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1. Thermal Response Estimation in Substation Connectors Using Data-Driven Models

Author

GIACOMETTO, F., CAPELLI, F., ROMERAL, L., RIBA, J.-R., and SALA, E.

Subjects
computer simulation, connectors, finite element methods, predictive models, thermal analysis, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Computer engineering. Computer hardware, TK7885-7895
Abstract

Temperature rise simulations are one of the key steps in the design of high-voltage substation connectors. These simulations help minimizing the number of experimental tests, which are power consuming and expensive. The conventional approach to perform these simulations relies on finite element method (FEM). It is highly desirable to reduce the number of required FEM simulations since they are time-consuming. To this end, this paper presents a data-driven modeling approach to drastically shorten the required simulation time. The data-driven approach estimates the thermal response of substation connectors from the data provided by a reduced number of FEM simulations of different operating conditions, thus allowing extrapolating the thermal response to other operating conditions. In the study, a partitioning method is also applied to enhance the performance of the learning stage of a set of data-driven methods, which are then compared and evaluated in terms of simulation time and accuracy to select the optimal configuration of the data-driven model. Finally, the complete methodology is validated against simulation tests.

Published
2016
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6. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, Giani, P, Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., and Giani P.

Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5 years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n = 168, 46%) and 3 (n = 59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2 weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for <4 weeks: 50% (n = 2/4) vs. 99.1% (n = 109/110) for ≥4 weeks, p = 0.003. In patients with liver cirrhosis, lower rates of SVR12 were observed in patients treated <8 weeks: 83.3% (n = 25/30) vs. 94.6% (n = 209/221) for ≥8 weeks, p = 0.038. Despite premature discontinuation of DAA, high SVR12 rates were observed in a real-life setting for treatment lasting at least 4 weeks in patients with liver fibrosis F0–F3 and 8 weeks in those with liver cirrhosis. On this basis, feasibility of reducing DAA treatment duration should be explored in randomized clinical trials.

Published
2021

8. High rates of sustained virological response despite premature discontinuation of directly acting antivirals in HCV-infected patients treated in a real-life setting

Author

Fabbiani M., Lombardi A., Colaneri M., Del Poggio P., Perini P., D'Ambrosio R., Degasperi E., Dibenedetto C., Giorgini A., Pasulo L., Maggiolo F., Castelli F., Brambilla P., Spinelli O., Re T., Lleo A., Rumi M., Uberti-Foppa C., Soria A., Aghemo A., Lampertico P., Baiguera C., Schiavini M., Fagiuoli S., Bruno R., Borghi M., Soffredini R., Perbellini R., Gori A., Ferroni V., Colpani M., Manini M., Cologni G., Lazzaroni S., Vinci M., De Nicola S., Mazzarelli C., Angelini Zucchetti T., Picciotto V., Puoti M., Rossotti R., Landonio S., Magni C. F., Rizzardini G., Colella E., Columpsi P., Gambaro A., Spolti A., Magnani C., Vigano P., Mena M., Villa M., Caramma I., Basilico C., Capelli F., Biagiotti S., Mazzone A., Saladino V., Baldacci M. P., Gatti F., Varalli L., Morini L., Menzaghi B., Farinazzo M., Meli R., Plaz Torres M. C., Fanetti I., Orellana D., Zermiani P., Zuin M., De Bona A., D'Arminio Monforte A., Capretti A., Taddei M. T., Soncini M., Spinetti A., Zaltron S., Pigozzi M. G., Rossini A., Pan A., Dal Zoppo S., Zoncada A., Memoli M., Salpietro S., Hamid H., Messina E., Colombo A. E., Giglio O., Bonfanti P., Molteni C., Terreni N., Spinzi G., Conforti S., Clerici E., Menozzi F., Buscarini E., Centenaro R., Corbellini A., Noventa F., Gritti S., Giani P., Fabbiani, Massimiliano, Lombardi, Andrea, Colaneri, Marta, Del Poggio, Paolo, Perini, Paolo, D'Ambrosio, Roberta, Degasperi, Elisabetta, Dibenedetto, Clara, Giorgini, Alessia, Pasulo, Luisa, Maggiolo, Franco, Castelli, Francesco, Brambilla, Paola, Spinelli, Ombretta, Tiziana, Re, Lleo, Ana, Rumi, Mariagrazia, Uberti-Foppa, Caterina, Soria, Alessandro, Aghemo, Alessio, Lampertico, Pietro, Baiguera, Chiara, Schiavini, Monica, Fagiuoli, Stefano, Bruno, Raffaele, Fabbiani, M, Lombardi, A, Colaneri, M, Del Poggio, P, Perini, P, D'Ambrosio, R, Degasperi, E, Dibenedetto, C, Giorgini, A, Pasulo, L, Maggiolo, F, Castelli, F, Brambilla, P, Spinelli, O, Re, T, Lleo, A, Rumi, M, Uberti-Foppa, C, Soria, A, Aghemo, A, Lampertico, P, Baiguera, C, Schiavini, M, Fagiuoli, S, Bruno, R, Borghi, M, Soffredini, R, Perbellini, R, Gori, A, Ferroni, V, Colpani, M, Manini, M, Cologni, G, Lazzaroni, S, Vinci, M, De Nicola, S, Mazzarelli, C, Angelini Zucchetti, T, Picciotto, V, Puoti, M, Rossotti, R, Landonio, S, Magni, C, Rizzardini, G, Colella, E, Columpsi, P, Gambaro, A, Spolti, A, Magnani, C, Vigano, P, Mena, M, Villa, M, Caramma, I, Basilico, C, Capelli, F, Biagiotti, S, Mazzone, A, Saladino, V, Baldacci, M, Gatti, F, Varalli, L, Morini, L, Menzaghi, B, Farinazzo, M, Meli, R, Plaz Torres, M, Fanetti, I, Orellana, D, Zermiani, P, Zuin, M, De Bona, A, D'Arminio Monforte, A, Capretti, A, Taddei, M, Soncini, M, Spinetti, A, Zaltron, S, Pigozzi, M, Rossini, A, Pan, A, Dal Zoppo, S, Zoncada, A, Memoli, M, Salpietro, S, Hamid, H, Messina, E, Colombo, A, Giglio, O, Bonfanti, P, Molteni, C, Terreni, N, Spinzi, G, Conforti, S, Clerici, E, Menozzi, F, Buscarini, E, Centenaro, R, Corbellini, A, Noventa, F, Gritti, S, and Giani, P

Subjects
Simeprevir, Male, medicine.medical_specialty, Cirrhosis, SVR, Sofosbuvir, Sustained Virologic Response, liver cirrhosis, antiviral treatment, Hepacivirus, Antiviral Agents, law.invention, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Humans, chronic hepatitis C, Prospective cohort study, DAA, Retrospective Studies, Hepatology, liver cirrhosi, business.industry, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, Discontinuation, Regimen, Infectious Diseases, Treatment Outcome, business, medicine.drug
Abstract

In routine clinical practice, hepatitis C virus-infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE-Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5years, and 53 (14.5%) patients were HIV-co-infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n=168, 46%) and 3 (n=59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for

Published
2021

9. EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma

Author

Colombino M., Paliogiannis P., Cossu A., Santeufemia D.A., Pazzola A., Fadda G.M., Pirina P., Fois A., Putzu C., Ginesu G., Porcu A., Astara G., Scartozzi M., Carta A.M., Defraia E., Guerzoni D., Porcu G., Bardino G., Sini C., Capelli F., Sarobba M.G., Sini M.C., Casula M., Palomba G., Manca A., Pisano M., Doneddu V., and Palmieri G.

Subjects
Male, Lung Neoplasms, DNA Mutational Analysis, Disease, medicine.disease_cause, 0302 clinical medicine, Anaplastic Lymphoma Kinase, Prospective Studies, In Situ Hybridization, Fluorescence, Aged, 80 and over, 0303 health sciences, medicine.diagnostic_test, Incidence, Incidence (epidemiology), DNA, Neoplasm, Middle Aged, Proto-Oncogene Proteins c-met, ErbB Receptors, Survival Rate, Italy, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, KRAS, Sardinian patients, Lung cancer, Research Article, Adult, Pulmonary and Respiratory Medicine, cMET, EGFR, Adenocarcinoma of Lung, BRAF, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Targeted therapies, lung adenocarcinoma, Biomarkers, Tumor, medicine, Humans, Aged, 030304 developmental biology, lcsh:RC705-779, genetic alterations, business.industry, Cancer, lcsh:Diseases of the respiratory system, medicine.disease, ALK, Concomitant, Mutation, Cancer research, business, Fluorescence in situ hybridization
Abstract

Background Lung cancer is one of the most incident neoplastic diseases, and a leading cause of death for cancer worldwide. Knowledge of the incidence of druggable genetic alterations, their correlation with clinical and pathological features of the disease, and their interplay in cases of co-occurrence is crucial for selecting the best therapeutic strategies of patients with non-small cell lung cancer. In this real-life study, we describe the molecular epidemiology of genetic alterations in five driver genes and their correlations with the demographic and clinical characteristics of Sardinian patients with lung adenocarcinoma. Methods Data from 1440 consecutive Sardinian patients with a histologically proven diagnosis of lung adenocarcinoma from January 2011 through July 2016 were prospectively investigated. EGFR mutation analysis was performed for all of them, while KRAS and BRAF mutations were searched in 1047 cases; ALK alterations were determined with fluorescence in situ hybridization in 899 cases, and cMET amplifications in 788 cases. Results KRAS mutations were the most common genetic alterations involving 22.1% of the cases and being mutually exclusive with the EGFR mutations, which were found in 12.6% of them. BRAF mutations, ALK rearrangements, and cMET amplifications were detected in 3.2, 5.3, and 2.1% of the cases, respectively. Concomitant mutations were detected only in a few cases. Conclusions Almost all the genetic alterations studied showed a similar incidence in comparison with other Caucasian populations. Concomitant mutations were rare, and they probably have a scarce impact on the clinical management of Sardinians with lung adenocarcinoma. The low incidence of concomitant cMET amplifications at diagnosis suggests that these alterations are acquired in subsequent phases of the disease, often during treatment with TKIs.

Published
2019
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12. PO-0801: Hypofractionated radiotherapy for HNSCC: a retrospective analysis of single Institution

Author

Sanna, F., primary, Cabras, F., additional, Carai, A., additional, Marogna, S., additional, Musu, A.R., additional, Orefici, E., additional, Piredda, G., additional, Pittau, P., additional, Sini, C., additional, Urpis, M., additional, Pelagatti, L., additional, Santona, M.C., additional, Giobbe, M., additional, Bandinu, L., additional, Cau, S., additional, Canu, L., additional, Salis, F., additional, Dei, S., additional, Capelli, F., additional, and Campoccia, S., additional

Published
2020
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13. PO-0826: Hypofractionated radiotherapyfor HNSCC: a retrospective analysis of single Institution

Author

Sanna, F., primary, Cabras, F., additional, Carai, A., additional, Marogna, S., additional, Musu, A., additional, Orefici, E., additional, Piredda, G., additional, Pittau, P., additional, Sini, C., additional, Urpis, M., additional, Pelagatti, L., additional, Santona, M.C., additional, Giobbe, M., additional, Bandinu, L., additional, Cau, S., additional, Canu, L., additional, Salis, F., additional, Dei, S., additional, Capelli, F., additional, and Campoccia, S., additional

Published
2020
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16. Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C

Author

D'Ambrosio, R, Pasulo, L, Puoti, M, Vinci, M, Schiavini, M, Lazzaroni, S, Soria, A, Gatti, F, Menzaghi, B, Aghemo, A, Capelli, F, Rumi, M, Morini, L, Giorgini, A, Pigozzi, M, Rossini, A, Maggiolo, F, Pan, A, Memoli, M, Spinelli, O, Del Poggio, P, Saladino, V, Spinetti, A, De Bona, A, Capretti, A, Uberti-Foppa, C, Bonfanti, P, Terreni, N, Menozzi, F, Colombo, A, Giglio, O, Centenaro, R, Borghi, M, Baiguera, C, Picciotto, V, Landonio, S, Gori, A, Magnani, C, Noventa, F, Paolucci, S, Lampertico, P, Fagiuoli, S, D'Ambrosio, Roberta, Pasulo, Luisa, Puoti, Massimo, Vinci, Maria, Schiavini, Monica, Lazzaroni, Sergio, Soria, Alessandro, Gatti, Federico, Menzaghi, Barbara, Aghemo, Alessio, Capelli, Francesca, Rumi, Maria Grazia, Morini, Lorenzo, Giorgini, Alessia, Pigozzi, Marie Graciella, Rossini, Angelo, Maggiolo, Franco, Pan, Angelo, Memoli, Massimo, Spinelli, Ombretta, Del Poggio, Paolo, Saladino, Valeria, Spinetti, Angiola, De Bona, Anna, Capretti, Andrea, Uberti-Foppa, Caterina, Bonfanti, Paolo, Terreni, Natalia, Menozzi, Fernanda, Colombo, Alberto Eraldo, Giglio, Omar, Centenaro, Riccardo, Borghi, Marta, Baiguera, Chiara, Picciotto, Viviana, Landonio, Simona, Gori, Andrea, Magnani, Carlo, Noventa, Franco, Paolucci, Stefania, Lampertico, Pietro, Fagiuoli, Stefano, D'Ambrosio, R, Pasulo, L, Puoti, M, Vinci, M, Schiavini, M, Lazzaroni, S, Soria, A, Gatti, F, Menzaghi, B, Aghemo, A, Capelli, F, Rumi, M, Morini, L, Giorgini, A, Pigozzi, M, Rossini, A, Maggiolo, F, Pan, A, Memoli, M, Spinelli, O, Del Poggio, P, Saladino, V, Spinetti, A, De Bona, A, Capretti, A, Uberti-Foppa, C, Bonfanti, P, Terreni, N, Menozzi, F, Colombo, A, Giglio, O, Centenaro, R, Borghi, M, Baiguera, C, Picciotto, V, Landonio, S, Gori, A, Magnani, C, Noventa, F, Paolucci, S, Lampertico, P, Fagiuoli, S, D'Ambrosio, Roberta, Pasulo, Luisa, Puoti, Massimo, Vinci, Maria, Schiavini, Monica, Lazzaroni, Sergio, Soria, Alessandro, Gatti, Federico, Menzaghi, Barbara, Aghemo, Alessio, Capelli, Francesca, Rumi, Maria Grazia, Morini, Lorenzo, Giorgini, Alessia, Pigozzi, Marie Graciella, Rossini, Angelo, Maggiolo, Franco, Pan, Angelo, Memoli, Massimo, Spinelli, Ombretta, Del Poggio, Paolo, Saladino, Valeria, Spinetti, Angiola, De Bona, Anna, Capretti, Andrea, Uberti-Foppa, Caterina, Bonfanti, Paolo, Terreni, Natalia, Menozzi, Fernanda, Colombo, Alberto Eraldo, Giglio, Omar, Centenaro, Riccardo, Borghi, Marta, Baiguera, Chiara, Picciotto, Viviana, Landonio, Simona, Gori, Andrea, Magnani, Carlo, Noventa, Franco, Paolucci, Stefania, Lampertico, Pietro, and Fagiuoli, Stefano

Abstract

Background and Aims: The efficacy and safety of glecaprevir/pibrentasvir (G/P) for patients infected with hepatitis C virus (HCV) have only been investigated in clinical trials, with no real-world data currently available. The aim of our study was to investigate the effectiveness and safety of G/P in a real-world setting.Methods: All patients with HCV consecutively starting G/P between October 2017 and January 2018 within the NAVIGATORE-Lombardia Network were analyzed. G/P was administered according to drug label (8, 12 or 16 weeks). Fibrosis was staged either histologically or by liver stiffness measurement. Sustained virological response (SVR) was defined as undetectable HCV-RNA 12 weeks after the end of treatment.Results: A total of 723 patients (50% males) were treated with G/P, 89% for 8 weeks. The median age of our cohort was median liver stiffness measurement of 6.1 kPa; 84% were F0-2 and 16% were interferon-experienced. Median HCV-RNA was 1,102,600 IU/ml, and 49% of patients had HCV genotype 1 (32% 1b), 28% genotype 2, 10% genotype 3 and 13% genotype 4. The median estimated glomerular filtration rate was 90.2 ml/min, platelet count 209x10(3)/mm(3) and albumin 4.3 g/dl. The SVR rates were 94% in intention-to-treat and 99.3% in per protocol analysis (8-week vs. 12 or 16-week: 99.2% vs. 100%). Five patients failed therapy because of post-treatment relapse; a post-treatment NS5A resistance-associated substitution was detected in 1 case. SVR rates were lower in males (p = 0.002) and in HCV genotype-3 (p = 0.046) patients treated for 8 weeks, but independent of treatment duration, fibrosis stage, baseline HCV-RNA, HIV co-infection, chronic kidney disease stage and viral kinetics. Mild adverse events were reported in 8.3% of the patients, and 0.7% of them prematurely withdrew treatment. Three patients died of drug-unrelated causes.Conclusions: In a large real-world cohort of Italian patients, we confirmed the excellent effectiveness and safety of G/P administered f

Published
2019

18. Quale formazione ? Per quali adulti?

Author

Borgato, R, Capelli, F, CASTIGLIONI, MICAELA DONATELLA, Borgato, R, Capelli, F, Castiglioni, MD, and Castiglioni, M

Subjects
EDA, educazione, formazione, cura, narrazione, autoriflessione, metacompetenze, M-PED/01 - PEDAGOGIA GENERALE E SOCIALE
Abstract

Il contributo mette in connessione nella proposta formativa rivolta agli adulti, la dimensione educativa, formativa e di cura, nella direzione di un'eda che recuperi le proprie origini umanistiche.

Published
2014

19. Il web per favorire l'integrazione

Author

GIUSTI, MARIANGELA, Giusti, M, Capelli, F, GIUSTI, MARIANGELA, Capelli F., GIUSTI, MARIANGELA, Giusti, M, Capelli, F, GIUSTI, MARIANGELA, and Capelli F.

Abstract

L'intervista è centrata sulle esperinze positive di alcuni portali e siti web gestiti dalle comunità immigrate

Published
2012

20. Disease progression and overall survival in Sardinian patients with colorectal cancer according to the kras mutational status

Author

Palomba G, Cossu A, Paliogiannis P, Pazzola A, Baldino G, Scartozzi M, Ionta MT, Ortu S, Capelli F, Lanzillo A, Sedda T, Sanna G, Barca M, Virdis L, Colombino M, Casula M, Manca A, Tanda F, Budroni M, and Palmieri G

Subjects
colon cancer, prognosis, digestive system diseases, mutation analysis
Abstract

Background: Mutation in KRAS gene has been extensively demonstrated to act as a predictor of response to EGFR-targeted agents in patients with colorectal cancer. Less is known about the significance of KRAS mutation as a prognostic factor of disease progression and survival, independently of anti-EGFR therapy. The aim of the present study is to evaluate the prognostic role of the KRAS mutational status in a cohort of Sardinian patients with colorectal cancer. Materials and methods: Five hundred and fifty-one consecutive Sardinian patients with histologically proven diagnosis of invasive colorectal carcinoma were included into the study, regardless of age at diagnosis and disease characteristics. Clinical and pathological disease features were confirmed by medical records, pathology reports, and cancer registry data. For mutational analysis, paraffin embedded tissue samples with at least 70% neoplastic cells were processed; genomic DNA was isolated from tissue sections and DNA quality assessed for each specimen. The coding sequences and splice junctions of exons 2, 3, and 4 in KRAS gene were screened for mutations by direct automated sequencing. Results: KRAS mutations were detected in 183/551 (33%) patients; three of them presented the coexistence of two KRAS mutations in the same primary tumor tissue. Among the 186 KRAS mutations identified, two thirds (125; 67%) were located in codon 12, about one fifth (36; 19.4%) in codon 13, and about one tenth (18; 9.7%) in codon 61. The remaining mutations (7; 3.8%) were detected in uncommonly-affected codons of the KRAS gene. No significant correlations between KRAS mutations and sex, age at diagnosis, anatomical location, and disease stage at the time of diagnosis were found. No prognostic values of KRAS mutations were found for either the time to progression as metastatic disease or the overall survival. When patients were stratified by both KRAS mutational status and sex, a significantly better metastasis-free survival was observed for KRAS-mutated male cases. Considering the gene positions of the identified KRAS mutations, no correlation with both the time to progression as metastatic disease and overall survival was observed. Conclusions: Our data suggest that KRAS mutations are correlated to a slower progression of the disease in males with colorectal cancer from Sardinia, irrespectively of the diagnosis age and the mutation position. Such findings were not confirmed considering the overall survival in both sexes.

Published
2015
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23. CH4/Air Mesocombustor at 3 Bar: Numerical Simulation and Experiments

Author

Minotti, Angelo, Cozzi, F., and Capelli, F.

Subjects
CFD, Chemical efficiency, Detailed chemistry, Mesocombustor, Methane-air combustion, Swirling flow, Swirl Flow, Methane-air combustion, Detailed chemistry, Chemical efficiency, CFD, Swirling flow, Mesocombustor, Combustion Efficiency
Published
2013

27. Disease progression and overall survival in sardinian patients with colorectal cancer according to the kras mutational status

Author

Palomba, G., primary, Cossu, A., additional, Paliogiannis, P., additional, Pazzola, A., additional, Baldino, G., additional, Scartozzi, M., additional, Ionta, M.T., additional, Ortu, S., additional, Capelli, F., additional, Lanzillo, A., additional, Sedda, T., additional, Sanna, G., additional, Barca, M., additional, Virdis, L., additional, Colombino, M., additional, Casula, M., additional, Manca, A., additional, Tanda, F., additional, Budroni, M., additional, and Palmieri, G., additional

Published
2015
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28. Mutations in main candidate genes (egfr, kras, braf) among patients with non-small-cell lung cancer from sardinia

Author

Colombino, M., primary, Paliogiannis, P., additional, Defraia, E., additional, Porcu, G., additional, Pazzola, A., additional, Cordero, L., additional, Palomba, G., additional, Sini, M.C., additional, Manca, A., additional, Carta, A., additional, Saba, E.M., additional, Scotto, T., additional, Sarobba, M.G., additional, Capelli, F., additional, Ortu, S., additional, Baldino, G., additional, Sedda, T., additional, Pirina, P., additional, Budroni, M., additional, Cossu, A., additional, and Palmieri, G., additional

Published
2015
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35. Area pedagogica. Fare educazione interculturale in un dialogo interdisciplinare

Author

Giusti, M, Zurloni, V, Mantovani, F, Realdon, O, Iannaccaro, G, Arcodia, G, Salvati, G, Albanese, O, Farina, E, Della Misericorda, M, Rolla, N, Squarcina, E, Balducci, M, Salvioni, S, Tognetti Bordogna, M, Abdulaziz Al-Nasser, N, Chakraborty, U, McAndrews, B, Capelli, F, Van Aken, M, Bramani, S, Brambilla, G, Zanasi, C, Cucuzza, G, Giusti Mariangela, GIUSTI, MARIANGELA, Giusti, M, Zurloni, V, Mantovani, F, Realdon, O, Iannaccaro, G, Arcodia, G, Salvati, G, Albanese, O, Farina, E, Della Misericorda, M, Rolla, N, Squarcina, E, Balducci, M, Salvioni, S, Tognetti Bordogna, M, Abdulaziz Al-Nasser, N, Chakraborty, U, McAndrews, B, Capelli, F, Van Aken, M, Bramani, S, Brambilla, G, Zanasi, C, Cucuzza, G, Giusti Mariangela, and GIUSTI, MARIANGELA

Abstract

Il saggio tratta dell'educazione interculturale come educazione inclusiva, sostenendo la validità della prospettiva della ricerca e della sperimentazione didattica come metodo nella cultura degli insegnanti e scolastica. Si sostiene la tesi che lo sguardo interculturale degli insegnanti e degli educatori deve cercare occasioni educative di inclusione a scuola e anche al di fuori delle scuole.

Published
2014

36. Diversità culturali e altre idee di natura. Un breve percorso antropologico

Author

Giusti, M, Natoli, S, Zurloni, V, Mantovani, F, Realdon, O, Iannaccaro, G, Arcodia, GF, Salvati, G, Albanese, O, Farina, E, Della Misericordia, M, Rolla, N, Squarcina, E, Balducci, M, Salvioni, SM, Bordogna, MT, Abdulaziz Al-Nasser, N, Chakraborty, U, McAndrews, B, Capelli, F, Bramani, S, Brambilla, G, Zanasi, C, Cucuzza, G, VAN AKEN, M, VAN AKEN, MAURO IVO, Giusti, M, Natoli, S, Zurloni, V, Mantovani, F, Realdon, O, Iannaccaro, G, Arcodia, GF, Salvati, G, Albanese, O, Farina, E, Della Misericordia, M, Rolla, N, Squarcina, E, Balducci, M, Salvioni, SM, Bordogna, MT, Abdulaziz Al-Nasser, N, Chakraborty, U, McAndrews, B, Capelli, F, Bramani, S, Brambilla, G, Zanasi, C, Cucuzza, G, VAN AKEN, M, and VAN AKEN, MAURO IVO

Abstract

Come antropologo che lavora in contesti rurali e di modernizzazione nei “sud” del mondo (Giordania, Egitto ma anche a “casa nostra”), in aree considerate marginali e periferiche, la relazione tra cultura e ambiente è un focus cruciale: per la competizione nella gestione delle risorse (in primis l’acqua), per le dinamiche di globalizzazione che si giocano sempre più intensamente, e soprattutto per l’incontro/scontro culturale attorno a diverse idee, e pratiche, di ciò che noi chiamiamo “natura”. Altri saperi ambientali, altre agri/culture, altre tecniche che partono da “modelli di natura” che raccontano dell’incredibile creatività culturale dei popoli, ma evidenziano una problematica centrale: solo la nostra storia di pensiero ha costruito una campo della “cultura” distinto, e opposto a quello di una “natura”, resa oggetto disponibile alla conoscenza e allo sfruttamento senza limiti. Da un punto di vista antropologico ogni cultura è già multiculturale, perché costituisce sempre una dinamica di selezione e relazione tra gruppi sociali, sistemi simbolici e visioni del mondo, ed è quindi sempre già un confronto con la diversità culturale. I pericoli contemporanei che affronta l’antropologia nella comunicazione culturale sono le esagerazioni, le strumentalizzazioni e le reificazioni della nozione di cultura, oggi spesso parola pass-partout, in visioni culturaliste, dove la cultura è pensata come un contenitore chiuso e fuori dalle relazioni politiche. In molti contesti di intervento dello sviluppo rurale, i saperi locali, le pratiche ecologiche, il senso del luogo, le idee di acqua e di ambiente sono spesso il primo target ad essere censurato, reso invisibili o non colto come attore del cambiamento. Questo proprio perché abbiamo reso universale, transculturale, neutro un modello particolare e storico di natura: un campo esterno alla cultura, certo, immutabile, coerente e ciclico, fuori dalla storia e dalla società, a disposizione dell’azione umana, oggetto e

Published
2014

37. Contributo di Maria Grazia Riva

Author

Borgato, R, Capelli, F, Castiglioni, M, Riva, M, RIVA, MARIA GRAZIA, Borgato, R, Capelli, F, Castiglioni, M, Riva, M, and RIVA, MARIA GRAZIA

Published
2014

38. Per una formazione umanistica

Author

Borgato, R, Capelli, F, CASTIGLIONI, MICAELA DONATELLA, Castiglioni, M, Borgato, R, Capelli, F, CASTIGLIONI, MICAELA DONATELLA, and Castiglioni, M

Abstract

Alcuni studiosi ed esperti di formazione adulta hanno riflettuto sulle caratteristiche dell'offerta formativa diretta agli adulti, partendo dalla constatazione della situazione che la connota, oggi, di disomogeneità e di deriva. Gli stessi autori hanno steso un Manifesto, inserito nel libro, che vuole interrogare l'eda e proporre un suo ritorno alle antiche origini umanistiche

Published
2014

39. Facebook come benessere?

Author

Borgato, R, Capelli, F, Ferraresi, M, Bisio, C, Riva, P, RIVA, PAOLA, Borgato, R, Capelli, F, Ferraresi, M, Bisio, C, Riva, P, and RIVA, PAOLA

Published
2009

48. Epidemiology of hepatitis D virus (HDV) infection in an urban area of Northern Italy.

Author

Paschale, M., Manco, M., Belvisi, L., Magnani, C., Re, T., Viganò, P., Biagiotti, S., Capelli, F., Mazzone, A., Baldacci, M., Ferrara, A., Neri, A., Guastoni, C., Bonazzina, R., Brando, B., and Clerici, P.

Subjects
INTRAVENOUS drug abuse, INFECTIOUS disease transmission, CONFIDENCE intervals, HEPATITIS D, FISHER exact test, IMMIGRANTS, RESEARCH, CROSS-sectional method, HIV seroconversion, SEROPREVALENCE, DESCRIPTIVE statistics
Abstract

Objectives: The introduction of vaccination against hepatitis B initially reduced the number of HBV (hepatitis B virus) and HDV (hepatitis delta virus) infections, but the decreasing trend of HDV infection seems to have stopped. The aim of this study was to assess the prevalence of HDV infection in the general population living in the catchment area of Legnano Hospital in northern Italy. Methods: Of the 22,758 subjects tested in 2007-2008, the 488 who were HBsAg (hepatitis B surface antigen)-positive [including 107 (21.9%) of non-Italian origin] were subsequently tested for anti-HDV antibodies. Results: Of the 488 subjects who tested positive for HBsAg, 24 (4.9%) were anti-HDV positive, all aged between 30 and 60 years. The difference in prevalence between males (7.1%) and females (1.9%) was statistically significant ( p < 0.05), but not that between Italian (5.0%) and non-Italian patients (4.7%). The differences in anti-HDV seropositivity between the patients with acute (0%) and chronic infections (6.3%), and between the incident (2.5%) and prevalent cases (7.4%), were not statistically significant, but there was a significant difference ( p < 0.01) between those with asymptomatic (2.1%) and clinically symptomatic infections (10.3%). Intravenous drug abuse was the main source of infection. Conclusions: In the catchment area of our hospital, the prevalence of HDV infection does not seem to be due to patients of non-Italian origin, but to Italian patients who are not vaccinated against HBV and who survived the HDV epidemic of the 1970s and 1980s. Nevertheless, the increase in the number of immigrants from non-EU countries in recent years is soon likely to lead to a change in the epidemiology of HDV. [ABSTRACT FROM AUTHOR]

Published
2012
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