. Using the stepwise regression method, the results indicated that the best regression model has an adjusted R2 of 73.4% and a standard error of around 0.58. The results further indicated that capital measured by CAR, management as an efficiency ratio, earning with ROE proxy, and liquidity as loans to deposits have positive effects on banks' total deposits. Meanwhile, earnings as net interest income to net revenue and liquidity calculated by CASA have a negative effect on banks' total deposits. Finally, asset quality ratios and the rest of the ratios have no significant effect on banks' total deposits., Competing Interests: The authors have declared that no competing interests exist.
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- 2021
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5. Discovery and Development of Pregabalin (Lyrica): The Role of Public Funding.
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Barenie R, Darrow J, Avorn J, and Kesselheim AS
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- Humans, Capital Financing economics, Drug Development economics, Pregabalin economics, Public Sector economics
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Background and Objectives: Pregabalin (Lyrica), a widely used drug that has generated billions in revenue as a treatment for diabetic neuropathy and other conditions, was originally discovered in an academic medical center, largely supported by public funding. We aimed to define the extent of direct federal public funding that contributed to various stages of pregabalin's development prior to US Food and Drug Administration (FDA) approval., Methods: We identified key research, scientists, and organizations involved in the development of pregabalin from its discovery through FDA approval. Using key terms (e.g., its indications and mechanism of action), we searched PubMed for relevant publications and determined whether each publication was based on federal public funding using the NIH RePORTER. For each award prior to the drug's FDA approval, we scored its potential relatedness to pregabalin's development based on its title, investigator, and organization, and then examined descriptions of the most relevant awards to aid in defining these relationships. The budgets for all related awards were converted to 2020 dollars., Results: Pregabalin was discovered largely on the basis of publicly funded research at Northwestern University; in 1990, it was licensed to Parke-Davis, which further developed it through its FDA approval in 2004. Most key terms were related to the drug and drug target (n = 5) and organizations involved (n = 5), followed by patent-listed inventors (n = 3). These key terms linked 6,438 core project awards and we identified 37 NIH awards related to pregabalin's development: 9 awards through 1990 ($3.3 million) and 28 from 1991 through 2004 ($10.5 million)., Conclusion: Like that of many other widely sold medications, the development of pregabalin relied on public sector as well as industry contributions to its discovery, with relevant NIH awards totaling $13.8 million during its preapproval development., (© 2021 American Academy of Neurology.)
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- 2021
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6. Venture capital, control rights, and family enterprise growth.
- Author
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Pang X and Liu L
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- China, Family Characteristics, Humans, Capital Financing economics, Private Sector economics
- Abstract
This research explores and explains the path of family enterprise venture capital equity financing from the perspective of endogenous family control rights. We adopted unbalanced panel data on Chinese listed companies from 2007 to 2018. Empirical research shows that there are significant differences in the impact of venture capital on the growth performance of family enterprises and non-family enterprises. Venture capital negatively affects the growth performance of family enterprises, while the negative impact of venture capital on family enterprises is not significant. In addition, family control positively moderates the negative impact of venture capital on family enterprise growth performance., Competing Interests: No authors have competing interests
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- 2021
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7. Funding for cancer research by an Indian funding agency, DBT.
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Shenoy SR and Dey B
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- Humans, India epidemiology, Research economics, Biomedical Research economics, Capital Financing economics, Government Agencies economics, Neoplasms economics
- Abstract
Cancer is a group of diseases with major societal impact and accounts for approximately 55 percent of mortality in India. The Indian population is increasing in size and gradually ageing. As a result, the number of people diagnosed with and dying of cancer are increasing. Government funding agencies such as the Department of Biotechnology (DBT) has a clear definitive role in the management and control of cancer. Through Research and Development programs and multi-institutional networking programs, DBT has provided resources to individual investigators and to institutions, to carry out basic, applied, translational and clinical research and to develop new methods to prevent and treat disease and to conduct research especially in challenging areas pertaining to different types of cancer. This article summarizes the funding provided by DBT for different cancer research programs.
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- 2021
8. Financing innovation and enterprises' efficiency of technological innovation in the internet industry: Evidence from China.
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Piao Z and Lin Y
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- China, Commerce economics, Humans, Industry economics, Investments economics, Capital Financing economics, Internet economics, Inventions economics
- Abstract
This study empirically examined the impact of financing innovation on technological innovation efficiency of select internet companies, that were affiliated with China between 2008 and 2017. Analysis was based on their patent and annual report data and used multiple input-output SFA model, system GMM, and panel fixed-effect model. The results are as follows. (1) There is significant variation in overall technological innovation efficiency of listed companies in the internet industry, and there is a downward trend. The technological innovation efficiency of business that use financing innovation methods is higher than those that do not. (2) The number of patents and intangible capital investment of internet businesses increase obviously every year, but there is no corresponding increase in the efficiency of technological innovation, and little intangible capital investment of non-financing innovation businesses. Thus, determining how to effectively improve the overall quality of patents and the efficiency of intangible capital investment is essential to improve the efficiency of technological innovation for Chinese internet businesses. (3) There is a term mismatch in the investment and financing of internet businesses in China. The financing structure between the financing innovation and non-financing innovation businesses has different impacts on the efficiency of technological innovation. And nowadays, more financing channels are short-term debt financing channels which invest in projects to improve the efficiency of technological innovation due to the pressure of debt repayment and the need to protect shareholders' interests. (4) In the panel regression, the coefficients of Icd and Roa are significantly negative, suggesting that the investment efficiency of internet businesses needs to be improved., Competing Interests: The authors have declared that no competing interests exist.
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- 2020
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9. Partnerships between universities and nonprofit transition coaching organizations to increase student success.
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Farruggia SP, Solomon B, Back L, and Coupet J
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- Academic Success, Capital Financing economics, Female, Humans, Interviews as Topic, Male, Mentoring statistics & numerical data, Organizations, Nonprofit economics, Public-Private Sector Partnerships, Socioeconomic Factors, Students statistics & numerical data, Thematic Apperception Test statistics & numerical data, Universities organization & administration, Mentoring methods, Motivation physiology, Organizations, Nonprofit statistics & numerical data, Students psychology, Universities statistics & numerical data
- Abstract
Aims: This study aims to understand the motivations and benefits for universities and nonprofit college access and success organizations to develop formal partnerships., Methods: Participants in this study were staff from a major urban research university (n = 22) and four nonprofit organizations (n = 17) that promote college access and success among underrepresented, low-income, and first-generation college students. Participants engaged in an audio-recorded interview that was transcribed and analyzed using thematic analysis., Results: Data suggested that staff from the universities and nonprofit organizations were both holistic in their understanding of college student success. In addition, they were both motivated to form partnerships in an effort to reduce barriers to success, although they, at times, identified different barriers that they wanted the partnership to address. Both university and nonprofit staff saw increased effectiveness of their practice as a result of partnering and university staff gained a better understanding of the greater nonprofit college access and success community., Conclusion: Given the intense support that nonprofit organizations are able to provide with their level of funding, partnerships with universities can increase the success of underrepresented, low-income, and first-generation college students., (© 2020 Wiley Periodicals LLC.)
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- 2020
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10. A scoping review examining funding trends in health care professions education research from Taiwan (2006-2017).
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Monrouxe LV, Liu GR, Yau SY, and Babovič M
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- Delivery of Health Care statistics & numerical data, Education, Medical statistics & numerical data, Forecasting, Humans, Taiwan, Capital Financing economics, Capital Financing statistics & numerical data, Capital Financing trends, Delivery of Health Care economics, Education, Medical economics, Education, Medical trends
- Abstract
Background: Traditionally health care professions education research (HCPER) is poorly funded, despite it being key to success., Purpose: This unique study maps HCPER evolution within a single country during a period when significant national governmental HCPER funding is introduced., Methods: A scoping review method examined Taiwan's HCPER landscape across 12-years. Literature searches across four databases (OVID Medline; Scopus; Web of Science; the Airiti Library), a manual scan of HCPE journals and hand searches. Endnote and ATLAS.ti managed the data. Demographic and content codes were developed. PRISMA guidelines are used., Discussion: One thousand four hundred and ten articles across 310 journals, with a steady rise in funded studies. Science/Social Science Citation Index and English language publications increased. Nursing Students/Nurses and Medical Students/Physicians are the most common populations. Significant associations with funding was found for indexed and English language publications. National funding influenced quality and local funding positively., Conclusion: Caution around local vs. global needs is highlighted and national funding policies for HCPER are advocated., (Copyright © 2020 Elsevier Inc. All rights reserved.)
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- 2020
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11. The biopharmaceutical anomaly.
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Senior M
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- Delivery of Health Care economics, Humans, Biological Products economics, Capital Financing economics, Drug Industry economics, Economics, Hospital
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- 2020
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12. Ensuring adequate capital investment in Canadian health care.
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Teja B, Daniel I, Pink GH, Brown A, and Klein DJ
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- Canada, Capital Financing economics, Humans, Investments, Private Sector statistics & numerical data, Public Sector statistics & numerical data, Capital Financing trends, Delivery of Health Care economics, Hospital Costs trends
- Abstract
Competing Interests: Competing interests: David Klein reports serving as a consultant for Imperial Capital since 2007 and Searchlight Capital since 2019. In these roles, Dr. Klein assists in the identification of health care investments, due diligence and in board roles. Currently he is not involved in any active health care investments for these funds in Canada or the United States. In addition, he has been appointed to the Health Sector Audit Board for the Province of Ontario. No other competing interests were declared.
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- 2020
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13. Securitization of a Drug Development Mega-Fund: The Time-Certain Research-Backed Obligation.
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Ortiz CE, Stone CA, and Zissu A
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- Humans, Models, Economic, Risk Management economics, Time Factors, Capital Financing economics, Drug Development economics, Drug Industry economics, Financing, Organized economics, Investments economics, Research Design, Research Support as Topic economics
- Abstract
Without sufficient capital, the cost of engaging in sustainable clinical development of a drug or drug compound is exceedingly difficult. Fagnan, Fernandez, Lo, and Stein have proposed the securitization of a drug development "mega-fund" as a means of attracting capital from traditional long-term corporate bond investors to the clinical stage of drug development. Our contribution to this line of thinking is the modeling of the cash flows of such a biopharmaceutical mega-fund and their distributions over time to develop an innovative design of securities that control the timing risk of cash flows. This modeling offers a more efficient means of allocating the cash flows that the mega-fund consumes and generates, in an effort to lower the overall yields required to place the research-backed obligations. The new securities control the cash flow timing risk and the lower cost of funding ultimately means more funds are available to clinically test a treatment or cure. We obtain the cash flow profile of this new security, called 'the time-certain research-backed obligation', by isolating cash flows from two different time distribution of cash flow scenarios, so that investors will be assured of the time frame over which they will receive repayment of their investment. We have offered a security design that will lower the cost of funding the drug mega-fund. Success or failure of a drug is uncorrelated with the performance of the stock or bond markets, thus this asset class that is backed by a portfolio of drugs in the clinical stages of development should have little correlation with other asset markets, making them a valuable addition to diversified portfolios.
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- 2020
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14. Short-term competition and long-term convergence between domestic and global rating agencies: Evidence from China.
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Tian W, Zhou X, Tian Y, and Meng W
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- Capital Financing classification, China, Humans, Investments classification, Organizations classification, Policy, Capital Financing economics, Investments economics, Organizations economics
- Abstract
This article adds to the existing literature on global rating agencies (GRAs, i.e., the S&P, Moody's, and Fitch) and domestic rating agencies (DRAs). In our research, we introduce the reputation, rating cost and rating accuracy of rating agencies to improve the Hotelling model. According to the theoretical analysis and empirical tests, the results show that the open policy of the Chinese rating industry contributes to higher rating quality in the domestic bond market. This open policy leads to rating convergence between DRAs and GRAs from in the long term., Competing Interests: The authors have declared that no competing interests exist.
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- 2020
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15. A contingent valuation experiment about future particle accelerators at CERN.
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Florio M and Giffoni F
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- Adult, Female, Government, Humans, Male, Middle Aged, Capital Financing economics, Research economics, Science economics, Taxes economics
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Investment in basic science is mainly supported by government funding, but little is known about citizens' willingness to pay for large-scale projects. A survey to a representative sample of French taxpayers, designed as a contingent valuation experiment about a future particle accelerator for CERN, reveals that citizens' willingness to pay is correlated with education, income, age, and-crucially-previous awareness, attitudes and interest in science. A (slim) majority of the participants would accept paying more in taxes for CERN. The estimated willingness to pay is higher than the current implicit per capita tax burden of French citizens. The experimental setting is novel and replicable for empirically assessing social attitudes towards science for other research infrastructures and countries., Competing Interests: The authors have declared that no competing interests exist.
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- 2020
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16. Association of the Meaningful Use Electronic Health Record Incentive Program With Health Information Technology Venture Capital Funding.
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Lite S, Gordon WJ, and Stern AD
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- American Recovery and Reinvestment Act, Electronic Health Records legislation & jurisprudence, Entrepreneurship economics, Financing, Government legislation & jurisprudence, Humans, United States, Capital Financing economics, Electronic Health Records economics, Health Care Sector economics, Meaningful Use economics, Reimbursement, Incentive economics
- Abstract
Importance: Although the Health Information Technology for Economic and Clinical Health (HITECH) Act has accelerated electronic health record (EHR) adoption since its passage, clinician satisfaction with EHRs remains low, and the association of HITECH with health care information technology (IT) entrepreneurship has remained largely unstudied., Objective: To determine whether the passage of the HITECH Act was associated with an increase in key measures of health care IT entrepreneurship., Design, Setting, and Participants: This economic evaluation of venture capital (VC) activity in the US from 2000 to 2019 examined funding trends in health care IT, EHR-related companies, and all VC investments before and after the passage of HITECH. A difference-in-differences analysis compared investments in health care IT companies with those of companies in 3 categories: general health care (non-IT), IT (non-health care), and all US VC transactions. Data were analyzed from September 2018 to August 2019., Exposures: Venture capital funding received by US companies before and after the HITECH Act., Main Outcomes and Measures: Venture capital investment in health care IT companies and the proportion of those investments going to seed-stage companies, a proxy for very early-stage entrepreneurship and innovation., Results: The data included 70 982 investments, of which 9425 (13.3%) were seed stage, 10 706 (15.1%) were early stage, and 50 851 (71.6%) were growth stage. After passage of the HITECH Act, investment in both health care IT companies and EHR-related companies increased at a rate much faster (13.0% and 11.4%, respectively) than VC as a whole (6.9%). In addition, the proportion of investments going to seed-stage health care IT companies increased compared with both overall VC investments and non-IT health care investments. Health care IT companies saw increased probabilities of transactions being seed-stage of 5.1% (SE, 2.2%; 95% CI, 0.8% to 9.3%; P = .02) compared with the entire sample of VC transactions and 13.6% (SE, 1.9%; 95% CI, 9.9% to 17.2%; P < .001) compared with non-IT health care VC transactions. Health care IT had essentially 0 increased probability of a transaction being seed stage compared with IT companies outside health care (-0.8% probability; SE, 2.4%; 95% CI, -5.4% to 3.9%; P = .75)., Conclusions and Relevance: Although widespread clinician dissatisfaction with EHR systems remains a challenge, the HITECH Act's incentive program may have catalyzed early-stage entrepreneurship in health care IT, suggesting an important role for incentives in promoting innovation.
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- 2020
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17. Analysis of Venture Capital Investment in Therapeutic Otolaryngologic Devices, 2008-2017.
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Rathi VK, Murr AH, Feng AL, Tauscher JL, Naunheim MR, Kozin ED, and Gray ST
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- Cross-Sectional Studies, Humans, Retrospective Studies, Capital Financing economics, Equipment and Supplies economics, Investments economics, Otolaryngology economics, Otolaryngology instrumentation
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- 2019
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18. Maternal, Infant, and Early Childhood Home Visiting: A Call for a Paradigm Shift in States' Approaches to Funding.
- Author
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Condon EM
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- Adult, Female, Humans, Infant, Infant, Newborn, Male, United States, Capital Financing economics, Child Health Services economics, House Calls economics, Maternal Health Services economics, Patient Protection and Affordable Care Act economics
- Abstract
Early home visiting is a vital health promotion strategy that is widely associated with positive outcomes for vulnerable families. To expand access to these services, the Maternal, Infant, and Early Childhood Home Visiting (MIECHV) program was established under the Affordable Care Act, and over $2 billion have been distributed from the Health Resources and Services Administration to states, territories, and tribal entities to support funding for early home visiting programs serving pregnant women and families with young children (birth to 5 years of age). As of October 2018, 20 programs met Department of Health and Human Services criteria for evidence of effectiveness and were approved to receive MIECHV funding. However, the same few eligible programs receive MIECHV funding in almost all states, likely due to previously established infrastructure prior to establishment of the MIECHV program. Fully capitalizing on this federal investment will require all state policymakers and bureaucrats to reevaluate services currently offered and systematically and transparently develop a menu of home visiting services that will best match the specific needs of the vulnerable families in their communities. Federal incentives and strategies may also improve states' abilities to successfully implement a comprehensive and diverse menu of home visiting service options. By offering a menu of home visiting program models with varying levels of service delivery, home visitor education backgrounds, and targeted domains for improvement, state agencies serving children and families have an opportunity to expand their reach of services, improve cost-effectiveness, and promote optimal outcomes for vulnerable families. Nurses and nursing organizations can play a key role in advocating for this approach.
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- 2019
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19. Carbon Information Disclosure, Marketization, and Cost of Equity Financing.
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Li L, Liu Q, Wang J, and Hong X
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- China, Humans, Private Sector statistics & numerical data, Capital Financing economics, Carbon, Disclosure statistics & numerical data, Privatization statistics & numerical data
- Abstract
Using listed enterprises in China's heavy pollution industry from 2009 to 2013, this study tests the relationship between marketization degree, carbon information disclosure, and the cost of equity financing. The results show that, regardless of marketization degree, the overall level of carbon information disclosure of listed enterprises in China's heavy pollution industry is low. The content of carbon information disclosure is mainly non-financial carbon information, and the financial carbon information disclosure is very low. The cost of equity financing is different in areas with different marketization degrees, specifically speaking, the cost of equity financing is lower in regions with a high marketization degree than that of a low marketization degree. Carbon information disclosure, non-financial carbon information disclosure, and financial carbon information disclosure are negatively correlated with the cost of equity financing. The marketization degree has strengthened the negative correlation between carbon information disclosure, non-financial carbon information disclosure, financial carbon information disclosure, and the cost of equity financing, respectively.
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- 2019
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20. Working capital management policy in health care: The effect of leverage.
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Dalci I and Ozyapici H
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- Administrative Personnel, Efficiency, Organizational, Europe, Humans, Models, Statistical, Capital Financing economics, Delivery of Health Care organization & administration, Financial Management, Hospital organization & administration, Health Policy
- Abstract
Hospitals, which are mainly capital intensive, require large amounts of financial resources to render high-quality services. Accordingly, health care managers and policy makers should take into account the level of debt in managing working capital. This study, therefore, aims to explore whether the financial leverage moderates the relationship between the working capital and profitability for the publicly-listed European Hospitals. The data set including 52 hospitals with 468 observations was solicited from the ORBIS. A regression analysis was carried out. The results reveal that increasing the length of the cash conversion cycle for hospitals with high financial leverage decreases profitability. On the contrary, increasing the length of the cash conversion cycle for the ones having low leverage boosts profitability. The findings of this study suggest that since leverage influences the relationship between the cash conversion cycle and profitability, the degree of financial leverage is an important indicator to be considered by health care managers and policy makers in managing working capital. In addition, by clarifying the effect of leverage, this study helps policy makers understand and estimate the possible impact of working capital changes on profitability. This study also helps managers and decision makers not only apply a tight working capital policy but also decide whether to increase or decrease the length of cash conversion cycle to improve hospital profitability., (Copyright © 2018 Elsevier B.V. All rights reserved.)
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- 2018
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21. The Impact of the National Institute for Pharmaceutical Technology and Education on Academic Research.
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Speedie MK
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- Biomedical Research economics, Biomedical Research trends, Capital Financing economics, Capital Financing trends, Faculty education, Humans, Technology, Pharmaceutical economics, Technology, Pharmaceutical trends, Biomedical Research education, Education, Pharmacy economics, Education, Pharmacy trends, Schools, Pharmacy economics, Schools, Pharmacy trends, Technology, Pharmaceutical education
- Abstract
Surveys of institutional representatives of member institutions and faculty members engaged in the National Institute for Pharmaceutical Technology and Education (NIPTE) revealed that NIPTE is having a positive impact on academic research in the area of pharmaceutical technology by aligning research directions with FDA needs, by providing funding that may not be available elsewhere, and by creating a collegial and collaborative relationship among researchers in this area from various institutions. NIPTE is contributing to the viability of pharmaceutics and pharmaceutical engineering research in academic settings. Some responders cite the fluctuations in funding and relative low levels of funding received as a problem in maintaining programs, but most perceived a positive impact.
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- 2018
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22. The inherent risks associated with newly traded biopharmaceutical firms.
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Williams DR and Spaulding TJ
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- Biological Products economics, Humans, Risk Management, United States, Biological Products therapeutic use, Capital Financing economics, Capital Financing legislation & jurisprudence, Commerce economics, Commerce legislation & jurisprudence, Drug Development economics, Drug Development legislation & jurisprudence, Drug Discovery economics, Drug Discovery legislation & jurisprudence, Drug Industry economics, Drug Industry legislation & jurisprudence, Investments economics, Investments legislation & jurisprudence, Ownership economics, Ownership legislation & jurisprudence
- Abstract
Here, we provide a comprehensive study related to the risks of all biopharmaceutical firms going public in the USA between 1996 and 2015. We found 355 firms that met our requirements for being in the sector that focuses on creating drugs for humans. Collectively, these firms spent approximately US$86.9 billion on research and development (R&D) during this time. They also lost approximately US$69.3 billion in combined net income. We also examine the delisting of these firms from a public market, their number of collaborators at the initial public offering (IPO), and estimate the percentage ownership by other biopharmaceutical firms at the IPO., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2018
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23. "Yes, we know!" (Over)confidence in general knowledge among Austrian entrepreneurs.
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Ilieva V, Brudermann T, and Drakulevski L
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- Adult, Aged, Austria, Bias, Female, Humans, Judgment, Knowledge, Male, Middle Aged, Regression Analysis, Surveys and Questionnaires, Capital Financing economics, Cognition, Decision Making, Entrepreneurship
- Abstract
Overconfidence has been reported to be a common bias among entrepreneurs and might be one cause of the high failure rates observed for new ventures. In this study, we investigate the overconfidence bias in a sample of 92 Austrian entrepreneurs, who responded to a general-knowledge questionnaire. Their levels of overconfidence were assessed by their responses to hard, medium and easy knowledge questions, and the relations of individual, organizational and environmental factors to the bias score were analyzed. The results confirmed that entrepreneurs are indeed prone to expressing overprecision, a type of overconfidence, but not when answering questions of all levels of difficulty. Being a single founder instead of a co-founder was identified as a significant predictor of overconfidence. Confidence, on the other hand, was associated with age and prior entrepreneurial experience, while accuracy was determined solely by age. The results of this study only partly agree with those of previous studies conducted in different national and cultural settings.
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- 2018
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24. Activity-based funding in mental health: a disastrous path.
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de Jong G
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- Australia, Humans, Netherlands, Capital Financing economics, Fraud economics, Mental Health Services economics
- Abstract
Objectives: On the basis of the experience of the Netherlands, this critical commentary will argue why activity-based funding (ABF) in mental health care is a disastrous path that Australia should not take., Conclusions: ABF leads to an exponential growth in health care spending as it encourages diagnostic inflation and overproductivity. It also leads to fraud and an increased bureaucracy that goes hand in hand with demoralisation among health workers. And finally, the increasing treatment claims leads to the reintroduction of productivity limitations, waiting lists and ultimately austerity measures in order to halt the untamed growth of spending.
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- 2018
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25. Letter from Bristol.
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Graham C and Rai D
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- Biomedical Research trends, Capital Financing trends, European Union economics, National Health Programs trends, Pharmaceutical Services trends, United Kingdom, Workforce trends, Biomedical Research economics, Capital Financing economics, National Health Programs economics, Pharmaceutical Services economics, Workforce economics
- Abstract
Competing Interests: None
- Published
- 2017
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26. A Social Network Analysis of the Financial Links Backing Health and Fitness Apps.
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Grundy Q, Held F, and Bero L
- Subjects
- Australia, Canada, Drug Industry, Humans, Industry economics, Industry organization & administration, United States, Capital Financing economics, Capital Financing organization & administration, Commerce economics, Commerce organization & administration, Mobile Applications economics, Social Support
- Abstract
Objectives: To identify the major stakeholders in mobile health app development and to describe their financial relationships using social network analysis., Methods: We conducted a structured content analysis of a purposive sample of prominent health and fitness apps available in November 2015 in the United States, Canada, and Australia. We conducted a social network analysis of apps' developers, investors, other funding sources, and content advisors to describe the financial relationships underpinning health app development., Results: Prominent health and fitness apps are largely developed by private companies based in North America, with an average of 4.7 (SD = 5.5) financial relations, including founders, external investors, acquiring companies, and commercial partnerships. Network analysis revealed a core of 41 sampled apps connected to 415 other entities by 466 financial relations. This core largely comprised apps published by major technology, pharmaceutical, and fashion corporations. About one third of apps named advisors, many of whom had commercial affiliations., Conclusions: Public health needs to extend its scrutiny and advocacy beyond the health messages contained within apps to understanding commercial influences on health and, when necessary, challenging them.
- Published
- 2017
- Full Text
- View/download PDF
27. Dr Patrick Baeuerle, MPM Capital, talks with young scientists.
- Subjects
- Biomedical Research economics, Capital Financing economics, History, 20th Century, History, 21st Century, Humans, Research Personnel economics, Research Personnel psychology, Research Support as Topic economics, Biomedical Research history, Capital Financing history, Career Choice, Research Personnel history, Research Support as Topic history
- Published
- 2017
- Full Text
- View/download PDF
28. Patents as collateral for securitization.
- Author
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Deshpande N and Nagendra A
- Subjects
- Humans, Biotechnology economics, Capital Financing economics, Investments economics, Patents as Topic
- Published
- 2017
- Full Text
- View/download PDF
29. Human capital gaps in vaccine development: an issue for global vaccine development and global health.
- Author
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Cawein A, Emini E, Watson M, Dailey J, Donnelly J, Tresnan D, Evans T, Plotkin S, and Gruber W
- Subjects
- Humans, Biomedical Research economics, Capital Financing economics, Global Health economics, Vaccines economics
- Abstract
Despite the success of vaccines in reducing the morbidity and mortality associated with infectious diseases, many infectious diseases, both newly emerging and well known, lack vaccines. The global capability for beginning-to-end vaccine development has become limited, primarily owing to a scarcity of human capital necessary to guide the development of novel vaccines from the laboratory to the marketplace. Here, we identify and discuss the gaps in human capital necessary for robust vaccine development and make recommendations to begin to address these deficiencies., (© 2017 New York Academy of Sciences.)
- Published
- 2017
- Full Text
- View/download PDF
30. Hospitals benefiting from healthy bond market.
- Author
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Barkholz D
- Subjects
- Economic Competition, Humans, United States, Capital Financing economics, Financial Management, Hospital organization & administration, Investments
- Abstract
The bond market continues to be favorable for hospitals looking to finance projects, growth.
- Published
- 2017
31. US stops funding United Nations Population Fund.
- Author
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Dyer O
- Subjects
- United Nations economics, United States, Capital Financing economics, Population Control economics
- Published
- 2017
- Full Text
- View/download PDF
32. Croydon CCG stops funding IVF treatment to save £800 000 a year.
- Author
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Limb M
- Subjects
- England, Humans, State Medicine, Capital Financing economics, Fertilization in Vitro economics
- Published
- 2017
- Full Text
- View/download PDF
33. Bad debt expense benchmarks.
- Subjects
- United States, Benchmarking, Capital Financing economics, Economics, Hospital statistics & numerical data
- Published
- 2017
34. Finance companies with the largest healthcare loan portfolios: Ranked by amount of loans underwritten in 2016.
- Subjects
- United States, Capital Financing economics, Commerce classification, Health Care Sector economics
- Published
- 2017
35. Aftermarket Performance of Health Care and Biopharmaceutical IPOs: Evidence From ASEAN Countries.
- Author
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Komenkul K and Kiranand S
- Subjects
- Asia, Southeastern, Biotechnology, Capital Financing economics, Humans, Investments economics, Private Sector economics, Time Factors, Drug Industry economics, Entrepreneurship, Health Care Sector statistics & numerical data, Investments statistics & numerical data
- Abstract
We examine the evidence from the long-run abnormal returns using data for 76 health care and biopharmaceutical initial public offerings (IPOs) listed in a 29-year period between 1986 and 2014 in the Association of Southeast Asian Nations (ASEAN) countries such as Indonesia, Malaysia, Singapore, Thailand, the Philippines, Vietnam, Myanmar, and Laos. Based on the event-time approach, the 3-year stock returns of the IPOs are investigated using cumulative abnormal return (CAR) and buy-and-hold abnormal return (BHAR). As a robustness check, the calendar-time approach, related to the market model as well as Fama-French and Carhart models, was applied for verifying long-run abnormal returns. We found evidence that the health care IPOs overperform in the long-run, irrespective of the alternative benchmarks and methods. In addition, when we divide our sample into 5 groups by listing countries, our results show that the health care stock prices of the Singaporean firms behaved differently from those of most of the other firms in ASEAN. The Singaporean IPOs are characterized by a worse post-offering performance, whereas the IPOs of Malaysian and Thai health care companies performed better in the long-run.
- Published
- 2017
- Full Text
- View/download PDF
36. Funding innovation: Moving the business forward.
- Author
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Henry GF
- Subjects
- Biomedical Engineering economics, Equipment Design economics, Humans, Capital Financing economics, Organizational Innovation economics, Surgical Equipment economics
- Abstract
Gary F. Henry is the Principal Consultant of G F Henry and Associates, a management consulting firm based in Charlottesville, Virginia. Mr. Henry has more than 30 years of distinguished experience, including CEO, CFO and COO roles in both established and start-up companies. Gary was named an Ernst & Young Virginia Entrepreneur of the Year in 2001., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
37. Private capital investments in health care provision through mergers and acquisitions: from long-term to acute care.
- Author
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Angeli F and Maarse H
- Subjects
- Capital Financing economics, Critical Care economics, Critical Care organization & administration, Delivery of Health Care economics, Europe, Health Facility Merger economics, Humans, Long-Term Care economics, Long-Term Care organization & administration, Capital Financing organization & administration, Delivery of Health Care organization & administration, Health Facility Merger organization & administration, Investments organization & administration
- Abstract
Objectives: This work aims to test whether different segments of healthcare provision differentially attract private capital and thus offer heterogeneous opportunities for private investors' diversification strategies., Methods: Thomson Reuter's SDC Platinum database provided data on 2563 merger and acquisition (M&A) deals targeting healthcare providers in Western Europe between 1990 and 2010. Longitudinal trends of industrial and geographical characteristics of M&As' targets and acquirers are examined., Results: Our analyses highlight: (i) a relative decrease of long-term care facilities as targets of M&As, replaced by an increasing prominence of general hospitals, (ii) a shrinking share of long-term care facilities as targets of financial service organizations' acquisitions, in favor of general hospitals, and (iii) an absolute and relative decrease of long-term care facilities' role as target of cross-border M&As., Conclusions: We explain the decreasing interest of private investors towards long-term care facilities along three lines of reasoning, which take into account the saturation of the long-term care market and the liberalization of acute care provision across Western European countries, regulatory interventions aimed at reducing private ownership to ensure resident outcomes and new cultural developments in favor of small-sized facilities, which strengthen the fragmentation of the sector. These findings advance the literature investigating the effect of private ownership on health outcomes in long-term facilities. Market, policy and cultural forces have emerged over two decades to jointly regulate the presence of privately owned, large-sized long-term care providers, seemingly contributing to safeguard residents' well-being. Copyright © 2016 John Wiley & Sons, Ltd., (Copyright © 2016 John Wiley & Sons, Ltd.)
- Published
- 2016
- Full Text
- View/download PDF
38. National Institutes of Health Funding in Plastic Surgery: A Crisis?
- Author
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Silvestre J, Abbatematteo JM, Serletti JM, and Chang B
- Subjects
- Female, Humans, Male, Middle Aged, Research Personnel economics, United States, Capital Financing economics, Financing, Government trends, National Institutes of Health (U.S.) economics, Surgery, Plastic economics
- Abstract
Background: Decreasing funding rates and increasing competition for National Institutes of Health research grants have prompted diverse interventions in various fields of biomedicine. Currently, the state of National Institutes of Health funding for plastic surgery research is poorly understood. The purpose of this study was to describe the portfolio of National Institutes of Health grants in academic plastic surgery., Methods: Plastic surgery faculty at integrated and independent programs were queried individually in the National Institutes of Health RePORTER database for grants awarded in 2014. Funding totals, mechanisms, and institutes were calculated. Abstracts were categorized by research type and field of interest. Characteristics of National Institutes of Health-funded principal investigators were elucidated., Results: Eight hundred sixty-one academic plastic surgeons at 94 programs were queried, and only 18 investigators (2.1 percent) were funded at 12 programs (12.8 percent). National Institutes of Health-funded investigators were predominately male (72 percent), fellowship-trained (61 percent), and aged 49.3 ± 7.8 years. A total of 20 awards amounted to $6,916,886, with an average award of $345,844 ± $222,909. Costs were primarily awarded through the R01 mechanism (77.2 percent). The top three National Institutes of Health institutes awarded 72.9 percent of the entire portfolio. Funding supported clinical (41.1 percent), translational (36.9 percent), and basic science (22.0 percent) research. Craniofacial (20.5 percent), hand (18.7 percent), and breast (16.2 percent) had the greatest funding., Conclusions: Few programs and faculty drive the National Institutes of Health portfolio of plastic surgery research. These data suggest a tenuous funding situation that may be susceptible to future spending cuts. Future research is needed to identify barriers to National Institutes of Health funding procurement in academic plastic surgery.
- Published
- 2016
- Full Text
- View/download PDF
39. Collaborative funding for NCDs-a model of research funding.
- Author
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Davies J
- Subjects
- Biomedical Research trends, Capital Financing trends, Global Health trends, Humans, Noncommunicable Diseases epidemiology, Noncommunicable Diseases therapy, Biomedical Research economics, Capital Financing economics, Cooperative Behavior, Global Health economics, Noncommunicable Diseases economics
- Published
- 2016
- Full Text
- View/download PDF
40. Resistance is futile. The quest for a new antibiotic.
- Author
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Berki B
- Subjects
- Humans, United Kingdom, Anti-Bacterial Agents therapeutic use, Capital Financing economics, Charities education, Drug Resistance, Drug Resistance, Bacterial drug effects, Sepsis drug therapy
- Published
- 2016
41. Largest healthcare real estate investment trusts Publicly traded healthcare REITs ranked by market capitalization, as of May 31.
- Subjects
- United States, Capital Financing economics, Health Facilities economics, Investments economics
- Published
- 2016
42. Capital Finance: Meeting new equipment needs and reducing capital costs.
- Author
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Jordahl EA, Robbins M, and Sedlmeier M
- Subjects
- Decision Making, Organizational, United States, Capital Expenditures statistics & numerical data, Capital Financing economics, Cost Control, Equipment and Supplies, Hospital economics
- Published
- 2016
43. Geographic Disparity in Funding for School Nutrition Environments: Evidence from Mississippi Schools.
- Author
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Chang Y, Carithers T, Leeke S, and Chin F
- Subjects
- Geography, Health Promotion economics, Healthcare Disparities, Humans, Interviews as Topic, Mississippi, Obesity prevention & control, Regression Analysis, Schools economics, Schools organization & administration, Schools statistics & numerical data, Capital Financing economics, Capital Financing organization & administration, Food Services economics, Food Services organization & administration, Health Promotion methods, Nutrition Policy economics
- Abstract
Background: Despite the federal initiatives on equitable provision of school nutrition programs, geographic disparity in childhood obesity persists. It may be partly because built-in school nutrition environments rely on each school's efficient use of existing operational funds or its ability to obtain expanded financial support. This study explores how funding acquisition by schools is determined by local community characteristics and how it relates to healthy school meal offerings., Methods: Information about food preparation technology and funding in 811 schools in Mississippi was obtained by in-depth phone interviews of district child nutrition directors and school foodservice managers, which was matched to socioeconomic indicators of schools and communities. Probit models were estimated., Results: About 56% of schools in the sample received some funds toward combination oven/steamers in the last few years. Small schools, schools in non-metro counties, and those in low-income minority areas were significantly less likely to be funded. Obtainment of funds was associated with a 45 percentage-point reduction in the probability of serving fried foods., Conclusions: Funds obtained by schools for advanced food preparation technology contributes to creation of healthier nutrition environments for children. However, fund availability is associated with community characteristics, possibly contributing to geographic disparity of child health., (© 2016, American School Health Association.)
- Published
- 2016
- Full Text
- View/download PDF
44. Finance companies with largest healthcare loan portfolios. Ranked by amount of loans underwritten in 2015.
- Subjects
- Capital Financing economics, United States, Capital Financing statistics & numerical data, Commerce classification, Health Care Sector economics
- Published
- 2016
45. Determinants of the cost of capital for privately financed hospital projects in the UK.
- Author
-
Colla P, Hellowell M, Vecchi V, and Gatti S
- Subjects
- Delivery of Health Care economics, Humans, Investments, United Kingdom, Capital Financing economics, Hospitals, Public-Private Sector Partnerships
- Abstract
Many governments make use of private finance contracts to deliver healthcare infrastructure. Previous work has shown that the rate of return to investors in these markets often exceeds the efficient level. Our focus is on the factors that influence that return. We examine the effect of macroeconomic, project- and firm-level variables using a detailed sample of 84 UK private finance initiative (PFI) contracts signed between 1997 and 2010. Of the above variables, macroeconomic conditions and lead sponsor size are related to the investor return. However, our results show a remarkable degree of stability in the return to investors over the 14-year period. We find evidence of a 'prevailing norm' that is robust to project- and firm-level variation. The sustainability of excess returns over a long period is indicative of a concentrated market structure. We argue that policymakers should consider new mechanisms for increasing competition in the equity market, while ensuring that authorities have the specialist resources required to negotiate efficient contract prices., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
46. The primary reasons behind data sharing, its wider benefits and how to cope with the realities of commercial data.
- Author
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Tellam RL, Rushton P, Schuerman P, Pala I, and Anane D
- Subjects
- Capital Financing economics, Capital Financing organization & administration, Databases, Factual, Humans, Privacy, Information Dissemination legislation & jurisprudence, Information Dissemination methods
- Abstract
Data availability expectations have changed over the years in scientific publishing, nowhere more so than in the field of genomics. This field has spearheaded openness and transparency via public and structured deposition of data. BMC Genomics strongly encourages deposition and unrestricted availability of all primary data underlying research studies both as a way of ensuring reproducibility and standardisation, but also as part of overall community-driven expectation on data deposition and sharing. With funders and publishers moving towards more explicit mandates (regarding data availability), we examined the current barriers to unrestricted availability of data and explored different scenarios in which commercial agreements might run contrary to scientific convention and data sharing policies. In this editorial, Ross Tellam (CSIRO, Australia), Paul Rushton (Texas A&M AgriLife Research) and Peter Schuerman (University of California, Merced), give their views on the importance of data sharing and examine the current challenges in research fields like crop and livestock genomics, where often it is necessary to integrate the interests of academic and commercial stakeholders. We discuss the current approaches, highlight the importance of community-driven standards, and propose ways forward.
- Published
- 2015
- Full Text
- View/download PDF
47. Cuts in public health funding will hit areas of greater need hardest.
- Author
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Griffin M
- Subjects
- Capital Financing legislation & jurisprudence, Delivery of Health Care legislation & jurisprudence, Humans, London, Capital Financing economics, Delivery of Health Care economics
- Published
- 2015
- Full Text
- View/download PDF
48. Financing a Simulation Center.
- Author
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Tsuda S, Mohsin A, and Jones D
- Subjects
- Accreditation, Clinical Competence, Education, Medical, Continuing, Humans, Capital Financing economics, Computer Simulation economics, Education, Medical, Graduate economics, General Surgery economics, General Surgery education, Internship and Residency, Manikins
- Abstract
As simulation-based training has become established within medical and health professional disciplines, skills training laboratories have become a standard in surgery training programs. In 2008, the American College of Surgeons and Association of Program Directors in Surgery developed a simulation-based surgical skills curriculum; the Residency Review Committee for Surgery of the Accreditation Council for Graduate Medical Education mandated access to skills laboratories for all surgery programs. Establishing a surgical skills laboratory and adapting the training curriculum requires a significant amount of resources. This article discusses the financial aspects of establishing a training center, from funding opportunities to budgeting considerations., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
49. Biotechs recoil at hedge fund manager's patent attacks.
- Author
-
Senior M
- Subjects
- Humans, Pharmaceutical Preparations economics, Biotechnology economics, Capital Financing economics, Capital Financing methods, Capital Financing organization & administration, Drug Industry economics, Patents as Topic
- Published
- 2015
- Full Text
- View/download PDF
50. Biotech's wellspring--a survey of the health of the private sector in 2014.
- Author
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Huggett B
- Subjects
- Capital Financing economics, Humans, Drug Industry economics, Private Sector economics
- Published
- 2015
- Full Text
- View/download PDF
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